keyword
https://read.qxmd.com/read/38492343/the-nlrp3-inhibitor-olt1177-attenuates-brain-injury-in-experimental-intracerebral-hemorrhage
#1
JOURNAL ARTICLE
Mei Fang, Fan Xia, Jiayan Wang, Chengyang Wang, Bang Teng, Shenglan You, Manrui Li, Xiameng Chen, Xin Hu
BACKGROUND AND PURPOSE: It has been reported activation of NLRP3 inflammasome after intracerebral hemorrhage (ICH) ictus exacerbates neuroinflammation and brain injury. We hypothesized that inhibition of NLRP3 by OLT1177 (dapansutrile), a novel NLRP3 inflammasome inhibitor, could reduce brain edema and attenuate brain injury in experimental ICH. METHODS: ICH was induced by injection of autologous blood into basal ganglia in mice models. Sixty-three C57Bl/6 male mice were randomly grouped into the sham, vehicle, OLT1177 (Dapansutrile, 200 mg/kg intraperitoneally) and treated for consecutive three days, starting from 1 h after ICH surgery...
March 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38491406/characterization-of-diverse-lysine-acylations-in-bacillus-thuringiensis-substrate-profiling-and-functional-exploration
#2
JOURNAL ARTICLE
Tianxian Liu, Mingya Zhang, Yameng Fan, Lei Zhao, Dan Huang, Liuchang Zhao, Minjia Tan, Bang-Ce Ye, Jun-Yu Xu
Lysine acylation has been extensively investigated due to its regulatory role in a diverse range of biological functions across prokaryotic and eukaryotic species. In-depth acylomic profiles have the potential to enhance comprehension of the biological implications of organisms. However, the extent of research on global acylation profiles in microorganisms is limited. Here, four lysine acylomes were conducted in Bacillus thuringiensis by using the LC-MS/MS based proteomics combined with antibody-enrichment strategies, and a total of 3438 acetylated sites, 5797 propionylated sites, 1705 succinylated sites, and 925 malonylated sites were identified...
March 15, 2024: Proteomics
https://read.qxmd.com/read/38490734/relationship-between-in-stent-restenosis-following-carotid-artery-stenting-and-platelet-reactivity-to-clopidogrel
#3
JOURNAL ARTICLE
Min-Yong Kwon, Sang Hyo Lee, Yongjae Lee, Young Deok Kim, Si Un Lee, Jae Seung Bang, O-Ki Kwon, Chang Wan Oh, Seung Pil Ban
OBJECTIVE: To analyze the relationship between in-stent restenosis (ISR) following carotid artery stenting (CAS) and platelet clopidogrel reactivity confirmed by the P2Y12 reaction unit (PRU) and inhibition rate (IR). METHODS: We retrospectively analyzed 171 patients who underwent CAS with extracranial carotid stenosis from January 2016 to December 2019. Dual antiplatelet therapy with 100 mg aspirin and 75 mg clopidogrel was started ≥5 days before CAS...
March 15, 2024: Journal of Neurointerventional Surgery
https://read.qxmd.com/read/38489019/attention-deficit-hyperactivity-disorder-adhd-medication-use-trajectories-among-women-in-the-perinatal-period
#4
JOURNAL ARTICLE
Kathrine Bang Madsen, Mette Bliddal, Charlotte Borg Skoglund, Henrik Larsson, Trine Munk-Olsen, Malene Galle Madsen, Per Hove Thomsen, Veerle Bergink, Chaitra Srinivas, Jacqueline M Cohen, Isabell Brikell, Xiaoqin Liu
BACKGROUND: An increasing number of women of reproductive age are treated with attention-deficit hyperactivity disorder (ADHD) medication; however, patterns of ADHD medication use for women in the perinatal period have not been well described. OBJECTIVE: This study aimed to describe ADHD medication use patterns from 1 year before pregnancy to 1 year after delivery, and to describe sociodemographic characteristics and clinical features by medication trajectories...
