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acetylcholinesterase

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https://www.readbyqxmd.com/read/29232097/correction-to-competitive-inhibition-mechanism-of-acetylcholinesterase-without-catalytic-active-site-interaction-study-on-functionalized-c60-nanoparticles-via-in-vitro-and-in-silico-assays
#1
Yanyan Liu, Bing Yan, David A Winkler, Jianjie Fu, Aiqian Zhang
No abstract text is available yet for this article.
December 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29230271/the-role-of-oxidative-stress-in-decreased-acetylcholinesterase-activity-at-the-neuromuscular-junction-of-the-diaphragm-during-sepsis
#2
Hua Liu, Jin Wu, Jun-Yan Yao, Hong Wang, Shi-Tong Li
Our recent study demonstrated that acetylcholinesterase (AChE) activity at the neuromuscular junction (NMJ) of the diaphragm decreased during sepsis. However, the mechanisms were not clearly identified. In this study, we aimed to investigate whether the decreased AChE activity was related to oxidative stress by observing AChE activity in different grades of sepsis induced by caecal ligation and puncture (CLP). At 24 h after surgery, an assay of thiobarbituric acid reactive species (TBARS) and protein carbonyls, as well as the myeloperoxidase (MPO), superoxide dismutase (SOD), and catalase (CAT) activity, was conducted...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29226479/metabolite-profiling-and-isolation-of-biologically-active-compounds-from-scadoxus-puniceus-a-highly-traded-south-african-medicinal-plant
#3
Devashan Naidoo, Lenka Poštová Slavětínská, Adeyemi O Aremu, Jiri Gruz, Ondrej Biba, Karel Doležal, Johannes Van Staden, Jeffrey F Finnie
Scadoxus puniceus (Amaryllidaceae), a medicinal plant of high value in South Africa, is used as a component of a traditional herbal tonic prescribed to treat several ailments. Ultra-high performance liquid chromatography-tandem mass spectrometry quantified the phenolic compounds in different organs of S. puniceus. Gravity column chromatography was used to separate fractions and active compounds. The structure of these compounds was determined using 1D and 2D nuclear magnetic resonance and mass spectroscopic techniques...
December 11, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29224362/structure-determination-and-quantification-of-a-new-flavone-glycoside-with-anti-acetylcholinesterase-activity-from-the-herbs-of-elsholtzia-ciliata
#4
Agung Nugroho, Jong-Hyuk Park, Jae Sue Choi, Kyoung-Sik Park, Joon-Pyo Hong, Hee-Juhn Park
Three acacetin triglycosides (compounds 1, 2 and 3) were isolated from the herbs of Elsholtzia ciliata (Labiatae). The structure were identified as 7-O-β-D-glucopyranosyl-(1 → 2)[α-L-rhamnopyranosyl-(1 → 6)]-β-D-glucopyranoside (compound 1), 7-O-(6-O-acetyl)-β-D-glucopyranosyl-(1 → 2)[α-L-rhamnopyranosyl-(1 → 6)]-β-D-glucopyranoside (compound 2) and 7-O-(6-O-acetyl)-β-D-glucopyranosyl-(1 → 2)[(4-O-acetyl)-α-L-rhamnopyranosyl-(1 → 6)]-β-D-glucopyranoside (compound 3) of acacetin...
December 11, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29212517/is-hematoxylin-eosin-staining-in-rectal-mucosal-and-submucosal-biopsies-still-useful-for-the-diagnosis-of-hirschsprung-disease
#5
Suellen Serafini, Maria Mercês Santos, Ana Cristina Aoun Tannuri, Maria Claudia Nogueira Zerbini, Maria Cecília de Mendonça Coelho, Josiane de Oliveira Gonçalves, Uenis Tannuri
BACKGROUND: Hematoxylin-eosin (HE) staining of a full-thickness rectal wall fragment is classically used for the diagnosis of Hirschsprung disease (HD). However, this technique requires large fragments for a better diagnosis. Additionally, the histochemical and immunohistochemical methods of staining small fragments of rectal mucosal and submucosal biopsies are not available in all centers. Therefore, the possibility of diagnosing HD through HE staining in these biopsies could be a valuable alternative for centers that do not have more specific techniques...
