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https://www.readbyqxmd.com/read/28912895/mass-spectrometry-assisted-gel-based-proteomics-in-cancer-biomarker-discovery-approaches-and-application
#1
REVIEW
Rongrong Huang, Zhongsi Chen, Lei He, Nongyue He, Zhijiang Xi, Zhiyang Li, Yan Deng, Xin Zeng
There is a critical need for the discovery of novel biomarkers for early detection and targeted therapy of cancer, a major cause of deaths worldwide. In this respect, proteomic technologies, such as mass spectrometry (MS), enable the identification of pathologically significant proteins in various types of samples. MS is capable of high-throughput profiling of complex biological samples including blood, tissues, urine, milk, and cells. MS-assisted proteomics has contributed to the development of cancer biomarkers that may form the foundation for new clinical tests...
2017: Theranostics
https://www.readbyqxmd.com/read/28900345/alternative-ketogenic-diet-with-coconut-milk-in-a-case-with-underlying-colorectal-cancer
#2
Kamon Chaiyasit, Kanin Tripipitsiriwat, Kusuma Srikaew, Viroj Wiwanitkit
No abstract text is available yet for this article.
April 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28894420/exosomes-as-potential-biomarkers-and-targeted-therapy-in-colorectal-cancer-a-mini-review
#3
REVIEW
Kha Wai Hon, Nadiah Abu, Nurul-Syakima Ab Mutalib, Rahman Jamal
The number of colorectal cancer (CRC) cases have increased gradually year by year. In fact, CRC is one of the most widely diagnosed cancer in men and women today. This disease is usually diagnosed at a later stage of the development, and by then, the chance of survival has declined significantly. Even though substantial progress has been made in understanding the basic molecular mechanism of CRC, there is still a lack of understanding in using the available information for diagnosing CRC effectively. Liquid biopsies are minimally invasive and have become the epitome of a good screening source for stage-specific diagnosis, measuring drug response and severity of the disease...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28879447/lactic-acid-bacteria-isolated-from-yak-milk-show-probiotic-potential
#4
Manpreet Kaur, Harjodh Singh, Manoj Jangra, Lakhwinder Kaur, Pallavi Jaswal, Chetna Dureja, Hemraj Nandanwar, Saumya Ray Chaudhuri, Manoj Raje, Sunita Mishra, Anil Kumar Pinnaka
Probiotic industries strive for new, efficient and promising probiotic strains that impart a positive impact on consumer health. Challenges are persisting in isolation, screening, and selection of the new indigenous probiotic strains. In the present research, we explored the probiotic potential of 17 lactic acid bacteria isolated from Yak milk in a series of in vitro tests. We also demonstrated their health benefits, i.e., cholesterol degradation, lactose digestion, antimicrobial activity, antioxidant, and anticancer activities...
September 6, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28834173/conserved-and-variable-understanding-mammary-stem-cells-across-species
#5
REVIEW
Gat Rauner, Melissa M Ledet, Gerlinde R Van de Walle
Postnatal mammary gland development requires the presence of mammary stem and progenitor cells (MaSC), which give rise to functional milk-secreting cells and regenerate the mammary epithelium with each cycle of lactation. These long-lived, tissue-resident MaSC are also targets for malignant transformation and may be cancer cells-of-origin. Consequently, MaSC are extensively researched in relation to their role and function in development, tissue regeneration, lactation, and breast cancer. The basic structure and function of the mammary gland are conserved among all mammalian species, from the most primitive to the most evolved...
August 22, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28833502/tumor-derived-exosomes-potential-biomarker-or-therapeutic-target-in-breast-cancer
#6
AmirReza Hesari, Seyed Ali Golrokh Moghadam, AmirShayan Siasi, Mahsa Rahmani, Negin Behboodi, Azam Rastgar-Moghadam, Gordon A Ferns, Faezeh Ghasemi, Amir Avan
Exosomes are released by normal and tumour cells, including those involved in breast cancer, and provide a means of intercellular communications. Exosomes with diameters ranging between 30-150 nm are involved in transferring biological information, via various lipids, proteins, different forms of RNAs, and DNA from one cell to another, and this can result in reprogramming of recipient cell functions. These vesicles are present in all body fluids, e.g., blood plasma/serum, semen, saliva, cerebrospinal fluid, breast milk, and urine...