March 15, 2024: CNS Drugs
https://read.qxmd.com/read/38485775/obstructive-sleep-apnea-in-relation-to-beat-to-beat-reading-to-reading-and-day-to-day-blood-pressure-variability
#5
JOURNAL ARTICLE
Yi-Bang Cheng, Qian-Hui Guo, Jia-Hui Xia, Jin Zhang, Ting-Yan Xu, Yan Li, Ji-Guang Wang
We investigated blood pressure (BP) variability as assessed by beat-to-beat, reading-to-reading and day-to-day BP variability indices in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). In 786 hospitalized hypertensives (mean age, 53.2 years; 42.2% women), we performed 10-min beat-to-beat (n = 705), 24-h ambulatory (n = 779), and 7-day home BP (n = 445) measurements and the full overnight polysomnography. Mild, moderate and severe OSAHS were defined as an apnea-hypopnea index of 5-14, 15-29, and ≥ 30 events per hour, respectively...
March 14, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38484383/three-polyoxometalate-based-ag-organic-compounds-as-heterogeneous-catalysts-for-the-synthesis-of-benzimidazoles
#6
JOURNAL ARTICLE
Yu-Feng Liu, Xiao-Ling Lin, Bang-Ming Ming, Qi-Long Hu, Hao-Qi Liu, Xue-Jiao Chen, Yun-Hai Liu, Guo-Ping Yang
Three new POM-based compounds, with formulae [Na0.63 Ag3 (Htba)2.37 (tba)0.63 (H2 O)2 (PMo12 O40 )]·4H2 O ( Ag 3 PMo ), [Ag4 (Htba)4 (H2 O)2 (PMo12 O40 )](NO3 )·H2 O ( Ag 4 PMo ), and [Ag3 (Htba)2 (tba)(PW12 O40 )0.5 ](NO3 )0.5 ·13H2 O ( Ag 3 PW ), were prepared with a 3-(4 H -1,2,4-triazol-4-yl)benzoic acid (Htba) ligand, Keggin-type anions ([PMo12 O40 ]3- /[PW12 O40 ]3- ), and a silver ion (Ag+ ). The structural features of these compounds are particularly different from the multinuclear subunits, which are [Ag3 (tba)3 ] clusters in Ag 3 PMo , [Ag4 (tba)3 ] chains in Ag 4 PMo , and [Ag3 (tba)3 ]2 clusters in Ag 3 PW , connected by multidonor atom tba ligands and Ag+ ions...
March 14, 2024: Inorganic Chemistry
https://read.qxmd.com/read/38483910/deaths-and-cardiopulmonary-events-following-colorectal-cancer-screening-a-systematic-review-with-meta-analyses
#7
JOURNAL ARTICLE
Frederik Handberg Juul Martiny, Anne Katrine Lykke Bie, Christian Patrick Jauernik, Or Joseph Rahbek, Sigrid Brisson Nielsen, Emma Grundtvig Gram, Isabella Kindt, Volkert Siersma, Christine Winther Bang, John Brandt Brodersen
BACKGROUND: Colorectal cancer screening programmes (CRCSPs) are implemented worldwide despite recent evidence indicating more physical harm occurring during CRCSPs than previously thought. Therefore, we aimed to review the evidence on physical harms associated with endoscopic diagnostic procedures during CRCSPs and, when possible, to quantify the risk of the most serious types of physical harm during CRCSPs, i.e. deaths and cardiopulmonary events (CPEs). METHODS: Systematic review with descriptive statistics and random-effects meta-analyses of studies investigating physical harms following CRCSPs...
2024: PloS One
https://read.qxmd.com/read/38483879/correction-inferring-school-district-learning-modalities-during-the-covid-19-pandemic-with-a-hidden-markov-model
#8
Mark J Panaggio, Mike Fang, Hyunseung Bang, Paige A Armstrong, Alison M Binder, Julian E Grass, Jake Magid, Marc Papazian, Carrie K Shapiro-Mendoza, Sharyn E Parks
[This corrects the article DOI: 10.1371/journal.pone.0292354.].
