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https://www.readbyqxmd.com/read/29345286/cyclooxygenase-2-expression-is-induced-by-celecoxib-treatment-in-lung-cancer-cells-and-is-transferred-to-neighbor-cells-via-exosomes
#1
Jayoung Kim, Seung-Woo Hong, Seonghan Kim, Daejin Kim, Dae Young Hur, Dong-Hoon Jin, Bomi Kim, Yeong Seok Kim
Lung cancer is one of most common types of cancer worldwide. Lung cancer results in a death higher rate each year compared to colon, breast and prostate cancer combined. Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX‑2), an enzyme of which the expression is induced by various stimuli, such as inflammation. In addition, celecoxib triggers COX-2 loading on exosomes. Exosomes are small vesicles composed of a lipid bilayer membrane and are found in most biological fluids, such as blood breast milk and urine...
February 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29340710/production-of-plant-derived-polyphenols-in-microorganisms-current-state-and-perspectives
#2
REVIEW
Lars Milke, Jennifer Aschenbrenner, Jan Marienhagen, Nicolai Kallscheuer
Plants synthesize several thousand different polyphenols of which many have the potential to aid in preventing or treating cancer, cardiovascular, and neurodegenerative diseases. However, plants usually contain complex polyphenol mixtures impeding access to individual compounds in larger quantities. In contrast, functional integration of biosynthetic plant polyphenol pathways into microorganisms allows for the production of individual polyphenols as chemically distinct compounds, which can be synthesized in large amounts and can be more easily isolated...
January 16, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29307071/dietary-exposure-to-hch-and-ddt-congeners-and-their-associated-cancer-risk-based-on-pakistani-food-consumption
#3
Muhammad Aamir, Sardar Khan, Gang Li
Dietary exposure to organochlorine pesticides such as hexachlorocyclohexane (HCH) and dichlorodiphenyltrichloroethane (DDT) congeners was assessed using diet study approach, and for this purpose, different food items were collected in August 2014. The levels of ∑(HCHs + DDTs) in different food groups were ranged from 2.57 to 206 ng g-1, ww, with contamination order of fish > poultry > milk > vegetables > cereals > flour > fruits. In the present study, the ratios of β-HCH/∑HCH (0.19-0...
January 6, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29283380/dairy-products-intake-and-endometrial-cancer-risk-a-meta-analysis-of-observational-studies
#4
Xiaofan Li, Jing Zhao, Peiqin Li, Ying Gao
Observational studies have suggested inconsistent findings on the relationship between dairy products intake and endometrial cancer risk. This study aimed to conduct a meta-analysis to evaluate this correlation; moreover, databases including PubMed, ISI Web of Science, and Embase were screened for relevant studies up to 26 February 2017. The inverse variance weighting method and random effects models were used to calculate the overall OR (odds ratio) values and 95% confidence interval (CI). A total of 2 cohort study and 16 case-control studies were included in the current analysis...
December 28, 2017: Nutrients
https://www.readbyqxmd.com/read/29241749/acne-vulgaris-the-metabolic-syndrome-of-the-pilosebaceous-follicle
#5
Bodo C Melnik
Acne vulgaris is an epidemic inflammatory disease of the human sebaceous follicle and represents the most common skin disease affecting about 85% of adolescents in Westernized populations. Acne vulgaris is primarily a disease of wealthy countries and exhibits higher prevalence rates in developed compared with developing countries. No acne has been found in non-Westernized populations still living under Paleolithic dietary conditions constraining hyperglycemic carbohydrates, milk, and dairy products. The high prevalence rates of adolescent acne cannot be explained by the predominance of genetic factors but by the influence of a Western diet that overstimulates the key conductor of metabolism, the nutrient- and growth factor-sensitive kinase mTORC1...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29240674/evaluation-of-the-cytotoxicity-and-genotoxicity-of-flavonolignans-in-different-cellular-models
#6
Michal Bijak, Ewelina Synowiec, Przemyslaw Sitarek, Tomasz Sliwiński, Joanna Saluk-Bijak
Flavonolignans are the main components of silymarin, which represents 1.5-3% of the dry fruit weight of Milk thistle (Silybum marianum L. Gaernt.). In ancient Greece and Romania, physicians and herbalists used the Silybum marianum to treat a range of liver diseases. Besides their hepatoprotective action, silymarin flavonolignans have many other healthy properties, such as anti-platelet and anti-inflammatory actions. The aim of this study was to evaluate the toxic effect of flavonolignans on blood platelets, peripheral blood mononuclear cells (PBMCs) and human lung cancer cell line-A549-using different molecular techniques...
