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Oncology animal imaging

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https://www.readbyqxmd.com/read/27867722/feasibility-of-spatial-frequency-domain-imaging-sfdi-for-optically-characterizing-a-preclinical-oncology-model
#1
Syeda Tabassum, Yanyu Zhao, Raeef Istfan, Junjie Wu, David J Waxman, Darren Roblyer
Determination of chemotherapy efficacy early during treatment would provide more opportunities for physicians to alter and adapt treatment plans. Diffuse optical technologies may be ideally suited to track early biological events following chemotherapy administration due to low cost and high information content. We evaluated the use of spatial frequency domain imaging (SFDI) to characterize a small animal tumor model in order to move towards the goal of endogenous optical monitoring of cancer therapy in a controlled preclinical setting...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27858704/comparison-of-bipolar-radiofrequency-ablation-zones-in-an-in-vivo-porcine-model-correlation-of-histology-and-gross-pathological-findings
#2
Ole Gemeinhardt, Franz G M Poch, Bernhard Hiebl, Urte Kunz-Zurbuchen, Giuliano M Corte, Stefan F Thieme, Janis L Vahldiek, Stefan M Niehues, Martin E Kreis, Robert Klopfleisch, Kai S Lehmann
BACKGROUND: Continuing research ex vivo and in vivo with animal models is performed to advance the oncological safety of radiofrequency ablation (RFA) of liver tumors. In these experiments, frequently imaging modalities (e.g. MRI or CT) or macro-morphological measurements are used to determine the full extent of the different ablation zones inside of RFA lesions. However, no systematic study has been performed so far, which verified the accuracy of the macro-morphological findings. Therefore, the present study aimed to correlate histological and gross pathological findings of bipolar radiofrequency ablation zones of pig livers with regard to cell viability in vivo...
November 18, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27858408/preclinical-imaging-in-oncology-advances-and-perspectives
#3
Francesca Iommelli, Viviana DE Rosa, Cristina Terlizzi, Silvana Del Vecchio
Preclinical imaging with radiolabeled probes became an integral part of the complex translational process that moves a newly developed compound from laboratory to clinical application. Imaging studies in animal tumor models may be undertaken to test a newly synthesized tracer, a newly developed drug or to interrogate, in the living organism, specific molecular and biological processes underlying tumor growth and progression. The present review will try to delineate the current status and future perspectives of preclinical imaging in oncology by providing examples from recent literature...
November 18, 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27858404/advances-in-multimodal-molecular-imaging
#4
Luigi Auletta, Matteo Gramanzini, Gargiulo Sara, Sandra Albanese, Marco Salvatore, Adelaide Greco
INTRODUCTION: Preclinical molecular imaging is an emerging field. Improving the ability of scientists to study the molecular basis of human pathology in animals is of the utmost importance for future advances in all fields of human medicine. Moreover, the possibility of developing new imaging techniques or of implementing old ones adapted to the clinic is a significant area. EVIDENCE ACQUISITION: Cardiology, neurology, immunology and oncology have all been studied with preclinical molecular imaging...
November 18, 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27745815/reproducibility-of-parenchymal-blood-volume-measurements-using-an-angiographic-c-arm-ct-system
#5
Kerstin Mueller, Rebecca Fahrig, Michael Manhart, Yu Deuerling-Zheng, Jarrett Rosenberg, Teri Moore, Arundhuti Ganguly, Nishita Kothary
RATIONALE AND OBJECTIVES: Intra-procedural measurement of hepatic perfusion following liver embolization continues to be a challenge. Blood volume imaging before and after interventional procedures would allow identifying the treatment end point or even allow predicting treatment outcome. Recent liver oncology studies showed the feasibility of parenchymal blood volume (PBV) imaging using an angiographic C-arm system. This study was done to evaluate the reproducibility of PBV measurements using cone beam computed tomography (CBCT) before and after embolization of the liver in a swine model...
