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https://www.readbyqxmd.com/read/28538697/mammalian-metallothionein-3-new-functional-and-structural-insights
#1
REVIEW
Milan Vašák, Gabriele Meloni
Metallothionein-3 (MT-3), a member of the mammalian metallothionein (MT) family, is mainly expressed in the central nervous system (CNS). MT-3 possesses a unique neuronal growth inhibitory activity, and the levels of this intra- and extracellularly occurring metalloprotein are markedly diminished in the brain of patients affected by a number of metal-linked neurodegenerative disorders, including Alzheimer's disease (AD). In these pathologies, the redox cycling of copper, accompanied by the production of reactive oxygen species (ROS), plays a key role in the neuronal toxicity...
May 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28538683/metabolic-investigations-of-the-molecular-mechanisms-associated-with-parkinson-s-disease
#2
REVIEW
Robert Powers, Shulei Lei, Annadurai Anandhan, Darrell D Marshall, Bradley Worley, Ronald L Cerny, Eric D Dodds, Yuting Huang, Mihalis I Panayiotidis, Aglaia Pappa, Rodrigo Franco
Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar cytoplasmic aggregates of α-synuclein (i.e., Lewy bodies) and the associated loss of dopaminergic cells in the substantia nigra. Mutations in genes such as α-synuclein (SNCA) account for only 10% of PD occurrences. Exposure to environmental toxicants including pesticides and metals (e.g., paraquat (PQ) and manganese (Mn)) is also recognized as an important PD risk factor. Thus, aging, genetic alterations, and environmental factors all contribute to the etiology of PD...
May 24, 2017: Metabolites
https://www.readbyqxmd.com/read/28537817/the-action-of-probiotic-microorganisms-on-chemical-contaminants-in-milk
#3
Katia Francine Wochner, Tânia Aparecida Becker-Algeri, Eliane Colla, Eliana Badiale-Furlong, Deisy Alessandra Drunkler
Consumption of milk and its derivatives is an important food habit in the diet of all age groups. However, there has been increasing concern about physical, biological (pathogenic or spoilage microorganisms) and chemical (metals, pesticides and mycotoxins) contaminants in milk and dairy products. Considering the high levels of consumption, it is important that milk and dairy products are free from toxic compounds. Microbial degradation as a strategy for chemical decontamination is an emerging biotechnological approach that is considered a safe and inexpensive practice...
May 24, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28535068/a-conformal-lithium-fluoride-protection-layer-on-three-dimensional-lithium-by-non-hazardous-gaseous-reagent-freon
#4
Dingchang Lin, Yayuan Liu, Wei Chen, Guangmin Zhou, Kai Liu, Bruce S Dunn, Yi Cui
Research on lithium (Li) metal chemistry has been rapidly gaining momentum nowadays not only because of the appealing high theoretical capacity, but also its indispensable role in the next-generation Li-S and Li-air batteries. However, two root problems of Li metal, namely high reactivity and infinite relative volume change during cycling, bring about numerous other challenges that impede its practical applications. In the past, extensive studies have targeted these two root causes by either improving interfacial stability or constructing a stable host...
May 23, 2017: Nano Letters
https://www.readbyqxmd.com/read/28534627/highly-stable-and-regenerative-metal-organic-framework-designed-by-multi-walled-divider-installation-strategy-for-detection-of-co-%C3%AE-%C3%AE-ions-and-organic-aromatics-in-water
#5
Kai Xing, Ruiqing Fan, Jiaqi Wang, Siqi Zhang, Kai Feng, Xi Du, Yang Song, Ping Wang, Yulin Yang
MOF-based sensors capable of effectively and stably detecting toxic species in water have attracted huge attention in terms of improving environmental monitoring levels and water quality. Combining the flexibility of structure and modifying of pore surface, a multi-walled divider installation (MWDI) strategy is proposed and used for property enhancement. We herein report three metal-organic frameworks (MOFs) 1-3 based on a C3 symmetry organic phosphonic ligand with topology increased from 3,6-connected to 3,8-connected...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28532901/long-term-surveillance-of-zinc-implant-in-murine-artery-surprisingly-steady-biocorrosion-rate
#6
Adam Drelich, Shan Zhao, Roger J Guillory, Jaroslaw W Drelich, Jeremy Goldman
Metallic zinc implanted into the abdominal aorta of rats out to 6 months has been demonstrated to degrade while avoiding responses commonly associated with the restenosis of vascular implants. However, major questions remain regarding whether a zinc implant would ultimately passivate through the production of stable corrosion products or via a cell mediated fibrous encapsulation process that prevents the diffusion of critical reactants and products at the metal surface. Here, we have conducted clinically relevant long term in vivo studies in order to characterize late stage zinc implant biocorrosion behavior and products to address these critical questions...
