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https://www.readbyqxmd.com/read/28516958/the-origin-and-degassing-history-of-the-earth-s-atmosphere-revealed-by-archean-xenon
#1
Guillaume Avice, Bernard Marty, Ray Burgess
Xenon (Xe) is an exceptional tracer for investigating the origin and fate of volatile elements on Earth. The initial isotopic composition of atmospheric Xe remains unknown, as do the mechanisms involved in its depletion and isotopic fractionation compared with other reservoirs in the solar system. Here we present high precision analyses of noble gases trapped in fluid inclusions of Archean quartz (Barberton, South Africa) that reveal the isotopic composition of the paleo-atmosphere at ≈3.3 Ga. The Archean atmospheric Xe is mass-dependently fractionated by 12...
May 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28514353/-mantle-dentin-as-biomodel-of-materials-for-structural-teeth-restoration
#2
A V Starodubova, Yu A Vinnichenko, I Ya Pourovskaya, F S Rusanov
The article describes a structural element of natural teeth - mantle dentin. It has been shown that the presence of this element in the structure of a natural tooth largely ensures its strength under the influence of repeated loads in a functional oral environment and arrests crack growth at the enamel/dentine interface. This later effect is explained by the influence of a thin layer of mantle dentine, which has physical and mechanical characteristics different from that of the main dentin.
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28508893/south-american-plate-advance-and-forced-andean-trench-retreat-as-drivers-for-transient-flat-subduction-episodes
#3
Gerben Schepers, Douwe J J van Hinsbergen, Wim Spakman, Martha E Kosters, Lydian M Boschman, Nadine McQuarrie
At two trench segments below the Andes, the Nazca Plate is subducting sub-horizontally over ∼200-300 km, thought to result from a combination of buoyant oceanic-plateau subduction and hydrodynamic mantle-wedge suction. Whether the actual conditions for both processes to work in concert existed is uncertain. Here we infer from a tectonic reconstruction of the Andes constructed in a mantle reference frame that the Nazca slab has retreated at ∼2 cm per year since ∼50 Ma. In the flat slab portions, no rollback has occurred since their formation at ∼12 Ma, generating 'horse-shoe' slab geometries...
May 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28507456/adjuvant-intraoperative-radiotherapy-for-selected-breast-cancers-in-previously-irradiated-women-evidence-for-excellent-feasibility-and-favorable-outcomes
#4
Gladys Blandino, Marina Guenzi, Liliana Belgioia, Elisabetta Bonzano, Elena Configliacco, Elena Tornari, Francesca Cavagnetto, Davide Bosetti, Alessandra Fozza, Daniele Friedman, Renzo Corvò
BACKGROUND: The present report provides preliminary outcomes with intraoperative radiotherapy delivered to women with breast cancer included in a re-irradiation program. MATERIALS AND METHODS: From October 2010 to April 2014, thirty women were included in a re-irradiation protocol by exploiting IORT technique. The median time between the two irradiations was 10 years (range 3-50). All patients underwent conservative surgery, sentinel lymph node excision and IORT with electron beam delivered by a mobile linear accelerator...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28504263/dehydration-driven-stress-transfer-triggers-intermediate-depth-earthquakes
#5
Thomas P Ferrand, Nadège Hilairet, Sarah Incel, Damien Deldicque, Loïc Labrousse, Julien Gasc, Joerg Renner, Yanbin Wang, Harry W Green Ii, Alexandre Schubnel
Intermediate-depth earthquakes (30-300 km) have been extensively documented within subducting oceanic slabs, but their mechanics remains enigmatic. Here we decipher the mechanism of these earthquakes by performing deformation experiments on dehydrating serpentinized peridotites (synthetic antigorite-olivine aggregates, minerals representative of subduction zones lithologies) at upper mantle conditions. At a pressure of 1.1 gigapascals, dehydration of deforming samples containing only 5 vol% of antigorite suffices to trigger acoustic emissions, a laboratory-scale analogue of earthquakes...
May 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28504262/density-structure-of-earth-s-lowermost-mantle-from-stoneley-mode-splitting-observations
#6
Paula Koelemeijer, Arwen Deuss, Jeroen Ritsema
Advances in our understanding of Earth's thermal evolution and the style of mantle convection rely on robust seismological constraints on lateral variations of density. The large-low-shear-wave velocity provinces (LLSVPs) atop the core-mantle boundary beneath Africa and the Pacific are the largest structures in the lower mantle, and hence severely affect the convective flow. Here, we show that anomalous splitting of Stoneley modes, a unique class of free oscillations that are perturbed primarily by velocity and density variations at the core-mantle boundary, is explained best when the overall density of the LLSVPs is lower than the surrounding mantle...
