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https://www.readbyqxmd.com/read/28547726/stroke-induces-mesenchymal-stem-cell-migration-to-infarcted-brain-areas-via-cxcr4-and-c-met-signaling
#1
Oh Young Bang, Gyeong Joon Moon, Dong Hee Kim, Ji Hyun Lee, Sooyoon Kim, Jeong Pyo Son, Yeon Hee Cho, Won Hyuk Chang, Yun-Hee Kim
Mesenchymal stem cells circulate between organs to repair and maintain tissues. Mesenchymal stem cells cultured with fetal bovine serum have therapeutic effects when intravenously administered after stroke. However, only a small number of mesenchymal stem cells reach the brain. We hypothesized that the serum from stroke patients increases mesenchymal stem cells trophism toward the infarcted brain area. Mesenchymal stem cells were grown in fetal bovine serum, normal serum from normal rats, or stroke serum from ischemic stroke rats...
May 25, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28544461/semi-ipns-with-moisture-triggered-shape-memory-and-self-healing-properties
#2
Zhi-Chao Jiang, Yao-Yu Xiao, Yang Kang, Bang-Jing Li, Sheng Zhang
Moisture or water has the advantages of being green, inexpensive, and moderate. However, it is challenging to endow water-induced shape memory property and self-healing capability to one single polymer because of the conflicting structural requirement of the two types of materials. In this study, this problem is solved through introducing two kinds of supramolecular interactions into semi-interpenetrating polymer networks (semi-IPNs). The hydrogen bonds function as water-sensitive switches, making the materials show moisture-induced shape memory effect...
May 23, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28543663/lncrna-malat1-promotes-angiogenesis-of-thyroid-cancer-by-modulating-tumor-associated-macrophage-fgf2-protein-secretion
#3
Jian-Kang Huang, Wen-Hua Song, Bang-Yu Lu, Yu-Bin Huang, Hui-Ming Dong, Xiao-Kai Ma, Zheng-Zhi Zhu, Rui Zhou, Ling Ma
OBJECTIVE: Tumor-associated macrophages (TAMs) in the tumor microenvironment have been associated with enhanced tumor progression. In this study, we investigated the role and molecular mechanisms of MALAT1 in TAMs derived from thyroid cancer. METHODS: The expression of MALAT1 and FGF2 in thyroid cancer tissues and cells were measured by quantitative real-time PCR and western blot. TAMs were transfected with indicated constructs. Then the culture medium (CM) from TAMs was harvested for assay...
May 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28543392/mechanical-analysis-of-the-vascularized-fibular-graft-prosthetic-composite-vfgpc-for-internal-hemipelvectomy-reconstruction
#4
Jonathan Morris, Rui Yang, Michael Roth, Jonathan Gill, Richard Gorlick, Yungtai Lo, Bang H Hoang, Evan Garfein, David S Geller
INTRODUCTION: The vascularized fibular graft prosthetic composite (VFGPC) is used for reconstruction after internal hemipelvectomy. The purpose of this study was to create a mathematical model that calculates the mechanical effects of the vascularized fibular graft on the VFGPC. METHODS: The effects of the VFG positioning were calculated based on three-dimensional static analyzes to determine the direction, magnitude, and distribution of the forces through the prosthesis and VFG...
May 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28542543/knowledge-deficit-attitude-and-behavior-scales-association-to-objective-measures-of-sun-exposure-and-sunburn-in-a-danish-population-based-sample
#5
Brian Køster, Jens Søndergaard, Jesper Bo Nielsen, Karl Bang Christensen, Martin Allen, Anja Olsen, Joan Bentzen
The objective of this study was to develop new scales measuring knowledge and attitude about UVR and sun related behavior, and to examine their association to sun related behavior objectively measured by personal dosimetry. During May-August 2013, 664 Danes wore a personal electronic UV-dosimeter for one week that measured their UVR exposure. Afterwards, they answered a questionnaire on sun-related items. We applied descriptive analysis, linear and logistic regression analysis to evaluate the associations between the questionnaire scales and objective UVR measures...
