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Taurine AND Transcription factor

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https://www.readbyqxmd.com/read/29180230/glucocorticoids-genes-and-brain-function
#1
REVIEW
Grzegorz R Juszczak, Adrian M Stankiewicz
The identification of key genes in transcriptomic data constitutes a huge challenge. Our review of microarray reports revealed 88 genes whose transcription is consistently regulated by glucocorticoids (GCs), such as cortisol, corticosterone and dexamethasone, in the brain. Replicable transcriptomic data were combined with biochemical and physiological data to create an integrated view of the effects induced by GCs. The most frequently reported genes were Errfi1 and Ddit4. Their up-regulation was associated with the altered transcription of genes regulating growth factor and mTORC1 signaling (Gab1, Tsc22d3, Dusp1, Ndrg2, Ppp5c and Sesn1) and progression of the cell cycle (Ccnd1, Cdkn1a and Cables1)...
November 24, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29144408/antioxidant-effect-of-barley-sprout-extract-via-enhancement-of-nuclear-factor-erythroid-2-related-factor-2-activity-and-glutathione-synthesis
#2
Yun-Hee Lee, Sou Hyun Kim, Seunghyun Lee, Kyung-Mi Kim, Jae-Chul Jung, Tae Gen Son, Sung Hwan Ki, Woo-Duck Seo, Jae-Hwan Kwak, Jin Tae Hong, Young-Suk Jung
We previously showed that barley sprout extract (BSE) prevents chronic alcohol intake-induced liver injury in mice. BSE notably inhibited glutathione (GSH) depletion and increased inflammatory responses, revealing its mechanism of preventing alcohol-induced liver injury. In the present study we investigated whether the antioxidant effect of BSE involves enhancing nuclear factor-erythroid 2 related factor 2 (Nrf2) activity and GSH synthesis to inhibit alcohol-induced oxidative liver injury. Mice fed alcohol for four weeks exhibited significantly increased oxidative stress, evidenced by increased malondialdehyde (MDA) level and 4-hydroxynonenal (4-HNE) immunostaining in the liver, whereas treatment with BSE (100 mg/kg) prevented these effects...
November 16, 2017: Nutrients
https://www.readbyqxmd.com/read/29101223/taurine-treatment-prevents-derangement-of-the-hepatic-%C3%AE-glutamyl-cycle-and-methylglyoxal-metabolism-in-a-mouse-model-of-classical-homocystinuria-regulatory-crosstalk-between-thiol-and-sulfinic-acid-metabolism
#3
Kenneth N Maclean, Hua Jiang, Stefanos Aivazidis, Eugene Kim, Colin T Shearn, Peter S Harris, Dennis R Petersen, Robert H Allen, Sally P Stabler, James R Roede
Cystathionine β-synthase-deficient homocystinuria (HCU) is a poorly understood, life-threatening inborn error of sulfur metabolism. Analysis of hepatic glutathione (GSH) metabolism in a mouse model of HCU demonstrated significant depletion of cysteine, GSH, and GSH disulfide independent of the block in trans-sulfuration compared with wild-type controls. HCU induced the expression of the catalytic and regulatory subunits of γ-glutamyl ligase, GSH synthase (GS), γ-glutamyl transpeptidase 1, 5-oxoprolinase (OPLAH), and the GSH-dependent methylglyoxal detoxification enzyme, glyoxalase-1...
November 3, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29052795/effects-of-glutamine-taurine-and-their-association-on-inflammatory-pathway-markers-in-macrophages
#4
Talita Sartori, Guilherme Galvão Dos Santos, Amanda Nogueira-Pedro, Edson Makiyama, Marcelo Macedo Rogero, Primavera Borelli, Ricardo Ambrósio Fock
The immune system is essential for the control and elimination of infections, and macrophages are cells that act as important players in orchestrating the various parts of the inflammatory/immune response. Amino acids play important role in mediating functionality of the inflammatory response, especially mediating macrophages functions and cytokines production. We investigated the influence of glutamine, taurine and their association on the modulation of inflammatory pathway markers in macrophages. The RAW 264...
