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https://www.readbyqxmd.com/read/28087485/stepwise-targeted-drug-delivery-to-liver-cancer-cells-for-enhanced-therapeutic-efficacy-by-galactose-grafted-ultra-ph-sensitive-micelles
#1
Guoqing Yan, Jun Wang, Liefeng Hu, Xin Wang, Guanqing Yang, Shengxiang Fu, Xu Cheng, Panpan Zhang, Rupei Tang
: To promote drug accumulation and cell-killing ability at tumor tissue, we have prepared a stepwise targeted drug delivery system that can remain stealthy and long-circulating in the blood vessels, improve drug retention at extracellular stimuli, enhance cellular uptake through special targeting ligands, and then achieve rapid drug release to improve toxicity to tumor cells at intracellular stimuli. Herein, galactose-grafted, ultra-pH-sensitive drug carriers (POEAd-g-LA-DOX micelles), which could respond to both extracellular and intracellular pH, and combine with galactose-receptors in cell membrane, were constructed by a facile method, therefore achieving: (i) remaining stable at pH 7...
January 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28087467/positive-childhood-experiences-and-ideal-cardiovascular-health-in-midlife-associations-and-mediators
#2
Natalie Slopen, Ying Chen, Jennifer L Guida, Michelle A Albert, David R Williams
In 2010, the American Heart Association introduced a new conceptual framework to encourage a focus on primary prevention and provided a definition for "ideal cardiovascular health". In this study we examined the relationship between positive childhood experience and ideal cardiovascular health in mid-life, and the extent to which education, depression, and social support mediate this association. Data are from participants in the Midlife and Aging in the United States study who completed a clinic-based assessment of health (N=1255, aged 34-84years, 2004-2005)...
January 10, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28081174/definition-of-human-epitopes-recognized-in-tetanus-toxoid-and-development-of-an-assay-strategy-to-detect-ex-vivo-tetanus-cd4-t-cell-responses
#3
Ricardo da Silva Antunes, Sinu Paul, John Sidney, Daniela Weiskopf, Jennifer M Dan, Elizabeth Phillips, Simon Mallal, Shane Crotty, Alessandro Sette, Cecilia S Lindestam Arlehamn
Despite widespread uses of tetanus toxoid (TT) as a vaccine, model antigen and protein carrier, TT epitopes have been poorly characterized. Herein we defined the human CD4+ T cell epitope repertoire by reevaluation of previously described epitopes and evaluation of those derived from prediction of HLA Class II binding. Forty-seven epitopes were identified following in vitro TT stimulation, with 28 epitopes accounting for 90% of the total response. Despite this diverse range of epitopes, individual responses were associated with only a few immunodominant epitopes, with each donor responding on average to 3 epitopes...
2017: PloS One
https://www.readbyqxmd.com/read/28074746/oncology-s-trojan-horse-using-viruses-to-battle-cancer
#4
Heena J Mavani, Jeannette Y Wick
: In 2016, the American health care system was faced with more than 1.6 million new cases of cancer, and individuals older than 65 years of age will be affected disproportionately. Many older individuals are poor candidates for traditional treatments (e.g., chemotherapy, radiation) because of actual or potential treatment-related adverse events. Researchers continuously look for novel therapeutic strategies, and an exciting new one is on the horizon: virotherapy. Viruses' ability to infect and kill human cells makes them promising cancer treatments...
December 1, 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28072938/welfare-of-anaesthesia-trainees-survey
#5
G B Downey, J M McDonald, R G Downey
This study was designed to investigate levels of stress, anxiety or depression and to identify factors compounding or relieving stress in anaesthesia trainees within the Australian and New Zealand College of Anaesthetists (ANZCA) training scheme. An electronic survey was sent to 999 randomly selected trainees and 428 responses were received. In addition to demographics, psychological wellbeing was assessed using the Kessler Psychological Distress Scale (K10) and questions were asked about depression and anxiety, exacerbating factors, personal healthcare and strategies used to manage stress...
