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https://www.readbyqxmd.com/read/29140767/genomic-medicine-without-borders-which-strategies-should-developing-countries-employ-to-invest-in-precision-medicine-a-new-fast-second-winner-strategy
#1
Konstantinos Mitropoulos, David N Cooper, Christina Mitropoulou, Spiros Agathos, Jürgen K V Reichardt, Fatima Al-Maskari, Wasun Chantratita, Ambroise Wonkam, Collet Dandara, Theodora Katsila, Catalina Lopez-Correa, Bassam R Ali, George P Patrinos
Genomic medicine has greatly matured in terms of its technical capabilities, but the diffusion of genomic innovations worldwide faces significant barriers beyond mere access to technology. New global development strategies are sorely needed for biotechnologies such as genomics and their applications toward precision medicine without borders. Moreover, diffusion of genomic medicine globally cannot adhere to a "one-size-fits-all-countries" development strategy, in the same way that drug treatments should be customized...
November 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29130757/international-barcode-of-life-focus-on-big-biodiversity-in-south-africa
#2
Sarah J Adamowicz, Peter M Hollingsworth, Sujeevan Ratnasingham, Michelle van der Bank
Participants in the 7th International Barcode of Life Conference (Kruger National Park, South Africa, 20-24 November 2017) share the latest findings in DNA barcoding research and its increasingly diversified applications. Here, we review prevailing trends synthesized from among 429 invited and contributed abstracts, which are collated in this open-access special issue of Genome. Hosted for the first time on the African continent, the 7th Conference places special emphasis on the evolutionary origins, biogeography, and conservation of African flora and fauna...
November 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/29127232/epidemiology-of-hypertension-in-northern-tanzania-a-community-based-mixed-methods-study
#3
Sophie W Galson, Catherine A Staton, Francis Karia, Kajiru Kilonzo, Joseph Lunyera, Uptal D Patel, Julian T Hertz, John W Stanifer
INTRODUCTION: Sub-Saharan Africa is particularly vulnerable to the growing global burden of hypertension, but epidemiological studies are limited and barriers to optimal management are poorly understood. Therefore, we undertook a community-based mixed-methods study in Tanzania to investigate the epidemiology of hypertension and barriers to care. METHODS: In Northern Tanzania, between December 2013 and June 2015, we conducted a mixed-methods study, including a cross-sectional household epidemiological survey and qualitative sessions of focus groups and in-depth interviews...
November 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/29121051/process-evaluation-of-knowledge-transfer-across-industries-leveraging-coca-cola-s-supply-chain-expertise-for-medicine-availability-in-tanzania
#4
Erika Linnander, Christina T Yuan, Shirin Ahmed, Emily Cherlin, Kristina Talbert-Slagle, Leslie A Curry
Persistent gaps in the availability of essential medicines have slowed the achievement of global health targets. Despite the supply chain knowledge and expertise that ministries of health might glean from other industries, limited empirical research has examined the process of knowledge transfer from other industries into global public health. We examined a partnership designed to improve the availability of medical supplies in Tanzania by transferring knowledge from The Coca-Cola system to Tanzania's Medical Stores Department (MSD)...
2017: PloS One
https://www.readbyqxmd.com/read/29119870/current-and-emerging-global-themes-in-the-bioethics-of-regenerative-medicine-the-tangled-web-of-stem-cell-translation
#5
Sarah Chan
Probably the most serious problem facing the field of regenerative medicine today is the challenge of effective translation and development of viable stem cell-based therapies. Particular concerns have been raised over the growing market in unproven cell therapies. In this article, I explore recent developments in the stem cell therapy landscape and argue that while the sale of unproven therapies undoubtedly poses ethical concerns, it must be understood as part of a larger problem at the interface between biomedicine, healthcare, publics, policy and the market...
