keyword
MENU ▼
Read by QxMD icon Read
search

Pathogenesis AND Tuberculosis

keyword
https://www.readbyqxmd.com/read/29143375/an-immunoinformatics-approach-to-define-t-cell-epitopes-from-polyketide-and-non-ribosomal-peptide-synthesis-proteins-of-mycobacterium-tuberculosis-as-potential-vaccine-candidates
#1
S Dhivya, V Baskar, S R Kumar, R Sathishkumar
The role of polyketide and non-ribosomal proteins from the class of small molecule metabolism of Mycobacterium tuberculosis is well documented in envelope organization, virulence, and pathogenesis. Consequently, the identification of T cell epitopes from these proteins could serve to define potential antigens for the development of vaccines. Fourty-one proteins from polyketide and non-ribosomal peptide synthesis of small molecule metabolism proteins of M tuberculosis H37Rv were analyzed computationally for the presence of HLA class I binding nanomeric peptides...
November 16, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/29116636/pe-and-ppe-genes-a-tale-of-conservation-and-diversity
#2
Giovanni Delogu, Michael J Brennan, Riccardo Manganelli
PE and PPE are two large families of proteins typical of mycobacteria whose structural genes in the Mycobacterium tuberculosis complex (MTBC) occupy about 7% of the total genome. The most ancestral PE and PPE proteins are expressed by genes that belong to the same operon and in most cases are found inserted in the esx clusters, encoding a type VII secretion system. Duplication and expansion of pe and ppe genes, coupled with intragenomic and intergenomic recombination events, led to the emergence of the polymorphic pe_pgrs and ppe_mptr genes in the MTBC genome...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29109555/pathogenesis-of-hiv-1-and-mycobacterium-tuberculosis-co-infection
#3
REVIEW
Lucy C K Bell, Mahdad Noursadeghi
Co-infection with Mycobacterium tuberculosis is the leading cause of death in individuals infected with HIV-1. It has long been known that HIV-1 infection alters the course of M. tuberculosis infection and substantially increases the risk of active tuberculosis (TB). It has also become clear that TB increases levels of HIV-1 replication, propagation and genetic diversity. Therefore, co-infection provides reciprocal advantages to both pathogens. In this Review, we describe the epidemiological associations between the two pathogens, selected interactions of each pathogen with the host and our current understanding of how they affect the pathogenesis of TB and HIV-1/AIDS in individuals with co-infections...
November 7, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/29109018/effect-of-mycobacterium-tuberculosis-infection-on-adipocyte-physiology
#4
Janeesh Plakkal Ayyappan, Christopher Vinnard, Selvakumar Subbian, Jyothi F Nagajyothi
Tuberculosis (TB) remains as a major threat to human health worldwide despite of the availability of standardized antibiotic therapy. One of the characteristic of pathogenic Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis is its ability to persist in the host in a dormant state and develop latent infection without clinical signs of active disease. However, the mechanisms involved in bacterial persistence and the establishment of latency is not well understood. Adipose tissue is emerging as an important niche that favors actively replicating as well as dormant Mtb during acute and latent infection...
