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https://www.readbyqxmd.com/read/29317937/evaluating-the-potential-for-pharmacists-to-prescribe-oral-anticoagulants-for-atrial-fibrillation
#1
Roopinder K Sandhu, Lisa M Guirguis, Tammy J Bungard, Erik Youngson, Lisa Dolovich, Jamie C Brehaut, Jeff S Healey, Finlay A McAlister
Background: Oral anticoagulant therapy (OAC) to prevent atrial fibrillation (AF)-related strokes remains poorly used. Alternate strategies, such as community pharmacist prescribing of OAC, should be explored. Methods: Approximately 400 pharmacists, half with additional prescribing authority (APA), randomly selected from the Alberta College of Pharmacists, were invited to participate in an online survey over a 6-week period. The survey consisted of demographics, case scenarios assessing appropriateness of OAC (based on the 2014 Canadian Cardiovascular Society AF guidelines) and perceived barriers to prescribing...
January 2018: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/29306829/functional-diversity-measures-revealed-impacts-of-non-native-species-and-habitat-degradation-on-species-poor-freshwater-fish-assemblages
#2
Nicole Colin, Sébastien Villéger, Martin Wilkes, Adolfo de Sostoa, Alberto Maceda-Veiga
Trait-based ecology has been developed for decades to infer ecosystem responses to stressors based on the functional structure of communities, yet its value in species-poor systems is largely unknown. Here, we used an extensive dataset in a Spanish region highly prone to non-native fish invasions (15 catchments, N=389 sites) to assess for the first time how species-poor communities respond to large-scale environmental gradients using a taxonomic and functional trait-based approach in riverine fish. We examined total species richness and three functional trait-based indices available when many sites have ≤3 species (specialization, FSpe; originality, FOri and entropy, FEnt)...
January 4, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29302851/lifestyle-related-attitudes-do-they-explain-self-rated-health-and-life-satisfaction
#3
A Simon Pickard, Yash J Jalundhwala, Helen Bewsher, Lisa K Sharp, Surrey M Walton, Glen T Schumock, Rachel N Caskey
BACKGROUND: Strategies to improve public health may benefit from targeting specific lifestyles associated with poor health behaviors and outcomes. The aim of this study was to characterize and examine the relationship between health and lifestyle-related attitudes (HLAs) and self-rated health and life-satisfaction. METHODS: Secondary analyses were conducted on data from a 2012 community wellness survey in Kirklees, UK. Using a validated HLA tool, respondents (n = 9130) were categorized into five segments: health conscious realists (33%), balanced compensators (14%), live-for-todays (18%), hedonistic immortals (10%), and unconfident fatalists (25%)...
January 4, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29302536/birth-preparedness-and-complication-readiness-in-pregnant-women-attending-urban-tertiary-care-hospital
#4
Vasundhara Kamineni, Anuradha D Murki, Venkata Lakshmi Kota
Background: Birth preparedness and complication readiness (BP/CR) is a strategy to promote the timely use of skilled maternal and neonatal care and is based on the theory that preparing for childbirth and being ready for complications reduce delay in obtaining care. Study Objective: The objective of this study was to evaluate the incidence and predictors of birth preparedness, knowledge on danger signs, and emergency readiness among pregnant women attending outpatient clinic of a tertiary care hospital...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29285357/utility-of-chemoradioselection-for-the-optimization-of-treatment-intensity-in-advanced-hypopharyngeal-and-laryngeal-carcinoma
#5
Muneyuki Masuda, Takahiro Wakasaki, Satoshi Toh, Yoshinori Uchida, Hidefumi Rikimaru, Naonobu Kunitake, Yuichiro Higaki
Definitive concomitant chemoradiotherapy (CRT) with high-dose cis-platinum (CDDP) is a current standard protocol for advanced laryngeal and hypopharyngeal cancer sparing surgery for salvage. However, this modality is associated with limited feasibility and frequent sever toxicities. In the present study, a 'chemoradioselection' protocol with minimal toxicity was developed using initial response to CRT as a biomarker for patient selection. Between 2000, March and 2012, September 123 patients with stage III (44), IV (79) laryngeal (64) and hypopharyngeal carcinoma (59) excluding T4 cases were enrolled to this protocol...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29284504/self-help-and-help-seeking-for-communication-disability-in-ghana-implications-for-the-development-of-communication-disability-rehabilitation-services
#6
Karen Wylie, Lindy McAllister, Bronwyn Davidson, Julie Marshall, Clement Amponsah, Josephine Ohenewa Bampoe
BACKGROUND: In low and middle-income countries, such as Ghana, communication disability is poorly recognised and rehabilitation services for people with communication disability are limited. As rehabilitation services for communication disability develop, and the profession of speech-language pathology grows, it is important to consider how services can most appropriately respond to the needs and preferences of the community. Understanding the ways in which people currently self-help and seek help for communication disability is central to developing services that build on existing local practices and are relevant to the community...
