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milk and cancer

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https://www.readbyqxmd.com/read/28714565/mri-compatible-breast-rib-phantom-for-evaluating-ultrasonic-thermal-exposures
#1
Georgios Menikou, Marinos Yiannakou, Christos Yiallouras, Cleanthis Ioannides, Christakis Damianou
INTRODUCTION: The target of this study was the development of a magnetic resonance imaging (MRI) compatible breast phantom for focused ultrasound which includes plastic (ABS) ribs. The objective of the current study was the evaluation of a focused ultrasound procedure using the proposed phantom that eliminates rib heating. MATERIAL AND METHODS: The proposed phantom was evaluated using two different focused ultrasound exposures. The surrounding breast tissue was mimicked using an agar-silica-evaporation milk gel (2% w/v - 2% w/v - 40% v/v)...
July 17, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28688542/evaluation-of-apoptotic-activity-of-withania-coagulans-methanolic-extract-against-human-breast-cancer-and-vero-cell-lines
#2
Rumana Ahmad, Afreen Fatima, A N Srivastava, Mohsin Ali Khan
BACKGROUND: The genus Withania (Family: Solanaceae) holds an important position in Ayurveda, the Indian traditional system of medicine. Withania somnifera Dunal and Withania coagulans Dunal have been documented in folklore as panaceas for various ailments since time immemorial. W. coagulans (WC), commonly called as Indian cheese maker is used for fermenting milk for cheese production in various parts of India. OBJECTIVES: In the study, in vitro cytotoxicity of methanolic extract of dried fruits (berries) of WC was evaluated in a dose dependent manner using trypan blue dye exclusion method against human breast cancer cell line MDA-MB-231 and normal kidney epithelial cell line Vero in the range 20-200 μg/ml...
July 6, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28686955/targeting-stat3-with-silibinin-to-improve-cancer-therapeutics
#3
REVIEW
Joaquim Bosch-Barrera, Bernardo Queralt, Javier A Menendez
Signal transducer and activator of transcription 3 (STAT3) has a prominent role in mediating resistance to conventional chemo-/radio-therapies and modern targeted drugs. While a number of STAT3 inhibitors have been shown to enhance the efficacy of therapeutic agents in vitro, the majority of them have yet to enter clinical evaluation mostly because of lack of efficacy issues. Silibinin is the main component of the silymarin complex, a standardized extract obtained from the seeds of the milk thistle herb Silybum marianum...
June 23, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28681026/a-seasonal-study-for-determination-of-aflatoxin-m1-level-in-dairy-products-in-iranshahr-iran
#4
N Sohrabi, H Gharahkoli
BACKGROUND AND PURPOSE: Aflatoxin M1, in milk and dairy products, is classified by the International Agency for Research on Cancer as human carcinogens (class 2B). The aim of this study was to evaluate aflatoxin M1 contamination level in dairy products from Iranshahr city, Iran, using ELISA technique. MATERIALS AND METHODS: In our study, 87 samples of milk, white cheese, yoghurt, and butter were collected in different seasons and after preparation, were analyzed by ELISA technique...
September 2016: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/28664715/the-history-of-arsenical-pesticides-and-health-risks-related-to-the-use-of-agent-blue
#5
Vladimir Bencko, Florence Yan Li Foong
Arsenicals in agriculture. Beginning in the 1970s, the use of arsenic compounds for such purposes as wood preservatives, began to grow. By 1980, in the USA, 70% of arsenic had been consumed for the production of wood preservatives. This practice was later stopped, due to the US Environmental Protection Agency (EPA) ban of the arsenic-and chromium-based wood preservative chromated copper arsenate. In the past, arsenical herbicides containing cacodylic acid as an active ingredient have been used extensively in the USA, from golf courses to cotton fields, and drying-out the plants before harvesting...
June 12, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28663148/oral-reproductive-and-developmental-toxicity-of-lignosus-rhinocerotis-mycelium-in-rat
#6
Bo-Yi Jhou, Hsiao-Hui Liu, Shu-Hsing Yeh, Chin-Chu Chen
ETHNOPHARMACOLOGICAL RELEVANCE: Lignosus rhinocerotis (L. rhinocerotis), also known as the tiger milk mushroom, is widely used as traditional medicine and as soup ingredient in Malaysia and Hong Kong. It is edible and is used traditionally for the treatment of fever, cough, asthma, wounds, chronic hepatitis, gastric ulcers and cancers. In view of its safety profile, little information is found in scientific literature. The objective of this study is to investigate developmental toxicity of L...
June 27, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28657208/silibinin-stimluates-apoptosis-by-inducing-generation-of-ros-and-er-stress-in-human-choriocarcinoma-cells
#7
Jiyeon Ham, Whasun Lim, Fuller W Bazer, Gwonhwa Song
Silibinin is a flavonolignan extracted from seeds of milk thistles. Traditionally, it has been used as a therapeutic agent for liver disorders, and now it is well-known for its anti-cancer effects. However, studies on anti-cancer effects of silibinin on choriocarcinoma are very limited. Therefore, we performed proliferation and apoptosis assays to determine effects of silibinin on the viability of human choriocarcinoma (JAR and JEG3) cells. Our results showed that silibinin significantly inhibited proliferation and induced apoptosis in both JAR and JEG3 cells, and significantly increased reactive oxygen species (ROS) and lipid peroxidation...
