keyword
MENU ▼
Read by QxMD icon Read
search

strategy on poor responder

keyword
https://www.readbyqxmd.com/read/28802776/the-psychosocial-burden-of-psoriatic-arthritis
#1
REVIEW
M Elaine Husni, Joseph F Merola, Sara Davin
OBJECTIVE: To assess the psychosocial impact of psoriatic arthritis (PsA), describe how health-related quality of life (QoL) is affected in patients with PsA, discuss measures used to evaluate the psychosocial impact of PsA, and review studies examining the effect of therapy on QoL. METHODS: A targeted review on the impact of PsA on QoL and the role of tailored psychosocial management in reducing the psychosocial burden of the disease was performed. PubMed literature searches were conducted using the terms PsA, psychosocial burden, QoL, and mood/behavioral changes...
May 20, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28790453/perianal-fistulizing-crohn-s-disease-pathogenesis-diagnosis-and-therapy
#2
REVIEW
Julián Panés, Jordi Rimola
Perianal fistulizing Crohn's disease has a major negative effect on patient quality of life and is a predictor of poor long-term outcomes. Factors involved in the pathogenesis of perianal fistulizing Crohn's disease include an increased production of transforming growth factor β, TNF and IL-13 in the inflammatory infiltrate that induce epithelial-to-mesenchymal transition and upregulation of matrix metalloproteinases, leading to tissue remodelling and fistula formation. Care of patients with perianal Crohn's disease requires a multidisciplinary approach...
August 9, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28777888/sildenafil-for-pulmonary-hypertension-in-neonates
#3
REVIEW
Lauren E Kelly, Arne Ohlsson, Prakeshkumar S Shah
BACKGROUND: Persistent pulmonary hypertension in the neonate (PPHN) is associated with high mortality. Currently, the therapeutic mainstay for PPHN consists of assisted ventilation and administration of inhaled nitric oxide (iNO). However, nitric oxide is costly, and its use may not be appropriate in resource-poor settings. Approximately 30% of patients fail to respond to iNO. High concentrations of phosphodiesterases in the pulmonary vasculature have led to the use of phosphodiesterase inhibitors such as sildenafil or milrinone...
August 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28776785/autonomous-and-continuous-stimuli-responsive-polymer-surface-for-antibacterial-application-via-enzymatic-self-propagating-reactions
#4
Xiaogang Qu, Chao Ding, Zhengqing Yan, Jinsong Ren
Stimuli-responsive polymer materials inspired by biological materials have invoked increasing research interest; however still suffer from limitations such as finite amplified responses and poor sensitivity of the unstimulated parts. Here, we describe a new strategy for creating H+ responsive polymer surfaces that are capable of transforming specific local, fleeting stimuli into global, macroscopic changes. The introduction of self-propagating reactions into the polymer surface systems endows them with excellent stimuli amplification properties and calls up response of the unstimulated parts...
August 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28774715/dendritic-cell-recruitment-and-activation-in-autoimmunity
#5
REVIEW
Silvano Sozzani, Annalisa Del Prete, Daniela Bosisio
Dendritic cells (DCs) are professional antigen presenting cells displaying the unique capability to activate naïve T cells. DCs react to pathogen encounter also by the production of mediators of inflammation, including pro-inflammatory cytokines. Because of this complex role, any imbalance in DC function reflects into defective or exaggerated immune response and tissue damage. DCs comprise two main subsets, namely conventional or classical DCs (cDCs), that are dedicated antigen presenting cells, and plasmacytoid DCs (pDCs), that respond to nucleic acids by releasing high amounts of type I interferons (IFNs)...
July 31, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28757413/restoration-of-mir-30a-expression-inhibits-growth-tumorigenicity-of-medulloblastoma-cells-accompanied-by-autophagy-inhibition
#6
Satishkumar Vishram Singh, Aditi Nigam Dakhole, Akash Deogharkar, Sadaf Kazi, Rohan Kshirsagar, Atul Goel, Aliasgar Moiyadi, Rakesh Jalali, Epari Sridhar, Tejpal Gupta, Prakash Shetty, Nikhil Gadewal, Neelam Vishwanath Shirsat
Medulloblastoma is a highly malignant pediatric brain tumor. About 30% patients have metastasis at diagnosis and respond poorly to treatment. Those that survive, suffer long term neurocognitive, endocrine and developmental defects due to the cytotoxic treatment to developing child brain. It is therefore necessary to develop targeted treatment strategies based on underlying biology for effective treatment of medulloblastoma with minimal side effects. Medulloblastomas are believed to be the result of deregulated nervous system development as evident from the role of WNT and SHH developmental signaling pathways in pathogenesis of medulloblastomas...
July 27, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28756562/life-history-written-in-blood-erythrocyte-parameters-in-a-small-hibernator-the-edible-dormouse
#7
Nadine Havenstein, Franz Langer, Joanna Fietz
The oxygen delivery system is one major determinant of the performance of vertebrates and responds sensitively to a variety of internal and environmental factors. To understand physiological mechanisms underlying variations of fitness, we investigated effects of demanding conditions associated with certain life-history events, food availability, and population density on the oxygen delivery system in free-ranging edible dormice (Glis glis). We sampled blood (n = 248) and urine (n = 319), performed an erythrocyte haemogram and visually determined the presence of haemoglobinuria...
