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https://www.readbyqxmd.com/read/28922857/what-can-cortical-development-in-attention-deficit-hyperactivity-disorder-teach-us-about-the-early-developmental-mechanisms-involved
#1
Sara Ambrosino, Patrick de Zeeuw, Lara Marise Wierenga, Sarai van Dijk, Sarah Durston
Studies of Attention-Deficit/Hyperactivity Disorder (ADHD) have shown developmental changes in the cortical mantle. Different dimensions of cortical morphology, such as surface area and thickness, relate to different neurodevelopmental mechanisms. As such, studying multiple dimensions may inform us about the developmental origins of ADHD. Furthermore, results from existing longitudinal samples await replication. Therefore, we conducted a longitudinal study of multiple cortical dimensions in a sizable, independent ADHD sample...
September 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28919574/variation-in-generational-perceptions-of-child-health-and-well-being
#2
Gary L Freed, Matthew M Davis, Dianne C Singer, Acham Gebremariam, Sara L Schultz, Amilcar Matos-Moreno, Mark Wietecha
OBJECTIVE: To assess adults' perceptions regarding the health and well-being of children today relative to their own health and well-being as youth and the potential for intergenerational differences in those perceptions. METHODS: A cross-sectional, internet-based survey of a nationally representative household sample. The study was conducted using GfK Custom Research's web-enabled KnowledgePanel®, a probability-based panel representative of the U.S. POPULATION: We assessed perceptions of children's health and well-being today compared to when respondents were growing up including (1) physical and mental health and (2) children's education, exercise, diet, health care, safety of communities and emotional support from families, groups and organizations...
September 12, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28913874/an-algorithmic-approach-to-diagnose-haematolymphoid-neoplasms-in-effusion-by-combining-morphology-immunohistochemistry-and-molecular-cytogenetics
#3
L Chen, J S Zhang, D G Liu, D Cui, Z L Meng
OBJECTIVE: There are limited studies of cytology diagnosis of haematopoietic and lymphoid tumours in serosal effusion except for occasional case reports. We would like to demonstrate an algorithmic approach for accurate diagnosis, especially in patients without previous history. METHODS: We reviewed 36 cases of lymphoma diagnosed in serosal effusion following an algorithmic approach. Suspected tumour cells were classified into small, intermediate and large sizes and two characteristic forms of plasmacytoid and Reed Sternberg-like on smears (step 1), followed by utilising panels of immunohistochemical markers and Epstein-Barr encoding region in situ hybridisation on cell blocks (step 2)...
September 15, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28912418/genesis-of-ultra-high-ni-olivine-in-high-mg-andesite-lava-triggered-by-seamount-subduction
#4
Tatsuji Nishizawa, Hitomi Nakamura, Tatiana Churikova, Boris Gordeychik, Osamu Ishizuka, Satoru Haraguchi, Takashi Miyazaki, Bogdan Stefanov Vaglarov, Qing Chang, Morihisa Hamada, Jun-Ichi Kimura, Kenta Ueki, Chiaki Toyama, Atsushi Nakao, Hikaru Iwamori
The Kamchatka Peninsula is a prominent and wide volcanic arc located near the northern edge of the Pacific Plate. It has highly active volcanic chains and groups, and characteristic lavas that include adakitic rocks. In the north of the peninsula adjacent to the triple junction, some additional processes such as hot asthenospheric injection around the slab edge and seamount subduction operate, which might enhance local magmatism. In the forearc area of the northeastern part of the peninsula, monogenetic volcanic cones dated at <1 Ma were found...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912297/cyclin-d1-negative-mantle-cell-lymphoma-with-aberrant-cd3-expression
#5
Anita Malek, Govind Bhagat
No abstract text is available yet for this article.
