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https://www.readbyqxmd.com/read/28804513/noncirrhotic-hepatocellular-carcinoma-etiology-and-occult-hepatitis-b-virus-infection-in-a-hepatitis-b-virus-endemic-area
#1
Chang Woo Shim, Joong-Won Park, So Hee Kim, Jin Sook Kim, Bo Hyun Kim, Sung Hoon Kim, Eun Kyung Hong
BACKGROUND: Although hepatocellular carcinoma (HCC) usually develops in cirrhotic livers, a minority of cases occur in noncirrhotic livers (NCLs). We investigated etiology, clinicopathological features, and occult hepatitis B virus (HBV) infection (OBI) in patients with NCL HCC in an HBV-endemic area. METHODS: A total of 710 patients who underwent resection or transplantation for HCC at the National Cancer Center (NCC), Korea, were enrolled. HCC and fibrosis stage were diagnosed pathologically...
July 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28800545/liver-toxicity-of-chemotherapy-and-targeted-therapy-for-breast-cancer-patients-with-hepatitis-virus-infection
#2
Yu Liu, Zhan-Yi Li, Xi Li, Jia-Ni Wang, Qun-Ai Huang, Yong Huang
BACKGROUND: Chemotherapy has greatly improved the prognosis of breast cancer patients. However, it may also result in undesirable side effects such as hepatitis virus reactivation. Little information is available on the liver toxicity of chemotherapy and targeted therapy for breast cancer patients with hepatitis virus (HBV/HCV) infection. METHODS: We performed a retrospective survey of 835 patients diagnosed with breast cancer between January 2010 and December 2015 at our institution...
August 8, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28797080/physician-perspectives-on-the-management-of-viral-hepatitis-and-hepatocellular-carcinoma-in-myanmar
#3
Yoona A Kim, Sam Trinh, Si Thura, Khin Pyone Kyi, Thomas Lee, Stan Sze, Adam Richards, Andrew Aronsohn, Grace L H Wong, Yasuhito Tanaka, Geoffrey Dusheiko, Mindie H Nguyen
BACKGROUND: In Myanmar, over five million people are infected with hepatitis B virus (HBV) and hepatitis C virus (HCV). Hepatitis has been a recent focus with the development of a National Strategic Plan on Hepatitis and plans to subsidize HCV treatment. METHODS: During a two-day national liver disease symposium covering HCV, HBV, hepatocellular (HCC), and end-stage liver disease (ESLD), physician surveys were administered using the automated response system (ARS) to assess physician knowledge, perceptions of barriers to screening and treatment, and proposed solutions...
2017: PloS One
https://www.readbyqxmd.com/read/28783179/reciprocal-antagonism-between-the-netrin-1-receptor-uncoordinated-phenotype-5a-unc5a-and-the-hepatitis-c-virus
#4
M-L Plissonnier, T Lahlali, M Raab, M Michelet, C Romero-López, M Rivoire, K Strebhardt, D Durantel, M Levrero, P Mehlen, F Zoulim, R Parent
Hepatitis C virus (HCV) infection is a leading cause of hepatocellular carcinoma (HCC), mainly through cirrhosis induction, spurring research for a deeper understanding of HCV versus host interactions in cirrhosis. The present study investigated crosstalks between HCV infection and UNC5A, a netrin-1 dependence receptor that is inactivated in cancer. UNC5A and HCV parameters were monitored in patients samples (n=550) as well as in in vitro. In patients, UNC5A mRNA expression is significantly decreased in clinical HCV(+) specimens irrespective of the viral genotype, but not in (HBV)(+) liver biopsies, as compared to uninfected samples...
August 7, 2017: Oncogene
https://www.readbyqxmd.com/read/28774413/management-of-hepatitis-b-in-special-populations
#5
REVIEW
Kali Zhou, Norah Terrault
Special populations infected with chronic HBV include those with decompensated cirrhosis, coinfections (HIV, HCV, HDV), hemodialysis and renal failure, immunosuppressed including transplant patients, children and women in pregnancy. These populations differ in their natural history and risk for liver-related complications, the indications for anti-HBV therapy as well as the recommendations regarding the HBV drugs used, duration of therapy and anticipated endpoints. Reflecting the special populations with substantive changes in management in recent years, this review focuses on HBV-HIV coinfected patients, immunosuppressed patients at risk for reactivation, liver transplant recipients and pregnant women...