October 10, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27698938/optical-imaging-of-mesenchymal-epithelial-transition-factor-met-for-enhanced-detection-and-characterization-of-primary-and-metastatic-hepatic-tumors
#6
Shadi A Esfahani, Pedram Heidari, Sun A Kim, Shuji Ogino, Umar Mahmood
Purpose: To assess optical imaging of Mesenchymal-Epithelial Transition factor (MET) for delineation and characterization of intrahepatic models of human hepatocellular carcinoma (HCC) and metastatic colorectal cancer (CRC), and thereby demonstrate its potential use in precision oncology. Materials and Methods: MET expression in human CRC and HCC was assessed in tissue microarrays. We used GE-137, a modified cyanine 5-tagged peptide for MET targeting. HepG2 and Huh-7 (HCC) and HT-29 (CRC) cells with MET overexpression, and LNCaP cells (negative control) with minimal MET expression were incubated with the probe...
2016: Theranostics
https://www.readbyqxmd.com/read/27612010/tumour-and-normal-tissue-radiobiology-in-mouse-models-how-close-are-mice-to-mini-humans
#7
Bridget F Koontz, Frank Verhaegen, Dirk De Ruysscher
Animal modelling is essential to the study of radiobiology and the advancement of clinical radiation oncology by providing preclinical data. Mouse models in particular, have been highly utilized in the study of both tumour and normal tissue radiobiology because of their cost effectiveness and versatility. Technology has significantly advanced in preclinical radiation techniques to allow highly conformal image guided irradiation of small animals in an effort to mimic human treatment capabilities. However, the biological and physical limitations of animal modelling should be recognized and considered when interpreting preclinical radiotherapy studies...
September 9, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27609789/68ga-177lu-neobomb1-a-novel-radiolabeled-grpr-antagonist-for-theranostic-use-in-oncology
#8
Simone U Dalm, Ingrid L Bakker, Erik de Blois, Gabriela N Doeswijk, Mark W Konijnenberg, Francesca Orlandi, Donato Barbato, Mattia Tedesco, Theodosia Maina, Berthold A Nock, Marion de Jong
INTRODUCTION: Since overexpression of the gastrin releasing peptide receptor (GRPR) has been reported on various cancer types, e.g. prostate cancer and breast cancer, targeting this receptor with radioligands might have significant impact on staging and treatment of GRPR-expressing tumors. NeoBOMB1 is a novel DOTA-coupled GRPR antagonist with high affinity for GRPR and excellent in vivo stability. The purpose of this preclinical study was to further explore the use of NeoBOMB1 for theranostic application by determining the biodistribution of (68)Ga-NeoBOMB1 and (177)Lu-NeoBOMB1...
September 8, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27566102/high-resolution-multispectral-optoacoustic-tomography-of-the-vascularization-and-constitutive-hypoxemia-of-cancerous-tumors
#9
Andrei Chekkoury, Antonio Nunes, Jerome Gateau, Panagiotis Symvoulidis, Annette Feuchtinger, Nicolas Beziere, Saak V Ovsepian, Axel Walch, Vasilis Ntziachristos
Diversity of the design and alignment of illumination and ultrasonic transducers empower the fine scalability and versatility of optoacoustic imaging. In this study, we implement an innovative high-resolution optoacoustic mesoscopy for imaging the vasculature and tissue oxygenation within subcutaneous and orthotopic cancerous implants of mice in vivo through acquisition of tomographic projections over 180° at a central frequency of 24 MHz. High-resolution volumetric imaging was combined with multispectral functional measurements to resolve the exquisite inner structure and vascularization of the entire tumor mass using endogenous and exogenous optoacoustic contrast...
August 2016: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/27542255/radiofrequency-hyperthermia-promotes-the-therapeutic-effects-on-chemotherapeutic-resistant-breast-cancer-when-combined-with-heat-shock-protein-promoter-controlled-hsv-tk-gene-therapy-toward-imaging-guided-interventional-gene-therapy
#10
Jingfeng Luo, Xiaotian Wu, Fei Zhou, Yurong Zhou, Tongchun Huang, Fei Liu, Guocan Han, Luming Chen, Weixian Bai, Xia Wu, Jihong Sun, Xiaoming Yang
OBJECTIVE: Gene therapy is a frontier in modern medicine. In the present study, we explored a new technique for the effective treatment of multidrug-resistant (MDR) breast cancer by combining fully the advantages of multidisciplinary fields, including image-guided minimally invasive interventional oncology, radiofrequency technology, and direct intratumoral gene therapy. RESULTS: Combination treatment with PHSP-TK plus RFH resulted in significantly higher TK gene transfection/expression, as well as a lower cell proliferation rate and a higher cell apoptosis index, than those of control groups...
