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https://www.readbyqxmd.com/read/28343275/potential-toxic-elements-in-stream-sediments-soils-and-waters-in-an-abandoned-radium-mine-central-portugal
#1
I M H R Antunes, A M R Neiva, M T D Albuquerque, P C S Carvalho, A C T Santos, Pedro P Cunha
The Alto da Várzea radium mine (AV) exploited ore and U-bearing minerals, such as autunite and torbernite. The mine was exploited underground from 1911 to 1922, closed in 1946 without restoration, and actually a commercial area is deployed. Stream sediments, soils and water samples were collected between 2008 and 2009. Stream sediments are mainly contaminated in As, Th, U and W, which is related to the AV radium mine. The PTEs, As, Co, Cr, Sr, Th, U, W, Zn, and electrical conductivity reached the highest values in soils collected inside the mine influence...
March 25, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28342779/suppression-of-calpain-expression-by-nsaids-is-associated-with-inhibition-of-cell-migration-in-rat-duodenum
#2
Kristopher Silver, A Littlejohn, Laurel Thomas, Bhupinder Bawa, James D Lillich
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for the alleviation of pain and inflammation, but these drugs are also associated with a suite of negative side effects. Gastrointestinal (GI) toxicity is particularly concerning since it affects an estimated 70% of individuals taking NSAIDs routinely, and evidence suggests the majority of toxicity is occurring in the small intestine. Traditionally, NSAID-induced GI toxicity has been associated with indiscriminate inhibition of cyclooxygenase isoforms, but other mechanisms, including inhibition of cell migration, intestinal restitution, and wound healing, are likely to contribute to toxicity...
March 22, 2017: Toxicology
https://www.readbyqxmd.com/read/28342750/mutation-of-the-caspase-3-cleavage-site-in-the-astroglial-glutamate-transporter-eaat2-delays-disease-progression-and-extends-lifespan-in-the-sod1-g93a-mouse-model-of-als
#3
Lauren Taylor Rosenblum, Shashirekha Shamamandri-Markandaiah, Biswarup Ghosh, Emily Foran, Angelo C Lepore, Piera Pasinelli, Davide Trotti
Downregulation in the astroglial glutamate transporter EAAT2 in amyotrophic lateral sclerosis (ALS) patients and mutant SOD1 mouse models of ALS is believed to contribute to the death of motor neurons by excitotoxicity. We previously reported that caspase-3 cleaves EAAT2 at a unique cleavage consensus site located in its c-terminus domain, a proteolytic cleavage that also occurs in vivo in the mutant SOD1 mouse model of ALS and leads to accumulation of a sumoylated EAAT2 C-Terminus fragment (CTE-SUMO1) beginning around onset of disease...
March 22, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28342712/therapeutic-targets-in-the-selective-killing-of-cancer-cells-by-nanomaterials
#4
REVIEW
Mohd Javed Akhtar, Maqusood Ahamed, Hisham A Alhadlaq
Cancer is the result of numerous defects in key regulatory proteins and pathways, and targeting them with anticancer agents is associated with severe systemic toxicity. Increased levels of reactive oxygen species (ROS) and compensatory antioxidant levels in cancer cells have emerged as broad spectrum targets for therapeutic interventions. The biochemical features of cancer provide multiple but overlapping opportunities that could be efficiently exploited by the optimally engineered particulate characteristics of nanomaterials (NMs)...
March 22, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28340464/a-review-on-various-electrochemical-techniques-for-heavy-metal-ions-detection-with-different-sensing-platforms
#5
REVIEW
BabanKumar Bansod, Tejinder Kumar, Ritula Thakur, Shakshi Rana, Inderbir Singh
Heavy metal ions are non-biodegradable and contaminate most of the natural resources occurring in the environment including water. Some of the heavy metals including Lead (Pb), Mercury (Hg), Arsenic (As), Chromium (Cr) and Cadmium (Cd) are considered to be highly toxic and hazardous to human health even at trace levels. This leads to the requirement of fast, accurate and reliable techniques for the detection of heavy metal ions. This review presents various electrochemical detection techniques for heavy metal ions those are user friendly, low cost, provides on-site and real time monitoring as compared to other spectroscopic and optical techniques...
