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Oncology and hematology

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https://www.readbyqxmd.com/read/29651606/age-related-apparent-diffusion-coefficients-of-lumbar-vertebrae-in-healthy-children-at-1-5-t
#1
Alexander Tschischka, Christoph Schleich, Johannes Boos, Markus Eichner, Jörg Schaper, Joel Aissa, Gerald Antoch, Dirk Klee
BACKGROUND: Diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient (ADC) calculation is important for detecting bone marrow pathologies. OBJECTIVE: To investigate age-related differences of lumbar vertebral body ADC to establish normal values for healthy children. MATERIALS AND METHODS: Forty-nine healthy children without any history of oncological or hematological diseases (10.2±4.7 years, range: 0-20 years) were included in this retrospective study...
April 13, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29650686/use-of-direct-oral-anticoagulants-in-patients-with-cancer-practical-considerations-for-the-management-of-patients-with-nausea-or-vomiting
#2
REVIEW
Hanno Riess, Cihan Ay, Rupert Bauersachs, Cecilia Becattini, Jan Beyer-Westendorf, Francis Cajfinger, Ian Chau, Alexander T Cohen, Alok A Khorana, Anthony Maraveyas, Marcos Renni, Annie M Young
Direct oral anticoagulants (DOACs) have proven efficacy and safety and are approved for use in the prevention and treatment of thromboembolic events in patients with venous thromboembolism (VTE) and those with atrial fibrillation (AF). There is no clear guidance on the use of DOACs in the significant proportion of these patients who have or will develop concomitant cancer. The occurrence of nausea and vomiting in these patients, despite implementation of guideline-recommended antiemetic strategies, is a particular concern because it may affect oral drug intake and consequently outcomes with anticoagulation therapy...
April 12, 2018: Oncologist
https://www.readbyqxmd.com/read/29649925/validity-and-reliability-of-the-turkish-version-of-the-adapted-rhodes-index-of-nausea-and-vomiting-for-pediatrics-by-child-arinvc-and-by-parent-arinvp
#3
Nurdan Akçay Didişen, Betül Yavuz, Figen Yardimci, D Zümrüt Basbakkal
The study was conducted methodologically to adapt the Adapted Rhodes Index of Nausea and Vomiting for Pediatrics by Child (ARINVc) and Adapted Rhodes Index of Nausea and Vomiting for Pediatrics by Parent (ARINVp) into Turkish. The scales are administered to children who receive chemotherapy and to their parents, respectively. The study sample consisted of 8- to 18-year-old children who were hospitalized in the pediatric oncology and hematology clinics of a university hospital, met the sampling criteria, and agreed to participate in the research...
April 1, 2018: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/29649549/bloodstream-infections-in-cancer-patients-risk-factors-associated-with-mortality
#4
Beda Islas-Muñoz, Patricia Volkow-Fernández, Cynthia Ibanes-Gutiérrez, Alberto Villamar-Ramírez, Diana Vilar-Compte, Patricia Cornejo-Juárez
OBJECTIVE: The aim of this study was to evaluate the clinical characteristics and risk factors associated with mortality in cancer patients with bloodstream infections (BSI), analyzing multidrug resistant bacteria (MDRB). METHODS: We conducted a prospective observational study at a cancer referral center from August 2016 to July 2017, which included all BSI. RESULTS: 4,220 patients were tested with blood cultures; 496 were included. Mean age was 48 years...
April 9, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29649402/end-of-life-treatments-in-pediatric-patients-at-a-government-tertiary-cancer-center-in-india
#5
Jean Jacob, Jaskirt K Matharu, Gayatri Palat, Sudha Sinha, Eva Brun, Thomas Wiebe, Mikael Segerlantz
AIM: The primary objective of this study was to describe demographics and end-of-life treatments of children with cancer at a government tertiary cancer center in India. METHODS: A retrospective review was undertaken of medical charts of all children younger than 18 years, who died as inpatients while undergoing treatment at the pediatric oncology department between April and September 2016. Data were collected on demographics, diagnosis, treatments, survival, palliative care involvement, and symptoms at end of life...
March 20, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29629655/impact-and-barriers-of-an-hiv-rapid-test-program-implementation-at-an-oncological-referral-center-in-mexico
#6
Martin-Onraet Alexandra, Perez-Jimenez Carolina, Gonzalez-Rodriguez Andrea, Volkow-Fernandez Patricia
The aim of this study was to evaluate the implementation of human immunodeficiency virus (HIV) screening with rapid tests in an oncologic center in Mexico City, report the HIV prevalence, and describe contacts screening and linkage to HIV care while identifying barriers to the performance of the program. In 2014, an HIV rapid test program was implemented in four departments of the hospital "Instituto Nacional de Cancerología". From 2014 to 2016, 3032 HIV rapid tests were performed in the hospital...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29629361/complications-of-port-a-caths-in-children-with-hematologic-oncologic-diseases
#7
COMMENT
Mohamed Zouari, Hamdi Louati, Mohamed Jallouli, Riadh Mhiri
No abstract text is available yet for this article.
