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https://www.readbyqxmd.com/read/28070314/calories-and-sugars-in-boba-milk-tea-implications-for-obesity-risk-in-asian-pacific-islanders
#1
Jae Eun Min, David B Green, Loan Kim
In the last several decades, obesity rates have reached epidemic proportions, and increases the risk for a host of comorbidities, including diabetes, cardiovascular disease, and certain kinds of cancers. Boba milk tea, first became popular in the 1990s throughout Asia, and has gained more popularity in the United States and in Europe since 2000. Currently, available nutrition data from online sites suggest this beverage contains high amounts of sugar and fat. One published nutrition study suggests that boba tea drinks are part of the larger group of sugar-sweetened beverages (SSB) because these beverages are usually sweetened with high-fructose corn syrup (HFCS)...
January 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28042859/a-novel-role-of-silibinin-as-a-putative-epigenetic-modulator-in-human-prostate-carcinoma
#2
Ioannis Anestopoulos, Aristeidis P Sfakianos, Rodrigo Franco, Katerina Chlichlia, Mihalis I Panayiotidis, David J Kroll, Aglaia Pappa
Silibinin, extracted from milk thistle (Silybum marianum L.), has exhibited considerable preclinical activity against prostate carcinoma. Its antitumor and chemopreventive activities have been associated with diverse effects on cell cycle, apoptosis, and receptor-dependent mitogenic signaling pathways. Here we hypothesized that silibinin's pleiotropic effects may reflect its interference with epigenetic mechanisms in human prostate cancer cells. More specifically, we have demonstrated that silibinin reduces gene expression levels of the Polycomb Repressive Complex 2 (PRC2) members Enhancer of Zeste Homolog 2 (EZH2), Suppressor of Zeste Homolog 12 (SUZ12), and Embryonic Ectoderm Development (EED) in DU145 and PC3 human prostate cancer cells, as evidenced by Real Time Polymerase Chain Reaction (RT-PCR)...
December 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28002682/human-milk-and-matched-serum-demonstrate-concentration-of-select-mirnas
#3
Wenyi Qin, Santanu Dasgupta, John Corradi, Edward R Sauter
BACKGROUND: Pregnancy-associated breast cancers (PABCs), especially those diagnosed after childbirth, are often aggressive, with a poor prognosis. Factors influencing PABC are largely unknown. Micro(mi)RNAs are present in many human body fluids and shown to influence cancer development and/or growth. SUBJECTS AND METHODS: In six nursing mothers, we determined if breast cancer-associated miRNAs were (1) detectable in human breast milk and (2) if detectable, their relative expression in milk fractions compared to matched serum...
December 21, 2016: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/27990698/dietary-strategies-for-achieving-adequate-vitamin-d-and-iron-intakes-in-young-children-in-ireland
#4
L Kehoe, J Walton, B A McNulty, A P Nugent, A Flynn
BACKGROUND: Inadequate intakes of vitamin D and iron have been reported in young children in Ireland. The present study aimed to identify the main foods determining vitamin D and iron intakes and to model the impact of dietary strategies to improve adequacy of these micronutrients in young children. METHODS: The present study is based on the Irish National Pre-School Nutrition Survey (NPNS), which estimated food and nutrient intakes in a representative sample (n = 500) of children (aged 1-4 years) using a 4-day weighed food record...