March 18, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28340420/extended-anaerobic-conditions-in-the-biological-wastewater-treatment-higher-reduction-of-toxicity-compared-to-target-organic-micropollutants
#6
Johannes Völker, Tobias Vogt, Sandro Castronovo, Arne Wick, Thomas A Ternes, Adriano Joss, Jörg Oehlmann, Martin Wagner
Extended anaerobic conditions during biological wastewater treatment may enhance the biodegradation of micropollutants. To explore this, we combined iron-reducing or substrate-limited anaerobic conditions and aerobic pilot-scale reactors directly at a wastewater treatment plant. To investigate the detoxification by these processes, we applied two in vitro bioassays for baseline toxicity (Microtox) and reactive toxicity (AREc32) as well as in vivo bioassays with aquatic model species in two laboratory experiments (Desmodesmus subspicatus, Daphnia magna) and two on-site, flow-through experiments (Potamopyrgus antipodarum, Lumbriculus variegatus)...
March 14, 2017: Water Research
https://www.readbyqxmd.com/read/28340400/pharmacoinformatics-exploration-of-polyphenol-oxidases-leading-to-novel-inhibitors-by-virtual-screening-and-molecular-dynamic-simulation-study
#7
Mubashir Hassan, Qamar Abbas, Zaman Ashraf, Ahmed A Moustafa, Sung-Yum Seo
Polyphenol oxidases (PPOs)/tyrosinases are metal-dependent enzymes and known as important targets for melanogenesis. Although considerable attempts have been conducted to control the melanin-associated diseases by using various inhibitors. However, the exploration of the best anti-melanin inhibitor without side effect still remains a challenge in drug discovery. In present study, protein structure prediction, ligand-based pharmacophore modeling, virtual screening, molecular docking and dynamic simulation study were used to screen the strong novel inhibitor to cure melanogenesis...
March 15, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28340386/constructed-ils-coated-porous-magnetic-nickel-cobaltate-hexagonal-nanoplates-sensing-materials-for-the-simultaneous-detection-of-cumulative-toxic-metals
#8
Yuanyuan Dong, Lei Zhang
The different morphologies of magnetic nickel cobaltate (NiCo2O4) electrocatalysts, consisting of nanoparticles (NiCo2O4-N), nanoplates (NiCo2O4-P) and microspheres (NiCo2O4-S) were fabricated. It was found that the electrocatalytic properties of the sensing materials were strongly dependent on morphology and specific surface area. The porous NiCo2O4 hexagonal nanoplates coupled with ILs as modified materials (ILs@NiCo2O4-P) for the simultaneous determination of thallium (Tl(+)), lead (Pb(2+)) and copper (Cu(2+)), exhibited high sensitivity, long-time stability and good repeatability...
March 18, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28340377/possible-protective-effect-of-royal-jelly-against-cyclophosphamide-induced-prostatic-damage-in-male-albino-rats-a-biochemical-histological-and-immuno-histo-chemical-study
#9
Sara Mohammed Naguib Abdel-Hafez, Rehab Ahmed Rifaai, Walaa Yehia Abdelzaher
Almost all the chemotherapy treat many cancer types effectively, but it leads to severe side effects. Chemotherapy like cyclophosphamide (CP) not works only on the active cells, such as cancer cells, but also acts on the healthy cells. Royal jelly (RJ) was reported to have a lot of therapeutic effects besides being an anti-oxidant and anti-cancer agent. The purpose of this study was to assess the possible protective role of RJ in ameliorating the toxic effects of CP overdose in the rat prostatic tissue. The rats were separated into 4 groups; control group, RJ group, CP group and RJ with CP group...
March 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28340373/influence-of-sex-on-cardiovascular-drug-responses-role-of-estrogen
#10
REVIEW
Abdel A Abdel-Rahman
In this review we discuss the sex/estrogen-specific modulation of cardiovascular function and responses to current therapeutics. We discuss how anatomical differences such as a smaller kidney size, and lower glomerular filtration rate in females, reduce the clearance and increase the toxicity of some drugs in females. Other important sex differences include the dampening effect of estrogen on central sympathetic and renin angiotensin systems. Further, we discuss how a shift in myocardial redox status leads to paradoxical transformation of estrogen into a pro-inflammatory hormone...
