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Vagal nerve

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https://www.readbyqxmd.com/read/28806271/luminal-chemosensing-in-the-gastroduodenal-mucosa
#1
Izumi Kaji, Jonathan D Kaunitz
PURPOSE OF REVIEW: We report recently published knowledge regarding gut chemosensory mechanisms focusing on nutrient-sensing G protein-coupled receptors (GPCRs) expressed on gut enteroendocrine cells (EECs), tuft cells, and in afferent nerves in the gastroduodenal mucosa and submucosa. RECENT FINDINGS: Gene profiling of EECs and tuft cells have revealed expression of a variety of nutrient-sensing GPCRs. The density of EEC and tuft cells is altered by luminal environmental changes that may occur following bypass surgery or in the presence of mucosal inflammation...
August 12, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28803834/transcutaneous-auricular-vagal-nerve-stimulation-tavns-might-be-a-mechanism-behind-the-analgesic-effects-of-auricular-acupuncture
#2
Taras Usichenko, Henriette Hacker, Martin Lotze
BACKGROUND: Randomized clinical trials (RCT) demonstrated that auricular acupuncture (AA) is effective in treatment of acute and chronic pain, although the mechanisms behind AA are not elucidated. METHODS: The data concerning the localization of AA points, which are commonly used to treat pain, were extracted from the meta-analysis of 17 RCTs and evaluated using the anatomical map of auricular afferent nerve supply. RESULTS: Fifteen out of 20 specific AA points, used in the treatment of pain, are situated in areas innervated mostly by the auricular branch of the vagal nerve (ABVN), whereas sham stimulation was applied at the helix of the auricle, innervated by cervical nerves...
August 2, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28797983/rationalisation-of-the-irrational-neuropathological-basis-of-hypothyroidism-olfaction-disorders-paradox-experimental-study
#3
Nazan Aydin, Leyla Ramazanoglu, Mehmet Resid Onen, Ilhan Yilmaz, Mehmet Dumlu Aydin, Konca Altinkaynak, Muhammet Calik
OBJECTIVE: Hypothyroidism is defined as an underactive thyroid gland and one of the reasons for inadequate stimulation of thyroid is dysfunction of the hormone regulating brain centers. Olfaction disorders have been considered as a problem in hypothyroidism. It has been hypothesised that olfaction disorders reduce olfactory stimulation and diminished olfactory stimulus may trigger hypothyroidism. In this study an examination was made of the thyroid hormone levels, histological features of thyroid glands and vagal nerve network degradation in an experimental animal model of olfactory bulbectomy (OBX)...
August 7, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28766392/vagal-influences-in-rheumatoid-arthritis
#4
S E Rasmussen, M Pfeiffer-Jensen, A M Drewes, A D Farmer, B W Deleuran, K Stengaard-Pedersen, B Brock, C Brock
Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease with a prevalence of 0.5-1% in Western populations. Conventionally, it is treated with therapeutic interventions that include corticosteroids, disease-modifying anti-rheumatic drugs, and biological agents. RA exerts a significant socio-economic burden and despite the use of existing treatments some patients end up with disabling symptoms. The autonomic nervous system (ANS) is a brain-body interface that serves to regulate homeostasis by integrating the external environment with the internal milieu...
August 2, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28758244/lung-transplantation-delays-gastric-motility-in-patients-without-prior-gastro-intestinal-surgery-a-single-center-experience-of-412-consecutive-patients
#5
Sameer A Hirji, Brian C Gulack, Brian R Englum, Paul J Speicher, Asvin M Ganapathi, Asishana A Osho, Rahul A Shimpi, Alexander Perez, Matthew G Hartwig
PURPOSE: To examine the impact of lung transplantation on gastric motility. METHODS: Adult recipients at a large, single center, who were retrospectively evaluated with solid gastric emptying (SGE) study post lung transplantation, but had no history of gastrointestinal intervention (i.e. pyloroplasty or fundoplication), were selected between June 2005 and August 2013. Multivariable logistic regression was performed to determine risk factors associated with delayed gastric emptying (DGE) after transplantation...