October 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/29118777/capparis-spinosa-l-in-a-systematic-review-a-xerophilous-species-of-multi-values-and-promising-potentialities-for-agrosystems-under-the-threat-of-global-warming
#6
REVIEW
Stephanie Chedraoui, Alain Abi-Rizk, Marc El-Beyrouthy, Lamis Chalak, Naim Ouaini, Loïc Rajjou
Caper (Capparis spinosa L.) is a xerophytic shrub with a remarkable adaptability to harsh environments. This plant species is of great interest for its medicinal/pharmacological properties and its culinary uses. Its phytochemical importance relies on many bioactive components present in different organs and its cultivation can be of considerable economic value. Moreover, taxonomic identification of C. spinosa L. has been difficult due to its wide heterogeneity, and many authors fell into confusion due to the scarcity of genetic studies...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29114341/tackling-challenges-of-global-health-electives-resident-experiences-of-a-structured-and-supervised-medicine-elective-within-an-existing-global-health-partnership
#7
Michelle Tubman, James Maskalyk, David Mackinnon, Raghu Venugopal, Elayna Fremes, Lisa M Puchalski Ritchie, Aklilu Azazh, Megan Landes
Background: The Toronto-Addis Ababa Academic Collaboration in Emergency Medicine (TAAAC-EM) deploys teaching teams of Canadian EM faculty to Addis Ababa to deliver a longitudinal residency curriculum. Canadian trainees participate in these teams as a formally structured and supervised elective in global health (GH) and EM, which has been designed to enhance the strength of GH electives and address key challenges highlighted in the literature. Methods: The purpose of this qualitative study was to identify, describe, and evaluate strengths and weaknesses of this elective in relation to its purposeful structure...
April 2017: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/29110977/clinical-mimics-an-emergency-medicine-focused-review-of-syncope-mimics
#8
Diana K Coleman, Brit Long, Alex Koyfman
BACKGROUND: Syncope is an event that causes a transient loss of consciousness (LOC) secondary to global cerebral hypoperfusion. The transient nature of the event can make diagnosis in the emergency department (ED) difficult, as symptoms have often resolved by time of initial presentation. The symptoms and presentation of syncope are similar to many other conditions, which can lead to difficulty in establishing a diagnosis in the ED. OBJECTIVE: This review evaluates patients presenting with a history concerning for possible syncope, mimics of syncope, and approach to managing syncope mimics...
October 27, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29110756/apol1-nephropathy-a-population-genetics-and-evolutionary-medicine-detective-story
#9
REVIEW
Etty Kruzel-Davila, Walter G Wasser, Karl Skorecki
Common DNA sequence variants rarely have a high-risk association with a common disease. When such associations do occur, evolutionary forces must be sought, such as in the association of apolipoprotein L1 (APOL1) gene risk variants with nondiabetic kidney diseases in populations of African ancestry. The variants originated in West Africa and provided pathogenic resistance in the heterozygous state that led to high allele frequencies owing to an adaptive evolutionary selective sweep. However, the homozygous state is disadvantageous and is associated with a markedly increased risk of a spectrum of kidney diseases encompassing hypertension-attributed kidney disease, focal segmental glomerulosclerosis, human immunodeficiency virus nephropathy, sickle cell nephropathy, and progressive lupus nephritis...
November 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/29093380/a-retrospective-single-center-analysis-of-16-cases-of-imported-chikungunya-fever-in-japan
#10
Satoshi Kutsuna, Yasuyuki Kato, Yuichi Katanami, Kei Yamamoto, Nozomi Takeshita, Kayoko Hayakawa, Shuzo Kanagawa, Norio Ohmagari
Background Chikungunya fever (CHIK) is a re-emerging arboviral disease that is transmitted through the bite of infected Aedes mosquitoes. There is limited information regarding the epidemiology and clinical information of imported CHIK in Japan. Objective The objective of this study was to review the epidemiology and clinical information of imported CHIK patients treated at the National Center for Global Health and Medicine (NCGM). Methods We evaluated all patients (n=16) who were diagnosed with imported CHIK and treated at the NCGM between October 1, 2005 and March 31, 2016...
