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https://www.readbyqxmd.com/read/27915067/the-feasibility-and-effects-of-acupuncture-in-an-adolescent-nordic-ski-population
#1
Kristin L Garlanger, William H Fredericks, Alexander Do, Brent A Bauer, Edward R Laskowski
BACKGROUND: Studies investigating the use and effectiveness of acupuncture in adults post exercise have been well documented. Fewer studies involving acupuncture have been completed in the adolescent athlete population. To our knowledge there are no published studies that investigate the use of acupuncture in adolescent athletes within their field of play. OBJECTIVE: To primarily assess the feasibility of performing acupuncture in adolescent Nordic skiers within their athletic environment, and secondarily to measure the effect of acupuncture on muscle soreness and sense of well-being...
November 30, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27575834/pre-exercise-infrared-low-level-laser-therapy-810%C3%A2-nm-in-skeletal-muscle-performance-and-postexercise-recovery-in-humans-what-is-the-optimal-dose-a-randomized-double-blind-placebo-controlled-clinical-trial
#2
Adriane Aver Vanin, Thiago De Marchi, Shaiane Silva Tomazoni, Olga Tairova, Heliodora Leão Casalechi, Paulo de Tarso Camillo de Carvalho, Jan Magnus Bjordal, Ernesto Cesar Leal-Junior
AIM: This study aimed to evaluate the medium-term effects of low-level laser therapy (LLLT or photobiomodulation) in postexercise skeletal muscle recovery and performance enhancement and to identify the optimal dose of 810 nm LLLT. MATERIALS AND METHODS: A randomized, double-blind, placebo-controlled trial was performed, with voluntary participation of 28 high-level soccer athletes. We analyzed maximum voluntary contraction (MVC), delayed onset muscle soreness (DOMS), creatine kinase (CK) activity, and interleukin-6 (IL-6) expression...
October 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27378085/a-clinical-tool-for-predicting-survival-in-als
#3
Jonathan A Knibb, Noa Keren, Anna Kulka, P Nigel Leigh, Sarah Martin, Christopher E Shaw, Miho Tsuda, Ammar Al-Chalabi
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive and usually fatal neurodegenerative disease. Survival from diagnosis varies considerably. Several prognostic factors are known, including site of onset (bulbar or limb), age at symptom onset, delay from onset to diagnosis and the use of riluzole and non-invasive ventilation (NIV). Clinicians and patients would benefit from a practical way of using these factors to provide an individualised prognosis. METHODS: 575 consecutive patients with incident ALS from a population-based registry in South-East England register for ALS (SEALS) were studied...
July 4, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/26962285/myofacial-trigger-points-in-advanced-cancer-patients
#4
Hideaki Hasuo, Tatsuhiko Ishihara, Kenji Kanbara, Mikihiko Fukunaga
Myofascial pain syndrome is started to be recognized as one of important factors of pain in cancer patients. However, no reports on features of myofascial trigger points were found in terminally-ill cancer populations. This time, we encountered 5 patients with myofascial pain syndrome and terminal cancer in whom delirium developed due to increased doses of opioid without a diagnosis of myofascial pain syndrome on initial presentation. The delirium subsided with dose reductions of opioid and treatment of myofascial pain syndrome...
January 2016: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/26809617/diagnosis-of-late-onset-pompe-disease-and-other-muscle-disorders-by-next-generation-sequencing
#5
Sébastien Lévesque, Christiane Auray-Blais, Elaine Gravel, Michel Boutin, Laura Dempsey-Nunez, Pierre-Etienne Jacques, Sébastien Chenier, Sandrine Larue, Marie-France Rioux, Walla Al-Hertani, Amelie Nadeau, Jean Mathieu, Bruno Maranda, Valérie Désilets, Paula J Waters, Joan Keutzer, Stephanie Austin, Priya Kishnani
BACKGROUND: Late-onset Pompe disease (LOPD) is a rare treatable lysosomal storage disorder characterized by progressive lysosomal glycogen accumulation and muscle weakness, with often a limb-girdle pattern. Despite published guidelines, testing for LOPD is often overlooked or delayed in adults, owing to its low frequency compared to other muscle disorders with similar muscle patterns. Next-generation sequencing has the capability to test concurrently for several muscle disorders. This could potentially lead to increased diagnosis of LOPD, disorders with non-specific muscle weakness or atypical patients...
