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https://www.readbyqxmd.com/read/28637335/astrocyte-produced-mir-146a-as-a-mediator-of-motor-neuron-loss-in-spinal-muscular-atrophy
#1
Samantha L Sison, Teresa N Patitucci, Emily R Seminary, Eric Villalon, Christian L Lorson, Allison D Ebert
Spinal muscular atrophy (SMA), the leading genetic cause of infant mortality, is caused by loss of the survival motor neuron-1 (SMN1) gene, which leads to motor neuron loss, muscle atrophy, respiratory distress, and death. Motor neurons exhibit the most profound loss, but the mechanisms underlying disease pathogenesis are not fully understood. Recent evidence suggests that motor neuron extrinsic influences, such as those arising from astrocytes, contribute to motor neuron malfunction and loss. Here we investigated both loss-of-function and toxic gain-of-function astrocyte mechanisms that could play a role in SMA pathology...
June 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28637333/infections-in-early-life-and-development-of-celiac-disease
#2
Andreas Beyerlein, Ewan Donnachie, Anette-Gabriele Ziegler
Early infections have been suggested to be associated with increased risk for later celiac disease (CD). We analyzed prospective claims data of n = 295,420 infants from Bavaria, Germany, born between 2005 and 2007 containing information on medically attended infectious diseases according to ICD-10 code on a quarterly basis to calculate hazard ratios and 95% confidence intervals of time to CD diagnosis by infection exposure, adjusting for sex, calendar month of birth and number of previous healthcare visits...
June 16, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28637062/prospective-comparison-of-enfamil-and-similac-liquid-human-milk-fortifier-on-clinical-outcomes-in-premature-infants
#3
Navin Kumar, Ranjan Monga, Venkatesh Sampath, Barb Ehrhart
No abstract text is available yet for this article.
June 21, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28637056/-urosepsis-in-children
#4
Josef Oswald
Urinary tract infections (UTI) are the most common infectious diseases in children. Urosepsis in childhood, though rare, is the most complicated possible variant. In newborns and infants, unspecific symptoms are a significant barrier to a fast and reliable diagnosis, which is crucial to successful treatment. In addition to urine and laboratory tests as well as non-invasive examinations (ultrasound), there may be an indication for invasive examinations of the kidneys (DMSA scans) in cases of a severe infection...
June 21, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28636872/long-term-postnatal-steroid-effect-in-very-low-birth-weight-infants
#5
YoungAh Youn, Cheong-Jun Moon, In Kyung Sung
We examined whether hydrocortisone exposure ≤ 1week in very low birth weight infants (VLBWI) was associated with poor neurodevelopmental outcomes at corrected 18 months. Further, the clinical factors associated with worse long term outcome were also evaluated. Of a total of 191 VLBWI, the clinical data for these infants relating were retrospectively collected for analysis. Among the 191 VLBWI, 115 (60.2%) infants were exposed to early postnatal hydrocortisone ≤ 1 week of life in our NICU of Seoul St. Mary's Hospital, The Catholic University of Korea between December 2012 and December 2014...
June 18, 2017: Steroids
https://www.readbyqxmd.com/read/28636783/normal-neonatal-hearing-screening-did-not-preclude-sensorineural-hearing-loss-in-two-year-old-very-preterm-infants
#6
Inge L van Noort-van der Spek, André Goedegebure, Nico G Hartwig, René F Kornelisse, Marie-Christine J P Franken, Nynke Weisglas-Kuperus
AIM: Very preterm infants are at risk of neonatal hearing loss. However, it is unknown whether infants with a normal neonatal hearing screening result risk sensorineural hearing loss (SNHL) at a later age. METHODS: This cohort study was conducted at the Erasmus Medical University Center Rotterdam, the Netherlands, on 77 very preterm infants born between October 2005 and September 2008. All infants underwent auditory brainstem response audiometry during neonatal hearing screening and at two years of corrected age...