November 8, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/29101376/antibiotics-induce-polarization-of-pleural-macrophages-to-m2-like-phenotype-in-patients-with-tuberculous-pleuritis
#5
Sisi Wang, Jian Zhang, Liyan Sui, Hao Xu, Qianling Piao, Ying Liu, Xinglong Qu, Ying Sun, Lei Song, Dan Li, Liping Peng, Shucheng Hua, Guangan Hu, Jianzhu Chen
Pleural macrophages play critical roles in pathogenesis of tuberculous pleuritis, but very little is known about their response to anti-tuberculosis antibiotics treatment. Here, we examined whether and how pleural macrophages change in phenotype, transcription and function following antibiotics treatment in patients with tuberculous pleuritis. Results show pro-inflammatory cytokines were down-regulated significantly post antibiotic treatment in the pleural effusions and pleural macrophages up-regulated markers characteristic of M2 macrophages such as CD163 and CD206...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29095300/rare-esophageal-ulcers-related-to-beh%C3%A3-et-disease-a-case-report
#6
Ning Jia, Yanping Tang, Huayi Liu, Yang Li, Simiao Liu, Lei Liu
RATIONALE: The fundamental pathogenesis of Behçet disease (BD) is still unclear and controversial. Many cases of oral aphthous ulcers and genital ulcers related to BD are reported; nevertheless, idiopathic giant esophageal ulcers related to BD are rare. A rare case for esophageal ulcers related to BD is presented. PATIENT CONCERNS: In China, BD is represented with esophageal involvement which is called esophageal BD (EBD). DIAGNOSES: A 56-year-old man diagnosed to the Gastroenterology Department of Integrated Traditional Chinese and Western Medicine Hospital, for multiple discrete, elliptical esophageal ulcers related to BD...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29090221/ifn-%C3%AE-boosting-of-mycobacterium-bovis-bacillus-calmette-g%C3%A3-erin-vaccine-promoted-th1-type-cellular-response-and-protection-against-m-tuberculosis-infection
#7
C E Rivas-Santiago, G G Guerrero
The role of type I IFNs in the pathogenesis and control of mycobacterial infection is still controversial. It has been reported that type I IFNs exacerbated M. tuberculosis infection through hampering Th1 type cellular immune response. However, under certain conditions they can act as natural immune adjuvants for commercial vaccines. At this point, we have reported recently that successive IFN-alpha boosting of Mycobacterium bovis Bacillus Calmette Güerin (BCG) vaccinated mice protected adult mice from intradermal M...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29089945/the-role-of-mast-cells-in-tuberculosis-orchestrating-innate-immune-crosstalk
#8
REVIEW
Karen M Garcia-Rodriguez, Anu Goenka, Maria T Alonso-Rasgado, Rogelio Hernández-Pando, Silvia Bulfone-Paus
Tuberculosis causes more annual deaths globally than any other infectious disease. However, progress in developing novel vaccines, diagnostics, and therapies has been hampered by an incomplete understanding of the immune response to Mycobacterium tuberculosis (Mtb). While the role of many immune cells has been extensively explored, mast cells (MCs) have been relatively ignored. MCs are tissue resident cells involved in defense against bacterial infections playing an important role mediating immune cell crosstalk...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29080066/choosing-first-line-biologic-treatment-for-moderate-to-severe-psoriasis-what-does-the-evidence-say
#9
Mina Amin, Daniel J No, Alexander Egeberg, Jashin J Wu
An advanced understanding of the pathogenesis of psoriasis has led to the development of multiple therapeutic options for moderate-to-severe psoriasis. Tumor necrosis factor inhibitors, ustekinumab, interleukin-17 inhibitors, and guselkumab (an interleukin-23 inhibitor recently approved for psoriasis) are commercially available biologic agents for psoriasis. Evidence from clinical trials provides pertinent information regarding the safety and efficacy of biologic agents for psoriasis, which should be integrated into clinical decision making...
October 27, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29067986/modelling-of-cerebral-tuberculosis-in-balb-c-mice-using-clinical-strain-from-patients-with-cns-tuberculosis-infection
#10
Aliabbas A Husain, Umesh Datta Gupta, Pushpa Gupta, Amit R Nayak, Nitin H Chandak, Hatim F Daginawla, Lokendra Singh, Rajpal Singh Kashyap
BACKGROUND & OBJECTIVES: Central nervous system (CNS) infection caused by Mycobacterium tuberculosis (MTB) is the most severe form of extrapulmonary tuberculosis (EPTB) due to a high level of mortality and morbidity. Limited studies are available on CNS-TB animal model development. The present study describes the development of a murine model of CNS-TB using a clinical strain (C3) isolated from the cerebrospinal fluid (CSF) of CNS-TB patients. METHODS: Groups of mice were infected by the intravenous route with MTB C3 strain isolated from the CSF of CNS-TB patients...
