keyword
MENU ▼
Read by QxMD icon Read
search

strategy on poor responder

keyword
https://www.readbyqxmd.com/read/28296887/migrant-women-s-experiences-meanings-and-ways-of-dealing-with-postnatal-depression-a-meta-ethnographic-study
#1
Virginia Schmied, Emma Black, Norell Naidoo, Hannah G Dahlen, Pranee Liamputtong
AIM: To conduct a meta-ethnographic study of the experiences, meanings and ways of 'dealing with' symptoms or a diagnosis of postnatal depression amongst migrant women living in high income countries. BACKGROUND: Prevalence of postnatal depression is highest amongst women who are migrants. Yet many women do not seek help for their symptoms and health services do not always respond appropriately to migrant women's needs. Studies have reported migrant women's experiences of postnatal depression and it is timely to synthesise findings from these studies to understand how services can be improved...
2017: PloS One
https://www.readbyqxmd.com/read/28289109/minding-the-gap-factors-associated-with-primary-care-coordination-of-adults-in-11-countries
#2
Jonathan Penm, Neil J MacKinnon, Stephen M Strakowski, Jun Ying, Michelle M Doty
PURPOSE: Care coordination has been identified as a key strategy in improving the effectiveness, safety, and efficiency of the US health care system. Our objective was to determine whether population or health care system issues are associated with primary care coordination gaps in the United States and other high-income countries. METHODS: We analyzed data from the 2013 Commonwealth Fund International Health Policy (IHP) survey with multivariate logistic regression analysis...
March 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28284966/the-impact-of-primary-treatment-strategy-on-vestibular-schwannoma-patient-quality-of-life
#3
Robert W Foley, Robert M Maweni, Hussein Jaafar, Rory McConn Walsh, Mohsen Javadpour, Daniel Rawluk
OBJECTIVE: To assess the quality of life (QoL) in a representative sample of vestibular schwannoma patients and to ascertain the differences in outcomes associated with distinct management strategies. PATIENTS & METHODS: Vestibular Schwannoma patients attending a tertiary referral centre were asked to complete the FACT-Br Questionnaire, which assesses QoL in five domains: physical, social, emotional and functional and a brain cancer specific domain. Results were analysed in the overall cohort and in surgery, stereotactic radiosurgery and conservative management subgroups...
March 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28268259/intravesical-bacillus-calmette-gu%C3%A3-rin-with-interferon-alpha-versus-intravesical-bacillus-calmette-gu%C3%A3-rin-for-treating-non-muscle-invasive-bladder-cancer
#4
REVIEW
Andrew Rh Shepherd, Emily Shepherd, Nicholas R Brook
BACKGROUND: Despite local therapies, commonly transurethral resection (TUR) followed by adjuvant treatments, non-muscle-invasive bladder cancer (NMIBC) has a high rate of recurrence and progression. Intravesical Bacillus Calmette-Guérin (BCG) has been shown to reduce recurrence and progression in people with NMIBC following TUR, however many people do not respond to treatment, have recurrence shortly after, or cannot tolerate standard-dose therapy. The potential for synergistic antitumour activity of interferon (IFN)-alpha (α) and BCG provides some rationale for combination therapy for people who do not tolerate or respond to standard-dose BCG therapy...
March 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28264718/exploring-the-floristic-diversity-of-tropical-africa
#5
Marc S M Sosef, Gilles Dauby, Anne Blach-Overgaard, Xander van der Burgt, Luís Catarino, Theo Damen, Vincent Deblauwe, Steven Dessein, John Dransfield, Vincent Droissart, Maria Cristina Duarte, Henry Engledow, Geoffrey Fadeur, Rui Figueira, Roy E Gereau, Olivier J Hardy, David J Harris, Janneke de Heij, Steven Janssens, Yannick Klomberg, Alexandra C Ley, Barbara A Mackinder, Pierre Meerts, Jeike L van de Poel, Bonaventure Sonké, Tariq Stévart, Piet Stoffelen, Jens-Christian Svenning, Pierre Sepulchre, Rainer Zaiss, Jan J Wieringa, Thomas L P Couvreur
BACKGROUND: Understanding the patterns of biodiversity distribution and what influences them is a fundamental pre-requisite for effective conservation and sustainable utilisation of biodiversity. Such knowledge is increasingly urgent as biodiversity responds to the ongoing effects of global climate change. Nowhere is this more acute than in species-rich tropical Africa, where so little is known about plant diversity and its distribution. In this paper, we use RAINBIO - one of the largest mega-databases of tropical African vascular plant species distributions ever compiled - to address questions about plant and growth form diversity across tropical Africa...