December 29, 2017: Globalization and Health
https://www.readbyqxmd.com/read/29283992/common-genes-associated-with-antidepressant-response-in-mouse-and-man-identify-key-role-of-glucocorticoid-receptor-sensitivity
#7
Tania Carrillo-Roa, Christiana Labermaier, Peter Weber, David P Herzog, Caleb Lareau, Sara Santarelli, Klaus V Wagner, Monika Rex-Haffner, Daniela Harbich, Sebastian H Scharf, Charles B Nemeroff, Boadie W Dunlop, W Edward Craighead, Helen S Mayberg, Mathias V Schmidt, Manfred Uhr, Florian Holsboer, Inge Sillaber, Elisabeth B Binder, Marianne B Müller
Response to antidepressant treatment in major depressive disorder (MDD) cannot be predicted currently, leading to uncertainty in medication selection, increasing costs, and prolonged suffering for many patients. Despite tremendous efforts in identifying response-associated genes in large genome-wide association studies, the results have been fairly modest, underlining the need to establish conceptually novel strategies. For the identification of transcriptome signatures that can distinguish between treatment responders and nonresponders, we herein submit a novel animal experimental approach focusing on extreme phenotypes...
December 2017: PLoS Biology
https://www.readbyqxmd.com/read/29280508/does-freeze-all-policy-affect-ivf-outcomes-in-poor-responders
#8
Matheus Roque, Marcello Valle, Marcos Sampaio, Selmo Geber
OBJECTIVES: To evaluate whether the freeze-all strategy affects in vitro fertilization (IVF) outcomes in poor ovarian responders following the Bologna criteria. METHODS: We performed a retrospective cohort study conducted between January 2012 and December 2016. A total of 433 poor responders (per the Bologna criteria) fulfilled the inclusion/exclusion criteria and were included in the study, with 277 patients included in the fresh group and 156 in the freeze-all group...
December 27, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29260592/how-do-aggregated-patient-reported-outcome-measures-data-stimulate-health-care-improvement-a-realist-synthesis
#9
Joanne Greenhalgh, Sonia Dalkin, Elizabeth Gibbons, Judy Wright, Jose Maria Valderas, David Meads, Nick Black
Objectives Internationally, there has been considerable debate about the role of data in supporting quality improvement in health care. Our objective was to understand how, why and in what circumstances the feedback of aggregated patient-reported outcome measures data improved patient care. Methods We conducted a realist synthesis. We identified three main programme theories underlying the use of patient-reported outcome measures as a quality improvement strategy and expressed them as nine 'if then' propositions...
