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https://www.readbyqxmd.com/read/29667921/glycemic-control-of-type-2-diabetes-mellitus-across-stages-of-renal-impairment-information-for-primary-care-providers
#1
Lili Tong, Sharon Adler
Chronic kidney disease (CKD) is a frequent complication of type 2 diabetes mellitus (T2DM) and elevates individuals' risk for cardiovascular disease, the leading cause of morbidity and mortality in T2DM. Achieving and maintaining tight glycemic control is key to preventing development or progression of CKD; however, improving glycemic control may be limited by effects of renal impairment on the efficacy and safety of T2DM treatments, necessitating dosing adjustments and careful evaluation of contraindications...
April 18, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29666613/novel-biocontrol-methods-for-listeria-monocytogenes-biofilms-in-food-production-facilities
#2
REVIEW
Jessica A Gray, P Scott Chandry, Mandeep Kaur, Chawalit Kocharunchitt, John P Bowman, Edward M Fox
High mortality and hospitalization rates have seen Listeria monocytogenes as a foodborne pathogen of public health importance for many years and of particular concern for high-risk population groups. Food manufactures face an ongoing challenge in preventing the entry of L. monocytogenes into food production environments (FPEs) due to its ubiquitous nature. In addition to this, the capacity of L. monocytogenes strains to colonize FPEs can lead to repeated identification of L. monocytogenes in FPE surveillance...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29665951/statistical-considerations-for-pediatric-multidrug-resistant-tuberculosis-efficacy-trials
#3
S Kim, J A Seddon, A J Garcia-Prats, G Montepiedra
The inclusion of newly licensed or repurposed drugs in regimens to treat children for multidrug-resistant tuberculosis (TB) may lead to treatment that is shorter than traditional regimens and composed only of oral medications. As an all-oral regimen may be more acceptable and have a better safety profile than current regimens, demonstrating non-inferiority may be satisfactory. Demonstrating non-inferior efficacy requires setting a non-inferiority margin and safeguarding study assay sensitivity. Multi-arm, multistage designs may currently not be appropriate in pediatric trials because of the lack of sensitive and specific intermediate outcomes...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29664827/skin-graft-fixation-using-hydrofiber-aquacel%C3%A2-extra
#4
Ya-Hui Yen, Chih-Ming Lin, Honda Hsu, Ying-Chen Chen, Yi-Wen Chen, Wan-Yu Li, Chia-Nan Hsieh, Chieh-Chi Huang
BACKGROUND: The traditional method of skin graft fixation is with tie-over bollus dressing. The use of splints in the extremities for skin graft fixation is a common practice. However, these splints are heavy and uncomfortable and contribute considerably to our overall medical waste. Hydrofiber (Aquacel Extra) has a strong fluid absorption property and fixates well to the underlying wound once applied. In this study, we used hydrofiber for fixation, avoiding the use of splints after skin grafting...
April 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29663381/resin-embedded-anatomical-cross-sections-as-a-teaching-adjunct-for-medical-curricula-is-this-technique-an-alternative-to-potting-and-plastination
#5
Fraser Chisholm, Ourania Varsou
With an ever-expanding use of cross-sectional imaging for diagnostic and therapeutic purposes, there has also been an increase in the need for exposure to such radiological and anatomical views at the undergraduate and postgraduate level to allow for early familiarisation with the relevant anatomy. Cadaveric cross-sections offer an excellent link between the two-dimensional radiological images and the three-dimensional anatomical structures. For such cross-sections to be useful and informative within educational settings, they need to be: (i) safe for students and trainees to handle and (ii) robust enough to withstand repeated handling; as well as (iii) displaying anatomy clearly and accurately...
