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JOURNAL ARTICLE
Andrew B Lassman, Stephanie L Pugh, Tony J C Wang, Kenneth Aldape, Hui K Gan, Matthias Preusser, Michael A Vogelbaum, Erik P Sulman, Minhee Won, Peixin Zhang, Golnaz Moazami, Marian S Macsai, Mark R Gilbert, Earle E Bain, Vincent Blot, Peter J Ansell, Suvajit Samanta, Madan G Kundu, Terri S Armstrong, Jeffrey S Wefel, Clemens Seidel, Filip Y de Vos, Sigmund Hsu, Andrés F Cardona, Giuseppe Lombardi, Dmitry Bentsion, Richard A Peterson, Craig Gedye, Véronique Bourg, Antje Wick, Walter J Curran, Minesh P Mehta
BACKGROUND: Approximately 50% of newly diagnosed glioblastomas (GBMs) harbor EGFR gene amplification (EGFR-amp). Preclinical and early phase clinical data suggested efficacy of depatuxizumab mafodotin (depatux-m), an antibody drug conjugate (ADC) comprised of a monoclonal antibody that binds activated EGFR (overexpressed wild-type and EGFRvIII-mutant) linked to a microtubule-inhibitor toxin in EGFR-amp GBMs. METHODS: In this phase III trial, adults with centrally confirmed, EGFR-amp, newly diagnosed GBM were randomized 1:1 to radiotherapy, temozolomide, and depatux-m/placebo...
July 15, 2022: Neuro-oncology
#22
JOURNAL ARTICLE
Andrea M Plawecki, Abdulmalik Saleem, Dace Zvirbulis, Edward L Peterson, Frederick Yoo, Ashhar Ali, John R Craig
OBJECTIVES: Investigate the use of nasal endoscopy, sinus imaging, and neurologic evaluation in patients presenting to a rhinologist primarily for craniofacial pain. METHODS: This was a retrospective analysis of consecutive outpatients presenting to a rhinologist between 2016 and 2019 with chief complaints of craniofacial pain with or without other sinonasal symptoms, who were then referred to and evaluated by headache specialists. Data analyzed included sinusitis symptoms, Sino-Nasal Outcome Test (SNOT-22) scores (and facial pain subscores), pain location, nasal endoscopy, computed tomography (CT) findings, and headache diagnoses made by headache specialists...
July 6, 2022: Annals of Otology, Rhinology, and Laryngology
#23
JOURNAL ARTICLE
Christine S Hopp, Jeff Skinner, Sarah L Anzick, Christopher M Tipton, Mary E Peterson, Shanping Li, Safiatou Doumbo, Kassoum Kayentao, Aissata Ongoiba, Craig Martens, Boubacar Traore, Peter D Crompton
Several infectious and autoimmune diseases are associated with an expansion of CD21- CD27- atypical B cells (atBCs) that up-regulate inhibitory receptors and exhibit altered B cell receptor (BCR) signaling. The function of atBCs remains unclear, and few studies have investigated the biology of pathogen-specific atBCs during acute infection. Here, we performed longitudinal flow cytometry analyses and RNA sequencing of Plasmodium falciparum ( Pf )-specific B cells isolated from study participants before and shortly after febrile malaria, with simultaneous analysis of influenza hemagglutinin (HA)-specific B cells as a comparator...
