keyword
MENU ▼
Read by QxMD icon Read
search

FABP4 prostate cancer

keyword
https://www.readbyqxmd.com/read/29733540/fabp4-suppresses-proliferation-and-invasion-of-hepatocellular-carcinoma-cells-and-predicts-a-poor-prognosis-for-hepatocellular-carcinoma
#1
Cheng-Qian Zhong, Xiu-Ping Zhang, Ning Ma, Er-Bin Zhang, Jing-Jing Li, Ya-Bo Jiang, Yu-Zhen Gao, Yan-Mei Yuan, Shi-Qian Lan, Dong Xie, Shu-Qun Cheng
Adipocyte fatty acid-binding protein (FABP4) is abundant in macrophage and adipocyte. It is known to be involved in lipid metabolism. The role of FABP4 has been reported in various cancers, such as non-small cell lung cancer, breast cancer, ovarian cancer, and prostatic cancer. However, its role remains unclear in hepatocellular carcinoma (HCC). In our study, we investigated the expression of FABP4 at both mRNA and protein levels, and by examining 175 cases of patients with cancer of the liver tissue microarray, the significance between the expression of FABP4 and clinical characteristics had been discussed...
May 7, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29593201/adipose-tissue-critical-contributor-to-the-development-of-prostate-cancer
#2
Uehara Hisanori, Tomoko Kobayashi, Minoru Matsumoto, Shunsuke Watanabe, Akiko Yoneda, Bando Yoshimi
The prostate is surrounded by periprostatic adipose tissue. Although adipose tissue was thought to play limited physiological roles, it has recently been recognized as an active endocrine organ, secreting growth factors and adipokines. Epidemiologically, obesity is associated with prostate cancer progression. A major mechanism to explain the link between obesity and cancer includes the insulin and insulin-like growth factor (IGF)-1 axis, sex steroids, and adipokines. When prostate cancer cells invade periprostatic adipose tissue, adipose tissue contributes to create the tumor microenvironment, mainly via adipokine secretion...
2018: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/29534587/an-extensive-study-of-the-mechanism-of-prostate-cancer-metastasis
#3
Y Wang, W Guo, H Xu, X Zhu, T Yu, Z Jiang, Q Jiang, X Gang
The study aimed to identify the pivotal genes and pathways involved in prostate cancer metastasis. Using the expression profile dataset GSE7930, downloaded from the Gene Expression Omnibus (GEO) database, differentially expressed genes (DEGs) between primary and highly metastatic prostate cell samples were screened, followed by functional analysis and tumor associated genes (TAG) screening. Protein-protein interaction (PPI) network of DEGs was constructed and module analysis was performed. The expression of DEGs and pathway related genes were evaluated by PCR analysis and the migra- tion ability of prostate tumor cells was observed after FABP4-siRNA blocking...
2018: Neoplasma
https://www.readbyqxmd.com/read/29340091/fatty-acid-binding-protein-4-enhances-prostate-cancer-progression-by-upregulating-matrix-metalloproteinases-and-stromal-cell-cytokine-production
#4
Mingguo Huang, Shintaro Narita, Takamitsu Inoue, Atsushi Koizumi, Mitsuru Saito, Hiroshi Tsuruta, Kazuyuki Numakura, Shigeru Satoh, Hiroshi Nanjo, Takehiko Sasaki, Tomonori Habuchi
Fatty acid binding protein 4 (FABP4) is an abundant protein in adipocytes, and its production is influenced by high-fat diet (HFD) or obesity. The prostate stromal microenvironment induces proinflammatory cytokine production, which is key for the development and progression of prostate cancer (PCa). Here, we show that high FABP4 expression and its secretion by PCa cells directly stimulated PCa cell invasiveness by upregulating matrix metalloproteinases through phosphatidylinositol 3-kinase and mitogen-activated protein kinase signaling pathways...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28163102/the-peritumoural-adipose-tissue-microenvironment-and-cancer-the-roles-of-fatty-acid-binding-protein-4-and-fatty-acid-binding-protein-5
#5
S Guaita-Esteruelas, J Gumà, L Masana, J Borràs
The adipose tissue microenvironment plays a key role in tumour initiation and progression because it provides fatty acids and adipokines to tumour cells. The fatty acid-binding protein (FABP) family is a group of small proteins that act as intracellular fatty acid transporters. Adipose-derived FABPs include FABP4 and FABP5. Both have an important role in lipid-related metabolic processes and overexpressed in many cancers, such as breast, prostate, colorectal and ovarian. Moreover, their expression in peritumoural adipose tissue is deregulated, and their circulating levels are upregulated in some tumours...
February 15, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28049638/leukemic-blasts-program-bone-marrow-adipocytes-to-generate-a-protumoral-microenvironment
#6
Manar S Shafat, Thomas Oellerich, Sebastian Mohr, Stephen D Robinson, Dylan R Edwards, Christopher R Marlein, Rachel E Piddock, Matthew Fenech, Lyubov Zaitseva, Amina Abdul-Aziz, Jeremy Turner, Johnathan A Watkins, Matthew Lawes, Kristian M Bowles, Stuart A Rushworth
Despite currently available therapies, most patients diagnosed with acute myeloid leukemia (AML) die of their disease. Tumor-host interactions are critical for the survival and proliferation of cancer cells; accordingly, we hypothesize that specific targeting of the tumor microenvironment may constitute an alternative or additional strategy to conventional tumor-directed chemotherapy. Because adipocytes have been shown to promote breast and prostate cancer proliferation, and because the bone marrow adipose tissue accounts for up to 70% of bone marrow volume in adult humans, we examined the adipocyte-leukemia cell interactions to determine if they are essential for the growth and survival of AML...
March 9, 2017: Blood
https://www.readbyqxmd.com/read/24740818/exogenous-fatty-acid-binding-protein-4-promotes-human-prostate-cancer-cell-progression
#7
Hisanori Uehara, Tetsuyuki Takahashi, Mina Oha, Hirohisa Ogawa, Keisuke Izumi
Epidemiologic studies have found that obesity is associated with malignant grade and mortality in prostate cancer. Several adipokines have been implicated as putative mediating factors between obesity and prostate cancer. Fatty acid binding protein 4 (FABP4), a member of the cytoplasmic fatty acid binding protein multigene family, was recently identified as a novel adipokine. Although FABP4 is released from adipocytes and mean circulating concentrations of FABP4 are linked with obesity, effects of exogenous FABP4 on prostate cancer progression are unclear...
December 1, 2014: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/24240026/bone-marrow-adipocytes-promote-tumor-growth-in-bone-via-fabp4-dependent-mechanisms
#8
Mackenzie K Herroon, Erandi Rajagurubandara, Aimalie L Hardaway, Katelyn Powell, Audrey Turchick, Daniel Feldmann, Izabela Podgorski
Incidence of skeletal metastases and death from prostate cancer greatly increases with age and obesity, conditions which increase marrow adiposity. Bone marrow adipocytes are metabolically active components of bone metastatic niche that modulate the function of neighboring cells; yet the mechanisms of their involvement in tumor behavior in bone have not been explored. In this study, using experimental models of intraosseous tumor growth and diet-induced obesity, we demonstrate the promoting effects of marrow fat on growth and progression of skeletal prostate tumors...
November 2013: Oncotarget
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"