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Oncology animal imaging

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https://www.readbyqxmd.com/read/28053523/anti-muc1-nano-aptamers-for-triple-negative-breast-cancer-imaging-by-single-photon-emission-computed-tomography-in-inducted-animals-initial-considerations
#1
Fagner Santos do Carmo, Eduardo Ricci-Junior, Cristal Cerqueira-Coutinho, Marta de Souza Albernaz, Emerson Soares Bernardes, Sotiris Missailidis, Ralph Santos-Oliveira
The early and specific detection of tumors remains a barrier in oncology, especially in cases such as the triple-negative breast cancer (TNBC). To address this gap, aptamers have found an important application in the recognition of tumor biomarkers such as mucin 1 (MUC1). However, there are still some difficulties in the use of aptamer, as their rapid biological clearance makes their use as drugs limited. In this study, the anti-MUC1 aptamer was used as a drug delivery system (DDS) for a radioactive polymeric nanoparticle (NP) in the imaging of TNBCs...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28050749/evaluation-of-18-f-cp18-as-a-substrate-based-apoptosis-imaging-agent-for-the-assessment-of-early-treatment-response-in-oncology
#2
Sara Rapic, Christel Vangestel, Filipe Elvas, Jeroen Verhaeghe, Tim Van den Wyngaert, Leonie Wyffels, Patrick Pauwels, Steven Staelens, Sigrid Stroobants
PURPOSE: The substrate-based positron emission tomography (PET) tracer [(18)F]CP18 is capable of detecting the activity of caspase-3/7, two key executioner proteases in the apoptosis pathway, through selective cleavage of the ligand by the activated proteases and subsequent accumulation in apoptotic cells. Using an in vitro and in vivo model of colorectal cancer (CRC), we investigated whether [(18)F]CP18 tracer accumulation provides a measure for apoptosis and reliably reflects early treatment response to chemotherapeutics...
January 3, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28046380/we-fg-202-06-the-use-of-hybrid-pet-mri-for-identifying-the-presence-of-cardiac-inflammation-following-external-beam-irradiation
#3
O El-Sherif, I Xhaferllari, J Sykes, J Butler, J Battista, G Wisenberg, F Prato, S Gaede
PURPOSE: To monitor the evolution of radiation-induced cardiac inflammation in a canine model using hybrid positron emission tomography (PET/magnetic resonance imaging (MRI). METHODS: Research ethics approval was obtained for a longitudinal imaging study of 5 canines after cardiac irradiation. Animals were imaged at baseline, 3 months, 6 months, and 12 months post cardiac irradiation using a hybrid PET-MRI system (Biograph mMR, Siemens Healthcare). The imaging protocol was designed to assess changes in cardiac inflammation using (18) F-fluorodeoxyglucose ((18) F-FDG) PET tracer...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28040598/radiolabeled-bombesin-derivatives-for-preclinical-oncological-imaging
#4
REVIEW
Carolina de Aguiar Ferreira, Leonardo Lima Fuscaldi, Danyelle M Townsend, Domenico Rubello, André Luís Branco de Barros
Despite efforts, cancer is still one of the leading causes of morbidity and mortality worldwide, with approximately 14 million new cases and 8.2 million cancer-related deaths each year, according to the World Health Organization. Among the strategies to reduce cancer progression and improving its management, implementing early detection technologies is crucial. Based on the fact that several types of cancer cells overexpress surface receptors, small molecule ligands, such as peptides, have been developed to allow tumor identification at earlier stages...
December 29, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27867722/feasibility-of-spatial-frequency-domain-imaging-sfdi-for-optically-characterizing-a-preclinical-oncology-model
#5
Syeda Tabassum, Yanyu Zhao, Raeef Istfan, Junjie Wu, David J Waxman, Darren Roblyer
Determination of chemotherapy efficacy early during treatment would provide more opportunities for physicians to alter and adapt treatment plans. Diffuse optical technologies may be ideally suited to track early biological events following chemotherapy administration due to low cost and high information content. We evaluated the use of spatial frequency domain imaging (SFDI) to characterize a small animal tumor model in order to move towards the goal of endogenous optical monitoring of cancer therapy in a controlled preclinical setting...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27858704/comparison-of-bipolar-radiofrequency-ablation-zones-in-an-in-vivo-porcine-model-correlation-of-histology-and-gross-pathological-findings
#6
Ole Gemeinhardt, Franz G M Poch, Bernhard Hiebl, Urte Kunz-Zurbuchen, Giuliano M Corte, Stefan F Thieme, Janis L Vahldiek, Stefan M Niehues, Martin E Kreis, Robert Klopfleisch, Kai S Lehmann
BACKGROUND: Continuing research ex vivo and in vivo with animal models is performed to advance the oncological safety of radiofrequency ablation (RFA) of liver tumors. In these experiments, frequently imaging modalities (e.g. MRI or CT) or macro-morphological measurements are used to determine the full extent of the different ablation zones inside of RFA lesions. However, no systematic study has been performed so far, which verified the accuracy of the macro-morphological findings. Therefore, the present study aimed to correlate histological and gross pathological findings of bipolar radiofrequency ablation zones of pig livers with regard to cell viability in vivo...
