keyword
https://read.qxmd.com/read/38519544/-best-view-ever-observatory-will-map-big-bang-s-afterglow-in-new-detail
#21
Davide Castelvecchi
No abstract text is available yet for this article.
March 22, 2024: Nature
https://read.qxmd.com/read/38519312/sarcopenia-with-decreased-total-psoas-muscle-area-in-children-with-high-risk-neuroblastoma
#22
JOURNAL ARTICLE
Min-Jung Bang, Sanghoon Lee, Ji Won Lee, Wontae Kim, Ki Woong Sung, Jeong-Meen Seo
BACKGROUND: We calculated psoas muscle area (PMA) z-scores in high-risk neuroblastoma patients undergoing treatment to examine the clinical significance of sarcopenia in this cohort. METHODS: We analyzed retrospective data from patients aged 0-18 who were diagnosed with abdominal neuroblastoma between 2005 and 2019 at Samsung Medical Center. Patients categorized as high-risk undergone induction chemotherapy, neuroblastoma excision, and tandem high-dose chemotherapy with autologous stem cell transplantation (HDCT/auto-SCT) were selected...
March 21, 2024: Asian Journal of Surgery
https://read.qxmd.com/read/38518931/effects-of-radiation-dose-and-dose-rate-on-alginate-and-the-use-of-radiation-degraded-alginate-for-peanut
#23
JOURNAL ARTICLE
Nguyen Van Binh, Hoang Dang Sang, Tran Bang Diep, Tran Xuan An, Hoang Phuong Thao, Tran Minh Quynh
Aqueous solutions of alginate (4 %) with or without hydrogen peroxide (0-2 % H2 O2 ) were irradiated under a gamma Co-60 source. The effect of dose rate on the radiation scission yield (Gs) of resulting irradiated alginate was determined. At the dose of 20 kGy, the G(s) value of irradiated alginate decreased with the increase dose rate, suggesting that the irradiation at a suitable dose rate could further improve the radiation chemical yield of degradation. For the alginate irradiated at the same dose rate, G(s) value increased with the increase of H2 O2 concentration...
March 20, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38517590/compounds-from-agathis-dammara-exert-hypoglycaemic-activity-by-enhancing-glucose-uptake-lignans-terpenes-and-others
#24
JOURNAL ARTICLE
Zhe-Wei Yu, Bang-Ping Cai, Su-Zhi Xie, Yi Zhang, Wen-Hui Wang, Shun-Zhi Liu, Yan-Lin Bin, Qi Chen, Mei-Juan Fang, Rong Qi, Ming-Yu Li, Ying-Kun Qiu
In this study, two new kaurane diterpenes (16, 17), together with 12 lignans (1-12), a triterpene (15), and two other compounds (13, 14) were isolated from the woods of Agathis dammara. The structure of the new compound was determined by HR ESIMS and 1D/2D NMR spectroscopy, and its absolute configuration was determined by electronic circular dichroism (ECD) exciton chirality method. Compounds 5, 11, 14 exhibit significant hypoglycaemic activity in zebrafish, and their mechanism of action is to enhance glucose uptake in zebrafish...
March 22, 2024: Natural Products and Bioprospecting
https://read.qxmd.com/read/38514707/association-of-hla-drb1-locus-with-treatment-response-to-abatacept-or-tnf-inhibitors-in-patients-with-seropositive-rheumatoid-arthritis
#25
JOURNAL ARTICLE
Soojin Cha, So-Young Bang, Young Bin Joo, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Tae-Hwan Kim, Jae-Bum Jun, Dae Hyun Yoo, Hye-Soon Lee, Sang-Cheol Bae
The strongest genetic risk factor for rheumatoid arthritis (RA) has been known as HLA-DRB1 based on amino acid positions 11, 71, and 74. This study analyzed the association between specific HLA-DRB1 locus and treatment response to abatacept or TNF inhibitors (TNFi) in patients with seropositive RA. A total of 374 Korean RA patients were treated with abatacept (n = 110) or TNFi (n = 264). Associations between HLA-DRB1 and treatment response after 6 months were analyzed using multivariable logistic regression...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38513724/an-f-o-f-1-atpase-motor-embedded-chromatophore-as-a-nanorobot-for-overcoming-biological-barriers-and-targeting-acidic-tumor-sites
#26
JOURNAL ARTICLE
Qingliang Yang, Xuhui Zhou, Bang Lou, Ning Zheng, Jiale Chen, Gensheng Yang
Despite the booming progress of anticancer nanomedicines in the past two decades, precise tumor-targetability and sufficient tumor-accumulation are less successful and still require further research. To tackle this challenge, herein we present a biomolecular motor (FO F1 -ATPase)-embedded chromatophore as nanorobot to efficiently overcome biological barriers, and thoroughly investigate its chemotactic motility, tumor-accumulation ability and endocytosis. Chromatophores embedded with FO F1 -ATPase motors were firstly extracted from Thermus thermophilus, then their properties were fully characterized...
