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https://www.readbyqxmd.com/read/29152146/breast-tissue-oral-and-urinary-microbiomes-in-breast-cancer
#1
Hannah Wang, Jessica Altemus, Farshad Niazi, Holly Green, Benjamin C Calhoun, Charles Sturgis, Stephen R Grobmyer, Charis Eng
It has long been proposed that the gut microbiome contributes to breast carcinogenesis by modifying systemic estrogen levels. This is often cited as a possible mechanism linking breast cancer and high-fat, low-fiber diets as well as antibiotic exposure, associations previously identified in population-based studies. More recently, a distinct microbiome has been identified within breast milk and tissue, but few studies have characterized differences in the breast tissue microbiota of patients with and without cancer, and none have investigated distant body-site microbiomes outside of the gut...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29142587/factors-associated-with-the-high-prevalence-of-oesophageal-cancer-in-western-kenya-a-review
#2
REVIEW
Gabriel Kigen, Naftali Busakhala, Zipporah Kamuren, Hillary Rono, Wilfred Kimalat, Evangeline Njiru
Oesophageal carcinoma (OC) is highly prevalent in Western Kenya especially among the members of the Kalenjin community who reside in the Northern and Southern areas of the Rift Valley. Previous authors have suggested potential association of environmental and genetic risk factors with this high prevalence. The environmental factors that have been suggested include contamination of food by mycotoxins and/or pesticides, consumption of traditional alcohol (locally referred to "Busaa" and "Chan'gaa"), use of fermented milk ("Mursik"), poor diet, tobacco use and genetic predisposition...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29129231/the-association-between-the-index-of-nutritional-quality-inq-and-breast-cancer-and-the-evaluation-of-nutrient-intake-of-breast-cancer-patients-a-case-control-study
#3
Farhad Vahid, Mahshid Hatami, Mahya Sadeghi, Fatemeh Ameri, Zeinab Faghfoori, Sayed Hossein Davoodi
OBJECTIVE: Breast cancer (BrCa) is the most frequently diagnosed cancer among females and second cancer after lung cancer in many societies. In Iran, the risk for BrCa is 1 in 35 and each year, 8000 new patients have been diagnosed with BrCa. Studies have shown that dietary components are implicated in the etiology of BrCa. The Index of Nutritional Quality (INQ) is a method of quantitative and qualitative analysis of single foods, meals, and diets. The aim of this study was to determine the usefulness of INQs in predicting BrCa risk...
January 2018: Nutrition
https://www.readbyqxmd.com/read/29125314/associations-of-calcium-and-dairy-products-with-all-cause-and-cause-specific-mortality-in-the-reasons-for-geographic-and-racial-differences-in-stroke-regards-prospective-cohort-study
#4
Caroline Y Um, Suzanne E Judd, W Dana Flanders, Veronika Fedirko, Roberd M Bostick
Associations of calcium and dairy product intakes with cardiovascular disease risk and cancer mortality are controversial. We investigated associations of calcium and dairy product intakes with mortality in the prospective REasons for Geographic and Racial Differences in Stroke study (n = 30,239). Of 2,966 total deaths, 32.3% were from CVD and 28.8% from cancer. For those in the upper relative to the lowest quintile of intakes, from Cox proportional hazards regression models, the multivariable-adjusted hazard ratios (HRs) for all-cause mortality were 1...
November 10, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29121648/correction-dignity-and-distress-towards-the-end-of-life-across-four-non-cancer-populations
#5
Harvey Max Chochinov, Wendy Johnston, Susan E McClement, Thomas F Hack, Brenden Dufault, Murray Enns, Genevieve Thompson, Mike Harlos, Ronald W Damant, Clare D Ramsey, Sara Davison, James Zacharias, Doris Milke, David Strang, Heather J Campbell-Enns, Maia S Kredentsere
[This corrects the article DOI: 10.1371/journal.pone.0147607.].
