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Craig L. Peterson

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https://www.readbyqxmd.com/read/27818141/hsp90-and-p23-molecular-chaperones-control-chromatin-architecture-by-maintaining-the-functional-pool-of-the-rsc-chromatin-remodeler
#1
Frank J Echtenkamp, Zlata Gvozdenov, Nicholas L Adkins, Yang Zhang, Melinda Lynch-Day, Shinya Watanabe, Craig L Peterson, Brian C Freeman
Molecular chaperones govern protein homeostasis, being allied to the beginning (folding) and ending (degradation) of the protein life cycle. Yet, the Hsp90 system primarily associates with native factors, including fully assembled complexes. The significance of these connections is poorly understood. To delineate why Hsp90 and its cochaperone p23 interact with a mature structure, we focused on the RSC chromatin remodeler. Both Hsp90 and p23 triggered the release of RSC from DNA or a nucleosome. Although Hsp90 only freed bound RSC, p23 enhanced nucleosome remodeling prior to discharging the complex...
December 1, 2016: Molecular Cell
https://www.readbyqxmd.com/read/27768892/genomic-nucleosome-organization-reconstituted-with-pure-proteins
#2
Nils Krietenstein, Megha Wal, Shinya Watanabe, Bongsoo Park, Craig L Peterson, B Franklin Pugh, Philipp Korber
Chromatin remodelers regulate genes by organizing nucleosomes around promoters, but their individual contributions are obfuscated by the complex in vivo milieu of factor redundancy and indirect effects. Genome-wide reconstitution of promoter nucleosome organization with purified proteins resolves this problem and is therefore a critical goal. Here, we reconstitute four stages of nucleosome architecture using purified components: yeast genomic DNA, histones, sequence-specific Abf1/Reb1, and remodelers RSC, ISW2, INO80, and ISW1a...
October 20, 2016: Cell
https://www.readbyqxmd.com/read/27578267/rna-polymerase-ii-depletion-promotes-transcription-of-alternative-mrna-species
#3
Lijian Yu, Mayuri Rege, Craig L Peterson, Michael R Volkert
BACKGROUND: Cells respond to numerous internal and external stresses, such as heat, cold, oxidative stress, DNA damage, and osmotic pressure changes. In most cases, the primary response to stress is transcriptional induction of genes that assist the cells in tolerating the stress and facilitate the repair of the cellular damage. However, when the transcription machinery itself is stressed, responding by such standard mechanisms may not be possible. RESULTS: In this study, we demonstrate that depletion or inactivation of RNA polymerase II (RNAPII) changes the preferred polyadenylation site usage for several transcripts, and leads to increased transcription of a specific subset of genes...
2016: BMC Molecular Biology
https://www.readbyqxmd.com/read/27463666/response-to-comment-on-a-histone-acetylation-switch-regulates-h2a-z-deposition-by-the-swr-c-remodeling-enzyme
#4
COMMENT
Shinya Watanabe, Craig L Peterson
Wang et al report a failure to reproduce our biochemical observation that the INO80C and SWR1C/SWR1/SWR-C chromatin remodeling enzymes catalyze replacement of nucleosomal H2A.Z with H2A when the substrate contains H3-K56Q. They point to technical problems with our dimer exchange assay. In response, we have recapitulated our findings using a mobility shift assay that was developed and employed by Wang and colleagues.
July 22, 2016: Science
https://www.readbyqxmd.com/read/27012580/assessing-cardiac-metabolism-a-scientific-statement-from-the-american-heart-association
#5
Heinrich Taegtmeyer, Martin E Young, Gary D Lopaschuk, E Dale Abel, Henri Brunengraber, Victor Darley-Usmar, Christine Des Rosiers, Robert Gerszten, Jan F Glatz, Julian L Griffin, Robert J Gropler, Hermann-Georg Holzhuetter, Jorge R Kizer, E Douglas Lewandowski, Craig R Malloy, Stefan Neubauer, Linda R Peterson, Michael A Portman, Fabio A Recchia, Jennifer E Van Eyk, Thomas J Wang
In a complex system of interrelated reactions, the heart converts chemical energy to mechanical energy. Energy transfer is achieved through coordinated activation of enzymes, ion channels, and contractile elements, as well as structural and membrane proteins. The heart's needs for energy are difficult to overestimate. At a time when the cardiovascular research community is discovering a plethora of new molecular methods to assess cardiac metabolism, the methods remain scattered in the literature. The present statement on "Assessing Cardiac Metabolism" seeks to provide a collective and curated resource on methods and models used to investigate established and emerging aspects of cardiac metabolism...