March 19, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38513383/paclitaxel-therapeutic-drug-monitoring-international-association-of-therapeutic-drug-monitoring-and-clinical-toxicology-recommendations
#27
REVIEW
Daniel L Hertz, Markus Joerger, Yung-Jue Bang, Ron H Mathijssen, Caicun Zhou, Li Zhang, David Gandara, Michael Stahl, Bradley J Monk, Ulrich Jaehde, Jan H Beumer
Paclitaxel, one of the most frequently used anticancer drugs, is dosed by body surface area, which leads to substantial inter-individual variability in systemic drug exposure. We evaluated clinical evidence regarding the scientific rationale and clinical benefit of individualized paclitaxel dosing based on measured systemic concentrations, known as therapeutic drug monitoring (TDM). In retrospective studies, higher systemic exposure is associated with greater toxicity and efficacy of paclitaxel treatment across several disease types and dosing regimens...
March 19, 2024: European Journal of Cancer
https://read.qxmd.com/read/38511337/lead-associated-mortality-in-the-us-1999-2020-a-time-stratified-analysis-of-a-national-cohort
#28
JOURNAL ARTICLE
De-Wei An, Yu-Ling Yu, Azusa Hara, Dries S Martens, Wen-Yi Yang, Yi-Bang Cheng, Qi-Fang Huang, Kei Asayama, Katarzyna Stolarz-Skrzypek, Marek Rajzer, Peter Verhamme, Tim S Nawrot, Yan Li, Jan A Staessen
OBJECTIVES: We undertook time-stratified analyses of the National Health and Nutrition Examination Survey in the US to assess time trends (1999-2020) in the associations of blood lead (BL) with blood pressure, mortality, the BL-associated population attributable fraction (PAF). METHODS: Vital status of participants, 20-79 years old at enrolment, was ascertained via the National Death Index. Regressions, mediation analyses and PAF were multivariable adjusted and standardized to 2020 US Census data...
March 15, 2024: Journal of Hypertension
https://read.qxmd.com/read/38509698/the-epidemiological-characteristics-of-sleep-disordered-breathing-in-congestive-heart-failure-a-prospective-single-centre-study-in-southeast-asia
#29
JOURNAL ARTICLE
Albert Iruthiaraj Lourdesamy Anthony, Rosilawati Abdul Rani
BACKGROUND: The presence of sleep-disordered breathing (SDB) in congestive heart failure (CHF) is associated with poor prognosis and is underdiagnosed despite advances in CHF management. The prevalence of SDB in CHF remains understudied in South East Asia. METHODS: A prospective, observational single-centre study was conducted where 116 consecutive patients in a specialised heart failure clinic underwent level 1, attended polysomnography (PSG). RESULTS: The prevalence of SDB was 78% using the apnoea-hypopnea index (AHI), AHI ⩾ 5/h threshold, and 59% with the AHI ⩾ 15/h threshold...