December 18, 2016: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/27982091/a-detergent-based-procedure-for-the-preparation-of-igg-like-bispecific-antibodies-in-high-yield
#5
Jyoti Gupta, Mehboob Hoque, Masihuz Zaman, Rizwan Hasan Khan, M Saleemuddin
Bispecific antibodies (BsAbs), with the ability to recognize two different epitopes simultaneously, offer remarkable advantages in bioassays, cancer therapy, biosensors, and enzyme electrodes. Preparation and purification of BsAbs in adequate quantities remains a major hurdle in their use in various applications. Poor yield is also the principal limitation in the preparation of BsAbs by the redox procedure. IgG with reduced inter-heavy chain disulfides do not dissociate into half molecules at neutral pH. In this study, we report that the dissociation occurs in presence of sodium dodecyl sulphate (SDS) and inclusion of the detergent during the redox procedure results in remarkable increase in the formation of the BsAbs...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27974606/dairy-food-intake-is-inversely-associated-with-risk-of-hypertension-the-singapore-chinese-health-study
#6
Mohammad Talaei, An Pan, Jian-Min Yuan, Woon-Puay Koh
BACKGROUND: Epidemiological evidence from Western populations suggests that dairy food intake may reduce the risk of hypertension, probably through its calcium content. However, there are no epidemiological studies among Asian populations with generally lower dairy and calcium consumption. OBJECTIVE: The relation between dairy or calcium intake and risk of hypertension was evaluated in a Chinese population in Singapore. METHODS: The analysis included 37,124 Chinese men and women aged 45-74 y who participated in the Singapore Chinese Health Study in 1993-1998...
December 14, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27968878/dietary-patterns-and-risk-of-breast-cancer-in-chinese-women-a-population-based-case-control-study
#7
Shurong Lu, Xingyu Huang, Hao Yu, Jie Yang, Renqiang Han, Jian Su, Wencong Du, Jinyi Zhou, Xiaojin Yu, Ming Wu
BACKGROUND: The incidence rate of breast cancer has markedly increased in recent years in China, yet the association of breast cancer with dietary patterns such as a Chinese traditional diet has not been studied. We aimed to examine this association among women from the Jiangsu Province of China. METHODS: In this case-control study, we used the data from local population-based cancer registry agency to recruit newly diagnosed patients with primary breast cancer as cases...
October 2016: Lancet
https://www.readbyqxmd.com/read/27939550/invited-review-microbe-mediated-aflatoxin-decontamination-of-dairy-products-and-feeds
#8
Sejeong Kim, Heeyoung Lee, Soomin Lee, Jeeyeon Lee, Jimyeong Ha, Yukyung Choi, Yohan Yoon, Kyoung-Hee Choi
Aspergillus flavus, Aspergillus parasiticus, and Aspergillus nomius contaminate corn, sorghum, rice, peanuts, tree nuts, figs, ginger, nutmeg, and milk. They produce aflatoxins, especially aflatoxin B1, which is classified as a Group 1 carcinogen by the International Agency for Research on Cancer. Many studies have focused on aflatoxin removal from food or feed, especially via microbe-mediated mechanisms-either adsorption or degradation. Of the lactic acid bacteria, Lactobacillus rhamnosus GG efficiently binds aflatoxin B1, and a peptidoglycan in the bacterium cell wall plays an important role...
December 8, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27894063/loss-of-glutaredoxin-3-impedes-mammary-lobuloalveolar-development-during-pregnancy-and-lactation
#9
Khanh Pham, Jie Dong, Xiqian Jiang, Ying Qu, Han Yu, Yisheng Yang, Walter Olea, Juan C Marini, Lawrence Chan, Jin Wang, Xander H T Wehrens, Xiaojiang Cui, Yi Li, Darryl L Hadsell, Ninghui Cheng
Mammalian glutaredoxin 3 (Grx3) has been shown to be important for regulating cellular redox homeostasis in the cell. Our previous studies indicate that Grx3 is significantly overexpressed in various human cancers including breast cancer and demonstrate that Grx3 controls cancer cell growth and invasion by regulating ROS and NF-κB signaling pathways. However, it remains to be determined whether Grx3 is required for normal mammary gland development and how it contributes to epithelial cell proliferation and differentiation in vivo In the present study, we examined Grx3 expression in different cell types within the developing mouse mammary gland (MG) and found enhanced expression of Grx3 at pregnancy and lactation stages...
