keyword
https://read.qxmd.com/read/38482252/an-unexpected-case-of-large-cell-neuroendocrine-carcinoma-of-the-colon-a-case-report
#21
Kingsley Nnawuba, Dylan Travis, Hanna Jensen, Blake Lockwood
BACKGROUND: Patients presenting with large cell neuroendocrine carcinomas (LCNECs) comprise a small minority of total colon and rectal cancers (1-2%) with poor prognostic outcomes in lieu of late diagnosis and metastasis at the point of diagnosis. CASE DESCRIPTION: We report a case presentation of a 69-year-old male presenting with diffuse, non-severe upper abdominal pain and a positive at-home colon cancer screening test. At the time of presentation, the patient was negative for constipation or blood in stool...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38476924/erratum-corrigendum-pien-tze-huang-inhibits-hypoxia%C3%A2-induced-epithelial%C3%A2-mesenchymal-transition-in-human-colon-carcinoma-cells-through-suppression-of-the-hif%C3%A2-1-pathway
#22
Hongwei Chen, Aling Shen, Yuchen Zhang, Youqin Chen, Jiumao Lin, Wei Lin, Thomas Sferra, Jun Peng
[This corrects the article DOI: 10.3892/etm.2014.1549.].
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38476281/dual-stimuli-responsive-gut-microbiota-targeting-nitidine-chloride-cs-pt-nps-improved-metabolic-status-in-nafld
#23
JOURNAL ARTICLE
Jianmei Lu, Yongzhu Zeng, Huashuai Zhong, Wei Guo, Yuyan Zhang, Wanting Mai, Yucui Qin, Xiaodan Su, Bo Zhang, Weisen Wu, Yu Zhu, Qiujie Huang, Yong Ye
BACKGROUND AND PURPOSE: Nitidine chloride (NC) is a botanical drug renowned for its potent anti-inflammatory, antimalarial, and hepatocellular carcinoma-inhibiting properties; however, its limited solubility poses challenges to its development and application. To address this issue, we have devised a colon-targeted delivery system (NC-CS/PT-NPs) aimed at modulating the dysbiosis of the gut microbiota by augmenting the interaction between NC and the intestinal microbiota, thereby exerting an effect against nonalcoholic fatty liver disease...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38474727/in-vitro-lactic-acid-bacteria-anti-hepatitis-b-virus-hbv-effect-and-modulation-of-the-intestinal-microbiota-in-fecal-cultures-from-hbv-associated-hepatocellular-carcinoma-patients
#24
JOURNAL ARTICLE
Juan Yang, He Gao, Tiantian Zhang, Yong Fan, Yuwei Wu, Xinyu Zhao, Ying Li, Lei Wu, Hui Zhao, Lingshuang Yang, Haojie Zhong, Longyan Li, Xinqiang Xie, Qingping Wu
Hepatocellular carcinoma (HCC), being ranked as the top fifth most prevalent cancer globally, poses a significant health challenge, with a considerable mortality rate. Hepatitis B virus (HBV) infection stands as the primary factor contributing to HCC, presenting substantial challenges in its treatment. This study aimed to identify lactic acid bacteria (LAB) with anti-HBV properties and evaluate their impact on the intestinal flora in HBV-associated HCC. Initially, two LAB strains, Levilactobacillus brevis SR52-2 ( L...
February 22, 2024: Nutrients
https://read.qxmd.com/read/38473913/hemochromatosis-ferroptosis-ros-gut-microbiome-and-clinical-challenges-with-alcohol-as-confounding-variable
#25
REVIEW
Rolf Teschke
Hemochromatosis represents clinically one of the most important genetic storage diseases of the liver caused by iron overload, which is to be differentiated from hepatic iron overload due to excessive iron release from erythrocytes in patients with genetic hemolytic disorders. This disorder is under recent mechanistic discussion regarding ferroptosis, reactive oxygen species (ROS), the gut microbiome, and alcohol abuse as a risk factor, which are all topics of this review article. Triggered by released intracellular free iron from ferritin via the autophagic process of ferritinophagy, ferroptosis is involved in hemochromatosis as a specific form of iron-dependent regulated cell death...
