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https://www.readbyqxmd.com/read/29240010/well-preserved-renal-function-in-children-with-untreated-chronic-liver-disease
#1
Ulla B Berg, Antal Németh
OBJECTIVES: Based on studies with hepatorenal syndrome, it is widely regarded that renal function is impacted in chronic liver disease. Therefore we investigated renal function in our children with chronic liver disease. METHODS: In a retrospective study of 277 children with chronic liver disease, renal function was investigated as glomerular filtration rate (GFR) and effective renal plasma flow (ERPF), measured as clearance of inulin and para-amino hippuric acid or clearance of iohexol...
December 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29240005/efficacy-of-a-dual-ring-wound-protector-for-prevention-of-surgical-site-infections-after-pancreaticoduodenectomy-in-patients-with-intrabiliary-stents-a-randomized-clinical-trial
#2
Alexsander K Bressan, Jean-Michel Aubin, Guillaume Martel, Elijah Dixon, Oliver F Bathe, Francis R Sutherland, Fady Balaa, Richard Mimeault, Janet P Edwards, Sean C Grondin, Susan Isherwood, Keith D Lillemoe, Sara Saeed, Chad G Ball
OBJECTIVE: To evaluate the efficacy of a dual-ring wound protector for preventing incisional surgical site infection (SSI) among patients with preoperative biliary stents undergoing pancreaticoduodenectomy (PD). METHODS AND ANALYSIS: This study was a parallel, dual-arm, double-blind randomized controlled trial. Adult patients with a biliary stent undergoing elective PD at 2 tertiary care institutions were included (February 2013 to May 2016). Patients were randomly assigned to receive a surgical dual-ring wound protector or no wound protector, and also the current standard of care...
December 12, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29238914/clinical-and-genetic-implications-of-dna-mismatch-repair-deficiency-in-biliary-tract-cancers-associated-with-lynch-syndrome
#3
Jordan M Cloyd, Yun Shin Chun, Naruhiko Ikoma, Jean Nicolas Vauthey, Tlhomas A Aloia, Amanda Cuddy, Miguel A Rodriguez-Bigas, Y Nancy You
PURPOSE: Patients with Lynch syndrome (LS) have a significantly elevated lifetime risk of developing biliary tract cancers (BTCs) compared to the general population. However, few studies have characterized the clinical characteristics, genetic features, or long-term outcomes of mismatch-repair deficient (dMMR) cholangiocarcinomas associated with LS. METHODS: A retrospective review of a prospectively maintained Familial High-Risk GI Cancer Clinic database identified all patients with BTCs evaluated from 2006 to 2016 who carried germline mutations in MLH1, MSH2, MSH6, or PMS2...
December 14, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29234972/staging-treatment-and-future-approaches-of-gallbladder-carcinoma
#4
REVIEW
Sanjeev Kumar Shukla, Govind Singh, K S Shahi, Bhuvan, Prabhat Pant
BACKGROUND: Gallbladder cancer is the most common malignant cancer of the bile ducts and third most common gastrointestinal malignant in the world for public health. Its relatively low incidence and confused symptoms result in advanced disease at the time of presentation, contributing to poor prognosis and reduced survival associated with this disease. The main function of the gallbladder is to store excreted bile acids from the liver in preparation for a meal. Its main risk factor is prolonged exposure to biliary calculations, although bacterial infections and other inflammatory conditions are associated...
December 12, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29232532/reconsideration-of-laparoscopic-kasai-operation-for-biliary-atresia
#5
Sheng-Yang Huang, Chou-Ming Yeh, Hou-Chuan Chen, Chia-Man Chou
INTRODUCTION: Minimal invasive surgery for all kinds of surgical diseases had been practiced for years. The laparoscopic Kasai operation is one of the most challenging procedures and remains controversial for treating biliary atresia (BA). PURPOSE: This work presented the initial experience of our Institute and compared the outcomes of open and laparoscopic Kasai operations for BA. MATERIALS AND METHODS: Patients 18 years old and younger, and were operated in our Institute for BA from January 2011 to August 2017, were included in this study...