2017: PloS One
https://www.readbyqxmd.com/read/28542415/pharmacological-thromboprophylaxis-and-its-impact-on-venous-thromboembolism-following-total-knee-and-hip-arthroplasty-in-korea-a-nationwide-population-based-study
#6
Ho-Young Yhim, Juhyun Lee, Ji Yun Lee, Jeong-Ok Lee, Soo-Mee Bang
BACKGROUND: Limited data is available regarding the pharmacological prophylaxis for venous thromboembolism (VTE) in Asian patients undergoing total knee arthroplasty or total hip arthroplasty (TKA/THA). METHODS: We performed a population-based epidemiological study using the Health Insurance Review and Assessment Service database to estimate the rate of pharmacological thromboprophylaxis and its impact on VTE in Korean patients who underwent TKA/THA between 2009 and 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28541818/preparation-and-characterization-of-monodisperse-microcapsules-with-alginate-and-bentonite-via-external-gelation-technique-encapsulating-pseudomonas-putida-rs-198
#7
Xuan Li, Zhansheng Wu, Yanhui He, Bang-Ce Ye, Jun Wang
This paper evaluated the external gelation technique for preparing microcapsules. The microcapsules were consisted of Pseudomonas putida Rs-198 (Rs-198) core and sodium alginate (NaAlg)-bentonite (Bent) shell. Different emulsification rotation speeds and core/shell ratios were used to prepare the microcapsules of each formulation. The near-spherical microcapsules were monodisperse with a mean diameter of 25 μm to 100 μm and wrinkled surfaces. Fourier transform infrared spectrophotometry (FTIR) and thermogravimetric analysis (TGA) revealed the physical mixture of the wall material and the superior thermal stability of the microcapsules...
May 25, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28541533/predictive-performance-of-the-modified-marsh-and-schnider-models-for-propofol-in-underweight-patients-undergoing-general-anaesthesia-using-target-controlled-infusion
#8
Y H Lee, G H Choi, K W Jung, B H Choi, J Y Bang, E K Lee, B M Choi, G J Noh
Background: : In our preliminary study, the modified Marsh (M-Marsh) model caused an inadvertent underdosing of propofol in underweight patients. However, the predictive performance of the M-Marsh and Schnider models incorporated in commercially available target-controlled infusion (TCI) pumps was not evaluated in underweight patients. Methods: : Thirty underweight patients undergoing elective surgery were randomly allocated to receive propofol via TCI using the M-Marsh or Schnider models...
May 24, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28540999/do-cerclage-cables-delay-the-time-to-bone-union-in-patients-with-an-unstable-humeral-shaft-fracture-treated-with-intramedullary-nails
#9
Kyeong Jin Han, Doo Hyung Lee, Joon Young Bang
PURPOSE: To evaluate the time to bone union after open reduction and internal fixation with cerclage cables followed by intramedullary nailing (IMN) for unstable humeral shaft fractures. MATERIALS AND METHODS: Patients with a humeral shaft fracture treated by IMN were enrolled. One group of patients was treated via open reduction and internal fixation with cables followed by IMN (cable group; n=32), while the other group was treated with a conventional closed IMN (non-cable group; n=64)...
July 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28539332/identification-and-characterization-of-two-types-of-amino-acid-regulated-acetyltransferases-in-actinobacteria
#10
Yu-Xing Lu, Xin-Xin Liu, Wei-Bin Liu, Bang-Ce Ye
One hundred and fifty GCN5-like acetyltransferases with amino acid-binding (ACT)-GCN5-related N- acetyltransferase (GNAT) domain organization have been identified in actinobacteria. The ACT domain is fused to the GNAT domain, conferring amino acid-induced allosteric regulation to these protein acetyltransferases (AAPatA). Members of the AAPatA family share similar secondary structure and are divided into two groups based on the allosteric ligands of the ACT domain: the asparagine-activated PatA and the cysteine-activated PatA...