August 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27374079/chamaejasmenin-b-a-novel-candidate-inhibits-breast-tumor-metastasis-by-rebalancing-tgf-beta-paradox
#11
Qi Li, Yajie Wang, Hongbin Xiao, Yujie Li, Xiaoxi Kan, Xiaomin Wang, Ganlin Zhang, Zhixin Wang, Qing Yang, Xi Chen, Xiaogang Weng, Ying Chen, Bingbing Zhou, Yan Guo, Xucen Liu, Xiaoxin Zhu
Metastasis is the leading lethal factor severely restraining the effectiveness of clinical treatment. TGF-beta is the key regulator for metastasis and influences paradoxically on cancer progression. The known TGF-beta blockers exert little selectivity on its functions, indiscriminately causing the anti-metastatic and pro-growth effects. Under such circumstances, specifically rebalancing the oncological function of TGF-beta provides a crucial oncotarget against metastasis. In our study, we established the screening platform targeting cell motility and identified a potential flavonoid, Chamaejasmenin B (ICJ), extracted from Stellera chamaejasme L...
June 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27324368/evaluation-of-18-f-fluorothymidine-as-a-biomarker-for-early-therapy-response-in-a-mouse-model-of-colorectal-cancer
#12
Sara Rapic, Christel Vangestel, Jeroen Verhaeghe, David Thomae, Patrick Pauwels, Tim Van den Wyngaert, Steven Staelens, Sigrid Stroobants
PURPOSE: In oncology, positron emission tomography imaging using dedicated tracers as biomarkers may assist in early evaluation of therapy efficacy. Using 3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT), we investigated the early effects of chemotherapeutic treatment on cancer cell proliferation in a BRAF-mutated colorectal cancer xenograft model. PROCEDURES: Colo205 subcutaneously inoculated animals underwent 90-min dynamic imaging before and 24 h after treatment with vehicle (control), cetuximab (resistant) or irinotecan (sensitive)...
June 20, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27309986/effects-of-fasting-on-serial-measurements-of-hyperpolarized-1-13-c-pyruvate-metabolism-in-tumors
#13
Eva M Serrao, Tiago B Rodrigues, Ferdia A Gallagher, Mikko I Kettunen, Brett W C Kennedy, Sarah L Vowler, Keith A Burling, Kevin M Brindle
Imaging of the metabolism of hyperpolarized [1-(13) C]pyruvate has shown considerable promise in preclinical studies in oncology, particularly for the assessment of early treatment response. The repeatability of measurements of (13) C label exchange between pyruvate and lactate was determined in a murine lymphoma model in fasted and non-fasted animals. The fasted state showed lower intra-individual variability, although the [1-(13) C]lactate/[1-(13) C]pyruvate signal ratio was significantly greater in fasted than in non-fasted mice, which may be explained by the higher tumor lactate concentrations in fasted animals...
August 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27283417/fluorescence-lifetime-imaging-of-cancer-in-vivo
#14
Owen Peng, Walter J Akers
Optical imaging of fluorescent reporters in animal models of cancer has become a common tool in oncologic research. Fluorescent reporters including fluorescent proteins, organic dyes, and inorganic photonic materials are used in fluorescence spectroscopy, microscopy, and whole body preclinical imaging. Fluorescence lifetime imaging provides additional, quantitative information beyond that of conventional fluorescence intensity signals, enabling signal multiplexing, background separation, and biological sensing unique to fluorescent materials...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27234445/synthesis-and-in-vivo-imaging-of-n-3-11-c-methoxybenzyl-2-3-methoxyphenyl-ethylaniline-as-a-potential-targeting-agent-for-p-glycoprotein
#15
Debora Petroni, Antonietta Bartoli, Simona Rapposelli, Maria Digiacomo, Silvia Burchielli, Giulia Nesi, Annalina Lapucci, Silvia Pardini, Sabrina Fucci, Marco Macchia, Piero A Salvadori, Luca Menichetti
PURPOSE: The plasma membrane P-glycoprotein (Pgp) is an efflux transporter involved in multidrug resistance and in the onset of neurodegenerative disease. Its function and most mechanisms of action are still under investigation. We developed a C-11-labeled 2-arylethylphenylamine-([(11)C]AEPH) derivative for positron emission tomography (PET), as a novel probe to better understand the activity and the function of Pgp in vivo. PROCEDURES: The synthetic procedure and the quality control of the selected lead compound, [(11)C]AEPH-1, were set up and optimized...
