Read by QxMD icon Read


Solomon Umukoro, Hassanat Adeola Kalejaye, Benneth Ben-Azu, Abayomi M Ajayi
The effects of naringenin; a dietary flavonoid, with potent anti-oxidant and anti-inflammatory activities on social defeat stress (SDS)-induced neurobehavioral and biochemical changes were evaluated in mice using resident-intruder paradigm. The intruder male mice were distributed into 6 groups (n = 6). Mice in group 1 (control) received vehicle (3% DMSO, i.p), group 2 (SDS-control) were also given vehicle, groups 3-5 received naringenin (10, 25 and 50 mg/kg, i.p.) while group 6 had ginseng (50 mg/kg, i...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Tamires Amabile Valim Brigante, Flavia R Abe, Antônio Waldo Zuardi, Jaime Eduardo Cecílio Hallak, José Alexandre S Crippa, Danielle P de Oliveira
Cannabidiol (CBD) is a non-psychotomimetic compound of the Cannabis sativa that has been used for the treatment of severe epilepsy as well as other diseases of nervous system. However, toxicity studies of CBD have great relevance to guarantee the patients safety. In this context, morphological analyses of zebrafish can contribute to evaluate the teratogenic potential, as well as evaluation of acetylcholinesterase activity and motor activity of zebrafish are valuable tools to verify the neurotoxicity potential...
June 11, 2018: Chemico-biological Interactions
T Zúñiga Santamaría, P Yescas Gómez, I Fricke Galindo, M González González, A Ortega Vázquez, M López López
INTRODUCTION: Alzheimer disease (AD) is the most common cause of dementia and is considered one of the main causes of disability and dependence affecting quality of life in elderly people and their families. Current pharmacological treatment includes acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine) and memantine; however, only one-third of patients respond to treatment. Genetic factors have been shown to play a role in this inter-individual variability in drug response...
June 10, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Chris J Holderman, Daniel R Swale, Jeffery R Bloomquist, Phillip E Kaufman
Horn flies, Haematobia irritans , a major cattle pest in the USA, cause substantial economic losses and current control methods rely heavily on insecticides. Three horn fly populations were evaluated for insecticide susceptibility to permethrin, β-cyfluthrin, and diazinon. Susceptibility was variable by population, with the greatest resistance exhibited by a 66-fold resistance ratio (RR) to permethrin and >14-fold RR to diazinon. Mechanisms of resistance were determined using molecular techniques and enzymatic assays...
June 12, 2018: Insects
Davorka K Hackenberger, Nikolina Stjepanović, Željka Lončarić, Branimir K Hackenberger
Earthworms are exposed to herbicides both through their skin and digestive system. Herbicides can influence earthworms' survival, physiology and reproduction. However, there is a lack of data on herbicide effects on earthworms as they are often regarded as low or non-toxic. The aim of our study was to investigate whether widely used commercial formulations of glyphosate (GLF), tembotrione (TBT) and nicosulfuron (NCS) each applied at three environmentally relevant concentrations have adverse effects on various biomarkers and reproduction in epigeic earthworm Dendrobaena veneta...
June 6, 2018: Chemosphere
Sean X Naughton, Caterina M Hernandez, Wayne D Beck, Indrani Poddar, Nathan Yanasak, Ping-Chang Lin, Alvin V Terry
Organophosphates (OPs) are found in hundreds of valuable agricultural, industrial, and commercial compounds; however, they have also been associated with a variety of harmful effects in humans. The acute toxicity of OPs is attributed to the inhibition of the enzyme acetylcholinesterase (AChE); however, this mechanism may not account for all of the deleterious neurologic effects of OPs, especially at doses that produce no overt signs of acute toxicity. In this study, the effects of two weeks of daily subcutaneous exposure to the OP-nerve agent diisopropylfluorophosphate (DFP) in doses ranging from 0...