November 18, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27858408/preclinical-imaging-in-oncology-advances-and-perspectives
#7
Francesca Iommelli, Viviana DE Rosa, Cristina Terlizzi, Silvana Del Vecchio
Preclinical imaging with radiolabeled probes became an integral part of the complex translational process that moves a newly developed compound from laboratory to clinical application. Imaging studies in animal tumor models may be undertaken to test a newly synthesized tracer, a newly developed drug or to interrogate, in the living organism, specific molecular and biological processes underlying tumor growth and progression. The aim of the present review is to outline the current knowledge and future perspectives of preclinical imaging in oncology by providing examples from recent literature...
March 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27858404/advances-in-multimodal-molecular-imaging
#8
Luigi Auletta, Matteo Gramanzini, Sara Gargiulo, Sandra Albanese, Marco Salvatore, Adelaide Greco
Preclinical molecular imaging is an emerging field. Improving the ability of scientists to study the molecular basis of human pathology in animals is of the utmost importance for future advances in all fields of human medicine. Moreover, the possibility of developing new imaging techniques or of implementing old ones adapted to the clinic is a significant area. Cardiology, neurology, immunology and oncology have all been studied with preclinical molecular imaging. The functional techniques of photoacoustic imaging (PAI), fluorescence molecular tomography (FMT), positron emission tomography (PET), and single photon emission computed tomography (SPECT) in association with each other or with the anatomic reference provided by computed tomography (CT) as well as with anatomic and functional information provided by magnetic resonance (MR) have all been proficiently applied to animal models of human disease...
March 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27745815/reproducibility-of-parenchymal-blood-volume-measurements-using-an-angiographic-c-arm-ct-system
#9
Kerstin Mueller, Rebecca Fahrig, Michael Manhart, Yu Deuerling-Zheng, Jarrett Rosenberg, Teri Moore, Arundhuti Ganguly, Nishita Kothary
RATIONALE AND OBJECTIVES: Intra-procedural measurement of hepatic perfusion following liver embolization continues to be a challenge. Blood volume imaging before and after interventional procedures would allow identifying the treatment end point or even allow predicting treatment outcome. Recent liver oncology studies showed the feasibility of parenchymal blood volume (PBV) imaging using an angiographic C-arm system. This study was done to evaluate the reproducibility of PBV measurements using cone beam computed tomography (CBCT) before and after embolization of the liver in a swine model...
October 10, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27698938/optical-imaging-of-mesenchymal-epithelial-transition-factor-met-for-enhanced-detection-and-characterization-of-primary-and-metastatic-hepatic-tumors
#10
Shadi A Esfahani, Pedram Heidari, Sun A Kim, Shuji Ogino, Umar Mahmood
Purpose: To assess optical imaging of Mesenchymal-Epithelial Transition factor (MET) for delineation and characterization of intrahepatic models of human hepatocellular carcinoma (HCC) and metastatic colorectal cancer (CRC), and thereby demonstrate its potential use in precision oncology. Materials and Methods: MET expression in human CRC and HCC was assessed in tissue microarrays. We used GE-137, a modified cyanine 5-tagged peptide for MET targeting. HepG2 and Huh-7 (HCC) and HT-29 (CRC) cells with MET overexpression, and LNCaP cells (negative control) with minimal MET expression were incubated with the probe...
