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https://www.readbyqxmd.com/read/29333521/nanomaterials-for-convection-enhanced-delivery-of-agents-to-treat-brain-tumors
#1
Young-Eun Seo, Tom Bu, W Mark Saltzman
Nanomaterials represent a promising and versatile platform for the delivery of therapeutics to the brain. Treatment of brain tumors has been a long-standing challenge in the field of neuro-oncology. The current standard of care - a multimodal approach of surgery, radiation and chemotherapy - yields only a modest therapeutic benefit for patients with malignant gliomas. A major obstacle for treatment is the failure to achieve sufficient delivery of therapeutics at the tumor site. Recent advances in local drug delivery techniques, along with the development of highly effective brain-penetrating nanocarriers, have significantly improved treatment and imaging of brain tumors in preclinical studies...
December 2017: Current Opinion in Biomedical Engineering
https://www.readbyqxmd.com/read/29332052/when-art-meets-gardens-does-it-enhance-the-benefits-the-nancy-hypothesis-of-care-for-persons-with-alzheimer-s-disease
#2
Thérèse Rivasseau Jonveaux, Reinhard Fescharek
The creation of healing gardens for persons with Alzheimer's disease and related diseases (ADRD) offers vast potential. They can play a role in the scaffolding of cognitive disorders, emotional stress, sensory processing, sense of harmony, and appeasement. These effects are achieved through a distributed interplay of psychological functions with the immediate environment and local culture on the one hand, and dialogue on the other. The garden, a natural canvas created by man, shares with art the ability to foster an esthetic sense for which the perception can be measured by functional neurological imaging exploration...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29325389/-development-of-en-face-optical-coherence-tomography-and-its-application-in-ocular-fundus-diseases
#3
Y Zhou, M Wang
Optical coherence tomography (OCT) is able to obtain the cross-sectional image of the fundus noninvasively and quickly. The cross-sectional image in vivo almost matches the histological section of the retina. OCT has become the most important imaging tool in ophthalmology. Based on the latest OCT technology, en face OCT is a new imaging technique that reveals the structure of retinal and choroidal sections approximately paralleled to the retina surface. Compared to the conventional OCT, en face OCT provides more comprehensive information and makes more accurate diagnosis and assessment of the prognosis...
December 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29323138/whole-mount-adult-ear-skin-imaging-reveals-defective-neuro-vascular-branching-morphogenesis-in-obese-and-type-2-diabetic-mouse-models
#4
Tomoko Yamazaki, Wenling Li, Ling Yang, Ping Li, Haiming Cao, Sei-Ichiro Motegi, Mark C Udey, Elise Bernhard, Takahisa Nakamura, Yoh-Suke Mukouyama
Obesity and type 2 diabetes are frequently associated with peripheral neuropathy. Though there are multiple methods for diagnosis and analysis of morphological changes of peripheral nerves and blood vessels, three-dimensional high-resolution imaging is necessary to appreciate the pathogenesis with an anatomically recognizable branching morphogenesis and patterning. Here we established a novel technique for whole-mount imaging of adult mouse ear skin to visualize branching morphogenesis and patterning of peripheral nerves and blood vessels...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317311/concomitant-use-of-mesenchymal-stem-cells-and-neural-stem-cells-for-treatment-of-spinal-cord-injury-a-combo-cell-therapy-approach
#5
Seyed Mojtaba Hosseini, Mahsa Sani, Kh Husnanin Haider, Mohammadreza Dorvash, Seyyed Mohyeddin Ziaee, Aliasghar Karimi, Mohmmad Reza Namavar
with neural stem cells (NSCs) provides a hope to recover the neural damage and compensate for the lost neural structures for restoration of interrupted neural communications above and below the site of injury. However, cell-based therapy approach suffers from many biological barriers and technical caveats which severely hamper the prognosis. The biochemically-rich microenvironment at the site of spinal cord injury (SCI), the continuing neuro-degenerative process and infiltrating immune cells offer a serious barrier to the donor cells...