November 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29081822/southeast-asian-medicinal-plants-as-a-potential-source-of-antituberculosis-agent
#11
REVIEW
Shuaibu Babaji Sanusi, Mohd Fadzelly Abu Bakar, Maryati Mohamed, Siti Fatimah Sabran, Muhammad Murtala Mainasara
Despite all of the control strategies, tuberculosis (TB) is still a major cause of death globally and one-third of the world's population is infected with TB. The drugs used for TB treatment have drawbacks of causing adverse side effects and emergence of resistance strains. Plant-derived medicines have since been used in traditional medical system for the treatment of numerous ailments worldwide. There were nine major review publications on antimycobacteria from plants in the last 17 years. However, none is focused on Southeast Asian medicinal plants...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29025526/hospital-acquired-urinary-tract-infections-results-of-a-cohort-study-performed-in-an-internal-medicine-department
#12
Maria João Lobão, Paulo Sousa
INTRODUCTION: Urinary tract infections are the most frequent healthcare associated infections, being related to both high costs and morbidity. Our intention was to carry out an epidemiological characterization of hospital acquired urinary tract infections that occurred in an internal medicine department of a Portuguese hospital. MATERIAL AND METHODS: Retrospective cohort study (historic cohort). Data were analysed from a systematic random sample of 388 patients, representative of the 3492 admissions occurred in 2014 in that department...
September 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29016534/analysis-of-the-citation-of-articles-published-in-the-european-journal-of-emergency-medicine-since-its-foundation
#13
Inés M Fernández-Guerrero, Francisco J Martín-Sánchez, Guillermo Burillo-Putze, Collin A Graham, Òscar Miró
OBJECTIVES: The aim of this study was to evaluate the evolution of the citation of articles from the European Journal of Emergency Medicine (EJEM) from 1994 (EJEM foundation) to 2015 and identify highly cited articles and their principal characteristics and determine a possible correlation between the citations counted in different databases. MATERIALS AND METHODS: We obtained the articles published in EJEM from 1994 to 2015 in ISI-WoS (main source) and Scopus, Google Scholar, and Medline databases (accessory sources)...
October 9, 2017: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/28992873/the-rapid-disaster-evaluation-system-rades-a-plan-to-improve-global-disaster-response-by-privatizing-the-assessment-component
#14
Kenneth V Iserson
BACKGROUND: Emergency medicine personnel frequently respond to major disasters. They expect to have an effective and efficient management system to elegantly allocate available resources. Despite claims to the contrary, experience demonstrates this rarely occurs. OBJECTIVES: This article describes privatizing disaster assessment using a single-purposed, accountable, and well-trained organization. The goal is to achieve elegant disaster assessment, rather than repeatedly exhorting existing groups to do it...
September 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28992388/impact-of-nutrition-interventions-on-pediatric-mortality-and-nutrition-outcomes-in-humanitarian-emergencies
#15
REVIEW
Kamna S Balhara, David M Silvestri, W Tyler Winders, Anand Selvam, Sean M Kivlehan, Torben K Becker, Adam C Levine
OBJECTIVES: Malnutrition contributes to pediatric morbidity and mortality in disasters and complex emergencies, but summary data describing specific nutritional interventions in these settings are lacking. This systematic review aims to characterize such interventions and their effects on pediatric mortality, anthropometric measures, and serum markers of nutrition. METHODS: A systematic search of OVID Medline, Cochrane Library, and relevant grey literature was conducted...