March 2018: Vascular Specialist International
https://www.readbyqxmd.com/read/29623849/cardiac-imaging-in-systemic-diseases-what-the-clinician-should-know
#8
Cesar J Herrera, Pamela Pina Santana, Jorge Martinez, Mario J Garcia
IMPORTANCE: Systemic diseases that affect the cardiovascular system constitute a diagnostic and therapeutic challenge for all specialists involved; imaging tools along with clinical suspicion play an essential role in their evaluation. These entities share neurological, immunological, renal, hematologic, oncologic, infectious and endocrine processes, all of which may have associated cardiac involvement. OBSERVATIONS: Recent advances in cardiac ultrasound, computed tomography (CT), cardiac magnetic resonance (CMR) and nuclear scintigraphy have impacted the management of these conditions when involving the heart since they provide valuable anatomical and functional information while avoiding the use of invasive techniques...
April 5, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29623404/-biobanking-requirements-from-the-perspective-of-the-clinician-experiences-in-hematology-and-oncology
#9
REVIEW
S Koschmieder, T H Brümmendorf
The requirements for optimal biobanking from the point of view of the clinical partner can be highly variable. Depending on the material, processing, storage conditions, clinical data, and involvement of external partners, there will be special requirements for the participating clinician and specialist areas. What they all have in common is that the goal of any biobanking must be to improve clinical, translational, and basic research. While in the past biomaterials often had to be individually stored for each research project, modern biobanking offers decisive advantages: a comprehensive ethics vote fulfilling state-of-the-art data safety requirements, standardized processing and storage protocols, specialized biobank software for pseudonymization and localization, protection against power failures and defects of the equipment, centralized and sustainable storage, easy localization and return of samples, and their destruction or anonymization after completion of an individual project...
April 5, 2018: Der Pathologe
https://www.readbyqxmd.com/read/29616598/knowledge-beliefs-and-behaviors-related-to-palliative-care-delivery-among-pediatric-oncology-health-care-providers
#10
Jessica L Spruit, Cynthia J Bell, Valerie B Toly, Maryjo Prince-Paul
The care of pediatric patients with cancer and their families is complex and rapidly evolving. Despite significant advances in outcomes, symptoms of the disease and complications of therapy continue to cause suffering that may improve with the involvement of pediatric palliative care (PPC) services. This descriptive study responds to the observation of great variability in PPC utilization within pediatric oncology. Data collected from 156 health care professionals (nurses, advanced practice professionals, and physicians) from a statewide hematology alliance evaluates the knowledge, beliefs, and perceived barriers to PPC involvement...
April 1, 2018: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/29607820/assessment-of-sunitinib-alternative-prescription-schedules-in-metastatic-kidney-cancer-a-study-of-10-cases
#11
Habib Diallo, Hasnae Alaoui Mhamdi, Salma Elouarzazi, Mohamed Fadli, Rhizlane Belbaraka
BACKGROUND: Managing metastatic Renal Cell Carcinoma (mRCC) has been revolutionized during the first decade of the 21st century due to the development of targeted therapies. The sunitinib is an oral multi-targeted receptor Tyrosine Kinase Inhibitor (TKI). It became the first targeted therapy as first-line treatment to improve the survival of patients with metastatic kidney cancer. This treatment consists in the oral intake of 50 mg of sunitinib per day in a 6 -week cycle including 4 weeks of treatment intake (the "on" week) followed by a 2-week break (the off week)...
January 2018: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29607376/test-retest-reliability-of-the-short-form-survivor-unmet-needs-survey
#12
Karen Taylor, Max Bulsara, Leanne Monterosso
Objective: Reliable and valid needs assessment measures are important assessment tools in cancer survivorship care. A new 30-item short-form version of the Survivor Unmet Needs Survey (SF-SUNS) was developed and validated with cancer survivors, including hematology cancer survivors; however, test-retest reliability has not been established. The objective of this study was to assess the test-retest reliability of the SF-SUNS with a cohort of lymphoma survivors ( n = 40). Methods: Test-retest reliability of the SF-SUNS was conducted at two time points: baseline (time 1) and 5 days later (time 2)...
April 2018: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29607231/a-rare-case-report-a-malignant-histiocytic-tumor-in-the-form-of-ovarian-mass
#13
Emsal Pinar Topdagi Yilmaz, Yakup Kumtepe, Yunus Emre Topdagi, Seray Kaya Topdagi
Histiocytic cell malignancies are very rare. Hence, the information about this disease in hematology is limited. In this case report, we present a case of malignant histiocytic tumor affecting the ovary of a 40-year-old virgin female. Primary ovarian malignancy was not considered for the patient who was approached as if she had ovarian malignancy, since there was an indication of a mass in the ovary. Therefore, an aggressive surgery was not performed. Since our patient was in the reproductive age, fertility-preserving surgery was performed...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29603868/american-society-of-pediatric-hematology-oncology-aspho-david-l-lawrence-convention-center-pittsburgh-pa-may-2-5-2018
#14
(no author information available yet)
No abstract text is available yet for this article.