December 12, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29229480/liver-transplantation-for-deterioration-in-native-liver-function-after-portoenterostomy-for-biliary-atresia-in-japan-short-versus-long-term-survivors
#6
Takanori Ochi, Hiroki Nakamura, Momoko Wada, Tsuyoshi Tamura, Hiroyuki Koga, Tadaharu Okazaki, Masahiko Urao, Yoichi Ishizaki, Seiji Kawasaki, Mureo Kasahara, Koichi Mizuta, Geoffrey J Lane, Atsuyuki Yamataka
PURPOSE: We reviewed our post-Kasai portoenterostomy biliary atresia (BA) patients who required liver transplantation (LTx) for deterioration in native liver (NL) function to investigate mortality in relation to age at LTx. METHODS: BA patients indicated for LTx when less than 18years old (U18; n=17) and when 18 or older (18+; n=13) were compared. All achieved jaundice clearance postoperatively (TBil ≤1.2mg/dL (≈20μmol/L)). RESULTS: In U18, living-donor (LD) LTxs were performed at a median of 6...
November 13, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29229136/the-gut-liver-axis-impact-of-a-mouse-model-of-small-bowel-bacterial-overgrowth
#7
Qingqing Wang, Bin Wang, Vijay Saxena, Lili Miles, Josh Tiao, Joel E Mortensen, Jaimie D Nathan
BACKGROUND: The mechanisms by which intestinal bacteria impact liver diseases remain poorly understood. The aim of this study was to develop a mouse model of small-bowel bacterial overgrowth and to determine its impact on hepatobiliary injury. MATERIALS AND METHODS: A jejunal self-filling blind loop (SFBL) was created in C57BL/6 mice. Three weeks after surgery, the mice were euthanized, and bacterial cultures of luminal content of the loop and extraintestinal tissues were performed...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29228523/advanced-therapeutic-gastrointestinal-endoscopy-in-children-today-and-tomorrow
#8
Zaheer Nabi, Duvvur Nageshwar Reddy
Gastrointestinal (GI) endoscopy plays an indispensable role in the diagnosis and management of various pediatric GI disorders. While the pace of development of pediatric GI endoscopy has increased over the years, it remains sluggish compared to the advancements in GI endoscopic interventions available in adults. The predominant reasons that explain this observation include lack of formal training courses in advanced pediatric GI interventions, economic constraints in establishing a pediatric endoscopy unit, and unavailability of pediatric-specific devices and accessories...
December 12, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/29228512/surgical-management-decreases-disease-recurrence-risk-in-recurrent-pyogenic-cholangitis
#9
Hwee Leong Tan, Ye Xin Koh, Weng Kit Lye, Ser Yee Lee, Brian Kim Poh Goh, Siong San Tan, Adrian Kah Heng Chiow, Chung Yip Chan
BACKGROUND: Recurrent pyogenic cholangitis (RPC) has a high risk of disease recurrence. We present our experience with RPC and examine the factors associated with disease recurrence. METHODS: We performed a retrospective review of all patients with RPC treated at two tertiary institutions between January 1990 and December 2013. Patients with liver atrophy and/or abscess were categorized as being associated with parenchymal disease (PD). RESULTS: We studied 157 patients with a median age of 59...
December 11, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29226107/cholangitis-diagnosis-treatment-and-prognosis
#10
REVIEW
Amir Houshang Mohammad Alizadeh
Cholangitis is a serious life-threatening situation affecting the hepatobiliary system. This review provides an update regarding the clinical and pathological features of various forms of cholangitis. A comprehensive search was performed in the PubMed, Scopus, and Web of Knowledge databases. It was found that the etiology and pathogenesis of cholangitis are heterogeneous. Cholangitis can be categorized as primary sclerosing (PSC), secondary (acute) cholangitis, and a recently characterized form, known as IgG4-associated cholangitis (IAC)...
December 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/29225328/gallbladder-hypoplasia-a-congenital-abnormality-of-the-gallbladder-a-case-report
#11
Christophoros S Kosmidis, Georgios D Koimtzis, Maria S Kosmidou, Fotini Ieridou, Triantafyllia Koletsa, Katerina T Zarampouka, Eleni Georgakoudi, Isaac Kesisoglou
BACKGROUND There are different variations in the anatomy of the gallbladder. Congenital abnormalities of the gallbladder such as agenesis and hypoplasia are rare conditions and difficult to diagnose with imaging studies. Patients are usually asymptomatic or have symptoms that mimic gallstone disease. The diagnosis is often made intraoperatively and is established by histopathological examination. CASE REPORT We report a case of a 62-year-old male who had cholelithiasis symptoms and was falsely diagnosed with gallstone disease by abdominal ultrasound scan...