2016: Theranostics
https://www.readbyqxmd.com/read/27612010/tumour-and-normal-tissue-radiobiology-in-mouse-models-how-close-are-mice-to-mini-humans
#11
Bridget F Koontz, Frank Verhaegen, Dirk De Ruysscher
Animal modelling is essential to the study of radiobiology and the advancement of clinical radiation oncology by providing preclinical data. Mouse models in particular have been highly utilized in the study of both tumour and normal tissue radiobiology because of their cost effectiveness and versatility. Technology has significantly advanced in preclinical radiation techniques to allow highly conformal image-guided irradiation of small animals in an effort to mimic human treatment capabilities. However, the biological and physical limitations of animal modelling should be recognized and considered when interpreting preclinical radiotherapy (RT) studies...
January 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/27609789/68ga-177lu-neobomb1-a-novel-radiolabeled-grpr-antagonist-for-theranostic-use-in-oncology
#12
Simone U Dalm, Ingrid L Bakker, Erik de Blois, Gabriela N Doeswijk, Mark W Konijnenberg, Francesca Orlandi, Donato Barbato, Mattia Tedesco, Theodosia Maina, Berthold A Nock, Marion de Jong
INTRODUCTION: Since overexpression of the gastrin releasing peptide receptor (GRPR) has been reported on various cancer types, e.g. prostate cancer and breast cancer, targeting this receptor with radioligands might have significant impact on staging and treatment of GRPR-expressing tumors. NeoBOMB1 is a novel DOTA-coupled GRPR antagonist with high affinity for GRPR and excellent in vivo stability. The purpose of this preclinical study was to further explore the use of NeoBOMB1 for theranostic application by determining the biodistribution of (68)Ga-NeoBOMB1 and (177)Lu-NeoBOMB1...
September 8, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27566102/high-resolution-multispectral-optoacoustic-tomography-of-the-vascularization-and-constitutive-hypoxemia-of-cancerous-tumors
#13
Andrei Chekkoury, Antonio Nunes, Jerome Gateau, Panagiotis Symvoulidis, Annette Feuchtinger, Nicolas Beziere, Saak V Ovsepian, Axel Walch, Vasilis Ntziachristos
Diversity of the design and alignment of illumination and ultrasonic transducers empower the fine scalability and versatility of optoacoustic imaging. In this study, we implement an innovative high-resolution optoacoustic mesoscopy for imaging the vasculature and tissue oxygenation within subcutaneous and orthotopic cancerous implants of mice in vivo through acquisition of tomographic projections over 180° at a central frequency of 24 MHz. High-resolution volumetric imaging was combined with multispectral functional measurements to resolve the exquisite inner structure and vascularization of the entire tumor mass using endogenous and exogenous optoacoustic contrast...
August 2016: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/27542255/radiofrequency-hyperthermia-promotes-the-therapeutic-effects-on-chemotherapeutic-resistant-breast-cancer-when-combined-with-heat-shock-protein-promoter-controlled-hsv-tk-gene-therapy-toward-imaging-guided-interventional-gene-therapy
#14
Jingfeng Luo, Xiaotian Wu, Fei Zhou, Yurong Zhou, Tongchun Huang, Fei Liu, Guocan Han, Luming Chen, Weixian Bai, Xia Wu, Jihong Sun, Xiaoming Yang
OBJECTIVE: Gene therapy is a frontier in modern medicine. In the present study, we explored a new technique for the effective treatment of multidrug-resistant (MDR) breast cancer by combining fully the advantages of multidisciplinary fields, including image-guided minimally invasive interventional oncology, radiofrequency technology, and direct intratumoral gene therapy. RESULTS: Combination treatment with PHSP-TK plus RFH resulted in significantly higher TK gene transfection/expression, as well as a lower cell proliferation rate and a higher cell apoptosis index, than those of control groups...
October 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27374079/chamaejasmenin-b-a-novel-candidate-inhibits-breast-tumor-metastasis-by-rebalancing-tgf-beta-paradox
#15
Qi Li, Yajie Wang, Hongbin Xiao, Yujie Li, Xiaoxi Kan, Xiaomin Wang, Ganlin Zhang, Zhixin Wang, Qing Yang, Xi Chen, Xiaogang Weng, Ying Chen, Bingbing Zhou, Yan Guo, Xucen Liu, Xiaoxin Zhu
Metastasis is the leading lethal factor severely restraining the effectiveness of clinical treatment. TGF-beta is the key regulator for metastasis and influences paradoxically on cancer progression. The known TGF-beta blockers exert little selectivity on its functions, indiscriminately causing the anti-metastatic and pro-growth effects. Under such circumstances, specifically rebalancing the oncological function of TGF-beta provides a crucial oncotarget against metastasis. In our study, we established the screening platform targeting cell motility and identified a potential flavonoid, Chamaejasmenin B (ICJ), extracted from Stellera chamaejasme L...