November 15, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27882862/milk-and-dairy-products-good-or-bad-for-human-health-an-assessment-of-the-totality-of-scientific-evidence
#10
REVIEW
Tanja Kongerslev Thorning, Anne Raben, Tine Tholstrup, Sabita S Soedamah-Muthu, Ian Givens, Arne Astrup
BACKGROUND: There is scepticism about health effects of dairy products in the public, which is reflected in an increasing intake of plant-based drinks, for example, from soy, rice, almond, or oat. OBJECTIVE: This review aimed to assess the scientific evidence mainly from meta-analyses of observational studies and randomised controlled trials, on dairy intake and risk of obesity, type 2 diabetes, cardiovascular disease, osteoporosis, cancer, and all-cause mortality...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27869663/dietary-protein-sources-and-incidence-of-breast-cancer-a-dose-response-meta-analysis-of-prospective-studies
#11
Jing Wu, Rong Zeng, Junpeng Huang, Xufeng Li, Jiren Zhang, James Chung-Man Ho, Yanfang Zheng
Protein is important to the human body, and different sources of protein may have different effects on the risk of breast cancer. Thus, we conducted a meta-analysis to investigate the association between different dietary protein sources and breast cancer risk. PubMed and several databases were searched until December 2015. Relevant articles were retrieved according to specific searching criteria. Forty-six prospective studies were included. The summary relative risk (RR) for highest versus lowest intake was 1...
November 17, 2016: Nutrients
https://www.readbyqxmd.com/read/27867187/crosstalk-of-ros-rns-and-autophagy-in-silibinin-induced-apoptosis-of-mcf-7-human-breast-cancer-cells-in-vitro
#12
Nan Zheng, Lu Liu, Wei-Wei Liu, Fei Li, Toshihiko Hayashi, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejima
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles in regulating cell survival and death. Silibinin is a natural polyphenolic flavonoid isolated from milk thistle with anti-tumor activities, but it was found to induce cytoprotective ROS/RNS in human breast cancer MCF-7 cells. Furthermore, treatment with silibinin down-regulates ERα expression in MCF-7 cells, and inducing both autophagy and apoptosis. In this study we explored the relationship between ER-associated pathways and RNS/ROS in MCF-7 cells...
November 21, 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/27807635/a-review-on-polychlorinated-biphenyls-pcbs-and-polybrominated-diphenyl-ethers-pbdes-in-south-asia-with-a-focus-on-malaysia
#13
Han Yeong Kaw, Narayanan Kannan
Malaysia is a developing country in Southeast Asia, with rapid industrial and economic growth. Speedy population growth and aggressive consumerism in the past five decades have resulted in environmental pollution issues, including products containing polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs). PCBs and PBDEs are classified as persistent organic pollutants (POPs) by the Stockholm Convention due to their persistence, bioaccumulation in the environment and toxicity to humans and wildlife...
2017: Reviews of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27796958/purification-of-distinct-subsets-of-epithelial-cells-from-normal-human-breast-tissue
#14
Mona Shehata, John Stingl
The mammary epithelium is composed of a variety of specialized cell types that function in a coordinated fashion to produce and eject milk through multiple cycles of pregnancy. The ability to identify and purify these subsets of cells in order to interrogate their growth and differentiation capacities, as well as to characterize the molecular mechanisms that regulate their behavior, is essential in identifying the processes associated with breast cancer initiation and progression. This methods chapter outlines the step-by-step methods for dissociating human breast reduction specimens to a single cell suspension of viable cells...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27771919/silymarin-and-its-role-in-chronic-diseases
#15
Neha, Amteshwar S Jaggi, Nirmal Singh
Silymarin is the active constituent of Silybum marianum (milk thistle) which is a C-25 containing flavonolignan. Milk thistle has a lot of traditional values, being used as a vegetable, as salad, as bitter tonic, and as galactogogue in nursing mothers and in various ailments such as liver complications, depression, dyspepsia, spleenic congestions, varicose veins, diabetes, amenorrhea, uterine hemorrhage, and menstrual problems. In this present chapter, a comprehensive attempt has been made to discuss the potential of silymarin in chronic disorders...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27765039/dairy-products-intake-and-cancer-mortality-risk-a-meta-analysis-of-11-population-based-cohort-studies
#16
Wei Lu, Hanwen Chen, Yuequn Niu, Han Wu, Dajing Xia, Yihua Wu
BACKGROUND: Dairy products are major components of daily diet and the association between consumption of dairy products and public health issues has captured great attention. In this study, we conducted a meta-analysis to investigate the association between dairy products intake and cancer mortality risk. METHODS: After a literature search in PubMed and EMBASE, 11 population-based cohort studies involving 778,929 individuals were considered eligible and included in the analyses...