May 27, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27145373/optical-imaging-probes-in-oncology
#16
Cristina Martelli, Alessia Lo Dico, Cecilia Diceglie, Giovanni Lucignani, Luisa Ottobrini
Cancer is a complex disease, characterized by alteration of different physiological molecular processes and cellular features. Keeping this in mind, the possibility of early identification and detection of specific tumor biomarkers by non-invasive approaches could improve early diagnosis and patient management.Different molecular imaging procedures provide powerful tools for detection and non-invasive characterization of oncological lesions. Clinical studies are mainly based on the use of computed tomography, nuclear-based imaging techniques and magnetic resonance imaging...
April 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27067794/fluorescence-and-cerenkov-luminescence-imaging-applications-in-small-animal-research
#17
J Schwenck, K Fuchs, S H L Eilenberger, A-M Rolle, S Castaneda Vega, W M Thaiss, F C Maier
This review addresses small animal optical imaging (OI) applications in diverse fields of basic research. In the past, OI has proven to be cost- and time-effective, allows real-time imaging as well as high-throughput analysis and does not imply the usage of ionizing radiation (with the exception of Cerenkov imaging applications). Therefore, this technique is widely spread - not only geographically, but also among very different fields of basic research - and is represented by a large body of publications. Originally used in oncology research, OI is nowadays emerging in further areas like inflammation and infectious disease as well as neurology...
2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27008208/precise-image-guided-irradiation-of-small-animals-a-flexible-non-profit-platform
#18
Falk Tillner, Prasad Thute, Steffen Löck, Antje Dietrich, Andriy Fursov, Robert Haase, Mathias Lukas, Bernd Rimarzig, Manfred Sobiella, Mechthild Krause, Michael Baumann, Rebecca Bütof, Wolfgang Enghardt
Preclinical in vivo studies using small animals are essential to develop new therapeutic options in radiation oncology. Of particular interest are orthotopic tumour models, which better reflect the clinical situation in terms of growth patterns and microenvironmental parameters of the tumour as well as the interplay of tumours with the surrounding normal tissues. Such orthotopic models increase the technical demands and the complexity of preclinical studies as local irradiation with therapeutically relevant doses requires image-guided target localisation and accurate beam application...
April 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/26975402/mechanistic-interrogation-of-combination-bevacizumab-dual-pi3k-mtor-inhibitor-response-in-glioblastoma-implementing-novel-mr-and-pet-imaging-biomarkers
#19
Philip J O'Halloran, Thomas Viel, David W Murray, Lydia Wachsmuth, Katrin Schwegmann, Stefan Wagner, Klaus Kopka, Monika A Jarzabek, Patrick Dicker, Sven Hermann, Cornelius Faber, Tim Klasen, Michael Schäfers, David O'Brien, Jochen H M Prehn, Andreas H Jacobs, Annette T Byrne
PURPOSE: Resistance to bevacizumab (BEV) in glioblastoma is believed to occur via activation of molecular networks including the mTOR/PI3K pathway. Using an MR/PET molecular imaging biomarker approach, we investigated the response to combining BEV with the mTOR/PI3K inhibitor BEZ235. METHODS: Tumours were established by orthotopically implanting U87MG-luc2 cells in mice. Animals were treated with BEZ235 and/or BEV, and imaged using diffusion-weighted-MRI, T2-weighted and T2*-weighted before and after administration of superparamagnetic iron oxide contrast agent...
August 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/26792490/advanced-small-animal-conformal-radiation-therapy-device
#20
Sunil Sharma, Ganesh Narayanasamy, Beata Przybyla, Jessica Webber, Marjan Boerma, Richard Clarkson, Eduardo G Moros, Peter M Corry, Robert J Griffin
We have developed a small animal conformal radiation therapy device that provides a degree of geometrical/anatomical targeting comparable to what is achievable in a commercial animal irradiator. small animal conformal radiation therapy device is capable of producing precise and accurate conformal delivery of radiation to target as well as for imaging small animals. The small animal conformal radiation therapy device uses an X-ray tube, a robotic animal position system, and a digital imager. The system is in a steel enclosure with adequate lead shielding following National Council on Radiation Protection and Measurements 49 guidelines and verified with Geiger-Mueller survey meter...
January 20, 2016: Technology in Cancer Research & Treatment
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