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https://www.readbyqxmd.com/read/27926975/large-for-gestational-age-infants-and-adverse-outcomes-among-uncomplicated-pregnancies-at-term
#1
Hector Mendez-Figueroa, Van Thi Thanh Truong, Claudia Pedroza, Suneet P Chauhan
Background While traumatic delivery with large for gestational age (LGA; birth weight above 90%) is acknowledged, there is paucity of data regarding other morbidity and mortality associated with LGA. Our hypothesis was that compared with appropriate for gestational age (AGA), LGA have a significantly higher rate of composite neonatal morbidity (CNM). Objective Our objective was to compare the CNM among uncomplicated LGA versus AGA at term (37 weeks or more) among all available Maternal-Fetal Medicine Units (MFMU) databases...
December 7, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27926974/pregnant-patient-knowledge-and-behavior-regarding-perinatal-oral-health
#2
Bernard Gonik, Eline Wilson, Melanie Mayberry, Bushra Yuki Joarder
Objective Perinatal oral health is important to obstetric practice, with significant implications for maternal, fetal, and infant health. This study sought to describe and compare knowledge and behavior related to perinatal oral health in two distinct populations of pregnant women. Methods An anonymous 13-question survey was distributed at two patient centers (urban teaching clinics and suburban referral center), examining patient knowledge and behaviors pertaining to oral health. Descriptive statistics were tabulated...
December 7, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27926973/neurologic-injury-in-acidemic-term-infants
#3
Alison G Cahill, Amit M Mathur, Christopher D Smyser, Robert C Mckinstry, Kimberly A Roehl, Julia D López, Terrie E Inder, George A Macones
Objective To determine whether arterial umbilical cord gas (aUCG) pH, in anatomically normal-term infants, could select infants at risk for brain injury identified on magnetic resonance imaging (MRI). Study Design We performed a nested case-control within a prospective cohort of 8,580 women. Cases, with an aUCG pH < 7.10, were temporally, age, and sex matched to controls with an aUCG pH ≥ 7.20. Bi- and multivariable analyses compared the presence and severity of brain injury. Secondary analyses estimated whether elevated arterial base excess or lactate were associated with brain injury...
December 7, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27926920/infants-looking-to-surprising-events-when-eye-tracking-reveals-more-than-looking-time
#4
H Henny Yeung, Stephanie Denison, Scott P Johnson
Research on infants' reasoning abilities often rely on looking times, which are longer to surprising and unexpected visual scenes compared to unsurprising and expected ones. Few researchers have examined more precise visual scanning patterns in these scenes, and so, here, we recorded 8- to 11-month-olds' gaze with an eye tracker as we presented a sampling event whose outcome was either surprising, neutral, or unsurprising: A red (or yellow) ball was drawn from one of three visible containers populated 0%, 50%, or 100% with identically colored balls...
2016: PloS One
https://www.readbyqxmd.com/read/27926598/acculturation-and-postpartum-depressive-symptoms-among-hispanic-women-in-the-united-states-systematic-review
#5
Dalia Alhasanat, Carmen Giurgescu
PURPOSE: The purpose of this review was to evaluate studies that examined the relationship between acculturation and postpartum depression (PPD) among immigrant and/or refugee women in the United States. METHODS: A systematic, computer-assisted search of quantitative, English-language, peer-reviewed, published research articles was conducted in the Scopus, PsycINFO, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Maternity and Infant Care databases using the keyword terms of "postpartum depression" and "perinatal depression" in combination with "acculturation...
January 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/27926583/evaluation-of-the-financial-and-health-burden-of-infants-at-risk-for-respiratory-syncytial-virus
#6
Stephanie McCallum Blake, David Tanaka, Lisa M Bendz, Suzanne Staebler, Debra Brandon
BACKGROUND: Respiratory syncytial virus (RSV) is the leading viral cause of death in infants younger than 1 year. In July 2014, the American Academy of Pediatrics (AAP) Committee on Infectious Diseases concluded that the "limited clinical benefit" for infants born at more than 29 weeks' gestation, together with the associated high cost of the immunoprophylaxis, no longer supported the routine use of palivizumab (Synagis). PURPOSE: To evaluate the impact of the newly adopted AAP palivizumab prophylaxis administration on health and subsequent hospital costs of infants born between 29 and less than 32 weeks' gestation...