October 21, 2016: Nutrition Journal
https://www.readbyqxmd.com/read/27746743/calcium-sensing-receptor-in-breast-physiology-and-cancer
#17
REVIEW
Wonnam Kim, John J Wysolmerski
The calcium-sensing receptor (CaSR) is expressed in normal breast epithelial cells and in breast cancer cells. During lactation, activation of the CaSR in mammary epithelial cells increases calcium transport into milk and inhibits parathyroid hormone-related protein (PTHrP) secretion into milk and into the circulation. The ability to sense changes in extracellular calcium allows the lactating breast to actively participate in the regulation of systemic calcium and bone metabolism, and to coordinate calcium usage with calcium availability during milk production...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27722057/triclosan-in-water-implications-for-human-and-environmental-health
#18
L W B Olaniyan, N Mkwetshana, A I Okoh
Triclosan (TCS) is a broad spectrum antibacterial agent present as an active ingredient in some personal care products such as soaps, toothpastes and sterilizers. It is an endocrine disrupting compound and its increasing presence in water resources as well as in biosolid-amended soils used in farming, its potential for bioaccumulation in fatty tissues and toxicity in aquatic organisms are a cause for concern to human and environmental health. TCS has also been detected in blood, breast milk, urine and nails of humans...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27721540/scorpion-androctonus-bicolor-venom-exhibits-cytotoxicity-and-induces-cell-cycle-arrest-and-apoptosis-in-breast-and-colorectal-cancer-cell-lines
#19
Abdulrahman K Al-Asmari, Anvarbatcha Riyasdeen, Rajamohamed Abbasmanthiri, Mohammed Arshaduddin, Fahad Ali Al-Harthi
OBJECTIVES: The defective apoptosis is believed to play a major role in the survival and proliferation of neoplastic cells. Hence, the induction of apoptosis in cancer cells is one of the targets for cancer treatment. Researchers are considering scorpion venom as a potent natural source for cancer treatment because it contains many bioactive compounds. The main objective of the current study is to evaluate the anticancer property of Androctonus bicolor scorpion venom on cancer cells. MATERIALS AND METHODS: Scorpions were milked by electrical stimulation of telsons and lyophilized...
September 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27684504/risks-profile-and-health-vulnerability-of-cotton-picker-s-women-by-organanochlorine-phosphates-ocps-from-southern-punjab-pakistan
#20
Humaira Yasmeen, Abdul Qadir, Mehvish Mumtaz, Syed Ali Musstjab Akber Shah Eqani, Jabbir Hussain Syed, Adeel Mahmood, Nadia Jamil, Farva Nazar, Habib Ali, Muhammad Shafiq Ahmad, Zafar Iqbal Tanveer, Gan Zhang
The present study was conducted to highlight the existing level of ∑16 OCPs from human milk (n = 45) and blood serum (n = 40) of cotton picker women in Khanewal district, Southern Punjab, Pakistan. Source apportionment, congener specific analysis and risk surveillance of OCPs was reported from human milk and blood samples. Levels of OCPs (ng g(-1) ) in milk and blood serum samples ranged from 15.7 to 538.3 ng g(-1) and 16.4 to 747. 1 ng g(-1) , respectively and was found lower than previously published reports from other regions of the globe...
September 29, 2016: Environmental Toxicology and Chemistry
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