February 25, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38469604/the-prognostic-importance-of-cancer-stem-cells-in-colorectal-polyps
#26
JOURNAL ARTICLE
Aynur Safiyeva, Nuru Bayramov, Mustafa Cihat Avunduk
BACKGROUND: This purpose aims to investigate the usefulness of CD133, a stem cell marker, for the prognosis of colon polyps. This study aimed to assess the adenomatous polyps that have an essential role in the development of colorectal cancer. The risk of colorectal carcinogenesis can be reduced by polypectomy and close medical supervision of the patients with adenomatous polyps. The prominence of stem cells in carcinoma development is also a recognized verdict. It must be noted that stem cell evaluation in adenomatous polyps may provide information about carcinoma development...
2024: Annali Italiani di Chirurgia
https://read.qxmd.com/read/38469575/distal-fibular-metastasis-of-colorectal-carcinoma-a-case-report
#27
JOURNAL ARTICLE
Lauren Luther, Patrick J McGlone, Kyle D Hardacker, Daniel Alsoof, Roman A Hayda, Richard M Terek
CASE: A 62-year-old woman presenting with ankle pain was initially treated for a non-displaced fracture. Persistent pain despite months of conservative management for her presumed injury prompted repeat radiographs which demonstrated the progression of a lytic lesion and led to an orthopedic oncology referral. Following a complete work-up, including biopsy and staging, she was diagnosed with colorectal carcinoma metastatic to the distal fibula. CONCLUSION: Secondary tumors of the fibula are uncommon but an important diagnosis to consider for intractable lower extremity pain especially in patients with history of malignancy or lack of age-appropriate cancer screening...
2024: Orthopedic Reviews
https://read.qxmd.com/read/38467302/mathematical-modeling-of-combined-therapies-for-treating-tumor-drug-resistance
#28
JOURNAL ARTICLE
Kangbo Bao, Guizhen Liang, Tianhai Tian, Xinan Zhang
Drug resistance is one of the most intractable issues to the targeted therapy for cancer diseases. To explore effective combination therapy schemes, we propose a mathematical model to study the effects of different treatment schemes on the dynamics of cancer cells. Then we characterize the dynamical behavior of the model by finding the equilibrium points and exploring their local stability. Lyapunov functions are constructed to investigate the global asymptotic stability of the model equilibria. Numerical simulations are carried out to verify the stability of equilibria and treatment outcomes using a set of collected model parameters and experimental data on murine colon carcinoma...
March 9, 2024: Mathematical Biosciences
https://read.qxmd.com/read/38465160/the-clinicopathological-correlation-of-kras-mutation-and-pten-expression-status-in-primary-and-metastatic-colorectal-carcinoma
#29
JOURNAL ARTICLE
Redir T Hassan, Bashar Al Hassawi, Maysoon Alkazzaz
BACKGROUND: Colorectal cancer (CRC) research has identified a consistent loss of PTEN expression in both primary tumors and metastasis, highlighting its potential role in this disease. However, the impact of PTEN on downstream proteins of KRAS mutation, namely p-AKT, p-ERK, and p65 (NFkB), remains unknown. This study aims to explore the inhibitory effect of PTEN on KRAS downstream proteins and its correlation with pathological features in CRC patients. METHODS: From January 1, 2015, to December 31, 2021, 86 CRC cases were collected from governmental and private laboratories in the Duhok province...
February 2024: Curēus
https://read.qxmd.com/read/38463578/cdca8-a-mitosis-related-gene-as-a-prospective-pan-cancer-biomarker-implications-for-survival-prognosis-and-oncogenic-immunology
#30
JOURNAL ARTICLE
Hanjie Hu, Muhammad Umair, Sikandar Ali Khan, Aliya Irshad Sani, Sahar Iqbal, Fatima Khalid, Rizwana Sultan, Mostafa A Abdel-Maksoud, Ayman Mubarak, Turki M Dawoud, Abdul Malik, Ibrahim A Saleh, Abdul Aziz Al Amri, Norah Khaled Algarzae, Ahmad S Kodous, Yasir Hameed
BACKGROUND: Human cell division cycle-associated protein 8 (CDCA8), a critical regulator of mitosis, has been identified as a prospective prognostic biomarker in several cancer types, including breast, colon, and lung cancers. This study analyzed the diagnostic/prognostic potential and clinical implications of CDCA8 across diverse cancers. METHODS: Bioinformatics and molecular experiments. RESULTS: Analyzing TCGA data via TIMER2 and GEPIA2 databases revealed significant up-regulation of CDCA8 in 23 cancer types compared to normal tissues...