April 16, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29662720/role-of-active-versus-passive-complementary-and-integrative-health-approaches-in-pain-management
#6
David Cosio, Erica Lin
Background: A general conclusion about the treatment of chronic, noncancer pain is that the results from traditional, passive modalities are disheartening. Perhaps this may be due to the propensity of patients to seek out passive versus active treatments. In pain management, active treatments should be the primary focus, with passive interventions as an adjunct. Objective: The current study tested the hypotheses that Veterans would report a greater significant increase in active versus transitional and active versus passive complementary and integrative health (CIH) utilization after completing a formal pain education program...
2018: Global Advances in Health and Medicine: Improving Healthcare Outcomes Worldwide
https://www.readbyqxmd.com/read/29661381/a-review-of-the-safety-and-efficacy-of-inhaled-methoxyflurane-as-an-analgesic-for-outpatient-procedures
#7
REVIEW
C Jephcott, J Grummet, N Nguyen, O Spruyt
Methoxyflurane delivered via a hand-held inhaler is a proven analgesic which has been used in Australasia for emergency relief of trauma associated pain since the 1970s. The agent is self-administered by the patient under the supervision of trained personnel. More than 5 million patients have received inhaled methoxyflurane without significant side effects. Methoxyflurane is also licensed in Australasia for the relief of pain in monitored conscious patients requiring analgesia for minor surgical procedures...
May 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29661191/factors-associated-with-treatment-seeking-for-malaria-in-urban-poor-communities-in-accra-ghana
#8
Raphael Baffour Awuah, Paapa Yaw Asante, Lionel Sakyi, Adriana A E Biney, Mawuli Komla Kushitor, Francis Agyei, Ama de-Graft Aikins
BACKGROUND: In Ghana, about 3.5 million cases of malaria are recorded each year. Urban poor residents particularly have a higher risk of malaria mainly due to poor housing, low socio-economic status and poor sanitation. Alternative treatment for malaria (mainly African traditional/herbal and/or self-medication) is further compounding efforts to control the incidence of malaria in urban poor communities. This study assesses factors associated with seeking alternative treatment as the first response to malaria, relative to orthodox treatment in three urban poor communities in Accra, Ghana...
April 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29660583/aie-based-superwettable-microchips-for-evaporation-and-aggregation-induced-fluorescence-enhancement-biosensing
#9
Yanxia Chen, Xuehong Min, Xiqi Zhang, Feilong Zhang, Simeng Lu, Li-Ping Xu, Xiaoding Lou, Fan Xia, Xueji Zhang, Shutao Wang
Superwettable microchips with superhydrophilic microwells on superhydrophobic substrate have attracted increasing attention in fluorescence-based biological and medical diagnostics. However, traditional fluorophores often suffer from the aggregation-caused quenching (ACQ) problem at high concentration or in aggregated state. Here, we developed an AIE-based superwettable microchip by combining the evaporation-induced enrichment of superwettable microchips and the aggregation-induced emission of AIEgens together into one chip...
April 7, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29659788/the-burden-and-benefits-of-caregiving-a-latent-class-analysis
#10
Teja Pristavec
Background and Objectives: Informal caregiving to older adults is a key part of the U.S. long-term care system. Caregivers' experiences consist of burden and benefits, but traditional analytic approaches typically consider dimensions independently, or cannot account for burden and benefit levels and combinations that co-occur. This study explores how benefits and burden simultaneously shape experiences of caregiving to older adults, and factors associated with experience types. Research Design and Methods: 2015 National Health and Aging Trends Study (NHATS) and National Study of Caregiving (NSOC) data were linked to obtain reports from caregivers and recipients...
