Richa Verma, Jaikishan Jayakumar, Rebecca Folkerth, Paul R Manger, Mihail Bota, Moitrayee Majumder, Karthika Pandurangan, Stephen Savoia, Srinivasa Karthik, Ramdayalan Kumarasami, Jayaraj Joseph, G Rohini, Sudha Vasudevan, Chitra Srinivasan, S Lata, E Harish Kumar, Rajeswaran Rangasami, Jayaraman Kumutha, S Suresh, Goran Šimić, Partha P Mitra, Mohanasankar Sivaprakasam
Cellular-level anatomical data from early fetal brain are sparse yet critical to the understanding of neurodevelopmental disorders. We characterize the organization of the human cerebral cortex between 13 and 15 gestational weeks using high-resolution whole-brain histological data sets complimented with multimodal imaging. We observed the heretofore underrecognized, reproducible presence of infolds on the mesial surface of the cerebral hemispheres. Of note at this stage, when most of the cerebrum is occupied by lateral ventricles and the corpus callosum is incompletely developed, we postulate that these mesial infolds represent the primordial stage of cingulate, callosal, and calcarine sulci, features of mesial cortical development...
April 2024: Journal of Comparative Neurology