March 20, 2024: Journal of the Royal College of Physicians of Edinburgh
https://read.qxmd.com/read/38509504/transgelin-2-a-novel-cancer-stem-cell-related-biomarker-is-a-diagnostic-and-therapeutic-target-for-biliary-tract-cancer
#30
JOURNAL ARTICLE
Jung Hyun Jo, Soo Been Park, Joowon Chung, Taeyun Oh, Hee Seung Lee, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Dawoon E Jung, Si Young Song
BACKGROUND: Biliary tract cancer (BTC) is a relatively rare but aggressive gastrointestinal cancer with a high mortality rate. Cancer stem cell (CSC) populations play crucial roles in tumor biology and are responsible for the low response to anti-cancer treatment and the high recurrence rate. This study investigated the role of Transgelin-2 (TAGLN2), overexpressed in CSC in BTC cells, and analyzed its expression in patient tissues and serum to identify potential new targets for BTC. METHODS: TAGLN2 expression was suppressed by small-interfering or short hairpin RNAs, and its effects on tumor biology were assessed in several BTC cell lines...
March 20, 2024: BMC Cancer
https://read.qxmd.com/read/38509240/increasing-obstructive-sleep-apnea-risk-is-associated-with-albuminuria-in-korean-adults-cross-sectional-analysis
#31
JOURNAL ARTICLE
Suk Won Chang, Ju Wan Kang
Several studies have shown an association between albuminuria and obstructive sleep apnea (OSA). However, studies on the relationship between the STOP-BANG questionnaire that can screen for OSA and microalbuminuria are still insufficient. Therefore, this study attempted to clarify the relationship between microalbuminuria and OSA risk using the STOP-BANG questionnaire in Korean adults. A total of 7478 participants (3289 men and 4189 women) aged over 40 were enrolled in the Korean National Health and Nutrition Examination Survey from 2019 to 2020...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38509088/structure-of-antiviral-drug-bulevirtide-bound-to-hepatitis-b-and-d-virus%C3%A2-receptor-protein-ntcp
#32
JOURNAL ARTICLE
Hongtao Liu, Dariusz Zakrzewicz, Kamil Nosol, Rossitza N Irobalieva, Somnath Mukherjee, Rose Bang-Sørensen, Nora Goldmann, Sebastian Kunz, Lorenzo Rossi, Anthony A Kossiakoff, Stephan Urban, Dieter Glebe, Joachim Geyer, Kaspar P Locher
Cellular entry of the hepatitis B and D viruses (HBV/HDV) requires binding of the viral surface polypeptide preS1 to the hepatobiliary transporter Na+ -taurocholate co-transporting polypeptide (NTCP). This interaction can be blocked by bulevirtide (BLV, formerly Myrcludex B), a preS1 derivative and approved drug for treating HDV infection. Here, to elucidate the basis of this inhibitory function, we determined a cryo-EM structure of BLV-bound human NTCP. BLV forms two domains, a plug lodged in the bile salt transport tunnel of NTCP and a string that covers the receptor's extracellular surface...
March 20, 2024: Nature Communications
https://read.qxmd.com/read/38508697/assessment-of-the-inflammatory-effects-of-gut-microbiota-from-human-twins-discordant-for-ulcerative-colitis-on-germ-free-mice
#33
JOURNAL ARTICLE
Lina A Knudsen, Zachariassen Line Sf, Mikael L Strube, Jesper F Havelund, Bartosz Pilecki, Anders B Nexoe, Frederik T Moller, Signe B Sørensen, Niels Marcussen, Nils J Færgeman, Andre Franke, Corinna Bang, Uffe Holmskov, Axel K Hansen, Vibeke Andersen
Disturbances in gut microbiota are prevalent in inflammatory bowel disease (IBD), which includes ulcerative colitis (UC). However, whether these disturbances contribute to development of the disease or are a result of the disease is unclear. In pairs of human twins discordant for IBD, the healthy twin has a higher risk of developing IBD and a gut microbiota that is more similar to that of IBD patients as compared with healthy individuals. Furthermore, appropriate medical treatment may mitigate these disturbances...