March 21, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28339967/placental-transporter-localization-and-expression-in-the-human-the-importance-of-species-sex-and-gestational-age-differences1
#11
Natasha Walker, Panagiotis Filis, Ugo Soffientini, Michelle Bellingham, Peter J O'Shaughnessy, Paul A Fowler
The placenta is a critical organ during pregnancy, essential for the provision of an optimal intrauterine environment, with fetal survival, growth and development relying on correct placental function. It must allow nutritional compounds and relevant hormones to pass into the fetal bloodstream and metabolic waste products to be cleared. It also acts as a semi-permeable barrier to potentially harmful chemicals both endogenous and exogenous. Transporter proteins allow for bidirectional transport and are found in the syncytiotrophoblast of the placenta and endothelium of fetal capillaries...
March 7, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28339564/emerging-molecular-therapies-targeting-myocardial-infarction-related-arrhythmias
#12
Helen E Driessen, Toon A B van Veen, Gerard J J Boink
Cardiac disease is the leading cause of death in the developed world. Ventricular arrhythmias associated with myocardial ischaemia and/or infarction are a major contributor to cardiovascular mortality, and require improved prevention and treatment. Drugs, devices, and radiofrequency catheter ablation have made important inroads, but have significant limitations ranging from incomplete success to undesired toxicities and major side effects. These limitations derive from the nature of the intervention. Drugs are frequently ineffective, target the entire heart, and often do not deal with the specific arrhythmia trigger or substrate...
October 6, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339347/the-aging-kidney-and-the-nephrotoxic-effects-of-mercury
#13
Christy C Bridges, Rudolfs K Zalups
Owing to advances in modern medicine, life expectancies are lengthening and leading to an increase in the population of older individuals. The aging process leads to significant alterations in many organ systems, with the kidney being particularly susceptible to age-related changes. Within the kidney, aging leads to ultrastructural changes such as glomerular and tubular hypertrophy, glomerulosclerosis, and tubulointerstitial fibrosis, which may compromise renal plasma flow (RPF) and glomerular filtration rate (GFR)...
2017: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/28339049/kidney-and-heavy-metals-the-role-of-environmental-exposure-review
#14
Paolo Lentini, Luca Zanoli, Antonio Granata, Salvatore Santo Signorelli, Pietro Castellino, Roberto Dell'Aquila
Heavy metals are extensively used in agriculture and industrial applications such as production of pesticides, batteries, alloys, and textile dyes. Prolonged, intensive or excessive exposure can induce related systemic disorders. Kidney is a target organ in heavy metal toxicity for its capacity to filter, reabsorb and concentrate divalent ions. The extent and the expression of renal damage depends on the species of metals, the dose, and the time of exposure. Almost always acute kidney impairment differs from chronic renal failure in its mechanism and in the magnitude of the outcomes...
March 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28339013/immunological-effects-of-occupational-exposure-to-lead-review
#15
Concettina Fenga, Silvia Gangemi, Valentina Di Salvatore, Luca Falzone, Massimo Libra
It is well-known that occupational and environmental exposure to several factors, including benzene, heavy metals, chemicals and mineral fibers, is associated with the risk of developing a great number of diseases. Numerous studies have been carried out in order to investigate the mechanisms of toxicity of these substances, with particular regard to the possible toxic effects on the immune system. However, little is known about the influence of heavy metals, such as lead, on the immune system in human populations...