July 31, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28745812/neuronal-control-of-experimental-colitis-occurs-via-sympathetic-intestinal-innervation
#6
R A Willemze, O Welting, H P van Hamersveld, S L Meijer, J H A Folgering, H Darwinkel, J Witherington, A Sridhar, M J Vervoordeldonk, J Seppen, W J de Jonge
BACKGROUND: Vagus nerve stimulation is currently clinically evaluated as a treatment for inflammatory bowel disease. However, the mechanism by which this therapeutic intervention can have an immune-regulatory effect in colitis remains unclear. We determined the effect of intestine-specific vagotomy or intestine-specific sympathectomy of the superior mesenteric nerve (SMN) on dextran sodium sulfate (DSS)-induced colitis in mice. Furthermore, we tested the efficacy of therapeutic SMN stimulation to treat DSS-induced colitis in rats...
July 26, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28745303/extracellular-ph-monitoring-for-use-in-closed-loop-vagus-nerve-stimulation
#7
Simon C Cork, Amir Eftekhar, Khalid B Mirza, James V Gardiner, Stephen R Bloom, Christofer Toumazou
OBJECTIVE: Vagal nerve stimulation (VNS) has shown potential benefits for obesity treatment; however current devices lack physiological feedback, which limit their efficacy. Changes in extracellular pH (pH<sub>e</sub>) have shown to be correlated with neural activity, but have traditionally been measured with glass microelectrodes, which limit their in vivo applicability. APPROACH: Iridium oxide has previously been shown to be sensitive to fluctuations in pH and is biocompatible...
July 26, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28737621/baroreflex-activation-therapy-a-new-approach-to-the-management-of-advanced-heart-failure-with-reduced-ejection-fraction
#8
Edoardo Gronda, Darrel Francis, Faiez Zannad, Christian Hamm, Josep Brugada, Emilio Vanoli
: Chronic heart failure is a common clinical condition characterized by persistent excessive sympathetic nervous system activation. The derangement of the sympathetic activity has relevant implications for disease progression and patient survival. Aiming to positively impact patient outcome, autonomic nervous system modulatory therapies have been developed and tested in animal and clinical studies. As a general gross assumption, direct vagal stimulation and baroreflex activation are considered equivalent. This assumption does not take into account the fact that direct cervical vagal nerve stimulation involves activation of both afferent and efferent fibers innervating not only the heart, but the entire visceral system, leading to undesired responses to and from this compartment...
September 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28730326/infectious-diseases-causing-autonomic-dysfunction
#9
REVIEW
Francisco Javier Carod Artal
OBJECTIVES: To review infectious diseases that may cause autonomic dysfunction. METHODS: Review of published papers indexed in medline/embase. RESULTS: Autonomic dysfunction has been reported in retrovirus (human immunodeficiency virus (HIV), human T-lymphotropic virus), herpes viruses, flavivirus, enterovirus 71 and lyssavirus infections. Autonomic dysfunction is relatively common in HIV-infected patients and heart rate variability is reduced even in early stages of infection...
July 20, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28719827/mixed-evidence-for-the-potential-of-non-invasive-transcutaneous-vagal-nerve-stimulation-to-improve-the-extinction-and-retention-of-fear
#10
A M Burger, B Verkuil, H Fenlon, L Thijs, L Cools, H C Miller, B Vervliet, I Van Diest
Extinction memories are fragile and their formation has been proposed to partially rely on vagus nerve activity. We tested whether stimulating the auricular branch of the vagus (transcutaneous VNS; tVNS) accelerates extinction and reduces spontaneous recovery of fear. Forty-two healthy students participated in a 3-day fear conditioning study, where we tested fear acquisition (day 1), fear extinction (day 2) and the retention of the extinction memory (day 3). During extinction, participants were randomly allocated to receive tVNS or sham stimulation concurrently with each CS presentation...