December 6, 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/27926522/il-10-expression-defines-an-immunosuppressive-dendritic-cell-population-induced-by-antitumor-therapeutic-vaccination
#7
Diana Llopiz, Marta Ruiz, Stefany Infante, Lorea Villanueva, Leyre Silva, Sandra Hervas-Stubbs, Diego Alignani, Elizabeth Guruceaga, Juan J Lasarte, Pablo Sarobe
Vaccination induces immunostimulatory signals that are often accompanied by regulatory mechanisms such as IL-10, which control T-cell activation and inhibit vaccine-dependent antitumor therapeutic effect. Here we characterized IL-10-producing cells in different tumor models treated with therapeutic vaccines. Although several cell subsets produced IL-10 irrespective of treatment, an early vaccine-dependent induction of IL-10 was detected in dendritic cells (DC). IL-10 production defined a DC population characterized by a poorly mature phenotype, lower expression of T-cell stimulating molecules and upregulation of PD-L1...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27926352/3d-laparoscopy-in-neonates-and-infants
#8
Yury Kozlov, Konstantin Kovalkov, Vladimir Nowogilov
BACKGROUND: This study focuses on the successful application of three-dimensional (3D) laparoscopic surgeries in the treatment of congenital anomalies and acquired diseases in the young pediatric population. The purpose of this scientific work consists in highlighting the spectrum, indications, applicability, and effectiveness of 3D endosurgery in children. METHODS: Our experience is based on 110 endosurgical procedures performed in neonates and infants in the 3D format between January 2014 and May 2015...
December 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27925865/public-health-messages-about-perinatal-marijuana-use-in-an-evolving-policy-context
#9
Marian Jarlenski, Jennifer Zank, Jill Tarr, Judy C Chang
BACKGROUND: Marijuana is a commonly used substance in pregnancy in the U.S. It is unknown what public health messages about perinatal marijuana use are being disseminated in the changing policy landscape. METHODS: We systematically searched 51 state and 5 federal public health agencies' websites in February 2016 for information about perinatal marijuana use. Of these, one federal agency and 10 state agencies had published information about perinatal marijuana use...
December 7, 2016: Substance Abuse
https://www.readbyqxmd.com/read/27925691/parents-need-support-to-find-ways-to-optimise-their-own-sleep-without-seeing-their-preterm-infant-s-sleeping-patterns-as-a-problem
#10
Ylva Thernström Blomqvist, Kerstin Hedberg Nyqvist, Christine Rubertsson, Eva-Lotta Funkquist
AIM: This study described how parents perceived their own sleep, and their infants', during neonatal intensive care unit (NICU) admission and after discharge. It also explored the infants' sleeping location at home. METHODS: The study was conducted in the NICUs of two Swedish university hospitals. The parents of 86 infants - 86 mothers and 84 fathers - answered questionnaires during their infants' hospital stay, at discharge and at the infants' corrected ages of two, six and 12 months...
November 7, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27925643/primary-and-secondary-hemophagocytic-lymphohistiocytosis-have-different-patterns-of-t-cell-activation-differentiation-and-repertoire
#11
Sandra Ammann, Kai Lehmberg, Udo Zur Stadt, Gritta Janka, Anne Rensing-Ehl, Christian Klemann, Maximilian Heeg, Sebastian Bode, Ilka Fuchs, Stephan Ehl
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening inflammatory syndrome characterized by hyperactivation of lymphocytes and histiocytes. T cells play a key role in HLH pathogenesis, but their differentiation pattern is not well characterized in patients with active HLH. We compared T-cell activation patterns between patients with familial HLH (1°HLH), 2°HLH without apparent infectious trigger (2°HLH) and 2°HLH induced by a viral infection (2°V-HLH). Polyclonal CD8(+) T cells are highly activated in 1°HLH and 2°V-HLH, but less in 2°HLH as assessed by HLA-DR expression and marker combination with CD45RA, CCR7, CD127, PD-1 and CD57...
December 7, 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27925622/relation-between-amniotic-fluid-infection-or-cytokine-levels-and-hearing-screen-failure-in-infants-at-32-wk-gestation-or-less
#12
Eun Young Jung, Byung Yoon Choi, Jihye Rhee, Jaehong Park, Soo-Hyun Cho, Kyo Hoon Park
BACKGROUND: To determine whether the presence of intra-amniotic infection and elevated proinflammatory cytokine levels in amniotic fluid (AF) are associated with failure in the newborn hearing screen (NHS) test in very preterm neonates. METHODS: This is a retrospective cohort study of 112 premature singleton neonates born to women with preterm labor or preterm premature rupture of membranes at ≤32 wk. AF obtained through amniocentesis was cultured, and interleukin-6 (IL-6) and IL-8 levels were determined...
December 7, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27925621/presepsin-for-the-detection-of-early-onset-sepsis-in-preterm-newborns
#13
Paolo Montaldo, Roberto Rosso, Alfredo Santantonio, Giovanni Chello, Paolo Giliberti
BACKGROUND: Early-onset sepsis (EOS) is responsible for an important fraction of neonatal morbidity and mortality all over the world. The aim of this study was to assess whether presepsin (P-SEP) can be a more accurate biomarker of EOS compared with pro-calcitonin (PCT) and C-reactive protein (CRP). STUDY DESIGN: Consecutive preterm neonates (<34 wk gestational age, admitted to Neonatal Intensive Care Unit by 6 h of age and undergoing sepsis evaluation) were recruited as part of a case-matched control study...
