Holger Eltzschig, Wei Ruan, Tao Li, Jaewoong Lee, In Hyuk Bang, Wankun Deng, Xinxin Ma, Seung-Hee Yoo, Boyun Kim, Jiwen Li, Xiaoyi Yuan, Yu An, Yin-Ying Wang, Yafen Liang, Matthew Deberge, Dongze Zhang, Zhen Zhou, Yanyu Wang, Joshua Gorham, Jonathan Seidman, Christine Seidman, Sary Aranki, Ragini Nair, Lei Li, Jagat Narula, Zhongming Zhao, Alemayehu Gorfe, Jochen Muehlschlegel, Kuang-Lei Tsai
Acute myocardial infarction stands as a prominent cause of morbidity and mortality worldwide 1-6 . Clinical studies have demonstrated that the severity of cardiac injury following myocardial infarction exhibits a circadian pattern, with larger infarct sizes and poorer outcomes in patients experiencing morning onset myocardial infarctions 7-14 . However, the molecular mechanisms that govern circadian variations of myocardial injury remain unclear. Here, we show that BMAL1 14-20 , a core circadian transcription factor, orchestrates diurnal variability in myocardial injury...
February 28, 2024: Research Square