May 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28532345/treatment-of-real-industrial-wastewaters-through-nano-tio2-and-nano-fe2o3-photocatalysis-case-study-of-mining-and-kraft-pulp-mill-effluents
#7
V Nogueira, I Lopes, T A P Rocha-Santos, F Gonçalves, R Pereira
Over the last few decades, high quantities of industrial wastewaters containing a wide range of organic and inorganic pollutants are being directly discharged into the environment, sometimes without proper treatment. Many of these contaminants have been described as causing significant effects on the environment, especially after cumulative discharges. In this scenario, nanotechnology has a tremendous potential, due to the unique properties of the new produced nanomaterials (NMs), such as surface area, adsorptivity and photocatalytic potential, which can improve the existing treatments or even develop new treatment solutions...
May 22, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28532048/surface-grafting-of-eu-3-doped-luminescent-hydroxyapatite-nanomaterials-through-metal-free-light-initiated-atom-transfer-radical-polymerization-for-theranostic-applications
#8
Guangjian Zeng, Meiying Liu, Ruming Jiang, Chunning Heng, Qiang Huang, Liucheng Mao, Junfeng Hui, Fengjie Deng, Xiaoyong Zhang, Yen Wei
We reported a simple and efficient method to prepare the hydrophilic luminescent HAp polymer nanocomposites through the combination of ligand exchange and metal free light initiated surface-initiated atom transfer radical polymerization (SI-ATRP) using 10-phenylphenothiazine (PTH) as organic catalyst and 2-methacryloyloxyethyl phosphorylcholine (MPC) and itaconic acid (IA) as monomers. The biological imaging and drug delivery performance of HAp-poly(MPC-IA) nanorods were examined to evaluate their potential for biomedical applications...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531948/an-alternative-approach-to-risk-rank-chemicals-on-the-threat-they-pose-to-the-aquatic-environment
#9
Andrew C Johnson, Rachel L Donnachie, John P Sumpter, Monika D Jürgens, Claudia Moeckel, M Gloria Pereira
This work presents a new and unbiased method of risk ranking chemicals based on the threat they pose to the aquatic environment. The study ranked 12 metals, 23 pesticides, 11 other persistent organic pollutants (POPs), 13 pharmaceuticals, 10 surfactants and similar compounds and 2 nanoparticles (total of 71) of concern against one another by comparing their median UK river water and median ecotoxicity effect concentrations. To complement this, by giving an assessment on potential wildlife impacts, risk ranking was also carried out by comparing the lowest 10th percentile of the effects data with the highest 90th percentile of the exposure data...
May 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28531947/shifts-in-the-relative-abundance-of-bacteria-after-wine-lees-derived-biochar-intervention-in-multi-metal-contaminated-paddy-soil
#10
Min Xu, Hongxia Xia, Jun Wu, Gang Yang, Xiaohong Zhang, Hong Peng, Xiaoyu Yu, Li Li, Hong Xiao, Hui Qi
The impact of biochar application on soil ecological functions depends on the diversity of soil conditions and of the feedstocks from which biochar is obtained. Moreover, little information is available on the effect of biochar on dynamic changes in microorganisms with the development of rice plants in multi-metal-contaminated paddy soil amended with wine-lees-derived biochar. In this paper, biochar obtained from the pyrolysis of wine lees at 600°C was used to investigate the potential role of biochar in maintaining soil ecological functions, with consideration of the alteration of the microbial population over periods of rice growth...