March 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28338291/versatile-polymer-nanoparticles-as-two-photon-triggered-photosensitizers-for-simultaneous-cellular-deep-tissue-imaging-and-photodynamic-therapy
#16
Liang Guo, Jiechao Ge, Qian Liu, Qingyan Jia, Hongyan Zhang, Weimin Liu, Guangle Niu, Sha Liu, Jianru Gong, Steffen Hackbarth, Pengfei Wang
Clinical applications of current photodynamic therapy (PDT) photosensitizers (PSs) are often limited by their absorption in the UV-vis range that possesses limited tissue penetration ability, leading to ineffective therapeutic response for deep-seated tumors. Alternatively, two-photon excited PS (TPE-PS) using NIR light triggered is one the most promising candidates for PDT improvement. Herein, multimodal polymer nanoparticles (PNPs) from polythiophene derivative as two-photon fluorescence imaging as well as two-photon-excited PDT agent are developed...
March 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28338137/an-investigation-of-the-pm2-5-and-no2-concentrations-and-their-human-health-impacts-in-the-metro-subway-system-of-suzhou-china
#17
Shi-Jie Cao, Xiang-Ri Kong, Linyan Li, Weirong Zhang, Zi-Ping Ye, Yelin Deng
This study measured the particle concentrations with an aerodynamic diameter smaller than 2.5 μm (PM2.5), nitrogen dioxide (NO2), and relative humidity (RH) at five metro subway stations in Suzhou's subway system (Lines 1 and 2). The real-time monitoring campaign was conducted from March 30(th) to April 10(th) and August 4(th) to August 21(st), 2015. The monitoring practice was carried out during rush (7:00-9:00 AM and 17:00-19:00 PM) and regular hours (other times) at the ground and underground levels under different weather conditions with a purpose of obtaining representative data...
March 24, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28337622/harnessing-fertilizer-potential-of-human-urine-in-a-mesocosm-system-a-novel-test-case-for-linking-the-loop-between-sanitation-and-aquaculture
#18
Sukanta Rana, Jayanta Kumar Biswas, Jörg Rinklebe, Erik Meers, Nanthi Bolan
Human urine (HU) is a biogenic fertilizer which has raised immense interest owing to its capacity of combining sanitation and nutrient recovery. In search of an alternative organic fertilizer for fish culture, the nutrient potential of HU was evaluated. Fries of Indian carps and larvae of freshwater prawn were reared for 120 days under six conditions: (a) aerated and (b) non-aerated fresh HU (0.01%), (c) cattle manure (CM; 1.8 kg tank(-1)), mixed treatment with CM and HU under (d) iso-phosphorus and (e) iso-nitrogenous condition and (f) control...
March 23, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28337565/blood-trace-metals-in-a-sporadic-amyotrophic-lateral-sclerosis-geographical-cluster
#19
Stefano De Benedetti, Giorgio Lucchini, Cristian Del Bò, Valeria Deon, Alessandro Marocchi, Silvana Penco, Christian Lunetta, Elisabetta Gianazza, Francesco Bonomi, Stefania Iametti
Amyotrophic lateral sclerosis (ALS) is a fatal disorder with unknown etiology, in which genetic and environmental factors interplay to determine the onset and the course of the disease. Exposure to toxic metals has been proposed to be involved in the etiology of the disease either through a direct damage or by promoting oxidative stress. In this study we evaluated the concentration of a panel of metals in serum and whole blood of a small group of sporadic patients, all living in a defined geographical area, for which acid mine drainage has been reported...
March 23, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28337329/antiparasitic-lead-discovery-toward-optimization-of-a-chemotype-with-activity-against-multiple-protozoan-parasites
#20
William Devine, Sarah M Thomas, Jessey Erath, Kelly A Bachovchin, Patricia J Lee, Susan E Leed, Ana Rodriguez, Richard J Sciotti, Kojo Mensa-Wilmot, Michael P Pollastri
Human African trypanosomiasis (HAT), Chagas disease, and leishmaniasis present a significant burden across the developing world. Existing therapeutics for these protozoal neglected tropical diseases suffer from severe side effects and toxicity. Previously, NEU-1045 (3) was identified as a promising lead with cross-pathogen activity, though it possessed poor physicochemical properties. We have designed a library of analogues with improved calculated physicochemical properties built on the quinoline scaffold of 3 incorporating small, polar aminoheterocycles in place of the 4-(3-fluorobenzyloxy)aniline substituent...
March 9, 2017: ACS Medicinal Chemistry Letters
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