May 13, 2016: Circulation Research
https://www.readbyqxmd.com/read/26755552/digoxin-use-is-associated-with-reduced-interstage-mortality-in-patients-with-no-history-of-arrhythmia-after-stage-i-palliation-for-single-ventricle-heart-disease
#6
MULTICENTER STUDY
David W Brown, Colleen Mangeot, Jeffrey B Anderson, Laura E Peterson, Eileen C King, Stacey L Lihn, Steven R Neish, Craig Fleishman, Christina Phelps, Samuel Hanke, Robert H Beekman, Carole M Lannon
BACKGROUND: Interstage mortality (IM) remains significant after stage 1 palliation (S1P) for single-ventricle heart disease (SVD), with many deaths sudden and unexpected. We sought to determine whether digoxin use post-S1P is associated with reduced IM, utilizing the multicenter database of the National Pediatric Cardiology Quality Improvement Collaborative (NPCQIC). METHODS AND RESULTS: From June 2008 to July 2013, 816 infants discharged after S1P from 50 surgical sites completed the interstage to stage II palliation, transplant, or IM...
January 11, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/26636426/evaluating-potential-iatrogenic-suicide-risk-in-trauma-focused-group-cognitive-behavioral-therapy-for-the-treatment-of-ptsd-in-active-duty-military-personnel
#7
Craig J Bryan, Tracy A Clemans, Ann Marie Hernandez, Jim Mintz, Alan L Peterson, Jeffrey S Yarvis, Patricia A Resick
OBJECTIVE: To determine whether group cognitive processing therapy-cognitive only version (CPT-C) is associated with iatrogenic suicide risk in a sample of active duty US Army personnel diagnosed with posttraumatic stress disorder (PTSD). Possible iatrogenic effects considered include the incidence and severity of suicide ideation, worsening of preexisting suicide ideation, incidence of new-onset suicide ideation, and incidence of suicide attempts among soldiers receiving group CPT-C...
June 2016: Depression and Anxiety
https://www.readbyqxmd.com/read/26586442/chromatin-dynamics-and-the-rna-exosome-function-in-concert-to-regulate-transcriptional-homeostasis
#8
Mayuri Rege, Vidya Subramanian, Chenchen Zhu, Tsung-Han S Hsieh, Assaf Weiner, Nir Friedman, Sandra Clauder-Münster, Lars M Steinmetz, Oliver J Rando, Laurie A Boyer, Craig L Peterson
The histone variant H2A.Z is a hallmark of nucleosomes flanking promoters of protein-coding genes and is often found in nucleosomes that carry lysine 56-acetylated histone H3 (H3-K56Ac), a mark that promotes replication-independent nucleosome turnover. Here, we find that H3-K56Ac promotes RNA polymerase II occupancy at many protein-coding and noncoding loci, yet neither H3-K56Ac nor H2A.Z has a significant impact on steady-state mRNA levels in yeast. Instead, broad effects of H3-K56Ac or H2A.Z on RNA levels are revealed only in the absence of the nuclear RNA exosome...
November 24, 2015: Cell Reports
https://www.readbyqxmd.com/read/26519833/treatment-of-active-duty-military-with-ptsd-in-primary-care-a-follow-up-report
#9
Jeffrey A Cigrang, Sheila A M Rauch, Jim Mintz, Antoinette Brundige, Laura L Avila, Craig J Bryan, Jeffrey L Goodie, Alan L Peterson
First-line trauma-focused therapies offered in specialty mental health clinics do not reach many veterans and active duty service members with posttraumatic stress disorder (PTSD). Primary care is an ideal environment to expand access to mental health care. Several promising clinical case series reports of brief PTSD therapies adapted for primary care have shown positive results, but the long-term effectiveness with military members is unknown. The purpose of this study was to determine the long-term outcome of an open trial of a brief cognitive-behavioral primary care-delivered protocol developed specifically for deployment-related PTSD in a sample of 24 active duty military (15 men, 9 women)...
