keyword
MENU ▼
Read by QxMD icon Read
search

Craig L. Peterson

keyword
https://www.readbyqxmd.com/read/28530639/calcium-binding-protein-s100a4-confers-mesenchymal-progenitor-cell-fibrogenicity-in-idiopathic-pulmonary-fibrosis
#1
Hong Xia, Adam Gilbertsen, Jeremy Herrera, Emilian Racila, Karen Smith, Mark Peterson, Timothy Griffin, Alexey Benyumov, Libang Yang, Peter B Bitterman, Craig A Henke
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a prevalence of 1 million persons worldwide. The fibrosis spreads from affected alveoli into contiguous alveoli and leads to death by asphyxiation. We previously discovered that the IPF lung harbors fibrogenic mesenchymal progenitor cells (MPCs) that serve as a cell of origin for disease-mediating myofibroblasts. In a prior genomewide transcriptional analysis, we found that IPF MPCs displayed increased expression of S100 calcium-binding A4 (S100A4), a protein linked to cancer cell proliferation and invasiveness...
May 22, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28512350/mechanisms-of-action-and-regulation-of-atp-dependent-chromatin-remodelling-complexes
#2
REVIEW
Cedric R Clapier, Janet Iwasa, Bradley R Cairns, Craig L Peterson
Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out histone sliding, ejection or the incorporation of histone variants, suggesting that different mechanisms of action are used by the various chromatin-remodelling complex subfamilies. However, all chromatin-remodelling complex subfamilies contain an ATPase-translocase 'motor' that translocates DNA from a common location within the nucleosome. In this Review, we discuss (and illustrate with animations) an alternative, unifying mechanism of chromatin remodelling, which is based on the regulation of DNA translocation...
July 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28452888/the-impact-of-patient-weight-on-burn-resuscitation
#3
Nehemiah T Liu, Craig A Fenrich, Maria L Serio-Melvin, Wylan C Peterson, Leopoldo C Cancio, José Salinas
BACKGROUND: Optimal fluid resuscitation of burn patients with burns greater than 20% total body surface area is critical to prevent burn shock during the initial 24 hours to 48 hours postburn. Currently, most resuscitation formulas incorporate the patient's weight when estimating 24-hour fluid requirements. The objective of this study was to determine the impact of weight on fluid resuscitation requirements and outcomes during the initial 24 hours after admission. METHODS: We performed a retrospective review of patients admitted to our burn intensive care unit from December 2007 to April 2013, resuscitated with a computerized decision support system...
July 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28441958/metformin-to-augment-strength-training-effective-response-in-seniors-masters-study-protocol-for-a-randomized-controlled-trial
#4
Doug E Long, Bailey D Peck, Jenny L Martz, S Craig Tuggle, Heather M Bush, Gerald McGwin, Philip A Kern, Marcas M Bamman, Charlotte A Peterson
BACKGROUND: Muscle mass and strength are strong determinants of a person's quality of life and functional independence with advancing age. While resistance training is the most effective intervention to combat age-associated muscle atrophy (sarcopenia), the ability of older adults to increase muscle mass and strength in response to training is blunted and highly variable. Thus, finding novel ways to complement resistance training to improve muscle response and ultimately quality of life among older individuals is critical...
April 26, 2017: Trials
https://www.readbyqxmd.com/read/28422576/mechanisms-of-action-contributing-to-reductions-in-suicide-attempts-following-brief-cognitive-behavioral-therapy-for-military-personnel-a-test-of-the-interpersonal-psychological-theory-of-suicide
#5
Craig J Bryan, David S Wood, Alexis May, Alan L Peterson, Evelyn Wertenberger, M David Rudd
Brief cognitive behavioral therapy (BCBT) is associated with significant reductions in suicide attempts among military personnel. However, the underlying mechanisms of action contributing to reductions in suicide attempts in effective psychological treatments remain largely unknown. The present study conducted a secondary analysis of a randomized controlled trial of BCBT versus treatment as usual (TAU) to examine the mechanisms of action hypothesized by the interpersonal-psychological theory of suicide (IPT): perceived burdensomeness, thwarted belongingness, and fearlessness about death...
