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Idiopathic anaphylaxis

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https://www.readbyqxmd.com/read/28629749/a-distinct-biomolecular-profile-identifies-monoclonal-mast-cell-disorders-in-patients-with-idiopathic-anaphylaxis
#1
Melody C Carter, Avanti Desai, Hirsh D Komarow, Yun Bai, Sarah T Clayton, Alicia S Clark, Karina N Ruiz-Esteves, Lauren M Long, Daly Cantave, Todd M Wilson, Linda M Scott, Olga Simakova, Mi-Yeon Jung, Jamie Hahn, Irina Maric, Dean D Metcalfe
BACKGROUND: Clonal mast cell disorders are known to occur in a subset of patients with systemic reactions to Hymenoptera stings. This observation has prompted the question as to whether clonal mast cell disorders also occur in patients with idiopathic anaphylaxis (IA). OBJECTIVE: We sought to determine the prevalence of clonal mast cell disorders among patients with IA, criteria to identify those patients who require a bone marrow biopsy and whether the pathogenesis of IA involves a hyper-responsive mast cell compartment...
June 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28583235/type-1-kounis-syndrome-in-a-patient-with-idiopathic-anaphylaxis
#2
Monica Sandhu, Jason Casselman, Brian Peppers, Haig Tcheurekdjian, Robert W Hostoffer
Anaphylactic insults that cause cardiovascular signs and symptoms have been defined as Kounis syndrome, which has been associated with specific triggered anaphylactic reactions. Kounis syndrome has not been described in patients with no evidence of coronary artery disease (type I Kounis) in a scenario of idiopathic anaphylaxis. We reported a case of a 65-year-old white woman with no evidence of coronary artery disease who experienced two myocardial infarctions on separate occasions attributable to idiopathic anaphylaxis...
June 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/28465562/activation-of-the-ileal-neuroendocrine-tumor-cell-line-p-sts-by-acetylcholine-is-amplified-by-histamine-role-of-h3r-and-h4r
#3
Beatrix Pfanzagl, Diana Mechtcheriakova, Anastasia Meshcheryakova, Stephan W Aberle, Roswitha Pfragner, Erika Jensen-Jarolim
Neuroendocrine tumors may present with pseudoallergic reactions like diarrhea and idiopathic anaphylaxis. Here we present the P-STS human ileal neuroendocrine cell line as a model cell line for these tumors. Neuroendocrine markers and changes in cytoplasmic calcium concentration ([Ca(2+)]i) in response to several possible activators of 5-hydroxytryptamine (5-HT) release were analyzed. P-STS cells still expressed chromogranin A and synaptophysin after 2 years of culture. Tryptophan hydroxylase 1 mRNA and a low amount of 5-HT were also detected...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28390586/an-analysis-of-anaphylaxis-cases-at-a-single-pediatric-emergency-department-during-a-1-year-period
#4
Christopher D Wright, Mindy Longjohn, Phillip L Lieberman, Jay Adam Lieberman
BACKGROUND: Case series of anaphylaxis can vary regarding causes, treatments, and follow-up of patients. Unfortunately, case series that are specific to the pediatric population are few. OBJECTIVE: To describe confirmed cases of pediatric anaphylaxis in patients presenting to a pediatric hospital emergency department (ED). METHODS: We identified all ED visits with the International Classification of Diseases, Ninth Revision (ICD-9) codes 995...
April 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28255467/type-1-kounis-syndrome-in-patient-with-idiopathic-anaphylaxis
#5
Tajda Keber, Jana Makuc, Gregor Sekavčnik
Kounis syndrome represents the concurrence of acute coronary syndromes or anginal pain with allergic, hypersensitivity, and anaphylactic reactions. It can be associated with normal coronary angiogram or preexistent coronary pathology. Idiopathic anaphylaxis is defined as anaphylaxis without any identifiable precipitating agent or event. We present a case of male who experienced attacks of dyspnoea, hypoxemia, hypotension, purple-red skin, and chest pain over several years. He was diagnosed with idiopathic anaphylaxis...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28012935/idiopathic-systemic-capillary-leak-syndrome-clarkson-disease
#6
Kirk M Druey, Samir M Parikh
In 1960, Dr Bayard Clarkson described a woman experiencing sporadic recurrent episodes of shock and anasarca. Plasma from an acute attack induced a shock-like syndrome when injected into rats. The enigmatic systemic capillary leak syndrome (SCLS) named for Dr Clarkson is characterized by transient and severe but reversible hemoconcentration and hypoalbuminemia caused by leakage of fluids and macromolecules into tissues. Although less than 500 cases of SCLS have been reported in the literature since 1960, the condition is probably underdiagnosed because of a lack of awareness and a high mortality without treatment...