December 14, 2017: Nutrients
https://www.readbyqxmd.com/read/29228605/a-case-control-study-on-risk-factors-of-breast-cancer-in-han-chinese-women
#7
Li-Yuan Liu, Fei Wang, Shu-De Cui, Fu-Guo Tian, Zhi-Min Fan, Cui-Zhi Geng, Xu-Chen Cao, Zhen-Lin Yang, Xiang Wang, Hong Liang, Shu Wang, Hong-Chuan Jiang, Xue-Ning Duan, Hai-Bo Wang, Guo-Lou Li, Qi-Tang Wang, Jian-Guo Zhang, Feng Jin, Jin-Hai Tang, Liang Li, Shi-Guang Zhu, Wen-Shu Zuo, Li-Xiang Yu, Yu-Juan Xiang, Fei Zhou, Liang Li, Qiang Zhang, Qin-Ye Fu, Zhong-Bing Ma, De-Zong Gao, Yu-Yang Li, Lu Liu, Chun-Miao Ye, Yong-Jiu Wang, Wen-Zhong Zhou, Zhi-Gang Yu
This study aimed to investigate risk factors associated with breast cancer among Han Chinese women in northern and eastern China. A matched case-control study involving 1489 patients with breast cancer and 1489 controls was conducted across 21 hospitals in 11 provinces in China, from April 2012 to April 2013. We developed a structured questionnaire to record information from face-to-face interviews with participants. Student's t-tests, Pearson's chi-square tests, and univariate and multivariate conditional logistic regression analyses were used to identify variables with significant differences between the case and control groups...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29216556/influence-of-water-activity-and-temperature-on-growth-and-fumonisin-production-by-fusarium-proliferatum-strains-on-irradiated-wheat-grains
#8
Eugenia Cendoya, María Del Pilar Monge, Stella Maris Chiacchiera, María Cecilia Farnochi, María Laura Ramirez
Wheat is the most important cereal consumed by the Argentine population. In previous studies performed in durum and common wheat grains in this country it has been observed fumonisin contamination as well as high incidence of Fusarium proliferatum. Fumonisins are toxic fungal metabolites, and consumption of fumonisin-contaminated maize has been epidemiologically associated with oesophageal cancer and neural tube defects in some human populations. Using irradiated wheat-grains, the effects of abiotic factors, temperature (15, 25, and 30°C) and water activity (aW; 0...
December 4, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29211694/prevention-of-bladder-cancer-incidence-and-recurrence-nutrition-and-lifestyle
#9
Christian D Fankhauser, Hugh Mostafid
PURPOSE OF REVIEW: We review the influence of nutrition and lifestyle on bladder cancer incidence and recurrence and summarize food items, diets and lifestyle practices that physicians may wish to prioritize for discussion with their patients. RECENT FINDINGS: Recent study results suggest an association between bladder cancer incidence and several food items including meat, fruit, vegetables, milk products and oil. Micronutrient deficiency is associated with bladder cancer risk; however, it remains unclear if micronutrient supplementation can modify bladder cancer incidence...
January 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29204733/comparative-nutritional-and-mycochemical-contents-biological-activities-and-lc-ms-screening-of-tuber-from-new-recipe-cultivation-technique-with-wild-type-tuber-of-tiger-s-milk-mushroom-of-species-lignosus-rhinocerus
#10
Nor Azreen Mohd Jamil, Noraswati Mohd Nor Rashid, Mohamad Hasril Abd Hamid, Norasfaliza Rahmad, Jameel R Al-Obaidi
Tiger's milk mushroom is known for its valuable medicinal properties, especially the tuber part. However, wild tuber is very hard to obtain as it grows underground. This study first aimed to cultivate tiger's milk mushroom tuber through a cultivation technique, and second to compare nutritional and mycochemical contents, antioxidant and cytotoxic activities and compound screening of the cultivated tuber with the wild tuber. Results showed an increase in carbohydrate content by 45.81% and protein content by 123...
