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https://www.readbyqxmd.com/read/27894063/loss-of-glutaredoxin-3-impedes-mammary-lobuloalveolar-development-during-pregnancy-and-lactation
#1
Khanh Pham, Jie Dong, Xiqian Jiang, Ying Qu, Han Yu, Yisheng Yang, Walter Olea, Juan C Marini, Lawrence Chan, Jin Wang, Xander H T Wehrens, Xiaojiang Cui, Yi Li, Darryl L Hadsell, Ninghui Cheng
Mammalian glutaredoxin 3 (Grx3) has been shown to be important for regulating cellular redox homeostasis in the cell. Our previous studies indicate that Grx3 is significantly overexpressed in various human cancers including breast cancer and demonstrate that Grx3 controls cancer cell growth and invasion by regulating ROS and NF-κB signaling pathways. However, it remains to be determined whether Grx3 is required for normal mammary gland development and how it contributes to epithelial cell proliferation and differentiation in vivo In the present study, we examined Grx3 expression in different cell types within the developing mouse mammary gland (MG) and found enhanced expression of Grx3 at pregnancy and lactation stages...
November 15, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27882862/milk-and-dairy-products-good-or-bad-for-human-health-an-assessment-of-the-totality-of-scientific-evidence
#2
REVIEW
Tanja Kongerslev Thorning, Anne Raben, Tine Tholstrup, Sabita S Soedamah-Muthu, Ian Givens, Arne Astrup
BACKGROUND: There is scepticism about health effects of dairy products in the public, which is reflected in an increasing intake of plant-based drinks, for example, from soy, rice, almond, or oat. OBJECTIVE: This review aimed to assess the scientific evidence mainly from meta-analyses of observational studies and randomised controlled trials, on dairy intake and risk of obesity, type 2 diabetes, cardiovascular disease, osteoporosis, cancer, and all-cause mortality...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27869663/dietary-protein-sources-and-incidence-of-breast-cancer-a-dose-response-meta-analysis-of-prospective-studies
#3
Jing Wu, Rong Zeng, Junpeng Huang, Xufeng Li, Jiren Zhang, James Chung-Man Ho, Yanfang Zheng
Protein is important to the human body, and different sources of protein may have different effects on the risk of breast cancer. Thus, we conducted a meta-analysis to investigate the association between different dietary protein sources and breast cancer risk. PubMed and several databases were searched until December 2015. Relevant articles were retrieved according to specific searching criteria. Forty-six prospective studies were included. The summary relative risk (RR) for highest versus lowest intake was 1...
November 17, 2016: Nutrients
https://www.readbyqxmd.com/read/27867187/crosstalk-of-ros-rns-and-autophagy-in-silibinin-induced-apoptosis-of-mcf-7-human-breast-cancer-cells-in-vitro
#4
Nan Zheng, Lu Liu, Wei-Wei Liu, Fei Li, Toshihiko Hayashi, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejima
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles in regulating cell survival and death. Silibinin is a natural polyphenolic flavonoid isolated from milk thistle with anti-tumor activities, but it was found to induce cytoprotective ROS/RNS in human breast cancer MCF-7 cells. Furthermore, treatment with silibinin down-regulates ERα expression in MCF-7 cells, and inducing both autophagy and apoptosis. In this study we explored the relationship between ER-associated pathways and RNS/ROS in MCF-7 cells...
November 21, 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/27807635/a-review-on-polychlorinated-biphenyls-pcbs-and-polybrominated-diphenyl-ethers-pbdes-in-south-asia-with-a-focus-on-malaysia
#5
Han Yeong Kaw, Narayanan Kannan
Malaysia is a developing country in Southeast Asia, with rapid industrial and economic growth. Speedy population growth and aggressive consumerism in the past five decades have resulted in environmental pollution issues, including products containing polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs). PCBs and PBDEs are classified as persistent organic pollutants (POPs) by the Stockholm Convention due to their persistence, bioaccumulation in the environment and toxicity to humans and wildlife...