May 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28503306/the-drive-to-generate-multiple-forms-of-oncogenic-cyclin-d1-transcripts-in-mantle-cell-lymphoma
#7
EDITORIAL
Chioniso Patience Masamha
Alternative polyadenylation is a rapidly emerging form of gene regulation, which in its simplest form, enables the generation of mRNA transcripts that code for the same protein but have 3'UTRs of different lengths and regulatory content. For oncogenes, shorter 3'UTRs would be preferred as a mechanism to evade miRNA regulation. The shortening of the 3'UTR of cyclin D1 in mantle cell lymphoma offers provocative insights into this process. Patient samples have revealed that 3'UTR shortening may occur due to mutations, or translocations that result in the generation of a chimeric 3'UTR...
2017: Biomarker Research
https://www.readbyqxmd.com/read/28500352/whole-mantle-convection-with-tectonic-plates-preserves-long-term-global-patterns-of-upper-mantle-geochemistry
#8
T L Barry, J H Davies, M Wolstencroft, I L Millar, Z Zhao, P Jian, I Safonova, M Price
The evolution of the planetary interior during plate tectonics is controlled by slow convection within the mantle. Global-scale geochemical differences across the upper mantle are known, but how they are preserved during convection has not been adequately explained. We demonstrate that the geographic patterns of chemical variations around the Earth's mantle endure as a direct result of whole-mantle convection within largely isolated cells defined by subducting plates. New 3D spherical numerical models embedded with the latest geological paleo-tectonic reconstructions and ground-truthed with new Hf-Nd isotope data, suggest that uppermost mantle at one location (e...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28499928/detection-of-ostreid-herpesvirus-1-microvariants-in-healthy-crassostrea-gigas-following-disease-events-and-their-possible-role-as-reservoirs-of-infection
#9
Olivia Evans, Paul Hick, Richard J Whittington
Ostreid herpesvirus-1 microvariants (OsHV-1) cause severe mortalities in farmed Crassostrea gigas in Europe, New Zealand and Australia. Outbreaks are seasonal, recurring in the warmer months of the year in endemic estuaries. The reference genotype and microvariant genotypes of OsHV-1 have been previously detected in the tissues of apparently healthy adult oysters naturally exposed to OsHV-1 in the field. However, the role of such oysters as reservoirs of infection for subsequent mortality outbreaks remains unclear...
May 9, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28495928/cyclin-d1-negative-blastoid-mantle-cell-lymphoma-exhibiting-cleaved-to-bilobated-cytomorphology
#10
Huan-You Wang, Alexey Hodkoff
No abstract text is available yet for this article.
May 11, 2017: Blood
https://www.readbyqxmd.com/read/28493049/identification-and-differential-expression-of-biomineralization-genes-in-the-mantle-of-pearl-oyster-pinctada-fucata
#11
Haimei Li, Bo Zhang, Sigang Fan, Baosuo Liu, Jiaqi Su, Dahui Yu
A series of proteins are involved in shell formation of the pearl oyster Pinctada fucata, but the involved mechanisms and the relative expression levels of these proteins have not been elucidated. In this study, we sequenced and characterized the transcriptome of P. fucata mantle tissue. A total of 100,679 unique transcripts were assembled, 43687 Unigenes were annotated, and 48654 CDSs were determined. Of these, GO annotated 16353 Unigenes, COG defined 11585 unigenes into 25 categories, and KEGG sorted 25053 unigenes into 258 pathways...
May 10, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28489866/magmatic-evolution-of-panama-canal-volcanic-rocks-a-record-of-arc-processes-and-tectonic-change
#12
David W Farris, Agustin Cardona, Camilo Montes, David Foster, Carlos Jaramillo
Volcanic rocks along the Panama Canal present a world-class opportunity to examine the relationship between arc magmatism, tectonic forcing, wet and dry magmas, and volcanic structures. Major and trace element geochemistry of Canal volcanic rocks indicate a significant petrologic transition at 21-25 Ma. Oligocene Bas Obispo Fm. rocks have large negative Nb-Ta anomalies, low HREE, fluid mobile element enrichments, a THI of 0.88, and a H2Ocalc of >3 wt. %. In contrast, the Miocene Pedro Miguel and Late Basalt Fm...
2017: PloS One
https://www.readbyqxmd.com/read/28482358/continental-crust-formation-on-early-earth-controlled-by-intrusive-magmatism
#13
A B Rozel, G J Golabek, C Jain, P J Tackley, T Gerya
The global geodynamic regime of early Earth, which operated before the onset of plate tectonics, remains contentious. As geological and geochemical data suggest hotter Archean mantle temperature and more intense juvenile magmatism than in the present-day Earth, two crust-mantle interaction modes differing in melt eruption efficiency have been proposed: the Io-like heat-pipe tectonics regime dominated by volcanism and the "Plutonic squishy lid" tectonics regime governed by intrusive magmatism, which is thought to apply to the dynamics of Venus...