2016: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/26751958/curiouser-and-curiouser-the-macrocyclic-lactone-abamectin-is-also-a-potent-inhibitor-of-pyrantel-tribendimidine-nicotinic-acetylcholine-receptors-of-gastro-intestinal-worms
#6
Melanie Abongwa, Samuel K Buxton, Alan P Robertson, Richard J Martin
Nematode parasites may be controlled with drugs, but their regular application has given rise to concerns about the development of resistance. Drug combinations may be more effective than single drugs and delay the onset of resistance. A combination of the nicotinic antagonist, derquantel, and the macrocyclic lactone, abamectin, has been found to have synergistic anthelmintic effects against gastro-intestinal nematode parasites. We have observed in previous contraction and electrophysiological experiments that derquantel is a potent selective antagonist of nematode parasite muscle nicotinic receptors; and that abamectin is an inhibitor of the same nicotinic receptors...
2016: PloS One
https://www.readbyqxmd.com/read/26669660/high-incidence-and-variable-clinical-outcome-of-cardiac-hypertrophy-due-to-acad9-mutations-in-childhood
#7
Marie Collet, Zahra Assouline, Damien Bonnet, Marlène Rio, Franck Iserin, Daniel Sidi, Alice Goldenberg, Caroline Lardennois, Metodi Dimitrov Metodiev, Birgit Haberberger, Tobias Haack, Arnold Munnich, Holger Prokisch, Agnès Rötig
Acyl-CoA dehydrogenase family, member 9 (ACAD9) mutation is a frequent, usually fatal cause of early-onset cardiac hypertrophy and mitochondrial respiratory chain complex I deficiency in early childhood. We retrospectively studied a series of 20 unrelated children with cardiac hypertrophy and isolated complex I deficiency and identified compound heterozygosity for missense, splice site or frame shift ACAD9 variants in 8/20 patients (40%). Age at onset ranged from neonatal period to 9 years and 5/8 died in infancy...
August 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/26563788/organophosphorus-and-carbamate-insecticide-poisoning
#8
REVIEW
Allister Vale, Marcello Lotti
Both organophosphorus (OP) and carbamate insecticides inhibit acetylcholinesterase (AChE), which results in accumulation of acetylcholine (ACh) at autonomic and some central synapses and at autonomic postganglionic and neuromuscular junctions. As a consequence, ACh binds to, and stimulates, muscarinic and nicotinic receptors, thereby producing characteristic features. With OP insecticides (but not carbamates), "aging" may also occur by partial dealkylation of the serine group at the active site of AChE; recovery of AChE activity requires synthesis of new enzyme in the liver...
2015: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/26523661/assessment-of-muscle-pain-induced-by-elbow-flexor-eccentric-exercise
#9
Wing Yin Lau, Anthony J Blazevich, Michael J Newton, Sam Shi Xuan Wu, Kazunori Nosaka
CONTEXT: Delayed-onset muscle soreness (DOMS) is a common muscle pain that many people experience and is often used as a model of acute muscle pain. Researchers have reported the effects of various interventions on DOMS, but different DOMS assessment protocols used in these studies make it difficult to compare the effects. OBJECTIVE: To investigate DOMS characteristics after elbow-flexor eccentric exercise to establish a standardized DOMS assessment protocol. DESIGN: Descriptive laboratory study...
November 2015: Journal of Athletic Training
https://www.readbyqxmd.com/read/26259285/-biopersistence-and-systemic-distribution-of-intramuscularly-injected-particles-what-impact-on-long-term-tolerability-of-alum-adjuvants
#10
Romain K Gherardi, Josette Cadusseau, François-jérôme Authier
Aluminium oxyhydroxide (alum), a nanocrystalline compound that forms agglomerates, has been widely used as a vaccine adjuvant since 1927, but the mechanisms by which it stimulates immune responses remain poorly understood. Although generally well tolerated, alum may occasionally cause chronic health problems in presumably susceptible individuals. Some individuals may rarely develop delayed-onset diffuse myalgia, chronic exhaustion and cognitive dysfunction, associated with long-term persistence (up to 12 years) of alum-loaded macrophages at site of i...