December 2015: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/26446094/health-related-quality-of-life-in-two-randomized-controlled-trials-of-phentermine-topiramate-for-obesity-what-mediates-improvement
#10
Ronette L Kolotkin, Kishore M Gadde, Craig A Peterson, Ross D Crosby
PURPOSE: Phentermine/topiramate combination therapy resulted in significant weight loss and improvements in cardiometabolic risk factors in patients with obesity/overweight in two published 56-week randomized, placebo-controlled trials (EQUIP and CONQUER). The purpose of the current study was to examine whether phentermine/topiramate is also associated with greater improvements in health-related quality of life (HRQOL) and whether HRQOL improvements are solely attributable to weight reduction...
May 2016: Quality of Life Research
https://www.readbyqxmd.com/read/26359490/climatic-niche-and-flowering-and-fruiting-phenology-of-an-epiphytic-plant
#11
Narayani Barve, Craig E Martin, A Townsend Peterson
Species have geographic distributions constrained by combinations of abiotic factors, biotic factors and dispersal-related factors. Abiotic requirements vary across the life stages for a species; for plant species, a particularly important life stage is when the plant flowers and develops seeds. A previous year-long experiment showed that ambient temperature of 5-35 °C, relative humidity of >50 % and ≤15 consecutive rainless days are crucial abiotic conditions for Spanish moss (Tillandsia usneoides L...
2015: AoB Plants
https://www.readbyqxmd.com/read/26140131/transforming-ward-rounds-through-rounding-in-flow
#12
Alvin S Calderon, C Craig Blackmore, Barbara L Williams, Kavita P Chawla, Dana L Nelson-Peterson, Michael D Ingraham, Donna L Smith, Gary S Kaplan
BACKGROUND: Traditional "batched" bedside clinical care rounds, where rounds for all patients precede clinical tasks, may delay clinical care and reduce resident work efficiency. INNOVATION: Using Lean concepts, we developed a novel "Rounding-in-Flow" approach, with the patient care team completing all tasks for a single patient before initiating any tasks for the next patient. Outcome measures included timely patient discharge and intern work hours. METHODS: We performed a retrospective cohort study with historic and contemporaneous control groups, with time series adjustment for underlying temporal trends at a single medical center...
December 2014: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/26101714/melanoma-patient-derived-xenografts-acquire-distinct-vemurafenib-resistance-mechanisms
#13
David J Monsma, David M Cherba, Emily E Eugster, Dawna L Dylewski, Paula T Davidson, Chelsea A Peterson, Andrew S Borgman, Mary E Winn, Karl J Dykema, Craig P Webb, Jeffrey P MacKeigan, Nicholas S Duesbery, Brian J Nickoloff, Noel R Monks
Variable clinical responses, tumor heterogeneity, and drug resistance reduce long-term survival outcomes for metastatic melanoma patients. To guide and accelerate drug development, we characterized tumor responses for five melanoma patient derived xenograft models treated with Vemurafenib. Three BRAF(V600E) models showed acquired drug resistance, one BRAF(V600E) model had a complete and durable response, and a BRAF(V600V) model was expectedly unresponsive. In progressing tumors, a variety of resistance mechanisms to BRAF inhibition were uncovered, including mutant BRAF alternative splicing, NRAS mutation, COT (MAP3K8) overexpression, and increased mutant BRAF gene amplification and copy number...
2015: American Journal of Cancer Research
https://www.readbyqxmd.com/read/26091169/single-amino-acid-variation-underlies-species-specific-sensitivity-to-amphibian-skin-derived-opioid-like-peptides
#14
Eyal Vardy, Maria F Sassano, Andrew J Rennekamp, Wesley K Kroeze, Philip D Mosier, Richard B Westkaemper, Craig W Stevens, Vsevolod Katritch, Raymond C Stevens, Randall T Peterson, Bryan L Roth
It has been suggested that the evolution of vertebrate opioid receptors (ORs) follow a vector of increased functionality. Here, we test this idea by comparing human and frog ORs. Interestingly, some of the most potent opioid peptides known have been isolated from amphibian skin secretions. Here we show that such peptides (dermorphin and deltorphin) are highly potent in the human receptors and inactive in frog ORs. The molecular basis for the insensitivity of the frog ORs to these peptides was studied using chimeras and molecular modeling...
