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Staphyloccus aureus

Nabila Moussa Slimane, Zakaria Bouhidel, Aouatef Cherouana
The title Schiff base compound, C15 H13 NO2 , crystallizes in a new crystal form in the space group P 21 21 21 , which is different from the monoclinic P 21 / n space group reported previously [De et al. (2009 ▸). Indian J. Chem. Sect. B , 48 , 595-598]. An intra-molecular O-H⋯N hydrogen bond occurs between the hy-droxy and azomethine moieties. In the crystal, mol-ecules are linked by weak C-H⋯O hydrogen bonds into supra-molecular chains propagating along the b -axis direction with a C (8) graph-set motif...
July 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
Mahmoud H Abu Elella, Riham R Mohamed, Eman Abd ElHafeez, Magdy W Sabaa
Xanthan gum (XG) is natural polysaccharides used in food industries as stabilizers and thickener agents. The problem is that some food products are found to be contaminated by pathogenic bacteria such as Escherichia coli (E. coli) and Staphyloccus aureus (S. aureus) that reduce their shelf life. This research aims to synthesize biodegradable antibacterial XG-grafted-poly(N-vinyl imidazole) PVI and the effect of reaction parameters were studied on grafting yield (G), grafting efficiency (GE), total conversion (TC) and homopolymer (H) %...
October 1, 2017: Carbohydrate Polymers
Hanne Amdahl, Karita Haapasalo, Lydia Tan, Taru Meri, Pentti I Kuusela, Jos A van Strijp, Suzan Rooijakkers, T Sakari Jokiranta
Staphyloccus aureus is a major human pathogen leading frequently to sepsis and soft tissue infections with abscesses. Multiple virulence factors including several immune modulating molecules contribute to its survival in the host. When S. aureus invades the human body, one of the first line defenses is the complement system, which opsonizes the bacteria with C3b and attract neutrophils by release of chemotactic peptides. Neutrophils express Complement receptor-1 [CR1, CD35) that interacts with the C3b-opsonized particles and thereby plays an important role in pathogen recognition by phagocytic cells...
2017: PloS One
Retno Wahyuningrum, Pri Iswati Utami, Binar Asrining Dhiani, Malikhah Kumalasari, Rizka Sari Kusumawardani
Purwoceng (Pimpinella alpina Molk) is a traditional medicinal plant used for its aphrodisiac values. This plant was originated Dieng Plateu, Central Java, Indonesia. Purwoceng has been reported to contain steroid, flavonoids, glycoside, saponins, tannins, and phenolic. Based on secondary metabolite compounds of Purwoceng herbs, a research need to be done to determine the other potential free radicals scavenger and antibacterial activities of Purwoceng. The objectives of this research are to screen the potential free radicals scavenger activity of in vitro using DPPH (1,1 diphenyl-2-picryl-hydrazil) radicals and NO• (nitric oxide) radicals, and antibacterial activity of Purwoceng...
November 2016: Tropical Life Sciences Research
J A Capdevila, M Guembe, J Barberán, A de Alarcón, E Bouza, M C Fariñas, J Gálvez, M A Goenaga, F Gutiérrez, M Kestler, P Llinares, J M Miró, M Montejo, P Muñoz, M Rodríguez-Creixems, D Sousa, J Cuenca, C A Mestres
The use of endovascular catheters is a routine practice in secondary and tertiary care level hospitals. Short peripheral catheters have been found to be associated with the risk of nosocomial bacteremia resulting in morbidity and mortality. Staphyloccus aureus is mostly associated with peripheral catheter insertion. This Consensus Document has been elaborated by a panel of experts of the Spanish Society of Cardiovascular Infections in cooperation with experts from the Spanish Society of Internal Medicine, Spanish Society of Chemotherapy and Spanish Society of Thoracic-Cardiovascular Surgery and aims at define and establish the norm for management of short duration peripheral vascular catheters...
August 2016: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
Jean-Jacques Dubost, Bruno Pereira, Anne Tournadre, Zuzana Tatar, Marion Couderc, Martin Soubrier
OBJECTIVES: To see whether the frequency and features of septic arthritis (SA) complicating rheumatoid arthritis (RA) have changed over the last 35years. METHODS: This retrospective single-center study included all patients hospitalized at the rheumatology department for SA bacteriologically documented by synovial fluid and/or blood culture samples. The periods 1979-2002 (before biotherapies) and 2003-2013 (the era of biotherapies) were compared. RESULTS: Between 1979 and 2013, 64/514 (12...