May 8, 2017: Nature
https://www.readbyqxmd.com/read/28480764/novel-agents-in-mantle-cell-lymphoma
#14
David Tucker, Simon Rule
Mantle cell lymphoma (MCL) usually takes an aggressive clinical course and carries a poor prognosis. Recently, progress has been made in the treatment of MCL including the development of a number of novel agents which target intracellular pathways and the extracellular microenvironment. These agents have transformed the landscape of available therapeutic options. Areas covered: The current literature on the novel agents which currently hold a licence for the treatment of MCL in the context of front-line therapy and in the relapsed/refractory setting is summarized...
May 17, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28473415/triple-hit-blastoid-mantle-cell-lymphoma-presenting-like-acute-leukemia
#15
Jie Xu, Shaoying Li
No abstract text is available yet for this article.
May 4, 2017: Blood
https://www.readbyqxmd.com/read/28473047/mantle-cell-involvement-of-the-spleen
#16
Lori A Erickson
No abstract text is available yet for this article.
May 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28468797/selective-inhibition-of-nuclear-export-with-selinexor-in-patients-with-non-hodgkin-s-lymphoma
#17
John Kuruvilla, Michael Savona, Rachid Baz, Morten Mau-Sorensen, Nashat Gabrail, Ramiro Garzon, Richard Stone, Michael Wang, Lynn Savoie, Peter Martin, Ian Flinn, Meagan Jacoby, T J Unger, Jean R Saint-Martin, Tami Rashal, Sharon Friedlander, Robert Carlson, Michael Kauffman, Sharon Shacham, Martin Gutierrez
Patients with relapsed or refractory (R/R) non-Hodgkin's lymphoma (NHL) have a poor prognosis and limited treatment options. We evaluated selinexor, an orally bioavailable, first-in-class inhibitor of the nuclear export protein XPO1, in this phase 1 trial to assess safety and determine a recommended phase 2 dose (RP2D). Seventy-nine patients with various NHL histologies, including diffuse large B cell lymphoma (DLBCL), Richter's transformation, mantle cell lymphoma (MCL), follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL) were enrolled...
May 3, 2017: Blood
https://www.readbyqxmd.com/read/28467819/the-concurrent-emergence-and-causes-of-double-volcanic-hotspot-tracks-on-the-pacific-plate
#18
T D Jones, D R Davies, I H Campbell, G Iaffaldano, G Yaxley, S C Kramer, C R Wilson
Mantle plumes are buoyant upwellings of hot rock that transport heat from Earth's core to its surface, generating anomalous regions of volcanism that are not directly associated with plate tectonic processes. The best-studied example is the Hawaiian-Emperor chain, but the emergence of two sub-parallel volcanic tracks along this chain, Loa and Kea, and the systematic geochemical differences between them have remained unexplained. Here we argue that the emergence of these tracks coincides with the appearance of other double volcanic tracks on the Pacific plate and a recent azimuthal change in the motion of the plate...
May 3, 2017: Nature
https://www.readbyqxmd.com/read/28466437/role-of-sox11-and-genetic-events-cooperating-with-cyclin-d1-in-mantle-cell-lymphoma
#19
REVIEW
Sílvia Beà, Virginia Amador
Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm, incurable with current therapies. The t(11;14)(q13;q32) involving cyclin D1 is considered the first oncogenic hit found in virtually all MCLs. However, additional secondary genomic alterations are essential for complete transformation. MCLs are genetically very unstable with several genetic alterations associated with its high proliferative behavior involving several oncogenic pathways. Furthermore, SOX11 is overexpressed in the majority of conventional MCLs (cMCL), including cyclin D1-negative cases, but absent in non-nodal leukemic MCL with indolent clinical behavior (nnMCL)...
June 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28461430/exploring-demand-reduction-through-design-durability-and-usership-of-fashion-clothes
#20
Kate Fletcher
Global planetary boundaries confer limits to production and consumption of material goods. They also confer an obligation to experiment, as individuals and collectively as society, with less-materially-intensive, but no less exuberant, ways of living. This paper takes up this mantle and explores materials demand reduction through a focus on design, fashion garments and the universal, everyday activity of wearing clothes. It takes as its starting point the design of longer-lasting products, a widely favoured strategy for increasing materials efficiency and reducing materials demand in many sectors, including fashion...
June 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
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