June 9, 2018: Toxicology
Nilima A Vyas, Sushma B Singh, Avinash S Kumbhar, Dnyanesh S Ranade, Gulshan R Walke, Prasad P Kulkarni, Vinod Jani, Uddhavesh B Sonavane, Rajendra R Joshi, Srikanth Rapole
Two heteronuclear ruthenium(II)-platinum(II) complexes [Ru(bpy)2 (BPIMBp)PtCl2 ]2+ (3) and [Ru(phen)2 (BPIMBp)PtCl2 ]2+ (4), where bpy = 2,2'-bipyridine, phen = 1,10-phenanthroline, and BPIMBp = 1,4'-bis[(2-pyridin-2-yl)-1H-imidazol-1-ylmethyl]-1,1'-biphenyl, have been designed and synthesized from their mononuclear precursors [Ru(bpy)2 (BPIMBp)]2+ (1) and [Ru(phen)2 (BPIMBp)]2+ (2) as multitarget molecules for Alzheimer's disease (AD). The inclusion of the cis-PtCl2 moiety facilitates the covalent interaction of Ru(II) polypyridyl complexes with amyloid β (Aβ) peptide...
June 12, 2018: Inorganic Chemistry
Hisato Kato, Keiko Komagoe, Tsuyoshi Inoue, Kazufumi Masuda, Takashi Katsu
We analyzed the structure-activity relationship of porphyrins with the photoinactivation of membrane function in bacteria and erythrocytes. The porphyrins tested were protoporphyrin (PP), mesoporphyrin (MP), deuteroporphyrin (DP), hematoporphyrin (HP), coproporphyrin (CP) and uroporphyrin (UP), along with hematoporphyrin derivative (HPD) and photofrin (PF). These porphyrins dissipated membrane potential of Staphylococcus aureus cells depending on the degrees of respiratory inhibition and K+ leakage. The dysfunction of bacterial membrane was caused within minutes and in the order of PP ∼ MP > DP > HPD ≫ HP > PF > CP ∼ UP...
June 12, 2018: Photochemical & Photobiological Sciences
Xu Zhang, K P Rakesh, S N A Bukhari, Moku Balakrishna, H M Manukumar, Hua-Li Qin
The complications of Alzheimer's disease AD were deadly dangerous cause of neurodegenerative disorders connected with the decline of the cognitive functions and loss of memory. The common form of dementia is accounted as the sixth leading cause of the death affecting any stage of people in a lifetime. Synthetic natural chalcone analogs were currently a hot research topic for the treatment of (AD) which has affected millions of peoples throughout the world. The present aim was set to understand the important problems of the AD and its treatment based on natural derivatives of novel chalcones...
June 5, 2018: Bioorganic Chemistry
Xiu-Hua Meng, Hong-Tao Zhu, Hui Yan, Dong Wang, Chong-Ren Yang, Ying-Jun Zhang
Camellia sinensis var. pubilimba is one variety of the genus Camellia sect. Thea (Theaceae) has been used for producing green tea mainly by the local people of its growing areas of Guangxi provinces, China. Forty compounds, including eight C-8 N-ethyl-2-pyrrolidinone substituted flavan-3-ols (1-8) and their substituted unit N-ethyl-5-hydroxy-2-pyrrolidinone (9), four flavan-3-ol monomers (10-13) and one dimer (14), nine flavonoids (15-23), three hydrolysable tannins (24-26), two lignans (27-28), 11 simple phenolics (29-39) and caffeine (40) were firstly isolated and identified from the leaves...
June 11, 2018: Journal of Agricultural and Food Chemistry
Afolabi Clement Akinmoladun, Ibrahim Olabayode Saliu, Boyede Dele Olowookere, Olubukola Benedicta Ojo, Mary Tolulope Olaleye, Ebenezer Olatunde Farombi, Afolabi Akintunde Akindahunsi
Background: Disruption of electrolyte, redox and neurochemical homeostasis alongside cellular energy crisis is a hallmark of cerebral ischaemia and reperfusion injury. Purpose: This study investigated the effect of kolaviron (KV) on cortical and striatal cation imbalance, oxidative stress and neurochemical disturbances as well as neurobehavioural deficits in animals subjected to bilateral common carotid artery occlusion (BCCAO)-induced ischaemia/reperfusion injury...
