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JOURNAL ARTICLE
Junia C Santos-Silva, Rosane Aparecida Ribeiro, Jean F Vettorazzi, Esperanza Irles, Sarah Rickli, Patrícia C Borck, Patricia M Porciuncula, Ivan Quesada, Angel Nadal, Antonio C Boschero, Everardo M Carneiro
Taurine (Tau) regulates β-cell function and glucose homeostasis under normal and diabetic conditions. Here, we assessed the effects of Tau supplementation upon glucose homeostasis and the morphophysiology of endocrine pancreas, in leptin-deficient obese (ob) mice. From weaning until 90-day-old, C57Bl/6 and ob mice received, or not, 5% Tau in drinking water (C, CT, ob and obT). Obese mice were hyperglycemic, glucose intolerant, insulin resistant, and exhibited higher hepatic glucose output. Tau supplementation did not prevent obesity, but ameliorated glucose homeostasis in obT...
August 2015: Amino Acids
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