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https://www.readbyqxmd.com/read/28738631/a-review-aptamer-based-analytical-strategies-using-the-nanomaterials-for-environmental-and-human-monitoring-of-toxic-heavy-metals
#1
REVIEW
Leila Farzin, Mojtaba Shamsipur, Shahab Sheibani
Recent developments in biotechnology offer the new methods for the sensitive detection of heavy metals based on the affinity and specificity of aptamers, as nucleic acid ligands selected from random sequence pools in vitro. Heavy metals have received considerable importance as the most toxic metallic pollutants which may cause serious environmental damages. They are classified as trace elements because of their presence in trace concentrations in various environmental matrices. Thus, the precise and sensitive methods to detect heavy metals are important to ensure human and environment safety...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738577/high-bright-fluorescent-carbon-dot-as-versatile-sensing-platform
#2
Mumei Han, Liping Wang, Siheng Li, Liang Bai, Yunjie Zhou, Yue Sun, Hui Huang, Hao Li, Yang Liu, Zhenhui Kang
The surface functionalization will introduce additional functional groups on carbon dots (CDs) surface and then enrich the properties of CDs. Here, we show the various surface functionalized CDs (-COOH, -OH, -SH, -NH2, etc, named as NS-CDs) were synthesized with fascinating features, including high quantum efficiency (38.9%), long-term stability and good biocompatibility. Notably, it can serve as multifunction fluorescent probe in sensing system, including label-free detections in hydrogen peroxide (H2O2) with a wide linear range (1...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28737720/a-simple-and-highly-sensitive-thymine-sensor-for-mercury-ion-detection-based-on-surface-enhanced-raman-spectroscopy-and-the-mechanism-study
#3
Hao Yang, Sui-Bo Ye, Yu Fu, Weihong Zhang, Fangyan Xie, Li Gong, Ping-Ping Fang, Jian Chen, Yexiang Tong
Mercury ion (Hg(2+)) is recognized as one of the most toxic metal ions for the environment and for human health. Techniques utilized in the detection of Hg(2+) are an important factor. Herein, a simple thymine was successfully employed as the surface enhanced Raman spectroscopy sensor for Hg(2+) ion detection. The limit of detection (LOD) of the developed sensor is better than 0.1 nM (0.02 ppb). This sensor can also selectively distinguish Hg(2+) ions over 7 types of alkali, heavy metal and transition-metal ions...
July 24, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28737682/cadmium-handling-toxicity-and-molecular-targets-involved-during-pregnancy-lessons-from-experimental-models
#4
REVIEW
Tania Jacobo-Estrada, Mitzi Santoyo-Sánchez, Frank Thévenod, Olivier Barbier
Even decades after the discovery of Cadmium (Cd) toxicity, research on this heavy metal is still a hot topic in scientific literature: as we wrote this review, more than 1440 scientific articles had been published and listed by the PubMed.gov website during 2017. Cadmium is one of the most common and harmful heavy metals present in our environment. Since pregnancy is a very particular physiological condition that could impact and modify essential pathways involved in the handling of Cd, the prenatal life is a critical stage for exposure to this non-essential element...
July 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28737385/a-synthetic-circuit-for-mercury-bioremediation-using-self-assembling-functional-amyloids
#5
Pei Kun Richie Tay, Peter Q Nguyen, Neel S Joshi
Synthetic biology approaches to bioremediation are a key sustainable strategy to leverage the self-replicating and programmable aspects of biology for environmental stewardship. The increasing spread of anthropogenic mercury pollution into our habitats and food chains is a pressing concern. Here, we explore the use of programmed bacterial biofilms to aid in the sequestration of mercury. We demonstrate that by integrating a mercury-responsive promoter and an operon encoding a mercury-absorbing self-assembling extracellular protein nanofiber, we can engineer bacteria that can detect and sequester toxic Hg2+ ions from the environment...
July 24, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28736190/molecular-dynamics-simulations-of-zinc-oxide-solubility-from-bulk-down-to-nanoparticles
#6
Laura Escorihuela, Alberto Fernández, Robert Rallo, Benjamí Martorell
The solubility of metal oxides is one of the key descriptors for the evaluation of their potential toxic effects, both in the bulk form and in nanoparticulated aggregates. Current work presents a new methodology for the in silico assessment of the solubility of metal oxides, which is demonstrated using a well-studied system, ZnO. The calculation of the solubility is based on statistical thermodynamics tools combined with Density Functional Tight Binding theory for the evaluation of the free energy exchange during the dissolution process...
July 20, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28735183/reductive-dechlorination-of-trichloroethylene-by-polyvinylpyrrolidone-stabilized-nanoscale-zerovalent-iron-particles-with-ni
#7
Macharla Arun Kumar, Sungjun Bae, Seunghee Han, Yoonseok Chang, Woojin Lee
We developed a novel stabilized nanoscale zerovalent iron (NZVI) particles with Ni using an electron conducting polymer, polyvinylpyrrolidone (PVP), to selectively dechlorinate trichloroethylene (TCE) to non-toxic intermediates. The size of the PVP stabilized NZVI-Ni ((PVP-NZVI-Ni), average diameter: ∼20nm) is smaller than that of bare NZVI (50-80nm) due to the prevention of agglomeration of the resultant iron particles by PVP. PVP-NZVI-Ni showed a complete removal of TCE in 1h with superior dechlorination kinetics (kobs=5...
