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https://www.readbyqxmd.com/read/29033929/immunity-and-fibrogenesis-the-role-of-th17-il-17-axis-in-hbv-and-hcv-induced-chronic-hepatitis-and-progression-to-cirrhosis
#1
REVIEW
Feliciano Chanana Paquissi
Cirrhosis is a common final pathway for most chronic liver diseases; representing an increasing burden worldwide and is associated with increased morbidity and mortality. Current evidence has shown that, after an initial injury, the immune response has a significant participation in the ongoing damage, and progression from chronic viral hepatitis (CVH) to cirrhosis, driving the activation and maintenance of main fibrogenic pathways. Among immune deregulations, those related to the subtype 17 of T helper lymphocytes (Th17)/interleukin-17 (IL-17) axis have been recognized as key immunopathological and prognostic elements in patients with CVH...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29027728/hepatitis-in-aids-patients
#2
REVIEW
Muhammad Imran Qadir
The individuals with HIV infection are more susceptible to develop coinfections with infectious pathogens such as HCV and HBV. The routes of transmission of these pathogens are the same including sexual contact, injection drug use, or at birth from mother to an infant. The main reason of morbidity and mortality in HIV infected individuals is a liver disease in the context of antiretroviral therapy, and coinfection such as HCV and HBV complicates this condition. Nucleos(t)ide analogues are used for HBV infection management, and treatment of HCV infection is done by PegIFN and ribavirin combination and protease inhibitors...
October 13, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29026129/hepatitis-virus-infection-and-age-related-cataract
#3
Sangshin Park, Nam-Kyong Choi
This study was performed to investigate the relationships of hepatitis B (HBV) and hepatitis C virus (HCV) infection to age-related cataract, and to assess whether liver damage mediates the hepatitis-cataract association. This study analyzed data in the Korea National Health and Nutrition Examination Survey 2010-2012 on 10,037 participants aged ≥40 years. We performed mediation analysis to address the contribution of serum markers of liver damage, high aspartate (AST, >49.9 IU/L) and alanine aminotransferase (ALT, >56...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29023927/hepatitis-b-virus-dual-infection-disrupts-platelet-count-recovery-in-chronic-hepatitis-c-patients-with-curative-antiviral-therapy
#4
Chung-Feng Huang, Ming-Lun Yeh, Ching-I Huang, Zu-Yau Lin, Shinn-Cherng Chen, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Ming-Lung Yu
BACKGROUND/AIMS: Hepatitis C virus (HCV) infection is associated with thrombocytopenia. Thrombocytopenia recovers after viral eradication. The current study explored the rate and factors associated with platelet (PLT) recovery, which may represent the degree of liver fibrosis regression. METHODS: A total of 466 patients who achieved a sustained virological response (SVR) were enrolled to compare the PLT change after a mean follow-up period of 85.5months (range 12-163 months)...
October 11, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29020289/a-novel-human-pegivirus-hpgv-2-hhpgv-1-is-tightly-associated-with-hcv-infection-and-hcv-hiv-1-co-infection
#5
Haiying Wang, Zhengwei Wan, Ru Xu, Yujuan Guan, Nalin Zhu, Jianping Li, Zhiwei Xie, Aiqi Lu, Fuchun Zhang, Yongshui Fu, Shixing Tang
Background: HPgV-2 is a novel blood-borne human pegivirus that mainly infects HCV-infected subjects. We have investigated the prevalence of HPgV-2 in China, its association with HCV and HIV-1, and the impact on HCV viral load and liver damage. Methods: A cross-sectional study was conducted with both blood donors and HCV- and HIV-1-infected patients in Guangzhou, China. All subjects were screened for antiHPgV-2 and HPgV-2 RNA. Demographic and clinical information were obtained from electronic medical records...
