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https://www.readbyqxmd.com/read/28488344/nipple-aspirate-fluid-a-liquid-biopsy-for-diagnosing-breast-health
#1
Sadr-Ul Shaheed, Catherine Tait, Kyriacos Kyriacou, Joanne Mullarkey, Wayne Burrill, Laurence H Patterson, Richard Linforth, Mohamed Salhab, Chris Sutton
PURPOSE: Nipple secretions are protein-rich and a potential source of breast cancer biomarkers for breast cancer screening. Previous studies of specific proteins have shown limited correlation with clinicopatholigical features. Our aim, in this pilot study, was to investigate the intra- and inter-patient protein composition of nipple secretions and the implications for their use as liquid biopsies. EXPERIMENTAL DESIGN: Matched pairs of NAF (n = 15) were characterised for physicochemical properties and SDS PAGE...
May 10, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28473429/atraumatic-chylous-ascites-an-unusual-presentation-of-bladder-cancer
#2
Ashish Srinivasan, Ross Apostolov, Amanda Leong, Douglas Johnson
We describe a case of bladder cancer presenting with atraumatic chylous ascites, which remains an extremely rare presentation of this condition. A previously well, elderly ex-smoker with no prior history of abdominal surgery was referred for investigation of progressive dyspnoea, increasing peripheral oedema and new-onset ascites, on a background of long-standing alcohol consumption (four standard drinks daily). Liver biochemistry and coagulation profile were normal apart from marked hypoalbuminaemia. Doppler ultrasound of the liver demonstrated normal echotexture and patent vasculature...
May 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28467661/circulating-insulin-like-growth-factor-related-biomarkers-correlates-and-responses-to-calcium-supplementation-in-colorectal-adenoma-patients
#3
Caroline Y Um, Veronika Fedirko, W Dana Flanders, Christine Höflich, Elisa Wirthgen, Roberd M Bostick
Circulating insulin-like growth factor 1 (IGF-1) may be directly associated with colorectal cancer risk, and IGF binding protein 3 (IGFBP-3) is one of the most abundantly expressed binding proteins in various cancers. Calcium intakes, primarily from food, have been directly associated with circulating IGF-1, but whether supplemental calcium affects IGF-1 and IGFBP-3 is unknown. We tested the effects of 1.0 and 2.0 g of supplemental elemental calcium daily on circulating IGF-1 and IGFBP-3 concentrations in colorectal adenoma patients in a randomized, double-blinded, placebo-controlled clinical trial (n = 193)...
May 3, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28466508/adverse-child-health-impacts-resulting-from-food-adulterations-in-the-greater-china-region
#4
REVIEW
W C Li, C F Chow
Food adulteration has a long history in human society, and it still occurs in modern times. Because children are relatively vulnerable to food adulterants, studying the health impacts of food adulteration on children is important. This article provides an overview of the child health impacts of food adulterants in two recent food adulteration incidents in the Greater China Region: 1) a plasticizer incident in Taiwan and 2) a 2,4,6-triamino-1,3,5-triazine (melamine)-tainted milk incident in China. The involved food adulterants (bis(2-ethylhexyl) phthalate [DEHP], diisononyl phthalate [DiNP] and melamine) are harmful to the hippocampus, kidneys, reproductive organs, and immune system of children, and they also increase the risk of cancer...
May 2, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28450523/isolation-of-two-virus-like-circular-dnas-from-commercially-available-milk-samples
#5
Konstantina Falida, Sebastian Eilebrecht, Karin Gunst, Harald Zur Hausen, Ethel-Michele de Villiers
Epidemiological data indicate a potential relationship between milk and dairy product consumption and the incidence of breast cancer, as well as neurodegenerative diseases. We report the isolation of two novel circular DNA molecules isolated from commercially available milk.