January 6, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29316820/cost-effectiveness-of-access-to-critical-cerebral-emergency-support-services-access-a-neuro-emergent-telemedicine-consultation-program
#6
Justin Whetten, David N van der Goes, Huy Tran, Mark Moffett, Colin Semper, Howard Yonas
AIMS: Access to Critical Cerebral Emergency Support Services (ACCESS) was developed as a low-cost solution to providing neuro-emergent consultations to rural hospitals in New Mexico that do not offer comprehensive stroke care. ACCESS is a two-way audio visual program linking remote emergency department physicians and their patients to stroke specialists. ACCESS also has an education component in which hospitals receive training from stroke specialists on the triage and treatment of patients...
January 9, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29311540/diffusion-tensor-imaging-in-diagnosis-of-post-traumatic-syringomyelia-in-spinal-cord-injury-in-rats
#7
Chao Zhang, Kai Chen, Xiuxin Han, Jiayuanyuan Fu, Patricia Douglas, Anna Y Morozova, Maxim A Abakumov, Ilya L Gubsky, Dejin Li, Jin Guo, Xuening Zhang, Guowen Wang, Vladimir P Chekhonin
BACKGROUND Post-traumatic syringomyelia (PTS) is a common disease after spinal cord injury (SCI). The present study was performed to evaluate the advantages of diffusion tensor imaging (DTI) in estimating SCI and prognosing PTS in SCI rats. MATERIAL AND METHODS Forty rats were divided into 3 groups based on the extent of the individual SCI and PTS: a control group (n=10), a PTS group (n=8), and an SCI group (n=22). BBB tests were performed preoperatively and postoperatively at (1 d, 3 d, 5 d, 1 w, 2 w, 1 w, 2 w, 3 w, 4 w, 5 w, and 6 w)...
January 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29303386/visual-prognosis-in-compressive-optic-neuropathy-secondary-to-sphenoid-sinus-mucocele-a-systematic-review
#8
Emily Li, Martha A Howard, Eugenia M Vining, Richard D Becker, Jonathan Silbert, Robert L Lesser
Sphenoid sinus mucoceles (SSMs) are rare, benign lesions that can expand, often presenting with ocular symptoms-decreased vision, diplopia, visual field defects, proptosis, and external ophthalmoplegia. Reported cases are few, visual compromise varies, and factors affecting visual prognosis are poorly characterized. We investigate whether prompt surgical intervention (within 2 weeks of visual symptom onset) affects best-corrected visual acuity (BCVA) regained in patients with vision loss secondary to compressive SSM...
January 5, 2018: Orbit
https://www.readbyqxmd.com/read/29299506/longitudinal-up-regulation-of-endolymphatic-hydrops-in-patients-with-meniere-s-disease-during-medical-treatment
#9
Munehisa Fukushima, Tadashi Kitahara, Ryohei Oya, Shiro Akahani, Hidenori Inohara, Shinji Naganawa, Noriaki Takeda
Objective/Hypothesis: Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments. Study Design: Prospective, single-arm repeated measures. Methods: Eleven MD patients were enrolled...
December 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29295569/extent-of-resection-in-newly-diagnosed-glioblastoma-impact-of-a-specialized-neuro-oncology-care-center
#10
Amer Haj, Christian Doenitz, Karl-Michael Schebesch, Denise Ehrensberger, Peter Hau, Kurt Putnik, Markus J Riemenschneider, Christina Wendl, Michael Gerken, Tobias Pukrop, Alexander Brawanski, Martin A Proescholdt
Treatment of glioblastoma (GBM) consists of microsurgical resection followed by concomitant radiochemotherapy and adjuvant chemotherapy. The best outcome regarding progression free (PFS) and overall survival (OS) is achieved by maximal resection. The foundation of a specialized neuro-oncology care center (NOC) has enabled the implementation of a large technical portfolio including functional imaging, awake craniotomy, PET scanning, fluorescence-guided resection, and integrated postsurgical therapy. This study analyzed whether the technically improved neurosurgical treatment structure yields a higher rate of complete resection, thus ultimately improving patient outcome...
December 25, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29290461/oculomotor-palsy-in-diabetics
#11
H Lajmi, W Hmaied, W Ben Jalel, Z Chelly, A Ben Yakhlef, F Ben Zineb, L El Fekih
INTRODUCTION: Oculomotor palsy is one of the most frequent neuro-ophthalmologic complications of diabetic patients. It generates less interest in the literature than the other ocular manifestations. Our goal was to study the clinical, epidemiological, therapeutic and prognostic characteristics of oculomotor palsy in the diabetic. METHODS: This is a retrospective study of 24 diabetic patients with oculomotor palsy. The ophthalmological examination emphasized ocular motility...