March 7, 2017: BMC Biology
https://www.readbyqxmd.com/read/28257477/wealth-household-heterogeneity-and-livelihood-diversification-of-fulani-pastoralists-in-the-kachia-grazing-reserve-northern-nigeria-during-a-period-of-social-transition
#6
Marie J Ducrotoy, Crawford W Revie, Alexandra P M Shaw, Usman B Musa, Wilson J Bertu, Amahyel M Gusi, Reuben A Ocholi, Ayodele O Majekodunmi, Susan C Welburn
BACKGROUND: A mixed methods study was undertaken in the Kachia Grazing Reserve of northern Nigeria. Surveys in March, June and October 2011 included focus group discussions, key informant and in-depth household interviews, concerning livelihood practices, animal health, ownership, and productivity. In May 2011, 249 Fulani families fleeing post-election violence entered the reserve with their livestock, increasing the number of households by one third. RESULTS: Despite being settled within a grazing reserve, over half of households sent all their cattle away on seasonal transhumance and another third sent some away...
2017: PloS One
https://www.readbyqxmd.com/read/28248987/why-do-people-use-electronic-nicotine-delivery-systems-electronic-cigarettes-a-content-analysis-of-twitter-2012-2015
#7
John W Ayers, Eric C Leas, Jon-Patrick Allem, Adrian Benton, Mark Dredze, Benjamin M Althouse, Tess B Cruz, Jennifer B Unger
The reasons for using electronic nicotine delivery systems (ENDS) are poorly understood and are primarily documented by expensive cross-sectional surveys that use preconceived close-ended response options rather than allowing respondents to use their own words. We passively identify the reasons for using ENDS longitudinally from a content analysis of public postings on Twitter. All English language public tweets including several ENDS terms (e.g., "e-cigarette" or "vape") were captured from the Twitter data stream during 2012 and 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28197532/using-global-gene-expression-to-discriminate-thin-melanomas-with-poor-outcomes
#8
Zachary Hothem, Andrew Bayci, Bryan J Thibodeau, Billie E Ketelsen, Laura E Fortier, Alison F Uzieblo, Diane Cosner, Kristin Totoraitis, Richard D Keidan, George D Wilson
Most melanomas present as thin lesions (≤1.0 mm) with a good prognosis; however, a small percentage of patients with thin lesions experience recurrence or metastasis. The aim of our study was to identify a distinct pattern of gene expression within thin melanomas known to have eventually metastasized to regional lymph nodes or distant sites compared with those that followed the typical course with good response to wide local excision alone. Patients who were disease-free for a minimum of 10 y served as controls (n = 10) to the experimental group who developed metastasis (n = 9)...
2017: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/28187000/malat1-is-a-prognostic-factor-in-glioblastoma-multiforme-and-induces-chemoresistance-to-temozolomide-through-suppressing-mir-203-and-promoting-thymidylate-synthase-expression
#9
Wei Chen, Xin-Ke Xu, Jun-Liang Li, Kuan-Kei Kong, Hui Li, Cheng Chen, Jing He, Fangyu Wang, Ping Li, Xiao-Song Ge, Fang-Cheng Li
Glioblastoma multiforme (GBM) is the most malignant brain tumor with limited therapeutic options. Temozolomide (TMZ) is a novel cytotoxic agent used as first-line chemotherapy for GBM, however, some individual cells can't be isolated for surgical resection and show treatment-resistance, thus inducing poor prognosis. By using the HiSeq sequencing and bioinformatics methods, we identified lncRNAs showing different expression levels in TMZ-resistant and non-resistant patients. RT-qPCR was then performed in tissues and serum samples, and lncRNA MALAT1 was finally identified to show considerable discriminating potential to identify responding patients from non-responding patients...
February 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28185581/does-decentralization-influence-efficiency-of-health-units-a-study-of-opinion-and-perception-of-health-workers-in-odisha
#10
Bhuputra Panda, Harshad P Thakur, Sanjay P Zodpey
BACKGROUND: Health systems in low and middle income countries are struggling to improve efficiency in the functioning of health units of which workforce is one of the most critical building blocks. In India, Rogi Kalyan Samiti (RKS) was established at every health unit as institutions of local decision making in order to improve productive efficiency and quality. Measuring efficiency of health units is a complex task. This study aimed at assessing the perception (opinion and satisfaction) of health workers about influence of RKS on improving efficiency of peripheral decision making health units (DMHU); examining differences between priority and non-priority set-ups; identifying predictors of satisfaction at work; and discussing suggestions to improve performance...