2017: PloS One
https://www.readbyqxmd.com/read/29114378/imminent-angiotensin-converting-enzyme-inhibitor-from-microbial-source-for-cancer-therapy
#6
Lida Ebrahimi, Jafar Ai, Aliakbar Alizadeh, Mehrdad Shariaty
Background: Drugs targeting Angiotensin I-converting enzyme (ACE) have been used broadly in cancer chemotherapy. The recent past coupled with our results demonstrates the effective use of ACE inhibitors (ACEi) as anticancer agents, and they are potentially relevant in deriving new inhibitors. Methods: Bacterial strains were isolated from cow milk collected in Coimbatore, Tamil Nadu, India and plated on nutrient agar medium. The identity of the strain was ascertained by 16s rRNA gene sequencing method and was submitted to the NCBI GenBank nucleotide database...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29105845/milk-and-other-dairy-foods-in-relation-to-prostate-cancer-recurrence-data-from-the-cancer-of-the-prostate-strategic-urologic-research-endeavor-capsure%C3%A2
#7
David Tat, Stacey A Kenfield, Janet E Cowan, Jeanette M Broering, Peter R Carroll, Erin L Van Blarigan, June M Chan
BACKGROUND: High-fat dairy, particularly whole milk, in healthy men may increase risk of aggressive prostate cancer. However, data are limited regarding dairy after prostate cancer diagnosis. METHOD: We conducted a prospective study among 1334 men with non-metastatic prostate cancer in the Cancer of the Prostate Strategic Urologic Research Endeavor. Men answered a food frequency questionnaire in 2004-2005 (median 2 years after diagnosis) and were followed until 2016 for recurrence, defined as: prostate cancer death, bone metastases, biochemical recurrence, or secondary treatment...
November 6, 2017: Prostate
https://www.readbyqxmd.com/read/29079186/investigating-the-association-between-african-spontaneously-fermented-dairy-products-faecal-carriage-of-streptococcus-infantarius-subsp-infantarius-and-colorectal-adenocarcinoma-in-kenya
#8
Dasel W M Kaindi, Wambui Kogi-Makau, Godfrey N Lule, Bernd Kreikemeyer, Pierre Renault, Bassirou Bonfoh, Esther Schelling, Jakob Zinsstag, Christophe Lacroix, Leo Meile, Christoph Jans, Jan Hattendorf
Consumption of traditional fermented dairy products (tFDP) in Africa leads to the ingestion of up to 10(8)Streptococcus infantarius subspecies infantarius (Sii) per millilitre of spontaneously fermented milk. Sii is a member of the Streptococcus bovis/Streptococcus equinus complex (SBSEC) for which some members are associated particularly with colorectal cancer or endocarditis. The extent of health risks to tFDP consumers is largely unknown. A hospital-based unmatched case-control study was conducted at Kenyatta National Hospital, Nairobi (Kenya) on 80 cases and 193 controls that were selected exhaustively from patients attending colonoscopy at the hospital...
October 25, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29074485/animal-models-of-chemotherapy-induced-mucositis-translational-relevance-and-challenges
#9
Per T Sangild, René Liang Shen, Peter Erik Lotko Pontoppidan, Mathias Rathe
Chemotherapy for cancer patients induces damaging tissue reactions along the epithelium of the gastrointestinal tract (GIT). This chemotherapy-induced mucositis (CIM) is a serious side effect of cytotoxic drugs and several animal models of CIM have been developed to help understand the progression of CIM, and how to prevent it. Animal models allow highly controlled experimental conditions, detailed organ (e.g. GIT) insights, standardized, clinically-relevant treatment regimens and discovery of new biomarkers...
October 26, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29071499/lactase-persistence-milk-intake-and-mortality-in-the-danish-general-population-a-mendelian-randomization-study
#10
Helle Kirstine Mørup Bergholdt, Børge Grønne Nordestgaard, Anette Varbo, Christina Ellervik
Meta-analyses have suggested no association between milk intake and mortality. Since only few studies have been conducted, we investigated the association between the lactase persistent genetic variant LCT-13910 C/T (rs4988235), a proxy for long-term low and high intake of milk, and mortality. We used two Danish population-based studies with self-reported intake of milk and genotyping for LCT-13910 C/T. We obtained information on all-cause and cause-specific mortality (cardiovascular and cancer) from the national Danish registries...
