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https://www.readbyqxmd.com/read/29719334/knowledge-and-attitude-about-sexually-transmitted-diseases-among-youth-in-saudi-arabia
#1
Hossam S El-Tholoth, Fahad D Alqahtani, Abdullah A Aljabri, Khalid H Alfaryan, Fares Alharbi, Albaraa A Alhowaimil, Ali Alkharji, Abdulrahman Alrwaily, Ali Obied, Tala Al-Afraa
Background: Sexually transmitted diseases (STDs) are one of the most serious diseases in the world. Our aim was to explore the knowledge and attitude about STDs among the youth. Patients and Methods: This cross-sectional survey was conducted from August 1 to August 13, 2016. Male and female youth between 18 and 25 years were invited to participate in the survey using social media open to all Internet users consisting of questions and statements about STDs, and then the data were analyzed...
April 2018: Urology Annals
https://www.readbyqxmd.com/read/29698714/ph-responsive-delivery-of-griffithsin-from-electrospun-fibers
#2
Kevin M Tyo, Jinghua Duan, Pravallika Kollipara, Mark Vincent C Dela Cerna, Donghan Lee, Kenneth E Palmer, Jill M Steinbach-Rankins
Human immunodeficiency virus (HIV-1) affects over 36 million people globally. Current prevention strategies utilize antiretrovirals that have demonstrated protection, but result in antiviral resistance, adverse toxicity, and require frequent administration. A novel biologic, griffithsin (GRFT), has demonstrated outstanding safety and efficacy against laboratory and primary HIV isolates and against intravaginal murine herpes simplex virus 2 (HSV-2) challenge, making it a promising microbicide candidate. However, transient activity and instability remain concerns surrounding biologic delivery, particularly in the harsh environment of the female reproductive tract (FRT)...
April 23, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29677136/cytoplasmic-translocation-of-nucleolar-protein-nop53-promotes-viral-replication-by-suppressing-host-defense
#3
Wen Meng, Shi-Chong Han, Cui-Cui Li, Hui-Jun Dong, Jian-Yu Chang, Hwa-Chain Robert Wang, Xiao-Jia Wang
NOP53 is a tumor suppressor protein located in the nucleolus and is translocated to the cytoplasm during infection by vesicular stomatitis virus (VSV) and herpes simplex virus type 1 (HSV-1), as shown in our previous study. Cytoplasmic NOP53 interacts with the retinoic acid-inducible gene I (RIG-I) to remove its K63-linked ubiquitination, leading to attenuation of type I interferon IFN-β. In the present study, we found no obvious translocation of NOP53 in infection by a mutant virus lacking ICP4 (HSV-1/d120, replication inadequate)...
April 20, 2018: Viruses
https://www.readbyqxmd.com/read/29619436/concomitant-sexually-transmitted-diseases-in-patients-with-diagnosed-hiv-aids-a-retrospective-study
#4
Densy Violina Harnanti, Afif Nurul Hidayati, Muhammad Miftahussurur
Background: Human immunodeficiency virus (HIV) is a virus that causes Acquired Immunodeficiency Syndrome (AIDS) which weaken the human immune system and thus increasing the incidence of sexually transmitted infections (STIs) and vice versa. Materials and Methods: A retrospective study of STIs in HIV/AIDS patients in Unit Perawatan Intermediate Penyakit Infeksi (UPIPI) Dr. Soetomo General Hospital Surabaya was conducted from January 1st, 2013 to December 31st, 2014...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29594092/herpes-zoster-in-persons-living-with-hiv-1-infection-viremia-and-immunological-defects-are-strong-risk-factors-in-the-era-of-combination-antiretroviral-therapy
#5
Nathaniel B Erdmann, Heather A Prentice, Anju Bansal, Howard W Wiener, Greer Burkholder, Sadeep Shrestha, Jianming Tang
In a cohort of 4,225 persons living with human immunodeficiency virus type 1 (HIV-1) infection (PLWH) enrolled at a southeastern US clinic, the overall rate of incident herpes zoster (HZ) was 101 per 10,000 person-years (PY) between January 1999 and 2017, which nearly quadruples the rate reported for the general US population. In the same cohort, the median age of HZ diagnosis was 39.5 years [interquartile range (IQR) 31.5-49.2] in African American (AA) and 39.1 years (IQR 34.9-45.2) in European American (EA) PLWH, with the highest incidence seen in PLWH who were over 50 years old (144 and 93 per 10,000 PY in AA and EA, respectively, P  = 0...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29592895/kinetic-modeling-of-virus-growth-in-cells
#6
REVIEW
John Yin, Jacob Redovich
When a virus infects a host cell, it hijacks the biosynthetic capacity of the cell to produce virus progeny, a process that may take less than an hour or more than a week. The overall time required for a virus to reproduce depends collectively on the rates of multiple steps in the infection process, including initial binding of the virus particle to the surface of the cell, virus internalization and release of the viral genome within the cell, decoding of the genome to make viral proteins, replication of the genome, assembly of progeny virus particles, and release of these particles into the extracellular environment...