January 2017: Joint, Bone, Spine: Revue du Rhumatisme
Tewelde Tesfaye Gebremariam
BACKGROUND: In East Africa, particularly in Ethiopia, bacterial keratitis is a major cause of blindness. OBJECTIVE: The aims of this study were to identify risk factors of bacterial keratitis and the spectrum of bacterial etiologies, and to assess the in-vitro antimicrobial susceptibility of these bacterial isolates at Jimma University Specialized Hospital, Southwest Ethiopia. METHODS: A prospective study was employed from January 2012 to June 2012 from which a total of 24 patients with bacterial keratitis were included in the study...
October 2015: Ethiopian Medical Journal
Emily R Britton, Carolyn B Ibberson, Alexander R Horswill, Nadja B Cech
The development of drug resistance by bacterial pathogens is a growing threat. Drug resistant infections have high morbidity and mortality rates, and treatment of these infections is a major burden on the health care system. One potential strategy to prevent the development of drug resistance would be the application of therapeutic strategies that target bacterial virulence. Hyaluronidase is virulence factor that plays a role in the ability of Gram-positive bacteria such as Staphyloccus aureus and Streptococcus agalactiae to spread in tissue...
December 2015: Journal of Microbiological Methods
Alfred O Ogbemudia, Anirejuoritse Bafor, Ehimwenma J Ogbemudia, Edwin Edomwonyi
Pin-track infection (PTI) is a common complication of external fixation. Antimicrobial dressings of the pin-site interface should reduce the severity and incidence of PTI. This study is aimed at determining the efficacy of 1 % silver sulphadiazine dressings in preventing PTI in external fixation. We compared the incidence of PTI between group A (dry sterile gauze dressing) and group B (1 % silver sulphadiazine impregnated gauze dressing). PTI was diagnosed when there was: (1) redness around any pin-site, (2) tenderness near a pin-site and (3) serous or purulent discharge from the pin-skin interface...
August 2015: Strategies in Trauma and Limb Reconstruction
Shu-xiang Zhang, Min-zhi Liu, Yan Yang, Ke-di Cheng, Jian-qiang Kong, Wei Wang
Peptide cyclization, a pivotal approach to modifying linear precursors of proteins and pepticles, has been used to enhance their biological activities and serum stabilities. Recently, sortase A (SrtA) from Staphyloccus aureus becomes a promising new technology for efficiently incorporating site specific modifications into proteins, conjugating the cell surface and cyclizing the linear peptides. In this study, we constructed two recombinant expression systems, one with chitin binding domain and the other with six-histidine tag and chitin binding domain on the N-terminal of SrtA, separately...
May 2015: Yao Xue Xue Bao, Acta Pharmaceutica Sinica
Colum Downey
The purpose of this review is to establish whether there is a significantly increased incidence of serious infections during treatment for rheumatoid arthritis (RA) with etanercept, infliximab or adalimumab, to determine the background risk of serious infection in RA patients without treatment with any biological therapy and to ascertain which organisms are involved in serious infections in RA patients while being treated with etanercept, infliximab or adalimumab. Randomised controlled trials (RCTs), meta-analyses of RCTs, Cochrane reviews, national registry articles and case reports were identified using PubMed/MEDLINE, The Cochrane Library and Google Scholar...
June 2016: International Journal of Rheumatic Diseases
Ishma Aijazi, Fadhil M Abdulla, Ahmad Elbagir Ibrahim
Central Nervous System (CNS) infections like meningitis and cerebral abscess caused by Staphylococcus aureus are usually seen in patients with neurosurgical interventions or immune compromised patients or patients with cardiac vegetation's. They are extremely rare in healthy patients. We report a case of a 44 year old Indian gentleman who was perfectly healthy with no known co morbidities, which presented with fever, neck stiffness and altered mental status. He had fulminant staph bacteraemia (as evidenced by persistently positive blood cultures) with meningitis and cerebral abscess...
January 2015: Journal of Ayub Medical College, Abbottabad: JAMC
Sebastian Weis, Achim J Kaasch, Siegbert Rieg, Bettina Löffler, Stefan Hagel, Christina Forstner, Frank M Brunkhorst, Mathias W Pletz
Bacteremia caused by Methicillin-sensitive (MSSA) and Methicillin-resistant (MRSA) Staphyloccus aureus strains are common and severe infections associated with high mortality rates and specific characteristics in disease course, complications and therapy. In this review, we discuss current recommendations for the diagnosis and treatment of MSSA and MRSA bloodstream infections. We also highlight why infectious disease consultation improves the treatment and outcome of patients with SAB and should be considered as a standard of care...