November 3, 2016: Reviews of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27796958/purification-of-distinct-subsets-of-epithelial-cells-from-normal-human-breast-tissue
#6
Mona Shehata, John Stingl
The mammary epithelium is composed of a variety of specialized cell types that function in a coordinated fashion to produce and eject milk through multiple cycles of pregnancy. The ability to identify and purify these subsets of cells in order to interrogate their growth and differentiation capacities, as well as to characterize the molecular mechanisms that regulate their behavior, is essential in identifying the processes associated with breast cancer initiation and progression. This methods chapter outlines the step-by-step methods for dissociating human breast reduction specimens to a single cell suspension of viable cells...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27771919/silymarin-and-its-role-in-chronic-diseases
#7
Neha, Amteshwar S Jaggi, Nirmal Singh
Silymarin is the active constituent of Silybum marianum (milk thistle) which is a C-25 containing flavonolignan. Milk thistle has a lot of traditional values, being used as a vegetable, as salad, as bitter tonic, and as galactogogue in nursing mothers and in various ailments such as liver complications, depression, dyspepsia, spleenic congestions, varicose veins, diabetes, amenorrhea, uterine hemorrhage, and menstrual problems. In this present chapter, a comprehensive attempt has been made to discuss the potential of silymarin in chronic disorders...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27765039/dairy-products-intake-and-cancer-mortality-risk-a-meta-analysis-of-11-population-based-cohort-studies
#8
Wei Lu, Hanwen Chen, Yuequn Niu, Han Wu, Dajing Xia, Yihua Wu
BACKGROUND: Dairy products are major components of daily diet and the association between consumption of dairy products and public health issues has captured great attention. In this study, we conducted a meta-analysis to investigate the association between dairy products intake and cancer mortality risk. METHODS: After a literature search in PubMed and EMBASE, 11 population-based cohort studies involving 778,929 individuals were considered eligible and included in the analyses...
October 21, 2016: Nutrition Journal
https://www.readbyqxmd.com/read/27746743/calcium-sensing-receptor-in-breast-physiology-and-cancer
#9
Wonnam Kim, John J Wysolmerski
The calcium-sensing receptor (CaSR) is expressed in normal breast epithelial cells and in breast cancer cells. During lactation, activation of the CaSR in mammary epithelial cells increases calcium transport into milk and inhibits parathyroid hormone-related protein (PTHrP) secretion into milk and into the circulation. The ability to sense changes in extracellular calcium allows the lactating breast to actively participate in the regulation of systemic calcium and bone metabolism, and to coordinate calcium usage with calcium availability during milk production...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27722057/triclosan-in-water-implications-for-human-and-environmental-health
#10
L W B Olaniyan, N Mkwetshana, A I Okoh
Triclosan (TCS) is a broad spectrum antibacterial agent present as an active ingredient in some personal care products such as soaps, toothpastes and sterilizers. It is an endocrine disrupting compound and its increasing presence in water resources as well as in biosolid-amended soils used in farming, its potential for bioaccumulation in fatty tissues and toxicity in aquatic organisms are a cause for concern to human and environmental health. TCS has also been detected in blood, breast milk, urine and nails of humans...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27721540/scorpion-androctonus-bicolor-venom-exhibits-cytotoxicity-and-induces-cell-cycle-arrest-and-apoptosis-in-breast-and-colorectal-cancer-cell-lines
#11
Abdulrahman K Al-Asmari, Anvarbatcha Riyasdeen, Rajamohamed Abbasmanthiri, Mohammed Arshaduddin, Fahad Ali Al-Harthi
OBJECTIVES: The defective apoptosis is believed to play a major role in the survival and proliferation of neoplastic cells. Hence, the induction of apoptosis in cancer cells is one of the targets for cancer treatment. Researchers are considering scorpion venom as a potent natural source for cancer treatment because it contains many bioactive compounds. The main objective of the current study is to evaluate the anticancer property of Androctonus bicolor scorpion venom on cancer cells. MATERIALS AND METHODS: Scorpions were milked by electrical stimulation of telsons and lyophilized...