December 22, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28007089/epidemiology-of-anaphylaxis-at-a-tertiary-care-center-a-report-of-730-cases
#7
Alexei Gonzalez-Estrada, Stacy K Silvers, Asaf Klein, Katrina Zell, Xiao-Feng Wang, David M Lang
BACKGROUND: Recent data reveal that the rate of anaphylaxis is increasing and suggest that idiopathic anaphylaxis may account for most of these cases. OBJECTIVE: To determine the pattern of anaphylaxis at a tertiary care referral center. METHODS: A retrospective electronic medical record review spanning 12 years (2002-2013) identified patients with anaphylaxis. RESULTS: Of the 4,777 records reviewed, 730 patients met our anaphylaxis definition...
January 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27886904/mastocytosis-and-anaphylaxis
#8
REVIEW
Anna Schuch, Knut Brockow
This article updates current knowledge on epidemiology, risk factors, triggers, and management of anaphylaxis in patients with mastocytosis. Hyperactive mast cells and higher number of effector mast cells are speculated to facilitate anaphylaxis in this condition. In children, increased risk is limited to those with extensive skin involvement and high tryptase. In adults, manifestations of anaphylaxis are severe with high frequency of cardiovascular symptoms. Hymenoptera stings are the most common triggers for these reactions; however, idiopathic anaphylaxis and reactions to food or drugs occur...
February 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/27582405/a-multicenter-retrospective-case-study-of-anaphylaxis-triggers-by-age-in-korean-children
#9
So Yeon Lee, Kangmo Ahn, Jihyun Kim, Gwang Cheon Jang, Taek Ki Min, Hyeon Jong Yang, Bok Yang Pyun, Ji Won Kwon, Myung Hyun Sohn, Kyung Won Kim, Kyu Earn Kim, Jinho Yu, Soo Jong Hong, Jung Hyun Kwon, Sung Won Kim, Tae Won Song, Woo Kyung Kim, Hyung Young Kim, You Hoon Jeon, Yong Ju Lee, Hae Ran Lee, Hye Young Kim, Youngmin Ahn, Hye Yung Yum, Dong In Suh, Hyun Hee Kim, Jin Tack Kim, Jeong Hee Kim, Yong Mean Park, Sooyoung Lee
PURPOSE: Although anaphylaxis is recognized as an important, life-threatening condition, data are limited regarding its triggers in different age groups. We aimed to identify anaphylaxis triggers by age in Korean children. METHODS: We performed a retrospective review of medical records for children diagnosed with anaphylaxis between 2009 and 2013 in 23 secondary or tertiary hospitals in South Korea. RESULTS: A total of 991 cases (mean age=5...
November 2016: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27299829/-bone-involvement-in-systemic-mastocytosis-report-of-two-cases
#10
Pablo Florenzano, Verónica Mezzano, Marcela Le-Bert, Gilberto González
Systemic mastocytosis (SM) is characterized by pathologic expansion and activation of mast cells. The main clinical manifestations of SM include skin involvement, gastrointestinal symptoms and anaphylaxis due to the release of its mediators. Thirty percent of pat ients with SM have a low bone mass and 20% fractures. At the same time, SM affects 10% of male patients with idiopathic osteoporosis. Measuring serum tryptase is essential for the screening of MS. We report two cases of SM with bone involvement. A 25-year- old woman with prior diagnosis of SM, based on skin involvement, flushing, high serum tryptase and compatible bone marrow (BM) biopsy and genetic study...
March 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27277133/diagnoses-and-management-of-drug-hypersensitivity-and-anaphylaxis-in-cancer-and-chronic-inflammatory-diseases-reactions-to-taxanes-and-monoclonal-antibodies
#11
Rafael Bonamichi-Santos, Mariana Castells
Due to the increase in utilization of chemotherapies and antibodies, drug hypersensitivity reactions have increased dramatically worldwide, preventing the use of first-line therapies and impacting patients' survival and quality of life. Some of the more frequently used medications in cancer include taxanes for ovarian, lung, breast, and prostate cancers. Monoclonal antibodies are used in the treatment of neoplastic, autoimmune, and inflammatory diseases, and their clinical applications are becoming broader...
June 8, 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27126729/characteristics-of-anaphylaxis-in-907-chinese-patients-referred-to-a-tertiary-allergy-center-a-retrospective-study-of-1-952-episodes
#12
Nannan Jiang, Jia Yin, Liping Wen, Hong Li
PURPOSE: Comprehensive evaluation of anaphylaxis in China is currently lacking. In this study, we characterized the clinical profiles, anaphylactic triggers, and emergency treatment in pediatric and adult patients. METHODS: Outpatients diagnosed with "anaphylaxis" or "severe allergic reactions" in the Department of Allergy, Peking Union Medical College Hospital from January 1, 2000 to June 30, 2014 were analyzed retrospectively. RESULTS: A total of 1,952 episodes of anaphylaxis in 907 patients were analyzed (78% were adults and 22% were children)...