2024: PloS One
https://read.qxmd.com/read/38483767/an-8-year-prospective-observational-multi-centre-post-marketing-safety-surveillance-study-conducted-in-south-korea-2014-2022-following-the-introduction-of-gsk-s-inactivated-quadrivalent-seasonal-influenza-vaccine-fluarix-tetra-for-subjects-aged-6-months-and
#9
JOURNAL ARTICLE
Gaël Dos Santos, Raghavendra Devadiga, Chun Soo Kim, Joon Bang
INTRODUCTION: Seasonal influenza is associated with substantial public health burden. The objective of this study was to assess the safety of inactivated quadrivalent seasonal influenza vaccine (IIV4, Fluarix Tetra, GSK, Belgium) in subjects aged ≥ 6 months in Korea. METHODS: This prospective, observational, non-comparative, multi-centre post-marketing surveillance study was conducted in Korea in subjects aged ≥ 3 years for 6 years (2014-2020) and extended to subjects aged 6-35 months for 4 years (2018-2022)...
March 14, 2024: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://read.qxmd.com/read/38481807/interruption-of-p38-mapk-msk1-creb-mitf-m-pathway-to-prevent-hyperpigmentation-in-the-skin
#10
JOURNAL ARTICLE
Song-Hee Kim, Jiyeon Lee, Jihye Jung, Ga Hyun Kim, Cheong-Yong Yun, Sang-Hun Jung, Bang Yeon Hwang, Jin Tae Hong, Sang-Bae Han, Jae-Kyung Jung, Youngsoo Kim
Background: Melanocortin 1 receptor (MC1R), a receptor of α-melanocyte-stimulating hormone (α-MSH), is exclusively present in melanocytes where α-MSH/MC1R stimulate melanin pigmentation through microphthalmia-associated transcription factor M (MITF-M). Toll-like receptor 4 (TLR4), a receptor of endotoxin lipopolysaccharide (LPS), is distributed in immune and other cell types including melanocytes where LPS/TLR4 activate transcriptional activity of nuclear factor (NF)-κB to express cytokines in innate immunity...
2024: International Journal of Biological Sciences
https://read.qxmd.com/read/38481585/risk-of-obstructive-sleep-apnea-and-its-relation-to-cognitive-functions-among-saudi-older-adults
#11
JOURNAL ARTICLE
Yousef D Alqurashi, Khalid AlHarkan, Adam Aldhawyan, Ahmed Bahamdan, Fajar A Aldulijan, Sarah I Alsamin, Jood K Alotaibi, Arwa Alomran, Feras A Al-Awad
BACKGROUND: The association between obstructive sleep apnea (OSA) and cognitive decline among older adults is a still a topic of debate. Objective: The aim of this study was to determine the association between risk of OSA and cognitive function among Saudi older adults. METHODS: This was a cross-sectional community-based study conducted between July and October 2022. Participants were recruited from gathering areas where older adults are likely attending such as district centers, waiting areas of shopping malls, and mosques...
2024: Medical Archives
https://read.qxmd.com/read/38481356/comparison-of-analgesic-effects-between-programmed-intermittent-epidural-boluses-and-continuous-epidural-infusion-after-cesarean-section-a-randomized-controlled-study
#12
JOURNAL ARTICLE
Yu Jeong Bang, Heejoon Jeong, RyungA Kang, Ji-Hee Sung, Suk-Joo Choi, Soo-Young Oh, Tae Soo Hahm, Soo Joo Choi, You Jin Seong, Justin Sangwook Ko
BACKGROUND: This study aimed to compare the analgesic effects of programmed intermittent epidural boluses (PIEB) and continuous epidural infusion (CEI) for postoperative analgesia after elective cesarean section (CS). METHODS: Seventy-four women who underwent elective CS were randomized to receive either PIEB or CEI. The PIEB group received 4 ml-intermittent boluses of 0.11% ropivacaine every hour at a rate of 120 ml/h. The CEI group received a constant rate of 4 ml/h of 0...