June 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28770001/interleukin-17f-expression-is-elevated-in-hepatitis-c-patients-with-fibrosis-and-hepatocellular-carcinoma
#6
Ming-Sian Wu, Chun-Hsiang Wang, Fan-Chen Tseng, Hsuan-Ju Yang, Yin-Chiu Lo, Yi-Ping Kuo, De-Jiun Tsai, Wan-Ting Tsai, Guann-Yi Yu
BACKGROUND: The role of interleukin (IL) 17A in chronic liver diseases had been extensively studied, but the function of IL-17F, which shares a high degree of homology with IL-17A, in the progression of chronic hepatic diseases is poorly understood. The aim of the study was to evaluate the association between IL-17F and liver diseases including, fibrosis and hepatocellular carcinoma (HCC). METHODS: Hepatic tumor samples from both hepatitis C virus (HCV) positive and negative patients (without HBV and HCV, NBNC) were examined with quantitative PCR and immunohistochemistry staining for inflammatory cytokine genes expression...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28763858/-the-comparison-of-liver-inflammation-and-fibrosis-between-chronic-hbv-and-hcv-infection
#7
L Wang, Y X Fan, Y Ding, Q J Sheng, C Zhang, L R Zhao, T T Xia, Z Y An, H Bai, H Y Shi, X G Dou
Objective: To explore the difference of liver inflammation and fibrosis in patients with chronic hepatitis B virus (HBV) infection and chronic hepatitis C virus (HCV) infection, and to investigate the relationship between hepatic pathology and alanine aminotransferase (ALT). Methods: 57 patients with chronic HCV infection and 346 patients with chronic HBV infection who were hospitalized at Shengjing Hospital of China Medical University from January 2012 to September 2016 were enrolled. In chronic HBV infection, including 88 cases whose ALT were more than two times of upper limited of normal (ALT≥2×ULN) and 258 cases whose ALT were less than two times of upper limited of normal (ALT < 2×ULN)...
June 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28763497/diagnosis-of-coinfection-by-schistosomiasis-and-viral-hepatitis-b-or-c-using-1h-nmr-based-metabonomics
#8
Liana Ribeiro Gouveia, Joelma Carvalho Santos, Ronaldo Dionísio Silva, Andrea Dória Batista, Ana Lúcia Coutinho Domingues, Edmundo Pessoa de Almeida Lopes, Ricardo Oliveira Silva
BACKGROUND: Diagnosis of liver involvement due to schistosomiasis in asymptomatic patients from endemic areas previously diagnosed with chronic hepatitis B (HBV) or C (HCV) and periportal fibrosis is challenging. H-1 Nuclear Magnetic Resonance (NMR)-based metabonomics strategy is a powerful tool for providing a profile of endogenous metabolites of low molecular weight in biofluids in a non-invasive way. The aim of this study was to diagnose periportal fibrosis due to schistosomiasis mansoni in patients with chronic HBV or HCV infection through NMR-based metabonomics models...
2017: PloS One
https://www.readbyqxmd.com/read/28754847/clinical-study-on-the-relationship-between-hepatitis-b-virus-infection-and-risk-of-breast-cancer-a-large-sized-case-control-and-single-center-study-in-southwest-of-china
#9
Lin-Jie Lu, Vishnu Prasad Adhikari, Chun-Xia Zhao, He Wu, Wei Dai, Xin Li, Hong-Yuan Li, Guo-Sheng Ren, Kai-Nan Wu, Ling-Quan Kong
PURPOSE: Chronic hepatitis C virus (HCV) infection is reported to be associated with early-onset breast cancer, while, as a hepadnavirus, hepatitis B virus(HBV) infection is more common than HCV in China. In this article, it is aimed to study the relationship between HBV infection and risk of breast cancer in China. METHODS: The clinical data of 2452 cases of initially diagnosed breast cancer and 1926 cases of benign breast disease (as controls) with the consecutive reports of HBV serological markers and liver function tests, available in the Electronic Medical Records of the Breast Cancer Center of Chongqing, the southwest of China, from January 2011 to March 2015, were collected for analysis...
July 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28750484/reactivation-of-hepatitis-c-virus-and-its-clinical-outcomes-in-patients-treated-with-systemic-chemotherapy-or-immunosuppressive-therapy
#10
Hae Lim Lee, Si Hyun Bae, Bohyun Jang, Seawon Hwang, Hyun Yang, Hee Chul Nam, Pil Soo Sung, Sung Won Lee, Jeong Won Jang, Jong Young Choi, Nam Ik Han, Byung Joo Song, Jong Wook Lee, Seung Kew Yoon
Background/Aims: According to the results of several studies, the outcome of hepatitis C virus (HCV) reactivation is not as severe as the outcome of hepatitis B virus (HBV) reactivation. The aim of this study was to evaluate the effect of pharmacological immunosuppression on HCV reactivation. Methods: The medical records of patients who underwent systemic chemotherapy, corticosteroid therapy, or other immunosuppressive therapies between January 2008 and March 2015 were reviewed...