April 6, 2018: Gerontologist
https://www.readbyqxmd.com/read/29659375/validity-reliability-feasibility-and-usefulness-of-pain-monitor-a-multidimensional-smartphone-app-for-daily-monitoring-of-adults-with-heterogeneous-chronic-pain
#11
Carlos Suso-Ribera, Diana Castilla, Irene Zaragozá, María Victoria Ribera-Canudas, Cristina Botella, Azucena García-Palacios
OBJECTIVES: Ecological momentary assessment is recommended in the management of chronic pain. Smartphone apps might be a useful tool for that purpose. This study goal was to develop and test a multidimensional smartphone app for adults with chronic pain. A multidisciplinary team developed app content after a series of meetings, considering clinical guidelines for pain measurement. Content included pain intensity and interference, fatigue, mood, perceived health status, activity level, side effects of the medication, use of rescue medication, and pain-related psychological constructs (catastrophizing, acceptance, fear, and coping)...
April 13, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29658435/combined-immunotherapy-ok-432-il-2-with-chemotherapy-decrease-the-recurrence-rate-in-advanced-ovarian-cancer
#12
Yi-Lun Wang, Hsiu-Huei Peng, Sheng-Yuan Su, Cheng-Tao Lin
OBJECTIVE: In advanced ovarian cancer, traditional therapy included debulking surgery and postoperative chemotherapy. We proposed immunochemotherapy (IMCT) combined with picibanil (OK-432), interleukin-2 (IL-2), and traditional platinum- and taxol-based chemotherapy as a better treatment option for advanced ovarian cancer. METHODS: We retrospectively reviewed the medical records of 51 patients with advanced ovarian cancer between 2007 and 2015 at Chang Gung Memorial Hospital Linkou Medical Center, including 26 patients who were treated with OK-432, IL-2, and platinum- and taxol-based chemotherapy (IMCT group) after debulking surgery; another 25 were treated with traditional platinum- and taxol-based chemotherapy (traditional chemotherapy group) after debulking surgery...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29658388/prostate-cancer-screening-perception-beliefs-and-practices-among-men-in-bamenda-cameroon
#13
Ernest Kaninjing, Ivette Lopez, Jennifer Nguyen, Folakemi Odedina, Mary Ellen Young
Prostate Cancer (CaP) is the most commonly diagnosed cancer among Cameroonian men. Due to inadequate infrastructure, record keeping, and resources, little is known about its true burden on the population. There are rural/urban disparities with regards to awareness, screening, treatment, and survivorship. Furthermore, use of traditional medicine and homeopathic remedies is widespread, and some men delay seeking conventional medical treatment until advanced stages of CaP. This study examined the perceptions, beliefs, and practices of men in Cameroon regarding late stage CaP diagnoses; identified factors that influence screening decision; and ascertained how men decided between traditional or conventional medicine for CaP diagnosis and treatment...
April 1, 2018: American Journal of Men's Health
https://www.readbyqxmd.com/read/29657247/protective-effect-of-taohong-siwu-decoction-on-abnormal-uterine-bleeding-induced-by-incomplete-medical-abortion-in-rats-during-early-pregnancy
#14
Yanyan Zhang, Jichen Wang, Chijing Zuo, Weidong Chen, Qian Zhu, Dongdong Guo, Huanru Wu, Huizhuo Wang, Daiyin Peng, Lan Han
Abnormal uterine bleeding (AUB) induced by incomplete abortion is a common gynecological disease. Taohong Siwu decoction (TSD) is a traditional Chinese medicine (TCM) formula, which has been developed to treat AUB for hundreds of years. In this study, rats had incomplete abortion induced in early pregnancy using mifepristone and misoprostol. The duration and quantity of uterine bleeding were recorded and measured. The pathologic histologic grade was evaluated by hematoxylin-eosin staining (HE). Estradiol (E2 ) and progesterone (P) levels were measured by enzyme linked immunosorbent assays (ELISA)...
April 14, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29656800/dopaminergic-disturbances-in-tourette-syndrome-an-integrative-account
#15
REVIEW
Tiago V Maia, Vasco A Conceição
Tourette syndrome (TS) is thought to involve dopaminergic disturbances, but the nature of those disturbances remains controversial. Existing hypotheses suggest that TS involves 1) supersensitive dopamine receptors, 2) overactive dopamine transporters that cause low tonic but high phasic dopamine, 3) presynaptic dysfunction in dopamine neurons, or 4) dopaminergic hyperinnervation. We review evidence that contradicts the first two hypotheses; we also note that the last two hypotheses have traditionally been considered too narrowly, explaining only small subsets of findings...