October 20, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28766169/retinoid-acid-and-taurine-promote-neurod1-induced-differentiation-of-induced-pluripotent-stem-cells-into-retinal-ganglion-cells
#5
Li Huang, Mengfei Chen, Weizhong Zhang, Xuerong Sun, Bingqian Liu, Jian Ge
Induced pluripotent stem cells (iPSCs) possess the capacity to differentiate into multiple cell types including retinal neurons. Despite substantial progress in the transcriptional regulation of iPSC differentiation process, the efficiency of generation of retinal neurons from iPSCs is still low. In this study, we investigated the role of transcription factor NeuroD1 in the differentiation of iPSCs into retinal neurons. We observed that retrovirus-mediated NeuroD1 overexpression in iPSCs increased the efficiency of neuronal differentiation...
August 1, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28412885/antenatal-taurine-supplementation-in-fetal-rats-with-growth-restriction-improves-neural-stem-cell-proliferation-by-inhibiting-the-activities-of-rho-family-factors
#6
Yan Wang, Xiang-Wen Li, Jing Liu, Wei Fu
OBJECTIVE: To investigate whether antenatal taurine supplementation improves neural stem cell proliferation in rats with fetal growth restriction (FGR) through regulating the activity of Rho family factors. METHODS: FGR models were established via food restriction throughout pregnancy. Pregnant rats were randomly divided into the control group, the FGR group (given 40% of the normal daily feeding in the control group), and the Taurine group (FGR model treated with 300 mg/kg·d taurine from gestational day seven)...
May 5, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28229251/taurine-ameliorated-homocysteine-induced-h9c2-cardiomyocyte-apoptosis-by-modulating-endoplasmic-reticulum-stress
#7
Zhimin Zhang, Lianyou Zhao, Yanfen Zhou, Xuanhao Lu, Zhengqiang Wang, Jipeng Wang, Wei Li
Homocysteine (Hcy)-triggered endoplasmic reticulum (ER) stress-mediated endothelial cell apoptosis has been suggested as a cause of Hcy-dependent vascular injury. However, whether ER stress is the molecular mechanism linking Hcy and cardiomyocytes death is unclear. Taurine has been reported to exert cardioprotective effects via various mechanisms. However, whether taurine protects against Hcy-induced cardiomyocyte death by attenuating ER stress is unknown. This study aimed to evaluate the opposite effects of taurine on Hcy-induced cardiomyocyte apoptosis and their underlying mechanisms...
February 22, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27760046/the-long-noncoding-rna-tug1-connects-metabolic-changes-with-kidney-disease-in-podocytes
#8
Szu Yuan Li, Katalin Susztak
An increasing amount of evidence suggests that metabolic alterations play a key role in chronic kidney disease (CKD) pathogenesis. In this issue of the JCI, Long et al. report that the long noncoding RNA (lncRNA) taurine-upregulated 1 (Tug1) contributes to CKD development. The authors show that Tug1 regulates mitochondrial function in podocytes by epigenetic targeting of expression of the transcription factor PPARγ coactivator 1α (PGC-1α, encoded by Ppargc1a). Transgenic overexpression of Tug1 specifically in podocytes ameliorated diabetes-induced CKD in mice...