May 24, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28539126/knowledge-driven-binning-approach-for-rare-variant-association-analysis-application-to-neuroimaging-biomarkers-in-alzheimer-s-disease
#11
Dokyoon Kim, Anna O Basile, Lisa Bang, Emrin Horgusluoglu, Seunggeun Lee, Marylyn D Ritchie, Andrew J Saykin, Kwangsik Nho
BACKGROUND: Rapid advancement of next generation sequencing technologies such as whole genome sequencing (WGS) has facilitated the search for genetic factors that influence disease risk in the field of human genetics. To identify rare variants associated with human diseases or traits, an efficient genome-wide binning approach is needed. In this study we developed a novel biological knowledge-based binning approach for rare-variant association analysis and then applied the approach to structural neuroimaging endophenotypes related to late-onset Alzheimer's disease (LOAD)...
May 18, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28539115/quad-phased-data-mining-modeling-for-dementia-diagnosis
#12
Sunjoo Bang, Sangjoon Son, Hyunwoong Roh, Jihye Lee, Sungyun Bae, Kyungwon Lee, Changhyung Hong, Hyunjung Shin
BACKGROUND: The number of people with dementia is increasing along with people's ageing trend worldwide. Therefore, there are various researches to improve a dementia diagnosis process in the field of computer-aided diagnosis (CAD) technology. The most significant issue is that the evaluation processes by physician which is based on medical information for patients and questionnaire from their guardians are time consuming, subjective and prone to error. This problem can be solved by an overall data mining modeling, which subsidizes an intuitive decision of clinicians...
May 18, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28539035/the-performance-of-serum-biomarkers-for-predicting-fibrosis-in-patients-with-chronic-viral-hepatitis
#13
Chang Seok Bang, Ha Yan Kang, Gyu Ho Choi, Suk Bae Kim, Wonae Lee, Il Han Song
Background/Aims: The invasiveness of a liver biopsy and its inconsistent results have prompted efforts to develop noninvasive tools to evaluate the severity of chronic hepatitis. This study was intended to assess the performance of serum biomarkers for predicting liver fibrosis in patients with chronic viral hepatitis. Methods: A total of 302 patients with chronic hepatitis B or C, who had undergone liver biopsy, were retrospectively enrolled. We investigated the diagnostic accuracy of several clinical factors for predicting advanced fibrosis (F≥3)...
May 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28538289/a-three-dimensional-analysis-of-the-fracture-planes-in-pediatric-lateral-humeral-condyle-fractures-for-image-based-pin-positioning-during-fixation
#14
Do Young Park, Jae Ho Cho, Doo-Hyung Lee, Wan-Sun Choi, Jun Young Bang, Xiang Yun Yin
OBJECTIVE: To determine the 3 dimensional morphology of pediatric lateral condylar physeal fractures using 3-dimensional computed tomography (3D-CT) and to identify optimal pin positions for percutaneous pinning. DESIGN: Prospective case series of consecutively treated patients SETTING:: Tertiary university hospital setting. PATIENTS: Preoperative 3D-CTs in pediatric surgical candidates diagnosed with lateral condylar physeal fractures INTERVENTION:: Closed reduction and percutaneous pinning was performed...
May 17, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28538075/is-surgical-navigation-useful-for-treating-zygomatic-arch-fractures
#15
Min Kwan Baek, Joo Hyun Jung, Seon Tae Kim, Na Rae Oh, Yu Jin Bang, Il Gyu Kang
OBJECTIVE: To report the case of a 58-year-old man with a zygomatic arch fracture, which was well localized and reduced using a surgical navigation system. METHODS: In this clinical report, the authors suggest intraoperative surgical navigation systems are useful diagnostically and for localizing sites of zygomatic arch fractures. RESULTS: The patient underwent successful closed reduction of zygomatic arch fractures using a surgical navigation system...
May 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28536487/current-status-and-challenges-in-sentinel-node-navigation-surgery-for-early-gastric-cancer
#16
Bang Wool Eom, Young-Il Kim, Hong Man Yoon, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Soo Jin Kim, Ji Yoon Rho, Seok Ki Kim, Myeong-Cherl Kook, Young-Woo Kim, Keun Won Ryu
Although a number of feasibility studies for sentinel node (SN) concepts in gastric cancer have been conducted since 2000, there remains a debate regarding detailed detection techniques and oncological safety. Two important multicenter phase II clinical trials were performed in Japan that used different methods and reached different conclusions; one confirmed acceptable results with a false-negative rate of 7%, and the other showed an unacceptably high false-negative rate of 46.4%. The Sentinel Node Oriented Tailored Approach (SENORITA) trial is a multicenter randomized controlled phase III trial being performed in Korea...
