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https://www.readbyqxmd.com/read/28635413/the-high-responder-a-review-of-pathophysiology-and-outcomes-during-ivf-treatment
#1
Mariano Mascarenhas, Adam H Balen
This review attempts to summarize the known literature on high responders to ovarian stimulation during assisted reproductive techniques (ART). Response to gonadotrophins is subject to significant interindividual and intercycle variation, thus carrying a risk of high response or poor response to ovarian stimulation regimens. The main risk for high responders is the development of ovarian hyperstimulation syndrome (OHSS) which is associated with significant morbidity. Hence, the definition of high responders in the literature has primarily focussed on risk factors for OHSS...
February 28, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28632192/coverage-and-influencing-determinants-of-influenza-vaccination-in-elderly-patients-in-a-country-with-a-poor-vaccination-implementation
#2
Maria Ganczak, Karolina Gil, Marcin Korzeń, Marta Bażydło
The seasonal influenza vaccination uptake of the elderly in Poland is one of the lowest in Europe. Objective: to assess the vaccination coverage and influencing determinants in patients ≥65 years of age. METHODS: A cross-sectional study was conducted (November 2015-April 2016) among consecutive patients admitted to a municipal hospital located in the city of Szczecin, North-west Poland. Patients completed researcher-administered, anonymous questionnaires on socio- demographic data/factors related to the vaccination...
June 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28617616/the-role-of-nrf2-in-the-regulation-of-periodontal-health-and-disease
#3
A V Chiu, M Al Saigh, C A McCulloch, M Glogauer
Immune-related disease tolerance is an important defense strategy that facilitates the maintenance of health in organs and tissues that are commonly colonized by bacteria. Immune tolerance to dysbiotic, tooth-borne biofilms is a poorly understood yet clinically relevant concept in the immunopathological mechanisms that are involved in the pathogenesis of periodontitis, particularly those related to neutrophil and macrophage responses. In periodontal health, neutrophils and macrophages respond to the formation of pathogenic bacterial biofilms by the production of bactericidal reactive oxygen species (ROS)...
June 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28617432/bst2-confers-cisplatin-resistance-via-nf-%C3%AE%C2%BAb-signaling-in-nasopharyngeal-cancer
#4
Chun-Mei Kuang, Xiang Fu, Yi-Jun Hua, Wen-di Shuai, Zhi-Hua Ye, Yingchang Li, Qi-Hua Peng, Yi-Zhuo Li, Shuai Chen, Chao-Nan Qian, Wenlin Huang, Ran-Yi Liu
Concurrent/adjuvant cisplatin-based chemoradiotherapy is regarded as the standard of treatment for locoregionally advanced nasopharyngeal carcinoma (NPC). However, patients who do not respond to cisplatin suffer, rather than benefit, from chemotherapy treatment. The goal of this study was to identify molecules involved in cisplatin resistance and to clarify their molecular mechanisms, which would help in the discovery of potential therapeutic targets and in developing a personalized and precise treatment approach for NPC patients...
June 15, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28610654/periprosthetic-infection-in-joint-replacement
#5
Christina Otto-Lambertz, Ayla Yagdiran, Franziska Wallscheid, Peer Eysel, Norma Jung
BACKGROUND: The volume of joint replacement surgery has risen steadily in recent years, because the population is aging and increasingly wishes to reserve a high functional status onward into old age. Infection is among the more common complications of joint replacement surgery, arising in 0.2% to 2% of patients, or as many as 9% in special situations such as the implantation of megaprostheses. The associated morbidity and mortality are high. It is thus very important to minimize risk factors for infection and to optimize the relevant diagnostic and therapeutic strategies...
May 26, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28606174/using-multiclass-classification-to-automate-the-identification-of-patient-safety-incident-reports-by-type-and-severity
#6
Ying Wang, Enrico Coiera, William Runciman, Farah Magrabi
BACKGROUND: Approximately 10% of admissions to acute-care hospitals are associated with an adverse event. Analysis of incident reports helps to understand how and why incidents occur and can inform policy and practice for safer care. Unfortunately our capacity to monitor and respond to incident reports in a timely manner is limited by the sheer volumes of data collected. In this study, we aim to evaluate the feasibility of using multiclass classification to automate the identification of patient safety incidents in hospitals...
June 12, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28594714/tailored-treatment-strategy-for-locally-advanced-rectal-carcinoma-based-on-the-tumor-response-to-induction-chemotherapy-preliminary-results-of-the-french-phase-ii-multicenter-greccar4-trial
#7
Philippe Rouanet, Eric Rullier, Bernard Lelong, Philippe Maingon, Jean-Jacques Tuech, Denis Pezet, Florence Castan, Stéphanie Nougaret
BACKGROUND: Preoperative radiochemotherapy and total mesorectal excision are the standard-of-care for locally advanced rectal carcinoma, but some patients could be over- or undertreated. OBJECTIVE: This study aimed to assess the feasibility of radiochemotherapy tailored based on the tumor response to induction chemotherapy (FOLFIRINOX) to obtain a minimum R0 resection rate of 90% in the 4 arms of the study. DESIGN: This study is a multicenter randomized trial (NCT01333709)...