October 31, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/28171709/long-term-outcomes-for-patients-with-chronic-lymphocytic-leukemia-who-discontinue-ibrutinib
#11
Preetesh Jain, Philip A Thompson, Michael Keating, Zeev Estrov, Alessandra Ferrajoli, Nitin Jain, Hagop Kantarjian, Jan A Burger, Susan O'Brien, William G Wierda
BACKGROUND: Ibrutinib is a Bruton tyrosine kinase inhibitor and is approved for the treatment of patients with chronic lymphocytic leukemia (CLL) in frontline and relapsed/refractory settings. The authors previously reported poor outcomes for patients who discontinued ibrutinib; however, long-term outcomes were not reported. METHODS: Data from 320 patients who received ibrutinib on clinical studies between 2010 and 2015 at The University of Texas MD Anderson Cancer Center were retrospectively analyzed...
February 7, 2017: Cancer
https://www.readbyqxmd.com/read/28169420/parents-and-informal-caregivers-views-and-experiences-of-communication-about-routine-childhood-vaccination-a-synthesis-of-qualitative-evidence
#12
REVIEW
Heather Mr Ames, Claire Glenton, Simon Lewin
BACKGROUND: Childhood vaccination is an effective way to prevent serious childhood illnesses, but many children do not receive all the recommended vaccines. There are various reasons for this; some parents lack access because of poor quality health services, long distances or lack of money. Other parents may not trust vaccines or the healthcare workers who provide them, or they may not see the need for vaccination due to a lack of information or misinformation about how vaccinations work and the diseases they can prevent...
February 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28167913/targeting-membrane-lipid-a-potential-cancer-cure
#13
Loh Teng-Hern Tan, Kok-Gan Chan, Priyia Pusparajah, Wai-Leng Lee, Lay-Hong Chuah, Tahir Mehmood Khan, Learn-Han Lee, Bey-Hing Goh
Cancer mortality and morbidity is projected to increase significantly over the next few decades. Current chemotherapeutic strategies have significant limitations, and there is great interest in seeking novel therapies which are capable of specifically targeting cancer cells. Given that fundamental differences exist between the cellular membranes of healthy cells and tumor cells, novel therapies based on targeting membrane lipids in cancer cells is a promising approach that deserves attention in the field of anticancer drug development...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28161583/cumulative-exposure-to-work-related-traumatic-events-and-current-post-traumatic-stress-disorder-in-new-york-city-s-first-responders
#14
Lupo Geronazzo-Alman, Ruth Eisenberg, Sa Shen, Cristiane S Duarte, George J Musa, Judith Wicks, Bin Fan, Thao Doan, Guia Guffanti, Michaeline Bresnahan, Christina W Hoven
BACKGROUND AND OBJECTIVES: Cumulative exposure to work-related traumatic events (CE) is a foreseeable risk for psychiatric disorders in first responders (FRs). Our objective was to examine the impact of work-related CE that could serve as predictor of posttraumatic stress disorder (PTSD) and/or depression in FRs. DESIGN: Cross-sectional examination of previous CE and past-month PTSD outcomes and depression in 209 FRs. METHODS: Logistic (probable PTSD; probable depression) and Poisson regressions (PTSD score) of the outcomes on work-related CE indexes, adjusting for demographic variables...
April 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28157297/identifying-functional-cysteine-residues-in-the-mitochondria
#15
Daniel W Bak, Mattia D Pizzagalli, Eranthie Weerapana
The mitochondria are dynamic organelles that regulate oxidative metabolism and mediate cellular redox homeostasis. Proteins within the mitochondria are exposed to large fluxes in the surrounding redox environment. In particular, cysteine residues within mitochondrial proteins sense and respond to these redox changes through oxidative modifications of the cysteine thiol group. These oxidative modifications result in a loss in cysteine reactivity, which can be monitored using cysteine-reactive chemical probes and quantitative mass spectrometry (MS)...