August 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29016628/hazardous-air-pollutants-and-primary-liver-cancer-in-texas
#6
Luca Cicalese, Giuseppe Curcuru, Mauro Montalbano, Ali Shirafkan, Jeremias Georgiadis, Cristiana Rastellini
The incidence of hepatocellular carcinoma (HCC), the most common primary liver cancer, is increasing in the US and tripled during the past two decades. The reasons for such phenomenon remain poorly understood. Texas is among continental states with the highest incidence of liver cancer with an annual increment of 5.7%. Established risk factors for HCC include Hepatitis B and C (HBV, HCV) viral infection, alcohol, tobacco and suspected risk factors include obesity and diabetes. While distribution of these risk factors in the state of Texas is similar to the national data and homogeneous, the incidence of HCC in this state is exceptionally higher than the national average and appears to be dishomogeneous in various areas of the state suggesting that other non-recognized risk factors might play a role...
2017: PloS One
https://www.readbyqxmd.com/read/29016470/efficacy-of-branched-chain-amino-acid-supplementation-and-walking-exercise-for-preventing-sarcopenia-in-patients-with-liver-cirrhosis
#7
Atsushi Hiraoka, Kojiro Michitaka, Daisuke Kiguchi, Hirofumi Izumoto, Hidetaro Ueki, Miho Kaneto, Shogo Kitahata, Toshihiko Aibiki, Tomonari Okudaira, Hideomi Tomida, Yuji Miyamoto, Hiroka Yamago, Yoshifumi Suga, Ryuichiro Iwasaki, Kenichiro Mori, Hideki Miyata, Eiji Tsubouchi, Masato Kishida, Tomoyuki Ninomiya, Shigeru Kohgami, Masashi Hirooka, Yoshio Tokumoto, Masanori Abe, Bunzo Matsuura, Yoichi Hiasa
BACKGROUND/AIM: Sarcopenia is recognized as a condition related to quality of life and prognosis in patients with chronic liver disease, although no useful strategy for improving muscle volume and strength has been established. Here, we evaluated the efficacy of supplementation with branched-chain amino acid (BCAA) administration and walking exercise. PATIENTS AND METHODS: From December 2015 to July 2016, 33 Japanese outpatients with liver cirrhosis were enrolled (median: 67 years, HCV : HBV : alcohol : others=26 : 2 : 2 : 3, male : female=13 : 20, Child-Pugh A : B=30 : 3)...
October 9, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28994127/the-negative-impact-of-hbv-hcv-coinfection-on-cirrhosis-and-its-consequences
#8
S Pol, G Haour, H Fontaine, C Dorival, V Petrov-Sanchez, M Bourliere, J Capeau, P Carrieri, D Larrey, C Larsen, P Marcellin, J-M Pawlostky, P Nahon, F Zoulim, P Cacoub, V de Ledinghen, P Mathurin, F Negro, G-P Pageaux, Y Yazdanpanah, L Wittkop, J-P Zarski, F Carrat
BACKGROUND: Hepatitis B virus (HBV)/hepatitis C virus (HCV) confection has been rarely studied in nonasian series. AIM: To compare the characteristics of HBV/HCV coinfected patients to those of HBV- or HCV-monoinfected patients in the ANRS CO22 HEPATHER cohort study. PATIENTS AND METHODS: Of the 20 936 included patients, 95 had HBV/HCV coinfection (hepatitis B surface antigen, anti-HCV antibody and HCV RNA positive) and were matched with 375 HBV- and 380 HCV-monoinfected patients on age, gender and time since HBV or HCV diagnosis...
October 9, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28991180/robust-regression-analysis-of-gcms-data-reveals-differential-rewiring-of-metabolic-networks-in-hepatitis-b-and-c-patients
#9
Cedric Simillion, Nasser Semmo, Jeffrey R Idle, Diren Beyoğlu
About one in 15 of the world's population is chronically infected with either hepatitis virus B (HBV) or C (HCV), with enormous public health consequences. The metabolic alterations caused by these infections have never been directly compared and contrasted. We investigated groups of HBV-positive, HCV-positive, and uninfected healthy controls using gas chromatography-mass spectrometry analyses of their plasma and urine. A robust regression analysis of the metabolite data was conducted to reveal correlations between metabolite pairs...
