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MT2A gene

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https://www.readbyqxmd.com/read/27477335/metallothionein-prevents-age-associated-cardiomyopathy-via-inhibiting-nf-%C3%AE%C2%BAb-pathway-activation-and-associated-nitrative-damage-to-2-ogd
#1
Weitao Cong, Chao Niu, Lingchun Lv, Maowei Ni, Dandan Ruan, Lisha Chi, Yang Wang, Qing Yu, Kungao Zhan, Yuanhu Xuan, Yuehui Wang, Yi Tan, Tiemin Wei, Lu Cai, Litai Jin
AIMS: Cardiac-specific metallothionein (MT) overexpression extends lifespan, but the mechanism underlying the effect of MT protection against age-associated cardiovascular diseases (CVD) remains elusive. To elucidate this, male wild-type and two lines of MT-transgenic (MT-TG) mice, MM and MT-1 (cardiac-specific overexpressing MT about 10- and 80-fold, respectively) at three representative ages (2-3, 9-10, and 18-20 months), were utilized. A stable human MT2A overexpressing cardiomyocytes (H9c2MT7) was also introduced...
December 10, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/27256343/pathways-and-gene-networks-mediating-the-regulatory-effects-of-cannabidiol-a-nonpsychoactive-cannabinoid-in-autoimmune-t-cells
#2
Ewa Kozela, Ana Juknat, Fuying Gao, Nathali Kaushansky, Giovanni Coppola, Zvi Vogel
BACKGROUND: Our previous studies showed that the non-psychoactive cannabinoid, cannabidiol (CBD), ameliorates the clinical symptoms in mouse myelin oligodendrocyte glycoprotein (MOG)35-55-induced experimental autoimmune encephalomyelitis model of multiple sclerosis (MS) as well as decreases the memory MOG35-55-specific T cell (TMOG) proliferation and cytokine secretion including IL-17, a key autoimmune factor. The mechanisms of these activities are currently poorly understood. METHODS: Herein, using microarray-based gene expression profiling, we describe gene networks and intracellular pathways involved in CBD-induced suppression of these activated memory TMOG cells...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27122239/metallothionein-mt2a-a-5g-polymorphism-as-a-risk-factor-for-chronic-kidney-disease-and-diabetes-cross-sectional-and-cohort-studies
#3
Yuta Hattori, Mariko Naito, Masahiko Satoh, Masahiro Nakatochi, Hisao Naito, Masashi Kato, Sahoko Takagi, Takashi Matsunaga, Toshio Seiki, Tae Sasakabe, Shino Suma, Sayo Kawai, Rieko Okada, Asahi Hishida, Nobuyuki Hamajima, Kenji Wakai
Metallothioneins (MTs) are proteins that protect cells from toxic agents such as heavy metal ions or reactive oxygen species. MT2A A-5G is a single nucleotide polymorphism in the promoter region of the MT2A gene, and the minor G allele results in lower transcription efficiency. We aimed to elucidate associations between MT2A A-5G and risks of 2 diseases potentially related to lowered MT expression, chronic kidney disease (CKD), and diabetes mellitus (DM), in a community-dwelling population. Study subjects were Nagoya city residents participating in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC) Daiko Study, comprised 749 men and 2,025 women, aged 39-75 years...
July 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27038574/an-emphasis-of-hydrogen-sulfide-cysteine-cycle-on-enhancing-the-tolerance-to-chromium-stress-in-arabidopsis
#4
Huihui Fang, Zhiqiang Liu, Zhuping Jin, Liping Zhang, Danmei Liu, Yanxi Pei
Increasing attention has been focused on the health of vegetables and grains grown in the contaminated agricultural soil, it is thus meaningful to find ways to reduce the heavy metals (HMs) accumulation in plants. As sulfur is considered to be an essential macronutrient for plant stress defenses, the important role of sulfur assimilation in plants responding to HMs stress has been followed. However, the potential mechanism of the only sulfur-containing gasotransmitter hydrogen sulfide (H2S) and its main endogenously generated substrate, cysteine (Cys), in plant defense is poorly understood...
June 2016: Environmental Pollution
https://www.readbyqxmd.com/read/26973856/in-silico-and-experimental-analyses-predict-the-therapeutic-value-of-an-ezh2-inhibitor-gsk343-against-hepatocellular-carcinoma-through-the-induction-of-metallothionein-genes
#5
Tsang-Pai Liu, Yi-Han Hong, Kwang-Yi Tung, Pei-Ming Yang
There are currently no effective molecular targeted therapies for hepatocellular carcinoma (HCC), the third leading cause of cancer-related death worldwide. Enhancer of zeste homolog 2 (EZH2), a histone H3 lysine 27 (H3K27)-specific methyltransferase, has been emerged as novel anticancer target. Our previous study has demonstrated that GSK343, an S-adenosyl-L-methionine (SAM)-competitive inhibitor of EZH2, induces autophagy and enhances drug sensitivity in cancer cells including HCC. In this study, an in silico study was performed and found that EZH2 was overexpressed in cancerous tissues of HCC patients at both gene and protein levels...