May 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28531761/3%C3%AE-hydroxy-urs-12-en-28-oic-acid-confers-protection-against-znonps-induced-adversity-in-caenorhabditis-elegans
#11
Hema Negi, Shilpi Khare Saikia, Ranjana Kanaujia, Satish Jaiswal, Rakesh Pandey
Despite their well reported potent risk towards human health and environment Zinc oxide nanoparticles (ZnONPs) find an extensive commercial usage due to their antimicrobial properties. Here, we evaluated the efficacy of a natural triterpene ursolic acid (3β-hydroxy-urs-12-en-28-oic acid; UA) for overcoming the cytotoxic challenges of ZnONPs employing Ceanorhabditis elegans. The 24h LC50 of Zn-ONPs (<50nm TEM) was deduced as 4.75mgL(-1). UA (25μM) was observed to defend against this toxicity by attenuating Reactive Oxygen Species (ROS) resulting into better survival at 2mgL(-1) in a time dependent behavior...
May 8, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28531658/co-plantation-of-aquatic-macrophytes-typha-angustifolia-and-paspalum-scrobiculatum-for-effective-treatment-of-textile-industry-effluent
#12
Vishal V Chandanshive, Niraj R Rane, Asif S Tamboli, Avinash R Gholave, Rahul V Khandare, Sanjay P Govindwar
Field treatment of textile industry effluent was carried out in constructed drenches (91.4m×1.2m×0.6m; 65.8m(3)) planted independently with Typha angustifolia, Paspalum scrobiculatum and their co-plantation (consortium-TP). The in situ treatment of effluent by T. angustifolia, P. scrobiculatum and consortium-TP was found to decrease ADMI color value by 62, 59 and 76%, COD by 65, 63 and 70%, BOD by 68, 63 and 75%, TDS by 45, 39 and 57%, and TSS by 35, 31 and 47%, respectively within 96h. Heavy metals such as arsenic, cadmium, chromium and lead were also removed up to 28-77% after phytoremediation...
May 12, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28531655/competitive-adsorption-behavior-toward-metal-ions-on-nano-fe-mg-ni-ternary-layered-double-hydroxide-proved-by-xps-evidence-of-selective-and-sensitive-detection-of-pb-ii
#13
Shan-Shan Li, Min Jiang, Tian-Jia Jiang, Jin-Huai Liu, Zheng Guo, Xing-Jiu Huang
Hypersensitive and highly selective nanomaterials for the measurement of heavy metal ions (HMIs) hold a key to electro-analysis. Various works improved the results of analysis but without scientific understanding. Herein, Fe/Mg/Ni-layered double hydroxide (LDH) has been successfully prepared and its electrochemical behavior for Pb(II) detection is also studied using square wave anodic stripping voltammetry (SWASV). The well performance of electrochemistry suggest that the modification with Fe/Mg/Ni-LDH significantly promotes the selectivity and sensitivity toward Pb(II)...
May 11, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28531178/zebrafish-exposure-to-environmentally-relevant-concentration-of-depleted-uranium-impairs-progeny-development-at-the-molecular-and-histological-levels
#14
Olivier Armant, Kewin Gombeau, Sophia Murat El Houdigui, Magali Floriani, Virginie Camilleri, Isabelle Cavalie, Christelle Adam-Guillermin
Uranium is an actinide naturally found in the environment. Anthropogenic activities lead to the release of increasing amounts of uranium and depleted uranium (DU) in the environment, posing potential risks to aquatic organisms due to radiological and chemical toxicity of this radionucleide. Although environmental contaminations with high levels of uranium have already been observed, chronic exposures of non-human species to levels close to the environmental quality standards remain scarcely characterized. The present study focused on the identification of the molecular pathways impacted by a chronic exposure of zebrafish to 20 μg/L of DU during 10 days...
2017: PloS One
https://www.readbyqxmd.com/read/28530537/aspergillus-fischeri-mediated-biosynthesis-of-gold-nanoparticles-and-their-beneficially-comparative-effect-on-normal-and-cancer-cell-lines
#15
Kangkana Banerjee, Ravishankar Rai Vittal
Background Along with the intensified use of metal nanoparticles, growing concern of their adverse outcome on human health has also expanded, indicating that this work is an integral part of nanobioscience study. Objective The aim of this study was to evaluate varied effect of biosynthesized gold nanoparticles (AuNPs) on normal and cancerous mammalian cells. Methods AuNP synthesized and characterized by different characterization methods, here are produced by specifically isolated Aspergillus species, which is hardly explored in precious scientific findings...
