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https://www.readbyqxmd.com/read/29782854/combined-treatment-with-sorafenib-and-silibinin-synergistically-targets-both-hcc-cells-and-cancer-stem-cells-by-enhanced-inhibition-of-the-phosphorylation-of-stat3-erk-akt
#1
Jie Mao, Hongbao Yang, Tingting Cui, Pan Pan, Nadia Kabir, Duo Chen, Jinyan Ma, Xingyi Chen, Yijun Chen, Yong Yang
Silibinin, a nontoxic bioactive component in milk thistle, is used as a liver-protective drug in the clinic mainly because of its antioxidant and anti-inflammation activities. In this study, we studied the cytotoxic effects of silibinin combined with sorafenib on hepatocellular carcinoma (HCC). The results indicated that silibinin combined with sorafenib potently inhibited the proliferation of various HCC cells and induced significant apoptosis. In an HCC subcutaneous transplantation tumor model, the combination of silibinin and sorafenib significantly suppressed tumor growth compared with monotherapy...
May 18, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29781734/dairy-consumption-and-risk-of-testicular-cancer-a-systematic-review
#2
Virginia Signal, Stephanie Huang, Diana Sarfati, James Stanley, Katherine A McGlynn, Jason K Gurney
Dairy consumption has been studied extensively in terms of its relationship with testicular cancer (TC), yet this relationship remains unclear. In this systematic review, we aimed to answer whether TC development is associated with (a) high amounts of dairy product consumption, (b) the type of dairy product consumed, (c) increasing levels of dairy product consumption, and (d) dairy consumption during certain periods during the lifecourse. Following a systematic review of the literature, eight studies (all case-control studies) were included in our review...
May 21, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29770759/milk-and-risk-of-colorectal-colon-and-rectal-cancer-in-the-norwegian-women-and-cancer-nowac-cohort-study
#3
Toril Bakken, Tonje Braaten, Anja Olsen, Anette Hjartåker, Eiliv Lund, Guri Skeie
According to World Cancer Research Fund International/American Institute for Cancer Research, it is 'probable' that dairy products decrease the risk of colorectal cancer (CRC). However, meta-analyses restricted to women have not shown associations between milk intake and risk of CRC. The aim of this study was to examine the association between milk intake and risk of CRC, colon cancer and rectal cancer among women. Data from 81 675 participants in the Norwegian Women and Cancer Cohort Study were included, and multivariable Cox proportional hazard regression models were used to investigate milk intake using two different analytical approaches: one that included repeated measurements and one that included baseline measurements only (872 and 1084 CRC cases, respectively)...
June 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29764340/in-vitro-and-in-vivo-anti-cancer-activity-of-silymarin-on-oral-cancer
#4
Dong-Hoon Won, Lee-Han Kim, Boonsil Jang, In-Hyoung Yang, Hye-Jeong Kwon, Bohwan Jin, Seung Hyun Oh, Ju-Hee Kang, Seong-Doo Hong, Ji-Ae Shin, Sung-Dae Cho
Silymarin, a standardized extract from milk thistle fruits has been found to exhibit anti-cancer effects against various cancers. Here, we explored the anti-cancer activity of silymarin and its molecular target in human oral cancer in vitro and in vivo. Silymarin dose-dependently inhibited the proliferation of HSC-4 oral cancer cells and promoted caspase-dependent apoptosis. A human apoptosis protein array kit showed that death receptor 5 may be involved in silymarin-induced apoptosis, which was also shown through western blotting, immunocytochemistry, and reverse transcription-polymerase chain reaction...
May 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29762617/anticancer-potential-against-cervix-cancer-hela-cell-line-of-probiotic-lactobacillus-casei-and-lactobacillus-paracasei-strains-isolated-from-human-breast-milk
#5
Muhammad Shahid Riaz Rajoka, Haobin Zhao, Yao Lu, Ziyang Lian, Na Li, Nazim Hussain, Dongyan Shao, Mingliang Jin, Qi Li, Junling Shi
Lactic acid bacteria have been categorized as probiotics and play a crucial role in human health by stimulating the supply of nutrients, shaping the immune system, and preventing the colonization of pathogenic microbes. This study investigated the mechanisms for the action of three potential probiotic Lactobacillus strains: Lactobacillus casei SR1, Lactobacillus casei SR2, and Lactobacillus paracasei SR4 isolated from human breast milk. These Lactobacillus strains were identified via 16S DNA sequencing and characterized via biochemical assays including acid resistance, bile resistance, antioxidant activity, and antibiotic susceptibility...