July 14, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28735175/cancer-cell-membrane-coated-biomimetic-platform-for-tumor-targeted-photodynamic-therapy-and-hypoxia-amplified-bioreductive-therapy
#8
Shi-Ying Li, Hong Cheng, Wen-Xiu Qiu, Lu Zhang, Shuang-Shuang Wan, Jing-Yue Zeng, Xian-Zheng Zhang
Modulating tumor microenvironment to amplify the therapeutic efficiency would be a novel strategy for effective cancer treatment. In this work, based on the TPZ-loaded porphyrinic metal organic framework PCN-224 (PCN stands for porous coordination network), a cancer cell membrane-coated nanoplatform (TPZ@PCN@Mem) was fabricated for tumor targeted PDT and the successively resulting hypoxia-amplified bioreductive therapy. After administration, TPZ@PCN@Mem exhibited the selective accumulation and long-term retention at tumor tissue due to the immune escape and homologous targeting endowed by the cancer membrane coating...
July 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28735157/effects-of-adhesions-of-amorphous-fe-and-al-hydroxides-on-surface-charge-and-adsorption-of-k-and-cd-2-on-rice-roots
#9
Zhao-Dong Liu, Hai-Cui Wang, Qin Zhou, Ren-Kou Xu
Iron (Fe) and aluminum (Al) hydroxides in variable charge soils attached to rice roots may affect surface-charge properties and subsequently the adsorption and uptake of nutrients and toxic metals by the roots. Adhesion of amorphous Fe and Al hydroxides onto rice roots and their effects on zeta potential of roots and adsorption of potassium (K(+)) and cadmium (Cd(2+)) by roots were investigated. Rice roots adsorbed more Al hydroxide than Fe hydroxide because of the greater positive charge on Al hydroxide. Adhesion of Fe and Al hydroxides decreased the negative charge on rice roots, and a greater effect of the Al hydroxide...
July 20, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28733784/environmental-impact-of-coal-mining-and-coal-seam-gas-production-on-surface-water-quality-in-the-sydney-basin-australia
#10
A Ali, V Strezov, P Davies, I Wright
The extraction of coal and coal seam gas (CSG) will generate produced water that, if not adequately treated, will pollute surface and groundwater systems. In Australia, the discharge of produced water from coal mining and related activities is regulated by the state environment agency through a pollution licence. This licence sets the discharge limits for a range of analytes to protect the environment into which the produced water is discharged. This study reports on the impact of produced water from coal mine activities located within or discharging into high conservation environments, such as National Parks, in the outer region of Sydney, Australia...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28732404/influence-of-the-stabilizers-on-the-toxicity-of-metallic-nanomaterials-in-aquatic-organisms-and-human-cell-lines
#11
Tatiana Andreani, Verónica Nogueira, Vera V Pinto, Maria José Ferreira, Maria Graça Rasteiro, Amélia M Silva, Ruth Pereira, Carlos M Pereira
In this study, following a systematic approach, we used aquatic species (bacteria Vibrio fischeri and microalgae Raphidocelis subcapitata) and different human cell lines (Caco-2, HepG2, SV-80 and HaCaT) representing different tissues and exposure pathways, to investigate how two organic stabilizers (PVA and DMSO) used for NMs dispersion influence their physicochemical properties, the persistence of metals in suspension and the toxicity/ecotoxicity of two metallic NMs (nano-Ag and nano-Cu). Although the stabilizers are expected to contribute to improve the dispersion and stability of NMs, the results obtained clearly showed that no similar changes in toxicity and morphological properties of the nano-Ag can be expected after its stabilization with PVA...
July 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28732062/a-drosophila-model-for-toxicogenomics-genetic-variation-in-susceptibility-to-heavy-metal-exposure
#12
Shanshan Zhou, Sarah E Luoma, Genevieve E St Armour, Esha Thakkar, Trudy F C Mackay, Robert R H Anholt
The genetic factors that give rise to variation in susceptibility to environmental toxins remain largely unexplored. Studies on genetic variation in susceptibility to environmental toxins are challenging in human populations, due to the variety of clinical symptoms and difficulty in determining which symptoms causally result from toxic exposure; uncontrolled environments, often with exposure to multiple toxicants; and difficulty in relating phenotypic effect size to toxic dose, especially when symptoms become manifest with a substantial time lag...
July 21, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28731309/toxicology-of-lead-and-its-damage-to-mammalian-organs
#13
Samuel Caito, Ana Carolina B Almeida Lopes, Monica M B Paoliello, Michael Aschner
The toxicity of lead has been appreciated for centuries. Lead is a commonly used metal in industrialized nations, which results in the release of lead into the environment. Governmental agencies regulate the amount of lead permissible for workers to be exposed to; however, unregulated environmental lead exposure is a high concern. While essential metals have physiologic roles, there are no health benefits from lead intake. In this chapter, we discuss sources of lead exposure, the absorption, distribution, and elimination of lead from the human body, and molecular mechanisms of lead-induced toxicity...
