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spine endodermal tumor

Jesse J Savage, James N Casey, Ian T McNeill, Jonathan H Sherman
Neurenteric cysts account for 0.7-1.3% of spinal axis tumors. These rare lesions result from the inappropriate partitioning of the embryonic notochordal plate and presumptive endoderm during the third week of human development. Heterotopic rests of epithelium reminiscent of gastrointestinal and respiratory tissue lead to eventual formation of compressive cystic lesions of the pediatric and adult spine. Histopathological analysis of neurenteric tissue reveals a highly characteristic structure of columnar or cuboidal epithelium with or without cilia and mucus globules...
January 2010: Journal of Craniovertebral Junction and Spine
Peter Kan, Oren N Gottfried, Deborah T Blumenthal, James K Liu, Karen L Salzman, Jeannette Townsend, Randy L Jensen
OBJECT: Central nervous system primary germ cell tumors are typically pineal or suprasellar. Primary germ cell tumors of the spinal axis are very rare, with only a few case reports of germinomas and teratomas described in the literature. METHODS: We present the unique case of a 25-year-old woman with an intradural, extramedullary primary yolk sac tumor (YST) at and below the level of the conus medullaris. The patient was treated with a subtotal resection and within a month had rapid regrowth of her YST...
July 2006: Journal of Neuro-oncology
A Guzel, M Tatli, D Belen, H Seckin
STUDY DESIGN: Case report. OBJECTIVE: To report an adult male patient with a primary extragonadal giant yolk sac tumor presenting with acute spinal cord compression. SETTING: Faculty of Medicine, University of Dicle, Diyarbakir, Turkey. METHOD: A 31-year-old man was referred to our department with a diagnosis of Pott's disease, a complaint of back pain and gait difficulty for 2 weeks. Neurological examination showed spastic paraparesis and hypoesthesia below the L2 dermatome level...
March 2007: Spinal Cord
P Tsitsopoulos, C Rizos, D Isaakidis, G Liapi, S Zymaris
STUDY DESIGN: A case report of intramedullary spinal cord teratoma with remote diastematomyelia in a female adult. OBJECTIVE: To present a rare case of a dysembryogenic spinal tumor with concurrent split cord malformation and to define the importance of early surgical removal of the tumor. SETTING: A department of neurosurgery in Greece. METHODS: A 44-year old woman, presented with progressive lower limb muscle weakness, gait disturbances and dysesthesias in the trunk and lower extremity...
October 2006: Spinal Cord
Taichi Tsuji, Yukihiro Matsuyama, Koji Sato, Hisashi Iwata
We report an infant with a thoracic intradural extramedullary tumor to illustrate the presentation of an infantile spinal cord tumor and the difficulty in establishing a diagnosis. An infant presented with edema of the legs, motor loss in the lower extremities, and anuria at 3 months of age. Magnetic resonance imaging of the lumbar region did not reveal any abnormalities. At 1 year of age, the patient underwent surgery to correct urinary incontinence of unknown etiology. The patient developed gait disturbance and had abdominal pain at 17 months of age...
January 2002: Journal of Pediatric Orthopedics. Part B
Y Nonomura, K Miyamoto, E Wada, H Hosoe, H Nishimoto, H Ogura, K Shimizu
STUDY DESIGN: Two case reports of intramedullary teratoma in the spinal cord of adults, and a review of the literature. OBJECTIVE: To investigate and describe unusual cases of spinal teratoma using MRI to define features that may be used to avoid misdiagnosis. SETTING: A department of orthopedic surgery in Japan. METHODS: One patient, a 37-year-old woman, was referred because of gait disturbance. She was evaluated by myelography, CT scan with myelography, and MRI...
January 2002: Spinal Cord
M Uchino, M Nemoto, T Ohtsuka, Y Seiki, I Shibata
Primary germinoma of the central nervous system carries a good prognosis because of their radiosensitivity. Recurrence is rare and extraneural metastases are even more unusual. We report a unique case of a primary intracranial germinoma exhibiting complete response to radiotherapy, but recurring as an intra-abdominal yolk sac tumor. The presence of a VP shunt is thought to have facilitated metastatic spread of the intracranial neoplasm. An 21-year-old (corrected) male was admitted with headache and consciousness disturbance...
March 1999: No Shinkei Geka. Neurological Surgery
P L Robertson, R C DaRosso, J C Allen
The 5 year survival for patients with malignant intracranial non-germinoma germ cell tumors (NGGCT) which include endodermal sinus tumors, embryonal carcinomas, choriocarcinomas and immature teratomas is less than 25% following a small resection and radiotherapy. In an effort to improve the survival of these patients, an approach using an attempt at radical resection where feasible followed by multi-modality 'sandwich' therapy (chemotherapy-radiation-chemotherapy) was used to treat 18 newly diagnosed patients between 1986 and 1994 in a multi-institution study...
March 1997: Journal of Neuro-oncology
K Matsumoto, E Kohmura, K Tsuruzono, K Mori, Y Araki, T Tsujimura, K Kawano
A 61-year-old man presented with repeated back pain and progressive anesthesia of both lower limbs. MR images and myelography showed an intradural, extramedullary tumor at the Th8-9 level. Surgery revealed a thin membrane containing xanthochromic cerebrospinal fluid behind the spinal cord. Microscopically, the excised lesions contained columnar epithelium with goblet cells. Spinal neurenteric cysts are a rare anomaly, especially solitary cysts located in the thoracic spine. The neurenteric canal transiently develops in the lumbosacral region during the 3rd week of gestation...
January 1994: Nō to Shinkei, Brain and Nerve
J den Boon, C J Avezaat, A van der Gaast, W Koops, F J Huikeshoven
We report on a case of a 46-year-old woman with a conus-cauda syndrome due to an endodermal sinus tumor of the right ovary with multiple metastases in the spine and pelvic bone. Before removing the tumor surgically, combination chemotherapy was given to treat the metastases, which threatened to compromise the spinal cord.
April 1995: Gynecologic Oncology
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