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https://www.readbyqxmd.com/read/29128195/-what-support-of-young-presenting-a-first-psychotic-episode-when-schooling-is-being-challenged
#1
M-N Vacheron, H Veyrat-Masson, E Wehbe
Psychiatric disorders (more specifically mood disorders and psychosis) represent the 1st cause of disability among young people. Unemployment rate between 75 to 95% for the person with schizophrenia. It is correlated to poor social integration and bad economic status, worse symptomatology loss of autonomy as well as global bad functioning. It is responsible of more than half of the overall cost of psychosis. The onset of most of psychiatric disorders occur between the age of 25 and 35 years old, a critical time in young adult life when they should build their professional as well as social future...
November 8, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29121350/individualized-fsh-dosing-based-on-ovarian-reserve-testing-in-women-starting-ivf-icsi-a-multicentre-trial-and-cost-effectiveness-analysis
#2
Theodora C van Tilborg, Simone C Oudshoorn, Marinus J C Eijkemans, Monique H Mochtar, Ron J T van Golde, Annemieke Hoek, Walter K H Kuchenbecker, Kathrin Fleischer, Jan Peter de Bruin, Henk Groen, Madelon van Wely, Cornelis B Lambalk, Joop S E Laven, Ben Willem J Mol, Frank J M Broekmans, Helen L Torrance
STUDY QUESTION: Is there a difference in live birth rate and/or cost-effectiveness between antral follicle count (AFC)-based individualized FSH dosing or standard FSH dosing in women starting IVF or ICSI treatment? SUMMARY ANSWER: In women initiating IVF/ICSI, AFC-based individualized FSH dosing does not improve live birth rates or reduce costs as compared to a standard FSH dose. WHAT IS KNOWN ALREADY: In IVF or ICSI, ovarian reserve testing is often used to adjust the FSH dose in order to normalize ovarian response and optimize live birth rates...
November 7, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29121326/individualized-versus-standard-fsh-dosing-in-women-starting-ivf-icsi-an-rct-part-1-the-predicted-poor-responder
#3
Theodora C van Tilborg, Helen L Torrance, Simone C Oudshoorn, Marinus J C Eijkemans, Carolien A M Koks, Harold R Verhoeve, Annemiek W Nap, Gabrielle J Scheffer, A Petra Manger, Benedictus C Schoot, Alexander V Sluijmer, Arie Verhoeff, Henk Groen, Joop S E Laven, Ben Willem J Mol, Frank J M Broekmans
STUDY QUESTION: Does an increased FSH dose result in higher cumulative live birth rates in women with a predicted poor ovarian response, apparent from a low antral follicle count (AFC), scheduled for IVF or ICSI? SUMMARY ANSWER: In women with a predicted poor ovarian response (AFC < 11) undergoing IVF/ICSI, an increased FSH dose (225/450 IU/day) does not improve cumulative live birth rates as compared to a standard dose (150 IU/day). WHAT IS KNOWN ALREADY: In women scheduled for IVF/ICSI, an ovarian reserve test (ORT) can predict ovarian response to stimulation...
November 7, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29121269/individualized-versus-standard-fsh-dosing-in-women-starting-ivf-icsi-an-rct-part-2-the-predicted-hyper-responder
#4
Simone C Oudshoorn, Theodora C van Tilborg, Marinus J C Eijkemans, G Jur E Oosterhuis, Jaap Friederich, Marcel H A van Hooff, Evert J P van Santbrink, Egbert A Brinkhuis, Jesper M J Smeenk, Janet Kwee, Corry H de Koning, Henk Groen, Cornelis B Lambalk, Ben Willem J Mol, Frank J M Broekmans, Helen L Torrance
STUDY QUESTION: Does a reduced FSH dose in women with a predicted hyper response, apparent from a high antral follicle count (AFC), who are scheduled for IVF/ICSI lead to a different outcome with respect to cumulative live birth rate and safety? SUMMARY ANSWER: Although in women with a predicted hyper response (AFC > 15) undergoing IVF/ICSI a reduced FSH dose (100 IU per day) results in similar cumulative live birth rates and a lower occurrence of any grade of ovarian hyperstimulation syndrome (OHSS) as compared to a standard dose (150 IU/day), a higher first cycle cancellation rate and similar severe OHSS rate were observed...
