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https://www.readbyqxmd.com/read/29342177/a-new-fluorescent-dye-accumulation-assay-for-parallel-measurements-of-the-abcg2-abcb1-and-abcc1-multidrug-transporter-functions
#1
Edit Szabó, Dóra Türk, Ágnes Telbisz, Nóra Kucsma, Tamás Horváth, Gergely Szakács, László Homolya, Balázs Sarkadi, György Várady
ABC multidrug transporters are key players in cancer multidrug resistance and in general xenobiotic elimination, thus their functional assays provide important tools for research and diagnostic applications. In this study we have examined the potential interactions of three key human ABC multidrug transporters with PhenGreen diacetate (PGD), a cell permeable fluorescent metal ion indicator. The non-fluorescent, hydrophobic PGD rapidly enters the cells and, after cleavage by cellular esterases, in the absence of quenching metal ions, PhenGreen (PG) becomes highly fluorescent...
2018: PloS One
https://www.readbyqxmd.com/read/29342150/in-vivo-osteoconductivity-of-surface-modified-ti-29nb-13ta-4-6zr-alloy-with-low-dissolution-of-toxic-trace-elements
#2
Eri Takematsu, Kimihiro Noguchi, Kensuke Kuroda, Toshiyuki Ikoma, Mitsuo Niinomi, Nobuhiro Matsushita
Simulated Body Fluid (SBF) has served as a useful standard to check the bioactivity of implant materials for years. However, it is not perfectly able to imitate human serum; sometimes disparities between the SBF test and animal test were confirmed. Therefore, to ensure the reliability of the results of the SBF test obtained from our previous study, an animal study was performed to check osteoconductivity of surface modified implant materials. Three types of solution processes, hydrothermal (H), electrochemical (E), and hydrothermal-electrochemical (HE), were performed on the Ti-29Nb-13Ta-4...
2018: PloS One
https://www.readbyqxmd.com/read/29340859/comparative-proteomics-of-chromium-transformed-beas-2b-cells-by-2d-dige-and-maldi-tof-tof-ms
#3
Jian Lu, Miaomiao Tang, Yi Liu, Jin Wang, Zhanao Wu
Chromium (Cr) is a highly toxic, common heavy metal used in industrial production. There are two types of Cr in nature: hexavalent chromium (Cr(VI)) and chromium trichloride (Cr(III)). Cr(III) is involved in the metabolism of sugars and lipids, whereas Cr(VI) is absorbed through the respiratory tract and skin and generates free radicals that result in secondary toxicity. Cr(VI) leads to cancer in the occupational population and is therefore recognized as a human carcinogen by the International Agency for Research on Cancer...
January 16, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29339275/biochar-based-functional-materials-in-the-purification-of-agricultural-wastewater-fabrication-application-and-future-research-needs
#4
REVIEW
Dongning Wei, Bingyu Li, Hongli Huang, Lin Luo, Jiachao Zhang, Yuan Yang, Jiajun Guo, Lin Tang, Guangming Zeng, Yaoyu Zhou
Nowadays, agricultural contamination is becoming more and more serious due to the rapid growth of agricultural industry, which discharged antibiotics, pesticides or toxic metals into farmlands. A large number of researchers have applied biochar-based functional materials to the treatment of agricultural wastewater contamination. Meanwhile, biochar has also proved to be a very promising and effective technology in water purification field due to its various beneficial properties (e.g., cost effective, high specific surface area, and surface reactive groups)...
January 2, 2018: Chemosphere
https://www.readbyqxmd.com/read/29339190/systemic-and-local-toxicity-of-metal-particles-released-from-hip-prostheses-a-review-of-experimental-approaches
#5
REVIEW
Divya Rani Bijukumar, Abhijith Segu, Júlio Cesar Matias de Souza, XueJun Li, Mark Barba, Louis Mercuri, Joshua Jacobs, Mathew Thoppil Mathew
Despite the technological improvements in orthopedic joint replacement implants, wear and corrosion products associated with the metal components of these implants may result in adverse local tissue and perhaps systemic reactions and toxicities. The current review encompasses a literature review of the local and systemic toxicity studies concerning the effect of CoCrMo wear particles released from wear and corrosion of orthopedic implants and prostheses. Release of metallic debris is mainly in the form of micro- and nano-particles, ions of different valences, and oxides composed of Co and Cr...