August 18, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28830081/exposure-to-farm-animals-and-risk-of-lung-cancer-in-the-agrican-cohort
#7
Séverine Tual, Clémentine Lemarchand, Mathilde Boulanger, Jean-Charles Dalphin, Bernard Rachet, Elisabeth Marcotullio, Michel Velten, Anne-Valérie Guizard, Bénédicte Clin, Isabelle Baldi, Pierre Lebailly
Epidemiologic studies have found lower risks of lung cancer in farmers. However, little is known about the types of agricultural activities concerned. In the Agriculture and Cancer cohort, we assessed the relationship between animal farming and lung cancer by investigating the types of animals, tasks, and timing of exposure. Analyses included 170,834 participants from the Agriculture and Cancer (AGRICAN) cohort in France. Incident lung cancers were identified through linkage with cancer registries from enrollment (2005-2007) to 2011...
August 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28814964/milk-disrupts-p53-and-dnmt1-the-guardians-of-the-genome-implications-for-acne-vulgaris-and-prostate-cancer
#8
Bodo C Melnik
There is accumulating evidence that milk shapes the postnatal metabolic environment of the newborn infant. Based on translational research, this perspective article provides a novel mechanistic link between milk intake and milk miRNA-regulated gene expression of the transcription factor p53 and DNA methyltransferase 1 (DNMT1), two guardians of the human genome, that control transcriptional activity, cell survival, and apoptosis. Major miRNAs of milk, especially miRNA-125b, directly target TP53 and complex p53-dependent gene regulatory networks...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28806666/doxorubicin-loaded-environmentally-friendly-carbon-dots-as-a-novel-drug-delivery-system-for-nucleus-targeted-cancer-therapy
#9
Yifang Yuan, Bin Guo, Liying Hao, Na Liu, Yunfeng Lin, Wushuang Guo, Xiaoguang Li, Bin Gu
Chemotherapy is widely applied against various kinds of carcinoma. Generally, chemotherapeutic agents, such as Doxorubicin (DOX), Paclitaxel (PTX), 5-Fluorouracil (5-FU), Methotrexate (MTX), and Vinblastine (VLB) are combined with a view to maximizing their efficacy. Unfortunately, chemotherapeutics are indiscriminate and also kill normal healthy cells, resulting in serious side effects. This non-productive and destructive distribution of chemotherapeutics is regarded as one of the largest problems associated with chemotherapy...
July 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28791405/silibinin-suppresses-bladder-cancer-cell-malignancy-and-chemoresistance-in-an-nf-%C3%AE%C2%BAb-signal-dependent-and-signal-independent-manner
#10
Yi Sun, Zhenfeng Guan, Wencai Zhao, Yazhuo Jiang, Qing Li, Yongyi Cheng, Yonggang Xu
Because bladder cancer (BCa) is the 9th most common malignant tumor and 13th leading cause of death due to cancer, therapeutic approaches have attracted a great deal of attention from both clinicians and BCa patients. Although the development of surgery and targeted drugs has brought new challenges for the traditional concept of BCa therapy, various types of chemotherapy remain the final treatment method for many BCa patients. However, chemoresistance inevitably appears, leading to the failure of chemotherapy...