December 6, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/29210299/new-cyclopentaquinoline-hybrids-with-multifunctional-capacities-for-the-treatment-of-alzheimer-s-disease
#6
Kamila Czarnecka, Małgorzata Girek, Karolina Maciejewska, Robert Skibiński, Jakub Jończyk, Marek Bajda, Jacek Kabziński, Przemysław Sołowiej, Ireneusz Majsterek, Paweł Szymański
Alzheimer's disease (AD) is the most common progressive form of brain neurodegeneration and the most prevailing cause of dementia. Unfortunately, the aetiology of AD is not completely studied but different factors are associated with the development of AD such as among others low level of acetylcholine, aggregation of β-amyloid (Aβ), hyperphosphorylated tau protein, oxidative stress, and inflammation. The study encompass organic syntheses of 2,3-dihydro-1H-cyclopenta[b]quinoline with 5,6-dichloronicotinic acid and suitable linkers derivatives as multifunctional agents for AD treatment...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29209218/nootropic-and-neuroprotective-effects-of-dichrocephala-integrifolia-on-scopolamine-mouse-model-of-alzheimer-s-disease
#7
Nadège E Kouémou, Germain S Taiwe, Fleur C O Moto, Simon Pale, Gwladys T Ngoupaye, Jacqueline S K Njapdounke, Gisèle C N Nkantchoua, David B Pahaye, Elisabeth Ngo Bum
Alzheimer's disease the most common form of dementia in the elderly is a neurodegenerative disease that affects 44 millions of people worldwide. The first treatments against Alzheimer's disease are acetylcholinesterase inhibitors; however, these medications are associated with many side effects. Dichrocephala integrifolia is a traditional herb widely used by indigenous population of Cameroon to treat and prevent Alzheimer's disease and for memory improvement. In this study, we evaluated the effect of the decoction prepared from leaves of D...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29207309/polypyridylruthenium-ii-complexes-exert-in-vitro-and-in-vivo-nematocidal-activity-and-show-significant-inhibition-of-parasite-acetylcholinesterases
#8
Madhu Sundaraneedi, Ramon M Eichenberger, Rafid Al-Hallaf, Dai Yang, Javier Sotillo, Siji Rajan, Phurpa Wangchuk, Paul R Giacomin, F Richard Keene, Alex Loukas, J Grant Collins, Mark S Pearson
Over 4.5 billion people are at risk of infection with soil transmitted helminths and there are concerns about the development of resistance to the handful of frontline nematocides in endemic populations. We investigated the anti-nematode efficacy of a series of polypyridylruthenium(II) complexes and showed they were active against L3 and adult stages of Trichuris muris, the rodent homologue of the causative agent of human trichuriasis, T. trichiura. One of the compounds, Rubb12-mono, which was among the most potent in its ability to kill L3 (IC50 = 3...
November 29, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29207043/naringenin-induces-laxative-effects-by-upregulating-the-expression-levels-of-c-kit-and-scf-as-well-as-those-of-aquaporin-3-in-mice-with-loperamide-induced-constipation
#9
Jianqiao Yin, Yichao Liang, Dalu Wang, Zhaopeng Yan, Hongzhuan Yin, Di Wu, Qi Su
Constipation is a common affliction which causes discomfort and affects the quality of life of affected individuals. Naringenin (NAR), a natural flavonoid widely found in citrus fruits and tomatoes, has been reported to exhibit various pharmacological effects, such as anti-inflammatory, anti-atherogenic, anti-mutagenic, hepatoprotective and anticancer effects. Increasing evidence has indicated that NAR has potential for use in the treatment of constipation. Thus, the aim of this study was to evaluate the laxative effects of NAR in mice with loperamide-induced (Lop-induced) constipation...
December 1, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29205106/differential-expression-of-cholinergic-system-components-in-human-induced-pluripotent-stem-cells-bone-marrow-derived-multipotent-stromal-cells-and-induced-pluripotent-stem-cell-derived-multipotent-stromal-cells
#10
Ramona Weist, Thilo Flörkemeier, Yvonne Roger, Annika Franke, Kristin Schwanke, Robert Zweigerdt, Ulrich Martin, Elmar Willbold, Andrea Hoffmann
The components of the cholinergic system are evolutionary very old and conserved molecules that are expressed in typical spatio-temporal patterns. They are involved in signaling in the nervous system whereas their functions in non-neuronal tissues are hardly understood. Stem cells present an attractive cellular system to address functional issues. This study therefore compared human induced pluripotent stem cells (iPSCs; from cord blood endothelial cells), mesenchymal stromal cells derived from induced pluripotent stem cells (iPSC-MSCs) and bone marrow-derived mesenchymal stromal cells (BM-MSCs) from up to 33 different human donors with respect to gene expressions of components of the cholinergic system...