November 7, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29117141/awareness-and-prevalence-of-mycotoxin-contamination-in-selected-nigerian-fermented-foods
#5
Ifeoluwa Adekoya, Patrick Njobeh, Adewale Obadina, Cynthia Chilaka, Sheila Okoth, Marthe De Boevre, Sarah De Saeger
Fermented food samples (n = 191) including maize gruel (ogi), sorghum gruel (ogi-baba), melon seed (ogiri), locust bean (iru) and African oil bean seed (ugba) from Southwest Nigeria were quantified for 23 mycotoxins, including aflatoxin B₁ (AFB₁), fumonisin B₁ (FB₁), and sterigmatocystin (STE) using liquid chromatography-tandem mass spectrometry. The practices, perceived understanding and health risks related to fungal and mycotoxin contamination amongst fermented food sellers was also established. Data obtained revealed that 82% of the samples had mycotoxins occurring singly or in combination...
November 8, 2017: Toxins
https://www.readbyqxmd.com/read/29112022/handover-structure-and-quality-in-the-acute-medical-assessment-unit-a-prospective-observational-study
#6
Ineke van der Wulp, Else P Poot, Prabath W B Nanayakkara, Stephan A Loer, Cordula Wagner
OBJECTIVES: Inadequate patient handovers are associated with the occurrence of medical errors. The objective of the present study was to explore the structure and quality of handovers in the acute medical assessment unit. METHODS: A prospective observational study was conducted in an academic hospital in the Netherlands. Handover structure was observed by ordering handover information according to the elements of the Situation, Background, Assessment, Recommendation, and Read back (SBAR-R) handover tool...
November 4, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/29106582/effectiveness-of-community-pharmacies-in-improving-seasonal-influenza-uptake-an-evaluation-using-the-donabedian-framework
#7
Gurpreet Kaur Rai, Annette Wood
Background: Community pharmacies are now commissioned nationally in England to provide a seasonal influenza vaccination service. However, there is little evidence about the effectiveness of a pharmacy-based immunization service in improving uptake. Methods: The Donabedian framework was used to evaluate a community pharmacy service in the West Midlands from a commissioning perspective. A mixed methods approach was adopted, including provider and patient surveys, data from the national influenza vaccination returns and an electronic pharmacy data recording system...
July 5, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/29106526/barriers-to-implement-screening-for-alcohol-consumption-in-spanish-hypertensive-patients
#8
Laia Miquel, Hugo López-Pelayo, Laura Nuño, José Ángel Arbesú, José Zarco, Jakob Manthey, Jürgen Rehm, Antoni Gual
Background: Alcohol intake and hypertension (HT) are interrelated public health problems with cost-effective interventions at the primary care level that, to date, are poorly implemented. Objective: This study aims to explore the barriers to implementing alcohol interventions for people with HT in primary care. Methods: As part of the project BASIS (Baseline Alcohol Screening and Intervention Survey), an internet survey from five European countries was developed to determine the role of alcohol in the management of HT in primary care practice...
November 2, 2017: Family Practice
https://www.readbyqxmd.com/read/29103138/a-new-prognostic-score-comprising-lactate-dehydrogenase-albumin-and-neutrophil-to-lymphocyte-ratio-to-predict-sensitivity-to-first-line-chemotherapy-in-patients-with-peripheral-t-cell-lymphomas
#9
Satoshi Kaito, Yusuke Kanemasa, Yuki Sasaki, Toshihiro Okuya, Tsukasa Yamaguchi, Chikako Funasaka, Tatsu Shimoyama, Yasushi Omuro, Tsunekazu Hishima, Yoshiharu Maeda
No standard therapy for peripheral T-cell lymphomas (PTCLs) has been established, and treatment outcomes are poor. Upfront stem cell transplantation has been investigated in several studies, some of which have reported promising outcomes. However, some patients maintain long-term remission after chemotherapy alone. It is thus important to predict sensitivity to first-line chemotherapy to optimize treatment strategies. In the present study, we retrospectively analyzed time to treatment failure (TTF) of first-line chemotherapy in 59 patients with PTCLs...