January 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28058727/exppning-how-acetylcholine-improves-gait-in-parkinson-s-disease-an-editorial-highlight-for-deletion-of-the-vesicular-acetylcholine-transporter-from-pedunculopontine-laterodorsal-tegmental-neurons-modifies-gait
#6
EDITORIAL
Björn Falkenburger
Gait impairment is one of the most intractable symptoms of Parkinson's disease, responding poorly to dopaminergic medication. Promising therapeutic strategies include deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) and enhancing cholinergic neurotransmission by acetylcholine esterase inhibitors. This Editorial discusses an elegant study by Janickova and coworkers in the current issue of the Journal of Neurochemistry, in which the authors engineered mice lacking cholinergic transmission selectively in the PPN and demonstrate that cholinergic neurons of the PPN are critical for gait...
January 6, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28051830/gambling-and-the-need-for-new-responses-in-public-health-with-an-addiction-sine-substantia
#7
M Crusco, F Massoni, E Luzi, P Ricci, M Pelosi, P Corbosiero, M Rapp-Ricciardi, S Ricci
BACKGROUND: The Gambling Disorder (GD) was recently defined as a behavioral addiction by the "The Diagnostic and Statistical Manual of Mental Disorders IV"( DSM-V) since the clinical, neurobiological and psychopathological similarities led it to be defined it as an addiction "sine substantia". The aim of this study is to formulate an "identikit" of the gambler, to evaluate a possible association between GD / emotional specific factors and the correlation between GD / substance abuse, GD / suicide...
November 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28048504/th-c-204-00-medical-physics-workshop-an-update-on-the-journal-s-improvement-activities-and-guidance-on-writing-and-reviewing-papers
#8
Jeffrey Williamson
In this presentation, the Editors will outline our vision for the future of Medical Physics and review recent work-in-progress initiatives to implement this vision. Finally, we will close with guidance to authors on how to write a good Medical Physics paper. A major focus will be the transition to a new publisher in 2017 following a more than 40-year association with American Institute of Physics Publishing (AIPP). Vision for Medical Physics and status of current initiatives: Jeff Williamson, Editor-in-Chief The broad vision of Medical Physics is "to continue the Journal's tradition of publishing the very best science that propels our discipline forward and improves our contribution to patient care...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048316/th-c-204-03-writing-good-scientific-papers-and-responding-to-critiques
#9
M Goodsitt
In this presentation, the Editors will outline our vision for the future of Medical Physics and review recent work-in-progress initiatives to implement this vision. Finally, we will close with guidance to authors on how to write a good Medical Physics paper. A major focus will be the transition to a new publisher in 2017 following a more than 40-year association with American Institute of Physics Publishing (AIPP). Vision for Medical Physics and status of current initiatives: Jeff Williamson, Editor-in-Chief The broad vision of Medical Physics is "to continue the Journal's tradition of publishing the very best science that propels our discipline forward and improves our contribution to patient care...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046896/th-c-204-01-vision-for-medical-physics-and-status-of-current-initiatives
#10
J Williamson
In this presentation, the Editors will outline our vision for the future of Medical Physics and review recent work-in-progress initiatives to implement this vision. Finally, we will close with guidance to authors on how to write a good Medical Physics paper. A major focus will be the transition to a new publisher in 2017 following a more than 40-year association with American Institute of Physics Publishing (AIPP). Vision for Medical Physics and status of current initiatives: Jeff Williamson, Editor-in-Chief The broad vision of Medical Physics is "to continue the Journal's tradition of publishing the very best science that propels our discipline forward and improves our contribution to patient care...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046238/th-c-204-02-improving-manuscript-quality-via-structured-reviews-enhanced-scientific-category-taxonomy-and-outreach
#11
S Das
In this presentation, the Editors will outline our vision for the future of Medical Physics and review recent work-in-progress initiatives to implement this vision. Finally, we will close with guidance to authors on how to write a good Medical Physics paper. A major focus will be the transition to a new publisher in 2017 following a more than 40-year association with American Institute of Physics Publishing (AIPP). Vision for Medical Physics and status of current initiatives: Jeff Williamson, Editor-in-Chief The broad vision of Medical Physics is "to continue the Journal's tradition of publishing the very best science that propels our discipline forward and improves our contribution to patient care...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28027948/safe-approaches-for-camptothecin-delivery-structural-analogues-and-nanomedicines
#12
REVIEW
Pablo Botella, Eva Rivero-Buceta
Twenty-(S)-camptothecin is a strongly cytotoxic molecule with excellent antitumor activity over a wide spectrum of human cancers. However, the direct formulation is limited by its poor water solubility, low plasmatic stability and severe toxicity, which currently limits its clinical use. As a consequence, two strategies have been developed in order to achieve safe and efficient delivery of camptothecin to target cells: structural analogues and nanomedicines. In this review, we summarize recent advances in the design, synthesis and development of camptothecin molecular derivatives and supramolecular vehicles, following a systematic classification according to structure-activity relationships (structural analogues) or chemical nature (nanomedicines)...