December 5, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/29204935/neuroprotective-potential-of-crocin-against-malathion-induced-motor-deficit-and-neurochemical-alterations-in-rats
#11
Leila Mohammadzadeh, Hossein Hosseinzadeh, Khalil Abnous, Bibi Marjan Razavi
In several epidemiological studies, an association between pesticide exposure and the incidence of Parkinson's disease (PD) has been reported. Increasing evidence showed that oxidative stress plays an important role in the pathogenesis of PD. The present study investigated the preventive effect of crocin, saffron active components, on malathion (an organophosphate pesticide (OP))-induced Parkinson-like behaviors in rat. Rats were divided into eight groups: control (normal saline), malathion (100 mg/kg/day, i...
December 4, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29204442/in-vitro-screening-of-three-indian-medicinal-plants-for-their-phytochemicals-anticholinesterase-antiglucosidase-antioxidant-and-neuroprotective-effects
#12
Mohan Penumala, Raveendra Babu Zinka, Jeelan Basha Shaik, Damu Amooru Gangaiah
Cooccurrence of Diabetes Mellitus and Alzheimer's disease in elder people prompts scientists to develop multitarget agents that combat causes and symptoms of both diseases simultaneously. In line with this modern paradigm and as a follow-up to our previous studies, the present study is designed to investigate the crude methanolic extracts and subsequent CHCl3, n-BuOH, and H2O fractions of Acalypha alnifolia, Pavetta indica, and Ochna obtusata for their inhibitory activities towards specific targets involved in AD and DM, namely, acetylcholinesterase, butyrylcholinesterase, and α-glucosidase (α-Glc)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29202802/histopathology-microbiology-and-the-inflammatory-process-associated-with-sarcoptes-scabiei-infection-in-the-iberian-ibex-capra-pyrenaica
#13
José Espinosa, Arián Ráez-Bravo, Jorge R López-Olvera, Jesús M Pérez, Santiago Lavín, Asta Tvarijonaviciute, Francisco J Cano-Manuel, Paulino Fandos, Ramón C Soriguer, José Enrique Granados, Diego Romero, Roser Velarde
BACKGROUND: Sarcoptic mange has been identified as the most significant infectious disease affecting the Iberian ibex (Capra pyrenaica). Despite several studies on the effects of mange on ibex, the pathological and clinical picture derived from sarcoptic mange infestation is still poorly understood. To further knowledge of sarcoptic mange pathology, samples from ibex were evaluated from histological, microbiological and serological perspectives. METHODS: Samples of skin, non-dermal tissues and blood were collected from 54 ibex (25 experimentally infected, 15 naturally infected and 14 healthy)...
December 4, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29201079/docking-studies-synthesis-and-in-vitro-evaluation-of-novel-oximes-based-on-nitrones-as-reactivators-of-inhibited-acetylcholinesterase
#14
Seyed Ayoub Hosseini, Abolghasem Moghimi, Maryam Iman, Firoz Ebrahimi
Acetylcholinesterase has important role in synaptic cleft. It breaks down the acetylcholineat cholinergic synapsesand terminates the cholinergic effects. Some chemical agents like organophosphorus compounds (OPCs) including nerve agents and pesticides react with acetylcholinesteraseirreversibly. They inhibit normal biological enzyme action and result in accumulation of acetylcholineand show toxic effects andcholinergic symptoms. The process of Acetylcholinesterase (AChE) inhibition can be reversed by a nucleophilic agent to dephosphorylate and reactivate the enzyme...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29201050/the-role-of-ache-in-swimming-behavior-of-daphnia-magna-correlation-analysis-of-both-parameters-affected-by-deltamethrin-and-methomyl-exposure
#15
Qing Ren, Ruibin Zhao, Cheng Wang, Shangge Li, Tingting Zhang, Zongming Ren, Meiyi Yang, Hongwei Pan, Shiguo Xu, Jianping Zhu, Xun Wang
The unpredictable toxicity of insecticides may cause behavior disorder of biological organisms. In order to assess the role of acetylcholinesterase (AChE) in swimming behavior of Daphnia magna, a correlation analysis of both parameters in 24 h exposure of deltamethrin (DM) and methomyl (MT) was investigated. The behavior responses of D. magna in DM (13.36 μg/L and 33.40 μg/L) and MT (19.66 μg/L and 49.15 μg/L) suggested that recovery behavior in the adjustment phase was crucial, and behavior homeostasis provided them with an optimal way to achieve a wider tolerance against environmental stress...