August 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28780347/nanoscale-observation-of-the-natural-structure-of-milk-fat-globules-and-casein-micelles-in-the-liquid-condition-using-a-scanning-electron-assisted-dielectric-microscopy
#11
Toshihiko Ogura, Tomoko Okada
Recently, aqueous nanoparticles have been used in drug-delivery systems for new type medicines. In particular, milk-casein micelles have been used as drug nanocarriers for targeting cancer cells. Therefore, nanostructure observation of particles and micelles in their native liquid condition is indispensable for analysing their function and mechanisms. However, traditional optical and scanning electron microscopy have difficulty observing the nanostructures of aqueous micelles. Recently, we developed a novel imaging technique called scanning electron-assisted dielectric microscopy (SE-ADM) that enables observation of various biological specimens in water with very little radiation damage and high-contrast imaging without staining or fixation at an 8-nm spatial resolution...
August 2, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28770217/dairy-cows-naturally-infected-with-bovine-leukemia-virus-exhibit-abnormal-b-and-t-cell-phenotypes-after-primary-and-secondary-exposures-to-keyhole-limpet-hemocyanin
#12
Meredith C Frie, Kelly R B Sporer, Oscar J Benitez, Joseph C Wallace, Casey J Droscha, Paul C Bartlett, Paul M Coussens
Bovine leukemia virus (BLV) is a retrovirus that is highly prevalent in US dairy herds: over 83% are BLV infected and the within-herd infection rate can be almost 50% on average. While BLV is known to cause lymphosarcomas, only 5% or fewer infected cattle will develop lymphoma; this low prevalence of cancer has historically not been a concern to dairy producers. However, more recent research has found that BLV(+) cows without lymphoma produce less milk and have shorter lifespans than uninfected herdmates. It has been hypothesized that BLV infection interferes with normal immune function in infected cattle, and this could lead to reduced dairy production...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28760341/biological-effects-of-anti-rankl-antibody-administration-in-pregnant-mice-and-their-newborns
#13
Nobuaki Okamatsu, Nobuhiro Sakai, Akiko Karakawa, Naoka Kouyama, Yurie Sato, Katsunori Inagaki, Yuji Kiuchi, Katsuji Oguchi, Takako Negishi-Koga, Masamichi Takami
Denosumab, a fully human monoclonal antibody that neutralizes receptor activator of nuclear factor-κB ligand (RANKL) and blocks osteoclast differentiation, has received approval in Japan for use as an anti-resorptive drug for osteoporosis and skeletal-related events (SREs) in patients with solid cancer. Denosumab is contraindicated during pregnancy, though the effects of blocking RANKL activity on pregnant mothers and their newborns are unclear. We used mice to investigate the effects of an anti-RANKL antibody on maternal and newborn health...
September 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28747709/trimethylamine-n-oxide-abolishes-the-chaperone-activity-of-%C3%AE-casein-an-intrinsically-disordered-protein
#14
Mohd Younus Bhat, Laishram Rajendrakumar Singh, Tanveer Ali Dar
Osmolytes (small molecules that help in circumventing stresses) are known to promote protein folding and prevent aggregation in the case of globular proteins. However, the effect of such osmolytes on the structure and function of intrinsically disordered proteins (IDPs) has not been clearly understood. Here we have investigated the effect of methylamine osmolytes on α-casein (an IDP present in mammalian milk) and discovered that TMAO (Trimethylamine-N-oxide) but not other methylamines renders α-casein functionless...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28736047/health-risk-assessment-as-an-approach-to-manage-an-old-landfill-and-to-propose-integrated-solid-waste-treatment-a-case-study-in-italy
#15
O Paladino, M Massabò
The aim of the present paper is to show how an approach based on human health risk analysis can be used as a decisional tool for the evaluation of impacts on population and for deciding between different waste treatment processes. The situation in which the increasing production of solid wastes cannot be confined in the old existing Municipal Solid Waste landfill (settled in Genoa, Liguria Region, Italy) is used as a case study. Risk assessment for human health due to air, surface water, groundwater and soil contamination is performed in different scenarios for the old landfill and compared with alternative Waste-to-Energy management solutions that consider thermal treatment by gasification of the total waste or gasification of the dry fraction coupled with anaerobic digestion of the wet fraction, plus biogas combustion with or without sludge and bottom ash/slag disposal in the old landfill...