November 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27527761/the-role-of-ca-2-mediated-signaling-pathways-on-the-effect-of-taurine-against-streptococcus-uberis-infection
#9
Bin Dai, Jinqiu Zhang, Ming Liu, Jinye Lu, Yuanshu Zhang, Yuanyuan Xu, Jinfeng Miao, Yulong Yin
To provide insight into the mechanisms of taurine attenuation of pro-inflammatory response in mouse mammary epithelial cell line (EpH4-Ev, purchased by ATCC, USA) after Streptococcus uberis (S. uberis, 0140J) challenge, we infected MECs with S. uberis (2.5×10(7)cfumL(-1), MOI=10) for 3h and quantified changes in TLR-2 and calcium (Ca(2+)) mediated signaling pathways. The results indicate that S. uberis infection significantly increases the expression of TLR-2, intracellular Ca(2+) levels, PLC-γ1 and PKC-α, the activities of transcription factors NF-κB and NFAT, and related cytokines (TNF-α, IL-1β, IL-6, G-CSF, IL-2, KC, IL-15, FasL, MCP-1, and LIX) in culture supernatants...
August 30, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27322952/activation-of-osmolyte-pathways-in-inflammatory-myopathy-and-duchenne-muscular-dystrophy-points-to-osmoregulation-as-a-contributing-pathogenic-mechanism
#10
Boel De Paepe, Jean-Jacques Martin, Sandrine Herbelet, Cecilia Jimenez-Mallebrera, Estibaliz Iglesias, Cristina Jou, Joachim Weis, Jan L De Bleecker
Alongside well-known nuclear factor κB (NFκB) and its associated cytokine networks, nuclear factor of activated T cells 5 (NFAT5), the master regulator of cellular osmoprotective programs, comes forward as an inflammatory regulator. To gain insight into its yet unexplored role in muscle disease, we studied the expression of NFAT5 target proteins involved in osmolyte accumulation: aldose reductase (AR), taurine transporter (TauT), and sodium myo-inositol co-transporter (SMIT). We analyzed idiopathic inflammatory myopathy and Duchenne muscular dystrophy muscle biopsies and myotubes in culture, using immunohistochemistry, immunofluorescence, and western blotting...
August 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27255599/taurine-pretreatment-prevents-isoflurane-induced-cognitive-impairment-by-inhibiting-er-stress-mediated-activation-of-apoptosis-pathways-in-the-hippocampus-in-aged-rats
#11
Yanan Zhang, Dongliang Li, Haiou Li, Dailiang Hou, Jingdong Hou
Isoflurane, a commonly used inhalation anesthetic, may induce neurocognitive deficits, especially in elderly patients after surgery. Recent study demonstrated that isoflurane caused endoplasmic reticulum (ER) stress and subsequent neuronal apoptosis in the brain, contributing to cognitive deficits. Taurine, a major intracellular free amino acid, has been shown to inhibit ER stress and neuronal apoptosis in several neurological disorders. Here, we examined whether taurine can prevent isoflurane-induced ER stress and cognitive impairment in aged rats...
October 2016: Neurochemical Research
https://www.readbyqxmd.com/read/26856750/characterizing-factors-associated-with-differences-in-fgf19-blood-levels-and-synthesis-in-patients-with-primary-bile-acid-diarrhea
#12
Ian M Johnston, Jonathan D Nolan, Sanjeev S Pattni, Richard N Appleby, Justine H Zhang, Sarah L Kennie, Gaganjit K Madhan, Sina Jameie-Oskooei, Shivani Pathmasrirengam, Jeremy Lin, Albert Hong, Peter H Dixon, Catherine Williamson, Julian R F Walters
OBJECTIVES: Chronic diarrhea caused by primary bile acid diarrhea (PBAD) is a common condition. We have previously shown PBAD is associated with low fasting serum levels of the ileal hormone, fibroblast growth factor 19 (FGF19). FGF19 is a negative regulator of hepatic bile acid synthesis and is stimulated by farnesoid X receptor agonists, which produce symptomatic improvement in PBAD. We aimed to assess possible causes for low serum FGF19 in patients with PBAD. METHODS: Patients with PBAD, defined by reduced (75)Se-labelled homocholic acid taurine (SeHCAT) retention, and idiopathic diarrhea controls had measurements of fasting lipids and fasting/post-prandial FGF19 serum profiles...