December 4, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29200713/gastroprotective-and-ulcer-healing-effects-of-camel-milk-and-urine-in-hcl-etoh-non-steroidal-anti-inflammatory-drugs-indomethacin-and-water-restraint-stress-induced-ulcer-in-rats
#11
Zijuan Hu, Xiaoman Chang, Qing Pan, Kebin Gu, Patrick Nwabueze Okechukwu
Background: Camel milk has been reportedly used to treat dropsy, jaundice, tuberculosis, and diabetes while camel urine is used to treat diarrhea and cancer. However, there is no scientific evidence on the antiulcer activity of camel milk and urine. Thus, the present is designed to investigate the gastroprotective and ulcer healing effect of camel milk and urine on experimentally induced gastric ulcer models in rats. Materials and Methods: The gastroprotective effect was investigated in HCl/EtOH, water-restraint stress (WRS) and non-steroidal anti-inflammatory drugs (indomethacin)-induced ulcer models while ulcer healing activity was investigated in indomethacin-induced ulcer model...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29196676/efficiency-of-novel-nanocombinations-of-bovine-milk-proteins-lactoperoxidase-and-lactoferrin-for-combating-different-human-cancer-cell-lines
#12
Marwa M Abu-Serie, Esmail M El-Fakharany
Bovine lactoperoxidase (LPO) and lactoferrin (LF) are suitable proteins to be loaded or adsorbed to chitosan nanoparticles (NPs) for preparing stable nanoformulations with potent anticancer activity. In the present study, nanocombinations of LPO and LF revealed improvement in their stability and activity compared to single (free or nanoformulated) bovine proteins. The coating or loading of LPO-loaded NPs with LF resulted in the highest synergistic cytotoxicity effect against Caco-2, HepG-2, MCF-7 and PC-3 cells in comparison with other NPs and free proteins without causing toxicity toward normal cells...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29193311/proteomics-analysis-of-human-breast-milk-to-assess-breast-cancer-risk
#13
Roshanak Aslebagh, Devika Channaveerappa, Kathleen F Arcaro, Costel C Darie
Detection of breast cancer (BC) in young women is challenging because mammography, the most common tool for detecting BC, is not effective on the dense breast tissue characteristic of young women. In addition to the limited means for detecting their BC, young women face a transient increased risk of pregnancy-associated BC. As a consequence, reproductively active women could benefit significantly from a tool that provides them with accurate risk assessment and early detection of BC. One potential method for detection of BC is biochemical monitoring of proteins and other molecules in bodily fluids such as serum, nipple aspirate, ductal lavage, tear, urine, saliva and breast milk...
November 29, 2017: Electrophoresis
https://www.readbyqxmd.com/read/29190895/silibinin-suppresses-bladder-cancer-through-down-regulation-of-actin-cytoskeleton-and-pi3k-akt-signaling-pathways
#14
Mitsuho Imai-Sumida, Takeshi Chiyomaru, Shahana Majid, Sharanjot Saini, Hannah Nip, Rajvir Dahiya, Yuichiro Tanaka, Soichiro Yamamura
Silibinin is the major active constituent of silymarin, an extract of milk thistle seeds. Silibinin has been shown to have significant anti-cancer effects in a variety of malignancies. However, the molecular mechanisms of silibinin action in bladder cancer have not been studied extensively. In the present study, we found that silibinin (10 μM) significantly suppressed proliferation, migration, invasion and induced apoptosis of T24 and UM-UC-3 human bladder cancer cells. Silibinin down-regulated the actin cytoskeleton and phosphatidylinositide 3-kinase (PI3K)/Akt signaling pathways in these cancer cell lines...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29185928/dietary-intake-nutritional-status-and-mental-wellbeing-of-homeless-adults-in-reading-uk
#15
Rosalind Fallaize, Josephine V Seale, Charlotte Mortin, Lisha Armstrong, Julie A Lovegrove
Malnutrition has been reported in the homeless, yet the specific nutritional issues faced by each homeless community are unclear. This is in part due to nutrient intake often being compared with dietary reference values as opposed to a comparative housed population. In addition, the complex interplay between nutrient intake, reward mediated behaviour and mental illness is frequently overlooked. This study aimed to compare the dietary intake, nutritional status and mental wellbeing of homeless and housed adults...