April 2018: Annals of Neurosciences
Iara da C Souza, Mariana Morozesk, Marina M Bonomo, Vinicius C Azevedo, Marise M Sakuragui, Michael Elliott, Silvia T Matsumoto, Daniel A Wunderlin, María V Baroni, Magdalena V Monferrán, Marisa N Fernandes
Metal/metalloid accumulation in fish organs elicits biochemical responses indicating the overall fish and environmental health status. This study evaluated the bioaccumulation of metals and metalloid in relation to a suite of biochemical biomarkers (superoxide dismutase, catalase, glutathione-S-transferase, Na+/K+-ATPase, H+-ATPase, acetylcholinesterase activities and the levels of glutathione, metallothionein, lipid peroxidation and oxidized protein) in different organs of fish, Centropomus parallelus, in Vitória Bay and Santa Cruz estuaries (State of Espírito Santo, Brazil) with distinct contamination levels...
June 7, 2018: Ecotoxicology and Environmental Safety
P Merino, J A Santos-López, C J Mateos, I Meseguer, A Garcimartín, S Bastida, F J Sánchez-Muniz, J Benedí, M J González-Muñoz
Aluminum consumption has been associated with various neurodegenerative diseases. Previous studies suggest that regular beer intake reverses the pro-oxidant and inflammatory statuses induced by aluminum nitrate intoxication. This paper aims to evaluate the in vitro antioxidant capacity and acetylcholinesterase inhibitory activity of non-alcoholic beer (NABeer), silicon or hops, as well as their effect on animal behavior (e.g. curiosity, immobilization, rearing, grooming, swimming) and brain antioxidant enzyme (activity and gene expression) and anti-inflammatory status in aluminum nitrate intoxicated rats...
June 7, 2018: Food and Chemical Toxicology
Ehsan Ullah Mughal, Asif Javid, Amina Sadiq, Shahzad Murtaza, Muhammad Naveed Zafar, Bilal Ahmad Khan, Sajjad Hussain Sumra, Muhammad Nawaz Tahir, Kanwal, Khalid Mohammed Khan
The prime objective of this research work is to prepare readily soluble synthetic analogues of naturally occurring 3-O-flavonol glycosides and then investigate the influence of various substituents on biological properties of synthetic compounds. In this context, a series of varyingly substituted 3-O-flavonol glycosides have been designed, synthesized and characterized efficiently. The structures of synthetic molecules were unambiguously corroborated by IR, 1 H, 13 C NMR and ESI-MS spectroscopic techniques...
June 1, 2018: Bioorganic & Medicinal Chemistry
Yao-Guo Han, Xiong Qin, Tao Zhang, Ming Lei, Fang-Yuan Sun, Jing-Jing Sun, Wei-Fang Yuan
Oxidative stress and neuroinflammation play an important role in the pathophysiology of lipopolysaccharide (LPS)-induced cognitive impairment. This study aims to observe the effect of electroacupuncture (EA) on the cognitive function in LPS-induced mice, and its regulation on hippocampal α7 nicotinic acetylcholine receptors (α7nAChR), oxidative and proinflammatory factors. Adult male C57BL/6 nice were used to establish animal model of LPS-induced cognitive impairment, and were randomly divided into three groups (n = 16): control group, model group (LPS: 5 mg/kg), and EA group...
June 6, 2018: Neuroscience Letters
Joel A Johnson, Aaron P Montgomery, Eric R Starr, Justin Ludwig, Jennifer Trevitt
The present study examines the effect of three adenosine receptor antagonists on tremulous jaw movements (TJMs), an animal model of tremor. Forty-five rats were pre-treated with one adenosine antagonist: caffeine (0.0, 5.0, or 10.0mg/kg; non-selective adenosine receptor antagonist), 8-cyclopentyltheophylline (CPT; 0.0, 5.0, or 10.0mg/kg; selective adenosine A1 receptor antagonist), or SCH 58261 (0.0 or 8.0mg/kg; selective adenosine A2A receptor antagonist) followed by TJM induction with tacrine (0.0, 0.75, or 2...