September 14, 2017: Blood
https://www.readbyqxmd.com/read/28911068/early-stage-mantle-cell-lymphoma-a-retrospective-analysis-from-the-international-lymphoma-radiation-oncology-group-ilrog
#6
B S Dabaja, A D Zelenetz, A K Ng, R W Tsang, S Qi, P K Allen, D Hodgson, U Ricardi, R T Hoppe, R Advani, P M Mauch, L S Constine, L Specht, Y Li, S A Terezakis, A Wirth, G Reinartz, H T Eich, B M P Aleman, P Barr, J Yahalom
Background: Mantle cell lymphoma (MCL) rarely presents as early-stage disease, but clinical observations suggest that patients who present with early-stage disease may have better outcomes than those with advanced-stage disease. Patients and methods: In this 13-institution study, we examined outcomes among 179 patients with early-stage (stage I or II) MCL in an attempt to identify prognostic factors that influence treatment selection and outcome. Variables examined included clinical characteristics, treatment modality, response to therapy, sites of failure, and survival...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28910460/sudden-flank-pain-in-a-patient-receiving-ibrutinib-for-mantle-cell-lymphoma
#7
Yu Xi Terence Law, Lui Shiong Lee
No abstract text is available yet for this article.
September 14, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28905990/the-mtor-kinase-inhibitor-everolimus-synergistically-enhances-the-anti-tumor-effect-of-the-bruton-s-tyrosine-kinase-btk-inhibitor-pls-123-on-mantle-cell-lymphoma
#8
Jiao Li, Xiaogan Wang, Yan Xie, Zhitao Ying, Weiping Liu, Lingyan Ping, Chen Zhang, Zhengying Pan, Ning Ding, Yuqin Song, Jun Zhu
Mantle cell lymphoma (MCL) is an aggressive and incurable malignant disease. Despite of general chemotherapy, relapse and mortality are common, highlighting the need for the development of novel targeted drugs or combination of therapeutic regimens. Recently, several drugs that target the B-cell receptor (BCR) signaling pathway, especially the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib, have demonstrated notable therapeutic effects in relapsed/refractory patients, which indicate that pharmacological inhibition of BCR pathway holds promise in MCL treatment...
September 14, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28901456/the-antitumor-effects-of-arsenic-trioxide-in-mantle-cell-lymphoma-via-targeting-wnt-%C3%AE-%C3%A2-catenin-pathway-and-dna-methyltransferase-1
#9
Xin-Yu Li, Ying Li, Lingyan Zhang, Xin Liu, Lili Feng, Xin Wang
Mantle cell lymphoma (MCL) is an aggressive non‑Hodgkin lymphoma (NHL) with poor prognosis. The rapid progression and frequently relapse make it urgent to identify therapeutic agents with potent antitumor effect. Increasing evidence indicated that dysregulation of Wnt/β‑catenin pathway and abnormal methylation appeared to promote tumorigenesis. Arsenic trioxide (As2O3, ATO) has been reported effective in many hematologic malignancies in recent studies, however, the mechanism and effects of ATO in MCL still need further research...
September 7, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28899853/the-potential-for-chemotherapy-free-strategies-in-mantle-cell-lymphoma
#10
Peter Martin, Jia Ruan, John P Leonard
Mantle cell lymphoma (MCL) may be one of the few cancers where multiple chemotherapy and non-chemotherapy regimens are considered as standard. Despite the significant activity of chemotherapy in the first-line setting and beyond, its limitations are reflected in the relatively poor ultimate outcomes of patients with MCL treated in the real world. Highly proliferative MCL and those with TP53 mutations tend to respond poorly despite intensive cytotoxic therapies. Patients with co-morbidities and those that are geographically isolated may not have access to the regimens that may appear most promising in clinical trials...