November 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29183385/an-investigation-into-aflatoxin-m-1-in-slaughtered-fattening-pigs-and-awareness-of-aflatoxins-in-vietnam
#16
Hu Suk Lee, Johanna Lindahl, Hung Nguyen-Viet, Nguyen Viet Khong, Vuong Bui Nghia, Huyen Nguyen Xuan, Delia Grace
BACKGROUND: Aflatoxin M1 (AFM1) is a hydroxylated metabolite formed after aflatoxin B1 (AFB1) is consumed by humans and animals; it can be detected in urine, milk and blood. It is well recognized that AFB1 is toxic to humans and other animals. The International Agency for Research on Cancer (IARC) classifies aflatoxins as group 1 carcinogens and AFM1 as group 2B carcinogen. The main objective of this study was to evaluate the exposure of pigs to aflatoxins as well as to assess the public awareness of aflatoxins among people in five provinces in Vietnam...
November 28, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29173212/substitutions-between-dairy-product-subgroups-and-risk-of-type-2-diabetes-the-danish-diet-cancer-and-health-cohort
#17
Daniel B Ibsen, Anne Sofie D Laursen, Lotte Lauritzen, Anne Tjønneland, Kim Overvad, Marianne U Jakobsen
The aim of this study was to investigate the associations for specified substitutions between different subgroups of dairy products and the risk of type 2 diabetes. We used data from the Danish Diet, Cancer and Health cohort including 54 277 men and women aged 50-64 years at baseline. Information regarding intake of dairy products was obtained from a validated FFQ, and cases of type 2 diabetes were identified through the Danish National Diabetes Register. Cox proportional hazards regressions were used to estimate associations...
November 27, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29152146/breast-tissue-oral-and-urinary-microbiomes-in-breast-cancer
#18
Hannah Wang, Jessica Altemus, Farshad Niazi, Holly Green, Benjamin C Calhoun, Charles Sturgis, Stephen R Grobmyer, Charis Eng
It has long been proposed that the gut microbiome contributes to breast carcinogenesis by modifying systemic estrogen levels. This is often cited as a possible mechanism linking breast cancer and high-fat, low-fiber diets as well as antibiotic exposure, associations previously identified in population-based studies. More recently, a distinct microbiome has been identified within breast milk and tissue, but few studies have characterized differences in the breast tissue microbiota of patients with and without cancer, and none have investigated distant body-site microbiomes outside of the gut...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29142587/factors-associated-with-the-high-prevalence-of-oesophageal-cancer-in-western-kenya-a-review
#19
REVIEW
Gabriel Kigen, Naftali Busakhala, Zipporah Kamuren, Hillary Rono, Wilfred Kimalat, Evangeline Njiru
Oesophageal carcinoma (OC) is highly prevalent in Western Kenya especially among the members of the Kalenjin community who reside in the Northern and Southern areas of the Rift Valley. Previous authors have suggested potential association of environmental and genetic risk factors with this high prevalence. The environmental factors that have been suggested include contamination of food by mycotoxins and/or pesticides, consumption of traditional alcohol (locally referred to "Busaa" and "Chan'gaa"), use of fermented milk ("Mursik"), poor diet, tobacco use and genetic predisposition...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29129231/the-association-between-the-index-of-nutritional-quality-inq-and-breast-cancer-and-the-evaluation-of-nutrient-intake-of-breast-cancer-patients-a-case-control-study
#20
Farhad Vahid, Mahshid Hatami, Mahya Sadeghi, Fatemeh Ameri, Zeinab Faghfoori, Sayed Hossein Davoodi
OBJECTIVE: Breast cancer (BrCa) is the most frequently diagnosed cancer among females and second cancer after lung cancer in many societies. In Iran, the risk for BrCa is 1 in 35 and each year, 8000 new patients have been diagnosed with BrCa. Studies have shown that dietary components are implicated in the etiology of BrCa. The Index of Nutritional Quality (INQ) is a method of quantitative and qualitative analysis of single foods, meals, and diets. The aim of this study was to determine the usefulness of INQs in predicting BrCa risk...
January 2018: Nutrition
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