2017: Journal of Toxicology
https://www.readbyqxmd.com/read/29200727/antioxidant-acetylcholinesterase-butyrylcholinesterase-and-%C3%AE-glucosidase-inhibitory-activities-of-corchorus-depressus
#16
Samina Afzal, Bashir Ahmad Chaudhry, Ashfaq Ahmad, Muhammad Uzair, Khurram Afzal
Background: Corchorus depressus (Cd) commonly known as Boa-phalee belonging to the family Tiliaceae having 50 genera and 450 species. Cd is not among the studied medicinal agent despite its potential in ethnopharmacology. Objectives: The present study investigated antioxidant, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α-glucosidase inhibitory activities of Cd. The dichloromethane and methanolic extracts of the Cd were evaluated for biological activities such as antioxidant and enzyme inhibitory activities of AChE, BChE, and α-glucosidase...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29199596/insulin-combined-with-glucose-improves-spatial-learning-and-memory-in-aluminum-chloride-induced-dementia-in-rats
#17
Madhavan Nampoothiri, Grandhi Venkata Ramalingayya, Nampurath Gopalan Kutty, Nandakumar Krishnadas, Chamallamudi Mallikarjuna Rao
Therapeutic intervention using drugs against Alzheimer disease is curative clinically. At present, there are no reports on the curative role of insulin in chronic models of dementia. We evaluated the curative role of insulin and its combination with glucose in dementia. We also investigated the impact of treatments on blood glucose to correlate with cognitive deficit. Further, we analyzed the interaction of treatments with the cholinergic system and oxidative stress in memory centers (i.e., hippocampus and frontal cortex)...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29199432/whey-protein-concentrate-supplementation-protects-rat-brain-against-aging-induced-oxidative-stress-and-neurodegeneration
#18
Geetika Garg, Sandeep Singh, Abhishek Kumar Singh, Syed Ibrahim Rizvi
Whey Protein Concentrate (WPC) is a rich source of sulfur-containing amino acids and is consumed as a functional food, incorporating a wide range of nutritional attributes. The purpose of this study is to evaluate the neuroprotective effect of WPC on rat brain during aging. Young (4 months) and old (24 months) male Wistar rats were supplemented with WPC (300 mg/kg b.w.) for 28 days. Biomarkers of oxidative stress and antioxidant capacity in terms of ferric reducing antioxidant potential (FRAP), lipid hydroperoxide (LHP), total thiol (T-SH), protein carbonyl (PC), reactive oxygen species (ROS), nitric oxide (NO) and acetylcholinesterase activity (AChE) were measured in brain of control and experimental groups...
December 2, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29199383/combined-corticosterone-treatment-and-chronic-restraint-stress-lead-to-depression-associated-with-early-cognitive-deficits-in-mice
#19
Gwladys Temkou Ngoupaye, Francis Bray Yassi, Doriane Amanda Nguepi Bahane, Elisabeth Ngo Bum
Many models, such as chronic mild stress, chronic stress or chronic corticosterone injections are used to induce depression associated with cognitive deficits. However, the induction period in these different models is still long and face constraints when it is short such as in the chronic mild stress done in a minimum period of 21 days. This study aimed to characterize a model of depression with early onset cognitive deficit. 14 days combined chronic injection of corticosterone followed by 2 h restraint stress using a restrainer was used to induce depression with early cognitive deficit onset...
December 3, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29198858/phenolic-components-and-assessment-of-biological-properties-of-tchihatchewia-isatidea-boiss-extracts-docking-and-functional-approaches-for-designing-novel-products
#20
Gokhan Zengin, Hassan H Abdallah, Ahmet Dogan, Adriano Mollica, Zaahira Aumeeruddy-Elalfi, Mohamad Fawzi Mahomoodally
The potentiality of bioactive phenolic compounds may result in plant extracts having multiple biological activities. The aim of this study was to investigate into the biological activities of the methanolic, ethyl acetate, and water extracts of Tchihatchewia isatidea Boiss, an endemic medicinal plant of Turkey. The phenolic compositions of the extracts were confirmed using RP-HPLC. Extracts were screened for their potential antioxidant through a panoply of assays; their anti-diabetic potential, and plausible inhibitory activity against tyrosinase and acetylcholinesterase...
November 30, 2017: Food and Chemical Toxicology
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