October 9, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28986822/global-spread-of-hemorrhagic-fever-viruses-predicting-pandemics
#16
Jean-Paul Gonzalez, Marc Souris, Willy Valdivia-Granda
As successive epidemics have swept the world, the scientific community has quickly learned from them about the emergence and transmission of communicable diseases. Epidemics usually occur when health systems are unprepared. During an unexpected epidemic, health authorities engage in damage control, fear drives action, and the desire to understand the threat is greatest. As humanity recovers, policy-makers seek scientific expertise to improve their "preparedness" to face future events.Global spread of disease is exemplified by the spread of yellow fever from Africa to the Americas, by the spread of dengue fever through transcontinental migration of mosquitos, by the relentless influenza virus pandemics, and, most recently, by the unexpected emergence of Ebola virus, spread by motorbike and long haul carriers...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28981463/restructuring-the-production-of-medicines-an-investigation-on-the-pharmaceutical-sector-in-china-and-the-role-of-mergers-and-acquisitions
#17
Elisa Barbieri, Manli Huang, Shenglei Pi, Mattia Tassinari
In places like China, an ageing population coupled with changes in living standards and increases in disposable income, imply a shift of the demand for health-related goods and services which is likely to affect the whole organization of the industries that supply such goods and services at the global level. One of the industries most likely to be affected is the pharmaceutical sector. In the early 2000s China was already the second largest global producer of pharmaceutical ingredients. The pharmaceutical sector has become one of the most important industries promoted by the Chinese government and Five-Year Plan of China's Strategic Emerging Sectors, mergers and acquisition (M&A) activity has been the key strategy to restructure the sector and increase its competitiveness...
October 5, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28980008/challenges-and-barriers-for-implementation-of-the-world-health-organization-global-disability-action-plan-in-low-and-middle-income-countries
#18
Fary Khan, Mayowa Ojo Owolabi, Bhasker Amatya, Talhatu Kolapo Hamzat, Adesola Ogunniyi, Helen Oshinowo, Alaeldin Elmalik, Mary P Galea
OBJECTIVE: To identify potential barriers and facilitators for implementation of the World Health Organization Global Disability Action Plan (GDAP) in Nigeria and compare these with other low- and middle-income countries. METHODS: A rehabilitation team from the Royal Melbourne Hospital, Parkville, Australia, conducted intensive workshops at medical/academic institutions in Nigeria for healthcare professionals from various local Physical Medicine and Rehabilitation facilities...
October 5, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28972551/sophoraflavenone-g-restricts-dengue-and-zika-virus-infection-via-rna-polymerase-interference
#19
Alexandre Sze, David Olagnier, Samar Bel Hadj, Xiaoying Han, Xiao Hong Tian, Hong-Tao Xu, Long Yang, Qingwen Shi, Penghua Wang, Mark A Wainberg, Jian Hui Wu, Rongtuan Lin
Flaviviruses including Zika, Dengue and Hepatitis C virus cause debilitating diseases in humans, and the former are emerging as global health concerns with no antiviral treatments. We investigated Sophora Flavecens, used in Chinese medicine, as a source for antiviral compounds. We isolated Sophoraflavenone G and found that it inhibited Hepatitis C replication, but not Sendai or Vesicular Stomatitis Virus. Pre- and post-infection treatments demonstrated anti-flaviviral activity against Dengue and Zika virus, via viral RNA polymerase inhibition...
October 3, 2017: Viruses
https://www.readbyqxmd.com/read/28969442/psychiatric-genomics-an-update-and-an-agenda
#20
Patrick F Sullivan, Arpana Agrawal, Cynthia M Bulik, Ole A Andreassen, Anders D Børglum, Gerome Breen, Sven Cichon, Howard J Edenberg, Stephen V Faraone, Joel Gelernter, Carol A Mathews, Caroline M Nievergelt, Jordan W Smoller, Michael C O'Donovan
The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of psychiatry. This global effort is dedicated to rapid progress and open science, and in the past decade it has delivered an increasing flow of new knowledge about the fundamental basis of common psychiatric disorders. The PGC has recently commenced a program of research designed to deliver "actionable" findings-genomic results that 1) reveal fundamental biology, 2) inform clinical practice, and 3) deliver new therapeutic targets...
October 3, 2017: American Journal of Psychiatry
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