September 12, 2017: Blood
https://www.readbyqxmd.com/read/28894694/evaluation-of-partial-breast-reirradiation-with-intraoperative-radiotherapy-after-prior-thoracic-radiation-a-single-institution-report-of-outcomes-and-toxicity
#11
Christine Chin, Priya Jadeja, Bret Taback, David P Horowitz, Sheldon M Feldman, Richard Ha, Eileen P Connolly
INTRODUCTION: Mastectomy is the current standard of care for ipsilateral breast tumor recurrences after prior whole breast irradiation (WBI). We report our single-institution experience with breast-conserving surgery (BCS) followed by intraoperative radiotherapy (IORT) as an alternative to salvage mastectomy for new or recurrent breast cancers that develop in the setting of prior thoracic radiation. METHODS: We performed an IRB-approved retrospective review of patients treated with breast IORT between September 2013 and November 2016...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28889011/two-novel-lrr-and-ig-domain-containing-proteins-from-oyster-crassostrea-gigas-function-as-pattern-recognition-receptors-and-induce-expression-of-cytokines
#12
Xiudan Wang, Mengqiang Wang, Qingsong Xu, Jiachao Xu, Zhao Lv, Lingling Wang, Linsheng Song
Leucine-rich repeat (LRR) domain and immunoglobulin (Ig) domain are both competent immune recognition modules, and the immunological roles of LRR and Ig domain containing- proteins (LRRIGs) are speculated to be multifunctional and worth investigating. In the present study, two novel LRRIGs, CgLRRIG-1 and CgLRRIG-2, were identified and characterized from oyster Crassostrea gigas. Both of them contained an N-terminal LRR region, an Ig domain, a transmembrane region, and a C-terminal cytoplasmic tail. The mRNA transcripts of CgLRRIG-1 and CgLRRIG-2 were constitutively expressed in muscle, gill, hepatopancreas, mantle, gonad and hemocytes with the highest expression level in hepatopancreas...
September 6, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28888876/hemolymph-and-gill-carbonic-anhydrase-are-more-sensitive-to-aquatic-contamination-than-mantle-carbonic-anhydrase-in-the-mangrove-oyster-crassostrea-rhizophorae
#13
Matheus Barbosa Dos Santos, Ignácio Evaristo Monteiro Neto, Sarah Rachel Candido de Souza Melo, Enelise Marcelle Amado
Carbonic anhydrase (CA) is a ubiquitous metalloenzyme of great importance in several physiological processes. Due to its physiological importance and sensitivity to various pollutants, CA activity has been used as biomarker of aquatic contamination. Considering that in bivalves the sensitivity of CA to pollutants seems to be tissue-specific, we proposed here to analyze CA activity of hemolymph, gill and mantle of Crassostrea rhizophorae collected in two tropical Brazilian estuaries with different levels of anthropogenic impact, in dry and rainy season...
September 6, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28888537/a-gtp-dependent-phosphoenolpyruvate-carboxykinase-from-crassostrea-gigas-involved-in-immune-recognition
#14
Zhao Lv, Limei Qiu, Weilin Wang, Zhaoqun Liu, Zhuang Xue, Zichao Yu, Xiaorui Song, Hao Chen, Lingling Wang, Linsheng Song
Phosphoenolpyruvate carboxykinase (PEPCK) is well known as a key enzyme involved in the metabolic pathway of gluconeogenesis in organisms, but the information about its involvement in immune response is still very limited. In the present study, a novel PEPCK homolog named CgPEPCK was identified from oyster Crassostrea gigas. The deduced amino acid sequence of CgPEPCK shared 52%-74% similarities with those from other known PEPCKs. There were one conserved guanosine triphosphate (GTP) binding site, one substrate binding site, one metal binding site and one active site in CgPEPCK...