May 13, 2022: Science Immunology
#24
JOURNAL ARTICLE
Eshim S Jami, Anke R Hammerschlag, Hill F Ip, Andrea G Allegrini, Beben Benyamin, Richard Border, Elizabeth W Diemer, Chang Jiang, Ville Karhunen, Yi Lu, Qing Lu, Travis T Mallard, Pashupati P Mishra, Ilja M Nolte, Teemu Palviainen, Roseann E Peterson, Hannah M Sallis, Andrey A Shabalin, Ashley E Tate, Elisabeth Thiering, Natàlia Vilor-Tejedor, Carol Wang, Ang Zhou, Daniel E Adkins, Silvia Alemany, Helga Ask, Qi Chen, Robin P Corley, Erik A Ehli, Luke M Evans, Alexandra Havdahl, Fiona A Hagenbeek, Christian Hakulinen, Anjali K Henders, Jouke Jan Hottenga, Tellervo Korhonen, Abdullah Mamun, Shelby Marrington, Alexander Neumann, Kaili Rimfeld, Fernando Rivadeneira, Judy L Silberg, Catharina E van Beijsterveldt, Eero Vuoksimaa, Alyce M Whipp, Tong Xiaoran, Ole A Andreassen, Dorret I Boomsma, Sandra A Brown, S Alexandra Burt, William Copeland, Danielle M Dick, K Paige Harden, Kathleen Mullan Harris, Catharina A Hartman, Joachim Heinrich, John K Hewitt, Christian Hopfer, Elina Hypponen, Marjo-Riitta Jarvelin, Jaakko Kaprio, Liisa Keltikangas-Järvinen, Kelly L Klump, Kenneth Krauter, Ralf Kuja-Halkola, Henrik Larsson, Terho Lehtimäki, Paul Lichtenstein, Sebastian Lundström, Hermine H Maes, Per Magnus, Marcus R Munafò, Jake M Najman, Pål R Njølstad, Albertine J Oldehinkel, Craig E Pennell, Robert Plomin, Ted Reichborn-Kjennerud, Chandra Reynolds, Richard J Rose, Andrew Smolen, Harold Snieder, Michael Stallings, Marie Standl, Jordi Sunyer, Henning Tiemeier, Sally J Wadsworth, Tamara L Wall, Andrew J O Whitehouse, Gail M Williams, Eivind Ystrøm, Michel G Nivard, Meike Bartels, Christel M Middeldorp
OBJECTIVE: To investigate the genetic architecture of internalizing symptoms in childhood and adolescence. METHOD: In 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptoms, in a total of 64,561 children aged between 3 and 18. Results were aggregated in meta-analyses that accounted for sample overlap, first using all available data, and then using subsets of measurements grouped by rater, age and instrument...
March 30, 2022: Journal of the American Academy of Child and Adolescent Psychiatry
#25
JOURNAL ARTICLE
J Ignacio Gutierrez, Gregory P Brittingham, Yonca B Karadeniz, Kathleen D Tran, Arnob Dutta, Alex S Holehouse, Craig L Peterson, Liam J Holt
It is increasingly appreciated that intracellular pH changes are important biological signals. This motivates the elucidation of molecular mechanisms of pH-sensing. We determined that a nucleocytoplasmic pH oscillation was required for the transcriptional response to carbon starvation in Saccharomyces cerevisiae . The SWI/SNF chromatin remodeling complex is a key mediator of this transcriptional response. A glutamine-rich low complexity domain (QLC) in the SNF5 subunit of this complex, and histidines within this sequence, were required for efficient transcriptional reprogramming...
February 7, 2022: ELife
#26
JOURNAL ARTICLE
Alysia R Bryll, Craig L Peterson
Eukaryotic cells maintain an optimal level of mRNAs through unknown mechanisms that balance RNA synthesis and degradation. We found that inactivation of the RNA exosome leads to global reduction of nascent mRNA transcripts, and that this defect is accentuated by loss of deposition of histone variant H2A.Z. We identify the mRNA for the sirtuin deacetylase Hst3 as a key target for the RNA exosome that mediates communication between RNA degradation and transcription machineries. These findings reveal how the RNA exosome and H2A...
December 16, 2021: Genes & Development
#27
JOURNAL ARTICLE
Jennifer E Klomp, Ye S Lee, Craig M Goodwin, Björn Papke, Jeff A Klomp, Andrew M Waters, Clint A Stalnecker, Jonathan M DeLiberty, Kristina Drizyte-Miller, Runying Yang, J Nathaniel Diehl, Hongwei H Yin, Mariaelena Pierobon, Elisa Baldelli, Meagan B Ryan, Siqi Li, Jackson Peterson, Amber R Smith, James T Neal, Aaron K McCormick, Calvin J Kuo, Christopher M Counter, Emanuel F Petricoin, Adrienne D Cox, Kirsten L Bryant, Channing J Der
We apply genetic screens to delineate modulators of KRAS mutant pancreatic ductal adenocarcinoma (PDAC) sensitivity to ERK inhibitor treatment, and we identify components of the ATR-CHK1 DNA damage repair (DDR) pathway. Pharmacologic inhibition of CHK1 alone causes apoptotic growth suppression of both PDAC cell lines and organoids, which correlates with loss of MYC expression. CHK1 inhibition also activates ERK and AMPK and increases autophagy, providing a mechanistic basis for increased efficacy of concurrent CHK1 and ERK inhibition and/or autophagy inhibition with chloroquine...