June 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29050778/the-expressions-and-roles-of-different-forms-of-il-22-in-mycobacterium-tuberculosis-infection
#11
Yuanyuan Liu, Qinfang Ou, Qianqian Liu, Yan Gao, Jing Wu, Bingyan Zhang, Xinhua Weng, Lingyun Shao, Wenhong Zhang
Despite evidence suggesting an anti-Mycobacterium tuberculosis effector function of CD4+ T cells that produce and retain IL-22 in macaques, the general role of IL-22 in tuberculosis infection is still poorly characterized. To explore the immune mechanism in the pathogenesis of tuberculosis in humans, here we evaluated different forms of IL-22 in populations with different tuberculosis infection statuses. We enrolled 156 subjects including 49 patients with pulmonary tuberculosis, 27 patients with tuberculous pleurisy (TPE), 38 individuals with latent tuberculous infection (LTBI) and 42 healthy controls (HC)...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29050759/modeling-tuberculosis-pathogenesis-through-ex-vivo-lung-tissue-infection
#12
Pilar Carranza-Rosales, Irma Edith Carranza-Torres, Nancy Elena Guzmán-Delgado, Gerardo Lozano-Garza, Licet Villarreal-Treviño, Carmen Molina-Torres, Javier Vargas Villarreal, Lucio Vera-Cabrera, Jorge Castro-Garza
Tuberculosis (TB) is one of the top 10 causes of death worldwide. Several in vitro and in vivo experimental models have been used to study TB pathogenesis and induction of immune response during Mycobacterium tuberculosis infection. Precision cut lung tissue slices (PCLTS) is an experimental model, in which all the usual cell types of the organ are found, the tissue architecture and the interactions amongst the different cells are maintained. PCLTS in good physiological conditions, monitored by MTT assay and histology, were infected with either virulent Mycobacterium tuberculosis strain H37Rv or the TB vaccine strain Mycobacterium bovis BCG...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29044950/biochemical-characterization-of-argininosuccinate-lyase-from-m-tuberculosis-significance-of-a-c-terminal-cysteine-in-catalysis-and-thermal-stability
#13
Archita Mishra, Avadhesha Surolia
Arginine biosynthesis pathway is crucial to the survival and pathogenesis of Mycobacterium tuberculosis (Mtb). Arginine is a critical amino acid that contributes to the inflection of cellular immune responses during pathogenesis. Argininosuccinate lyase from Mtb (MtArgH), the last enzyme in the pathway, catalyzes the production of arginine from argininosuccinic acid. MtArgH is an essential enzyme for the growth and survival of M. tuberculosis. We biochemically characterized MtArgH and deciphered the role of a previously unexplored cysteine (Cys(441) ) residue at the C-terminal region of the protein...
November 2017: IUBMB Life
https://www.readbyqxmd.com/read/29032183/peroxiredoxin-1-of-macrophage-is-critical-for-mycobacterial-infection-and-is-controlled-by-early-secretory-antigenic-target-protein-through-the-activation-of-p38-mapk
#14
Shivraj M Yabaji, Alok K Mishra, Aditi Chatterjee, Rikesh K Dubey, Kanchan Srivastava, Kishore K Srivastava
Early secretory antigenic target protein (ESAT-6) is an important virulent factor which plays a crucial role in Mycobacterium tuberculosis (MTB) pathogenesis. Here, we demonstrate the role of ESAT-6 in phagocytosis and intracellular survival of mycobacteria through a mechanism mediated by regulation of a host protein; Peroxiredoxin-1 (Prdx-1). Prdx-1 is an anti-apoptotic and stress response protein which protects cells from damage by ROS and H2O2. The J774 A.1 cells infected with MTB or over-expressing ESAT-6 through eukaryotic promoter vector showed elevated expression of Prdx-1...
October 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29022535/gender-disparities-in-pulmonary-hypertension-at-a-tertiary-centre-in-cameroon
#15
L N Aminde, A Dzudie, A P Kenge, J Ndjebet, S Mapoh, X Kuelang, F Kamdem, B H Mbatchou Ngahane, M-S Doualla, K B Ngu, K Sliwa, F Thienemann
BACKGROUND: Pulmonary hypertension (PH) is a potent cause of heart failure and has been little investigated in the African setting. OBJECTIVE: To investigate the effects of gender on the clinical presentation, echocardiographic features and outcomes of patients with PH in Douala, Cameroon. METHODS: A prospective cohort study was conducted from March 2012 to December 2013 as part of the Pan African Pulmonary Hypertension Cohort study. PH was diagnosed by echocardiography and defined as a right ventricular systolic pressure >35 mmHg in the absence of acute right heart failure...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29018126/systematic-identification-of-mycobacterium-tuberculosis%C3%A2-effectors-reveals-that-bfrb-suppresses-innate-immunity
#16
Xiang He, He-Wei Jiang, Hong Chen, Hainan Zhang, Yin Liu, Zhao-Wei Xu, Fanlin Wu, Shu-Juan Guo, Jing-Li Hou, Mingkun Yang, Wei Yan, Jiaoyu Deng, Lijun Bi, Xian-En Zhang, Sheng-Ce Tao
Mycobacterium tuberculosis (Mtb) has evolved multiple strategies to counter the human immune system. The effectors of Mtb play important roles in the interactions with the host. However, due to the lack of highly efficient strategies, there are only a handful of known Mtb effectors, thus hampering our understanding of Mtb pathogenesis. In this study, we probed Mtb proteome microarray with biotinylated whole-cell lysates of human macrophages, identifying 27 Mtb membrane proteins and secreted proteins that bind to macrophage proteins...