October 8, 2017: Metabolites
https://www.readbyqxmd.com/read/28987047/-epidemiology-and-risk-factors-of-hepatocellular-carcinoma
#10
REVIEW
Agnieszka Budny, Piotr Kozłowski, Marzena Kamińska, Małgorzata Jankiewicz, Agnieszka Kolak, Bożena Budny, Witold Budny, Joanna Niemunis-Sawicka, Grzegorz Szczypiór, Bartosz Kurniawka, Franciszek Burdan
Primary liver neoplasms occurs relatively rarely in Poland. The most frequently occurring type of cancer is hepatocellular carcinoma (HCC), which globally constitutes 7% of all the occurrences of cancer. The incidence increases with age and is the highest in patients around the age of 70. It also varies significantly depending on the geographic location. The main factors that cause HCC are infection of HBV and HCV, whose genome integrates into the DNA of the host, causing mutations. The other factors include excessive alcohol consumption, contact or consumption of Aspergillus toxins as well as various metabolic disorders, such as α1-antitrypsin deficiency, hemochromatosis, tyrosinemia, porphyria, von Gierke disease and in person with gene mutation p...
September 29, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28983565/the-burden-of-primary-liver-cancer-and-underlying-etiologies-from-1990-to-2015-at-the-global-regional-and-national-level-results-from-the-global-burden-of-disease-study-2015
#11
Tomi Akinyemiju, Semaw Abera, Muktar Ahmed, Noore Alam, Mulubirhan Assefa Alemayohu, Christine Allen, Rajaa Al-Raddadi, Nelson Alvis-Guzman, Yaw Amoako, Al Artaman, Tadesse Awoke Ayele, Aleksandra Barac, Isabela Bensenor, Adugnaw Berhane, Zulfiqar Bhutta, Jacqueline Castillo-Rivas, Abdulaal Chitheer, Jee-Young Choi, Benjamin Cowie, Lalit Dandona, Rakhi Dandona, Subhojit Dey, Daniel Dicker, Huyen Phuc, Donatus U Ekwueme, Maysaa El Sayed Zaki, Florian Fischer, Thomas Fürst, Jamie Hancock, Simon I Hay, Peter Hotez, Sun Ha Jee, Amir Kasaeian, Yousef Khader, Young-Ho Khang, G Anil Kumar, Michael Kutz, Heidi Larson, Alan Lopez, Raimundas Lunevicius, Reza Malekzadeh, Colm McAlinden, Toni Meier, Walter Mendoza, Ali Mokdad, Maziar Moradi-Lakeh, Gabriele Nagel, Quyen Nguyen, Grant Nguyen, Felix Ogbo, George Patton, David M Pereira, Farshad Pourmalek, Mostafa Qorbani, Amir Radfar, Gholamreza Roshandel, Joshua A Salomon, Juan Sanabria, Benn Sartorius, Maheswar Satpathy, Monika Sawhney, Sadaf Sepanlou, Katya Shackelford, Hirbo Shore, Jiandong Sun, Desalegn Tadese Mengistu, Roman Topór-Madry, Bach Tran, Kingsley Nnanna Ukwaja, Vasiliy Vlassov, Stein Emil Vollset, Theo Vos, Tolassa Wakayo, Elisabete Weiderpass, Andrea Werdecker, Naohiro Yonemoto, Mustafa Younis, Chuanhua Yu, Zoubida Zaidi, Liguo Zhu, Christopher J L Murray, Mohsen Naghavi, Christina Fitzmaurice
Importance: Liver cancer is among the leading causes of cancer deaths globally. The most common causes for liver cancer include hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and alcohol use. Objective: To report results of the Global Burden of Disease (GBD) 2015 study on primary liver cancer incidence, mortality, and disability-adjusted life-years (DALYs) for 195 countries or territories from 1990 to 2015, and present global, regional, and national estimates on the burden of liver cancer attributable to HBV, HCV, alcohol, and an "other" group that encompasses residual causes...