November 30, 2021: Cell Reports
#28
JOURNAL ARTICLE
Jonathan E Butner, Craig J Bryan, Jeffrey V Tabares, Lily A Brown, Stacey Young-McCaughan, Willie J Hale, Jim Mintz, Brett T Litz, Jeffrey S Yarvis, Brooke A Fina, Edna B Foa, Patricia A Resick, Alan L Peterson
OBJECTIVE: Failing to account for temporal dynamics can hinder our understanding of suicidal ideation and the potential mechanisms underlying increased risk for suicide death and suicide attempts associated with posttraumatic stress disorder (PTSD). To address these limitations, this study used an analytic approach based on Dynamical Systems Theory to describe temporal patterns associated with multiple dimensions of suicidal ideation in a treatment-seeking sample of military personnel diagnosed with PTSD...
October 2021: Psychological Trauma: Theory, Research, Practice and Policy
#29
JOURNAL ARTICLE
Alan L Peterson, Stacey Young-McCaughan, John D Roache, Jim Mintz, Brett T Litz, Douglas E Williamson, Patricia A Resick, Edna B Foa, Donald D McGeary, Katherine A Dondanville, Daniel J Taylor, Jennifer Schuster Wachen, Peter T Fox, Craig J Bryan, Carmen P McLean, Kristi E Pruiksma, Jeffrey S Yarvis, Barbara L Niles, Chadi G Abdallah, Lynnette A Averill, Sudie E Back, Monty T Baker, Tabatha H Blount, Adam M Borah, Elisa V Borah, Matthew S Brock, Lily A Brown, Matthew M Burg, Jeffrey A Cigrang, Bryann B DeBeer, Ellen R DeVoe, Brooke A Fina, Julianne C Flanagan, Steffany J Fredman, Cubby L Gardner, Robert R Gatchel, Jeffrey L Goodie, Ralitza Gueorguieva, Jay B Higgs, Vanessa M Jacoby, Kevin M Kelly, John H Krystal, M Danet Lapiz-Bluhm, Argelio L López-Roca, Brian P Marx, Douglas M Maurer, Meghan E McDevitt-Murphy, Cindy A McGeary, Eric C Meyer, Shannon R Miles, Candice M Monson, David A Morilak, John C Moring, Vincent Mysliwiec, Karin L Nicholson, Sheila A M Rauch, David S Riggs, Craig S Rosen, M David Rudd, Richard P Schobitz, Christian C Schrader, Antoinette M Shinn, Paulo R Shiroma, Denise M Sloan, Stephen L Stern, Randy Strong, Steven D Vannoy, Keith A Young, Terence M Keane
The STRONG STAR Consortium (South Texas Research Organizational Network Guiding Studies on Trauma and Resilience) and the Consortium to Alleviate PTSD are interdisciplinary and multi-institutional research consortia focused on the detection, diagnosis, prevention, and treatment of combat-related posttraumatic stress disorder (PTSD) and comorbid conditions in military personnel and veterans. This manuscript outlines the consortia's state-of-the-science collaborative research model and how this can be used as a roadmap for future trauma-related research...
September 29, 2021: Contemporary Clinical Trials
#30
RANDOMIZED CONTROLLED TRIAL
Brian P Marx, Brooke A Fina, Denise M Sloan, Stacey Young-McCaughan, Katherine A Dondanville, Hannah C Tyler, Abby E Blankenship, Christian C Schrader, Alexander M Kaplan, Vanessa R Green, Craig J Bryan, Willie J Hale, Jim Mintz, Alan L Peterson
Studies of active duty service members have shown that military personnel who screen positive for posttraumatic stress disorder (PTSD) are more than twice as likely to make a suicide attempt. Evidence-based PTSD treatments can reduce suicidal ideation; however, it can be challenging to provide evidence-based, trauma-focused, PTSD treatment to high-risk patients on an acute psychiatric inpatient unit because the priority of care is stabilization. Treatment for PTSD requires more time and resources than are typically afforded during inpatient hospitalizations...