October 25, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29068700/silibinin-reduces-the-impact-of-obesity-on-invasive-liver-cancer
#11
C Miethe, H Nix, R Martin, A R Hernandez, R S Price
Obesity is associated with non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Obesity and metabolic abnormalities resulting in low-grade inflammation can increase the risk of developing NASH and HCC. NASH, a risk factor for HCC, is characterized by increased inflammation, lipid accumulation, and liver injury. Obesogenic proteins modulate signaling pathways that induce physiological changes including lipogenesis, ROS, and inflammation. Silibinin, a polyphenol in milk thistle seed, has been shown to have anti-inflammatory properties...
October 25, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29061827/lactoperoxidase-an-antimicrobial-milk-protein-as-a-potential-activator-of-carcinogenic-heterocyclic-amines-in-breast-cancer
#12
Ishfaq Ahmad Sheikh, Essam Hussain Jiffri, Mohammad Amjad Kamal, Ghulam Md Ashraf, Mohd Amin Beg
BACKGROUND: Lactoperoxidase (LPO) is an antimicrobial protein secreted from mammary, salivary and other mucosal glands. It is an important member of heme peroxidase enzymes and the primary peroxidase enzyme present in breast tissues. In addition to the antimicrobial properties, LPO has been shown to be associated with breast cancer etiology. Heterocyclic amines, an important class of environmental and dietary carcinogens, have been increasingly associated with breast cancer etiology. Heterocyclic amines undergo activation in breast tissue as a result of oxidation by LPO...
November 2017: Anticancer Research
https://www.readbyqxmd.com/read/29061807/molecular-interactions-of-carcinogenic-aromatic-amines-4-aminobiphenyl-and-4-4-diaminobiphenyl-with-lactoperoxidase-insight-to-breast-cancer
#13
Ishfaq Ahmad Sheikh, Mohd Amin Beg, Muhammad Yasir
BACKGROUND/AIM: Lactoperoxidase (LPO) is an antimicrobial protein present in milk, saliva, gastric secretions, tears and upper respiratory tract secretions. LPO constitutes an important enzyme of the human immune defense system. However, LPO has also been suggested to be involved in breast cancer etiology through production of reactive free radicals and activation of carcinogenic aromatic compounds. Aromatic compounds are generally highly lipophilic and thus accumulate in highly fatty breast tissues...
November 2017: Anticancer Research
https://www.readbyqxmd.com/read/29047044/exosomes-for-the-enhanced-tissue-bioavailability-and-efficacy-of-curcumin
#14
Farrukh Aqil, Radha Munagala, Jeyaprakash Jeyabalan, Ashish Kumar Agrawal, Ramesh Gupta
Exosomes are extracellular microvesicles with a particle size of 30-100 nm and carry a cargo of proteins, lipids, RNA, and DNA. Their properties of shuttling in-and-out of the cells suggest that these particles can be exploited as a nano drug carrier. In this manuscript, we show that curcumin can be delivered effectively using milk-derived exosomes. Curcumin when mixed with exosomes in the presence of 10% ethanol:acetonitrile (1:1) provided a drug load of 18-24%, and the formulation stored at - 80°C was stable for 6 months as determined by particle size analysis, drug load, and antiproliferative activity...
November 2017: AAPS Journal
https://www.readbyqxmd.com/read/29037495/residuals-of-organophosphate-esters-in-foodstuffs-and-implication-for-human-exposure
#15
Jinjian Ding, Tongqing Deng, Mengmeng Xu, Shen Wang, Fangxing Yang
Foodstuffs may be contaminated by organophosphate esters (OPEs) and become an important source of human exposure since OPEs are ubiquitous in the environment. In the present study, 10 OPEs were analyzed in various food matrices collected from a city in Eastern China including chicken, pork, fishes, vegetables, tofu, eggs, milk and cereals. The concentrations of Σ10OPEs ranged from 1.1 to 9.6 ng g(-1) fresh weight (fw) in the foodstuffs. Cereals had the highest residual level of total OPEs with a mean value of 5...