2016: Oncoscience
https://www.readbyqxmd.com/read/26881174/eola1-inhibits-lipopolysaccharide-induced-vascular-cell-adhesion-molecule-1-expression-by-association-with-mt2a-in-ecv304-cells
#6
Weiling Leng, Xiaotian Lei, Hao Meng, Xinshou Ouyang, Ziwen Liang
Our research group firstly discovered endothelial-overexpressed lipopolysaccharide-associated factor 1 (EOLA1, GenBank number AY074889) as a lipopolysaccharide (LPS) responsive gene in ECV304 cells. The previous studies have further demonstrated the association of EOLA1 with metallothionein 2A (MT2A), while the role of EOLA1 during LPS-induced inflammatory response in ECV304 cells is unknown. In this report, we determined the subcellular localization of EOLA1 and the regulatory capacity of EOLA1 on vascular cell adhesion molecule-1 (VCAM-1) in response to LPS in ECV304 cells...
2015: International Journal of Inflammation
https://www.readbyqxmd.com/read/26688266/dna-methylation-is-differentially-associated-with-environmental-cadmium-exposure-based-on-sex-and-smoking-status
#7
Shama Virani, Katie M Rentschler, Muneko Nishijo, Werawan Ruangyuttikarn, Witaya Swaddiwudhipong, Niladri Basu, Laura S Rozek
The adverse health effects of cadmium (Cd) are well known in human populations; however, much of what is known about biological mechanisms of Cd comes from in vitro and animal studies. The adverse health outcomes due to high levels of Cd exposure in the population of Mae Sot, Thailand have been extensively characterized. Here, for the first time, this population is being studied in an epigenetic context. The objective of this study was to characterize the association between DNA methylation markers and Cd exposure, taking into account sex and smoking differences, in an adult population at an increased risk of experiencing adverse health outcomes from high body burden of Cd...
February 2016: Chemosphere
https://www.readbyqxmd.com/read/26666815/effect-of-hpv-on-tumor-expression-levels-of-the-most-commonly-used-markers-in-hnscc
#8
Hana Polanska, Zbynek Heger, Jaromir Gumulec, Martina Raudenska, Marketa Svobodova, Jan Balvan, Michaela Fojtu, Hana Binkova, Zuzana Horakova, Rom Kostrica, Vojtech Adam, Rene Kizek, Michal Masarik
Approximately 90 % of head and neck cancers are squamous cell carcinomas (HNSCC), and the overall 5-year survival rate is not higher than 50 %. There is much evidence that human papillomavirus (HPV) infection may influence the expression of commonly studied HNSCC markers. Our study was focused on the possible HPV-specificity of molecular markers that could be key players in important steps of cancerogenesis (MKI67, EGF, EGFR, BCL-2, BAX, FOS, JUN, TP53, MT1A, MT2A, VEGFA, FLT1, MMP2, MMP9, and POU5F). qRT-PCR analysis of these selected genes was performed on 74 biopsy samples of tumors from patients with histologically verified HNSCC (22 HPV-, 52 HPV+)...
June 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26594907/polymorphism-of-metallothionein-2a-modifies-lead-body-burden-in-workers-chronically-exposed-to-the-metal
#9
Kelly Christine Marques Fernandes, Airton Cunha Martins, Andréia Ávila Soares de Oliveira, Lusânia Maria Greggi Antunes, Ilce Mara de Syllos Cólus, Fernando Barbosa, Gustavo Rafael Mazzaron Barcelos
Lead (Pb) is a metal that accumulates in the human body, inducing several adverse health effects. One of the proteins responsible for the distribution of metal in the body is metallothionein (MT), which is expressed by different genes, and it is supposed that genetic variation in the genes that encode MTs may affect the Pb body burden. The present study aimed to evaluate the genetic effects of the polymorphism of MT2A (single nucleotide polymorphism rs10636; Cx2192;G) on blood Pb levels (BLL) of workers from car battery factories who are chronically exposed to the metal...
2016: Public Health Genomics
https://www.readbyqxmd.com/read/26529669/genetic-variation-in-metallothionein-and-metal-regulatory-transcription-factor-1-in-relation-to-urinary-cadmium-copper-and-zinc
#10
Scott V Adams, Brian Barrick, Emily P Christopher, Martin M Shafer, Karen W Makar, Xiaoling Song, Johanna W Lampe, Hugo Vilchis, April Ulery, Polly A Newcomb
BACKGROUND: Metallothionein (MT) proteins play critical roles in the physiological handling of both essential (Cu and Zn) and toxic (Cd) metals. MT expression is regulated by metal-regulatory transcription factor 1 (MTF1). Hence, genetic variation in the MT gene family and MTF1 might influence excretion of these metals. METHODS: 321 women were recruited in Seattle, WA and Las Cruces, NM and provided demographic information, urine samples for measurement of metal concentrations by mass spectrometry and creatinine, and blood or saliva for extraction of DNA...