November 4, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29089949/comparative-proteomic-analysis-of-susceptible-and-resistant-rice-plants-during-early-infestation-by-small-brown-planthopper
#10
Yan Dong, Xianping Fang, Yong Yang, Gang-Ping Xue, Xian Chen, Weilin Zhang, Xuming Wang, Chulang Yu, Jie Zhou, Qiong Mei, Wang Fang, Chengqi Yan, Jianping Chen
The small brown planthopper (Laodelphax striatellus Fallén, Homoptera, Delphacidae-SBPH) is one of the major destructive pests of rice (Oryza sativa L.). Understanding on how rice responds to SBPH infestation will contribute to developing strategies for SBPH control. However, the response of rice plant to SBPH is poorly understood. In this study, two contrasting rice genotypes, Pf9279-4 (SBPH-resistant) and 02428 (SBPH-susceptible), were used for comparative analysis of protein profiles in the leaf sheath of rice plants in responses to SBPH infestation...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29083218/attending-to-relations-proportional-reasoning-in-3-to-6-year-old-children
#11
Michelle A Hurst, Sara Cordes
When proportional information is pit against whole number numerical information, children often attend to the whole number information at the expense of proportional information (e.g., indicating 4/9 is greater than 3/5 because 4 > 3). In the current study, we presented younger (3- to 4-year-olds) and older (5- to 6-year-olds) children a task in which the proportional information was presented either continuously (units cannot be counted) or discretely (countable units; numerical information available). In the discrete conditions, older children showed numerical interference-responding based on the number of pieces instead of the proportion of pieces...
October 30, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/29079613/enterococcus-faecalis-responds-to-individual-exogenous-fatty-acids-independently-of-saturation-or-chain-length
#12
Holly E Saito, John R Harp, Elizabeth M Fozo
Enterococcus faecalis is a commensal of the human gastrointestinal tract that can persist in the external environment and is a leading cause of hospital acquired infections. Given its diverse habitats, the organism has developed numerous strategies to survive a multitude of environmental conditions. Previous studies have demonstrated that E. faecalis will incorporate fatty acids from bile and serum into its membrane, resulting in an induced tolerance to membrane damaging agents. To discern whether all fatty acids induce membrane stress protection, we examined how E...
October 27, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29076004/high-mtor-expression-independently-prognosticates-poor-clinical-outcome-to-induction-chemotherapy-in-acute-lymphoblastic-leukemia
#13
Asheema Khanna, Bharat Bhushan, Pradeep Singh Chauhan, Sunita Saxena, Dipendra Kumar Gupta, Fouzia Siraj
In acute lymphoblastic leukemia (ALL), limited data are available on mTOR gene expression in clinical samples and its role in predicting response to induction chemotherapy. mRNA expression of mTOR gene was determined quantitatively by real-time PCR in 50 ALL patients (30 B-ALL and 20 T-ALL) and correlated with clinical outcome after induction chemotherapy. Expression level of mTOR was upregulated in more than 50% of cases of ALL. In T-ALL, high expression of mTOR was commonly seen, more in adults than children (82 vs...
October 26, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29072186/greek-teachers-knowledge-about-attention-deficit-hyperactivity-disorder
#14
I Giannopoulou, P Korkoliakou, E Pasalari, A Douzenis
Attention deficit hyperactivity disorder (ADHD) is a neurobiological disorder, which affects about 5.2% of school-aged children worldwide. Children with ADHD present teachers with a special challenge, since they interfere with teaching process and do not respond to typical classroom management techniques. In order to meet this challenge teachers must have accurate, up-to-date, information about the disorder so that they can respond to the needs of the student with ADHD. Studies that have examined teachers' beliefs and knowledge relating to ADHD highlighted the need for providing training to increase Greek teachers' knowledge and understanding of the disorder...
July 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29069451/poor-recovery-of-households-from-out-of-pocket-payment-for-assisted-reproductive-technology
#15
Silke J Dyer, Latiefa Vinoos, John E Ataguba
STUDY QUESTION: How do households recover financially from direct out-of-pocket payment for government subsidized ART? SUMMARY ANSWER: After a mean of 3.8 years, there was poor recovery from initiated financial coping strategies with the poorest households being disproportionatley affected. WHAT IS KNOWN ALREADY: Out-of-pocket payment for health services can create financial burdens for households and inequities in access to care. A previous study conducted at a public-academic institution in South Africa documented that patient co-payment for one cycle of ART resulted in catastrophic expenditure for one in five households, and more frequently among the poorest, requiring diverse financial coping strategies to offset costs...
