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https://www.readbyqxmd.com/read/29467588/pulmonary-arterial-enlargement-is-associated-with-acute-chest-pain-in-patients-without-obstructive-coronary-artery-disease
#1
Narasa Madam, Wassim Mosleh, Natdanai Punnanithinont, Andres Carmona-Rubio, Zaid H Said, Umesh C Sharma
Background: Pulmonary hypertension (PH) is an underdiagnosed cause for chest pain in patients without significant coronary artery disease (CAD). Studies showed that enlarged pulmonary arterial (PA) and right ventricular chamber sizes correlate with the severity of PH. Therefore, we studied the association between chest pain, right ventricular dimensions (RVDs), and PA size on coronary coronary tomographic angiography (CCTA). Methods: The CCTA of 87 patients presenting with chest pain without evidence of obstructive CAD was examined...
2018: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
https://www.readbyqxmd.com/read/29467409/combined-use-of-cemip-and-ca-19-9-enhances-diagnostic-accuracy-for-pancreatic-cancer
#2
Hee Seung Lee, Chan Young Jang, Sun A Kim, Soo Been Park, Dawoon E Jung, Bo Ok Kim, Ha Yan Kim, Moon Jae Chung, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Si Young Song
Carbohydrate antigen (CA) 19-9 is the only diagnostic marker used in pancreatic cancer despite its limitations. Here, we aimed to identify the diagnostic role of CEMIP (also called KIAA1199) combined with CA 19-9 in patients with pancreatic cancer. A retrospective analysis of prospectively collected patient samples was performed to determine the benefit of diagnostic markers in the diagnosis of pancreatic cancer. We investigated CEMIP and CA 19-9 levels in 324 patients with pancreatic cancer and 49 normal controls using serum enzyme-linked immunosorbent assay...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29464019/the-involvement-of-serum-exosomal-mir-500-3p-and-mir-770-3p-in-aging-modulation-by-calorie-restriction
#3
Eun Kyeong Lee, Hyoung Oh Jeong, Eun Jin Bang, Chul Hong Kim, Ji Young Mun, Seulgi Noh, Jeong-An Gim, Dae Hyun Kim, Ki Wung Chung, Byung Pal Yu, Hae Young Chung
Recent studies have shown a role for miRNAs in aging and age-related diseases, and the modulation of miRNA expression by diet attracts attention as a new therapeutic strategy. Here, we focused on identifying specific exosomal miRNAs derived from serum of aged rats and the effect of short-term calorie restriction (CR) on their expression. Exosomes from serum of young (7-month), old (22-month), and old-CR Sprague Dawley rats were isolated and characterized by transmission electron microscopy analyses, dynamic light scattering measurements, and Western blotting...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29463869/angiotensin-converting-enzyme-inhibitor-reduces-scar-formation-by-inhibiting-both-canonical-and-noncanonical-tgf-%C3%AE-1-pathways
#4
Qing-Qing Fang, Xiao-Feng Wang, Wan-Yi Zhao, Shi-Li Ding, Bang-Hui Shi, Ying Xia, Hu Yang, Li-Hong Wu, Cai-Yun Li, Wei-Qiang Tan
Angiotensin-converting enzyme inhibitors (ACEIs) can improve the fibrotic processes in many internal organs. Recent studies have shown a relationship between ACEI with cutaneous scar formation, although it has not been confirmed, and the underlying mechanism is unclear. In this study, we cultured mouse NIH 3T3 fibroblasts with different concentrations of ACEI. We measured cell proliferation with a Cell Counting Kit-8 and collagen expression with a Sirius Red Collagen Detection Kit. Flow cytometry and western blotting were used to detect transforming growth factor β1 (TGF-β1) signaling...
February 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29463783/comparison-of-percutaneous-kyphoplasty-and-bone-cement-augmented-short-segment-pedicle-screw-fixation-for-management-of-k%C3%A3-mmell-disease
#5
Yan-Sheng Huang, Ding-Jun Hao, Hang Feng, Hai-Ping Zhang, Si-Min He, Chao-Yuan Ge, Xing-Bang Niu
BACKGROUND The purpose of this study was to compare the efficacy of percutaneous kyphoplasty (PKP) and bone cement-augmented short segmental fixation (BCA+SSF) for treating Kümmell disease. MATERIAL AND METHODS Between June 2013 and December 2015, 60 patients were treated with PKP or BCA+SSF. All patients were followed up for 12-36 months. We retrospectively reviewed outcomes, including Oswestry Disability Index (ODI), visual analogue scale (VAS), and kyphotic Cobb angle. RESULTS VAS, ODI, and Cobb angle, measured postoperatively and at the final follow-up, were lower than those measured preoperatively in both groups (P<0...