June 28, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28653875/mfg-e8-overexpression-promotes-colorectal-cancer-progression-via-akt-mmps-signalling
#8
Qiujie Zhao, Lin Xu, Xiaoyan Sun, Kai Zhang, Huimin Shen, Yanan Tian, Fengkai Sun, Yanqing Li
Several studies have revealed that MFG-E8 (milk fat globule-epidermal growth factor 8) is related to tumour development and progression. However, the relationship between MFG-E8 expression and metastasis in colorectal cancer patients and the role of MFG-E8 in colorectal cancer invasion and progression remain unknown. In this study, we performed immunohistochemistry and quantitative real-time polymerase chain reaction to assess MFG-E8 expression in colorectal cancer and adjacent non-cancerous tissues. Colorectal cancer RNAseq data from The Cancer Genome Atlas project were downloaded and MFG-E8 expression was analysed...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28649371/recent-advances-in-microbial-fermentation-for-dairy-and-health
#9
REVIEW
Daragh Hill, Ivan Sugrue, Elke Arendt, Colin Hill, Catherine Stanton, R Paul Ross
Microbial fermentation has been used historically for the preservation of foods, the health benefits of which have since come to light. Early dairy fermentations depended on the spontaneous activity of the indigenous microbiota of the milk. Modern fermentations rely on defined starter cultures with desirable characteristics to ensure consistency and commercial viability. The selection of defined starters depends on specific phenotypes that benefit the product by guaranteeing shelf life and ensuring safety, texture, and flavour...
2017: F1000Research
https://www.readbyqxmd.com/read/28643865/characterization-and-biological-function-of-milk-derived-mirnas
#10
Regina Golan-Gerstl, Yaffa Elbaum Shiff, Vardit Lavi-Moshayoff, Daniel Schecter Dena Leshkowitz, Shimon Reif
SCOPE: Breastfeeding is associated with reduced risk of infection, immune mediated disorders, obesity and even cancer. Recently it was found that breast milk contains a variety of microRNAs (miRNAs) in the skim and fat layer that can be transferred to infants, and appear to play important roles in those biological functions. METHODS AND RESULTS: This study applied Next Generation Sequencing and quantitative real time PCR analysis to determine the miRNA expression profile of the skim and fat fraction of human, goat, and bovine milk as well as infant formulas...
June 23, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28611768/innate-immunity-and-breast-milk
#11
REVIEW
Nicole Theresa Cacho, Robert M Lawrence
Human milk is a dynamic source of nutrients and bioactive factors; unique in providing for the human infant's optimal growth and development. The growing infant's immune system has a number of developmental immune deficiencies placing the infant at increased risk of infection. This review focuses on how human milk directly contributes to the infant's innate immunity. Remarkable new findings clarify the multifunctional nature of human milk bioactive components. New research techniques have expanded our understanding of the potential for human milk's effect on the infant that will never be possible with milk formulas...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28594102/the-inhibition-effects-of-some-natural-products-on-lactoperoxidase-purified-from-bovine-milk
#12
Zeynep Köksal, Ramazan Kalın, Serpil Gerni, İlhami Gülçin, Hasan Özdemir
In this study, inhibition profiles of some natural products, which are digoxin, L-Dopa, dopamine, isoliquiritigenin, and 1,1,2,2-tetrakis(p-hydroxyphenyl)ethane (Tetrakis), were investigated against bovine lactoperoxidase (LPO) enzyme. Digoxin, L-Dopa, and dopamine are active ingredients of some drugs, which have important functions in our body, especially in cases of heart failure. Isoliquiritigenin and tetrakis are types of natural phenolic compounds, which play an important role in cancer prevention and treatment...
June 8, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28589445/chemoprevention-of-breast-cancer-by-transdermal-delivery-of-%C3%AE-santalol-through-breast-skin-and-mammary-papilla-nipple
#13
Kaushalkumar Dave, Fahd M Alsharif, Saiful Islam, Chandradhar Dwivedi, Omathanu Perumal
PURPOSE: Almost all breast cancers originate from epithelial cells lining the milk ducts in the breast. To this end, the study investigated the feasibility of localized transdermal delivery of α-santalol, a natural chemopreventive agent to the breast. METHODS: Different α-santalol formulations (cream, solution and microemulsion) were developed and the in vitro permeability was studied using excised animal (porcine and rat) and human breast skin/mammary papilla (nipple)...
June 6, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28588430/gut-microbial-diversity-in-health-and-disease-experience-of-healthy-indian-subjects-and-colon-carcinoma-and-inflammatory-bowel-disease-patients
#14
V Deepak Bamola, Arnab Ghosh, Raj Kishor Kapardar, Banwari Lal, Simrita Cheema, Priyangshu Sarma, Rama Chaudhry
Background: The intestinal microbiota, through complex interactions with the gut mucosa, play a key role in the pathogenesis of colon carcinoma and inflammatory bowel disease (IBD). The disease condition and dietary habits both influence gut microbial diversity. Objective: The aim of this study was to assess the gut microbial profile of healthy subjects and patients with colon carcinoma and IBD. Healthy subjects included 'Indian vegetarians/lactovegetarians', who eat plant produce, milk and milk products, and 'Indian non-vegetarians', who eat plant produce, milk and milk products, certain meats and fish, and the eggs of certain birds and fish...