April 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28536120/hepatocyte-specific-sirtuin-6-deletion-predisposes-to-nonalcoholic-steatohepatitis-by-up-regulation-of-bach1-an-nrf2-repressor
#17
Sun-O Ka, In Hyuk Bang, Eun Ju Bae, Byung-Hyun Park
Sirtuin (Sirt)6 has been implicated in negative regulation of inflammation and lipid metabolism, although its function in the progression from simple steatosis to nonalcoholic steatohepatitis (NASH) remains to be defined. To explore the role of hepatocyte Sirt6 in NASH development, we generated hepatocyte-specific Sirt6 knockout (KO) mice that were fed a high-fat and high-fructose (HFHF) diet for 16 wk. HFHF-fed KO mice had increased hepatic steatosis and inflammation and aggravated glucose intolerance and insulin resistance compared with wild-type mice...
May 23, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28535237/effect-of-intravenous-ferric-carboxymaltose-on-hemoglobin-response-among-patients-with-acute-isovolemic-anemia-following-gastrectomy-the-fairy-randomized-clinical-trial
#18
Young-Woo Kim, Jae-Moon Bae, Young-Kyu Park, Han-Kwang Yang, Wansik Yu, Jeong Hwan Yook, Sung Hoon Noh, Mira Han, Keun Won Ryu, Tae Sung Sohn, Hyuk-Joon Lee, Oh Kyoung Kwon, Seung Yeob Ryu, Jun-Ho Lee, Sung Kim, Hong Man Yoon, Bang Wool Eom, Min-Gew Choi, Beom Su Kim, Oh Jeong, Yun-Suhk Suh, Moon-Won Yoo, In Seob Lee, Mi Ran Jung, Ji Yeong An, Hyoung-Il Kim, Youngsook Kim, Hannah Yang, Byung-Ho Nam
Importance: Acute isovolemic anemia occurs when blood loss is replaced with fluid. It is often observed after surgery and negatively influences short-term and long-term outcomes. Objective: To evaluate the efficacy and safety of ferric carboxymaltose to treat acute isovolemic anemia following gastrectomy. Design, Setting, and Participants: The FAIRY trial was a patient-blinded, randomized, phase 3, placebo-controlled, 12-week study conducted between February 4, 2013, and December 15, 2015, in 7 centers across the Republic of Korea...
May 23, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28535061/sitting-phase-monolayers-of-polymerizable-phospholipids-create-dimensional-molecular-scale-wetting-control-for-scalable-solution-based-patterning-of-layered-materials
#19
Shi Wah Choong, Shane R Russell, Jae Jin Bang, Justin K Patterson, Shelley A Claridge
The use of dimensionally ordered ligands on layered materials to direct local electronic structure and interactions with the environment promises to streamline integration into nanostructured electronic, optoelectronic, sensing, and nanofluidic interfaces. Substantial progress has been made in using ligands to control substrate electronic structure. Conversely, using the exposed face of the ligand layer to structure wetting and binding interactions, particularly with scalable solution- or spray-processed materials, remains a significant challenge...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28534567/intrinsic-ferromagnetism-and-quantum-anomalous-hall-effect-in-a-cobr2-monolayer
#20
Peng Chen, Jin-Yu Zou, Bang-Gui Liu
The electronic, magnetic, and topological properties of a CoBr2 monolayer are studied in the framework of density-functional theory (DFT) combined with tight-binding (TB) modeling in terms of the Wannier basis. Our DFT investigation and Monte Carlo simulation show that there exists intrinsic two-dimensional ferromagnetism in the CoBr2 monolayer, thanks to the large out-of-plane magnetocrystalline anisotropic energy. Our further study indicates that the spin-orbit coupling makes it become a topologically nontrivial insulator with a quantum anomalous Hall effect and topological Chern number [script C] = 4 and its edge states can be manipulated by changing the width of its nanoribbons and applying strains...
May 23, 2017: Physical Chemistry Chemical Physics: PCCP
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