September 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27684504/risks-profile-and-health-vulnerability-of-cotton-picker-s-women-by-organanochlorine-phosphates-ocps-from-southern-punjab-pakistan
#12
Humaira Yasmeen, Abdul Qadir, Mehvish Mumtaz, Syed Ali Musstjab Akber Shah Eqani, Jabbir Hussain Syed, Adeel Mahmood, Nadia Jamil, Farva Nazar, Habib Ali, Muhammad Shafiq Ahmad, Zafar Iqbal Tanveer, Gan Zhang
The present study was conducted to highlight the existing level of ∑16 OCPs from human milk (n = 45) and blood serum (n = 40) of cotton picker women in Khanewal district, Southern Punjab, Pakistan. Source apportionment, congener specific analysis and risk surveillance of OCPs was reported from human milk and blood samples. Levels of OCPs (ng g(-1) ) in milk and blood serum samples ranged from 15.7 to 538.3 ng g(-1) and 16.4 to 747. 1 ng g(-1) , respectively and was found lower than previously published reports from other regions of the globe...
September 29, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27677719/botanicals-and-their-bioactive-phytochemicals-for-women-s-health
#13
Birgit M Dietz, Atieh Hajirahimkhan, Tareisha L Dunlap, Judy L Bolton
Botanical dietary supplements are increasingly popular for women's health, particularly for older women. The specific botanicals women take vary as a function of age. Younger women will use botanicals for urinary tract infections, especially Vaccinium macrocarpon (cranberry), where there is evidence for efficacy. Botanical dietary supplements for premenstrual syndrome (PMS) are less commonly used, and rigorous clinical trials have not been done. Some examples include Vitex agnus-castus (chasteberry), Angelica sinensis (dong quai), Viburnum opulus/prunifolium (cramp bark and black haw), and Zingiber officinale (ginger)...
October 2016: Pharmacological Reviews
https://www.readbyqxmd.com/read/27673412/effect-of-breast-milk-calcium-and-fluidity-on-breast-cancer-cells-an-in-vitro-cell-culture-study
#14
Recep Bayram, Muhsine Zeynep Yavuz, Bedri Selim Benek, Ayşenur Aydoğar Bozkurt, Ali Ucbek, Zeynep Güneş Özünal, Akçahan Gepdiremen
AIM: The aims of this study were to investigate the effects of calcium at the same concentration as that found in human milk on the viability, proliferation, and adhesion of MCF-7 human breast ductal carcinoma cells by exposing them to calcium at the same frequency as in breastfeeding. MATERIALS AND METHODS: High-concentration calcium was applied for 30 minutes every 4 hours for 24, 48, and 72 hours. Cell proliferation and viability were measured using a hemocytometer and the MTT cell viability assay...
September 27, 2016: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/27669289/using-two-different-approaches-to-assess-dietary-patterns-hypothesis-driven-and-data-driven-analysis
#15
Ágatha Nogueira Previdelli, Samantha Caesar de Andrade, Regina Mara Fisberg, Dirce Maria Marchioni
The use of dietary patterns to assess dietary intake has become increasingly common in nutritional epidemiology studies due to the complexity and multidimensionality of the diet. Currently, two main approaches have been widely used to assess dietary patterns: data-driven and hypothesis-driven analysis. Since the methods explore different angles of dietary intake, using both approaches simultaneously might yield complementary and useful information; thus, we aimed to use both approaches to gain knowledge of adolescents' dietary patterns...