July 28, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28748878/assessment-of-hepatic-fibrosis-by-fibroscan-in-egyptian-chronic-hemodialysis-patients-with-chronic-hepatitis-c-genotype-4-a-single-center-study
#11
Bahaa El-Din Moustafa Zayed, Aisha Elsharkawy, Mahmoud Abdou, Dina Sabry Abd Al Fatah, Tarek Hussein El-Shabony
Assessing hepatic fibrosis in hemodialysis patients with chronic hepatitis C (CHC) can help to evaluate the long-term prognosis, complications of hepatitis C virus (HCV) as well as eligibility for renal transplantation,. Our aim was to assess liver fibrosis in Egyptian hemodialysis (HD) patients infected with CHC genotype 4 using a fibroscan. This cross-sectional observational study was conducted over two years on a cohort of 134 Egyptian patients on prevalent HD at Kasr Al Ainy Hospital. All patients were subjected to routine laboratory evaluation including, hepatitis B surface antigen, hepatitis B core antibody, hepatitis Be antigen, hepatitis C antibody (HCVAb) and human immunodeficiency virus antibody, quantitative polymerase chain reaction (PCR) for both HCV and hepatitis B virus (HBV), serum hyaluronic acid level, and alpha-fetoprotein (AFP)...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28716576/tlr9-mediated-conditioning-of-liver-environment-is-essential-for-successful-intrahepatic-immunotherapy-and-effective-memory-recall
#12
Marcin Cebula, Mathias Riehn, Upneet Hillebrand, Ramona F Kratzer, Florian Kreppel, Georgia Koutsoumpli, Toos Daemen, Hansjörg Hauser, Dagmar Wirth
Immune defense against hepatotropic viruses such as hepatitis B (HBV) and hepatitis C (HCV) poses a major challenge for therapeutic approaches. Intrahepatic cytotoxic CD8 T cells that are crucial for an immune response against these viruses often become exhausted resulting in chronic infection. We elucidated the T cell response upon therapeutic vaccination in inducible transgenic mouse models in which variable percentages of antigen-expressing hepatocytes can be adjusted, providing mosaic antigen distribution and reflecting the varying viral antigen loads observed in patients...
July 14, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28715695/new-liver-cancer-biomarkers-pi3k-akt-mtor-pathway-members-and-eukaryotic-translation-initiation-factors
#13
Nicole Golob-Schwarzl, Stefanie Krassnig, Anna M Toeglhofer, Young Nyun Park, Margit Gogg-Kamerer, Klemens Vierlinger, Fabian Schröder, Hyungjn Rhee, Rudolf Schicho, Peter Fickert, Johannes Haybaeck
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. The initiation of protein translation is an important rate-limiting step in eukaryotes and is crucial in many viral infections. Eukaryotic translation initiation factors (eIFs) are involved in the initiation step of protein translation and are linked to the phosphatidylinositol-3-kinases PI3K/AKT/mTOR pathway. Therefore we aimed to investigate a potential role of eIFs in HCC. We herein report on the immunohistochemical expression of the various eIF subunits in 235 cases of virus-related human HCC...
July 14, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28711626/influence-of-metabolic-risk-factors-on-risk-of-hepatocellular-carcinoma-and-liver-related-death-in-men-with-chronic-hepatitis-b-a-large-cohort-study
#14
Ming-Whei Yu, Chih-Lin Lin, Chun-Jen Liu, Shu-Han Yang, Yu-Lin Tseng, Chih-Feng Wu
BACKGROUND & AIMS: Little is known about the absolute risk of hepatocellular carcinoma (HCC) and liver-disease related death, in association with metabolic risk factors, for patients with hepatitis B virus (HBV) infection. METHODS: We collected data from 5373 male Taiwanese civil servants who visited Taiwan's Government Employees' Central Clinics and received routine free physical examinations from 1989 through 1992. We obtained information on liver-related morbidity and mortality in HBV carriers, 40-65 years old (n=1690), with different metabolic risk factors...
July 12, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28710825/associations-of-antibody-to-hepatitis-b-core-antigen-positivity-with-outcomes-in-hepatocellular-carcinoma-patients-undergoing-hepatic-resection
#15
Shinji Itoh, Tomoharu Yoshizumi, Takahiro Tomino, Akihisa Nagatsu, Takashi Motomura, Noboru Harada, Norifumi Harimoto, Toru Ikegami, Yuji Soejima, Yoshihiko Maehara
AIM: We aimed to evaluate the effect of antibody to hepatitis B core antigen (HBcAb)-positivity on the clinical outcomes after hepatic resection in hepatocellular carcinoma (HCC) patients with negative hepatitis B surface antigen (HBsAg) and hepatitis C virus antibody (HCVAb), termed non-B, non-C HCC (NBNC-HCC), or with HCV-related HCC. METHODS: Two hundred sixty-three patients who underwent hepatic resection for HCC and measurements of HBsAg, HCVAb, and HBcAb were enrolled in this study...