December 28, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29288841/management-of-severe-traumatic-brain-injury-first-24-hours
#12
Thomas Geeraerts, Lionel Velly, Lamine Abdennour, Karim Asehnoune, Gérard Audibert, Pierre Bouzat, Nicolas Bruder, Romain Carrillon, Vincent Cottenceau, François Cotton, Sonia Courtil-Teyssedre, Claire Dahyot-Fizelier, Frédéric Dailler, Jean-Stéphane David, Nicolas Engrand, Dominique Fletcher, Gilles Francony, Laurent Gergelé, Carole Ichai, Etienne Javouhey, Pierre-Etienne Leblanc, Thomas Lieutaud, Philippe Meyer, Sébastien Mirek, Gilles Orliaguet, François Proust, Hervé Quintard, Catherine Ract, Mohamed Srairi, Karim Tazarourte, Bernard Vigué, Jean-François Payen
The latest French Guidelines for the management in the first 24hours of patients with severe traumatic brain injury (TBI) were published in 1998. Due to recent changes (intracerebral monitoring, cerebral perfusion pressure management, treatment of raised intracranial pressure), an update was required. Our objective has been to specify the significant developments since 1998. These guidelines were conducted by a group of experts for the French Society of Anesthesia and Intensive Care Medicine (Société Francaise d'Anesthésie Réanimation (SFAR)) in partnership with the Association de Neuro-Anesthésie-Réanimation de Langue Française (ANARLF), the Société Française de Neurochirurgie (SFN), the Groupe Francophone de Réanimation et d'Urgences Pédiatriques (GFRUP) and the Association des Anesthésistes-Réanimateurs Pédiatriques d'Expression Française (ADARPEF)...
December 27, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29286948/a-profile-of-neuro-ophthalmic-practice-around-the-world
#13
Larry P Frohman
BACKGROUND: To compare contrast neuro-ophthalmic practice in various countries, an 18-question survey was sent to the international North American Neuro-Ophthalmology Society (NANOS) members in the spring of 2016. METHODS: At least 1 NANOS member was contacted for each non-US nation in the NANOS membership roster. If there were multiple NANOS members from 1 country, multiple were contacted. If responses were received from more than 1 person from a single country, the first response received was used as the source data...
December 27, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29283100/the-efficacy-of-magnetic-resonance-imaging-for-the-diagnosis-of-superior-semicircular-canal-dehiscence
#14
Fatma Beyazal Çeliker, Abdulkadir Özgür, Metin Çeliker, Mehmet Beyazal, Arzu Turan, Suat Terzi, Mehmet Fatih İnecikli
OBJECTIVE: This study aimed to evaluate the efficacy of magnetic resonance imaging (MRI) for diagnosing superior semicircular canal dehiscence (SSCD). MATERIALS AND METHODS: The radiological records of patients who were admitted to our clinic with complaints of otologic and neuro-otologic symptoms between October 2014 and December 2015 were retrospectively reviewed. Among these patients, those who underwent both computed tomography and MRI and were reported to have SSCD in the temporal bone on at least one side were included in the study group...
December 14, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29282579/accuracy-of-outside-radiologists-reports-of-computed-tomography-exams-of-emergently-transferred-patients
#15
Jeffrey D Robinson, Ken F Linnau, Daniel S Hippe, Kellie L Sheehan, Joel A Gross
PURPOSE: Growing numbers of patient with advanced imaging being transferred to trauma centers has resulted in increased numbers of outside CT scans received at trauma centers. This study examines the degree of agreement between community radiologists' interpretations of the CT scans of transferred patients and trauma center radiologists' reinterpretation. METHODS: All CT scans of emergency transfer patients received over a 1 month period were reviewed by an emergency radiologist...