2016: Nutrients
https://www.readbyqxmd.com/read/27651551/attitudes-of-saudi-mothers-towards-breastfeeding
#16
Mashael Alshebly, Badr Sobaih
The aim of the study was to explore the practice and attitudes of Saudi mothers towards breastfeeding. A cross-sectional survey done on a total of 517 Saudi mothers using a questionnaire inquiring about their demographic data, breastfeeding practice in the first 6 months after delivery and longer, different reasons for stopping breastfeeding. Furthermore, their impression on the relation between breastfeeding and breast cancer as well as prevention of infant's allergic and infectious diseases. Only 37.5% of the mothers practiced exclusive breastfeeding for 6 months...
2016: Sudan J Paediatr
https://www.readbyqxmd.com/read/27636835/systematic-evaluation-on-the-effectiveness-of-conjugated-linoleic-acid-in-human-health
#17
Gitane Fuke, José Laerte Nornberg
The term CLA (conjugated linoleic acid) corresponds to a mixture of positional and geometric isomers of linoleic acid. Two of these isomers (9c, 11t and 10t, 12c) have biological activity. The milk and dairy products are the most abundant source of conjugated linoleic acid, which refers to a group of positional and geometric isomers of CLA (CLA 18:2 cis-9, cis-12). The following research aims to approach aspects regarding the CLA, as well as its relationship with diseases. Conjugated linoleic acids have been studied for their beneficial effects in the prevention and treatment of many diseases, including obesity, cancer, diabetes, and cardiovascular diseases...
January 2, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27632371/dairy-calcium-vitamin-d-and-ovarian-cancer-risk-in-african-american-women
#18
Bo Qin, Patricia G Moorman, Anthony J Alberg, Jill S Barnholtz-Sloan, Melissa Bondy, Michele L Cote, Ellen Funkhouser, Edward S Peters, Ann G Schwartz, Paul Terry, Joellen M Schildkraut, Elisa V Bandera
BACKGROUND: No previous study has evaluated the associations of dairy products, lactose, calcium and vitamin D with the risk of ovarian cancer in African-American women, who are known to have high mortality from the disease, as well as to be at risk for calcium and vitamin D deficiency. METHODS: We evaluated these associations among 490 ovarian cancer cases and 656 age- and site-matched controls of African-American descent recruited into the African American Cancer Epidemiology Study, a population-based case-control study in 11 geographical areas in the US...
September 15, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27603890/-cancer
#19
Roberto de la Peña-López, Yuly Andrea Remolina-Bonilla
Cancer is a group of diseases which represents a significant public health problem in Mexico and worldwide. In Mexico neoplasms are the second leading cause of death. An increased morbidity and mortality are expected in the next decades. Several preventable risk factors for cancer development have been identified, the most relevant including tobacco use, which accounts for 30% of the cancer cases; and obesity, associated to another 30%. These factors, in turn, are related to sedentarism, alcohol abuse and imbalanced diets...
September 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27593940/role-of-lactoferrin-in-neonatal-care-a-systematic-review
#20
Deepak Sharma, Sweta Shastri, Pradeep Sharma
BACKGROUND: Lactoferrin (LF) is present in breast milk and have numerous properties including antimicrobial, antiviral, anti-fungal, and anti-cancer. Recent studies have emphasized the role of LF in neonatal care Aims and objective: To evaluate the various roles of Lactoferrin in Neonatal care in preterm infants. SEARCH METHODS: The literature search was done for this systematic review by searching the electronic data base namely Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, Web of Science, Scopus, Index Copernicus, African Index Medicus (AIM), Thomson Reuters (ESCI), Chemical Abstracts Service (CAS), SCIWIN (Scientific World Index), Google Scholar, Latin American and Caribbean Health Sciences Information System (LILACS), Index Medicus for the Eastern Mediterranean Region (IMEMR), Index Medicus for the South-East Asian Region (IMSEAR), Western Pacific Region Index Medicus (WPRIM), various sites for ongoing trials namely clinical trial registry ( www...
September 4, 2016: Journal of Maternal-fetal & Neonatal Medicine
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