December 11, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29225082/comparison-of-eus-with-magnetic-resonance-cholangiopancreatography-in-idiopathic-acute-pancreatitis-a-systematic-review-and-meta-analysis
#12
REVIEW
Jianhua Wan, Yaobin Ouyang, Chen Yu, Xiaoyu Yang, Liang Xia, Nonghua Lu
BACKGROUND: /Aims: Idiopathic acute pancreatitis (IAP) poses a diagnostic challenge for gastroenterologists, as confirmation of the disease etiology has important implications for the selection of the best possible treatment and the prevention of possible recurrence or the development of chronic pancreatitis. ERCP, EUS, and magnetic resonance cholangiopancreatography (MRCP) are typically used to diagnose IAP when conventional radiological methods fail. However, their exact role in the diagnosis of IAP has not yet been determined...
December 7, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29224898/clinical-outcome-of-patients-with-advanced-biliary-tract-cancer-in-a-dedicated-phase-i-unit
#13
R Sundar, A Custodio, A Petruckevich, M Chénard-Poirier, M Ameratunga, D Collins, J Lim, S B Kaye, N Tunariu, U Banerji, J de Bono, J Lopez
AIMS: Advanced biliary tract carcinomas (ABC) are malignancies with limited effective therapies for advanced disease. There is little published evidence of outcomes of ABC patients participating in phase I clinical trials. MATERIALS AND METHODS: Patient characteristics, treatment details and outcomes of ABC patients treated at a dedicated phase I unit were captured and analysed from case and trial records. RESULTS: In total, 123 ABC patients were included in the study, of which 48 patients participated in 41 different phase I trials; 75 (61%) did not participate due to rapid disease progression or patient choice...
December 7, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29224663/obstruction-of-the-biliary-and-urinary-system
#14
William O'Connell, Jay Shah, Jason Mitchell, J David Prologo, Louis Martin, Michael J Miller, Jonathan G Martin
Biliary and urinary obstructions can be managed endoscopically or cystoscopically, surgically or by percutansous intervention or drainage. If the obtructed system is infected, emergent decompression is needed. Early recognition and treatment is paramount in both conditions. Acute cholangitis can present many different ways, from mild symptoms to fulminant sepsis. It is usually a result of ascending bacterial colonization and biliary obstruction resulting in bacterial overgrowth. Therefore, those patients with recent biliary instrumentation or previous biliary modification are at higher risk...
December 2017: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/29220537/milder-disease-stage-in-patients-with-primary-biliary-cholangitis-over-a-44-year-period-a-changing-natural-history
#15
Fiorella Murillo Perez, Jorn C Goet, Willem J Lammers, Aliya Gulamhusein, Henk R van Buuren, Cyriel Y Ponsioen, Marco Carbone, Andrew Mason, Christophe Corpechot, Pietro Invernizzi, Marlyn J Mayo, Pier Maria Battezzati, Annarosa Floreani, Albert Pares, Frederik Nevens, Kris V Kowdley, Tony Bruns, George N Dalekos, Douglas Thorburn, Gideon Hirschfield, Nicholas F LaRusso, Keith D Lindor, Kalliopi Zachou, Raoul Poupon, Palak J Trivedi, Xavier Verhelst, Harry L A Janssen, Bettina E Hansen
Changes over time in the presenting features and clinical course of patients with primary biliary cholangitis (PBC) are poorly described. We sought to describe temporal trends in patient and disease characteristics over a 44-year period across a large international PBC cohort of 4805 patients diagnosed between 1970 and 2014, from 17 centers across Europe and North America. Patients were divided into five cohorts according to their year of diagnosis: 1970-1979 (n=143), 1980-1989 (n=858), 1990-1999 (n=1754), 2000-2009 (n=1815), ≥2010 (n=235)...