March 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/26843082/effects-of-bariatric-surgery-on-serum-bile-acid-composition-and-conjugation-in-a-diabetic-rat-model
#13
Qunzheng Wu, Xiang Zhang, Mingwei Zhong, Haifeng Han, Shaozhuang Liu, Teng Liu, Meng Wei, Wei Guo, Haibin Xie, Sanyuan Hu, Guangyong Zhang
BACKGROUND: Serum bile acids (BAs) are elevated following bariatric surgery and have emerged as a potential glucose-lowering beneficial factor. The change of BA components and its underlying mechanisms may be of great significance during bariatric surgery. The aim of this study is to investigate the effects of different bariatric procedures on serum BA composition and explore the potential mechanisms using a diabetic rat model. METHODS: Duodenal-jejunal bypass (DJB), sleeve gastrectomy (SG), and sham operation were performed in diabetic rats induced by high-fat diet (HFD) and streptozotocin (STZ)...
October 2016: Obesity Surgery
https://www.readbyqxmd.com/read/26573537/deciphering-the-signaling-mechanisms-of-the-plant-cell-wall-degradation-machinery-in-aspergillus-oryzae
#14
D B R K Gupta Udatha, Evangelos Topakas, Margarita Salazar, Lisbeth Olsson, Mikael R Andersen, Gianni Panagiotou
BACKGROUND: The gene expression and secretion of fungal lignocellulolytic enzymes are tightly controlled at the transcription level using independent mechanisms to respond to distinct inducers from plant biomass. An advanced systems-level understanding of transcriptional regulatory networks is required to rationally engineer filamentous fungi for more efficient bioconversion of different types of biomass. RESULTS: In this study we focused on ten chemically defined inducers to drive expression of cellulases, hemicellulases and accessory enzymes in the model filamentous fungus Aspergillus oryzae and shed light on the complex network of transcriptional activators required...
2015: BMC Systems Biology
https://www.readbyqxmd.com/read/26499949/upregulation-of-long-non-coding-rna-tug1-correlates-with-poor-prognosis-and-disease-status-in-osteosarcoma
#15
Bing Ma, Meng Li, Lei Zhang, Ming Huang, Jun-Bin Lei, Gui-Hong Fu, Chun-Xin Liu, Qi-Wen Lai, Qing-Quan Chen, Yi-Lian Wang
The pathogenesis of osteosarcoma involves complex genetic and epigenetic factors. This study was to explore the impact and clinical relevance of long non-coding RNA (lncRNA), Taurine up-regulated gene 1 (TUG1) on patients with osteosarcoma. Seventy-six osteosarcoma tissues and matched adjacent normal tissues were included for analysis. The plasma samples were obtained from 29 patients with osteosarcoma at pre-operation and post-operation, 42 at newly diagnosed, 18 who experienced disease progression or relapse, 45 post-treatment, 36 patients with benign bone tumor, and 20 healthy donors...
April 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/26336870/long-non-coding-rna-tug1-is-up-regulated-in-hepatocellular-carcinoma-and-promotes-cell-growth-and-apoptosis-by-epigenetically-silencing-of-klf2
#16
Ming-De Huang, Wen-Ming Chen, Fu-Zhen Qi, Ming Sun, Tong-Peng Xu, Pei Ma, Yong-Qian Shu
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide, and the biology of this cancer remains poorly understood. Recent evidence indicates that long non-coding RNAs (lncRNAs) are found to be dysregulated in a variety of cancers, including HCC. Taurine Up-regulated Gene 1 (TUG1), a 7.1-kb lncRNA, recruiting and binding to polycomb repressive complex 2 (PRC2), is found to be disregulated in non-small cell lung carcinoma (NSCLC) and esophageal squamous cell carcinoma (ESCC)...