June 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29603386/natural-history-of-myocardial-deformation-in-children-adolescents-and-young-adults-exposed-to-anthracyclines-systematic-review-and-meta-analysis
#15
Mirela Tuzovic, Pei-Tzu Wu, Samuel Kianmahd, Kim-Lien Nguyen
OBJECTIVE: Anthracyclines are widely used to treat solid and hematologic malignancies, but are known to cause cardiotoxicity. As more childhood cancer survivors reach adulthood due to improvements in oncologic treatments, they become susceptible to late and progressive anthracycline-induced cardiotoxicity. Nonetheless, diagnostic criteria for early detection of cardiac dysfunction are not well defined in children, adolescent, and young adults (CAYA, ages 1-40 years). We present a natural history of the changes in myocardial deformation in CAYA patients after anthracycline therapy...
March 30, 2018: Echocardiography
https://www.readbyqxmd.com/read/29589346/-recommendations-for-diagnostics-and-therapy-of-children-with-cancer-presenting-with-fever-and-neutropenia-comparison-of-two-current-guidelines
#16
Thomas Lehrnbecher, Andreas Groll, Philipp Agyeman, Roland A Ammann, Andishe Attarbaschi, Uta Behrends, Christoph Berger, Axel Hamprecht, Markus Hufnagel, Hans-Jürgen Laws, Max Scheler, Christian Temme, Simon Vieth, Arne Simon
Immunocompromised children and adolescents receiving treatment for cancer have a considerably increased risk for infection. Neutropenia is the most important single risk factor for infectious complications, and fever in neutropenia is considered as an emergency. Whereas guidelines for the management of fever in neutropenic adults have been established for decades, specific pediatric guidelines have not been developed until recently. As children differ in many aspects from adults such as in the underlying malignancy or in the availability and dosing of antimicrobial compounds, guidelines for pediatric patients are important...
March 27, 2018: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29589223/an-analysis-of-the-inclusion-of-medications-considered-potentially-inappropriate-in-older-adults-in-chemotherapy-templates-for-hematologic-malignancies-one-recommendation-for-all
#17
Amy Zhou, Holly M Holmes, Arti Hurria, Tanya M Wildes
BACKGROUND: There remains a paucity of data regarding the use of potentially inappropriate medications (PIMs) in the supportive management of older adults undergoing chemotherapy. Raising awareness among healthcare providers regarding the frequency of their use and potential toxicities may help to minimize the risks to patients. OBJECTIVE: The aim of this study was to evaluate the frequency of six specific classes of medications considered PIMs by the American Geriatrics Society Beers Criteria that are commonly included in the National Comprehensive Cancer Network (NCCN) chemotherapy order templates for hematologic malignancies...
March 27, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29582941/-the-new-hadassah-hebrew-university-medical-center-a-leader-in-israeli-public-medicine
#18
Dror Mevorach, Meir Leibergall, Zeev Rothstein
Hadassah-Hebrew University Medical Center is regaining its lead in Israeli public medicine with clinical excellence, state-of-the art technology, high achievement in research, and outstanding medical education for students and trainees. Hadassah has two campuses at Ein Kerem and Mount Scopus that together offer 1200-hospital beds and 40 hybrid and advanced operating rooms. Hadassah Medical Center, an initiative of Hadassah organization led by Henrietta Szold, is one of the foremost health care providers in Israel...
March 2018: Harefuah
https://www.readbyqxmd.com/read/29574603/nationwide-survey-of-therapy-related-leukemia-in-childhood-in-japan
#19
Toshihiko Imamura, Takashi Taga, Masatoshi Takagi, Hirohide Kawasaki, Katsuyoshi Koh, Tomohiko Taki, Souichi Adachi, Atsushi Manabe, Yasushi Ishida
Therapy-related leukemia (t-leukemia) is associated with dismal prognosis. Published pediatric t-leukemia data are somewhat outdated and may not reflect recent advances in treatment. We report a retrospective nationwide survey of patients diagnosed between 2000 and 2013 in Japan. We identified 43 patients with pediatric t-leukemia; 33 had t-acute myeloid leukemia (t-AML), eight had t-acute lymphoblastic leukemia (t-ALL) and two had t-acute undifferentiated leukemia. Median age at onset and latency were 12 years and 3...
March 24, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29572239/identification-of-novel-mecom-gene-fusion-and-personalized-therapeutic-targets-through-integrative-clinical-sequencing-in-secondary-acute-myeloid-leukemia-in-a-patient-with-severe-congenital-neutropenia-a-case-report-and-literature-review
#20
James A Connelly, Rajen J Mody, Yi-Mi Wu, Dan R Robinson, Robert J Lonigro, Pankaj Vats, Erica Rabban, Bailey Anderson, Kelly Walkovich
Severe congenital neutropenia (SCN) is a rare hematologic disorder characterized by defective myelopoiesis and a high incidence of malignant transformation to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). SCN patients who develop MDS/AML have excessive toxicities to traditional chemotherapy and safer therapies are needed to improve overall survival in this population. In this report, we outline the use of a prospective integrative clinical sequencing trial (PEDS-MIONCOSEQ) in a patient with SCN and AML to help identify oncogenic targets for less toxic agents...
March 23, 2018: Cold Spring Harbor Molecular Case Studies
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