April 27, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28434726/short-communication-sensory-analysis-of-a-kefir-product-designed-for-active-cancer-survivors
#6
K O'Brien, C Boeneke, W Prinyawiwatkul, J Lisano, D Shackelford, K Reeves, M Christensen, R Hayward, K Carabante Ordonez, L K Stewart
Kefir is a fermented milk product that is a good source of protein and health-promoting bacteria. It has the potential to improve recovery from exercise, and the health and well-being of cancer survivors. The purpose of this study was to explore cancer survivor attitudes about and acceptance of a kefir recovery beverage made from cultured milk, whole fruit, natural sweeteners, and other natural ingredients. Kefir was made by inoculating and fermenting milk with kefir grains. The kefir was then mixed with a fruit base and given to cancer survivors (n = 52) following a bout of exercise...
April 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28410222/dietary-score-and-the-risk-of-oral-cancer-a-case-control-study-in-southeast-china
#7
Fa Chen, Lingjun Yan, Lisong Lin, Fengqiong Liu, Yu Qiu, Jing Wang, Junfeng Wu, Fangping Liu, Jiangfeng Huang, Lin Cai, Baochang He
This study aims to develop a simple dietary score to comprehensively evaluate the role of diet in the risk of oral cancer. A case-control study including 930 oral cancer cases and 2667 frequency-matched controls was performed in Fujian, China. Unconditional logistic regression model was used to estimate the effects of dietary factors on oral cancer. After adjustment for potential confounders, less intake of domestic meat (< 3 times per week), fish (< 3 times per week), seafood (< 3 times per week), leafy vegetables (< 1 time per day), other vegetables (< 1 time per day), fruits (< 3 times per week), milk and dairy products (< 1 time per week) and eggs (< 5 times per week) were significant risk factors for oral cancer...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28407090/foods-and-beverages-and-colorectal-cancer-risk-a-systematic-review-and-meta-analysis-of-cohort-studies-an-update-of-the-evidence-of-the-wcrf-aicr-continuous-update-project
#8
A R Vieira, L Abar, Dsm Chan, S Vingeliene, E Polemiti, C Stevens, D Greenwood, T Norat
Objective: As part of the World Cancer Research Fund International Continuous Update Project, we updated the systematic review and meta-analysis of prospective studies to quantify the dose-response between foods and beverages intake and colorectal cancer risk. Data Sources: PubMed and several databases up to May 31 st 2015. Study selection: Prospective studies reporting adjusted relative risk estimates for the association of specific food groups and beverages and risk of colorectal, colon and rectal cancer...
April 12, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28393675/assessment-risk-to-children-s-health-due-to-consumption-of-cow-s-milk-in-polluted-areas-in-puebla-and-tlaxcala-m%C3%A3-xico
#9
Numa Pompilio Castro Gonzalez, Rafael Moreno-Rojas, Francisco Calderón Sánchez, Alicia Moreno Ortega, Mayté Juarez Meneses
This study aimed to determine the heavy metal content in cow's milk produced in areas irrigated with wastewater and to evaluate the risk to the health of children by the consumption of it. The sample consisted of four zones in which small farmers were selected and the milk of 160 cows in two seasons of the year. On average, the metals in the milk in decreasing order were 0.36; 0.046; 0.035; 0.029; 0.015; 0.012 and 0.002 mg kg (-1) for Zn, Pb, As, Cu, Cr, Ni and Cd, respectively. The Pb exceeded the limits allowed by Codex...
April 10, 2017: Food Additives & Contaminants. Part B, Surveillance
https://www.readbyqxmd.com/read/28369205/dairy-food-intake-and-all-cause-cardiovascular-disease-and-cancer-mortality-the-golestan-cohort-study
#10
Maryam S Farvid, Akbar F Malekshah, Akram Pourshams, Hossein Poustchi, Sadaf G Sepanlou, Maryam Sharafkhah, Masoud Khoshnia, Mojtaba Farvid, Christian C Abnet, Farin Kamangar, Sanford M Dawsey, Paul Brennan, Paul D Pharoah, Paolo Boffetta, Walter C Willett, Reza Malekzadeh
We investigated the association between dairy product consumption and all-cause, cardiovascular disease (CVD), and cancer mortality in the Golestan Cohort Study, a prospective cohort study launched in January 2004 in Golestan Province, northeastern Iran. A total of 42,403 men and women participated in the study and completed a diet questionnaire at enrollment. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals. We documented 3,291 deaths (1,467 from CVD and 859 from cancer) during 11 years of follow-up (2004-2015)...
