Linyan Shen, Yanyun Gu, Yixuan Qiu, Tingting Cheng, Aifang Nie, Canqi Cui, Chenyang Fu, Tingting Li, Xuelin Li, Lihong Fu, Yanqiu Wang, Qicheng Ni, Qidi Wang, Weiqing Wang, Bo Feng
Statins are cholesterol-lowering agents that increase the incidence of diabetes and impair glucose tolerance via their detrimental effects on nonhepatic tissues, such as pancreatic islets, but the underlying mechanism has not been determined. In atorvastatin (ator)-treated high-fat diet-fed mice, we found reduced pancreatic β-cell size and β-cell mass, fewer mature insulin granules and reduced insulin secretion and glucose tolerance. Transcriptome profiling of primary pancreatic islets showed that ator inhibited the expression of pancreatic transcription factor (TF), mTOR signaling and small G protein (sGP) genes...
October 24, 2019: Diabetes