2024: American Journal of Translational Research
https://read.qxmd.com/read/38452580/cadherin-17-cdh17-expression-in-human-cancer-a-tissue-microarray-study-on-18-131-tumors
#31
JOURNAL ARTICLE
Frank Jacobsen, Ramesh Pushpadevan, Florian Viehweger, Morton Freytag, Ria Schlichter, Natalia Gorbokon, Franziska Büscheck, Andreas M Luebke, Devita Putri, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Doris Höflmayer, Christoph Fraune, Christian Bernreuther, Patrick Lebok, Guido Sauter, Sarah Minner, Stefan Steurer, Ronald Simon, Eike Burandt, David Dum, Florian Lutz, Andreas H Marx, Till Krech, Till S Clauditz
Cadherin-17 (CDH17) is a membranous cell adhesion protein predominantly expressed in intestinal epithelial cells. CDH17 is therefore considered a possible diagnostic and therapeutic target. This study was to comprehensively determine the expression of CDH17 in cancer and to further assess the diagnostic utility of CDH17 immunohistochemistry (IHC). A tissue microarray containing 14,948 interpretable samples from 150 different tumor types and subtypes as well as 76 different normal tissue types was analyzed by IHC...
January 28, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38450071/case-report-resolution-of-guillain-barr%C3%A3-syndrome-in-a-patient-with-dual-primary-tumors-after-treatment-with-rituximab
#32
Desheng Zhang, You Wang, Fuxiang Zhou
Guillain-Barré syndrome (GBS) is a rare immune-related adverse event (irAE) that can occur in solid tumors such as hepatocellular carcinoma, gastric cancer, breast cancer, and colorectal cancer. It is characterized by progressive myasthenia and mild sensory abnormalities. The emergence of immune checkpoint inhibitors (ICIs) has significantly improved cancer patients' life expectancy but can also trigger various irAEs, including GBS. We report a rare case of GBS in a 64-year-old male patient with dual primary tumors of the colon and stomach who received toripalimab and chemotherapy for liver metastases...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38449931/a-case-report-on-alpha-fetoprotein-positive-colorectal-cancer
#33
Wendy Hui Li Yap, Hajah Maisarah Haji Awang Sharif, Amy Thien
Alpha-fetoprotein (AFP) is commonly produced by hepatocellular carcinoma and yolk sac tumors, while AFP in colorectal cancer (CRC) is a rare association. We report a case of a patient with primary AFP-producing CRC, which was successfully treated with surgery and adjuvant chemotherapy. This case highlighted the importance of recognizing a case of AFP-producing CRC.  This case report discussed a 59-year-old male who had a history of hepatitis B infection, with two months of intermittent fresh per rectal bleeding...
February 2024: Curēus
https://read.qxmd.com/read/38449797/hepatocellular-carcinoma-in-a-transplanted-donor-liver-and-colon-cancer-developing-in-a-patient-with-a-complex-background-a-case-report
#34
Sayoko Sumiyoshi, Terumi Takahara, Kazuto Shibuya, Johji Imura, Akira Noguchi, Kazuto Tajiri, Masami Minemura, Tsutomu Fujii, Kenichi Hirabayashi
The development of tumors in livers transplanted from hepatitis B virus (HBV)-negative donors to patients with hepatitis B and cirrhosis is rare. The present study describes the case of a woman in her 60s who developed hepatocellular carcinoma (HCC) in her grafted liver, 19 years after transplantation, as well as a metachronous colorectal tumor. The pathological findings, including clinical, immunohistochemical and molecular results, are described in the present case report. The liver tumor was a conventional HCC and the colorectal tumor comprised a tubular adenocarcinoma...
April 2024: Oncology Letters
https://read.qxmd.com/read/38446215/an-insight-into-thymidylate-synthase-inhibitor-as-anticancer-agents-an-explicative-review
#35
REVIEW
Aratrika Sen, Dipanjan Karati
Cancer, a widespread challenge to global health, remains a puzzle of intricate molecular dynamics. This review article delves into the mystery of cancer, with a keen focus on understanding the contributory role of thymidylate synthase (TS) in cancer. TS, a vital enzyme in DNA synthesis and repair, emerges as a significant player in the narrative of cancer development. The conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) is a major step in producing DNA. Numerous malignancies, including those of the breast, colon, lung, and ovary, have been linked to dysregulation of TS activity...