May 15, 2018: Food & Function
https://www.readbyqxmd.com/read/29756573/lactoferrin-major-physiological-functions-and-applications
#6
Liyuan Hao, Qiang Shan, Jingya Wei, Fengtao Ma, Peng Sun
Lactoferrin (lactotransferrin; Lf) is an iron-binding glycoprotein and one of the most important bioactivators in milk and other external secretions. It has numerous biological roles, including the regulation of iron absorption and modulation of immune responses, and has anti-microbial, anti-viral, antioxidant, anti-cancer, and anti-inflammatory activities. Lf regulates the quantity of iron absorbed in the intestine via its role in iron transport and can also chelate iron, directly or indirectly. Notably, it has been used as an adjuvant therapy for some intestinal diseases...
May 14, 2018: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/29756217/comparative-two-dimensional-polyacrylamide-gel-electrophoresis-2d-page-of-human-milk-to-identify-dysregulated-proteins-in-breast-cancer
#7
Roshanak Aslebagh, Devika Channaveerappa, Kathleen F Arcaro, Costel C Darie
Breast Cancer (BC) remains a major cause of mortality, and early detection is considered important for reducing BC-associated deaths. Early detection of BC is challenging in young women, due to the limitations of mammography on the dense breast tissue of young women. We recently reported results of a pilot proteomics study, using one-dimensional polyacrylamide gel electrophoresis (1D-PAGE) and mass spectrometry (MS) to investigate differences in milk proteins from women with and without BC. Here, we applied two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and MS to compare the protein pattern in milk from the breasts of a single woman who was diagnosed with BC in one breast 24 months after donating her milk...
May 13, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29742063/intake-of-fruit-vegetables-and-milk-products-and-correlates-among-school-boys-in-saudi-arabia
#8
Ali Saad R Alsubaie
Background Healthy dietary behaviors have a significant impact on children's health and development. Diets high in fruit and vegetables demonstrate a strong and consistent pattern for decreasing the risk of and providing benefits against cardiovascular disease, diabetes, obesity and many cancers. Yet, little is known about the pattern of fruit, vegetables and dairy products consumption among children in Saudi Arabia. Objectives The aim of this study was to investigate the consumption of fruit, vegetables and milk products and their dietary correlates among school boys in Saudi Arabia...
May 9, 2018: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29737161/anti-cancer-and-anti-migration-effects-of-combinatorial-treatment-with-5-fluorouracil-and-lactobacillus-paracasei-subsp-paracasei-ntu-101-fermented-skim-milk-extracts-on-colorectal-cancer-cells
#9
Chia-Yuan Chang, Tzu-Ming Pan
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Metabolites of lactic acid bacteria (LAB) have anti-cancer and anti-metastasis capacity. This study aimed to investigate the chemotherapeutic combination effect of Lactobacillus paracasei subsp. paracasei NTU 101-fermented skim milk (NTU101-FM) extracts and the chemotherapeutic drug 5-fluorouracil (5-FU) in a cellular CRC model. NTU101-FM extracts effectively reduced CRC cell viability but was not cytotoxic to colon epithelial cells. Moreover, they increased RAW 264...
May 8, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29735098/determination-of-isothiocyanate-protein-conjugates-in-milk-and-curd-after-adding-garden-cress-lepidium-sativum-l
#10
Carla Kühn, Tobias von Oesen, Franziska S Hanschen, Sascha Rohn
Isothiocyanates (ITC) play an important role in health promotion and cancer prevention due to their anti-bacterial, anti-inflammatory, and anti-cancerogenic properties. However, ITC are highly reactive so that a reaction with further food components is very likely. For example, a reaction of ITC with nucleophilic amino acid side chains of proteins such as cysteine and lysine can occur, reducing the bioavailability of indispensable amino acids and protein functions may be altered. Therefore, it is of great interest to investigate the fate of ITC in the food matrix...