December 27, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/29282517/11c-met-pet-mri-for-detection-of-recurrent-glioma
#16
C Deuschl, J Kirchner, T D Poeppel, B Schaarschmidt, S Kebir, N El Hindy, J Hense, H H Quick, M Glas, K Herrmann, L Umutlu, C Moenninghoff, A Radbruch, M Forsting, M Schlamann
INTRODUCTION: Radiological assessment of brain tumors is widely based on the Radiology Assessment of Neuro-Oncology (RANO) criteria that consider non-specific T1 and T2 weighted images. Limitation of the RANO criteria is that they do not include metabolic imaging techniques that have been reported to be helpful to differentiate treatment related changes from true tumor progression. In the current study, we assessed if the combined use of MRI and PET with hybrid 11C-MET PET/MRI can improve diagnostic accuracy and diagnostic confidence of the readers to differentiate treatment related changes from true progression in recurrent glioma...
December 28, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29273948/icp-curve-morphology-and-intracranial-flow-volume-changes-a-simultaneous-icp-and-cine-phase-contrast-mri-study-in-humans
#17
Mårten Unnerbäck, Johnny T Ottesen, Peter Reinstrup
BACKGROUND: The intracranial pressure (ICP) curve with its different peaks has been extensively studied, but the exact physiological mechanisms behind its morphology are still not fully understood. Both intracranial volume change (ΔICV) and transmission of the arterial blood pressure have been proposed to shape the ICP curve. This study tested the hypothesis that the ICP curve correlates to intracranial volume changes. METHODS: Cine phase contrast magnetic resonance imaging (MRI) examinations were performed in neuro-intensive care patients with simultaneous ICP monitoring...
December 22, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29260585/intraoperative-visualisation-of-functional-structures-facilitates-safe-frameless-stereotactic-biopsy-in-the-motor-eloquent-regions-of-the-brain
#18
Jia-Shu Zhang, Ling Qu, Qun Wang, Wei Jin, Yuan-Zheng Hou, Guo-Chen Sun, Fang-Ye Li, Xin-Guang Yu, Ban-Nan Xu, Xiao-Lei Chen
BACKGROUND: For stereotactic brain biopsy involving motor eloquent regions, the surgical objective is to enhance diagnostic yield and preserve neurological function. To achieve this aim, we implemented functional neuro-navigation and intraoperative magnetic resonance imaging (iMRI) into the biopsy procedure. The impact of this integrated technique on the surgical outcome and postoperative neurological function was investigated and evaluated. METHOD: Thirty nine patients with lesions involving motor eloquent structures underwent frameless stereotactic biopsy assisted by functional neuro-navigation and iMRI...
December 20, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29260032/longitudinal-clinical-and-neuro-radiological-findings-in-a-patient-with-leukoencephalopathy-with-brain-calcifications-and-cysts-labrune-syndrome
#19
Yasushi Iwasaki, Ken-Ichiro Hoshino, Keiko Mori, Masumi Ito, Yoshinari Kawai, Maya Mimuro, Tamao Tsukie, Takeshi Ikeuchi, Mari Yoshida
Since she was 4 years old, the patient had exhibited frequent convulsive seizures, and she experienced severe headaches and depression in adulthood. At the age of 37 years, cerebral calcifications were detected, but she exhibited no cognitive or motor problems. She suffered a cerebral haemorrhage at 49 years old and experienced cognitive dysfunction, dysarthria, dysphagia, and left-hemiparesis as sequelae. After undergoing gastrostomy, she exhibited very slow cognitive deterioration associated with speech disturbance over more than 10 years...
September 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29251592/the-role-of-microglia-and-their-cx3cr1-signaling-in-adult-neurogenesis-in-the-olfactory-bulb
#20
Ronen Reshef, Elena Kudryavitskaya, Haran Shani-Narkiss, Batya Isaacson, Neta Rimmerman, Adi Mizrahi, Raz Yirmiya
Microglia play important roles in perinatal neuro- and synapto-genesis. To test the role of microglia in these processes during adulthood, we examined the effects of microglia depletion, via treatment of mice with the CSF-1 receptor antagonist PLX5622, and abrogated neuronal-microglial communication in CX3C receptor-1 deficient (Cx3cr1-/-) mice. Microglia depletion significantly lowered spine density in young (developing) but not mature adult-born-granule-cells (abGCs) in the olfactory bulb. Two-photon time-lapse imaging indicated that microglia depletion reduced spine formation and elimination...
December 18, 2017: ELife
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