May 22, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28530303/a-highly-sensitive-fet-type-aptasensor-using-flower-like-mos2-nanospheres-for-real-time-detection-of-arsenic-iii
#16
Ji Hyun An, Jyongsik Jang
Arsenic (As) contamination in drinking water is problematic due to its threat to human health. Highly stable, sensitive and selective sensors are needed for As(iii), which is the most toxic of the various forms of arsenic. Herein, we describe the fabrication of field-effect transistor (FET)-type aptasensors for As(iii) detection that is based on carboxylic polypyrrole (CPPy)-coated flower-like MoS2 nanospheres (CFMNSs). Arsenic-binding aptamer-conjugated CFMNSs were integrated into a liquid-ion gated FET system, leading to extraordinary performance with a rapid response (on a time scale of less than 1 s)...
May 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28530283/composite-cd-mof-nanocrystals-containing-microspheres-for-sustained-drug-delivery
#17
Haiyan Li, Nana Lv, Xue Li, Botao Liu, Jing Feng, Xiaohong Ren, Tao Guo, Dawei Chen, J Fraser Stoddart, Ruxandra Gref, Jiwen Zhang
Metal-organic frameworks (MOFs), which are typically embedded in polymer matrices as composites, are emerging as a new class of carriers for sustained drug delivery. Most of the MOFs and the polymers used so far in these composites, however, are not pharmaceutically acceptable. In the investigation reported herein, composites of γ-cyclodextrin (γ-CD)-based MOFs (CD-MOFs) and polyacrylic acid (PAA) were prepared by a solid in oil-in-oil (s/o/o) emulsifying solvent evaporation method. A modified hydrothermal protocol has been established which produces efficiently at 50 °C in 6 h micron (5-10 μm) and nanometer (500-700 nm) diameter CD-MOF particles of uniform size with smooth surfaces and powder X-ray diffraction patterns that are identical with those reported in the literature...
May 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28529528/safety-evaluation-of-potential-toxic-metals-exposure-from-street-foods-consumed-in-mid-west-nigeria
#18
O C Ekhator, N A Udowelle, S Igbiri, R N Asomugha, Z N Igweze, O E Orisakwe
Objective. Street-vended foods offer numerous advantages to food security; nevertheless, the safety of street food should be considered. This study has investigated the level of potential toxic metal (Pb, Cd, Hg, Sb, Mn, and Al) contamination among street-vended foods in Benin City and Umunede. Methods. Twenty street food samples were purchased from vendors at bus stops. Metals were analyzed with atomic absorption spectrophotometry. The methods developed by the US EPA were employed to evaluate the potential health risk of toxic metals...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28528650/the-role-of-intermetal-competition-and-mis-metalation-in-metal-toxicity
#19
Anna Barwinska-Sendra, Kevin J Waldron
The metals manganese, iron, cobalt, nickel, copper and zinc are essential for almost all bacteria, but their precise metal requirements vary by species, by ecological niche and by growth condition. Bacteria thus must acquire each of these essential elements in sufficient quantity to satisfy their cellular demand, but in excess these same elements are toxic. Metal toxicity has been exploited by humanity for centuries, and by the mammalian immune system for far longer, yet the mechanisms by which these elements cause toxicity to bacteria are not fully understood...
2017: Advances in Microbial Physiology
https://www.readbyqxmd.com/read/28528646/metal-based-combinations-that-target-protein-synthesis-by-fungi
#20
Cindy Vallières, Simon V Avery
A wide range of fungicides (or antifungals) are used in agriculture and medicine, with activities against a spectrum of fungal pathogens. Unfortunately, the evolution of fungicide resistance has become a major issue. Therefore, there is an urgent need for new antifungal treatments. Certain metals have been used for decades as efficient fungicides in agriculture. However, concerns over metal toxicity have escalated over this time. Recent studies have revealed that metals like copper and chromate can impair functions required for the fidelity of protein synthesis in fungi...
2017: Advances in Microbial Physiology
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