April 10, 2017: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/28731308/lead-toxicity-in-plants
#14
Hendrik Küpper
This review looks critically at the relevance of lead (Pb2+) toxicity and proposed mechanisms of Pb2+ -induced stress in algae and higher plants. As a basis, the current main sources of Pb2+ contamination in the environment are presented, which include agriculture, industry, and road traffic. Further, bioavailability of lead is discussed as a basis for evaluating the environmental relevance of the many studies on lead toxicity that have been published in the past decades. These studies suggest three main mechanisms of toxicity of Pb2+: inhibition of photosynthesis, oxidative stress, and "genotoxicity" including DNA damage and defects in mitosis...
April 10, 2017: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/28731305/the-role-of-lead-ii-in-nucleic-acids
#15
Joana Palou-Mir, Miquel Barceló-Oliver, Roland K O Sigel
Although lead(II) is naturally not associated with nucleic acids, this metal ions has been applied with DNA and RNA in various contexts. Pb2+ is an excellent hydrolytic metal ion for nucleic acids, which is why it is mainly used as probing agent for secondary structure and to determine metal ion binding sites both in vitro and in vivo. A further application of lead(II) is in structural studies, i.e., NMR, but also in X-ray crystallography, mostly using this heavy metal to solve the phase problem in the latter method...
April 10, 2017: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/28731304/complex-formation-of-lead-ii-with-nucleotides-and-their-constituents
#16
Astrid Sigel, Bert P Operschall, Helmut Sigel
Lead is widely distributed in the environment; it is known to mankind for thousands of years and its toxicity is nowadays (again) well recognized, though on the molecular level only partly understood. One of the reasons for this shortcoming is that the coordination chemistry of the biologically important lead(II) is complicated due to the various coordination numbers it can adopt (CN = 4 to 10) as well as by the 6s2 electron lone pair which, with CN = 4, can shield one side of the Pb2+ coordination sphere. The chapter focuses on the properties of Pb2+ complexes formed with nucleotides and their constituents and derivatives...
April 10, 2017: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/28731302/lead-ii-binding-in-metallothioneins
#17
Daisy L Wong, Maureen E Merrifield-MacRae, Martin J Stillman
Heavy metal exposure has long been associated with metallothionein (MT) regulation and its functions. MT is a ubiquitous, cysteine-rich protein that is involved in homeostatic metal response for the essential metals zinc and copper, as well as detoxification of heavy metals; the most commonly proposed being cadmium. MT binds in vivo to a number of metals in addition to zinc, cadmium and copper, such as bismuth. In vitro, metallation with a wide range of metals (especially mercury, arsenic, and lead) has been reported using a variety of analytical methods...
April 10, 2017: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/28731297/smart-capsules-for-lead-removal-from-industrial-wastewater
#18
Bartosz Tylkowski, Renata Jastrząb
Ground and especially drinking water could be contaminated by heavy metal ions such as lead and chromium, or the metalloid arsenic, discarded from industrial wastewater. These heavy metal ions are regarded as highly toxic pollutants which could cause a wide range of health problems in case of a long-term accumulation in the body. Thus, there have been many efforts to reduce the concentration of lead ions in effluent wastewater. They have included the establishment of stringent permissible discharge levels and management policies, the application of various pollution-control technologies, and the development of adsorbent materials for lead reduction...
April 10, 2017: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/28731295/biogeochemistry-of-lead-its-release-to-the-environment-and-chemical-speciation
#19
Jay T Cullen, Jason McAlister
Lead (Pb) is a metal that is not essential for life processes and proves acutely toxic to most organisms. Compared to other metals Pb is rather immobile in the environment but still its biogeochemical cycling is greatly perturbed by human activities. In this review we present a summary of information describing the physical and chemical properties of Pb, its distribution in crustal materials, and the processes, both natural and anthropogenic, that contribute to the metal's mobilization in the biosphere. The relatively high volatility of Pb metal, low melting point, its large ionic radius, and its chemical speciation in aquatic systems contributes to its redistribution by anthropogenic and natural processes...
April 10, 2017: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/28730150/from-electrochemical-biosensors-to-biomimetic-sensors-based-on-molecularly-imprinted-polymers-in-environmental-determination-of-heavy-metals
#20
REVIEW
Cosimino Malitesta, Sabrina Di Masi, Elisabetta Mazzotta
Recent work relevant to heavy metal determination by inhibition-enzyme electrochemical biosensors and by selected biomimetic sensors based on molecularly imprinted polymers has been reviewed. General features and peculiar aspects have been evidenced. The replace of biological component by artificial receptors promises higher selectivity and stability, while biosensors keep their capability of producing an integrated response directly related to biological toxicity of the samples.
2017: Frontiers in Chemistry
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