June 2018: Microbiology and Molecular Biology Reviews: MMBR
https://www.readbyqxmd.com/read/29563288/age-associated-differences-in-infection-of-human-skin-in-the-scid-mouse-model-of-varicella-zoster-virus-pathogenesis
#7
Leigh Zerboni, Phillip Sung, Gordon Lee, Ann Arvin
Varicella-zoster virus (VZV) is the skin-tropic human alphaherpesvirus responsible for both varicella and herpes zoster. Varicella and herpes zoster skin lesions have similar morphology but herpes zoster occurs disproportionally in older individuals and is often associated with a more extensive local rash and severe zoster-related neuralgia. We hypothesized that skin aging could also influence the outcome of the anterograde axonal transport of VZV to skin. We utilized human skin xenografts maintained in immunodeficient (SCID) mice to study VZV-induced skin pathology in vivo in fetal and adult skin xenografts...
March 21, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29529337/copper-supplementation-in-premature-infants-with-parenteral-nutrition-associated-cholestasis
#8
Kunal Gupta, Hongyue Wang, Sanjiv B Amin
The aim of this study was to evaluate the effect of intermittent parenteral copper supplementation (IPC) on serum copper status and biochemical and hematological measures of copper toxicity and deficiency in premature infants with parenteral nutrition (PN)-associated cholestasis (PNAC). We performed a prospective nested observational study in premature infants with PNAC who received IPC after the development of PNAC. Infants with chromosomal disorders, TORCH (toxoplasmosis, parvovirus, syphilis, rubella, cytomegalovirus, herpes, human immunodeficiency virus) infection, metabolic disorder, and/or surgical abnormality of the hepatobiliary system were excluded...
March 12, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29522484/antiviral-effects-of-abma-against-herpes-simplex-virus-type-2-in-vitro-and-in-vivo
#9
Wenwen Dai, Yu Wu, Jinpeng Bi, Shuai Wang, Fang Li, Wei Kong, Julien Barbier, Jean-Christophe Cintrat, Feng Gao, Daniel Gillet, Weiheng Su, Chunlai Jiang
Herpes simplex virus type 2 (HSV-2) is the causative pathogen of genital herpes and is closely associated with the occurrence of cervical cancer and human immunodeficiency virus (HIV) infection. The absence of an effective vaccine and the emergence of drug resistance to commonly used nucleoside analogs emphasize the urgent need for alternative antivirals against HSV-2. Recently, ABMA [1-adamantyl (5-bromo-2-methoxybenzyl) amine] has been demonstrated to be an inhibitor of several pathogens exploiting host-vesicle transport, which also participates in the HSV-2 lifecycle...