July 15, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28701893/risk-assessment-of-hepatocellular-carcinoma-in-general-population-by-liver-stiffness-in-combination-with-controlled-attenuation-parameter-using-transient-elastography-a-cross-sectional-study
#16
Takaaki Sugihara, Masahiko Koda, Tomomitsu Matono, Kinya Okamoto, Yoshikazu Murawaki, Hajime Isomoto, Shiho Tokunaga
BACKGROUND: Hepatocellular carcinoma (HCC) in patients without hepatitis B (HBV) and -C virus (HCV) infection are increasing in Japan. Method for detecting high-risk liver diseases of HCC in general population has still not been established. Liver stiffness measurement (LSM) and Controlled Attenuation Parameter (CAP) using transient elastography (TE; FibroScan System) are useful for detecting liver fibrosis and steatosis. The aim of this study is to clarify TE for risk assessment of HCC in general population...
June 2017: Yonago Acta Medica
https://www.readbyqxmd.com/read/28691411/kupffer-cell-in-the-immune-activation-and-tolerance-toward-hbv-hcv-infection
#17
REVIEW
Yuan Fangchao, Zhang Wenfeng, Mu Di, Gong Jianping
Kupffer cells(KCs) largely found in the sinusoids are the macrophages which specifically reside in liver. KC is a crucial part of innate immune system, acting as scavenger and phagocyte. KCs and sinusoidal endothelial cells together form the first immune barrier of the portal system. Studies show that KCs can not only maintain homeostasis in immune response, but also facilitate the pathogenesis of type B and type C hepatitis through their antigen-presenting function and secretion of soluble mediators. KCs can express TLRs (Toll-like receptors), FasL, Programmed cell death ligand 1 (PD-L1) and secrete large amount of inflammatory factors to lead to the tolerant state of immune response toward HBV/HCV...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28686707/molecular-characterization-of-occult-hepatitis-b-virus-infection-in-patients-with-end-stage-liver-disease-in-colombia
#18
Julio Cesar Rendon, Fabian Cortes-Mancera, Juan Carlos Restrepo-Gutierrez, Sergio Hoyos, Maria-Cristina Navas
BACKGROUND: Hepatitis B virus (HBV) occult infection (OBI) is a risk factor to be taken into account in transfusion, hemodialysis and organ transplantation. The aim of this study was to identify and characterize at the molecular level OBI cases in patients with end-stage liver disease. METHODS: Sixty-six liver samples were obtained from patients with diagnosis of end-stage liver disease submitted to liver transplantation in Medellin (North West, Colombia). Samples obtained from patients who were negative for the surface antigen of HBV (n = 50) were tested for viral DNA detection by nested PCR for ORFs S, C, and X and confirmed by Southern-Blot...
2017: PloS One
https://www.readbyqxmd.com/read/28684103/late-hepatitis-b-and-c-diagnosis-in-relation-to-disease-decompensation-and-hepatocellular-carcinoma-development
#19
Hasina Samji, Amanda Yu, Margot Kuo, Maryam Alavi, Ryan Woods, Maria Alvarez, Gregory J Dore, Mark Tyndall, Mel Krajden, Naveed Z Janjua
BACKGROUND AND AIMS: We measured the timing of HBV and HCV diagnoses relative to detection of decompensated cirrhosis (DC) and hepatocellular carcinoma (HCC) as an indicator of late hepatitis diagnosis. METHODS: HBV and HCV diagnoses were defined relative to the diagnosis of DC or HCC such that HBV/HCV diagnoses within two years prior, at the time of or after HCC or DC diagnosis were considered late. We performed multivariable logistic regression to assess factors associated with late HBV/HCV diagnoses among those with DC or HCC...
July 3, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28679981/compliance-and-problems-with-the-surveillance-program-for-hcc-diagnosis
#20
Jun-Ichi Okano, Yukako Matsuki, Ran Nagahara, Masashi Yamane, Toshiaki Okamoto, Ken-Ichi Miyoshi, Tomomitsu Matono, Kenji Ohyama, Keiko Hosho, Hajime Isomoto
We conducted a multicenter retrospective study for evaluating the background of and diagnostic opportunity for 651 patients with primary hepatocellular carcinoma (HCC). The etiologies were hepatitis B virus (HBV) in 20.0% of patients, hepatitis C virus (HCV) in 36.3%, and non-B non-C (NBNC) in 43.5%. The characteristics of non-alcoholic NBNC HCC patients included low frequency of liver cirrhosis and high frequency of life style-related diseases. The mean diameter of HCC was approximately 4cm. Most patients were diagnosed using ultrasonography and dynamic computed tomography (CT)...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
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