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https://www.readbyqxmd.com/read/29773744/worldwide-emergence-of-resistance-to-antifungal-drugs-challenges-human-health-and-food-security
#1
REVIEW
Matthew C Fisher, Nichola J Hawkins, Dominique Sanglard, Sarah J Gurr
The recent rate of emergence of pathogenic fungi that are resistant to the limited number of commonly used antifungal agents is unprecedented. The azoles, for example, are used not only for human and animal health care and crop protection but also in antifouling coatings and timber preservation. The ubiquity and multiple uses of azoles have hastened the independent evolution of resistance in many environments. One consequence is an increasing risk in human health care from naturally occurring opportunistic fungal pathogens that have acquired resistance to this broad class of chemicals...
May 18, 2018: Science
https://www.readbyqxmd.com/read/29765871/optimizing-medicine-use-for-people-who-are-homebound-an-evaluation-of-a-pilot-domiciliary-medicine-use-review-dmur-service-in-england
#2
Asam Latif, Baguiasri Mandane, Emma Anderson, Caroline Barraclough, Samantha Travis
Background: As global life expectancy increases, older people with chronic diseases are being required to manage multiple and complex medicine regimes. However, polypharmacy raises the risk of medicine-related problems and preventable hospital admissions. To improve medicine use, English community pharmacies are commissioned to deliver Medicines Use Reviews (MURs), which are typically delivered from the pharmacy. People who are homebound rarely receive the service. This paper describes the uptake and impact of a pilot project that seeks to provide domiciliary Medicines Use Reviews (dMURs)...
2018: Integrated Pharmacy Research and Practice
https://www.readbyqxmd.com/read/29764209/next-gen-therapeutics-for-skin-cancer-nutraceuticals
#3
Annapoorna Sreedhar, Jun Li, Yunfeng Zhao
Growing modernization and lifestyle changes with limited physical activity have impacted diet and health, leading to an increased cancer mortality rate worldwide. As a result, there is a greater need than before to develop safe and novel anticancer drugs. Current treatment options such as chemotherapy, radiotherapy and surgery, induce unintended side effects, compromising patient's quality of life, and physical well-being. Therefore, there has been an increased global interest in the use of dietary supplements and traditional herbal medicines for treatment of cancer...
May 15, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29760862/free-open-access-medical-education-foam-in-emergency-medicine-the-global-distribution-of-users-in-2016
#4
Taylor W Burkholder, Jennifer W Bellows, Renee A King
Introduction: Free open-access medical education (FOAM) is a collection of interactive online medical education resources-free and accessible to students, physicians and other learners. This novel approach to medical education has the potential to reach learners across the globe; however, the extent of its global uptake is unknown. Methods: This descriptive report evaluates the 2016 web analytics data from a convenience sample of FOAM blogs and websites with a focus on emergency medicine (EM) and critical care...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29751123/high-altitude-species-high-profits-can-the-trade-in-wild-harvested-fritillaria-cirrhosa-liliaceae-be-sustained
#5
REVIEW
A B Cunningham, J A Brinckmann, S-J Pei, P Luo, U Schippmann, X Long, Y-F Bi
ETHNOPHARMACOLOGICAL RELEVANCE: Fritillaria cirrhosa D. Don bulbs contain alkaloids and are one of the most intensively exploited alpine Himalayan medicinal species. In terms of proprietary medicines, our study shows that 210 F. cirrhosa products are offered by 46 suppliers, most of which (44) are situated in China and two in Nepal. A widepread commercial use is as one of the main ingredients in cough syrups. A well known example is "Nin Jiom Pei Pa Koa Herbal Cough & Throat Syrup", which typically contains more F...
May 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29749834/enabling-personalized-medicine-in-europe-by-the-european-commission-s-funding-activities
#6
Elmar Nimmesgern, Irene Norstedt, Ruxandra Draghia-Akli
Personalized medicine (PM) is an emerging approach to prevention, diagnosis, treatment and care. It helps to address the challenge of the aging of the population, an increase in chronic disease and increasing healthcare costs. The EU is developing policies to move toward PM. This is underpinned by a sustained and significant investment starting in 2010. So far, a total of €3.2 billion has been invested in PM research across the medical innovation cycle 'from bench to bedside'. This investment has come from the research framework programs FP7 and Horizon 2020...
July 2017: Personalized Medicine
https://www.readbyqxmd.com/read/29738295/antibiotic-resistance-and-biofilm-tolerance-a-combined-threat-in-the-treatment-of-chronic-infections
#7
Philip G Bowler
Since the introduction of antibiotics into human medicine in the 1940's, antibiotic resistance has emerged at an alarming rate and is now a major threat to public health. This problem is amplified by pathogenic bacteria existing most commonly in biofilm form, creating additional bacterial tolerance to antimicrobial agents. Biofilm is now considered to be a primary cause of chronic infection, and antibiotic-resistant bacteria are prevalent in biofilm form. In particular, chronic non-healing wounds commonly harbour complex polymicrobial, pathogenic biofilm that is tolerant to systemic and topical antimicrobial therapy...