December 15, 2015: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/26398855/screening-and-verification-of-proteins-that-interact-with-hspc238
#11
Jia-Yu Tan, Jing-Lin Chen, Xiang Huang, Chun-Lei Yuan
HSPC238 is a recently identified tumor suppressor and demonstrates ubiquitin ligase E3 enzyme activity. HSPC238 was found to be significantly downregulated in human hepatocellular carcinoma (HCC) in vivo and to inhibit the proliferation and invasion of hepatoma cells in vitro; however, the underlying molecular mechanism is largely unknown. In the present study, we screened for and identified proteins that physically interact with HSPC238. A bait vector for yeast two-hybrid was constructed with human HSPC238 gene cDNA...
December 2015: Oncology Reports
https://www.readbyqxmd.com/read/26378417/zerovalent-fe-co-and-ni-nanoparticle-toxicity-evaluated-on-skov-3-and-u87-cell-lines
#12
Rosalba Gornati, Elisa Pedretti, Federica Rossi, Francesca Cappellini, Michela Zanella, Iolanda Olivato, Enrico Sabbioni, Giovanni Bernardini
We have considered nanoparticles (NPs) of Fe, Co and Ni, three transition metals sharing similar chemical properties. NP dissolution, conducted by radioactive tracer method and inductively coupled plasma mass spectrometry, indicated that NiNPs and FeNPs released in the medium a much smaller amount of ions than that released by Co NPs. The two considered methodological approaches, however, gave comparable but not identical results. All NPs are readily internalized by the cells, but their quantity inside the cells is less than 5%...
March 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/26168959/prognostic-significance-of-the-tumour-adjacent-tissue-in-head-and-neck-cancers
#13
Martina Raudenska, Marketa Sztalmachova, Jaromir Gumulec, Michaela Fojtu, Hana Polanska, Jan Balvan, Marek Feith, Hana Binkova, Zuzana Horakova, Rom Kostrica, Rene Kizek, Michal Masarik
Even with significant advances in operative skills and adjuvant therapies, the overall survival of patients suffering with head and neck squamous cancers (HNSCC) is unsatisfactory. Accordingly, no clinically useful prognostic biomarkers have been found yet for HNSCC. Many studies analysed the expression of potential markers in tumour tissues compared to adjacent tissues. Nevertheless, due to the sharing of the same microenvironment, adjacent tissues show molecular similarity to tumour tissues. Thus, gene expression patterns of 94 HNSCC tumorous tissues were compared with 31 adjacent tissues and with 10 tonsillectomy specimens of non-cancer individuals...
December 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26133168/cell-free-dna-of-tumor-origin-induces-a-metastatic-expression-profile-in-ht-29-cancer-cell-line
#14
István Fűri, Alexandra Kalmár, Barnabás Wichmann, Sándor Spisák, Andrea Schöller, Barbara Barták, Zsolt Tulassay, Béla Molnár
BACKGROUND: Epithelial cells in malignant conditions release DNA into the extracellular compartment. Cell free DNA of tumor origin may act as a ligand of DNA sensing mechanisms and mediate changes in epithelial-stromal interactions. AIMS: To evaluate and compare the potential autocrine and paracrine regulatory effect of normal and malignant epithelial cell-related DNA on TLR9 and STING mediated pathways in HT-29 human colorectal adenocarcinoma cells and normal fibroblasts...
2015: PloS One
https://www.readbyqxmd.com/read/26088140/response-element-composition-governs-correlations-between-binding-site-affinity-and-transcription-in-glucocorticoid-receptor-feed-forward-loops
#15
Sarah K Sasse, Zheng Zuo, Vineela Kadiyala, Liyang Zhang, Miles A Pufall, Mukesh K Jain, Tzu L Phang, Gary D Stormo, Anthony N Gerber
Combinatorial gene regulation through feed-forward loops (FFLs) can bestow specificity and temporal control to client gene expression; however, characteristics of binding sites that mediate these effects are not established. We previously showed that the glucocorticoid receptor (GR) and KLF15 form coherent FFLs that cooperatively induce targets such as the amino acid-metabolizing enzymes AASS and PRODH and incoherent FFLs exemplified by repression of MT2A by KLF15. Here, we demonstrate that GR and KLF15 physically interact and identify low affinity GR binding sites within glucocorticoid response elements (GREs) for PRODH and AASS that contribute to combinatorial regulation with KLF15...