March 9, 2018: Viruses
https://www.readbyqxmd.com/read/29521099/disruption-of-the-blood-brain-barrier-is-vital-property-of-neurotropic-viral-infection-of-the-central-nervous-system
#10
M M Jamil Al-Obaidi, A Bahadoran, S M Wang, R Manikam, Ch S Raju, S D Sekaran
The blood brain barrier consisting of astrocytes, pericytes and brain microvascular endothelial cells plays a vital role in the pathogenesis of neurotropic viruses by controlling the access of circulating molecules, immune cells or viruses into the central nervous system (CNS). However, this barrier is not impenetrable and neuroviruses have evolved to disrupt and evade it. This review aims to describe the underlying entry mechanisms of several neuroviruses such as (Japanese encephalitis virus (JEV), West Nile virus (WNV), Zika virus (ZIKV), Nipah virus (NiV), Rabies virus (RABV), Herpes simplex virus (HSV) and Human immunodeficiency virus (HIV)) into the CNS through BBB disruption...
2018: Acta Virologica
https://www.readbyqxmd.com/read/29516667/effusion-based-lymphoma-with-morphological-regression-but-with-clonal-genetic-features-after-aspiration
#11
Meng-Chen Tsai, Chun-Chi Kuo, Ying-Zhen Su, Yen-Chuan Hsieh, Shih-Sung Chuang
Effusion-based lymphoma (EBL) is a rare but distinct entity of large B-cell lymphoma in effusion without association with human herpes virus-8 (HHV-8). Spontaneous regression after pleurocentesis has been observed; but to our knowledge, there are no reports on the morphological and molecular features of subsequent aspirations in regressing cases. Here, we report the case of a 92-year-old male with chronic obstructive pulmonary disease, who presented with right pleural effusion. He had no human immunodeficiency virus, hepatitis B virus, or hepatitis C virus infection, and CT scans revealed no mass lesion...
March 8, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29511591/scrotal-kaposi-s-sarcoma-in-hiv-negative-patient-a-case-report-and-review-of-the-literature
#12
Mustafa Gürkan Yenice, Esra Varnalı, Kamil Gökhan Şeker, Ayşe Kavak, Volkan Tuğcu
Kaposi's Sarcoma (KS) is a malignancy that generally effects the skin, and can be systemic with internal organ involvement. It originates from the vascular endothelium. KS's relationship with human immunodeficiency virus (HIV) infection is well known. Isolated scrotal KS in the urogenital system is quite rare and scrotal KS in an HIV-negative patient is limited to a few cases. In this case report, the biopsy result from the violescent nodular lesions on the scrotum of the HIV-negative 81-year-old patient was found compatible with KS and a pathology was not detected in the systemic screening...
March 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29468223/a-case-of-hypertrophic-herpes-simplex-virus-affecting-the-eyelid-and-cornea-masquerading-as-igg4-related-disease
#13
Prachi Dua, Roman Shinder, Derek B Laskar, Douglas R Lazzaro, Allison E Rizzuti
Purpose: To report a case of hypertrophic herpes simplex virus (HSV) of the eyelid and cornea masquerading as IgG4-related disease. Observations: A 37-year old African American female with a past medical history of human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) and a recent history of treated genital herpes, presented with an ulcerative lesion of the left upper and lower eyelids, and severe ocular inflammation with symblepharon...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29454196/sexually-transmitted-infections-and-immune-activation-among-hiv-infected-but-virally-suppressed-youth-on-antiretroviral-therapy
#14
Tanya L Kowalczyk Mullins, Su X Li, James Bethel, Maureen M Goodenow, Stephanie Hudey, John W Sleasman
BACKGROUND: Human immunodeficiency virus (HIV) infection is associated with chronic immune activation, and concurrent sexually transmitted infections (STIs) may increase immune activation. OBJECTIVES: Because HIV-infected youth are at high risk of STIs and little is known about the impact of STIs on immune activation in HIV-infected youth, we conducted an exploratory study examining the association between STIs and systemic inflammation and immune activation among HIV-infected adolescents...