May 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29736939/effects-of-silymarin-on-the-metabolic-syndrome-a-review
#8
REVIEW
Maryam Vahabzadeh, Nafise Amiri, Gholamreza Karimi
BACKGROUND: The metabolic syndrome is one of the rising global health problems and medical challenges due to several clinical complications it may cause, for example increasing the risk of myocardial infarction and hypertension. On the other hand, great attention has been directed toward determining the worthiness of herbal medicines. There are emerging studies on preventive and therapeutic effects of silymarin on different components of the metabolic syndrome. Extracted from the dried seeds of milk thistle plant (Silybum marianum L...
May 7, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29736177/propolis-and-its-potential-to-treat-gastrointestinal-disorders
#9
REVIEW
Luisa Mota da Silva, Priscila de Souza, Soad K Al Jaouni, Steve Harakeh, Shahram Golbabapour, Sérgio Faloni de Andrade
There are a number of disorders that affect the gastrointestinal tract. Such disorders have become a global emerging disease with a high incidence and prevalence rates worldwide. Inflammatory and ulcerative processes of the stomach or intestines, such as gastritis, ulcers, colitis, and mucositis, afflict a significant proportion of people throughout the world. The role of herbal-derived medicines has been extensively explored in order to develop new effective and safe strategies to improve the available gastrointestinal therapies that are currently used in the clinical practice...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29686487/global-governance-mechanisms-to-address-antimicrobial-resistance
#10
Ponnu Padiyara, Hajime Inoue, Marc Sprenger
Since their discovery, antibiotics, and more broadly, antimicrobials, have been a cornerstone of modern medicine. But the overuse and misuse of these drugs have led to rising rates of antimicrobial resistance, which occurs when bacteria adapt in ways that render antibiotics ineffective. A world without effective antibiotics can have drastic impacts on population health, global development, and the global economy. As a global common good, antibiotic effectiveness is vulnerable to the tragedy of the commons, where a shared limited resource is overused by a community when each individual exploits the finite resource for their own benefit...
2018: Infectious Diseases
https://www.readbyqxmd.com/read/29684787/the-body-electric-2-0-recent-advances-in-developmental-bioelectricity-for-regenerative-and-synthetic-bioengineering
#11
REVIEW
Juanita Mathews, Michael Levin
Breakthroughs in biomedicine and synthetic bioengineering require predictive, rational control over anatomical structure and function. Recent successes in manipulating cellular and molecular hardware have not been matched by progress in understanding the patterning software implemented during embryogenesis and regeneration. A fundamental capability gap is driving desired changes in growth and form to address birth defects and traumatic injury. Here we review new tools, results, and conceptual advances in an exciting emerging field: endogenous non-neural bioelectric signaling, which enables cellular collectives to make global decisions and implement large-scale pattern homeostasis...
April 20, 2018: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29673918/-day-hospital-in-internal-medicine-a-chance-for-ambulatory-care
#12
A Grasland, E Mortier
INTRODUCTION: Internal medicine is an in-hospital speciality. Along with its expertise in rare diseases, it shares with general medicine the global care of patients but its place in the ambulatory shift has yet to be defined. The objective of our work was to evaluate the benefits of an internal medicine day-hospital devoted to general medicine. METHODS: Named "Centre Vi'TAL" to underline the link between the city and the hospital, this novel activity was implemented in order to respond quickly to general practitioners having difficulties to synthesize their complex patients or facing diagnostic or therapeutic problems...
April 16, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29666821/probiotics-for-the-control-of-helminth-zoonosis
#13
REVIEW
Abadi Amare Reda
This paper is a comprehensive, concise, and an up to date review about probiotics effect and mechanisms against helminth infections of zoonotic importance. Zoonoses are diseases that can be transmitted from animals to humans in a reversible way. Despite zoonotic helminth diseases being still a challenge to the public health and the agriculture industries globally, they were still neglected in both human and veterinary medicine. Moreover, the increasing emergence of anthelmintic drug resistance constitutes failures of most disease control strategies, alarming for a quest to new alternative control approaches...