June 2018: Food Research International
https://www.readbyqxmd.com/read/29735091/development-of-a-cryptosporidium-arsenic-multi-risk-assessment-model-for-infant-formula-prepared-with-tap-water-in-france
#11
G Boué, L A Wasiewska, E Cummins, J-P Antignac, B Le Bizec, S Guillou, J-M Membré
Tap water is used in France to reconstitute powder infant formula, although it is not sterile and possibly contaminated by microbiological and chemical hazards. The present study aims to quantify risks of using tap water in France for the preparation of infant formula, during the first six months of life. Cryptosporidium and arsenic were selected as hazards of greatest concern in microbiology and chemistry, respectively. A probabilistic model was developed using French (when available) and European (alternatively) data...
June 2018: Food Research International
https://www.readbyqxmd.com/read/29730848/microrna-216b-inhibits-heat-stress-induced-cell-apoptosis-by-targeting-fas-in-bovine-mammary-epithelial-cells
#12
Mingcheng Cai, Yongsong Hu, Tianhao Zheng, Hongbing He, Wudian Xiao, Buwei Liu, Yu Shi, Xianbo Jia, Shiyi Chen, Jie Wang, Songjia Lai
Heat stress affects milk yield and quality in lactating dairy cows in summer. Bovine mammary epithelial cells (bMECs) play a key role in milk secretion, and microRNAs (miRNAs) regulate numerous functions of bMEC. Previous reports have verified that miR-216b regulated cell apoptosis through repressing target genes in several cancer cells. So, our purpose was to explore the potential involvement of miR-216b in heat stress-induced cell apoptosis in bMECs. Firstly, the heat stress model was constructed and we found that apoptotic rates of bMECs significantly increased under heat stress...
May 5, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29722851/calcium-magnesium-and-whole-milk-intakes-and-high-aggressive-prostate-cancer-in-the-north-carolina-louisiana-prostate-cancer-project-pcap
#13
Susan E Steck, Omonefe O Omofuma, L Joseph Su, Amanda A Maise, Anna Woloszynska-Read, Candace S Johnson, Hongmei Zhang, Jeannette T Bensen, Elizabeth T H Fontham, James L Mohler, Lenore Arab
Background: Calcium and dairy product intakes have been positively associated with prostate cancer risk. An imbalance in concentrations of calcium and magnesium has been associated with multiple chronic diseases, although few studies have examined the relation with prostate cancer aggressiveness. Objective: The goal of this study was to examine the association between dietary intakes of calcium and magnesium, the calcium-to-magnesium ratio (Ca:Mg), and dairy products and prostate cancer aggressiveness...
May 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29707666/detection-of-ochratoxin-a-in-human-breast-milk-in-jiroft-city-south-of-iran
#14
Ali Kamali, Sareh Mehni, Mohadeseh Kamali, Mehdi Taheri Sarvtin
Background and Purpose: Breastfeeding plays an important role in the growth and development of infants. However, breast milk may be contaminated with various mycotoxins. Ochratoxin A is one of the most important mycotoxins with nephrotoxic, carcinogenic, teratogenic, genotoxic, and immunotoxic properties. Thus, we carried out this study to determine the concentration of ochratoxin A in human breast milk in Jiroft, Kerman Province, south of Iran. Materials and Methods: Eighty-four human breast milk samples were collected from mothers visiting the number one clinic in Jiroft city...
September 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29703390/concurrent-administration-of-anticancer-chemotherapy-drug-and-herbal-medicine-on-the-perspective-of-pharmacokinetics
#15
REVIEW
Yung-Yi Cheng, Chen-Hsi Hsieh, Tung-Hu Tsai
With an increasing number of cancer patients seeking an improved quality of life, complementary and alternative therapies are becoming more common ways to achieve such improvements. The potential risks of concurrent administration are serious and must be addressed. However, comprehensive evidence for the risks and benefits of combining anticancer drugs with traditional herbs is rare. Pharmacokinetic investigations are an efficient way to understand the influence of concomitant remedies. Therefore, this study aimed to collect the results of pharmacokinetic studies relating to the concurrent use of cancer chemotherapy and complementary and alternative therapies...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29702680/the-economic-burden-of-not-meeting-food-recommendations-in-canada-the-cost-of-doing-nothing
#16
Jessica R L Lieffers, John Paul Ekwaru, Arto Ohinmaa, Paul J Veugelers
Few studies have estimated the economic burden of chronic diseases (e.g., type 2 diabetes, cardiovascular diseases, cancers) attributable to unhealthy eating. In this study, we estimated the economic burden of chronic disease attributable to not meeting Canadian food recommendations. We first obtained chronic disease risk estimates for intakes of both protective (1. vegetables; 2. fruit; 3. whole grains; 4. milk; 5. nuts and seeds) and harmful (6. processed meat; 7. red meat; 8. sugar-sweetened beverages) foods from the Global Burden of Disease Study, and food intakes from the 2004 Canadian Community Health Survey 24-hour dietary recalls (n = 33,932 respondents)...