January 12, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29338896/novel-bioabsorbable-polymer-and-polymer-free-metallic-drug-eluting-stents
#6
REVIEW
Jason Nogic, Liam M McCormick, Rohin Francis, Nitesh Nerlekar, Catherine Jaworski, Nick E J West, Adam J Brown
The introduction of drug-eluting stents (DES) significantly reduced angiographic restenosis and the clinical need for revascularization following percutaneous coronary intervention. However, concerns remain regarding the long-term safety and efficacy of DES. The use of durable polymers for drug elution that have limited biocompatibility is thought to contribute toward DES failure, by promoting an adverse local inflammatory response and vascular toxicity. Biodegradable polymer and polymer-free metallic stents represent two novel technological solutions to this challenging clinical problem...
January 12, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29338696/transcriptional-responses-of-escherichia-coli-during-recovery-from-inorganic-or-organic-mercury-exposure
#7
Stephen P LaVoie, Anne O Summers
BACKGROUND: The protean chemical properties of mercury have long made it attractive for diverse applications, but its toxicity requires great care in its use, disposal, and recycling. Mercury occurs in multiple chemical forms, and the molecular basis for the distinct toxicity of its various forms is only partly understood. Global transcriptomics applied over time can reveal how a cell recognizes a toxicant and what cellular subsystems it marshals to repair and recover from the damage...
January 16, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29338175/limitations-of-cs3bi2i9-as-lead-free-photovoltaic-absorber-materials
#8
Biplab Ghosh, Bo Wu, Hemant Kumar Mulmudi, Claude Guet, Klaus Weber, Tze Chien Sum, Subodh G Mhaisalkar, Nripan Mathews
Lead (Pb) halide perovskites have attracted tremendous attention in recent years due to their rich optoelectronic properties, which have resulted in more than 22% power conversion efficient photovoltaics. Nevertheless, Pb-metal toxicity remains a huge hurdle for extensive applications of these compounds. Thus, alternative compounds with similar optoelectronic properties need to be developed. Bismuth possesses similar electronic structure as that of lead with the presence of ns2 electrons that exhibit rich structural variety as well as interesting optical and electronic properties...
January 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29337587/use-of-lactic-acid-bacteria-and-yeasts-to-reduce-exposure-to-chemical-food-contaminants-and-toxicity
#9
Gabriela Matuoka Chiocchetti, Carlos Jadán-Piedra, Vicente Monedero, Manuel Zúñiga, Dinoraz Vélez, Vicenta Devesa
Chemical contaminants that are present in food pose a health problem and their levels are controlled by national and international food safety organizations. Despite increasing regulation, foods that exceed legal limits reach the market. In Europe, the number of notifications of chemical contamination due to pesticide residues, mycotoxins and metals is particularly high. Moreover, in many parts of the world, drinking water contains high levels of chemical contaminants owing to geogenic or anthropogenic causes...
January 16, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29336720/a-novel-4-phenyl-amino-thiourea-derivative-designed-for-real-time-ratiometric-colorimetric-detection-of-toxic-pb2
#10
Yi S Guang, Xia Ren, Shuang Zhao, Quan Z Yan, Gang Zhao, Yao H Xu
The objective of this study was to develop a ratiometric and colorimetric organic sensor for Pb2+ detection in environmental samples. A new probe 4-phenyl amino thiourea (PAT) was designed and synthesized using hydrazine hydrate and phenyl isothiocyanate as raw materials. After its structure was characterized and confirmed, its UV-vis spectral property was investigated in detail. PAT possesses a specifically real-time, ratiometric and colorimetric response to Pb2+ in dimethyl formamide (DMF)/H2O (v/v = 9:1, pH = 7...