June 5, 2018: European Journal of Pharmacology
Yongfeng Zhang, Jiaqi Wang, Chunyue Wang, Zhiping Li, Xin Liu, Jun Zhang, Jiahui Lu, Di Wang
Evodiamine (Evo), a major alkaloid compound isolated from the dry unripened fruit of Evodia fructus, has a wide range of pharmacological activities. The present study sought to explore the neuroprotective effects of Evo in l-glutamate (l-Glu)-induced apoptosis of HT22 cells, and in a d-galactose and aluminum trichloride-developed Alzheimer’s disease (AD) mouse model. Evo significantly enhanced cell viability, inhibited the accumulation of reactive oxygen species, ameliorated mitochondrial function, increased the B-cell lymphoma-2 protein content, and inhibited the high expression levels of Bax, Bad, and cleaved-caspase-3 and -8 in l-Glu-induced HT22 cells...
May 21, 2018: International Journal of Molecular Sciences
Kerem Teralı, Ozlem Dalmizrak, Qendresa Hoti, Nazmi Ozer
Abamectin, a blend of the natural avermectins B1a and B1b , is a widely-used insecticide/miticide with relatively low toxicity to mammals. Exposure to high doses of it, however, leads to cholinergic-like neurotoxic effects. Butyrylcholinesterase, which is best known for its abundant presence in plasma, is a serine hydrolase loosely coupled with the cholinergic system. It protects and supports the neurotransmitter function of its sister enzyme acetylcholinesterase. Here, using experimental and computational studies, we provide evidence demonstrating that abamectin is a potent (IC50 = 10...
June 8, 2018: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
Huaqiang Li, Weiguang Sun, Mengyi Deng, Changxing Qi, Chunmei Chen, Hucheng Zhu, Zengwei Luo, Jianping Wang, Yongbo Xue, Yonghui Zhang
Asperversins A ( 1 ) and B ( 2 ), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues ( 3 ⁻ 7 ) and a known compound asperdemin ( 8 ), were obtained from the marine-derived fungus Aspergillus versicolor . Their structures and absolute configurations were confirmed by extensive spectroscopic analyses, single-crystal X-ray diffraction studies, and electronic circular dichroism (ECD) calculation. All new compounds were tested for their acetylcholinesterase enzyme (AChE) inhibitory activities and cytotoxic activities, of which compound 7 displayed moderate inhibitory activity against the AChE with an IC50 value of 13...
May 23, 2018: Marine Drugs
Pathise Souto Oliveira, Vitor Clasen Chaves, Mayara Sandrielly Pereira Soares, Natália Pontes Bona, Lorenço Torres Mendonça, Fabiano Barbosa Carvalho, Jessié Martins Gutierres, Flávia Aleixo Vasconcellos, Marcia Vizzotto, Andriele Vieira, Roselia Maria Spanevello, Flávio Henrique Reginatto, Claiton Leoneti Lencina, Francieli Moro Stefanello
In this work, we evaluated the effects of Psidium cattleianum (Red Type) (PcRT) fruit extract on metabolic, behavioral, and neurochemical parameters in rats fed with a highly palatable diet (HPD) consisted of sucrose (65% carbohydrates being 34% from condensed milk, 8% from sucrose and 23% from starch, 25% protein and 10% fat). Animals were divided into 4 groups: standard chow, standard chow + PcRT extract (200 mg/Kg/day by gavage), HPD, HPD + extract. The animals were treated for 150 days. Concerning chemical profiling, LC/PDA/MS/MS analysis revealed cyanidin-3-O-glucoside as the only anthocyanin in the PcRT extract...
June 7, 2018: Metabolic Brain Disease
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"