February 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29461689/clinical-associations-between-allergies-and-rapid-eye-movement-sleep-disturbances
#6
Shelley R Berson, Jaclyn Klimczak, Elizabeth A Prezio, Shirley Hu, Manoj Abraham
BACKGROUND: Allergic rhinitis, an immunoglobulin E inflammatory condition including nasal congestion, obstruction, sneezing, pruritus, and fatigue symptoms, has significant impact on quality of life and impairs sleep. Sleep-disordered breathing (SDB) patients often have normal all-night apnea-hypopnea (AHI) or respiratory-disturbance (RDI) indices on polysomnography (PSG). We hypothesized that the rapid eye motion-respiratory disturbance index (REM-RDI) may be a novel predictor of allergic status...
February 20, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29458541/direct-rapid-antibiotic-susceptibility-test-drast-for-blood-culture-and-its-potential-usefulness-in-clinical-practice
#7
Jeong-Han Kim, Taek Soo Kim, Sang Hoon Song, Jungil Choi, Sangkwon Han, Dong Young Kim, Sunghoon Kwon, Eunyoung Lee, Kyoung-Ho Song, Pyeong Gyun Choe, Ji Hwan Bang, Eu Suk Kim, Sang Won Park, Hong Bin Kim, Nam Joong Kim, Wan Beom Park, Myoung-Don Oh
PURPOSE: The direct rapid antibiotic susceptibility test (dRAST), based on analysing changes in bacterial micro-colonies under antibiotic conditions, detects antibiotic resistance within 6 h of direct smear examination results. This study aimed to assess the accuracy of dRAST and evaluate its potential usefulness for improving selection of appropriate antibiotic in real clinical practice settings. METHODOLOGY: We evaluated the accuracy of dRAST by comparing the antibiotic treatments that should have been administered based on dRAST results and the broth microdilution (BMD) test and its potential usefulness via simulation...
January 12, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29458406/assessing-dengue-transmission-risk-and-a-vector-control-intervention-using-entomological-and-immunological-indices-in-thailand-study-protocol-for-a-cluster-randomized-controlled-trial
#8
Hans J Overgaard, Chamsai Pientong, Kesorn Thaewnongiew, Michael J Bangs, Tipaya Ekalaksananan, Sirinart Aromseree, Thipruethai Phanitchat, Supranee Phanthanawiboon, Benedicte Fustec, Vincent Corbel, Dominique Cerqueira, Neal Alexander
BACKGROUND: Dengue fever is the most common and widespread mosquito-borne arboviral disease in the world. There is a compelling need for cost-effective approaches and practical tools that can reliably measure real-time dengue transmission dynamics that enable more accurate and useful predictions of incidence and outbreaks. Sensitive surveillance tools do not exist today, and only a small handful of new control strategies are available. Vector control remains at the forefront for combating dengue transmission...
February 20, 2018: Trials
https://www.readbyqxmd.com/read/29458238/active-contour-configuration-model-for-estimating-the-posterior-ablative-margin-in-image-fusion-of-real-time-ultrasound-and-3d-ultrasound-or-magnetic-resonance-images-for-radiofrequency-ablation-an-experimental-study
#9
Junkyo Lee, Min Woo Lee, Dongil Choi, Dong Ik Cha, Sunyoung Lee, Tae Wook Kang, Jehoon Yang, Jaemoon Jo, Won-Chul Bang, Jongsik Kim, Dongkuk Shin
Purpose: The purpose of this study was to evaluate the accuracy of an active contour model for estimating the posterior ablative margin in images obtained by the fusion of real-time ultrasonography (US) and 3-dimensional (3D) US or magnetic resonance (MR) images of an experimental tumor model for radiofrequency ablation. Methods: Chickpeas (n=12) and bovine rump meat (n=12) were used as an experimental tumor model. Grayscale 3D US and T1-weighted MR images were pre-acquired for use as reference datasets...