December 24, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28006005/rapid-assessment-of-ecosystem-service-co-benefits-of-biodiversity-priority-areas-in-madagascar
#13
Rachel A Neugarten, Miroslav Honzák, Pierre Carret, Kellee Koenig, Luciano Andriamaro, Carlos Andres Cano, Hedley S Grantham, David Hole, Daniel Juhn, Madeleine McKinnon, Andriambolantsoa Rasolohery, Marc Steininger, Timothy Max Wright, Will R Turner
The importance of ecosystems for supporting human well-being is increasingly recognized by both the conservation and development sectors. Our ability to conserve ecosystems that people rely on is often limited by a lack of spatially explicit data on the location and distribution of ecosystem services (ES), the benefits provided by nature to people. Thus there is a need to map ES to guide conservation investments, to ensure these co-benefits are maintained. To target conservation investments most effectively, ES assessments must be rigorous enough to support conservation planning, rapid enough to respond to decision-making timelines, and often must rely on existing data...
2016: PloS One
https://www.readbyqxmd.com/read/27988853/status-of-bovine-tuberculosis-and-its-zoonotic-implications-in-borana-zone-southern-ethiopia
#14
Ararsa Duguma, Shubisa Abera, Wubishet Zewdie, Dinaol Belina, Godana Haro
A cross-sectional study was carried out from April 2015 to June 2016 to estimate the status of bovine tuberculosis (BTB), assessment of community's current knowledge, and zoonotic importance on this disease in Borana zone, southern Ethiopia. In this study, comparative intradermal tuberculin (CIDT) test, structured questionnaires, and retrospective data were used, while the result indicated 3.8% prevalence at individual animal level with 5.6% (31/554) of doubtful reactors. Among related risk factors included, old animals were significantly infected by BTB than young one (χ (2) = 32...
December 17, 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27959918/the-presence-persistence-and-functional-properties-of-plasmodium-vivax-duffy-binding-protein-ii-antibodies-are-influenced-by-hla-class-ii-allelic-variants
#15
Flora S Kano, Flávia A Souza-Silva, Leticia M Torres, Barbara A S Lima, Taís N Sousa, Jéssica R S Alves, Roberto S Rocha, Cor J F Fontes, Bruno A M Sanchez, John H Adams, Cristiana F A Brito, Douglas E V Pires, David B Ascher, Ana Maria Sell, Luzia H Carvalho
BACKGROUND: The human malaria parasite Plasmodium vivax infects red blood cells through a key pathway that requires interaction between Duffy binding protein II (DBPII) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). A high proportion of P. vivax-exposed individuals fail to develop antibodies that inhibit DBPII-DARC interaction, and genetic factors that modulate this humoral immune response are poorly characterized. Here, we investigate if DBPII responsiveness could be HLA class II-linked...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27935483/predicting-sport-and-occupational-lower-extremity-injury-risk-through-movement-quality-screening-a-systematic-review
#16
Jackie L Whittaker, Nadine Booysen, Sarah de la Motte, Liz Dennett, Cara L Lewis, Dave Wilson, Carly McKay, Martin Warner, Darin Padua, Carolyn A Emery, Maria Stokes
BACKGROUND: Identification of risk factors for lower extremity (LE) injury in sport and military/first-responder occupations is required to inform injury prevention strategies. OBJECTIVE: To determine if poor movement quality is associated with LE injury in sport and military/first-responder occupations. MATERIALS AND METHODS: 5 electronic databases were systematically searched. Studies selected included original data; analytic design; movement quality outcome (qualitative rating of functional compensation, asymmetry, impairment or efficiency of movement control); LE injury sustained with sport or military/first-responder occupation...