January 2014: Bulletin de L'Académie Nationale de Médecine
https://www.readbyqxmd.com/read/26209849/timing-of-cortico-muscle-transmission-during-active-movement
#11
Gustaf M Van Acker, Carl W Luchies, Paul D Cheney
Numerous studies have reported large disparities between short cortico-muscle conduction latencies and long recorded delays between cortical firing and evoked muscle activity. Using methods such as spike- and stimulus-triggered averaging of electromyographic (EMG) activity, previous studies have shown that the time delay between corticomotoneuronal (CM) cell firing and onset of facilitation of forelimb muscle activity ranges from 6.7 to 9.8 ms, depending on the muscle group tested. In contrast, numerous studies have reported delays of 60-122 ms between cortical cell firing onset and either EMG or movement onset during motor tasks...
August 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/26058992/the-effect-of-combined-skin-and-deep-tissue-inflammatory-pain-models
#12
Silvia Lo Vecchio, Lars J Petersen, Sara Finocchietti, Parisa Gazerani, Lars Arendt-Nielsen, Thomas Graven-Nielsen
OBJECTIVE: Cutaneous hyperalgesia is prominent in the ultraviolet-B (UVB) model of inflammatory pain. This study investigated possible interactions between cutaneous and deep tissues hyperalgesia. METHODS: A total of 16 healthy volunteers participated in the study. Skin inflammation was induced unilaterally by UVB irradiation (three times of the individual minimal erythema dose) in square-shaped areas on the upper-trapezius and lower-back. Moderate delayed onset muscle soreness (DOMS) was induced bilaterally in the low-back by eccentric exercise...
November 2015: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/26010654/optogenetic-excitation-of-preb%C3%A3-tzinger-complex-neurons-potently-drives-inspiratory-activity-in-vivo
#13
Zaki Alsahafi, Clayton T Dickson, Silvia Pagliardini
KEY POINTS: This study investigates the effects on ventilation of an excitatory stimulus delivered in a spatially and temporally precise manner to the inspiratory oscillator, the preBötzinger complex (preBötC). We used an adeno-associated virus expressing channelrhodopsin driven by the synapsin promoter to target the region of the preBötC. Unilateral optogenetic stimulation of preBötC increased respiratory rate, minute ventilation and increased inspiratory modulated genioglossus muscle activity...
August 15, 2015: Journal of Physiology
https://www.readbyqxmd.com/read/25664539/dynamic-mechanical-assessment-of-muscle-hyperalgesia-in-humans-the-dynamic-algometer
#14
Sara Finocchietti, Thomas Graven-Nielsen, Lars Arendt-Nielsen
BACKGROUND: Musculoskeletal pain is often associated with a nonhomogeneous distribution of mechanical hyperalgesia. Consequently, new methods able to detect this distribution are needed. OBJECTIVE: To develop and test a new method for assessing muscle hyperalgesia with high temporal and spatial resolution that provides complementary information compared with information obtained by traditional static pressure algometry. METHODS: The dynamic pressure algometer was tested bilaterally on the tibialis anterior muscle in 15 healthy subjects and compared with static pressure algometry...
January 2015: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/25652926/bilateral-force-transients-in-the-upper-limbs-evoked-by-single-pulse-microstimulation-in-the-pontomedullary-reticular-formation
#15
Thomas J Hirschauer, John A Buford
Neurons in the pontomedullary reticular formation (PMRF) give rise to the reticulospinal tract. The motor output of the PMRF was investigated using stimulus-triggered averaging of electromyography (EMG) and force recordings in two monkeys (M. fascicularis). EMG was recorded from 12 pairs of upper limb muscles, and forces were detected using two isometric force-sensitive handles. Of 150 stimulation sites, 105 (70.0%) produced significant force responses, and 139 (92.5%) produced significant EMG responses. Based on the average flexor EMG onset latency of 8...
April 1, 2015: Journal of Neurophysiology
https://www.readbyqxmd.com/read/25411494/differential-effects-of-delayed-aging-on-phenotype-and-striatal-pathology-in-a-murine-model-of-huntington-disease
#16
Sara J Tallaksen-Greene, Marianna Sadagurski, Li Zeng, Roseanne Mauch, Matthew Perkins, Varuna C Banduseela, Andrew P Lieberman, Richard A Miller, Henry L Paulson, Roger L Albin
The common neurodegenerative syndromes exhibit age-related incidence, and many Mendelian neurodegenerative diseases exhibit age-related penetrance. Mutations slowing aging retard age related pathologies. To assess whether delayed aging retards the effects of a mutant allele causing a Huntington's disease (HD)-like syndrome, we generated compound mutant mice, placing a dominant HD knock-in polyglutamine allele onto the slow-aging Snell dwarf genotype. The Snell genotype did not affect mutant huntingtin protein expression...