February 15, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28153865/mechanisms-creating-transient-and-sustained-photoresponses-in-mammalian-retinal-ganglion-cells
#16
Xiwu Zhao, Aaron N Reifler, Melanie M Schroeder, Elizabeth R Jaeckel, Andrew P Chervenak, Kwoon Y Wong
Retinal neurons use sustained and transient light responses to encode visual stimuli of different frequency ranges, but the underlying mechanisms remain poorly understood. In particular, although earlier studies in retinal ganglion cells (RGCs) proposed seven potential mechanisms, all seven have since been disputed, and it remains unknown whether different RGC types use different mechanisms or how many mechanisms are used by each type. Here, we conduct a comprehensive survey in mice and rats of 12 candidate mechanisms that could conceivably produce tonic rod/cone-driven ON responses in intrinsically photosensitive RGCs (ipRGCs) and transient ON responses in three types of direction-selective RGCs (TRHR+, Hoxd10+ ON, and Hoxd10+ ON-OFF cells)...
March 6, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28135303/microrna-and-mrna-transcriptome-profiling-in-primary-human-astrocytes-infected-with-borrelia-burgdorferi
#17
Timothy Casselli, Humaira Qureshi, Elizabeth Peterson, Danielle Perley, Emily Blake, Bradley Jokinen, Ata Abbas, Sergei Nechaev, John A Watt, Archana Dhasarathy, Catherine A Brissette
Lyme disease is caused by infection with the bacterium Borrelia burgdorferi (Bb), which is transmitted to humans by deer ticks. The infection manifests usually as a rash and minor systemic symptoms; however, the bacteria can spread to other tissues, causing joint pain, carditis, and neurological symptoms. Lyme neuroborreliosis presents itself in several ways, such as Bell's palsy, meningitis, and encephalitis. The molecular basis for neuroborreliosis is poorly understood. Analysis of the changes in the expression levels of messenger RNAs and non-coding RNAs, including microRNAs, following Bb infection could therefore provide vital information on the pathogenesis and clinical symptoms of neuroborreliosis...
2017: PloS One
https://www.readbyqxmd.com/read/28111608/repairing-the-aged-parkinsonian-striatum-lessons-from-the-lab-and-clinic
#18
Natosha M Mercado, Timothy J Collier, Thomas Freeman, Kathy Steece-Collier
The primary risk factor associated with Parkinson's disease (PD) is advanced age. While there are symptomatic therapies for PD, efficacy of these eventually wane and/or side-effects develop over time. An alternative experimental therapy that has received a great deal of attention over the past several decades has been neural transplantation aimed at replacing nigral dopamine (DA) neurons that degenerate in PD. However, in PD patients and parkinsonian rats, advanced age is associated with inferior benefit following intrastriatal grafting of embryonic DA neurons...
December 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/28109009/using-flow-characteristics-in-three-dimensional-power-doppler-ultrasound-imaging-to-predict-complete-responses-in-patients-undergoing-neoadjuvant-chemotherapy
#19
Wei-Chung Shia, Yu-Len Huang, Hwa-Koon Wu, Dar-Ren Chen
OBJECTIVES: Strategies are needed for the identification of a poor response to treatment and determination of appropriate chemotherapy strategies for patients in the early stages of neoadjuvant chemotherapy for breast cancer. We hypothesize that power Doppler ultrasound imaging can provide useful information on predicting response to neoadjuvant chemotherapy. METHODS: The solid directional flow of vessels in breast tumors was used as a marker of pathologic complete responses (pCR) in patients undergoing neoadjuvant chemotherapy...
January 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28100256/transcriptomic-signatures-differentiate-survival-from-fatal-outcomes-in-humans-infected-with-ebola-virus
#20
Xuan Liu, Emily Speranza, César Muñoz-Fontela, Sam Haldenby, Natasha Y Rickett, Isabel Garcia-Dorival, Yongxiang Fang, Yper Hall, Elsa-Gayle Zekeng, Anja Lüdtke, Dong Xia, Romy Kerber, Ralf Krumkamp, Sophie Duraffour, Daouda Sissoko, John Kenny, Nichola Rockliffe, E Diane Williamson, Thomas R Laws, Magassouba N'Faly, David A Matthews, Stephan Günther, Andrew R Cossins, Armand Sprecher, John H Connor, Miles W Carroll, Julian A Hiscox
BACKGROUND: In 2014, Western Africa experienced an unanticipated explosion of Ebola virus infections. What distinguishes fatal from non-fatal outcomes remains largely unknown, yet is key to optimising personalised treatment strategies. We used transcriptome data for peripheral blood taken from infected and convalescent recovering patients to identify early stage host factors that are associated with acute illness and those that differentiate patient survival from fatality. RESULTS: The data demonstrate that individuals who succumbed to the disease show stronger upregulation of interferon signalling and acute phase responses compared to survivors during the acute phase of infection...
January 19, 2017: Genome Biology
keyword
keyword
97413
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"