December 21, 2017: Ultrasonography
https://www.readbyqxmd.com/read/29457931/synthesis-and-characterization-of-nanodiamond-growth-factor-complexes-towards-applications-in-oral-implantation-and-regenerative-medicine
#10
Julie Bang, Caleb Ting, Peter Wang, Ted Kim, Kenneth Wang, Theodore Kee, Darron Miya, Dean Ho, Dong-Keun Lee
Current challenges in the field of regenerative medicine include the need to deliver sustained concentrations of growth factors and genes that are required to induce the repair of deficient tissues. Enhancement of drug delivery and uptake may result in improved growth factor efficacy. Nanodiamonds (NDs) were explored as potential growth factor delivery agents due to the many favorable properties that they possess. For example, ND's biocompatibility has been extensively validated pre-clinically. In addition, they can be scalably produced through impact events such as detonation...
February 19, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29457419/-treatment-of-scapular-fractures-with-lateral-incision-and-bridge-combined-internal-fixation-system
#11
Yu-Cheng Zhou, Lin-Xin Yu, Hong Duan, Jie Min, Xiao-Feng Yuan, Peng Yu, Bang-Xu Nie, Jun Hu
OBJECTIVE: To investigate the clinical results of scapula fractures with lateral incision combined with bridge internal fixation system. METHODS: From October 2012 to December 2016, 20 cases of scapular fractures were treated through the lateral incision combined with bridge fixation system, including 15 males and 5 females, with an average age of 31.6 years old(ranged, 21 to 52 years old). Fourteen cases were scapular body fracture, 10 were scapular neck fracture, 6 were scapular fracture, 1 was acromion fracture, 1 was coracoid fracture, 4 were the glenoid rim fracture, 3 were the glenoid fossa fracture...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457175/tetrabenzo-chichibabin-s-hydrocarbons-substituent-effects-and-unusual-thermochromic-and-thermomagnetic-behaviours
#12
Chuanling Jiang, Yawen Bang, Xinhao Wang, Xuefeng Lu, Zhenglong Lim, Haipeng Wei, Samir El-Hankari, Jishan Wu, Zebing Zeng
Open-shell π-conjugated compounds have recently received intense attention due to their unique properties and promising applications in materials science. However, the experiments on how the substituents affect their chemical bonding and structural motif remain less addressed. In this work, a series of tetrabenzo-Chichibabin's hydrocarbon (TBC) derivatives substituted by different electron-donating or -withdrawing groups at the termini were synthesized. The substituent effect was studied via X-ray crystallographic analysis...
February 19, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29455489/-causes-prevention-and-treatment-for-cerebrospinal-leak-after-lumbar-revision-surgery
#13
Yan-Sheng Huang, Hai-Ping Zhang, Xing-Bang Niu, Shao-Yan Shi, Ding-Jun Hao
OBJECTIVE: To analyze the causes and explore the measures of prevention and treatment of the cerebrospinal leak after lumbar revision surgery. METHODS: The clinical data of 24 patients(17.78%) with cerebrospinal leak among 135 cases after lumbar revision surgery from January 2011 to January 2016 was retrospectively studied. Of them, 12 cases due to severe adhesion caused by scar formation; 4 cases due to yellow ligament hyperplasia adhesion with dura mater occurred dural tears when separating adhesion; 2 cases with severe hyperplasia and ossification of lumbar posterior longitudinal ligament occurred dural tears when revealing intervertebral disk; 2 cases due to improper nailing happened dural tears during operation...
September 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29453393/adherence-to-antiretroviral-therapy-and-factors-affecting-low-medication-adherence-among-incident-hiv-infected-individuals-during-2009-2016-a-nationwide-study
#14
Jungmee Kim, Eunyoung Lee, Byung-Joo Park, Ji Hwan Bang, Jin Yong Lee
For ideal clinical benefit, human immunodeficiency virus (HIV)-infected individuals should receive continuous medication. This is the first nationwide antiretroviral therapy (ART) adherence study in Asia, where medication monitoring at national level is systemically available. We estimated the ART adherence of incident HIV-infected individuals and investigated factors affecting low medication adherence using the national health insurance (NHI) claims data from 2007 to 2016. Medication possession ratio (MPR) was used to measure medication adherence and risk factors were identified by multivariable logistic regression analysis...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29451186/-lactobacillus-acidophilus-and-bifidobacterium-longum-supernatants-upregulate-the-serotonin-transporter-expression-in-intestinal-epithelial-cells
#15
Ya-Nan Cao, Li-Juan Feng, Bang-Mao Wang, Kui Jiang, Shu Li, Xin Xu, Wei-Qiang Wang, Jing-Wen Zhao, Yu-Ming Wang
Background/Aims: Probiotics play a role in relieving irritable bowel syndrome (IBS); however, the underlying mechanism is yet unclear. The aim of the study was to investigate the effects of the supernatants of Lactobacillus acidophilus and Bifidobacterium longum on the expression of serotonin transporter (SERT) messenger ribonucleic acid (mRNA) and protein. Materials and Methods: HT-29 and Caco-2 cells were treated with different concentrations of L. acidophilus and B...