March 20, 2024: Comparative Medicine
https://read.qxmd.com/read/38508004/operational-mode-and-powdered-activated-carbon-promoting-syntrophic-propionate-oxidation-during-anaerobic-digestion-of-complex-organic-substances
#34
JOURNAL ARTICLE
Mabruk Adams, Yuyin Wang, Bang Du, Indiana Olbert, Guangxue Wu
Operational mode and powdered activated carbon (PAC) are key factors facilitating microbial syntrophy and interspecies electron transfer during anaerobic digestion, consequently benefiting process stability and efficient methanogenesis. In this study, continuous-flow reactor (CFR) and sequencing batch reactor (SBR), with and without the addition of PAC, respectively, were operated to examine their effects on system performance and methanogenic activity. Based on the cycle-test result, the PAC-amended CFR (CFRPAC ) recorded both the highest methane yield (690...
March 19, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38504103/5-ht_fastr-a-versatile-label-free-high-throughput-fluorescence-based-microplate-assay-to-quantify-serotonin-transport-and-release
#35
JOURNAL ARTICLE
Lina Bukowski, Markus Emanuel Strøm, Jens Lindengren Andersen, Jannick Bang Maesen, Lin Tian, Steffen Sinning
The neurotransmitter serotonin plays a pivotal role in mood and depression. It also acts as a vasoconstrictor within blood vessels and is the main neurotransmitter in the gastrointestinal system. In neurotransmission, released serotonin is taken up by serotonin transporters, which are principal targets of antidepressants and the psychostimulant, ecstasy. The investigation of serotonin transporters have relied almost exclusively on the use of radiolabeled serotonin in heterogenous end-point assays. Here we adapt the genetically encoded fluorescent biosensor, iSeroSnFR, to establish and validate the Serotonin (5-HT) Fluorescence Assay for Transport and Release (5-HT_FAsTR) for functional and pharmacological studies of serotonin transport and release...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38504063/benefit-and-risk-of-oral-anticoagulant-initiation-strategies-in-patients-with-atrial-fibrillation-and-cancer-a-target-trial-emulation-using-the-seer-medicare-database
#36
JOURNAL ARTICLE
Bang Truong, Lori Hornsby, Brent Fox, Chiahung Chou, Jingyi Zheng, Jingjing Qian
Oral anticoagulants (OACs) are recommended for patients with atrial fibrillation (AFib) having CHA2 DS2 -VASc score ≥ 2. However, the benefits of OAC initiation in patients with AFib and cancer at different levels of CHA2 DS2 -VASc is unknown. We included patients with new AFib diagnosis and a record of cancer (breast, prostate, or lung) from the 2012-2019 Surveillance, Epidemiology, and End Results (SEER)-Medicare database (n = 39,915). Risks of stroke and bleeding were compared between 5 treatment strategies: (1) initiated OAC when CHA2 DS2 -VASc ≥ 1 (n = 6008), (2) CHA2 DS2 -VASc ≥ 2 (n = 8694), (3) CHA2 DS2 -VASc ≥ 4 (n = 20,286), (4) CHA2 DS2 -VASc ≥ 6 (n = 30,944), and (5) never initiated OAC (reference group, n = 33,907)...
March 20, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38504043/inter-night-variability-of-in-home-overnight-pulse-oximetry-screening-in-an-asymptomatic-older-adult-population
#37
JOURNAL ARTICLE
Attiqa Chaudhary, Carla J Abbott, Zhichao Wu, Wendy Y Fang, Palaniraj R Raj, Matthew T Naughton, Robyn H Guymer
PURPOSE: Obstructive sleep apnoea (OSA) is common, yet often undiagnosed. Self-administered, overnight pulse oximetry (OPO) could screen for OSA in asymptomatic, older populations. However, the inter-night variability of OPO in an asymptomatic, older population is unknown. We determined the inter-night variability of home OPO parameters in an older population and correlated with sleep questionnaires. METHODS: Participants > 50 years without a diagnosis of OSA undertook home OPO for three consecutive nights and completed two sleep questionnaires (STOP-BANG (SBQ) and Epworth Sleepiness Score (ESS))...