October 10, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28969988/shaping-the-niche-in-macrophages-genetic-diversity-of-the-m-tuberculosis-complex-and-its-consequences-for-the-infected-host
#17
REVIEW
Norbert Reiling, Susanne Homolka, Thomas A Kohl, Christine Steinhäuser, Katharina Kolbe, Stefan Schütze, Julius Brandenburg
Pathogenic mycobacteria of the Mycobacterium tuberculosis complex (MTBC) have co-evolved with their individual hosts and are able to transform the hostile environment of the macrophage into a permissive cellular habitat. The impact of MTBC genetic variability has long been considered largely unimportant in TB pathogenesis. Members of the MTBC can now be distinguished into three major phylogenetic groups consisting of 7 phylogenetic lineages and more than 30 so called sub-lineages/subgroups. MTBC genetic diversity indeed influences the transmissibility and virulence of clinical MTBC isolates as well as the immune response and the clinical outcome...
September 14, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28955956/modeling-molecular-docking-probing-catalytic-binding-mode-of-acetyl-coa-malate-synthase-g-in-brucella-melitensis-16m
#18
Pradeepkiran Jangampalli Adi, Nanda Kumar Yellapu, Bhaskar Matcha
There are enormous evidences and previous reports standpoint that the enzyme of glyoxylate pathway malate synthase G (MSG) is a potential virulence factor in several pathogenic organisms, including Brucella melitensis 16M. Where the lack of crystal structures for best candidate proteins like MSG of B. melitensis 16M creates big lacuna to understand the molecular pathogenesis of brucellosis. In the present study, we have constructed a 3-D structure of MSG of Brucella melitensis 16M in MODELLER with the help of crystal structure of Mycobacterium tuberculosis malate synthase (PDB ID: 2GQ3) as template...
December 2016: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28947646/rhesus-macaques-are-more-susceptible-to-progressive-tuberculosis-than-cynomolgus-macaques-a-quantitative-comparison
#19
Pauline Maiello, Robert M DiFazio, Anthony M Cadena, Mark A Rodgers, Philana Ling Lin, Charles A Scanga, JoAnne L Flynn
In the past two decades, it has become increasingly clear that non-human primates, specifically macaques, are useful models for human tuberculosis (TB). Several macaque species have been used for TB studies, and questions remain about the similarities and differences in TB pathogenesis among macaque species, which can complicate decisions about the best species for a specific experiment. Here we provide a quantitative assessment, using serial positron emission tomography and computed tomography (PET-CT) imaging and precise quantitative determination of bacterial burdens, of low-dose M...
September 25, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28941042/nanomaterials-in-the-prevention-diagnosis-and-treatment-of-mycobacterium-tuberculosis-infections
#20
REVIEW
Kaijin Xu, Zhen Chang Liang, Xin Ding, Haiyang Hu, Shaoqiong Liu, Martin Nurmik, Sheng Bi, Feishu Hu, Zhongkang Ji, Jingjing Ren, Shigui Yang, Yi Yan Yang, Lanjuan Li
Despite the tremendous advancements that have been made in biomedical research, Mycobacterium tuberculosis (TB) still remains one of the top 10 causes of death worldwide, outpacing the Human Immunodeficiency Virus as a leading cause of death from an infectious disease. In the light of such significant disease burden, tremendous efforts have been made worldwide to stem this burgeoning spread of disease. The use of nanomaterials in TB management has increased in the past decade, particularly in the areas of early TB detection, prevention, and treatment...
September 21, 2017: Advanced Healthcare Materials
keyword
keyword
97450
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"