July 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28587484/seven-year-follow-up-of-matrix-induced-autologous-implantation-in-talus-articular-defects
#8
Christopher Kreulen, Eric Giza, Judie Walton, Martin Sullivan
BACKGROUND: Osteochondral lesions of the talus (OLT) are difficult to treat because of the poor intrinsic healing capability of articular cartilage. Matrix-induced autologous chondrocyte implantation (MACI) has been shown to be a reliable method for treating cartilage lesions that fail to respond to traditional microfracture and debridement. The purpose of this study was to assess 7-year clinical follow-up data of this technique and demonstrate midterm success of this implant. METHODS: A prospective investigation of MACI was performed on 10 patients with OLTs who had failed previous arthroscopic treatment...
June 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28586388/a-prospective-pilot-study-of-genome-wide-exome-and-transcriptome-profiling-in-patients-with-small-cell-lung-cancer-progressing-after-first-line-therapy
#9
Glen J Weiss, Sara A Byron, Jessica Aldrich, Ashish Sangal, Heather Barilla, Jeffrey A Kiefer, John D Carpten, David W Craig, Timothy G Whitsett
BACKGROUND: Small cell lung cancer (SCLC) that has progressed after first-line therapy is an aggressive disease with few effective therapeutic strategies. In this prospective study, we employed next-generation sequencing (NGS) to identify therapeutically actionable alterations to guide treatment for advanced SCLC patients. METHODS: Twelve patients with SCLC were enrolled after failing platinum-based chemotherapy. Following informed consent, genome-wide exome and RNA-sequencing was performed in a CLIA-certified, CAP-accredited environment...
2017: PloS One
https://www.readbyqxmd.com/read/28582947/age-related-associations-between-work-over-commitment-and-zest-for-work-among-swedish-employees-from-a-cross-sectional-and-longitudinal-perspective
#10
Roma Runeson-Broberg, Jean-Baptist du Prel, Peter Westerholm, Maria Nordin, Anders Knutsson, Lars Alfredsson, Göran Fahlén, Richard Peter
BACKGROUND: In aging societies, zest for work may be pivotal when deciding to stay occupationally active longer. Psychosocial work stress is a prevalent public health problem and may have an impact on zest for work. Work over-commitment (WOC) is a personal coping strategy for work stress with excessive striving and a health risk. However, the long-term effect of WOC on zest for work is poorly understood. OBJECTIVE: To investigate the age-related associations of work over-commitment with zest for work...
June 1, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28577810/findings-from-the-inane-survey-on-student-papers-submitted-to-nursing-journals
#11
Maureen Shawn Kennedy, Jamesetta A Newland, Jacqueline K Owens
Nursing students are often encouraged or required to submit scholarly work for consideration for publication but most manuscripts or course assignment papers do not meet journal standards and consume valuable resources from editors and peer reviewers. The International Academy of Nursing Editors (INANE) is a group of nurse editors and publishers dedicated to promoting best practices in publishing in the nursing literature. In August 2014, editors at INANE's annual meeting voiced frustrations over multiple queries, poorly written student papers, and lack of proper behavior in following through...
May 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/28576890/perceived-challenges-to-achieving-universal-health-coverage-a-cross-sectional-survey-of-social-health-insurance-managers-administrators-in-china
#12
Linghan Shan, Qunhong Wu, Chaojie Liu, Ye Li, Yu Cui, Zi Liang, Yanhua Hao, Libo Liang, Ning Ning, Ding Ding, Qingxia Pan, Liyuan Han
OBJECTIVE: China has achieved over 96% health insurance coverage. However, universal health coverage (UHC) entails population coverage and the range of services covered and the extent to which health service costs are covered. This study aimed to determine the performance of the health insurance system in China in terms of its role in UHC and to identify challenges in the progress of UHC as perceived by health insurance managers/administrators. METHODS: A cross-sectional questionnaire survey was conducted in Beijing, Ningbo, Harbin and Chongqing over the period of 2014 and 2015...
June 2, 2017: BMJ Open
https://www.readbyqxmd.com/read/28544416/global-analysis-of-strategies-to-tackle-antimicrobial-resistance
#13
Funke Adeniji
BACKGROUND: Antimicrobial resistance (AMR) is a global public health issue driven by inappropriate use of antimicrobials resulting in decreased efficacy on the background of an extremely limited pipeline for new antibiotics. We sought to analyse the effectiveness of key policies and strategies in tackling AMR globally and identify gaps in these. METHOD: The scope, magnitude, history and drivers of AMR were reviewed using supporting evidence. Our methodology included a literature review and semi-structured survey, whilst the analyses process was guided by an adapted health policy analyses framework...