March 6, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38445916/improved-survival-of-patients-receiving-immunotherapy-and-chemotherapy-following-curative-intent-resection-of-colorectal-liver-metastases
#36
JOURNAL ARTICLE
Tommaso Pollini, Thuy Tran, Paul Wong, Mohamed A Adam, Adnan Alseidi, Carlos Corvera, Kenzo Hirose, Eric Nakakura, Robert Warren, Vijay K Maker, Ajay V Maker
BACKGROUND: Despite significant advancements in the treatment of patients with colorectal liver metastases (CRLMs), only a minority will experience long-term survival. This study aimed to determine the effect of chemotherapy (CT) and immunotherapy (IT) compared with that of CT alone on patient survival after surgical resection. METHODS: Patients undergoing curative-intent liver resection followed by adjuvant systemic therapy for stage IV colon cancer were identified using the National Cancer Database...
March 2024: Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38444942/the-anticancer-activity-of-bile-acids-in-drug-discovery-and-development
#37
REVIEW
Weijian Li, Lu Zou, Shuai Huang, Huijie Miao, Ke Liu, Yajun Geng, Yingbin Liu, Wenguang Wu
Bile acids (BAs) constitute essential components of cholesterol metabolites that are synthesized in the liver, stored in the gallbladder, and excreted into the intestine through the biliary system. They play a crucial role in nutrient absorption, lipid and glucose regulation, and the maintenance of metabolic homeostasis. In additional, BAs have demonstrated the ability to attenuate disease progression such as diabetes, metabolic disorders, heart disease, and respiratory ailments. Intriguingly, recent research has offered exciting evidence to unveil their potential antitumor properties against various cancer cell types including tamoxifen-resistant breast cancer, oral squamous cell carcinoma, cholangiocarcinoma, gastric cancer, colon cancer, hepatocellular carcinoma, prostate cancer, gallbladder cancer, neuroblastoma, and others...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38444383/pleomorphic-carcinoma-of-the-lung-revealed-by-uncommon-colonic-metastasis-an-exceptional-case-report-with-literature-review
#38
JOURNAL ARTICLE
Mouna Zghal, Saadia Makni, Marwa Bouhamed, Nermine Ellouze, Rim Kallel, Naourez Gouiaa, Tahya Boudawara, Ons Boudawara
Lung pleomorphic carcinoma is a rare and aggressive cancer that uncommonly metastasizes to the colon and only a few case reports have been published thus far. We present an exceptional case of colon metastasis from lung pleomorphic carcinoma in a 68-year-old man which was revealed by large bowel perforation, and we review the previous three published cases. Metastasis to the bowel from primary lung malignancy often lacks specific symptoms which result in delayed diagnosis. Bowel metastasis is a poor prognostic factor in patients with lung pleomorphic carcinoma, regardless of management strategy...
March 6, 2024: Asian Cardiovascular & Thoracic Annals
https://read.qxmd.com/read/38440227/case-report-an-unusual-presentation-of-intra-abdominal-desmoplastic-small-round-cell-tumor
#39
Akshay Nilesh Desai, Christine Jane Kurian, William Rafferty, Danielle Lajoie Behrens, Polina Khrizman
BACKGROUND: Intra-abdominal desmoplastic small round cell tumor (IDSRCT) is a rare entity (0.2-0.74 cases per million people per year), which predominantly occurs in young men. It may present as an abdominal mass with pain, distention, and constipation. IDSRCT has a very poor prognosis, with 5-year overall survival estimated at 15%-30%. Diagnosis is made with tissue biopsy. CASE DESCRIPTION: We present a case of a 28-year-old man with a history of schizophrenia and depression who presented to an emergency room (ER) in November 2022 with constipation and pelvic pain...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38439989/a-dataset-of-microstructure-features-of-electro-hydrodynamic-assisted-5-fluorouracil-grafted-alginate-microbeads-and-physicochemical-properties-for-effective-colon-targeted-carriers-drug-delivery
#40
JOURNAL ARTICLE
Abul Kalam Azad, Wan Mohd Azizi Wan Sulaiman, Hassan Almoustafa, Mohamad Dayoob, Vinoth Kumarasamy, Vetriselvan Subramaniyan, Jamilah M Alshehri, Azmat Ali Khan
5-Fluorouracil (5-FU) has been the primary drug used in chemotherapy for colorectal carcinoma, and localizing the drug would be effective in avoiding its side effects and improving therapeutic outcomes. One approach to achieve this is by encapsulating the drug in microbeads. Alginate microbeads, in particular, exhibit promising pH-sensitive properties, making them an attractive option for colon targeting. Thus, the main aim of this study is to formulate and characterize 5-FU-encapsulated alginate microbeads as a pH-sensitive drug delivery system for controlled release in the gastrointestinal tract...
April 2024: Data in Brief
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