December 8, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29220096/hepatic-progenitor-cells-in-metastatic-liver-carcinomas
#16
Ioanna Delladetsima, Stratigoula Sakellariou, Olivier Govaere, Elpida Poulaki, Evangelos Felekouras, Dina Tiniakos
AIMS: Hepatic progenitor cells (HPCs) are activated in various liver diseases but their role in carcinomatous environment remains unknown. We aimed to identify the possible presence and topography of HPCs in liver metastases. METHODS: We examined 14 liver resection specimens for colorectal adenocarcinoma (CRC) (n=13) and anal squamous cell carcinoma (SCC) (n=1) metastases. Immunohistochemical markers of colonic (keratin 20-K20, CDX2) and squamous cell origin (p63), HPC (K19, CD56) and stem cell (CD44) markers, and the biliary marker K7 which may also highlight HPCs were applied on routinely processed tissue sections...
December 8, 2017: Histopathology
https://www.readbyqxmd.com/read/29216022/yield-of-endoscopic-ultrasound-in-children-and-adolescent-with-acute-recurrent-pancreatitis
#17
Sumit Kumar Singh, Anshu Srivastava, Praveer Rai, Surender K Yachha, Ujjal Poddar
OBJECTIVES: Endoscopic ultrasound (EUS) is an established tool for evaluation of adults with acute recurrent pancreatitis (ARP) while data in pediatrics is limited. Our study assessed the role of EUS in identifying etiology including changes of chronic pancreatitis (CP) in children and adolescents with ARP. METHODS: Children with ARP (≥2 episodes of acute pancreatitis) were prospectively evaluated with a detailed clinical proforma and EUS. Subjects with known etiology of ARP or CP on ultrasonography/computed tomography and magnetic resonance cholangio-pancreatography (MRCP, Cambridge grade ≥3) were excluded...
December 5, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29216021/long-term-results-and-quality-of-life-assessment-in-biliary-atresia-patients-a-35-year-experience-in-a-tertiary-hospital
#18
Carol Wing Yan Wong, Patrick Ho Yu Chung, Paul Kwong Hang Tam, Kenneth Kak Yuen Wong
OBJECTIVES: To review long-term transplant-free survival and quality of life of patients with biliary atresia. METHODS: A retrospective study reviewing all patients with Kasai operation between 1 January 1980 and 31 December 2015 was performed to evaluate the transplant-free survival. Subgroup analysis of patients over 20 years old was carried out to assess the quality of life using the Short Form-36 Health Survey and incidences of disease-related complications...
December 5, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29213001/-resumption-of-enteral-nutrition-using-enteral-formula-containing-sodium-alginate-following-hemorrhaging-after-endoscopic-sphincterotomy-a-case-report
#19
Tetsuro Akashi, Kazuhide Matsumoto, Risa Hashimoto, Naomi Koikawa, Masaki Yamada, Junko Shimizu, Chisato Kakegawa, Mari Nakamura, Chieko Kumamoto
Enteral nutrition is often performed in elderly patients with dysphagia. Choledocholithiasis is a disease that is common in elderly patients. Gastrointestinal hemorrhaging can occur in association with endoscopic sphincterotomy, and subsequent enteral nutrition must be carefully resumed. We herein report our experience using Mermed Plus containing sodium alginate after endoscopic hemostasis. The patient was an 88-year-old woman with an onset of gallstone cholangitis during rehabilitation after cerebral infarction...
2017: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/29212771/establishment-of-a-surgical-bile-duct-injection-technique-giving-direct-access-to-the-bile-ducts-for-studies-of-the-murine-biliary-tree
#20
Natalie Lie Berntsen, Bjarte Fosby, Laura Valestrand, Corey Tan, Henrik Reims, Elisabeth Schrumpf, Tom H Karlsen, Pål-Dag Line, Espen Melum
Cholangiopathies are progressive disorders with largely unknown pathoetiology and limited treatment options. We aimed to develop a novel surgical technique with direct access to the bile ducts that would complement existing mouse models of cholestasis, biliary inflammation and fibrosis, and present a new route of administration for testing of potential treatment strategies. We developed a surgical technique to access the murine biliary tree by injection of different solvents through catheterization of the gall bladder with simultaneous clamping of the common bile duct...
December 6, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
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