June 2015: Deutsche Medizinische Wochenschrift
Tetsuro Kobayashi, Martin Glatz, Keisuke Horiuchi, Hiroshi Kawasaki, Haruhiko Akiyama, Daniel H Kaplan, Heidi H Kong, Masayuki Amagai, Keisuke Nagao
Staphylococcus aureus skin colonization is universal in atopic dermatitis and common in cancer patients treated with epidermal growth factor receptor inhibitors. However, the causal relationship of dysbiosis and eczema has yet to be clarified. Herein, we demonstrate that Adam17(fl/fl)Sox9-(Cre) mice, generated to model ADAM17-deficiency in human, developed eczematous dermatitis with naturally occurring dysbiosis, similar to that observed in atopic dermatitis. Corynebacterium mastitidis, S. aureus, and Corynebacterium bovis sequentially emerged during the onset of eczematous dermatitis, and antibiotics specific for these bacterial species almost completely reversed dysbiosis and eliminated skin inflammation...
April 21, 2015: Immunity
Edward M Kennedy, Bryan R Cullen
CRISPR/Cas systems mediate bacterial adaptive immune responses that evolved to protect bacteria from bacteriophage and other horizontally transmitted genetic elements. Several CRISPR/Cas systems exist but the simplest variant, referred to as Type II, has a single effector DNA endonuclease, called Cas9, which is guided to its viral DNA target by two small RNAs, the crRNA and the tracrRNA. Initial efforts to adapt the CRISPR/Cas system for DNA editing in mammalian cells, which focused on the Cas9 protein from Streptococcus pyogenes (Spy), demonstrated that Spy Cas9 can be directed to DNA targets in mammalian cells by tracrRNA:crRNA fusion transcripts called single guide RNAs (sgRNA)...
May 2015: Virology
A Keshmiri, G Maderbacher, C Baier, H-R Springorum, J Grifka, J Schaumburger
BACKGROUND: Surgical site infections are the most common nosocomial infections in orthopedic surgery. Strategies to prevent these infections are of enormous relevance. OBJECTIVES: Evidence-based procedures such as hand disinfection, prophylactic antibiotic application, hair removal with electric clippers, or preoperative treatment of Staphyloccus aureus are listed in national and international guidelines. Beside these measures, several scientifically not confirmed methods, e...
May 2015: Der Orthopäde
Tuan Manh Nguyen, Jaisoo Kim
A new, modified culture method that utilizes a transwell plate with a 0.4 µm pore-size microporous membrane was developed. This system allows only trace nutrients from the soil into the liquid culture through the microporous membrane. The method is a more powerful tool for the discovery of novel species from soils than are traditional methods. Such newly identified species could potentially produce useful metabolites. A bacterial strain, T515(T), was isolated using this modified culture method. Growth of strain T515(T) occurred at pH 4-9 in a temperature range between 20 °C and 40 °C and in the presence of 0-2 % (w/v) NaCl on R2A agar...
February 2015: International Journal of Systematic and Evolutionary Microbiology
Édith Duhard
Paronychia is an inflammation of the folds of tissue surrounding the nail; proximal and/or lateral nail folds. Acute paronychia is mainly due to bacterial infection, Staphyloccus aureus or Streptococcus sometimes viral infection (herpetic whitlow). Chronic paronychia is the result of numerous conditions in which the main factor is the disappearance of the cuticle. On fingers, etiology is often a contact dermatitis; bacterial or mycological infections are secondary colonizations. Onychomycosis due to moulds (Fusarium) or dematiae (Scytalidium dimitiadum) are often associated with paronychia...
November 2014: La Presse Médicale
Alberta Vandini, Robin Temmerman, Alessia Frabetti, Elisabetta Caselli, Paola Antonioli, Pier Giorgio Balboni, Daniela Platano, Alessio Branchini, Sante Mazzacane
BACKGROUND: Healthcare-Associated Infections (HAIs) are one of the most frequent complications occurring in healthcare facilities. Contaminated environmental surfaces provide an important potential source for transmission of many healthcare-associated pathogens, thus indicating the need for new and sustainable strategies. AIM: This study aims to evaluate the effect of a novel cleaning procedure based on the mechanism of biocontrol, on the presence and survival of several microorganisms responsible for HAIs (i...
2014: PloS One
Yaxin Tian, Huiliang Cao, Yuqin Qiao, Fanhao Meng, Xuanyong Liu
In this work, zero valent iron nanoparticles (Fezero-NPs) and iron oxide nanoparticles (Feox-NPs) were synthesized at the subsurface and surface regions of titanium oxide coatings (TOCs) by plasma immersion ion implantation. This novel Fe-NPs/TOC system showed negligible iron releasing, great electron storage capability and excellent cytocompatibility in vitro. Importantly, the system showed selective antibacterial ability which can kill Staphylococcus aureus under dark conditions but has no obvious antibacterial effect against Escherichia coli...
October 2014: Acta Biomaterialia
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