January 16, 2018: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/29335513/optimal-ranges-of-variables-for-an-effective-adsorption-of-lead-ii-by-the-agricultural-waste-pomelo-citrus-grandis-peels-using-doehlert-designs
#11
Xiao-Lan Yu, Yong He
The capacity of pomelo peels' adsorption on lead(II) from aqueous solutions without modifications was investigated and confirmed. Four variables in this study, pH, temperature, time and initial concentration of lead(II), significantly affected the adsorption rate of pomelo peels. The prediction model and optimal ranges of optimized variables were given by Doehlert designs, which made the selection of variables rapid, flexible and effortless to obtain an adsorption rate reaching 99.9% and 20 mg/L for initial lead(II) concentration, 3 for pH, 50 °C for temperature and 210 min for time was a choice...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335462/iron-related-toxicity-of-single-walled-carbon-nanotubes-and-crocidolite-fibres-in-human-mesothelial-cells-investigated-by-synchrotron-xrf-microscopy
#12
Francesca Cammisuli, Silvia Giordani, Alessandra Gianoncelli, Clara Rizzardi, Lucia Radillo, Marina Zweyer, Tatiana Da Ros, Murielle Salomé, Mauro Melato, Lorella Pascolo
Carbon nanotubes (CNTs) are promising products in industry and medicine, but there are several human health concerns since their fibrous structure resembles asbestos. The presence of transition metals, mainly iron, in the fibres seems also implicated in the pathogenetic mechanisms. To unravel the role of iron at mesothelial level, we compared the chemical changes induced in MeT-5A cells by the exposure to asbestos (crocidolite) or CNTs at different content of iron impurities (raw-SWCNTs, purified- and highly purified-SWCNTs)...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335221/highly-efficient-solar-driven-photocatalytic-degradation-on-environmental-pollutants-over-a-novel-c-fibers-mose2-nanoplates-core-shell-composite
#13
Meng Wang, Zhijian Peng, Jingwen Qian, Hong Li, Zengying Zhao, Xiuli Fu
As an important member of two-dimensional transition metal dichalcogenides, MoSe2 has a wide range of photoelectrochemical properties. However, MoSe2 alone can not directly be used as photocatalyst for its poor performance owing to the strong recombination of photogenerated electron-hole pairs. Here, we propose a novel C fibers@MoSe2 nanoplates core-shell composite, which was prepared by a facile, one-step thermal evaporation method. The composite has a remarkable feature of numerous MoSe2 thin nanoplates grown in-situ, densely and even vertically on the surface of the C fibers...
January 10, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29335173/application-of-fe3o4-mil-100-fe-core-shell-magnetic-microspheres-for-evaluating-the-sorption-of-organophosphate-esters-to-dissolved-organic-matter-dom
#14
Long Pang, Peijie Yang, Huiqiang Yang, Liming Ge, Jingwen Xiao, Yifan Zhou
Organophosphate esters (OPEs) are widely used as flame retardants and plasticizers in many products and materials. Because of the potential biologic toxicity on human beings, OPEs are regarded as a class of emerging pollutants. Dissolved organic matters (DOM) have significant effects on the bioavailability and toxicity of the pollutants in the environment. Negligible-depletion solid-phase microextraction (nd-SPME) is an efficient way for measuring the freely dissolved pollutants but suffers from long equilibrium time...
January 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29335169/seasonal-variations-in-fine-particle-composition-from-beijing-prompt-oxidative-stress-response-in-mouse-lung-and-liver
#15
Michal Pardo, Fanfan Xu, Xinghua Qiu, Tong Zhu, Yinon Rudich
Exposure to air pollution can induce oxidative stress, inflammation and adverse health effects. To understand how seasonal and chemical variations drive health impacts, we investigated indications for oxidative stress and inflammation in mice exposed to water and organic extracts from urban fine particles/PM2.5 (particles with aerodynamic diameter ≤ 2.5 μm) collected in Beijing, China. Higher levels of pollution components were detected in heating season (HS, winter and part of spring) PM2.5 than in the non-heating season (NHS, summer and part of spring and autumn) PM2...