November 2021: Contemporary Clinical Trials
#31
JOURNAL ARTICLE
Hill F Ip, Camiel M van der Laan, Eva M L Krapohl, Isabell Brikell, Cristina Sánchez-Mora, Ilja M Nolte, Beate St Pourcain, Koen Bolhuis, Teemu Palviainen, Hadi Zafarmand, Lucía Colodro-Conde, Scott Gordon, Tetyana Zayats, Fazil Aliev, Chang Jiang, Carol A Wang, Gretchen Saunders, Ville Karhunen, Anke R Hammerschlag, Daniel E Adkins, Richard Border, Roseann E Peterson, Joseph A Prinz, Elisabeth Thiering, Ilkka Seppälä, Natàlia Vilor-Tejedor, Tarunveer S Ahluwalia, Felix R Day, Jouke-Jan Hottenga, Andrea G Allegrini, Kaili Rimfeld, Qi Chen, Yi Lu, Joanna Martin, María Soler Artigas, Paula Rovira, Rosa Bosch, Gemma Español, Josep Antoni Ramos Quiroga, Alexander Neumann, Judith Ensink, Katrina Grasby, José J Morosoli, Xiaoran Tong, Shelby Marrington, Christel Middeldorp, James G Scott, Anna Vinkhuyzen, Andrey A Shabalin, Robin Corley, Luke M Evans, Karen Sugden, Silvia Alemany, Lærke Sass, Rebecca Vinding, Kate Ruth, Jess Tyrrell, Gareth E Davies, Erik A Ehli, Fiona A Hagenbeek, Eveline De Zeeuw, Toos C E M Van Beijsterveldt, Henrik Larsson, Harold Snieder, Frank C Verhulst, Najaf Amin, Alyce M Whipp, Tellervo Korhonen, Eero Vuoksimaa, Richard J Rose, André G Uitterlinden, Andrew C Heath, Pamela Madden, Jan Haavik, Jennifer R Harris, Øyvind Helgeland, Stefan Johansson, Gun Peggy S Knudsen, Pal Rasmus Njolstad, Qing Lu, Alina Rodriguez, Anjali K Henders, Abdullah Mamun, Jackob M Najman, Sandy Brown, Christian Hopfer, Kenneth Krauter, Chandra Reynolds, Andrew Smolen, Michael Stallings, Sally Wadsworth, Tamara L Wall, Judy L Silberg, Allison Miller, Liisa Keltikangas-Järvinen, Christian Hakulinen, Laura Pulkki-Råback, Alexandra Havdahl, Per Magnus, Olli T Raitakari, John R B Perry, Sabrina Llop, Maria-Jose Lopez-Espinosa, Klaus Bønnelykke, Hans Bisgaard, Jordi Sunyer, Terho Lehtimäki, Louise Arseneault, Marie Standl, Joachim Heinrich, Joseph Boden, John Pearson, L John Horwood, Martin Kennedy, Richie Poulton, Lindon J Eaves, Hermine H Maes, John Hewitt, William E Copeland, Elizabeth J Costello, Gail M Williams, Naomi Wray, Marjo-Riitta Järvelin, Matt McGue, William Iacono, Avshalom Caspi, Terrie E Moffitt, Andrew Whitehouse, Craig E Pennell, Kelly L Klump, S Alexandra Burt, Danielle M Dick, Ted Reichborn-Kjennerud, Nicholas G Martin, Sarah E Medland, Tanja Vrijkotte, Jaakko Kaprio, Henning Tiemeier, George Davey Smith, Catharina A Hartman, Albertine J Oldehinkel, Miquel Casas, Marta Ribasés, Paul Lichtenstein, Sebastian Lundström, Robert Plomin, Meike Bartels, Michel G Nivard, Dorret I Boomsma
Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. We analyzed phenotype assessments for a total of 328 935 observations from 87 485 children aged between 1.5 and 18 years, while accounting for sample overlap. We also meta-analyzed within subsets of the data, i.e., within rater, instrument and age. SNP-heritability for the overall meta-analysis (AGGoverall ) was 3...