June 21, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28636674/behavior-change-communication-activities-improve-infant-and-young-child-nutrition-knowledge-and-practice-of-neighboring-non-participants-in-a-cluster-randomized-trial-in-rural-bangladesh
#7
John Hoddinott, Ishita Ahmed, Akhter Ahmed, Shalini Roy
OBJECTIVE: To examine the impact on infant and young child nutrition knowledge and practice of mothers who were neighbors of mothers participating in a nutrition Behavior Change Communication (BCC) intervention in rural Bangladesh. METHODS: We analyzed data from 300 mothers whose neighbor participated in a nutrition BCC intervention and 600 mothers whose neighbor participated in an intervention that did not include BCC. We constructed measures capturing mothers' knowledge of infant and young child nutrition (IYCN) and measures of food consumption by children 6-24m...
2017: PloS One
https://www.readbyqxmd.com/read/28636613/in-vivo-immune-signatures-of-healthy-human-pregnancy-inherently-inflammatory-or-anti-inflammatory
#8
Caroline Graham, Rishma Chooniedass, William P Stefura, Allan B Becker, Malcolm R Sears, Stuart E Turvey, Piush J Mandhane, Padmaja Subbarao, Kent T HayGlass
Changes in maternal innate immunity during healthy human pregnancy are not well understood. Whether basal immune status in vivo is largely unaffected by pregnancy, is constitutively biased towards an inflammatory phenotype (transiently enhancing host defense) or exhibits anti-inflammatory bias (reducing potential responsiveness to the fetus) is unclear. Here, in a longitudinal study of healthy women who gave birth to healthy infants following uncomplicated pregnancies within the Canadian Healthy Infant Longitudinal Development (CHILD) cohort, we test the hypothesis that a progressively altered bias in resting innate immune status develops...
2017: PloS One
https://www.readbyqxmd.com/read/28636462/are-commercial-complementary-food-distributions-to-refugees-and-migrants-in-europe-conforming-to-international-policies-and-guidelines-on-infant-and-young-child-feeding-in-emergencies
#9
Melissa Ann Theurich, Veit Grote
In 2015, more than one million migrants and refugees arrived in Europe. Commercial complementary foods, processed foods marketed for infants and young children 6-23 months of age, were distributed by various humanitarian actors along migrant routes and in European refugee camps. Unsolicited donations and distributions of commercial complementary food products were problematic and divergent from international policies on infant and young child feeding during humanitarian emergencies. Interim guidance regarding commercial complementary foods was published during the peak of the emergency but implemented differently by various humanitarian actors...
June 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28636245/weight-gain-in-the-first-week-of-life-predicts-overweight-at-2%C3%A2-years-a-prospective-cohort-study
#10
Lori Feldman-Winter, Laura Burnham, Xena Grossman, Stephanie Matlak, Ning Chen, Anne Merewood
In formula-fed infants, rapid weight gain during the first week of life is associated with later obesity. To examine the association between weight gain during the first week and overweight at age 2 among infants with various feeding practices and the relationship between exclusive breastfeeding in early infancy and overweight, we enrolled a prospective cohort of healthy mother-infant dyads and followed them for 2 years. We enrolled 450 mother/infant pairs and obtained information on 306 infants at year 2...
June 21, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28635525/the-role-of-prenatal-obstetric-and-post-partum-factors-in-the-parenting-stress-of-mothers-and-fathers-of-9-month-old-infants
#11
Karen Matvienko-Sikar, Gillian Murphy, Mike Murphy
INTRODUCTION: The aim of this paper was to examine the role of perinatal, obstetric and post partum factors on maternal and paternal stress. It will present the first examination of the role of prenatal, obstetric, post-partum, and demographic variables in parenting stress for mothers and fathers at 9 months. METHODS: Data from 6821 parental dyads of 9-month-old infants were extracted from the Growing Up in Ireland National Longitudinal Study of Children. Participants completed the Parental Stress Scale, the Dyadic Adjustment Scale, the Quality of Attachment Sub-scale from the Maternal and Paternal Postnatal Attachment Scales, and a single item health status question from the Short Form 12 Health Survey...