July 29, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28752622/response-to-nitrogen-addition-reveals-metabolic-and-ecological-strategies-of-soil-bacteria
#8
Md Sainur Samad, Charlotte Johns, Karl G Richards, Gary J Lanigan, Cecile A M de Klein, Timothy J Clough, Sergio E Morales
The nitrogen (N) cycle represents one of the most well studied systems yet the taxonomic diversity of the organisms that contribute to it is mostly unknown, or linked to poorly characterized microbial groups. While new information has allowed functional groups to be refined, they still rely on a priori knowledge of enzymes involved, and the assumption of functional conservation, with little connection to the role the transformations plays for specific organisms. Here, we use soil microcosms to test the impact of N deposition on prokaryotic communities...
July 28, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28744266/nutrient-and-rainfall-additions-shift-phylogenetically-estimated-traits-of-soil-microbial-communities
#9
Kelly Gravuer, Anu Eskelinen
Microbial traits related to ecological responses and functions could provide a common currency facilitating synthesis and prediction; however, such traits are difficult to measure directly for all taxa in environmental samples. Past efforts to estimate trait values based on phylogenetic relationships have not always distinguished between traits with high and low phylogenetic conservatism, limiting reliability, especially in poorly known environments, such as soil. Using updated reference trees and phylogenetic relationships, we estimated two phylogenetically conserved traits hypothesized to be ecologically important from DNA sequences of the 16S rRNA gene from soil bacterial and archaeal communities...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28736847/reproductive-plasticity-and-landscape-heterogeneity-benefit-a-ground-nesting-bird-in-a-fire-prone-ecosystem
#10
J Matthew Carroll, Torre J Hovick, Craig A Davis, R Dwayne Elmore, Samuel D Fuhlendorf
Disturbance is critical for the conservation of rangeland ecosystems worldwide and many of these systems are fire dependent. Although it is well established that restoring fire as an ecological process can lead to increased biodiversity in grasslands and shrublands, the underlying mechanisms driving community patterns are poorly understood for fauna in fire-prone landscapes. Much of this uncertainty stems from the paucity of studies that examine the effects of fire at scales relevant to organism life histories...
July 24, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28736184/attitudes-towards-zika-virus-infection-among-medical-doctors-in-aceh-province-indonesia
#11
Harapan Harapan, Alma Alleta, Samsul Anwar, Abdul M Setiawan, Reza Maulana, Nur Wahyuniati, Muhammad R Ramadana, Ikram Ikram, Sotianingsih Haryanto, Kurnia F Jamil, Ulrich Kuch, Alfonso J Rodríguez-Morales
Zika virus (ZIKV) infection, a public health emergency of international concern, has recently been confirmed in Indonesia. However, to date, there has been no study to assess how prepared healthcare workers in Indonesia are to confront this emerging infectious disease. The aim of this study was to assess the attitudes of medical doctors in Indonesia towards ZIKV infection and its associated explanatory variables. A cross-sectional self-administered online survey was conducted from 3 May to 3 June 2016 in Aceh province, Indonesia...
July 20, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28725484/logarithmic-sensing-in-bacillus-subtilis-aerotaxis
#12
Filippo Menolascina, Roberto Rusconi, Vicente I Fernandez, Steven Smriga, Zahra Aminzare, Eduardo D Sontag, Roman Stocker
Aerotaxis, the directed migration along oxygen gradients, allows many microorganisms to locate favorable oxygen concentrations. Despite oxygen's fundamental role for life, even key aspects of aerotaxis remain poorly understood. In Bacillus subtilis, for example, there is conflicting evidence of whether migration occurs to the maximal oxygen concentration available or to an optimal intermediate one, and how aerotaxis can be maintained over a broad range of conditions. Using precisely controlled oxygen gradients in a microfluidic device, spanning the full spectrum of conditions from quasi-anoxic to oxic (60 n mol/l-1 m mol/l), we resolved B...
2017: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/28722599/assessment-of-fecal-exposure-pathways-in-low-income-urban-neighborhoods-in-accra-ghana-rationale-design-methods-and-key-findings-of-the-sanipath-study
#13
Katharine Robb, Clair Null, Peter Teunis, Habib Yakubu, George Armah, Christine L Moe
Rapid urbanization has contributed to an urban sanitation crisis in low-income countries. Residents in low-income, urban neighborhoods often have poor sanitation infrastructure and services and may experience frequent exposure to fecal contamination through a range of pathways. There are little data to prioritize strategies to decrease exposure to fecal contamination in these complex and highly contaminated environments, and public health priorities are rarely considered when planning urban sanitation investments...