August 7, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26036762/metallothionein-2a-core-promoter-region-genetic-polymorphism-and-its-impact-on-the-risk-tumor-behavior-and-recurrences-of-sinonasal-inverted-papilloma-schneiderian-papilloma
#16
Katarzyna Starska, Magdalena Bryś, Ewa Forma, Jurek Olszewski, Piotr Pietkiewicz, Iwona Lewy-Trenda, Olga Stasikowska-Kanicka, Marian Danilewicz, Anna Krześlak
Inverted papillomas are a unique group of locally aggressive benign epithelial neoplasms in the nasal cavity and paranasal sinuses arising from the Schneiderian mucosa. Metallothioneins are sulfhydryl-rich heavy metal-binding proteins required for metal toxicity protection and regulation of biological mechanisms including proliferation and invasion. The goal of this study was to identify three SNPs at loci -5 A/G (rs28366003) and -209 A/G (rs1610216) in the core promoter region and at locus +838 C/G (rs10636) in 3'UTR region of the MT2A gene with IP risk and with tumor invasiveness according to Krouse staging...
November 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/25900616/the-effect-of-metallothionein-2a-core-promoter-region-single-nucleotide-polymorphism-on-accumulation-of-toxic-metals-in-sinonasal-inverted-papilloma-tissues
#17
Katarzyna Starska, Magdalena Bryś, Ewa Forma, Jurek Olszewski, Piotr Pietkiewicz, Iwona Lewy-Trenda, Marian Danilewicz, Anna Krześlak
Metallothioneins (MTs) are intracellular thiol-rich heavy metal-binding proteins which join trace metal ions protecting cells against heavy metal toxicity and regulate metal distribution and donation to various enzymes and transcription factors. The goal of this study was to identify the -5 A/G (rs28366003) single-nucleotide polymorphism (SNP) in the core promoter region of the MT2A gene, and to investigate its effect on allele-specific gene expression and Cd, Zn, Cu and Ni content in sinonasal inverted papilloma tissue (IP), with non-cancerous sinonasal mucosa (NCM) as a control...
June 15, 2015: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/25804888/chronic-inorganic-arsenic-exposure-in-vitro-induces-a-cancer-cell-phenotype-in-human-peripheral-lung-epithelial-cells
#18
Rachel J Person, Ntube N Olive Ngalame, Ngome L Makia, Matthew W Bell, Michael P Waalkes, Erik J Tokar
Inorganic arsenic is a human lung carcinogen. We studied the ability of chronic inorganic arsenic (2 μM; as sodium arsenite) exposure to induce a cancer phenotype in the immortalized, non-tumorigenic human lung peripheral epithelial cell line, HPL-1D. After 38 weeks of continuous arsenic exposure, secreted matrix metalloproteinase-2 (MMP2) activity increased to over 200% of control, levels linked to arsenic-induced cancer phenotypes in other cell lines. The invasive capacity of these chronic arsenic-treated lung epithelial (CATLE) cells increased to 320% of control and colony formation increased to 280% of control...
July 1, 2015: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/25768320/identification-of-hepatocellular-carcinoma-associated-hub-genes-and-pathways-by-integrated-microarray-analysis
#19
Fangfeng Liu, Hongguang Li, Hong Chang, Jianlu Wang, Jun Lu
AIMS AND BACKGROUND: Hepatocellular carcinoma (HCC) is a dismal malignancy associated with multiple molecular changes. The purpose of this study was to identify the differentially expressed genes and analyze the biological processes related to HCC. METHODS AND STUDY DESIGN: Datasets of HCC were obtained from the NCBI Gene Expression Omnibus. Integrated analysis of differentially expressed genes was performed using the INMEX program. Then Gene Ontology enrichment analyses and pathway analysis were performed based on the Gene Ontology website and Kyoto Encyclopedia of Genes and Genomes...
March 2015: Tumori
https://www.readbyqxmd.com/read/25640883/metallothionein-gene-expression-is-altered-in-oral-cancer-and-may-predict-metastasis-and-patient-outcomes
#20
Marco T Brazão-Silva, Maria Fernandes S Rodrigues, Ana Lúcia A Eisenberg, Fernando L Dias, Luciana M de Castro, Fábio D Nunes, Paulo R Faria, Sérgio V Cardoso, Adriano M Loyola, Suzana C O M de Sousa
AIMS: Metallothioneins (MTs) are proteins associated with the carcinogenesis and prognosis of various tumours. Previous studies have shown their potential as biomarkers in oral squamous cell carcinoma (OSCC). Aiming to understand more clearly the function of MTs in OSCC we evaluated, for the first time, the gene expression profile of MTs in this neoplasm. MATERIALS AND RESULTS: Tissue samples from 35 cases of tongue and/or floor of mouth OSCC, paired with their corresponding non-neoplastic oral mucosa (NNOM), were retrieved (2007-09)...
September 2015: Histopathology
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