January 1, 2017: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/29241455/inclusion-of-men-in-maternal-and-safe-motherhood-services-in-inner-city-communities-in-ghana-evidence-from-a-descriptive-cross-sectional-survey
#10
Margaret Duah Atuahene, Sylvia Arde-Acquah, Nana Frema Atuahene, Martin Adjuik, John Kuumuori Ganle
BACKGROUND: There has been a growing realisation of the need to enhance men's inclusion in maternal and safe motherhood services, especially in low-income settings. However, empirical studies on the extent to which men are involved in maternal and safe motherhood services especially in poor inner-city communities are lacking. The purpose of this study was to describe the level of men's inclusion in maternal and safe-motherhood services in inner-city communities in Ghana, and to assess the barriers of men's involvement...
December 14, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29241371/capitalizing-on-technology-for-developing-communication-skills-in-autism-spectrum-disorder-a-single-case-study
#11
Veena Mohan, Suja Kurian Kunnath, Vineetha Sara Philip, Lakshmi Santha Mohan, Neethu Thampi
PURPOSE: In this case study, we discuss the application of a patient-centred clinical approach that led to the use of an assisted communication platform to combat severe communicative deficit in a child with autism spectrum disorder (ASD). METHODS: Initial assessment at four years of age revealed that the patient had rudimentary communication skills, with significant sensory integration dysfunction manifested as oral, olfactory, and tactile seeking behaviours; self-stimulatory behaviour; and complete dependence on caregiver for activities of daily living...
December 15, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29219919/financial-impact-of-colorectal-cancer-and-its-consequences-associations-between-cancer-related-financial-stress-and-strain-and-health-related-quality-of-life
#12
Linda Sharp, Eamonn O'Leary, Alan O'Ceilleachair, Mairead Skally, Paul Hanly
BACKGROUND: The financial impact and consequences of cancer on the lives of survivors remain poorly understood. This is especially true for colorectal cancer. OBJECTIVE: We investigated objective cancer-related financial stress, subjective cancer-related financial strain, and their association with health-related quality of life in colorectal cancer survivors. DESIGN: This was a cross-sectional postal survey. SETTINGS: The study was conducted in Ireland, which has a mixed public-private healthcare system...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29218366/haploidentical-natural-killer-cells-induce-remissions-in-non-hodgkin-lymphoma-patients-with-low-levels-of-immune-suppressor-cells
#13
Veronika Bachanova, Dhifaf Sarhan, Todd E DeFor, Sarah Cooley, Angela Panoskaltsis-Mortari, Bruce R Blazar, Julie M Curtsinger, Linda Burns, Daniel J Weisdorf, Jeffrey S Miller
We report a novel phase 2 clinical trial in patients with poor prognosis refractory non-Hodgkin lymphoma (NHL) testing the efficacy of haploidentical donor natural killer (NK) cell therapy (NK dose 0.5-3.27 × 107 NK cells/kg) with rituximab and IL-2 (clinicaltrials.gov NCT01181258). Therapy was tolerated without graft-versus-host disease, cytokine release syndrome, or neurotoxicity. Of 14 evaluable patients, 4 had objective responses (29%; 95% CI 12-55%) at 2 months: 2 had complete response lasting 3 and 9 months...
December 7, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29199023/the-current-status-and-future-role-of-the-phosphoinositide-3-kinase-akt-signaling-pathway-in-urothelial-cancer-an-old-pathway-in-the-new-immunotherapy-era
#14
REVIEW
Sandy T Liu, Gavin Hui, Colleen Mathis, Karim Chamie, Allan J Pantuck, Alexandra Drakaki
The phosphoinositide 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is a well studied signaling pathway that regulates diverse cellular functions including proliferation, metabolism, and transcription. Aberrant activation of this pathway has been implicated in multiple cancers. Genomic studies have shown that activating mutations in oncogenes as well as inactivating mutations in tumor suppressor genes are present across a variety of malignancies, including urothelial carcinoma...
November 3, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29178106/-the-level-of-knowledge-regarding-the-concept-of-brain-death-among-undergraduates-at-the-universitat-de-lleida
#15
P Rivera, F Purroy
INTRODUCTION: Brain death is a death situation which is diagnosed by means of neurological criteria and is the ideal situation for organ donation, as, thanks to intensive care, the organs maintain their viability. Very few studies have analysed the knowledge that the population has about this situation. AIM: To determine how much university students know about brain death by comparing the results between undergraduates pursuing a degree in medicine and those on other bachelor's degree courses...