December 7, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27925619/moderate-hyperoxia-induces-extracellular-matrix-remodeling-by-human-fetal-airway-smooth-muscle-cells
#14
Elizabeth R Vogel, Rodney D Britt, Arij Faksh, Ine Kuipers, Hitesh Pandya, Y S Prakash, Richard J Martin, Christina M Pabelick
BACKGROUND: Premature infants are at increased risk for airway diseases, such as wheezing and asthma, because of early exposure to risk factors including hyperoxia. As in adult asthma, airway remodeling and increased extracellular matrix (ECM) deposition is involved. METHODS: We assessed the impact of 24-72 h of moderate hyperoxia (50%) on human fetal airway smooth muscle (fASM) ECM deposition through western blot, modified in-cell western, and zymography techniques...
December 7, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27925447/rehospitalization-of-preterm-infants-according-to-the-discharge-risk-level
#15
Burcu Aykanat Girgin, Güler Cimete
PURPOSE: The rehospitalization rate of preterm infants is between 22 and 52% within the first year after discharge. The purpose of this study was to investigate the rehospitalization of preterm infants within 2 months following discharge, considering the level of risks originating from the infant, parents, and the social factors. DESIGN AND METHODS: The sample was composed of 238 preterm infants and their parents. The data were collected with a Descriptive Information Form, the Post-Discharge Infant Follow-up Form, and the Neonatal Discharge Assessment Tool (N-DAT)...
December 7, 2016: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/27925172/effect-of-early-intervention-in-infants-at-very-high-risk-of-cerebral-palsy-a-systematic-review
#16
REVIEW
Mijna Hadders-Algra, Anke G Boxum, Tjitske Hielkema, Elisa G Hamer
AIM: First, to systematically review the evidence on the effect of intervention applied during the first postnatal year in infants with or at very high risk of cerebral palsy (CP) on child and family outcome. Second, to assess whether type and dosing of intervention modify the effect of intervention. METHOD: Relevant literature was identified by searching the PubMed, Embase, and CINAHL databases. Selection criteria included infants younger than 12 months corrected age with or at very high risk of CP...
December 7, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27924835/longitudinal-study-of-pesticide-residue-levels-in-human-milk-from-western-australia-during-12-months-of-lactation-exposure-assessment-for-infants
#17
Jian Du, Zoya Gridneva, Melvin C L Gay, Ching T Lai, Robert D Trengove, Peter E Hartmann, Donna T Geddes
The presence of pesticides in human milk (HM) is of great concern due to the potential health effects for the breastfed infant. To determine the relationships between HM pesticides and infant growth and development, a longitudinal study was conducted. HM samples (n = 99) from 16 mothers were collected at 2, 5, 9 and 12 months of lactation. A validated QuEChERS method and Gas chromatography-tandem mass spectrometry (GC-MS/MS) were used for the analysis of 88 pesticides in HM. Only p,p'-DDE, p,p'-DDT and β-HCH were detected with a mean concentration (±SD) of 52...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924741/health-and-health-related-indicators-in-slum-rural-and-urban-communities-a-comparative-analysis
#18
Blessing U Mberu, Tilahun Nigatu Haregu, Catherine Kyobutungi, Alex C Ezeh
BACKGROUND: It is generally assumed that urban slum residents have worse health status when compared with other urban populations, but better health status than their rural counterparts. This belief/assumption is often because of their physical proximity and assumed better access to health care services in urban areas. However, a few recent studies have cast doubt on this belief. Whether slum dwellers are better off, similar to, or worse off as compared with rural and other urban populations remain poorly understood as indicators for slum dwellers are generally hidden in urban averages...
2016: Global Health Action
https://www.readbyqxmd.com/read/27924730/congenital-malformations-attributed-to-prenatal-exposure-to-cyclophosphamide
#19
Padmanabhan Rengasamy
Cyclophosphamide (CPA) remains one of the most widely prescribed anticancer drugs. It is also used in the treatment of rheumatoid arthritis, childhood nephrotic syndrome and systemic lupus erythematosus. It is a potent immunosuppressive agent. It is commonly used in blood and bone marrow transplantation. With the growing trend among women postponing childbearing, the number of women who are diagnosed with breast cancer is also increasing thus escalating the chances of exposure of the unborn child to antineoplastic drugs...
December 6, 2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27924715/perfluoroalkyl-acids-pfaas-and-anthropometric-measures-in-the-first-year-of-life-results-from-the-duisburg-birth-cohort
#20
Eman Alkhalawi, Monika Kasper-Sonnenberg, Michael Wilhelm, Wolfgang Völkel, Jürgen Wittsiepe
In the context of the Duisburg Birth Cohort, this retrospective cohort study provides results of internal exposure to perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), and perfluorohexanesulfonic acid (PFHxS) in 156 mother-child pairs, and investigates whether and to what extent in utero exposure of these chemicals at German background levels exerts an effect on newborn and infant weight and length, and weight in relation to length expressed by ponderal index, in order to examine whether any reduction in weight is disproportionate to length...
2016: Journal of Toxicology and Environmental Health. Part A
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