October 5, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28981193/organ-utilization-from-increased-infectious-risk-donors-an-observational-study
#12
Arnaud G L'Huillier, Atul Humar, Clare Payne, Deepali Kumar
BACKGROUND: Donors with an increased risk of transmitting human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV) (increased risk donors [IRDs]) are a potential source of organs for transplant. Organs from IRDs can be utilized with appropriate recipient consent and post-transplant follow-up. We reviewed the characteristics and utilization of IRDs in our Organ Procurement Organization (OPO) over a 2-year period. METHODS: Donor information from April 1, 2013 to March 31, 2015 was obtained through the OPO database...
October 5, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28968953/brip1-coding-variants-are-associated-with-a-high-risk-of-hepatocellular-carcinoma-occurrence-in-patients-with-hcv-or-hbv-related-liver-disease
#13
Abderrahim Oussalah, Patrice Hodonou Avogbe, Erwan Guyot, Céline Chery, Rosa-Maria Guéant-Rodriguez, Nathalie Ganne-Carrié, Aurélie Cobat, Darius Moradpour, Bertrand Nalpas, Francesco Negro, Thierry Poynard, Stanislas Pol, Pierre-Yves Bochud, Laurent Abel, Hélène Jeulin, Evelyne Schvoerer, Nicodème Chabi, Emile Amouzou, Ambaliou Sanni, Hélène Barraud, Pierre Rouyer, Thomas Josse, Laetitia Goffinet, Jean-Louis Jouve, Anne Minello, Claire Bonithon-Kopp, Gérard Thiefin, Vincent Di Martino, Michel Doffoël, Carine Richou, Jean-Jacques Raab, Patrick Hillon, Jean-Pierre Bronowicki, Jean-Louis Guéant
The molecular mechanisms of hepatocellular carcinoma (HCC) carcinogenesis are still not fully understood. DNA repair defects may influence HCC risk. The aim of the study was to look for potential genetic variants of DNA repair genes associated with HCC risk among patients with alcohol- or viral-induced liver disease. We performed four case-control studies on 2,006 European- (Derivation#1 and #2 studies) and African-ancestry (Validation#1 and #2 studies) patients originating from several cohorts in order to assess the association between genetic variants on DNA repair genes and HCC risk using a custom array encompassing 94 genes...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28968772/mucosal-associated-invariant-t-mait-cells-are-more-activated-in-chronic-hepatitis-b-but-not-depleted-in-blood-reversal-by-antiviral-therapy
#14
Lauke L Boeijen, Noé R Montanari, Rik A de Groen, Gertine W van Oord, Marieke van der Heide-Mulder, Robert J de Knegt, André Boonstra
Background: Mucosal-Associated Invariant T cells (MAIT cells) might play a role in control of viral replication during chronic hepatitis B (cHBV) infection, but little is known of their number, phenotype or function in cHBV patients. Methods: We performed flow cytometry on CD3+Vɑ7.2+CD161+ MAIT cells in blood of 55 cHBV patients. Nine patients were sampled before and on entecavir treatment. Six patients on therapy underwent a liver biopsy for flow cytometric analysis...
August 23, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28966070/prevalence-of-occult-hepatitis-b-virus-infection-and-torque-teno-virus-infection-and-their-association-with-hepatocellular-carcinoma-in-chronic-hepatitis-c-patients
#15
Agatha S Rosa, Oscar C Araujo, Flavia Savassi-Ribas, Carlos A Fernandes, Henrique S Coelho, Christian Niel, Cristiane A Villela-Nogueira, Natalia M Araujo
BACKGROUND: The role of occult hepatitis B virus (HBV) infection and Torque teno virus (TTV) infection in the development of hepatocellular carcinoma (HCC) in chronic hepatitis C patients is still uncertain. AIM: The aim of the present study was to investigate the prevalence and significance of OBI and TTV infection, and to examine the genetic diversity of these viruses, in chronic hepatitis C patients with and without HCC. METHODS: Sera from 151 hepatitis C virus (HCV)-infected patients (49 patients with HCC and 102 without HCC) negative for HBV surface antigen (HBsAg) were tested for the presence of OBI and TTV infection by semi-nested and group-specific multiplex PCR assays, respectively...