December 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/29171015/dental-health-care-service-utilisation-and-its-determinants-in-west-iran-a-cross-sectional-study
#16
Satar Rezaei, Abraha Woldemichael, Hamed Zandian, Enayatollah Homaie Rad, Navid Veisi, Behzad Karami Matin
BACKGROUND: Dental health care is not only an effective strategy for the prevention, early diagnosis and treatment of oral diseases but also contributes to the general health of communities. This study aimed to investigate the situation of dental health-care service utilisation and its determinants in Kermanshah city, western Iran, in 2015. METHODS AND MATERIALS: A cross-sectional study on a total of 894 household heads was conducted. The participants were selected using a multistage sampling technique...
November 23, 2017: International Dental Journal
https://www.readbyqxmd.com/read/29161375/health-system-factors-affecting-implementation-of-integrated-management-of-childhood-illness-imci-qualitative-insights-from-a-south-african-province
#17
Himani Pandya, Wiedaad Slemming, Haroon Saloojee
The Integrated Management of Childhood Illness (IMCI) strategy has been adopted by 102 countries including South Africa, as the preferred primary health care (PHC) delivery strategy for sick children under 5 years. Despite substantial investment to support IMCI in South Africa, its delivery remains sub-optimal, with varied implementation in different settings. There is scarce research globally, and in the local context, examining the effects of health system characteristics on IMCI implementation. This study explored key determinants of IMCI delivery in a South African province, with a specific focus on health system building blocks using a health system dynamics framework...
November 17, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29155825/poverty-and-health-among-cdc-plantation-labourers-in-cameroon-perceptions-challenges-and-coping-strategies
#18
Valerie Makoge, Lenneke Vaandrager, Harro Maat, Maria Koelen
Creating better access to good quality healthcare for the poor is a major challenge to development. In this study, we examined inter-linkages between poverty and disease, referred to as poverty-related diseases (PRDs), by investigating how Cameroon Development Corporation (CDC) camp dwellers respond to diseases that adversely affect their health and wellbeing. Living in plantation camps is associated with poverty, overcrowding, poor sanitation and the rapid spread of diseases. In a survey of 237 CDC camp dwellers in Cameroon, we used the health belief model to understand the drivers (perceived threats, benefits and cues for treatment seeking) of reported responses...
November 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29153154/a-100-year-review-from-ascorbic-acid-to-zinc-mineral-and-vitamin-nutrition-of-dairy-cows
#19
W P Weiss
Mineral and vitamin nutrition of dairy cows was studied before the first volume of the Journal of Dairy Science was published and is still actively researched today. The initial studies on mineral nutrition of dairy cows were simple balance experiments (although the methods available at the time for measuring minerals were anything but simple). Output of Ca and P in feces, urine, and milk was subtracted from intake of Ca and P, and if values were negative it was often assumed that cows were lacking in the particular mineral...
December 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29150228/surgeons-perceptions-of-the-causes-of-preventable-harm-in-arterial-surgery-a-mixed-methods-study
#20
Rachael Lear, Anthony D Godfrey, Celia Riga, Christine Norton, Charles Vincent, Colin D Bicknell
BACKGROUND: System factors contributing to preventable harm in vascular patients have not been previously reported in detail. The aim of this exploratory mixed-methods study was to describe vascular surgeons' perceptions of factors contributing to adverse events (AEs) in arterial surgery. A secondary aim was to report recommendations to improve patient safety. METHODS: Vascular consultants/registrars working in the British National Health Service were questioned about the causes of preventable AEs through survey and semi-structured interview (response rates 77% and 83%, respectively)...
November 15, 2017: European Journal of Vascular and Endovascular Surgery
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