July 8, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28717527/vagal-paraganglioma-presenting-as-a-neck-mass-associated-with-cough-on-palpation
#11
Richard Heyes, Nizar Taki, Miriam A O'Leary
A 70-year-old female presented with a neck mass and sporadic dry cough, often leading to fits of coughing severe enough to cause vomiting. The patient reported that touching the mass triggered the cough. On examination, a 2.5 cm right-sided level two neck mass deep to the sternocleidomastoid was present. Palpation of the mass immediately triggered coughing. Cross-sectional imaging proposed vagal paraganglioma as the chief differential, which was confirmed following surgical excision. The patient reported complete resolution of her severe dry cough after surgery...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28705925/management-of-hiccups-in-palliative-care-patients
#12
REVIEW
Yong Suk Jeon, Alison Mary Kearney, Peter Graham Baker
Persistent hiccups are a frustrating experience for palliative care patients, and can have a profound impact on their quality of life. This article provides an evidence-based approach overview of the causes and treatment of this not infrequently debilitating condition for such patients, with a management algorithm. In situations where no readily reversible cause is identified, or where simple physical manoeuvres, such as breath holding have failed, a systematic approach is required. Hiccups can be broadly divided into central and peripheral types...
July 13, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28705842/facial-palsy-and-atrial-fibrillation-a-special-case-of-ramsay-hunt-syndrome
#13
Fares Ayoub, Dhruv Mahtta, Roland-Austin Federico, Michael Kaufmann
Ramsay Hunt syndrome (herpes zoster oticus) is a rare complication of latent Varicella Zoster virus infection. It can be complicated by permanent hearing loss, loss of taste and postherpetic neuralgia. Although Ramsay Hunt syndrome most prominently involves the facial nerve, a number of other cranial nerves can be involved such as the vestibulocochlear, glossopharyngeal and the vagus nerve. We report on a case of Ramsay Hunt syndrome with cranial polyneuritis complicated by atrial fibrillation. Vagal involvement as evidenced by physical examination and MRI findings was present in our patient...
July 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28703308/odors-generated-from-the-maillard-reaction-affect-autonomic-nervous-activity-and-decrease-blood-pressure-through-the-olfactory-system
#14
Lanxi Zhou, Motoko Ohata, Chisato Owashi, Katsuya Nagai, Issei Yokoyama, Keizo Arihara
BACKGROUND: Systolic blood pressure of rats decreases significantly following exposure to the odor generated from the Maillard reaction of protein digests with xylose. In the current study, we identified active odorants that affect blood pressure and demonstrated the mechanism of action. RESULTS: Among the four potent odorants that contribute most to the odor of the Maillard reaction sample, 2,5-dimethyl-4-hydroxy-3(2H)-furanone and 5-methylpyrazine-2-methanol decreased systolic blood pressure significantly...
July 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28701913/common-hepatic-branch-of-vagus-nerve-dependent-expression-of-immediate-early-genes-in-the-mouse-brain-by-intraportal-l-arginine-comparison-with-cholecystokinin-8
#15
Daisuke Yamada, Peter Koppensteiner, Saori Odagiri, Megumi Eguchi, Shun Yamaguchi, Tetsuya Yamada, Hideki Katagiri, Keiji Wada, Masayuki Sekiguchi
Information from the peripheral organs is thought to be transmitted to the brain by humoral factors and neurons such as afferent vagal or spinal nerves. The common hepatic branch of the vagus (CHBV) is one of the main vagus nerve branches, and consists of heterogeneous neuronal fibers that innervate multiple peripheral organs such as the bile duct, portal vein, paraganglia, and gastroduodenal tract. Although, previous studies suggested that the CHBV has a pivotal role in transmitting information on the status of the liver to the brain, the details of its central projections remain unknown...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28694158/implication-of-the-vagus-nerve-in-breathing-pattern-during-sequential-swallowing-in-rats
#16
Yacine Ouahchi, Celia Duclos, Jean Paul Marie, Eric Verin
The ventilatory pattern during sequential swallowing is influenced by the vagal activity. As the vagus nerve is paired and mixed, we aimed (1) to determine if vagal implication in swallowing and breathing coordination is symmetric. (2) to study the importance of vagal afferences in swallowing and breathing coordination. Sixty two Wistar rats (7-11weeks, 260-400g) were studied by barometric plethysmography. In the first part of the study, we determined the effects of a right cervical vagotomy and the effects of a left cervical vagotomy on ventilatory pattern at rest and during sequential swallowing (14 rats with right vagotomy, 14 rats with left vagotomy and 14 rats with sham surgery)...