February 9, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28634850/novel-vitamin-b12-producing-enterococcus-spp-and-preliminary-in-vitro-evaluation-of-probiotic-potentials
#12
Ping Li, Qing Gu, Yuejiao Wang, Yue Yu, Lanlan Yang, Jieyan V Chen
Vitamin B12 is an essential nutrient required for crucial metabolic processes in humans. Vitamin B12-producing lactic acid bacteria (LAB) have been attracting increased attentions currently because of the generally recognized as safe (GRAS) status. Most of recent studies focused on Lactobacillus, and little is known about B12-producing Enterococcus. In the present study, five Enterococcus strains isolated from infant feces were identified as vitamin B12 producers. Among them, Enterococcus faecium LZ86 had the highest B12 production (499...
June 20, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28634626/hepatic-shear-wave-elastography-in-children-under-free-breathing-and-breath-hold-conditions
#13
Caroline Jung, Michael Groth, Kay Uwe Petersen, Anna Hammel, Florian Brinkert, Enke Grabhorn, Sören Alexander Weidemann, Jasmin Busch, Gerhard Adam, Jochen Herrmann
OBJECTIVES: To compare hepatic 2D shear wave elastography (2D SWE) in children between free-breathing and breath-hold conditions, in terms of measurement agreement and time expenditure. METHODS: A cohort of 57 children (12.7±4.3 years) who underwent standardized 2D SWE between May and October 2015 were retrospectively evaluated. Liver elastograms were obtained under free-breathing and breath-hold conditions and time expenditure was measured. Median stiffness, interquartile range (IQR), and IQR/median ratio were calculated based on 12, six, and three elastograms...
June 20, 2017: European Radiology
https://www.readbyqxmd.com/read/28634580/tobacco-use-during-pregnancy-and-its-associated-factors-in-a-mountain-district-of-eastern-nepal-a-cross-sectional-questionnaire-survey
#14
Ramesh Barakoti, Anup Ghimire, Achyut Raj Pandey, Dharani Dhar Baral, Paras K Pokharel
BACKGROUND: Tobacco using among women is more prevalent in Nepal as compared to other South-East Asian countries. The effect of its use is seen not only on the pregnant women, but also health of the growing fetus is compromised. Currently, little is known about the tobacco use among women especially during pregnancy in Nepal. This study explored the tobacco use prevalence and its associated factors during pregnancy. MATERIALS AND METHODS: A cross-sectional study was conducted in Sankhuwasabha, a mountain district of eastern Nepal...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28634574/reducing-viability-bias-in-analysis-of-gut-microbiota-in-preterm-infants-at-risk-of-nec-and-sepsis
#15
Gregory R Young, Darren L Smith, Nicholas D Embleton, Janet E Berrington, Edward C Schwalbe, Stephen P Cummings, Christopher J van der Gast, Clare Lanyon
Necrotising enterocolitis (NEC) and sepsis are serious diseases of preterm infants that can result in feeding intolerance, the need for bowel resection, impaired physiological and neurological development, and high mortality rates. Neonatal healthcare improvements have allowed greater survival rates in preterm infants leading to increased numbers at risk of developing NEC and sepsis. Gut bacteria play a role in protection from or propensity to these conditions and have therefore, been studied extensively using targeted 16S rRNA gene sequencing methods...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28634495/choking-hazards-are-current-product-testing-methods-for-small-parts-adequate
#16
Athena Neofotistos, Nancy Cowles, Ragini Sharma
Choking on small parts remains one of the leading causes of death and injury in infants and toddlers. The current method of testing for small parts, created by the Consumer Product Safety Commission (CPSC), has become outdated and has yet to be changed despite the many deaths and injuries of children. The method uses a device called the small parts test fixture (SPTF) that is supposed to mimic the size of a fully expanded throat of a toddler. If a product does not fit inside the cavity of the SPTF, then it is deemed safe to play with because it "will not fit" in the esophagus of a child...