January 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29450849/impaired-arterial-responsiveness-in-untreated-gout-patients-compared-with-healthy-non-gout-controls-association-with-serum-urate-and-c-reactive-protein
#16
Svetlana Krasnokutsky, Aaron Garza Romero, Daisy Bang, Virginia C Pike, Binita Shah, Talia F Igel, Irina Dektiarev, Yu Guo, Judy Zhong, Stuart D Katz, Michael H Pillinger
To determine whether arterial responsiveness is impaired among patients with gout, and whether arterial responsiveness inversely correlates with serum urate and inflammatory measures. This is a cross-sectional study of untreated gout subjects (n = 34) and non-gout healthy controls (n = 64). High-resolution dynamic ultrasound-measured flow-mediated dilation (FMD) and nitroglycerin-mediated dilation (NMD) assessed endothelium-dependent and endothelium-independent arterial responsiveness respectively. Serum urate (sUA) and high-sensitivity C-reactive protein (hsCRP) were measured in the gout group, and correlated with FMD and NMD responses...
February 15, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29449938/molecular-characteristics-and-successful-management-of-a-respiratory-syncytial-virus-outbreak-among-pediatric-patients-with-hemato-oncological-disease
#17
Claas Baier, Sibylle Haid, Andreas Beilken, Astrid Behnert, Martin Wetzke, Richard J P Brown, Corinna Schmitt, Ella Ebadi, Gesine Hansen, Thomas F Schulz, Thomas Pietschmann, Franz-Christoph Bange
Background: Respiratory syncytial virus (RSV) is responsible for upper and lower respiratory tract infection in adults and children. Especially immunocompromised patients are at high risk for a severe course of infection, and mortality is increased. Moreover RSV can spread in healthcare settings and can cause outbreaks. Herein we demonstrate the successful control and characteristics of a RSV outbreak that included 8 patients in our Department of Pediatric Hematology and Oncology. Methods: We performed an epidemiologic investigation and a molecular analysis of the outbreak strains...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29449365/-big-bang-of-b-cell-development-revealed
#18
REVIEW
Cornelis Murre
Earlier studies have identified transcription factors that specify B-cell fate, but the underlying mechanisms remain to be revealed. Two new studies by Miyai and colleagues (pp. 112-126) and Li and colleagues (pp. 96-111) in this issue of Genes & Development provide new and unprecedented insights into the genetic and epigenetic mechanisms that establish B-cell identity.
January 15, 2018: Genes & Development
https://www.readbyqxmd.com/read/29449185/association-of-coffee-consumption-and-non-motor-symptoms-in-drug-na%C3%A3-ve-early-stage-parkinson-s-disease
#19
Bang-Hoon Cho, Seong-Min Choi, Joon-Tae Kim, Byeong C Kim
OBJECTIVE: Coffee consumption has an inverse association with the risk of Parkinson's disease (PD). The aim of this study was to investigate the association between coffee consumption and non-motor symptoms (NMSs) in patients with PD. METHODS: In this cross-sectional study, we included 196 early-stage, treatment-naïve PD patients. Coffee consumption history was obtained via semi-structured interviews. NMSs were assessed using the Non-Motor Symptom assessment scale (NMSS)...
February 9, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29448742/no%C3%A2-gas-sensing-properties-of-nano-sized-wo%C3%A2-powders-prepared-by-a-polyvinyl-alcohol-solution-route
#20
Il-Hwan Bang, Sung-Yong Cho, Mircea Pantilimon, Sang-Jin Lee
Nano-sized tungsten oxide (WO3) powder shows excellent sensitivity as a NOx gas sensor. The tungsten oxide powders synthesized by polyvinyl alcohol (PVA) polymer solution method showed either plates or spheres of tungsten nanoparticles with agglomeration. The size of the particles was about 30 nm and the surface areas of the powders fell in 10.5~21.5 m2/g. For NO2 gas sensing test, the synthesized WO3 powders have been operated under various temperatures and gas concentrations. The response time, recovery time and stability were strongly depended on the powder size and morphology...
March 1, 2018: Journal of Nanoscience and Nanotechnology
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