September 29, 2017: Virus Research
https://www.readbyqxmd.com/read/28960360/survival-after-treatment-with-curative-intent-for-hepatocellular-carcinoma-among-patients-with-vs-without-non-alcoholic-fatty-liver-disease
#16
C R Wong, B Njei, M H Nguyen, A Nguyen, J K Lim
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is expected to become a leading aetiology of hepatocellular carcinoma (HCC)-related mortality in the United States. HCC treatments with curative intent (OLT, orthotopic liver transplantation; resection; RFA, radiofrequency ablation) can improve survival in carefully selected patients. AIM: To compare survival after receipt of curative treatment for NAFLD and non-NAFLD-HCC aetiologies (HCV, chronic hepatitis C; HBV, chronic hepatitis B; ALD, alcoholic liver disease) and by treatment was performed...
September 28, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28951779/cd4-t-cells-and-natural-killer-cells-biomarkers-for-hepatic-fibrosis-in-human-immunodeficiency-virus-hepatitis-c-virus-coinfected-patients
#17
Natalia Laufer, Diego Ojeda, María Laura Polo, Ana Martinez, Héctor Pérez, Gabriela Turk, Pedro Cahn, Norberto Walter Zwirner, Jorge Quarleri
AIM: To characterize peripheral blood natural killer (NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients. METHODS: Peripheral mononuclear cells from 24 HIV/HCV (HBV negative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4...
September 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28951598/prevalence-and-predictors-of-liver-disease-in-hiv-infected-children-and-adolescents
#18
Maria Pokorska-Śpiewak, Aleksandra Stańska-Perka, Jolanta Popielska, Agnieszka Ołdakowska, Urszula Coupland, Konrad Zawadka, Małgorzata Szczepańska-Putz, Magdalena Marczyńska
Liver disease in HIV-infected patients may result from the infection itself, antiretroviral treatment or comorbidities. In this study, we analysed liver disease in 79 HIV-infected children and adolescents aged 14.0 ± 5.1 years. All the patients were receiving combination antiretroviral therapy (cART), with a mean duration of 11.5 ± 4.7 years. Six patients (8%) had detectable HIV viral load, and 8/79 (10%) of the participants were coinfected with hepatitis B or C virus (HCV, 6/8 or HBV, 2/8). Liver disease was defined as an elevation of any of the following parameters: alanine or aspartate aminotransferase (ALT and AST), total bilirubin, and gamma glutamyl transferase (GGTP)...
September 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28946631/alcohol-misuse-link-to-poems-syndrome-in-a-patient
#19
John Neary, Susan E Goodwin, Lawrence B Cohen, Manuela G Neuman
Previously called Crow-Fukase syndrome, POEMS syndrome is characterized by poly-neuropathy, osteo-sclerotic myeloma, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes. Extremely elevated levels of serum vascular endothelial growth factor (VEGF) are characteristic of the syndrome. Chronic hepatitis B (HBV) and C (HCV) infections can also be present in POEMS. The pathogenesis of the syndrome is not well understood. The link between chronic alcohol consumption and this malignant condition has not been reported until now...
September 23, 2017: Cancers
https://www.readbyqxmd.com/read/28935244/contribution-of-hepatitis-b-virus-and-hepatitis-c-virus-to-liver-cancer-in-china-north-areas-experience-of-the-chinese-national-cancer-center
#20
Minjie Wang, Yuting Wang, Xiaoshuang Feng, Ruijun Wang, Yanmei Wang, Hongmei Zeng, Jun Qi, Hong Zhao, Ni Li, Jianqiang Cai, Chunfeng Qu
INTRODUCTION: The aim of this study was to determine the impact of hepatitis B virus (HBV) and/or hepatitis C virus (HCV) on primary liver cancer (PLC) in China north areas. METHODS: A total of 2172 histologically confirmed PLC patients attending the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences during the period January 1, 2003 to December 31, 2014 were enrolled. Details of hepatitis B surface antigen (HBsAg), antibodies against HBV core antigen (anti-HBc), and antibodies against HCV (anti-HCV) status were recorded...
September 19, 2017: International Journal of Infectious Diseases: IJID
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