July 20, 2017: Waste Management
https://www.readbyqxmd.com/read/28735581/independent-associations-of-dairy-and-calcium-intakes-with-colorectal-cancers-in-the-adventist-health-study-2-cohort
#16
Yessenia Tantamango-Bartley, Synnove F Knutsen, Karen Jaceldo-Siegl, Jing Fan, Andrew Mashchak, Gary E Fraser
OBJECTIVE: Results associating dairy and Ca intakes with colorectal cancer (CRC) risk have been mixed. Most previous analyses have suffered from confounding between dairy and Ca intakes. We examined independent associations between these variables, also dairy foods, and CRC incidence in a population with a large range of dairy intakes. DESIGN: Adventist Health Study-2 is a cohort study where subjects were enrolled 2002-2007. Proportional hazard regression analyses were performed to estimate hazard ratios (HR)...
July 24, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28714565/mri-compatible-breast-rib-phantom-for-evaluating-ultrasonic-thermal-exposures
#17
Georgios Menikou, Marinos Yiannakou, Christos Yiallouras, Cleanthis Ioannides, Christakis Damianou
INTRODUCTION: The target of this study was the development of a magnetic resonance imaging (MRI) compatible breast phantom for focused ultrasound which includes plastic (ABS) ribs. The objective of the current study was the evaluation of a focused ultrasound procedure using the proposed phantom that eliminates rib heating. MATERIAL AND METHODS: The proposed phantom was evaluated using two different focused ultrasound exposures. The surrounding breast tissue was mimicked using an agar-silica-evaporation milk gel (2% w/v - 2% w/v - 40% v/v)...
July 17, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28688542/evaluation-of-apoptotic-activity-of-withania-coagulans-methanolic-extract-against-human-breast-cancer-and-vero-cell-lines
#18
Rumana Ahmad, Afreen Fatima, A N Srivastava, Mohsin Ali Khan
BACKGROUND: The genus Withania (Family: Solanaceae) holds an important position in Ayurveda, the Indian traditional system of medicine. Withania somnifera Dunal and Withania coagulans Dunal have been documented in folklore as panaceas for various ailments since time immemorial. W. coagulans (WC), commonly called as Indian cheese maker is used for fermenting milk for cheese production in various parts of India. OBJECTIVES: In the study, in vitro cytotoxicity of methanolic extract of dried fruits (berries) of WC was evaluated in a dose dependent manner using trypan blue dye exclusion method against human breast cancer cell line MDA-MB-231 and normal kidney epithelial cell line Vero in the range 20-200 μg/ml...
July 6, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28686955/targeting-stat3-with-silibinin-to-improve-cancer-therapeutics
#19
REVIEW
Joaquim Bosch-Barrera, Bernardo Queralt, Javier A Menendez
Signal transducer and activator of transcription 3 (STAT3) has a prominent role in mediating resistance to conventional chemo-/radio-therapies and modern targeted drugs. While a number of STAT3 inhibitors have been shown to enhance the efficacy of therapeutic agents in vitro, the majority of them have yet to enter clinical evaluation mostly because of lack of efficacy issues. Silibinin is the main component of the silymarin complex, a standardized extract obtained from the seeds of the milk thistle herb Silybum marianum...
July 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28681026/a-seasonal-study-for-determination-of-aflatoxin-m1-level-in-dairy-products-in-iranshahr-iran
#20
N Sohrabi, H Gharahkoli
BACKGROUND AND PURPOSE: Aflatoxin M1, in milk and dairy products, is classified by the International Agency for Research on Cancer as human carcinogens (class 2B). The aim of this study was to evaluate aflatoxin M1 contamination level in dairy products from Iranshahr city, Iran, using ELISA technique. MATERIALS AND METHODS: In our study, 87 samples of milk, white cheese, yoghurt, and butter were collected in different seasons and after preparation, were analyzed by ELISA technique...
September 2016: Advances in Medical Mycology (Iran)
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