November 19, 2014: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/25348330/becker-muscular-dystrophy-severity-is-linked-to-the-structure-of-dystrophin
#17
Aurélie Nicolas, Céline Raguénès-Nicol, Rabah Ben Yaou, Sarah Ameziane-Le Hir, Angélique Chéron, Véronique Vié, Mireille Claustres, France Leturcq, Olivier Delalande, Jean-François Hubert, Sylvie Tuffery-Giraud, Emmanuel Giudice, Elisabeth Le Rumeur
In-frame exon deletions of the Duchenne muscular dystrophy (DMD) gene produce internally truncated proteins that typically lead to Becker muscular dystrophy (BMD), a milder allelic disorder of DMD. We hypothesized that differences in the structure of mutant dystrophin may be responsible for the clinical heterogeneity observed in Becker patients and we studied four prevalent in-frame exon deletions, i.e. Δ45-47, Δ45-48, Δ45-49 and Δ45-51. Molecular homology modelling revealed that the proteins corresponding to deletions Δ45-48 and Δ45-51 displayed a similar structure (hybrid repeat) than the wild-type dystrophin, whereas deletions Δ45-47 and Δ45-49 lead to proteins with an unrelated structure (fractional repeat)...
March 1, 2015: Human Molecular Genetics
https://www.readbyqxmd.com/read/25232145/phthalate-exposure-in-utero-causes-epigenetic-changes-and-impairs-insulin-signalling
#18
Parsanathan Rajesh, Karundevi Balasubramanian
Di-(2-ethylhexyl)phthalate (DEHP) is an endocrine-disrupting chemical (EDC), widely used as a plasticiser. Developmental exposure to EDCs could alter epigenetic programming and result in adult-onset disease. We investigated whether DEHP exposure during development affects glucose homoeostasis in the F1 offspring as a result of impaired insulin signal transduction in gastrocnemius muscle. Pregnant Wistar rats were administered DEHP (0, 1, 10 and 100 mg/kg per day) from embryonic days 9-21 orally. DEHP-exposed offspring exhibited elevated blood glucose, impaired serum insulin, glucose tolerance and insulin tolerance, along with reduced insulin receptor, glucose uptake and oxidation in the muscle at postnatal day 60...
October 2014: Journal of Endocrinology
https://www.readbyqxmd.com/read/24942380/phototherapy-in-skeletal-muscle-performance-and-recovery-after-exercise-effect-of-combination-of-super-pulsed-laser-and-light-emitting-diodes
#19
RANDOMIZED CONTROLLED TRIAL
Fernanda Colella Antonialli, Thiago De Marchi, Shaiane Silva Tomazoni, Adriane Aver Vanin, Vanessa dos Santos Grandinetti, Paulo Roberto Vicente de Paiva, Henrique Dantas Pinto, Eduardo Foschini Miranda, Paulo de Tarso Camillo de Carvalho, Ernesto Cesar Pinto Leal-Junior
Recent studies with phototherapy have shown positive results in enhancement of performance and improvement of recovery when applied before exercise. However, several factors still remain unknown such as therapeutic windows, optimal treatment parameters, and effects of combination of different light sources (laser and LEDs). The aim of this study was to evaluate the effects of phototherapy with the combination of different light sources on skeletal muscle performance and post-exercise recovery, and to establish the optimal energy dose...
November 2014: Lasers in Medical Science
https://www.readbyqxmd.com/read/24800649/skin-lesions-and-inoculation-eschars-at-the-tick-bite-site-in-spotted-fever-group-rickettsioses-experience-from-a-patient-series-in-eastern-crete-greece
#20
Antonis Germanakis, Dimosthenis Chochlakis, Emmanouil Angelakis, Yannis Tselentis, Anna Psaroulaki
The main clinical signs and symptoms caused by a rickettsial infection typically begin 6-10 days after the bite and are accompanied by nonspecific findings such as fever, headache and muscle pain. The diagnosis is mainly based on serological tests, however antibody presentation may be delayed, at least at the early stages of the disease, while seroconversion is usually detected 10-15 days after disease onset. Culture is difficult, requires optimized facilities and often proves negative. Under this scope, the presence of a characteristic inoculation eschar at the bite site may prove a useful clinical tool towards the early suspicion and diagnosis/differential diagnosis of tick-borne rickettsioses, even before the onset of rash and fever or serological confirmation...
2014: Dermatology: International Journal for Clinical and Investigative Dermatology
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