2017: International Journal of Pediatrics
https://www.readbyqxmd.com/read/28634479/whole-blood-profiling-of-bacillus-calmette-gu%C3%A3-rin-induced-trained-innate-immunity-in-infants-identifies-epidermal-growth-factor-il-6-platelet-derived-growth-factor-ab-bb-and-natural-killer-cell-activation
#17
Steven G Smith, Johanneke Kleinnijenhuis, Mihai G Netea, Hazel M Dockrell
Vaccination of infants with bacillus Calmette-Guérin (BCG) activates both the innate and adaptive arms of the immune response. The antimycobacterial effects of these responses most likely account for the ability of BCG to protect against childhood forms of tuberculosis (TB). There is also evidence for a heterologous protective effect of BCG vaccination against TB-unrelated mortality in low birth weight infants. A possible mechanism of action of this effect, the induction of trained innate immunity, has been demonstrated when cells from BCG-vaccinated adults are restimulated in vitro with non-related microbial stimuli...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28634475/cesarean-or-vaginal-birth-does-not-impact-the-longitudinal-development-of-the-gut-microbiome-in-a-cohort-of-exclusively-preterm-infants
#18
Christopher J Stewart, Nicholas D Embleton, Elizabeth Clements, Pamela N Luna, Daniel P Smith, Tatiana Y Fofanova, Andrew Nelson, Gillian Taylor, Caroline H Orr, Joseph F Petrosino, Janet E Berrington, Stephen P Cummings
The short and long-term impact of birth mode on the developing gut microbiome in neonates has potential implications for the health of infants. In term infants, the microbiome immediately following birth across multiple body sites corresponds to birth mode, with increased Bacteroides in vaginally delivered infants. We aimed to determine the impact of birth mode of the preterm gut microbiome over the first 100 days of life and following neonatal intensive care unit (NICU) discharge. In total, 867 stool samples from 46 preterm infants (21 cesarean and 25 vaginal), median gestational age 27 weeks, were sequenced (V4 region 16S rRNA gene, Illumina MiSeq)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28634380/late-onset-circulatory-collapse-and-continuous-positive-airway-pressure-are-useful-predictors-of-treatment-requiring-retinopathy-of-prematurity-a-9-year-retrospective-analysis
#19
Mitsuru Arima, Shoko Tsukamoto, Kohta Fujiwara, Miwa Murayama, Kanako Fujikawa, Koh-Hei Sonoda
Visual loss caused by retinopathy of prematurity (ROP) will be prevented if treatment-requiring ROP (TR-ROP) can be predicted. In this retrospective study including 418 infants with ≤32 weeks of gestational age (GA) and/or ≤1500 grams of birthweight, we attempted to identify useful predictors. We also examined the efficiency of significant predictors compared with existing predictive models, ROPScore and CHOP model. Multivariable logistic regression analyses supported the following factors were useful for predicting TR-ROP from all infants and infants with any ROP: GA (odds ratio [OR], 0...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634337/evolutionary-and-network-analysis-of-virus-sequences-from-infants-infected-with-an-australian-recombinant-strain-of-human-parechovirus-type-3
#20
Soren Alexandersen, Tiffanie M Nelson, Jason Hodge, Julian Druce
We present the near complete virus genome sequences with phylogenetic and network analyses of potential transmission networks of a total of 18 Australian cases of human parechovirus type 3 (HPeV3) infection in infants in the period from 2012-2015. Overall the results support our previous finding that the Australian outbreak strain/lineage is a result of a major recombination event that took place between March 2012 and November 2013 followed by further virus evolution and possibly recombination. While the nonstructural coding region of unknown provenance appears to evolve significantly both at the nucleotide and amino acid level, the capsid encoding region derived from the Yamagata 2011 lineage of HPeV3 appears to be very stable, particularly at the amino acid level...
June 20, 2017: Scientific Reports
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