April 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28361446/does-milk-intake-promote-prostate-cancer-initiation-or-progression-via-effects-on-insulin-like-growth-factors-igfs-a-systematic-review-and-meta-analysis
#11
REVIEW
Sean Harrison, Rosie Lennon, Jeff Holly, Julian P T Higgins, Mike Gardner, Claire Perks, Tom Gaunt, Vanessa Tan, Cath Borwick, Pauline Emmet, Mona Jeffreys, Kate Northstone, Sabina Rinaldi, Stephen Thomas, Suzanne D Turner, Anna Pease, Vicky Vilenchick, Richard M Martin, Sarah J Lewis
PURPOSE: To establish whether the association between milk intake and prostate cancer operates via the insulin-like growth factor (IGF) pathway (including IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3). METHODS: Systematic review, collating data from all relevant studies examining associations of milk with IGF, and those examining associations of IGF with prostate cancer risk and progression. Data were extracted from experimental and observational studies conducted in either humans or animals, and analyzed using meta-analysis where possible, with summary data presented otherwise...
June 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28349283/infectious-agents-in-bovine-red-meat-and-milk-and-their-potential-role-in-cancer-and-other-chronic-diseases
#12
Harald Zur Hausen, Timo Bund, Ethel-Michele de Villiers
Red meat and dairy products have frequently been suggested to represent risk factors for certain cancers, chronic neurodegenerative diseases, and autoimmune and cardiovascular disorders. This review summarizes the evidence and investigates the possible involvement of infectious factors in these diseases. The isolation of small circular single-stranded DNA molecules from serum and dairy products of Eurasian Aurochs (Bos taurus)-derived cattle, obviously persisting as episomes in infected cells, provides the basis for further investigations...
March 28, 2017: Current Topics in Microbiology and Immunology
https://www.readbyqxmd.com/read/28347154/-circulating-micrornas-in-the-diagnostics-of-endocrine-neoplasms
#13
Ábel Decmann, Pál Perge, Zoltán Nagy, Henriett Butz, Attila Patócs, Péter Igaz
MicroRNAs (miRNA, miR) are short - 19-25 nucleotide long - single stranded (in their mature form), non-coding RNA molecules that regulate gene expression mostly at the posttranscriptional level. microRNAs are involved in the regulation of various physiological processes such as cell differentiation and proliferation, development, haematopoesis, cell death, while their aberrant expression is observed in numerous diseases, like autoimmune disorders, inflammations, vascular diseases or tumorigenesis. microRNAs are expressed in a tissue specific fashion...
April 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28344572/gut-colonization-by-methanogenic-archaea-is-associated-with-organic-dairy-consumption-in-children
#14
Jeroen A A van de Pol, Niels van Best, Catherine A Mbakwa, Carel Thijs, Paul H Savelkoul, Ilja C W Arts, Mathias W Hornef, Monique Mommers, John Penders
The gut microbiota represents a complex and diverse ecosystem with a profound impact on human health, promoting immune maturation, and host metabolism as well as colonization resistance. Important members that have often been disregarded are the methanogenic archaea. Methanogenic archaea reduce hydrogen levels via the production of methane, thereby stimulating food fermentation by saccharolytic bacteria. On the other hand, colonization by archaea has been suggested to promote a number of gastrointestinal and metabolic diseases such as colorectal cancer, inflammatory bowel disease, and obesity...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28342603/invited-review-the-anti-inflammatory-properties-of-dairy-lipids
#15
R Lordan, I Zabetakis
Dairy product consumption is often associated with negative effects because of its naturally high levels of saturated fatty acids. However, recent research has shown that dairy lipids possess putative bioactivity against chronic inflammation. Inflammation triggers the onset of several chronic diseases, including cardiovascular disease, type 2 diabetes mellitus, obesity, and cancer. This review discusses the anti-inflammatory properties of dairy lipids found in milk, yogurt, and cheese, and it examines them in relation to their implications for human health: their protective effects and their role in pathology...