December 1, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27930661/chronic-diseases-health-behaviors-and-demographic-characteristics-as-predictors-of-ill-health-retirement-findings-from-the-korea-health-panel-survey-2008-2012
#17
Young Joong Kang, Mo-Yeol Kang
PURPOSE: The research aim was to identify demographic characteristics, chronic diseases, and unhealthy behaviors predicting ill health retirement in South Korea. METHODS: Data were collected from 15,407 individuals enrolled in the first through the fifth phases of the Korea Health Panel Survey (2008-2012) using structured questionnaires examining retirement, morbidities, and health-related behaviors. The Cox proportional hazard model was used to examine demographic and clinical characteristics' effects on ill health retirement...
2016: PloS One
https://www.readbyqxmd.com/read/27926740/a-17-gene-stemness-score-for-rapid-determination-of-risk-in-acute-leukaemia
#18
Stanley W K Ng, Amanda Mitchell, James A Kennedy, Weihsu C Chen, Jessica McLeod, Narmin Ibrahimova, Andrea Arruda, Andreea Popescu, Vikas Gupta, Aaron D Schimmer, Andre C Schuh, Karen W Yee, Lars Bullinger, Tobias Herold, Dennis Görlich, Thomas Büchner, Wolfgang Hiddemann, Wolfgang E Berdel, Bernhard Wörmann, Meyling Cheok, Claude Preudhomme, Herve Dombret, Klaus Metzeler, Christian Buske, Bob Löwenberg, Peter J M Valk, Peter W Zandstra, Mark D Minden, John E Dick, Jean C Y Wang
Refractoriness to induction chemotherapy and relapse after achievement of remission are the main obstacles to cure in acute myeloid leukaemia (AML). After standard induction chemotherapy, patients are assigned to different post-remission strategies on the basis of cytogenetic and molecular abnormalities that broadly define adverse, intermediate and favourable risk categories. However, some patients do not respond to induction therapy and another subset will eventually relapse despite the lack of adverse risk factors...
December 15, 2016: Nature
https://www.readbyqxmd.com/read/27920321/many-mobile-health-apps-target-high-need-high-cost-populations-but-gaps-remain
#19
Karandeep Singh, Kaitlin Drouin, Lisa P Newmark, JaeHo Lee, Arild Faxvaag, Ronen Rozenblum, Erika A Pabo, Adam Landman, Elissa Klinger, David W Bates
With rising smartphone ownership, mobile health applications (mHealth apps) have the potential to support high-need, high-cost populations in managing their health. While the number of available mHealth apps has grown substantially, no clear strategy has emerged on how providers should evaluate and recommend such apps to patients. Key stakeholders, including medical professional societies, insurers, and policy makers, have largely avoided formally recommending apps, which forces patients to obtain recommendations from other sources...
December 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27911401/an-optimized-protocol-to-analyze-glycolysis-and-mitochondrial-respiration-in-lymphocytes
#20
Javier Traba, Pietro Miozzo, Billur Akkaya, Susan K Pierce, Munir Akkaya
Lymphocytes respond to a variety of stimuli by activating intracellular signaling pathways, which in turn leads to rapid cellular proliferation, migration and differentiation, and cytokine production. All of these events are tightly linked to the energy status of the cell, and therefore studying the energy-producing pathways may give clues about the overall functionality of these cells. The extracellular flux analyzer is a commonly used device for evaluating the performance of glycolysis and mitochondrial respiration in many cell types...
November 21, 2016: Journal of Visualized Experiments: JoVE
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