May 22, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28542304/the-new-normal-adapting-doctoral-trainee-career-preparation-for-broad-career-paths-in-science
#14
Rebekah St Clair, Tamara Hutto, Cora MacBeth, Wendy Newstetter, Nael A McCarty, Julia Melkers
Doctoral recipients in the biomedical sciences and STEM fields are showing increased interest in career opportunities beyond academic positions. While recent research has addressed the interests and preferences of doctoral trainees for non-academic careers, the strategies and resources that trainees use to prepare for a broad job market (non-academic) are poorly understood. The recent adaptation of the Social Cognitive Career Theory to explicitly highlight the interplay of contextual support mechanisms, individual career search efficacy, and self-adaptation of job search processes underscores the value of attention to this explicit career phase...
2017: PloS One
https://www.readbyqxmd.com/read/28542225/the-impact-of-health-promotion-on-trachoma-knowledge-attitudes-and-practice-kap-of-staff-in-three-work-settings-in-remote-indigenous-communities-in-the-northern-territory
#15
Fiona D Lange, Kelly Jones, Rebecca Ritte, Haley E Brown, Hugh R Taylor
BACKGROUND: Globally, trachoma is the leading cause of infectious blindness and Australia is the only developed country with endemic trachoma. It is found in remote Indigenous communities burdened with poverty, overcrowding and poor hygiene. Lack of culturally appropriate health promotion, a small trachoma workforce and lack of awareness and support for trachoma elimination in general, were early barriers. METHODS: A cross-sectional pre-post study using a convenience sample, was conducted in clinics, schools and community work-settings from 63 of the 82 remote Aboriginal communities identified as being at risk of trachoma in the Northern Territory (NT)...
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28533696/experience-of-dysmenorrhea-among-a-group-of-physical-therapy-students-from-cairo-university-an-exploratory-study
#16
Dalia M Kamel, Sayed A Tantawy, Gehan A Abdelsamea
INTRODUCTION: Dysmenorrhea is a condition describing the painful cramps that women feel before or during the menstrual period. While dysmenorrhea is the most common gynecologic complaint affecting adolescent and young women and there has been significant progress in understanding its pathophysiology and managing the symptoms, many young women do not seek medical consultation and remain untreated. AIM OF THE STUDY: The aim of the study was to explore the prevalence of dysmenorrhea, its physical impact, and associated coping behaviors among university students...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28522791/career-in-vascular-surgery-the-medical-student-s-perspective
#17
Malwina K Grobelna, Hubert Stępak, Barbara Kołodziejczak, Łukasz Dzieciuchowicz, Grzegorz Oszkinis
AIM: Under the supervision of the Department of General and Vascular Surgery of Poznan University of Medical Sciences, a questionnaire was distributed online or as a paper version to medical students (MSs) in order to better understand the attitudes towards surgery as a specialty and to determine the reasons why students do and do not choose vascular surgery as their career path. MATERIALS AND METHODS: The questionnaire was distributed online or as a paper version to MSs in the 3rd, 5th, and 6th year of the PUMS 6-year M...
February 28, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28499007/shifts-in-microbial-trophic-strategy-explain-different-temperature-sensitivity-of-co2-flux-under-constant-and-diurnally-varying-temperature-regimes
#18
Zhen Bai, Hongtu Xie, Jenny Kao-Kniffin, Baodong Chen, Pengshuai Shao, Chao Liang
Understanding soil CO2 flux temperature sensitivity (Q10) is critical for predicting ecosystem-level responses to climate change. Yet, the effects of warming on microbial CO2 respiration still remain poorly understood under current Earth system models, partly as a result of thermal acclimation of organic matter decomposition. We conducted a 117-day incubation experiment under constant and diurnally varying temperature treatments based on four forest soils varying in vegetation stand and soil horizon. Our results showed that Q10 was greater under varying than constant temperature regimes...
May 1, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28491236/self-referral-patterns-among-federal-civil-servants-in-oyo-state-south-western-nigeria
#19
Henry Okoli, Taiwo Obembe, Kayode Osungbade, Folashayo Adeniji, David Adewole
INTRODUCTION: Primary health care is widely accepted as the first point of care; yet, individuals requiring healthcare engage in self-referrals to higher levels of care thereby by-passing primary care. Little is known of the extent to which self-referrals are carried out when care is needed. This study thus sought to determine the prevalence of self-referral, its patterns and factors influencing self-referrals amongst federal civil servants in Southwestern Nigeria. METHODS: A cross-sectional study was carried out among 300 federal civil servants who were interviewed using validated and pre-tested interviewer-administered semi structured questionnaires...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28485693/rapid-assessment-of-facilitators-and-barriers-related-to-the-acceptance-challenges-and-community-perception-of-daily-regimen-for-treating-tuberculosis-in-india
#20
Himanshu Negandhi, Ritika Tiwari, Anjali Sharma, Rajesh Nair, Sanjay Zodpey, Ramesh Reddy Allam, Ganesh Oruganti
INTRODUCTION: The Revised National Tuberculosis Control Program (RNTCP) is the largest tuberculosis (TB) control program in the world based on Directly Observed Treatment Short-Course (DOTS) strategy. Globally, most countries have been using a daily regimen and in India a shift towards a daily regimen for TB treatment has already begun. The daily strategy is known to improve program coverage along with compliance. Such strategic shifts have both management and operational implications...
2017: Global Health Action
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