June 18, 2015: Chemistry & Biology
https://www.readbyqxmd.com/read/25997164/a-multilaboratory-comparison-of-calibration-accuracy-and-the-performance-of-external-references-in-analytical-ultracentrifugation
#15
Huaying Zhao, Rodolfo Ghirlando, Carlos Alfonso, Fumio Arisaka, Ilan Attali, David L Bain, Marina M Bakhtina, Donald F Becker, Gregory J Bedwell, Ahmet Bekdemir, Tabot M D Besong, Catherine Birck, Chad A Brautigam, William Brennerman, Olwyn Byron, Agnieszka Bzowska, Jonathan B Chaires, Catherine T Chaton, Helmut Cölfen, Keith D Connaghan, Kimberly A Crowley, Ute Curth, Tina Daviter, William L Dean, Ana I Díez, Christine Ebel, Debra M Eckert, Leslie E Eisele, Edward Eisenstein, Patrick England, Carlos Escalante, Jeffrey A Fagan, Robert Fairman, Ron M Finn, Wolfgang Fischle, José García de la Torre, Jayesh Gor, Henning Gustafsson, Damien Hall, Stephen E Harding, José G Hernández Cifre, Andrew B Herr, Elizabeth E Howell, Richard S Isaac, Shu-Chuan Jao, Davis Jose, Soon-Jong Kim, Bashkim Kokona, Jack A Kornblatt, Dalibor Kosek, Elena Krayukhina, Daniel Krzizike, Eric A Kusznir, Hyewon Kwon, Adam Larson, Thomas M Laue, Aline Le Roy, Andrew P Leech, Hauke Lilie, Karolin Luger, Juan R Luque-Ortega, Jia Ma, Carrie A May, Ernest L Maynard, Anna Modrak-Wojcik, Yee-Foong Mok, Norbert Mücke, Luitgard Nagel-Steger, Geeta J Narlikar, Masanori Noda, Amanda Nourse, Tomas Obsil, Chad K Park, Jin-Ku Park, Peter D Pawelek, Erby E Perdue, Stephen J Perkins, Matthew A Perugini, Craig L Peterson, Martin G Peverelli, Grzegorz Piszczek, Gali Prag, Peter E Prevelige, Bertrand D E Raynal, Lenka Rezabkova, Klaus Richter, Alison E Ringel, Rose Rosenberg, Arthur J Rowe, Arne C Rufer, David J Scott, Javier G Seravalli, Alexandra S Solovyova, Renjie Song, David Staunton, Caitlin Stoddard, Katherine Stott, Holger M Strauss, Werner W Streicher, John P Sumida, Sarah G Swygert, Roman H Szczepanowski, Ingrid Tessmer, Ronald T Toth, Ashutosh Tripathy, Susumu Uchiyama, Stephan F W Uebel, Satoru Unzai, Anna Vitlin Gruber, Peter H von Hippel, Christine Wandrey, Szu-Huan Wang, Steven E Weitzel, Beata Wielgus-Kutrowska, Cynthia Wolberger, Martin Wolff, Edward Wright, Yu-Sung Wu, Jacinta M Wubben, Peter Schuck
Analytical ultracentrifugation (AUC) is a first principles based method to determine absolute sedimentation coefficients and buoyant molar masses of macromolecules and their complexes, reporting on their size and shape in free solution. The purpose of this multi-laboratory study was to establish the precision and accuracy of basic data dimensions in AUC and validate previously proposed calibration techniques. Three kits of AUC cell assemblies containing radial and temperature calibration tools and a bovine serum albumin (BSA) reference sample were shared among 67 laboratories, generating 129 comprehensive data sets...