July 2016: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27090058/treating-ige-mediated-diseases-via-targeting-ige-expressing-b-cells-using-an-anti-c%C3%AE%C2%B5mx-antibody
#13
REVIEW
Sean S Liour, Andrew Tom, Yueh-Hsuan Chan, Tse Wen Chang
Targeting the IgE pathway is a clinically validated strategy for treating IgE-mediated diseases. Omalizumab, an anti-IgE antibody, which binds to free IgE and prevents the binding of IgE to FcεRI on mast cells and basophils has been approved for severe persistent allergic asthma and chronic spontaneous (idiopathic) urticaria. The therapeutic efficacy of anti-IgE has also been reported in allergic rhinitis, allergic bronchopulmonary aspergillosis, latex allergy, atopic dermatitis, allergic urticaria, anaphylaxis, and others...
August 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27059930/the-clinical-spectrum-of-omega-5-gliadin-allergy
#14
T A Le, M Al Kindi, J-A Tan, A Smith, R J Heddle, F E Kette, P Hissaria, W B Smith
BACKGROUND: IgE-mediated allergy to the wheat protein omega-5-gliadin (O5G) is associated with wheat-dependent exercise-induced anaphylaxis (WDEIA), where exercise acts as a cofactor, triggering anaphylaxis after wheat ingestion. The wider application of O5G-specific IgE (sIgE) testing has revealed that the manifestations of O5G allergy extend beyond WDEIA. AIMS: This study documents clinical manifestations in a large series of patients with sIgE to O5G. METHODS: A retrospective clinical audit was performed on adult patients with a positive O5G sIgE (>0...
June 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27014771/angiotensin-converting-enzyme-inhibitors-as-a-cause-of-isolated-angioedema-in-a-slovenian-population
#15
Cita Zupanc, Mitja Košnik
INTRODUCTION: Angioedema (AE) is a localized swelling of the subcutaneous tissue and mucosa. We aimed to identify how often AE is associated with angiotensin-converting enzyme inhibitor (ACEI-AE) therapy and whether the severity of AE episodes in these patients differs from the severity in idiopathic AE (IAE). METHODS: We included patients with AE that were referred to a tertiary allergy clinic from 2005 to 2014. We obtained data on AE location, severity, number, and treatment of episodes from patient medical files...
2016: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/26689620/effect-of-use-of-inhaled-epinephrine-on-intramuscular-epinephrine-use-in-patients-with-idiopathic-anaphylaxis-and-angioedema
#16
LETTER
Cosby A Stone, Jane J Choi
No abstract text is available yet for this article.
February 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/26666477/delayed-anaphylaxis-to-alpha-gal-an-oligosaccharide-in-mammalian-meat
#17
REVIEW
Scott P Commins, Maya R Jerath, Kelly Cox, Loren D Erickson, Thomas Platts-Mills
IgE-mediated hypersensitivity refers to immune reactions that can be rapidly progressing and, in the case of anaphylaxis, are occasionally fatal. To that end, identification of the associated allergen is important for facilitating both education and allergen avoidance that are essential to long-term risk reduction. As the number of known exposures associated with anaphylaxis is limited, discovery of novel causative agents is crucial to evaluation and management of patients with idiopathic anaphylaxis. Within the last 10 years several apparently separate observations were recognized to be related, all of which resulted from the development of antibodies to a carbohydrate moiety on proteins...
January 2016: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/26340860/evaluation-of-ige-antibodies-to-omalizumab-xolair%C3%A2-and-their-potential-correlation-to-anaphylaxis
#18
Dana L Baker, Gerald R Nakamura, Henry B Lowman, Saloumeh Kadkhodayan Fischer
Omalizumab (Xolair®) is a recombinant humanized monoclonal antibody that selectively binds to human immunoglobulin E (IgE). Omalizumab is used to treat IgE-mediated diseases such as chronic idiopathic urticaria (CIU) and moderate to severe allergic asthma. In pre-marketing clinical trials in patients with asthma, anaphylaxis was reported in 3 of 3,507 (0.1%) patients. In post-marketing spontaneous reports, the frequency of anaphylaxis attributed to omalizumab use was estimated to be at least 0.2% of patients based on an estimated exposure of about 57,300 patients from June 2003 through December 2006...
January 2016: AAPS Journal
https://www.readbyqxmd.com/read/26310052/anaphylaxis-to-intravenous-methylprednisolone-hemisuccinate-in-a-patient-with-immune-thrombocytopenia
#19
F Alvarez Caro, V García González, J González García, R García Mozo, B García Norniella, A Gómez Farpó
No abstract text is available yet for this article.
2015: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/26261920/intraoperative-cardiopulmonary-arrest-in-children-undergoing-spinal-deformity-correction-causes-and-associated-factors
#20
Emmanuel N Menga, Cole Hirschfeld, Amit Jain, Dong-Phuong Tran, Heather D Caine, Dolores B Njoku, Lori A Karol, Paul D Sponseller
STUDY DESIGN: Retrospective review. OBJECTIVE: To report the incidence of and risk factors for intraoperative cardiopulmonary arrest (ICA) in children undergoing spinal deformity surgery. SUMMARY OF BACKGROUND DATA: Spinal deformities in children are associated with comorbidities that can pose substantial risks during surgery. METHODS: We reviewed records of patients who underwent surgery at two pediatric tertiary-care hospitals from 2004 through 2014...
November 2015: Spine
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