May 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29449725/iatrogenic-colorectal-kaposi-s-sarcoma-complicating-a-refractory-ulcerative-colitis-in-a-human-immunodeficiency-negative-virus-patient
#15
L Chtourou, L Ayedi, H Rejab, M Boudabous, L Mnif, A Grati, T Boudaouara, R Mzali, A Amouri, N Tahri
Kaposi sarcoma is an unusual tumor associated to a human herpes virus-8 infection involving the skin or internal organs. Iatrogenic Kaposi's sarcoma often occurs in patients receiving immunosuppressive therapy. So far, a few Kaposi's sarcoma cases have been reported in the literature associated with inflammatory bowel diseases. We report a 53-year-old male diagnosed with a severe refractory ulcerative colitis who was treated with corticosteroids and azathioprine. The patient underwent a colectomy after the failure of medical treatment...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29405375/herpes-zoster-at-the-vaccination-site-in-immunized-healthy-children
#16
Hannah Song, Keith W Morley, Ryan M Trowbridge, Daniel C Butler, Marilyn G Liang, Stephen E Gellis, Jennifer T Huang
In this case series, we report seven immunized healthy children without underlying immunodeficiency who presented with herpes zoster that correlated with varicella-zoster vaccination site. The morphology of the lesions included erythematous papules, pseudovesicles, and plaques, with associated pain in two and pruritus in three patients; systemic symptoms ranged from none to low-grade fevers, upper respiratory symptoms, and joint pain. These cases highlight the clinical, diagnostic, and therapeutic implications of herpes zoster in vaccinated children...
March 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29399578/anti-infective-potential-of-catechins-and-their-derivatives-against-viral-hepatitis
#17
REVIEW
Jae-Min Song
Polyphenols including catechins from green tea ( Camellia sinensis ) have been reported to have anti-infective activities against a broad spectrum of viruses and other pathogens. During the last two decades, antiviral activities of catechins with different modes of action have been demonstrated on diverse families of viruses, such as human immunodeficiency virus, Herpes simplex virus, influenza virus, hepatitis B and C virus. In this study, we focused on the antiviral properties of catechins and their derivatives against viral hepatitis which have become a key public health issue due to their serious impact on human health with liver diseases...
January 2018: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/29379004/pneumomediastinum-and-pneumothorax-associated-with-herpes-simplex-virus-hsv-pneumonia
#18
Fermín López-Rivera, Xavier Colón Rivera, Hernán A González Monroig, Juan Garcia Puebla
BACKGROUND Pneumonia is one of the most common causes of death from infectious disease in the United States (US). Although most cases of community-acquired pneumonia (CAP) are secondary to bacterial infection, up to one-third of cases are secondary to viral infection, most commonly due to rhinovirus and influenza virus. Pneumonia due to herpes simplex virus (HSV) is rare, and there is limited knowledge of the pathogenesis and clinical complications. This report is of a fatal case of HSV pneumonia associated with bilateral pneumothorax and pneumomediastinum...
January 30, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29357582/image-gallery-lenalidomide-for-the-treatment-of-pseudotumoral-herpes-simplex-virus-type-2-infection-in-human-immunodeficiency-virus-infection
#19
J Gottlieb, M Janier, M Battistella, H Bachelez
No abstract text is available yet for this article.
January 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29356205/antiviral-potential-of-medicinal-plants-against-hiv-hsv-influenza-hepatitis-and-coxsackievirus-a-systematic-review
#20
REVIEW
Muhammad Akram, Imtiaz Mahmood Tahir, Syed Muhammad Ali Shah, Zahed Mahmood, Awais Altaf, Khalil Ahmad, Naveed Munir, Muhammad Daniyal, Suhaila Nasir, Huma Mehboob
Viral infections are being managed therapeutically through available antiviral regimens with unsatisfactory clinical outcomes. The refractory viral infections resistant to available antiviral drugs are alarming threats and a serious health concern. For viral hepatitis, the interferon and vaccine therapies solely are not ultimate solutions due to recurrence of hepatitis C virus. Owing to the growing incidences of viral infections and especially of resistant viral strains, the available therapeutic modalities need to be improved, complemented with the discovery of novel antiviral agents to combat refractory viral infections...
January 22, 2018: Phytotherapy Research: PTR
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