2015: PloS One
https://www.readbyqxmd.com/read/25964121/structural-analyses-of-the-chromatin-remodelling-enzymes-ino80-c-and-swr-c
#16
Shinya Watanabe, Dongyan Tan, Mahadevan Lakshminarasimhan, Michael P Washburn, Eun-Jin Erica Hong, Thomas Walz, Craig L Peterson
INO80-C and SWR-C are conserved members of a subfamily of ATP-dependent chromatin remodelling enzymes that function in transcription and genome-maintenance pathways. A crucial role for these enzymes is to control chromosomal distribution of the H2A.Z histone variant. Here we use electron microscopy (EM) and two-dimensional class averaging to demonstrate that these remodelling enzymes have similar overall architectures. Each enzyme is characterized by a dynamic 'tail' domain and a compact 'head' that contains Rvb1/Rvb2 subunits organized as hexameric rings...
2015: Nature Communications
https://www.readbyqxmd.com/read/25959393/the-histone-chaperones-fact-and-spt6-restrict-h2a-z-from-intragenic-locations
#17
Célia Jeronimo, Shinya Watanabe, Craig D Kaplan, Craig L Peterson, François Robert
H2A.Z is a highly conserved histone variant involved in several key nuclear processes. It is incorporated into promoters by SWR-C-related chromatin remodeling complexes, but whether it is also actively excluded from non-promoter regions is not clear. Here we provide genomic and biochemical evidence that the RNA polymerase II (RNA Pol II) elongation-associated histone chaperones FACT and Spt6 both contribute to restricting H2A.Z from intragenic regions. In the absence of FACT or Spt6, the lack of efficient nucleosome reassembly coupled to pervasive incorporation of H2A...
June 18, 2015: Molecular Cell
https://www.readbyqxmd.com/read/25869823/swi-snf-recruitment-to-a-dna-double-strand-break-by-the-nua4-and-gcn5-histone-acetyltransferases
#18
Gwendolyn Bennett, Craig L Peterson
The DNA damage response to double-strand breaks (DSBs) is critical for cellular viability. Recent work has shown that a host of chromatin regulators are recruited to a DSB, and that they are important for the DNA damage response. However, the functional relationships between different chromatin regulators at DSBs remain unclear. Here we describe a conserved functional interaction among the chromatin remodeling enzyme, SWI/SNF, the NuA4 and Gcn5 histone acetyltransferases, and phosphorylation of histone H2A...
June 2015: DNA Repair
https://www.readbyqxmd.com/read/25691465/the-ino80-complex-prevents-invasion-of-euchromatin-into-silent-chromatin
#19
Yong Xue, Christopher Van, Suman K Pradhan, Trent Su, Jason Gehrke, Benjamin G Kuryan, Tasuku Kitada, Ajay Vashisht, Nancy Tran, James Wohlschlegel, Craig L Peterson, Siavash K Kurdistani, Michael F Carey
Here we show that the Ino80 chromatin remodeling complex (Ino80C) directly prevents euchromatin from invading transcriptionally silent chromatin within intergenic regions and at the border of euchromatin and heterochromatin. Deletion of Ino80C subunits leads to increased H3K79 methylation and noncoding RNA polymerase II (Pol II) transcription centered at the Ino80C-binding sites. The effect of Ino80C is direct, as it blocks H3K79 methylation by Dot1 in vitro. Heterochromatin stimulates the binding of Ino80C in vitro and in vivo...
February 15, 2015: Genes & Development
https://www.readbyqxmd.com/read/25677353/brief-cognitive-behavioral-therapy-effects-on-post-treatment-suicide-attempts-in-a-military-sample-results-of-a-randomized-clinical-trial-with-2-year-follow-up
#20
RANDOMIZED CONTROLLED TRIAL
M David Rudd, Craig J Bryan, Evelyn G Wertenberger, Alan L Peterson, Stacey Young-McCaughan, Jim Mintz, Sean R Williams, Kimberly A Arne, Jill Breitbach, Kenneth Delano, Erin Wilkinson, Travis O Bruce
OBJECTIVE: The authors evaluated the effectiveness of brief cognitive-behavioral therapy (CBT) for the prevention of suicide attempts in military personnel. METHOD: In a randomized controlled trial, active-duty Army soldiers at Fort Carson, Colo., who either attempted suicide or experienced suicidal ideation with intent, were randomly assigned to treatment as usual (N=76) or treatment as usual plus brief CBT (N=76). Assessment of incidence of suicide attempts during the follow-up period was conducted with the Suicide Attempt Self-Injury Interview...
May 2015: American Journal of Psychiatry
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