April 19, 2017: Archives of Suicide Research: Official Journal of the International Academy for Suicide Research
https://www.readbyqxmd.com/read/28359770/evaluation-of-cell-viability-dyes-in-antiviral-assays-with-rna-viruses-that-exhibit-different-cytopathogenic-properties
#6
Donald F Smee, Brett L Hurst, W Joseph Evans, Nathan Clyde, Sean Wright, Christopher Peterson, Kie-Hoon Jung, Craig W Day
Studies were conducted to determine the performance of four dyes in assessing antiviral activities of compounds against three RNA viruses with differing cytopathogenic properties. Dyes included alamarBlue(®) measured by absorbance (ALB-A) and fluorescence (ALB-F), neutral red (NR), Viral ToxGlo™ (VTG), and WST-1. Viruses were chikungunya, dengue type 2, and Junin, which generally cause 100, 80-90, and 50% maximal cytopathic effect (CPE), respectively, in Vero or Vero 76 cells Compounds evaluated were 6-azauridine, BCX-4430, 3-deazaguanine, EICAR, favipiravir, infergen, mycophenolic acid (MPA), ribavirin, and tiazofurin...
August 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28322723/nucleosomes-influence-multiple-steps-during-replication-initiation
#7
Ishara F Azmi, Shinya Watanabe, Michael F Maloney, Sukhyun Kang, Jason A Belsky, David M MacAlpine, Craig L Peterson, Stephen P Bell
Eukaryotic replication origin licensing, activation and timing are influenced by chromatin but a mechanistic understanding is lacking. Using reconstituted nucleosomal DNA replication assays, we assessed the impact of nucleosomes on replication initiation. To generate distinct nucleosomal landscapes, different chromatin-remodeling enzymes (CREs) were used to remodel nucleosomes on origin-DNA templates. Nucleosomal organization influenced two steps of replication initiation: origin licensing and helicase activation...
March 21, 2017: ELife
https://www.readbyqxmd.com/read/28202543/nucleosome-like-single-stranded-dna-ssdna-histone-octamer-complexes-and-the-implication-for-dna-double-strand-break-repair
#8
Nicholas L Adkins, Sarah G Swygert, Parminder Kaur, Hengyao Niu, Sergei A Grigoryev, Patrick Sung, Hong Wang, Craig L Peterson
Repair of DNA double strand breaks (DSBs) is key for maintenance of genome integrity. When DSBs are repaired by homologous recombination, DNA ends can undergo extensive processing, producing long stretches of single-stranded DNA (ssDNA). In vivo, DSB processing occurs in the context of chromatin, and studies indicate that histones may remain associated with processed DSBs. Here we demonstrate that histones are not evicted from ssDNA after in vitro chromatin resection. In addition, we reconstitute histone-ssDNA complexes (termed ssNucs) with ssDNA and recombinant histones and analyze these particles by a combination of native gel electrophoresis, sedimentation velocity, electron microscopy, and a recently developed electrostatic force microscopy technique, DREEM (dual-resonance frequency-enhanced electrostatic force microscopy)...
March 31, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27818141/hsp90-and-p23-molecular-chaperones-control-chromatin-architecture-by-maintaining-the-functional-pool-of-the-rsc-chromatin-remodeler
#9
Frank J Echtenkamp, Zlata Gvozdenov, Nicholas L Adkins, Yang Zhang, Melinda Lynch-Day, Shinya Watanabe, Craig L Peterson, Brian C Freeman
Molecular chaperones govern protein homeostasis, being allied to the beginning (folding) and ending (degradation) of the protein life cycle. Yet, the Hsp90 system primarily associates with native factors, including fully assembled complexes. The significance of these connections is poorly understood. To delineate why Hsp90 and its cochaperone p23 interact with a mature structure, we focused on the RSC chromatin remodeler. Both Hsp90 and p23 triggered the release of RSC from DNA or a nucleosome. Although Hsp90 only freed bound RSC, p23 enhanced nucleosome remodeling prior to discharging the complex...
December 1, 2016: Molecular Cell
https://www.readbyqxmd.com/read/27768892/genomic-nucleosome-organization-reconstituted-with-pure-proteins
#10
Nils Krietenstein, Megha Wal, Shinya Watanabe, Bongsoo Park, Craig L Peterson, B Franklin Pugh, Philipp Korber
Chromatin remodelers regulate genes by organizing nucleosomes around promoters, but their individual contributions are obfuscated by the complex in vivo milieu of factor redundancy and indirect effects. Genome-wide reconstitution of promoter nucleosome organization with purified proteins resolves this problem and is therefore a critical goal. Here, we reconstitute four stages of nucleosome architecture using purified components: yeast genomic DNA, histones, sequence-specific Abf1/Reb1, and remodelers RSC, ISW2, INO80, and ISW1a...
