Roberto Bonanni, Sonia Gino Grillo, Ida Cariati, Lucia Tranquillo, Riccardo Iundusi, Elena Gasbarra, Virginia Tancredi, Umberto Tarantino
Osteosarcopenia (OSP) is a geriatric syndrome characterized by the coexistence of osteoporosis and sarcopenia and associated with an increased risk of fragility fractures, disability, and mortality. For patients with this syndrome, musculoskeletal pain represents the most significant challenge since, in addition to limiting the individual's functionality and promoting disability, it has a huge psychological burden involving anxiety, depression, and social withdrawal. Unfortunately, the molecular mechanisms involved in the development and persistence of pain in OSP have not yet been fully elucidated, although immune cells are known to play a key role in these processes...
April 26, 2023: Biomedicines