October 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29032473/oligosaccharide-biotechnology-an-approach-of-prebiotic-revolution-on-the-industry
#16
REVIEW
Mario Cezar Rodrigues Mano, Iramaia Angélica Neri-Numa, Juliana Bueno da Silva, Bruno Nicolau Paulino, Marina Gabriel Pessoa, Gláucia Maria Pastore
Oligosaccharides are polymers with two to ten monosaccharide residues which have sweetener functions and sensory characteristics, in addition to exerting physiological effects on human health. The ones called nondigestible exhibit a prebiotic behavior being fermented by colonic microflora or stimulating the growth of beneficial bacteria, playing roles in the immune system, protecting against cancer, and preventing cardiovascular and metabolic issues. The global prebiotics market is expected to grow around 12...
October 14, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29028087/axillary-ectopic-lobular-carcinoma-of-breast-two-rare-case-reports
#17
A Conversi, M L Meggiorini, P Fino, G Soda, N Scuderi, M G Onesti
OBJECTIVE: The presence of ectopic or supernumerary breast tissue is a rare event, related to a not complete regression of breast tissue along the milk line. Primary ectopic breast cancer of the axilla can create many difficulties in differential diagnosis with subsequent delayed specific treatments. The incidence of ectopic breast tissue is 0.2-6%, and the axilla is the most common site involved. In this tissue, the same physiologic and pathologic changes as seen in ectopic breast tissue may occur, including carcinoma formation...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29026007/milk-fat-components-with-potential-anticancer-activity-a-review
#18
Luis M Rodríguez-Alcalá, M Pilar Castro-Gómez, Lígia L Pimentel, Javier Fontecha
During many years, the milk fat has been unfairly undervalued due to its association with higher levels of cardiovascular diseases, dyslipidaemia or obesity, among others. However, currently, this relationship is being re-evaluated because some of the dairy lipid components have been attributed potential health benefits. Due to this, and based on the increasing incidence of cancer in our society, this review work aims to discuss the state of the art concerning scientific evidences of milk lipid components and reported anticancer properties...
October 12, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28991298/exosomal-delivery-of-berry-anthocyanidins-for-the-management-of-ovarian-cancer
#19
Farrukh Aqil, Jeyaprakash Jeyabalan, Ashish K Agrawal, Al-Hassan Kyakulaga, Radha Munagala, Lynn Parker, Ramesh C Gupta
Despite optimal diagnosis and early therapeutic interventions, the prognosis for ovarian cancer patients remains dismal because the efficacy of chemotherapy is limited by the development of resistance and off-site toxicity. Berry bioactives indicate preventive and therapeutic activities against various cancer types. Here, we examined the antiproliferative activity of berry anthocyanidins (Anthos) against drug-sensitive (A2780) and drug-resistant (A2780/CP70, OVCA432 and OVCA433) ovarian cancer cells. These drug-resistant ovarian cancer cell lines overexpress p-glycoproteins (PgP) and show >100-fold resistance to the chemotherapeutic drug cisplatin compared to A2780...
October 9, 2017: Food & Function
https://www.readbyqxmd.com/read/28990245/effects-of-exposure-to-six-chemical-ultraviolet-filters-commonly-used-in-personal-care-products-on-motility-of-mcf-7-and-mda-mb-231-human-breast-cancer-cells-in-vitro
#20
Maha Alamer, Philippa D Darbre
Benzophenone (BP)-1, BP-2, BP-3, octylmethoxycinnamate (OMC), 4-methylbenzilidenecamphor and homosalate are added to personal care products to absorb ultraviolet light. Their presence in human milk and their oestrogenic activity suggests a potential to influence breast cancer development. As metastatic tumour spread is the main cause of breast cancer mortality, we have investigated the effects of these compounds on migration and invasion of human breast cancer cell lines. Increased motility of oestrogen-responsive MCF-7 human breast cancer cells was observed after long-term exposure (>20 weeks) to each of the six compounds at ≥10(-7)  m concentrations using three independent assay systems (scratch assay, live cell imaging, xCELLigence technology) and increased invasive activity was observed through matrigel using the xCELLigence system...
October 9, 2017: Journal of Applied Toxicology: JAT
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