July 30, 2021: Translational Psychiatry
#32
JOURNAL ARTICLE
Akash Goyal, Tony Schibler, Brooke Alhanti, Karen L Hannan, Christopher B Granger, Michael A Blazing, Renato D Lopes, John H Alexander, Eric D Peterson, Sunil V Rao, Jennifer B Green, Matthew T Roe, Tyrus Rorick, Lisa G Berdan, Craig Reist, Kenneth W Mahaffey, Robert A Harrington, Robert M Califf, Manesh R Patel, Adrian F Hernandez, W Schuyler Jones
Importance: Randomized clinical trials (RCTs) are critical in advancing patient care, yet conducting such large-scale trials requires tremendous resources and coordination. Clinical site start-up performance metrics can provide insight into opportunities for improved trial efficiency but have not been well described. Objective: To measure the start-up time needed to reach prespecified milestones across sites in large cardiovascular RCTs in North America and to evaluate how these metrics vary by time and type of regulatory review process...
July 1, 2021: JAMA Network Open
#33
JOURNAL ARTICLE
John R Craig, Atif J Cheema, Raven T Dunn, Swapna Vemuri, Edward L Peterson
OBJECTIVE: Odontogenic sinusitis (ODS) can cause infectious orbital, intracranial, and osseous complications. Diagnosis and management of complicated ODS have not been discussed in recent sinusitis guidelines. The purpose of this systematic review was to describe epidemiological and clinical features, as well as management strategies of complicated ODS. DATA SOURCES: PubMed, EMBASE, and Cochrane Library. REVIEW METHODS: A systematic review was performed to describe various features of complicated ODS...
April 2022: Otolaryngology—Head and Neck Surgery
#34
JOURNAL ARTICLE
Elisa Oberbeckmann, Vanessa Niebauer, Shinya Watanabe, Lucas Farnung, Manuela Moldt, Andrea Schmid, Patrick Cramer, Craig L Peterson, Sebastian Eustermann, Karl-Peter Hopfner, Philipp Korber
Arrays of regularly spaced nucleosomes dominate chromatin and are often phased by alignment to reference sites like active promoters. How the distances between nucleosomes (spacing), and between phasing sites and nucleosomes are determined remains unclear, and specifically, how ATP-dependent chromatin remodelers impact these features. Here, we used genome-wide reconstitution to probe how Saccharomyces cerevisiae ATP-dependent remodelers generate phased arrays of regularly spaced nucleosomes. We find that remodelers bear a functional element named the 'ruler' that determines spacing and phasing in a remodeler-specific way...
May 28, 2021: Nature Communications
#35
JOURNAL ARTICLE
Lily A Brown, Craig J Bryan, Jonathan E Butner, Jeffrey V Tabares, Stacey Young-McCaughan, Willie J Hale, Brooke A Fina, Edna B Foa, Patricia A Resick, Daniel J Taylor, Hillary Coon, Douglas E Williamson, Katherine A Dondanville, Elisa V Borah, Carmen P McLean, Jennifer Schuster Wachen, Kristi E Pruiksma, Ann Marie Hernandez, Brett T Litz, Jim Mintz, Jeffrey S Yarvis, Adam M Borah, Karin L Nicholson, Douglas M Maurer, Kevin M Kelly, Alan L Peterson
Objectives: Several recent studies have demonstrated that posttraumatic stress disorder (PTSD) and insomnia treatments are associated with significant reductions in suicidal ideation (SI) among service members. However, few investigations have evaluated the manner in which suicide risk changes over time among military personnel receiving PTSD or insomnia treatments. This paper describes the study protocol for a project with these aims: (1) explore potential genetic, clinical, and demographic subtypes of suicide risk in a large cohort of deployed service members; (2) explore subtype change in SI as a result of evidence-based psychotherapies for PTSD and insomnia; (3) evaluate the speed of change in suicide risk; and (4) identify predictors of higher- and lower-risk for suicide...