July 17, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28721020/access-to-credible-information-on-schizophrenia-patients-medication-adherence-by-prescribers-can-change-their-treatment-strategies-evidence-from-an-online-survey-of-providers
#14
Jason Shafrin, Suepattra G May, Anshu Shrestha, Charles Ruetsch, Nicole Gerlanc, Felicia Forma, Ainslie Hatch, Darius N Lakdawalla, Jean-Pierre Lindenmayer
OBJECTIVE: Overestimating patients' medication adherence diminishes the ability of psychiatric care providers to prescribe the most effective treatment and to identify the root causes of treatment resistance in schizophrenia. This study was conducted to determine how credible patient drug adherence information (PDAI) might change prescribers' treatment decisions. METHODS: In an online survey containing 8 clinical case vignettes describing patients with schizophrenia, health care practitioners who prescribe antipsychotics to patients with schizophrenia were instructed to choose a preferred treatment recommendation from a set of predefined pharmacologic and non-pharmacologic options...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28707451/perceptions-of-key-participants-about-botswana-adolescents-risks-of-unplanned-pregnancy-sexually-transmitted-diseases-and-hiv-qualitative-findings
#15
Mabel K M Magowe, Esther Seloilwe, Kefalotse Dithole, Janet St Lawrence
AIM: The qualitative research findings are reported on the perceptions of key participants in Botswana about adolescent sexuality problems and the feasibility (with suggestions) of an adolescent prevention intervention. METHODS: Twenty adult key participants who were selected through purposive sampling from schools and youth centers responded to open-ended questions during face-to-face individual in-depth interviews that were conducted between December, 2011 and January, 2012 in Gaborone, Botswana...
July 13, 2017: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/28704467/locomotor-adaptability-in-persons-with-unilateral-transtibial-amputation
#16
Benjamin J Darter, Amy J Bastian, Erik J Wolf, Elizabeth M Husson, Bethany A Labrecque, Brad D Hendershot
BACKGROUND: Locomotor adaptation enables walkers to modify strategies when faced with challenging walking conditions. While a variety of neurological injuries can impair locomotor adaptability, the effect of a lower extremity amputation on adaptability is poorly understood. OBJECTIVE: Determine if locomotor adaptability is impaired in persons with unilateral transtibial amputation (TTA). METHODS: The locomotor adaptability of 10 persons with a TTA and 8 persons without an amputation was tested while walking on a split-belt treadmill with the parallel belts running at the same (tied) or different (split) speeds...
2017: PloS One
https://www.readbyqxmd.com/read/28685859/bird-community-responses-to-habitat-creation-in-a-long-term-large-scale-natural-experiment
#17
Robin C Whytock, Elisa Fuentes-Montemayor, Kevin Watts, Patanjaly Barbosa De Andrade, Rory Whytock, Paul French, Nicholas Macgregor, Kirsty J Park
Ecosystem function and resilience are compromised when habitats become fragmented due to land-use change. This has led to national and international conservation strategies aimed at restoring habitat extent and improving functional connectivity (i.e. maintaining dispersal processes). However, biodiversity responses to landscape-scale habitat creation and the relative importance of spatial and temporal scales is poorly understood, and there is disagreement over which conservation strategies should be prioritised...
July 7, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28675065/hypomethylating-agents-hma-treatment-for-myelodysplastic-syndromes-alternatives-in-the-frontline-and-relapse-settings
#18
Natalie Uy, Abhay Singh, Steven D Gore, Thomas Prebet
Hypomethylating agents (HMA) have played a pivotal role for treating myelodysplastic syndromes (MDS) over the past decade, inducing sustained hematological responses and delaying progression to leukemia. However, a vast majority of patients will experience treatment failure within 2 years, with poor prognoses and limited options, and management of this growing patient population remains unclear. Areas covered: With the introduction of new agents in the MDS field, a better understanding of the biology of MDS, and updated information on standard of care options (including allogeneic transplantation), we re-evaluate the global treatment strategy in MDS via novel agents, focusing in particular on investigational approaches for patients who fail to respond to HMA when applicable...
August 1, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28668084/factors-influencing-the-ownership-and-utilization-of-long-lasting-insecticidal-nets-for-malaria-prevention-in-ethiopia
#19
Admasu Tassew, Richard Hopkins, Wakgari Deressa
BACKGROUND: Utilization of long-lasting insecticidal nets (LLINs) is regarded as key malaria prevention and control strategy. However, studies have reported a large gap in terms of both ownership and utilization particularly in the sub-Saharan Africa (SSA). With continual efforts to improve the use of LLIN and to progress malaria elimination, examining the factors influencing the ownership and usage of LLIN is of high importance. Therefore, the current study was conducted to examine the level of ownership and use of LLIN along with identification of associated factors at household level...
July 1, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28660347/bioinspired-magnetic-reception-and-multimodal-sensing
#20
Brian K Taylor
Several animals use Earth's magnetic field in concert with other sensor modes to accomplish navigational tasks ranging from local homing to continental scale migration. However, despite extensive research, animal magnetic reception remains poorly understood. Similarly, the Earth's magnetic field offers a signal that engineered systems can leverage to navigate in environments where man-made positioning systems such as GPS are either unavailable or unreliable. This work uses a behavioral strategy inspired by the migratory behavior of sea turtles to locate a magnetic goal and respond to wind when it is present...
August 2017: Biological Cybernetics
keyword
keyword
97413
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"