October 21, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29066506/chemical-profiling-of-primary-mesothelioma-cultures-defines-subtypes-with-different-expression-profiles-and-clinical-responses
#16
Laurel Schunselaar, Josine M Quispel-Janssen, Yongsoo Kim, Constantine Alifrangis, Wilbert Zwart, Paul Baas, Jacques Neefjes
Finding new treatment options for patients with malignant pleural mesothelioma is challenging due to the rarity and heterogeneity of this cancer type. The absence of druggable targets further complicates the development of new therapies. Current treatment options are therefore limited and prognosis remains poor. EXPERIMENTAL DESIGN: We performed drug screening on primary mesothelioma cultures to guide treatment decisions of corresponding patients that were progressive after first or second line treatment...
October 24, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29063517/parp-inhibitors-in-the-treatment-of-triple-negative-breast-cancer
#17
REVIEW
Jill J J Geenen, Sabine C Linn, Jos H Beijnen, Jan H M Schellens
Breast cancer is a heterogeneous disease, manifesting in a broad differentiation in phenotypes and morphologic profiles, resulting in variable clinical behavior. Between 10 and 20% of all breast cancers are triple negative. Triple-negative breast cancer (TNBC) lacks the expression of human epidermal growth factor receptor 2 (HER2) and hormone receptors; therefore, to date, chemotherapy remains the backbone of treatment. TNBC tends to be aggressive and has a high histological grade, resulting in a poor 5-year prognosis...
October 23, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29058124/temporal-changes-in-bird-functional-diversity-across-the-united-states
#18
Jean-Yves Barnagaud, Pierre Gaüzère, Benjamin Zuckerberg, Karine Princé, Jens-Christian Svenning
Global changes are modifying the structure of species assemblages, but the generality of resulting diversity patterns and of their drivers is poorly understood. Any such changes can be detected and explained by comparing temporal trends in taxonomic and functional diversity over broad spatial extents. In this study, we addressed three complementary questions: How did bird taxonomic and functional diversity change over the past 40 years in the conterminous United States? Are these trends non-linear? Can temporal variations in functional diversity be explained by broad-scale changes in climate and vegetation productivity? We quantified changes in taxonomic and functional diversity for 807 bird assemblages over the past four decades (1970-2011) considering a suite of 16 ecological traits for 435 species...
December 2017: Oecologia
https://www.readbyqxmd.com/read/29045698/remission-in-psoriatic-arthritis-where-are-we-now
#19
Laura C Coates, Philip G Conaghan, Maria Antonietta D'Agostino, Maarten De Wit, Oliver FitzGerald, Tore K Kvien, Rik Lories, Philip Mease, Peter Nash, Georg Schett, Enrique R Soriano, Paul Emery
Advances in treatments and treatment strategies for PsA have led to many patients responding well to management of their disease, and targeting remission as a treatment goal is now a possibility. Treat to target is a strategy aimed at maximizing benefit, irrespective of the type of medication used, by monitoring disease activity and using it to guide therapy. The measurement of response to treatment has been the subject of wide discussions among experts for some time, and many instruments exist. Comparisons of the different measures and their different strengths and weaknesses is ongoing...
October 16, 2017: Rheumatology
https://www.readbyqxmd.com/read/29042027/too-much-of-a-good-thing-how-modulating-ltb4-actions-restore-host-defense-in-homeostasis-or-disease
#20
REVIEW
Stephanie L Brandt, C Henrique Serezani
The ability to regulate inflammatory pathways and host defense mechanisms is critical for maintaining homeostasis and responding to infections and tissue injury. While unbalanced inflammation is detrimental to the host; inadequate inflammation might not provide effective signals required to eliminate pathogens. On the other hand, aberrant inflammation could result in organ damage and impair host defense. The lipid mediator leukotriene B4 (LTB4) is a potent neutrophil chemoattractant and recently, its role as a dominant molecule that amplifies many arms of phagocyte antimicrobial effector function has been unveiled...
October 2017: Seminars in Immunology
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