2018: PloS One
https://www.readbyqxmd.com/read/29698706/the-effect-of-size-and-polymer-architecture-of-doxorubicin-poly-ethylene-glycol-conjugate-nanocarriers-on-breast-duct-retention-potency-and-toxicity
#17
Zichao Gu, Dayuan Gao, Firas Al-Zubaydi, Shike Li, Yashveer Singh, Kristia Rivera, Jennifer Holloway, Zoltan Szekely, Susan Love, Patrick J Sinko
Although systemic administration of chemotherapeutic agents is routinely used for treating invasive breast cancer, the only therapeutic options for ductal carcinoma in situ (DCIS) are surgery and radiation. Treating DCIS by delivering drugs locally to the affected milk duct offers significant advantages over systemic administration, including reduced systemic and breast toxicities, as well as a greatly reduced need for surgery and radiation. In this study, mammary gland retention and toxicity of intraductally administered poly(ethylene) glycol-doxorubicin (PEG-DOX) polymeric conjugate nanocarriers of varying molecular sizes and architectures were investigated...
April 23, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29691472/production-and-delivery-of-helicobacter-pylori-napa-in-lactococcus-lactis-and-its-protective-efficacy-and-immune-modulatory-activity
#18
Xiaoyan Peng, Rongguang Zhang, Guangcai Duan, Chen Wang, Nan Sun, Linghan Zhang, Shuaiyin Chen, Qingtang Fan, Yuanlin Xi
Helicobacter pylori neutrophil-activating protein A subunit (NapA) has been identified as a virulence factor, a protective antigen and a potent immunomodulator. NapA shows unique application potentials for anti-H. pylori vaccines and treatment strategies of certain allergic diseases and carcinomas. However, appropriate production and utilization modes of NapA still remain uncertain to date. This work has established a novel efficient production and utilization mode of NapA by using L. lactis as an expression host and delivery vector, and demonstrated immune protective efficacy and immune modulatory activity of the engineered L...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669808/lactoferrin-is-a-natural-inhibitor-of-plasminogen-activation
#19
Alexander Zwirzitz, Michael Reiter, Rostislav Skrabana, Anna Ohradanova-Repic, Otto Majdic, Marianna Gutekova, Ondrej Cehlar, Eva Petrovčíková, Eva Kutejova, Gerold Stanek, Hannes Stockinger, Vladimir Leksa
The plasminogen system is essential for dissolution of fibrin clots, and in addition, it is involved in a wide variety of other physiological processes, including proteolytic activation of growth factors, cell migration, and removal of protein aggregates. On the other hand, uncontrolled plasminogen activation contributes to many pathological processes, e.g. tumor cells' invasion in cancer progression. Moreover, some virulent bacterial species, e.g. Streptococci or Borrelia, bind human plasminogen and hijack the host's plasminogen system to penetrate tissue barriers...
April 18, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29667662/camel-milk-attenuates-methotrexate-induced-kidney-injury-via-activation-of-pi3k-akt-enos-signaling-and-intervention-with-oxidative-aberrations
#20
Hany H Arab, Samir A Salama, Ibrahim A Maghrabi
Methotrexate (MTX) is a classical chemotherapeutic agent with nephrotoxicity as the most disturbing adverse effect. So far, its underlying molecular mechanisms, particularly PI3K/Akt/eNOS transduction, are inadequately explored. Several antioxidant modalities have been characterized to ameliorate MTX-induced renal injury. In this regard, Camel milk (CM) is a natural product with recognized antioxidant and anti-inflammatory features. Thus, the current study aimed to investigate the potential ameliorating effects of CM in MTX-induced kidney injury in rats...
April 18, 2018: Food & Function
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