January 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29334672/oxidative-and-interactive-challenge-of-cadmium-and-ocean-acidification-on-the-smooth-scallop-flexopecten-glaber
#16
Alessandro Nardi, Maura Benedetti, Daniele Fattorini, Francesco Regoli
Ocean acidification (OA) may affect sensitivity of marine organisms to metal pollution modulating chemical bioavailability, bioaccumulation and biological responsiveness of several cellular pathways. In this study, the smooth scallop Flexopecten glaber was exposed to various combinations of reduced pH (pH/pCO2 7.4/∼3000 μatm) and Cd (20 μg/L). The analyses on cadmium uptake were integrated with those of a wide battery of biomarkers including metallothioneins, single antioxidant defenses and total oxyradical scavenging capacity in digestive gland and gills, lysosomal membrane stability and onset of genotoxic damage in haemocytes...
January 8, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29334159/a-gold-iii-pincer-ligand-scaffold-for-the-synthesis-of-binuclear-and-bioconjugated-complexes-synthesis-and-anticancer-potential
#17
Bertrand Benoît, Maria A O'Connell, Zöe A E Waller, Manfred Bochmann
Cyclometalated (C^N^C)Au(III) complexes bearing functionalized N-heterocyclic carbene (NHC) ligands provide a high-yielding, modular route to bioconjugated and binuclear complexes. That methodology has been applied to the synthesis of bioconjugated complexes presenting biotin and 17α-ethynylestradiol vectors, as well as to the synthesis of bimetallic Au(III)/Au(I) complexes. The in vitro antiproliferative activities of these compounds against various cancer cells lines depend on the linker length, with the longer linker being the most potent...
January 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29334095/gd3-doped-mose2-nanosheets-used-as-a-theranostic-agent-for-bimodal-imaging-and-highly-efficient-photothermal-cancer-therapy
#18
Jiali Pan, Xufeng Zhu, Xu Chen, Yingyu Zhao, Jie Liu
Recently, two dimensional transition metal dichalcogenides (TMDCs) being used as nanomedicine have aroused great interest because of their unique photothermal properties. A simple liquid-phase method was used to prepare gadolinium (Gd3+)-doped molybdenum selenide (MoSe2) nanosheets, and then using poly(ethylene glycol) (PEG) modification on the surface, MoSe2(Gd3+)-PEG nanosheets were obtained which had high stability in physiological solutions and showed no obvious toxicity in vivo. It revealed that Gd3+ used as a paramagnetic material for MoSe2(Gd3+)-PEG provided a strong contrast effect in magnetic resonance imaging, furthermore, the MoSe2 showed strong absorption in the near infrared region, and therefore, MoSe2(Gd3+)-PEG could be used as contrast agent for photoacoustic imaging (PAI)...
January 15, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29333807/contribution-of-diet-to-lead-exposure-among-children-aged-1-to-7-years-in-la-plata-buenos-aires
#19
Enrique Martins, Agustina Malpeli, Daniel Asens, Luis Telese, Victoria Fasano, Vania Vargas, Marina Tavella, Jorge E Colman Lerner
INTRODUCTION: Lead is a toxic metal which, even at low blood levels, can alter normal neurodevelopment in children, so no blood lead level is acceptable. Lead absorption from diet accounts for the highest contribution to blood lead levels in the population who is not exposed to contaminated environments or because of their occupation. The objective of this study was to determine the contribution of diet to lead exposure among children aged 1 to 7 years who attended Hospital de Niños de La Plata for health check-ups...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29333545/dynamic-changes-in-copper-homeostasis-and-post-transcriptional-regulation-of-atp7a-during-myogenic-differentiation
#20
Katherine E Vest, Amanda L Paskavitz, Joseph B Lee, Teresita Padilla-Benavides
Copper (Cu) is an essential metal required for activity of a number of redox active enzymes that participate in critical cellular pathways such as metabolism and cell signaling. Because it is also a toxic metal, Cu must be tightly controlled by a series of transporters and chaperone proteins that regulate Cu homeostasis. The critical nature of Cu is highlighted by the fact that mutations in Cu homeostasis genes cause pathologic conditions such as Menkes and Wilson diseases. While Cu homeostasis in highly affected tissues like the liver and brain is well understood, no study has probed the role of Cu in development of skeletal muscle, another tissue that often shows pathology in these conditions...
January 15, 2018: Metallomics: Integrated Biometal Science
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