October 20, 2016: Cell
https://www.readbyqxmd.com/read/27578267/rna-polymerase-ii-depletion-promotes-transcription-of-alternative-mrna-species
#11
Lijian Yu, Mayuri Rege, Craig L Peterson, Michael R Volkert
BACKGROUND: Cells respond to numerous internal and external stresses, such as heat, cold, oxidative stress, DNA damage, and osmotic pressure changes. In most cases, the primary response to stress is transcriptional induction of genes that assist the cells in tolerating the stress and facilitate the repair of the cellular damage. However, when the transcription machinery itself is stressed, responding by such standard mechanisms may not be possible. RESULTS: In this study, we demonstrate that depletion or inactivation of RNA polymerase II (RNAPII) changes the preferred polyadenylation site usage for several transcripts, and leads to increased transcription of a specific subset of genes...
2016: BMC Molecular Biology
https://www.readbyqxmd.com/read/27463666/response-to-comment-on-a-histone-acetylation-switch-regulates-h2a-z-deposition-by-the-swr-c-remodeling-enzyme
#12
COMMENT
Shinya Watanabe, Craig L Peterson
Wang et al report a failure to reproduce our biochemical observation that the INO80C and SWR1C/SWR1/SWR-C chromatin remodeling enzymes catalyze replacement of nucleosomal H2A.Z with H2A when the substrate contains H3-K56Q. They point to technical problems with our dimer exchange assay. In response, we have recapitulated our findings using a mobility shift assay that was developed and employed by Wang and colleagues.
July 22, 2016: Science
https://www.readbyqxmd.com/read/27012580/assessing-cardiac-metabolism-a-scientific-statement-from-the-american-heart-association
#13
REVIEW
Heinrich Taegtmeyer, Martin E Young, Gary D Lopaschuk, E Dale Abel, Henri Brunengraber, Victor Darley-Usmar, Christine Des Rosiers, Robert Gerszten, Jan F Glatz, Julian L Griffin, Robert J Gropler, Hermann-Georg Holzhuetter, Jorge R Kizer, E Douglas Lewandowski, Craig R Malloy, Stefan Neubauer, Linda R Peterson, Michael A Portman, Fabio A Recchia, Jennifer E Van Eyk, Thomas J Wang
In a complex system of interrelated reactions, the heart converts chemical energy to mechanical energy. Energy transfer is achieved through coordinated activation of enzymes, ion channels, and contractile elements, as well as structural and membrane proteins. The heart's needs for energy are difficult to overestimate. At a time when the cardiovascular research community is discovering a plethora of new molecular methods to assess cardiac metabolism, the methods remain scattered in the literature. The present statement on "Assessing Cardiac Metabolism" seeks to provide a collective and curated resource on methods and models used to investigate established and emerging aspects of cardiac metabolism...
May 13, 2016: Circulation Research
https://www.readbyqxmd.com/read/26755552/digoxin-use-is-associated-with-reduced-interstage-mortality-in-patients-with-no-history-of-arrhythmia-after-stage-i-palliation-for-single-ventricle-heart-disease
#14
MULTICENTER STUDY
David W Brown, Colleen Mangeot, Jeffrey B Anderson, Laura E Peterson, Eileen C King, Stacey L Lihn, Steven R Neish, Craig Fleishman, Christina Phelps, Samuel Hanke, Robert H Beekman, Carole M Lannon
BACKGROUND: Interstage mortality (IM) remains significant after stage 1 palliation (S1P) for single-ventricle heart disease (SVD), with many deaths sudden and unexpected. We sought to determine whether digoxin use post-S1P is associated with reduced IM, utilizing the multicenter database of the National Pediatric Cardiology Quality Improvement Collaborative (NPCQIC). METHODS AND RESULTS: From June 2008 to July 2013, 816 infants discharged after S1P from 50 surgical sites completed the interstage to stage II palliation, transplant, or IM...
January 11, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/26636426/evaluating-potential-iatrogenic-suicide-risk-in-trauma-focused-group-cognitive-behavioral-therapy-for-the-treatment-of-ptsd-in-active-duty-military-personnel
#15
Craig J Bryan, Tracy A Clemans, Ann Marie Hernandez, Jim Mintz, Alan L Peterson, Jeffrey S Yarvis, Patricia A Resick
OBJECTIVE: To determine whether group cognitive processing therapy-cognitive only version (CPT-C) is associated with iatrogenic suicide risk in a sample of active duty US Army personnel diagnosed with posttraumatic stress disorder (PTSD). Possible iatrogenic effects considered include the incidence and severity of suicide ideation, worsening of preexisting suicide ideation, incidence of new-onset suicide ideation, and incidence of suicide attempts among soldiers receiving group CPT-C...