March 19, 2024: Sleep & Breathing
https://read.qxmd.com/read/38501315/glymphatic-system-dysfunction-predicts-amyloid-deposition-neurodegeneration-and-clinical-progression-in-alzheimer-s-disease
#38
JOURNAL ARTICLE
Shu-Yi Huang, Ya-Ru Zhang, Yu Guo, Jing Du, Peng Ren, Bang-Sheng Wu, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
INTRODUCTION: Although glymphatic function is involved in Alzheimer's disease (AD), its potential for predicting the pathological and clinical progression of AD and its sequential association with core AD biomarkers is poorly understood. METHODS: Whole-brain glymphatic activity was measured by diffusion tensor image analysis along the perivascular space (DTI-ALPS) in participants with AD dementia (n = 47), mild cognitive impairment (MCI; n = 137), and normal controls (n = 235) from the Alzheimer's Disease Neuroimaging Initiative...
March 19, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38500659/case-report-pembrolizumab-as-an-alternative-to-atezolizumab-following-a-severe-infusion-reaction
#39
Seung Hyuk Lee, Hyeon Jong Kim, Hyun Jin Bang, Su Ji Park, Ji Eun Yu, Seung Woo Jeong, Woo Kyun Bae
The emergence of immune-checkpoint inhibitors (ICIs) has revolutionized the field of oncology, providing promising results in various malignancies. However, ICIs can sometimes lead to severe injection reactions, requiring alternative treatment options. In this case report, we introduce a case of a severe infusion reaction induced by atezolizumab. After atezolizumab infusion, the patient experienced symptoms that were suggestive of anaphylactic shock, including chest tightness, low blood pressure, and loss of consciousness, all of which were restored by immediate administration of steroid, antihistamine, and epinephrine...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38500298/taming-the-terminological-tempest-in-invasion-science
#40
JOURNAL ARTICLE
Ismael Soto, Paride Balzani, Laís Carneiro, Ross N Cuthbert, Rafael Macêdo, Ali Serhan Tarkan, Danish A Ahmed, Alok Bang, Karolina Bacela-Spychalska, Sarah A Bailey, Thomas Baudry, Liliana Ballesteros-Mejia, Alejandro Bortolus, Elizabeta Briski, J Robert Britton, Miloš Buřič, Morelia Camacho-Cervantes, Carlos Cano-Barbacil, Denis Copilaș-Ciocianu, Neil E Coughlan, Pierre Courtois, Zoltán Csabai, Tatenda Dalu, Vanessa De Santis, James W E Dickey, Romina D Dimarco, Jannike Falk-Andersson, Romina D Fernandez, Margarita Florencio, Ana Clara S Franco, Emili García-Berthou, Daniela Giannetto, Milka M Glavendekic, Michał Grabowski, Gustavo Heringer, Ileana Herrera, Wei Huang, Katie L Kamelamela, Natalia I Kirichenko, Antonín Kouba, Melina Kourantidou, Irmak Kurtul, Gabriel Laufer, Boris Lipták, Chunlong Liu, Eugenia López-López, Vanessa Lozano, Stefano Mammola, Agnese Marchini, Valentyna Meshkova, Marco Milardi, Dmitrii L Musolin, Martin A Nuñez, Francisco J Oficialdegui, Jiří Patoka, Zarah Pattison, Daniel Pincheira-Donoso, Marina Piria, Anna F Probert, Jes Jessen Rasmussen, David Renault, Filipe Ribeiro, Gil Rilov, Tamara B Robinson, Axel E Sanchez, Evangelina Schwindt, Josie South, Peter Stoett, Hugo Verreycken, Lorenzo Vilizzi, Yong-Jian Wang, Yuya Watari, Priscilla M Wehi, András Weiperth, Peter Wiberg-Larsen, Sercan Yapıcı, Baran Yoğurtçuoğlu, Rafael D Zenni, Bella S Galil, Jaimie T A Dick, James C Russell, Anthony Ricciardi, Daniel Simberloff, Corey J A Bradshaw, Phillip J Haubrock
Standardised terminology in science is important for clarity of interpretation and communication. In invasion science - a dynamic and rapidly evolving discipline - the proliferation of technical terminology has lacked a standardised framework for its development. The result is a convoluted and inconsistent usage of terminology, with various discrepancies in descriptions of damage and interventions. A standardised framework is therefore needed for a clear, universally applicable, and consistent terminology to promote more effective communication across researchers, stakeholders, and policymakers...
March 18, 2024: Biological Reviews of the Cambridge Philosophical Society
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