2018: Journal of Veterinary Medicine
https://www.readbyqxmd.com/read/29650893/-towards-development-of-innovative-cancer-therapies-trans-omics-approach
#14
Reika Kawabata-Iwakawa, Masahiko Nishiyama
Comprehensive genomic and transcriptome analyses using next-generation sequencing(NGS)analysis has lead a discovery of a variety of novel driver gene mutations and new therapeutic targets for cancer patients, and has remarkably improved outcome of the patients through the development novel molecular targeting drugs. Even so, in so-called intractable or refractory cancers, those "druggable"alterations common to the diseases are rarely found due to the high diversity of the tumor. Furthermore, most of molecular target therapy is known to acquire the resistance to the drug by means of multiple factors such as up-regulation of the partially inhibited pathway, mutation of the target, activation of alternative pathways, histological translocation, and oncogene de-addiction...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29622286/the-german-emergency-and-disaster-medicine-and-management-system-history-and-present
#15
REVIEW
Norman Hecker, Bernd Dieter Domres
As well for optimized emergency management in individual cases as for optimized mass medicine in disaster management, the principle of the medical doctors approaching the patient directly and timely, even close to the site of the incident, is a long-standing marker for quality of care and patient survival in Germany. Professional rescue and emergency forces, including medical services, are the "Golden Standard" of emergency management systems. Regulative laws, proper organization of resources, equipment, training and adequate delivery of medical measures are key factors in systematic approaches to manage emergencies and disasters alike and thus save lives...
January 31, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29611474/glycosides-from-medicinal-plants-as-potential-anticancer-agents-emerging-trends-towards-future-drugs
#16
Haroon Khan, Mina Saeedi, Seyed Mohammad Nabavi, Mohammad S Mubarak, Anupam Bishayee
BACKGROUND: Cancer continues to be a global burden, despite the advancement of various technological and pharmaceutical improvements over the past two decades. Methods for treating cancer include surgery, radiotherapy and chemotherapy in addition to other specialized techniques. On the other hand, medicinal plants have been traditionally employed either as the complementary medicine or dietary agents in the treatment and management of cancer. Medicinal plants are a rich source of secondary metabolites with interesting biological and pharmacological activities...
April 3, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29609609/free-text-adversity-statements-as-part-of-a-contextualised-admissions-process-a-qualitative-analysis
#17
Lysa E Owen, Stephanie Ann Anderson, Johnathan S Dowell
BACKGROUND: Medical schools globally are encouraged to widen access and participation for students from less privileged backgrounds. Many strategies have been implemented to address this inequality, but much still needs to be done to ensure fair access for all. In the literature, adverse circumstances include financial issues, poor educational experience and lack of professional-status parents. In order to take account of adverse circumstances faced by applicants, The University of Dundee School of Medicine offers applicants the opportunity to report circumstances which may have resulted in disadvantage...
April 2, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29604079/genomic-epidemiology-of-multidrug-resistant-gram-negative-organisms
#18
REVIEW
Shawn E Hawken, Evan S Snitkin
The emergence and spread of antibiotic-resistant Gram-negative bacteria (rGNB) across global healthcare networks presents a significant threat to public health. As the number of effective antibiotics available to treat these resistant organisms dwindles, it is essential that we devise more effective strategies for controlling their proliferation. Recently, whole-genome sequencing has emerged as a disruptive technology that has transformed our understanding of the evolution and epidemiology of diverse rGNB species, and it has the potential to guide strategies for controlling the evolution and spread of resistance...
March 31, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29599720/ethnopharmacology-a-bibliometric-analysis-of-a-field-of-research-meandering-between-medicine-and-food-science
#19
Andy Wai Kan Yeung, Michael Heinrich, Atanas G Atanasov
Background: The research into bioactive natural products of medicinal plants has a long tradition, but ethnopharmacology as a well-defined field of research has a relatively short history, only dating back 50 years. Aims: With the fast development of this field and its global importance especially in the fast developing economies of Asia it is timely to assess the most influential articles (as measured by citations) and to identify important drivers and research trends in this field. Methods: Scopus was searched to identify relevant articles which were assessed by all three authors...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29596999/tithonia-diversifolia-hemsl-a-gray-as-a-medicinal-plant-a-comprehensive-review-of-its-ethnopharmacology-phytochemistry-pharmacotoxicology-and-clinical-relevance
#20
REVIEW
Alex Mabou Tagne, Franca Marino, Marco Cosentino
ETHNOPHARMACOLOGICAL RELEVANCE: Tithonia diversifolia (TD) is widely valued in several cultures for its medicinal properties. A comprehensive review of the current understanding of this plant species is required due to emerging concerns over its efficacy, toxicity and allergenic potential. AIM OF THE REVIEW: We critically summarized the current evidence on the botany, traditional use, phytochemistry, pharmacology and safety of TD, with the view to provide perspectives for developing more attractive pharmaceuticals of plant origin, but also to lay a new foundation for further investigations on this plant...
March 26, 2018: Journal of Ethnopharmacology
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