September 6, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28887461/on-the-consistency-of-seismically-imaged-lower-mantle-slabs
#15
G E Shephard, K J Matthews, K Hosseini, M Domeier
The geoscience community is increasingly utilizing seismic tomography to interpret mantle heterogeneity and its links to past tectonic and geodynamic processes. To assess the robustness and distribution of positive seismic anomalies, inferred as subducted slabs, we create a set of vote maps for the lower mantle with 14 global P-wave or S-wave tomography models. Based on a depth-dependent threshold metric, an average of 20% of any given tomography model depth is identified as a potential slab. However, upon combining the 14 models, the most consistent positive wavespeed features are identified by an increasing vote count...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28884745/clinicopathologic-and-genetic-characteristics-of-young-patients-with-pleural-diffuse-malignant-mesothelioma
#16
Marina Vivero, Raphael Bueno, Lucian R Chirieac
Pleural diffuse malignant mesothelioma typically presents during the seventh decade of life and has poor prognosis. Recent epidemiologic studies have shown differences between young and older mesothelioma patients, but the biology of pleural mesothelioma in young patients is poorly understood. We studied the clinicopathologic and genetic characteristics in pleural mesothelioma patients aged 35 years and younger. Thirty-six consecutive pleural mesothelioma patients aged 35 years and younger were compared with 48 older patients...
September 8, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28881919/newly-diagnosed-and-relapsed-mantle-cell-lymphoma-esmo-clinical-practice-guidelines-for-diagnosis-treatment-and-follow-up
#17
M Dreyling, E Campo, O Hermine, M Jerkeman, S Le Gouill, S Rule, O Shpilberg, J Walewski, M Ladetto
No abstract text is available yet for this article.
July 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28878403/growth-of-the-northeastern-margin-of-the-tibetan-plateau-by-squeezing-up-of-the-crust-at-the-boundaries
#18
Jianyu Shi, Danian Shi, Yang Shen, Wenjin Zhao, Guangqi Xue, Heping Su, Yang Song
In classic orogenic models, the mountain range is underlain by a deep crustal root. Here we present the crustal and upper mantle structures along two receiver function profiles across Qilian, an orogen experiencing recent growth at the northern margin of the Tibetan plateau. Opposite to an expected crustal root beneath the orogen, the Moho beneath Qilian is arch-like, shallower beneath the center and deepens by up to 10 km beneath its southern and northern boundaries. Additional velocity interfaces sub-parallel to the Moho are observed in the lower crust of the basins south of Qilian, which we interpret as the top of a mechanically strong lower crust thrusting several tens of kilometers underneath Qilian...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28875507/the-etiology-of-b-cell-lymphoid-malignancies-with-a-focus-on-chronic-inflammation-and-infections
#19
Karin E Smedby, Maurilio Ponzoni
B-cell malignancies are a heterogeneous group of lymphoproliferative disorders with different molecular characteristics and clinical course. It is increasingly recognized that the group displays considerable heterogeneity also regarding etiologic factors. Here, we summarize the latest developments in the etiology of B-cell lymphoid malignancy subtypes focusing on immune perturbation. Severe immune suppression constitues a strong and well established risk factor for aggressive subtypes (e.g., diffuse large B-cell and Burkitt lymphoma), but appears unrelated to risk of common low-grade subtypes (e...
September 5, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28873356/follicular-lymphoma-with-hyaline-vascular-castleman-like-features-analysis-of-6-cases-and-review-of-the-literature
#20
Sergio Pina-Oviedo, Roberto N Miranda, Pei Lin, John T Manning, L Jeffrey Medeiros
Follicular lymphoma (FL) with features reminiscent of hyaline-vascular Castleman disease (CD) is an unusual morphologic variant that may create diagnostic difficulties. To our knowledge, only 5 cases of this variant have been reported. We describe the clinicopathologic features of 6 cases including 2 men and 4 women with a median age of 63years (range, 41-77). Morphologically, all lymph node biopsy specimens showed at least a focal area of conventional FL; 4 cases showed neoplastic follicles with hyalinized blood vessels penetrating into germinal centers (lollipop-like lesions); 4 cases had interfollicular areas with increased vascular stroma, 2 cases showed small neoplastic follicles with prominent, onion skin-like mantle zones, and 1 case showed two or more germinal centers within follicles (twinning)...
September 2, 2017: Human Pathology
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