March 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28326003/effects-of-organic-food-consumption-on-human-health-the-jury-is-still-out
#16
Marcin Barański, Leonidas Rempelos, Per Ole Iversen, Carlo Leifert
The most recent systematic literature reviews and meta-analyses have indicated significant and nutritionally-relevant composition differences between organic and conventional foods. This included higher antioxidant, but lower cadmium and pesticide levels in organic crops, and higher omega-3 fatty acids concentrations in organic meat and dairy products. Also, results from a small number of human cohort studies indicate that there are positive associations between organic food consumption and reduced risk/incidence of certain acute diseases (e...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28288429/human-health-risk-assessment-of-ddts-and-hchs-through-dietary-exposure-in-nanjing-china
#17
Qianqian Zhang, Zhonghuan Xia, Minmin Wu, Liping Wang, Hao Yang
In a market based study in Nanjing, a typical southeast city in China, the most common consumed 23 kinds of foods from eleven different categories (vegetable, fruit, fish, pork, livestock meat, chicken, egg, milk, oil, rice and flour) were sampled in November 2015. The concentrations of DDTs and HCHs in foods were analyzed using gas chromatography with mass spectrometer detector. The residual amounts of DDTs and HCHs in foods were 0.95-3.53 ng g(-1) and 0.32-1.96 ng g(-1), respectively. The highest residual of ∑10OCPs was 4...
March 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28279179/the-effect-of-bowel-preparation-regime-on-interfraction-rectal-filling-variation-during-image-guided-radiotherapy-for-prostate-cancer
#18
Ali Hosni, Tara Rosewall, Timothy Craig, Vickie Kong, Andrew Bayley, Alejandro Berlin, Robert Bristow, Charles Catton, Padraig Warde, Peter Chung
BACKGROUND: This study aimed to investigate the tolerability and impact of milk of magnesia (MoM) on interfraction rectal filling during prostate cancer radiotherapy. METHODS: Two groups were retrospectively identified, each consisting of 40 patients with prostate cancer treated with radiotherapy to prostate+/-seminal vesicles, with daily image-guidance in 78Gy/39fractions/8 weeks. The first-group followed anti-flatulence diet with MoM started 3-days prior to planning-CT and continued during radiotherapy, while the second-group followed the same anti-flatulence diet only...
March 9, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28278079/breast-carcinoma-associated-with-prolactinoma-a-case-report
#19
Yurong Zheng, Wenju Mo, Yang Yu, Dehong Zou, Xiangming He, Xianghou Xia, Jiejie Hu
We report a 28-year-old woman who presented with a 6-year history of milk-like discharge from both of her nipples and was diagnosed with prolactinoma based on computed tomography (CT) findings and serum prolactin level. Further breast examination revealed a mass located in the upper outer region of the left breast. She underwent subtotal pituitary tumor resection. Thereafter, modified radical mastectomy was performed for left breast cancer. Twelve years after treatment, prolactinoma recurrence was detected, and bromocriptine therapy was administered...
March 4, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28243404/effect-of-persian-medicine-remedy-on-chemotherapy-induced-nausea-and-vomiting-in-breast-cancer-a-double-blind-randomized-crossover-clinical-trial
#20
Mohammad Nazari, Ali Taghizadeh, Mojtaba Mousavi Bazzaz, Hassan Rakhshandeh, Sadegh Shokri
BACKGROUND: Chemotherapy induced nausea and vomiting (CINV) is a side effect, and has negative effect on quality of life and continuation of chemotherapy. Despite new regimen and drugs, the problems still remain and standard guidelines, effective treatment and supportive care for refractory CINV are still not yet established. Persian medicine, the old Iranian medical school, offer Persumac (prepared from Rhus Coriaria and Bunium Persicum Boiss). OBJECTIVE: The specific objectives were to assess the effect of Persumac on the number and severity of nausea and vomiting in refractory CINV in acute and delayed phase...
January 2017: Electronic Physician
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