2017: Microbial Ecology in Health and Disease
https://www.readbyqxmd.com/read/28578968/physicochemical-characterization-and-antitumour-activity-of-exopolysaccharides-produced-by-lactobacillus-casei-sb27-from-yak-milk
#15
Wei Di, Lanwei Zhang, Shumei Wang, Huaxi Yi, Xue Han, Rongbo Fan, Yingchun Zhang
Two high molecular weight fractions (LW1 and LW2) of exopolysaccharides (EPSs) produced by Lactobacillus casei SB27 were isolated from yak milk obtained from the Gansu Tibetan area of China. GC-MS, FTIR spectroscopy, methylation analysis and FE-SEM analysis were performed to elucidate the physicochemical characterization of these two fractions, and their in vitro antitumour activities were also evaluated. The molecular weights (Mws) of LW1 and LW2 as determined by HPGPC were 25.10 and 12.34kDa, respectively...
September 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28488344/nipple-aspirate-fluid-a-liquid-biopsy-for-diagnosing-breast-health
#16
Sadr-Ul Shaheed, Catherine Tait, Kyriacos Kyriacou, Joanne Mullarkey, Wayne Burrill, Laurence H Patterson, Richard Linforth, Mohamed Salhab, Chris Sutton
PURPOSE: Nipple secretions are protein-rich and a potential source of breast cancer biomarkers for breast cancer screening. Previous studies of specific proteins have shown limited correlation with clinicopatholigical features. Our aim, in this pilot study, was to investigate the intra- and inter-patient protein composition of nipple secretions and the implications for their use as liquid biopsies. EXPERIMENTAL DESIGN: Matched pairs of NAF (n = 15) were characterised for physicochemical properties and SDS PAGE...
May 10, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28473429/atraumatic-chylous-ascites-an-unusual-presentation-of-bladder-cancer
#17
Ashish Srinivasan, Ross Apostolov, Amanda Leong, Douglas Johnson
We describe a case of bladder cancer presenting with atraumatic chylous ascites, which remains an extremely rare presentation of this condition. A previously well, elderly ex-smoker with no prior history of abdominal surgery was referred for investigation of progressive dyspnoea, increasing peripheral oedema and new-onset ascites, on a background of long-standing alcohol consumption (four standard drinks daily). Liver biochemistry and coagulation profile were normal apart from marked hypoalbuminaemia. Doppler ultrasound of the liver demonstrated normal echotexture and patent vasculature...
May 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28467661/circulating-insulin-like-growth-factor-related-biomarkers-correlates-and-responses-to-calcium-supplementation-in-colorectal-adenoma-patients
#18
Caroline Y Um, Veronika Fedirko, W Dana Flanders, Christine Höflich, Elisa Wirthgen, Roberd M Bostick
Circulating insulin-like growth factor 1 (IGF-1) may be directly associated with colorectal cancer risk, and IGF binding protein 3 (IGFBP-3) is one of the most abundantly expressed binding proteins in various cancers. Calcium intakes, primarily from food, have been directly associated with circulating IGF-1, but whether supplemental calcium affects IGF-1 and IGFBP-3 is unknown. We tested the effects of 1.0 and 2.0 g of supplemental elemental calcium daily on circulating IGF-1 and IGFBP-3 concentrations in colorectal adenoma patients in a randomized, double-blinded, placebo-controlled clinical trial (n = 193)...
May 3, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28466508/adverse-child-health-impacts-resulting-from-food-adulterations-in-the-greater-china-region
#19
REVIEW
W C Li, C F Chow
Food adulteration has a long history in human society, and it still occurs in modern times. Because children are relatively vulnerable to food adulterants, studying the health impacts of food adulteration on children is important. This article provides an overview of the child health impacts of food adulterants in two recent food adulteration incidents in the Greater China Region: 1) a plasticizer incident in Taiwan and 2) a 2,4,6-triamino-1,3,5-triazine (melamine)-tainted milk incident in China. The involved food adulterants (bis(2-ethylhexyl) phthalate [DEHP], diisononyl phthalate [DiNP] and melamine) are harmful to the hippocampus, kidneys, reproductive organs, and immune system of children, and they also increase the risk of cancer...
May 2, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28450523/isolation-of-two-virus-like-circular-dnas-from-commercially-available-milk-samples
#20
Konstantina Falida, Sebastian Eilebrecht, Karin Gunst, Harald Zur Hausen, Ethel-Michele de Villiers
Epidemiological data indicate a potential relationship between milk and dairy product consumption and the incidence of breast cancer, as well as neurodegenerative diseases. We report the isolation of two novel circular DNA molecules isolated from commercially available milk.
April 27, 2017: Genome Announcements
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