March 14, 2024: Korean Journal of Anesthesiology
https://read.qxmd.com/read/38480902/dysregulated-creb3-cleavage-at-the-nuclear-membrane-induces-karyoptosis-mediated-cell-death
#13
JOURNAL ARTICLE
Ga-Eun Lee, Geul Bang, Jiin Byun, Cheol-Jung Lee, Weidong Chen, Dohyun Jeung, Hyun-Jung An, Han Chang Kang, Joo Young Lee, Hye Suk Lee, Young-Soo Hong, Dae Joon Kim, Megan Keniry, Jin Young Kim, Jin-Sung Choi, Manolis Fanto, Sung-Jun Cho, Kwang-Dong Kim, Yong-Yeon Cho
Cancer cells often exhibit resistance to apoptotic cell death, but they may be vulnerable to other types of cell death. Elucidating additional mechanisms that govern cancer cell death is crucial for developing new therapies. Our research identified cyclic AMP-responsive element-binding protein 3 (CREB3) as a crucial regulator and initiator of a unique cell death mechanism known as karyoptosis. This process is characterized by nuclear shrinkage, deformation, and the loss of nuclear components following nuclear membrane rupture...
March 13, 2024: Experimental & Molecular Medicine
https://read.qxmd.com/read/38480766/a-pilot-observation-using-ultrasonography-and-vowel-articulation-to-investigate-the-influence-of-suspected-obstructive-sleep-apnea-on-upper-airway
#14
JOURNAL ARTICLE
Shumit Saha, Anand Rattansingh, Rosemary Martino, Keerthana Viswanathan, Anamika Saha, Nasim Montazeri Ghahjaverestan, Azadeh Yadollahi
Failure to employ suitable measures before administering full anesthesia to patients with obstructive sleep apnea (OSA) who are undergoing surgery may lead to developing complications after surgery. Therefore, it is very important to screen OSA before performing a surgery, which is currently done by subjective questionnaires such as STOP-Bang, Berlin scores. These questionnaires have 10-36% specificity in detecting sleep apnea, along with no information given on anatomy of upper airway, which is important for intubation...
March 13, 2024: Scientific Reports
https://read.qxmd.com/read/38480309/the-first-record-of-the-giant-pill-millipede-genus-prionobelum-verhoeff-1924-from-thailand-with-the-integrative-description-of-two-species-diplopoda-sphaerotheriida-zephroniidae
#15
JOURNAL ARTICLE
Patrick Donworth, Thomas Wesener
Thailand hosts a very rich but underexplored giant pill-millipede (Sphaerotheriida) fauna, with 11 of its 13 species described in the last three years. Currently, all known Thai giant pill-millipedes belong to the genera Zephronia Gray, 1832 (nine species) and Sphaerobelum Verhoeff, 1924 (four species). Here we describe the first two species of the genus Prionobelum Verhoeff, 1924 (previously restricted to Vietnam and China), Prionobelum inthanonense n. sp. and P. naevium n. sp. from Thailand. The species occur at Thailands highest mountain (2500 m) Doi Inthanon and the lowland rainforests at Bang Lang National Park touching the border with Malaysia...
March 8, 2024: Zootaxa
https://read.qxmd.com/read/38479620/undescribed-2-7-neolignans-and-polyoxygenated-cyclohexene-glycosides-from-the-aerial-parts-of-piper-mutabile-c-dc-and-their-inhibitory-effects-on-nitric-oxide-production
#16
JOURNAL ARTICLE
Phan Van Kiem, Nguyen Xuan Nhiem, Nguyen Huy Hoang, Ngo Anh Bang, Pham Hai Yen, Do Thi Trang, Duong Thi Dung, Nguyen Thi Cuc, Phan Thi Thanh Huong, Bui Huu Tai
A phytochemical study of the aerial parts of Piper mutabile C. DC. revealed seven undescribed compounds [two (2-7')-neolignans and five polyoxygenated cyclohexene glycosides] and six known propenylcatechol derivatives. The chemical structures of the isolated compounds were elucidated by extensive HR-ESI-MS and NMR analyses, as well as comparison with the literature. The absolute configurations of the (2-7')-neolignans were confirmed by GIAO 13 C NMR calculations with a sorted training set strategy and TD-DFT calculation ECD spectra...