2015: Molecular Cancer
https://www.readbyqxmd.com/read/26192086/endoplasmic-reticulum-stress-as-a-novel-target-to-ameliorate-epithelial-to-mesenchymal-transition-and-apoptosis-of-human-peritoneal-mesothelial-cells
#17
Hyun-Soo Shin, Eun-Sun Ryu, Eok-Soo Oh, Duk-Hee Kang
Epithelial-to-mesenchymal transition (EMT) and apoptosis of peritoneal mesothelial cells are known to be the earliest mechanisms of peritoneal fibrosis in peritoneal dialysis (PD). Endoplasmic reticulum (ER) stress with an unfolded protein response is regarded to have a role in the development of organ fibrosis. To investigate the potential role of ER stress as a target to prevent and/or delay the development of peritoneal fibrosis, we examined the effect of ER stress on EMT or apoptosis of human peritoneal mesothelial cells (HPMCs) and elucidated the mechanisms underlying the protective effect of ER stress preconditioning on TGF-β1-induced EMT...
October 2015: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/26078353/the-long-noncoding-rna-tug1-regulates-blood-tumor-barrier-permeability-by-targeting-mir-144
#18
Heng Cai, Yixue Xue, Ping Wang, Zhenhua Wang, Zhen Li, Yi Hu, Zhiqing Li, Xiuli Shang, Yunhui Liu
Blood-tumor barrier (BTB) limits the delivery of chemotherapeutic agent to brain tumor tissues. Long non-coding RNAs (lncRNAs) have been shown to play critical regulatory roles in various biologic processes of tumors. However, the role of lncRNAs in BTB permeability is unclear. LncRNA TUG1 (taurine upregulated gene 1) was highly expressed in glioma vascular endothelial cells from glioma tissues. It also upregulated in glioma co-cultured endothelial cells (GEC) from BTB model in vitro. Knockdown of TUG1 increased BTB permeability, and meanwhile down-regulated the expression of the tight junction proteins ZO-1, occludin, and claudin-5...
August 14, 2015: Oncotarget
https://www.readbyqxmd.com/read/26022360/comparison-between-single-and-combined-post-treatment-with-s-methyl-n-n-diethylthiolcarbamate-sulfoxide-and-taurine-following-transient-focal-cerebral-ischemia-in-rat-brain
#19
COMPARATIVE STUDY
P Gharibani, J Modi, J Menzie, A Alexandrescu, Z Ma, R Tao, H Prentice, J-Y Wu
We have recently reported on the efficacy of an N-methyl-d-aspartate (NMDA) receptor partial antagonist, S-Methyl-N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO), in improving outcome following stroke, including reduced infarct size and calcium influx, suppressing the endoplasmic reticulum (ER) stress-induced apoptosis as well as improving behavioral outcome. DETC-MeSO was shown to suppress the protein kinase R-like endoplasmic reticulum kinase (PERK) pathway, one of the major ER stress pathways. Several studies including ours have provided evidence that taurine also has neuroprotective effects through reducing apoptosis and inhibiting activating transcription factor 6 (ATF6) and inositol requiring enzyme 1 (IRE-1) pathways...
August 6, 2015: Neuroscience
https://www.readbyqxmd.com/read/25963419/taurine-a-major-amino-acid-of-oyster-enhances-linear-bone-growth-in-a-mouse-model-of-protein-malnutrition
#20
Phil-Dong Moon, Min-Ho Kim, Hun-Sun Lim, Hyun-A Oh, Sun-Young Nam, Na-Ra Han, Myong-Jo Kim, Hyun-Ja Jeong, Hyung-Min Kim
Oysters (Oys) contain various beneficial components, such as, antioxidants and amino acids. However, the effects of Oys or taurine (Tau), a major amino acid in Oys on bone growth have not been determined. In the present study, we evaluated the effects of Oys or Tau on linear bone growth in a mouse model of protein malnutrition. To make the protein malnutrition in a mouse, we used a low protein diet. Growth plate thickness was increased by Oys or Tau. Bone volume/tissue volume, trabecular thickness, trabecular number, connection density, and total porosity were also improved by Oys or Tau...
May 6, 2015: BioFactors
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