June 2016: Depression and Anxiety
https://www.readbyqxmd.com/read/26586442/chromatin-dynamics-and-the-rna-exosome-function-in-concert-to-regulate-transcriptional-homeostasis
#16
Mayuri Rege, Vidya Subramanian, Chenchen Zhu, Tsung-Han S Hsieh, Assaf Weiner, Nir Friedman, Sandra Clauder-Münster, Lars M Steinmetz, Oliver J Rando, Laurie A Boyer, Craig L Peterson
The histone variant H2A.Z is a hallmark of nucleosomes flanking promoters of protein-coding genes and is often found in nucleosomes that carry lysine 56-acetylated histone H3 (H3-K56Ac), a mark that promotes replication-independent nucleosome turnover. Here, we find that H3-K56Ac promotes RNA polymerase II occupancy at many protein-coding and noncoding loci, yet neither H3-K56Ac nor H2A.Z has a significant impact on steady-state mRNA levels in yeast. Instead, broad effects of H3-K56Ac or H2A.Z on RNA levels are revealed only in the absence of the nuclear RNA exosome...
November 24, 2015: Cell Reports
https://www.readbyqxmd.com/read/26519833/treatment-of-active-duty-military-with-ptsd-in-primary-care-a-follow-up-report
#17
Jeffrey A Cigrang, Sheila A M Rauch, Jim Mintz, Antoinette Brundige, Laura L Avila, Craig J Bryan, Jeffrey L Goodie, Alan L Peterson
First-line trauma-focused therapies offered in specialty mental health clinics do not reach many veterans and active duty service members with posttraumatic stress disorder (PTSD). Primary care is an ideal environment to expand access to mental health care. Several promising clinical case series reports of brief PTSD therapies adapted for primary care have shown positive results, but the long-term effectiveness with military members is unknown. The purpose of this study was to determine the long-term outcome of an open trial of a brief cognitive-behavioral primary care-delivered protocol developed specifically for deployment-related PTSD in a sample of 24 active duty military (15 men, 9 women)...
December 2015: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/26446094/health-related-quality-of-life-in-two-randomized-controlled-trials-of-phentermine-topiramate-for-obesity-what-mediates-improvement
#18
Ronette L Kolotkin, Kishore M Gadde, Craig A Peterson, Ross D Crosby
PURPOSE: Phentermine/topiramate combination therapy resulted in significant weight loss and improvements in cardiometabolic risk factors in patients with obesity/overweight in two published 56-week randomized, placebo-controlled trials (EQUIP and CONQUER). The purpose of the current study was to examine whether phentermine/topiramate is also associated with greater improvements in health-related quality of life (HRQOL) and whether HRQOL improvements are solely attributable to weight reduction...
May 2016: Quality of Life Research
https://www.readbyqxmd.com/read/26359490/climatic-niche-and-flowering-and-fruiting-phenology-of-an-epiphytic-plant
#19
Narayani Barve, Craig E Martin, A Townsend Peterson
Species have geographic distributions constrained by combinations of abiotic factors, biotic factors and dispersal-related factors. Abiotic requirements vary across the life stages for a species; for plant species, a particularly important life stage is when the plant flowers and develops seeds. A previous year-long experiment showed that ambient temperature of 5-35 °C, relative humidity of >50 % and ≤15 consecutive rainless days are crucial abiotic conditions for Spanish moss (Tillandsia usneoides L...
2015: AoB Plants
https://www.readbyqxmd.com/read/26140131/transforming-ward-rounds-through-rounding-in-flow
#20
Alvin S Calderon, C Craig Blackmore, Barbara L Williams, Kavita P Chawla, Dana L Nelson-Peterson, Michael D Ingraham, Donna L Smith, Gary S Kaplan
BACKGROUND: Traditional "batched" bedside clinical care rounds, where rounds for all patients precede clinical tasks, may delay clinical care and reduce resident work efficiency. INNOVATION: Using Lean concepts, we developed a novel "Rounding-in-Flow" approach, with the patient care team completing all tasks for a single patient before initiating any tasks for the next patient. Outcome measures included timely patient discharge and intern work hours. METHODS: We performed a retrospective cohort study with historic and contemporaneous control groups, with time series adjustment for underlying temporal trends at a single medical center...
December 2014: Journal of Graduate Medical Education
keyword
keyword
97405
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"