March 11, 2024: Fitoterapia
https://read.qxmd.com/read/38476944/the-archaeome-in-metaorganism-research-with-a-focus-on-marine-models-and-their-bacteria-archaea-interactions
#17
JOURNAL ARTICLE
Avril J E von Hoyningen-Huene, Corinna Bang, Philipp Rausch, Malte Rühlemann, Hanna Fokt, Jinru He, Nadin Jensen, Mirjam Knop, Carola Petersen, Lara Schmittmann, Thorsten Zimmer, John F Baines, Thomas C G Bosch, Ute Hentschel, Thorsten B H Reusch, Thomas Roeder, Andre Franke, Hinrich Schulenburg, Eva Stukenbrock, Ruth A Schmitz
Metaorganism research contributes substantially to our understanding of the interaction between microbes and their hosts, as well as their co-evolution. Most research is currently focused on the bacterial community, while archaea often remain at the sidelines of metaorganism-related research. Here, we describe the archaeome of a total of eleven classical and emerging multicellular model organisms across the phylogenetic tree of life. To determine the microbial community composition of each host, we utilized a combination of archaea and bacteria-specific 16S rRNA gene amplicons...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38476641/the-role-of-ki-67-in-hr-her2-breast-cancer-a-real-world-study-of-956-patients
#18
JOURNAL ARTICLE
Qin Ma, Yao-Bang Liu, Tong She, Xin-Lan Liu
OBJECTIVE: This study determined the cut-off value of Ki-67 expression and discussed the interaction between Ki-67 and histological grade, further explored the prognostic role of Ki-67 in hormone receptor-positive and human epidermal growth factor receptor 2 negative (HR+/HER2-) breast cancer;. MATERIALS AND METHODS: We assessed the Ki-67 expression of 956 patients with HR+/HER2 breast cancer diagnosed in the General Hospital of Ningxia Medical University from 2015 to 2019 by immunohistochemistry (IHC), The disease-free survival (DFS) was defined as the time from postoperative to the first local recurrence, distant metastasis or death of the disease...
2024: Breast Cancer: Targets and Therapy
https://read.qxmd.com/read/38476500/association-between-risk-of-obstructive-sleep-apnea-severity-and-risk-of-severe-covid-19-symptoms-insights-from-salivary-and-serum-cytokines
#19
JOURNAL ARTICLE
Yen Dinh, Abdullah Alawady, Hesham Alhazmi, Khaled Altabtbaei, Marcelo Freire, Mohammad Alghounaim, Sriraman Devarajan, Fahd Al Mulla, Saadoun Bin-Hassan, Hend Alqaderi
OBJECTIVES: Obstructive sleep apnea (OSA) can adversely affect the immune response through clinical factors such as hypoxia, inflammation, and sleep disturbance. Since SARS-CoV-2 heavily relies on local and systemic host immune responses, this study aims to examine the links between the severity of OSA risk, cytokine levels, and the severity of symptoms associated with SARS-CoV-2 infection. METHODS: Saliva and blood samples from 50 COVID-19 patients and 30 non-infected hospital staff members were collected...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38474982/entropy-sharing-in-ransomware-bypassing-entropy-based-detection-of-cryptographic-operations
#20
JOURNAL ARTICLE
Jiseok Bang, Jeong Nyeo Kim, Seungkwang Lee
This study presents a groundbreaking approach to the ever-evolving challenge of ransomware detection. A lot of detection methods predominantly rely on pinpointing high-entropy blocks, which is a hallmark of the encryption techniques commonly employed in ransomware. These blocks, typically difficult to recover, serve as key indicators of malicious activity. So far, many neutralization techniques have been introduced so that ransomware utilizing standard encryption can effectively bypass these entropy-based detection systems...
February 23, 2024: Sensors
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