March 9, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29656758/feasibility-of-endobronchial-ultrasound-transbronchial-needle-aspiration-for-massively-parallel-next-generation-sequencing-in-thoracic-cancer-patients
#16
Simon R Turner, Darren Buonocore, Patrice Desmeules, Natasha Rekhtman, Snjezana Dogan, Oscar Lin, Maria E Arcila, David R Jones, James Huang
INTRODUCTION: Next-generation sequencing (NGS) allows for the identification of a growing number of therapeutic and prognostic molecular targets. However, NGS typically requires greater quantities of DNA than traditional molecular testing does. Endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure used to sample central thoracic lesions, but it is not well established whether this technique provides sufficient material for NGS. METHODS: We performed a retrospective review of EBUS-TBNA at our institution (3/1/14-9/28/16)...
May 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29656726/the-mental-health-consumer-movement-and-peer-providers-in-israel
#17
G S Moran
Self-help peer-support groups in Israel emerged in the 1980s and, over time, dynamically interacted and co-developed with the statutory mental health (MH) system. In this editorial, I outline historical milestones of how the evolution of the Israeli mental health system was influenced by the consumer movement. A brief depiction of the consumer movement history. At first, consumers operated outside of the mainstream MH system. Gradually, consumer groups and institutional personnel joined efforts towards community integration and enhancement of quality of life, pushing forward a person-centered recovery orientation...
April 16, 2018: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/29655947/co-occurrence-of-medical-conditions-exposing-patterns-through-probabilistic-topic-modeling-of-snomed-codes
#18
Moumita Bhattacharya, Claudine Jurkovitz, Hagit Shatkay
Patients associated with multiple co-occurring health conditions often face aggravated complications and less favorable outcomes. Co-occurring conditions are especially prevalent among individuals suffering from kidney disease, an increasingly widespread condition affecting 13% of the general population in the US. This study aims to identify and characterize patterns of co-occurring medical conditions in patients employing a probabilistic framework. Specifically, we apply topic modeling in a non-traditional way to find associations across SNOMED-CT codes assigned and recorded in the EHRs of >13,000 patients diagnosed with kidney disease...
April 12, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29655558/effects-of-feeding-milk-replacer-at-2-rates-with-pelleted-low-starch-or-texturized-high-starch-starters-on-calf-performance-and-digestion
#19
J D Quigley, T M Hill, T S Dennis, F X Suarez-Mena, R L Schlotterbeck
Milk replacer (MR) feeding programs have traditionally fed at less than ad libitum amounts to promote calf starter (CS) intake and allow early weaning. More recently, increased amounts of MR preweaning have been shown to increase preweaning ADG, although postweaning growth may be reduced. Several studies suggest that limited postweaning digestion of nutrients in CS may contribute to postweaning growth impairment. It is not clear whether CS formulation might also contribute to differences in postweaning nutrient digestion when calves are fed different MR programs...
April 11, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29655480/nontraditional-therapies-traditional-chinese-veterinary-medicine-and-chiropractic-in-exotic-animals
#20
REVIEW
Jessica A Marziani
The nontraditional therapies of Traditional Chinese Veterinary Medicine and chiropractic care are adjunct treatments that can be used in conjunction with more conventional therapies to treat a variety of medical conditions. Nontraditional therapies do not need to be alternatives to Western medicine but, instead, can be used simultaneously. Exotic animal practitioners should have a basic understanding of nontraditional therapies for both client education and patient referral because they can enhance the quality of life, longevity, and positive outcomes for various cases across multiple taxa...
May 2018: Veterinary Clinics of North America. Exotic Animal Practice
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