June 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27324368/evaluation-of-18-f-fluorothymidine-as-a-biomarker-for-early-therapy-response-in-a-mouse-model-of-colorectal-cancer
#16
Sara Rapic, Christel Vangestel, Jeroen Verhaeghe, David Thomae, Patrick Pauwels, Tim Van den Wyngaert, Steven Staelens, Sigrid Stroobants
PURPOSE: In oncology, positron emission tomography imaging using dedicated tracers as biomarkers may assist in early evaluation of therapy efficacy. Using 3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT), we investigated the early effects of chemotherapeutic treatment on cancer cell proliferation in a BRAF-mutated colorectal cancer xenograft model. PROCEDURES: Colo205 subcutaneously inoculated animals underwent 90-min dynamic imaging before and 24 h after treatment with vehicle (control), cetuximab (resistant) or irinotecan (sensitive)...
February 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27309986/effects-of-fasting-on-serial-measurements-of-hyperpolarized-1-13-c-pyruvate-metabolism-in-tumors
#17
Eva M Serrao, Tiago B Rodrigues, Ferdia A Gallagher, Mikko I Kettunen, Brett W C Kennedy, Sarah L Vowler, Keith A Burling, Kevin M Brindle
Imaging of the metabolism of hyperpolarized [1-(13) C]pyruvate has shown considerable promise in preclinical studies in oncology, particularly for the assessment of early treatment response. The repeatability of measurements of (13) C label exchange between pyruvate and lactate was determined in a murine lymphoma model in fasted and non-fasted animals. The fasted state showed lower intra-individual variability, although the [1-(13) C]lactate/[1-(13) C]pyruvate signal ratio was significantly greater in fasted than in non-fasted mice, which may be explained by the higher tumor lactate concentrations in fasted animals...
August 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27283417/fluorescence-lifetime-imaging-of-cancer-in-vivo
#18
Owen Peng, Walter J Akers
Optical imaging of fluorescent reporters in animal models of cancer has become a common tool in oncologic research. Fluorescent reporters including fluorescent proteins, organic dyes, and inorganic photonic materials are used in fluorescence spectroscopy, microscopy, and whole body preclinical imaging. Fluorescence lifetime imaging provides additional, quantitative information beyond that of conventional fluorescence intensity signals, enabling signal multiplexing, background separation, and biological sensing unique to fluorescent materials...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27234445/synthesis-and-in-vivo-imaging-of-n-3-11-c-methoxybenzyl-2-3-methoxyphenyl-ethylaniline-as-a-potential-targeting-agent-for-p-glycoprotein
#19
Debora Petroni, Antonietta Bartoli, Simona Rapposelli, Maria Digiacomo, Silvia Burchielli, Giulia Nesi, Annalina Lapucci, Silvia Pardini, Sabrina Fucci, Marco Macchia, Piero A Salvadori, Luca Menichetti
PURPOSE: The plasma membrane P-glycoprotein (Pgp) is an efflux transporter involved in multidrug resistance and in the onset of neurodegenerative disease. Its function and most mechanisms of action are still under investigation. We developed a C-11-labeled 2-arylethylphenylamine-([(11)C]AEPH) derivative for positron emission tomography (PET), as a novel probe to better understand the activity and the function of Pgp in vivo. PROCEDURES: The synthetic procedure and the quality control of the selected lead compound, [(11)C]AEPH-1, were set up and optimized...
May 27, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27145373/optical-imaging-probes-in-oncology
#20
Cristina Martelli, Alessia Lo Dico, Cecilia Diceglie, Giovanni Lucignani, Luisa Ottobrini
Cancer is a complex disease, characterized by alteration of different physiological molecular processes and cellular features. Keeping this in mind, the possibility of early identification and detection of specific tumor biomarkers by non-invasive approaches could improve early diagnosis and patient management.Different molecular imaging procedures provide powerful tools for detection and non-invasive characterization of oncological lesions. Clinical studies are mainly based on the use of computed tomography, nuclear-based imaging techniques and magnetic resonance imaging...
April 27, 2016: Oncotarget
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