July 8, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28693820/central-glucagon-like-peptide-1-inhibits-reflex-swallowing-elicited-by-the-superior-laryngeal-nerve-via-caudal-brainstem-in-the-rat
#17
Motoi Kobashi, Satoshi Mizutani, Masako Fujita, Yoshihiro Mitoh, Yuichi Shimatani, Ryuji Matsuo
The effects of glucagon like peptide-1 (GLP-1) on reflex swallowing were examined using anaesthetized rats. GLP-1 was injected into the dorsal vagal complex (DVC) using glass micropipettes. Swallowing was induced by repeated electrical stimulation of the central cut end of the superior laryngeal nerve (SLN) and was identified by the electromyogram lead penetrated in the mylohyoide muscle through bipolar electrodes. Microinjection of GLP-1 into the medial DVC (M-DVC) increased the frequency of swallowing during the electrical stimulation of the SLN and extended the latency of the first swallowing...
July 7, 2017: Brain Research
https://www.readbyqxmd.com/read/28690686/vagus-nerve-stimulation-as-a-potential-adjuvant-to-behavioral-therapy-for-autism-and-other-neurodevelopmental-disorders
#18
REVIEW
Crystal T Engineer, Seth A Hays, Michael P Kilgard
BACKGROUND: Many children with autism and other neurodevelopmental disorders undergo expensive, time-consuming behavioral interventions that often yield only modest improvements. The development of adjunctive interventions that can increase the benefit of rehabilitation therapies is essential in order to improve the lives of individuals with neurodevelopmental disorders. MAIN TEXT: Vagus nerve stimulation (VNS) is an FDA approved therapy that is safe and effective in reducing seizure frequency and duration in individuals with epilepsy...
2017: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/28688875/diagnostic-surgical-and-postoperative-challenges-of-neuroendocrine-tumors-of-the-neck-clinical-experience-and-literature-review
#19
Mohammad Mussadaq Khan, Mohammad Iqbal Khan, Hussan Ali, Tehreem Kazmi, Hania Iqbal
BACKGROUND: Neuroendocrine tumors of the neck are rare swellings, which constitute about 0.03% of all tumors. Most are sporadically arising paragangliomas. Over 50% arise from the carotid bodies and pose difficulties in diagnosis and surgical management, which may result in disabling complications. OBJECTIVE: To determine the diagnostic, surgical and postoperative challenges, and how to overcome them, in the management of neuroendocrine tumors of the neck. STUDY DESIGN: Descriptive case series...
July 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28685024/bugs-guts-and-brains-and-the-regulation-of-food-intake-and-body-weight
#20
REVIEW
M K Hamilton, H E Raybould
The microbiota-gut-brain axis is currently being explored in many types of rodent models, including models of behavioral, neurodegenerative and metabolic disorders. Our laboratory is interested in determining the mechanisms and consequences of activation of vagal afferent neurons that lead to activation of parasympathetic reflexes and changes in feeding behavior in the context of obesity. Obesity is associated with microbial dysbiosis, decreased intestinal barrier function, gut inflammation, metabolic endotoxemia, chronic low-grade systemic inflammation and desensitization of vagal afferent nerves...
December 2016: International Journal of Obesity Supplements
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