March 2021: Contemporary Clinical Trials Communications
#36
JOURNAL ARTICLE
Bryann DeBeer, Sylvia Baack, Kathryn Bongiovanni, Elisa Borah, Craig Bryan, Kattina Bryant, Ruth Cassidy, Stephanie Clafferty, Germaine Franciosi, Jenna Heise, Claire Hoffmire, Robin Keene, Joseph Mignogna, Nathaniel Mohatt, Lindsey L Monteith, Alan Peterson, Dawn Pierson, Edgar Villarreal, Kimberly Weinberg, Marjory Williams, Samantha Synett, Justin Benzer
Background: While the US Department of Veterans Affairs has made significant strides to prevent veteran suicide, efforts have largely targeted veterans actively engaged in and eligible for Veterans Health Administration (VHA) care, which is consistent with the VHA mission. The majority of veterans are not enrolled in VHA care, and many are ineligible for services. Veterans not connected to VHA have experienced an increase in suicides in recent years. Observations: Since 2018, VHA National Center for Patient Safety has funded the Patient Safety Center of Inquiry-Suicide Prevention Collaborative (PSCI-SPC), which has worked to develop, implement, and evaluate practical solutions aimed at curbing the rising suicide rate among veterans not receiving VHA care...
November 2020: Federal Practitioner
#37
JOURNAL ARTICLE
Dharam J Kumbhani, Christopher P Cannon, Craig J Beavers, Deepak L Bhatt, Adam Cuker, Ty J Gluckman, Joseph E Marine, Roxana Mehran, Steven R Messe, Nimesh S Patel, Benjamin E Peterson, Kenneth Rosenfield, Sarah A Spinler, Vinod H Thourani
No abstract text is available yet for this article.
February 9, 2021: Journal of the American College of Cardiology
#38
RANDOMIZED CONTROLLED TRIAL
Benjamin E Peterson, Deepak L Bhatt, Ph Gabriel Steg, Michael Miller, Eliot A Brinton, Terry A Jacobson, Steven B Ketchum, Rebecca A Juliano, Lixia Jiao, Ralph T Doyle, Craig Granowitz, C Michael Gibson, Duane Pinto, Robert P Giugliano, Matthew J Budoff, Jean-Claude Tardif, Subodh Verma, Christie M Ballantyne
BACKGROUND: Patients with elevated triglycerides despite statin therapy have increased risk for ischemic events, including coronary revascularizations. METHODS: REDUCE-IT (The Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial), a multicenter, double-blind, placebo-controlled trial, randomly assigned statin-treated patients with elevated triglycerides (135-499 mg/dL), controlled low-density lipoprotein (41-100 mg/dL), and either established cardiovascular disease or diabetes plus other risk factors to receive icosapent ethyl 4 g/d or placebo...
January 5, 2021: Circulation
#39
JOURNAL ARTICLE
Wallace H Liu, Jie Zheng, Jessica L Feldman, Mark A Klein, Vyacheslav I Kuznetsov, Craig L Peterson, Patrick R Griffin, John M Denu
The protein deacetylase SIRT6 maintains cellular homeostasis through multiple pathways that include the deacetylation of histone H3 and repression of transcription. Prior work suggests that SIRT6 is associated with chromatin and can substantially reduce global levels of H3 acetylation, but how SIRT6 is able to accomplish this feat is unknown. Here, we describe an exquisitely tight interaction between SIRT6 and nucleosome core particles, in which a 2:1 enzyme:nucleosome complex assembles via asymmetric binding with distinct affinities...
October 16, 2020: Nature Communications
#40
JOURNAL ARTICLE
Salih Topal, Christopher Van, Yong Xue, Michael F Carey, Craig L Peterson
The proper coordination of transcription with DNA replication and repair is central for genomic stability. We investigate how the INO80C chromatin remodeling enzyme might coordinate these genomic processes. We find that INO80C co-localizes with the origin recognition complex (ORC) at yeast replication origins and is bound to replication initiation sites in mouse embryonic stem cells (mESCs). In yeast, INO80C recruitment requires origin sequences but does not require ORC, suggesting that recruitment is independent of pre-replication complex assembly...
September 8, 2020: Cell Reports
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