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https://www.readbyqxmd.com/read/28525258/bioavailability-of-soil-sorbed-tetracycline-to-escherichia-coli-under-unsaturated-conditions
#1
Zeyou Chen, Wei Zhang, Gang Wang, Yingjie Zhang, Yanzheng Gao, Stephen A Boyd, Brian J Teppen, James M Tiedje, Dongqiang Zhu, Hui Li
Increasing concentrations of anthropogenic antibiotics in soils are partly responsible for the proliferation of bacterial antibiotic resistance. However, little is known about how soil-sorbed antibiotics exert selective pressure on bacteria in unsaturated soils. This study investigated the bioavailability of tetracycline sorbed on three soils (Webster clay loam, Capac sandy clay loam, and Oshtemo loamy sand) to a fluorescent Escherichia coli bioreporter under unsaturated conditions using agar diffusion assay, microscopic visualization, and model simulation...
May 19, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28524000/the-effect-of-a-common-antibiotics-doxycycline-on-non-healing-chronic-wound
#2
Dixon H Xu, Ziwen Zhu, Yujiang Fang
Up to 25% of diabetic patients will develop a diabetic foot ulcer. Chronic wounds such as diabetic foot ulcers often fail to heal with conventional therapies. In recent years, it has been identified that chronic wounds are usually associated with elevated level of matrix metalloproteinases (MMPs). Doxycycline, a cheap tetracycline antibiotic, has been shown to inhibit MMPs both in vitro and in vivo independent of its antimicrobial property. In this review, we provide an overview of the roles of MMPs in the pathogenesis of chronic wounds and explore the potential application of doxycycline as a treatment option in managing chronic wounds such as diabetic foot ulcers...
May 18, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28522992/molecular-characterization-of-community-acquired-staphylococcus-aureus-bacteremia-in-young-children-in-southern-mozambique-2001-2009
#3
Delfino Vubil, Marcelino Garrine, Ulla Ruffing, Sozinho Acácio, Betuel Sigaúque, Pedro L Alonso, Lutz von Müller, Mathias Herrmann, Inácio Mandomando
Background: The emergence of community-acquired Staphylococcus aureus infections is increasingly recognized as life threating problem worldwide. In Manhiça district, southern Mozambique, S. aureus is the leading cause of community-acquired bacteremia in neonates. Methods: Eighty-four S. aureus isolates from children less than 5 years admitted to Manhiça District Hospital from 2001 to 2009 were randomly selected and genetically characterized by DNA microarray and spa typing. Antimicrobial susceptibility was determined by VITEK 2...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28522725/draft-genome-sequences-of-five-enterococcus-species-isolated-from-the-gut-of-patients-with-suspected-clostridium-difficile-infection
#4
Eduardo Castro-Nallar, Sandro L Valenzuela, Sebastián Baquedano, Carolina Sánchez, Fabiola Fernández, Annette N Trombert
We present draft genome sequences of five Enterococcus species from patients suspected of Clostridium difficile infection. Genome completeness was confirmed by presence of bacterial orthologs (97%). Gene searches using Hidden-Markov models revealed that the isolates harbor between seven and 11 genes involved in antibiotic resistance to tetracyclines, beta-lactams, and vancomycin.
May 18, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28521744/determination-of-the-sources-and-antimicrobial-resistance-patterns-of-salmonella-isolated-from-the-poultry-industry-in-southern-ethiopia
#5
Reta Duguma Abdi, Fisseha Mengstie, Ashenafi Feyisa Beyi, Takele Beyene, Hika Waktole, Bedasso Mammo, Dinka Ayana, Fufa Abunna
BACKGROUND: Ethiopia set an ambitious masterplan to increase chicken meat and egg production from 2015 to 2020. Poultry breeding, multiplication and distribution centers in the country have received executive order to import, amplify and distribute commercial chickens to end users. The biosecurity and the pathogen fauna of the centers have not been evaluated as to whether the centers could implement the mission effectively without any risk. Thus, the aim of this study was to evaluate the biosecurity practices and the pathogen prevalence, risk factors and their antimicrobial resistance (AMR) using Salmonella as case study...
May 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28520392/gold-nanostar-enhanced-surface-plasmon-resonance-detection-of-an-antibiotic-at-attomolar-concentrations-via-an-aptamer-antibody-sandwich-assay
#6
Suhee Kim, Hye Jin Lee
A new sandwich assay for tetracycline (TC) involving a DNA aptamer and antibody pair is demonstrated in conjunction with gold nanostar (GNS) enhanced surface plasmon resonance (SPR) to achieve detection in the low attomolar range. GNS particles were covalently functionalized with the antibody probe (antiTC) and integrated into a surface sandwich assay in conjunction with a SPR gold chip modified with the TC-specific aptamer. After it was demonstrated that both affinity probes can bind simultaneously to TC, optimization of the assay was performed using either antiTC only or GNS-antiTC conjugates to interact with aptamer/TC complexes present on the chip surface...
May 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28516469/doxycycline-as-an-anti-inflammatory-agent-updates-in-dermatology
#7
REVIEW
M Henehan, M Montuno, A De Benedetto
Doxycycline, a tetracycline antibiotic, is widely used in the field of dermatology for its antibiotic properties, anti-inflammatory properties and good safety profile. Over the past decades, numerous studies have clarified some of the anti-inflammatory mechanisms of doxycycline. In this review article, we aimed to provide an update on recent data on the anti-inflammatory properties of doxycycline and its potential role in cutaneous inflammatory diseases. Better understanding of these mechanisms might offer the practicing clinicians a better use of this therapeutic tool...
May 18, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28516210/antibiotic-resistance-genes-in-surface-water-of-eutrophic-urban-lakes-are-related-to-heavy-metals-antibiotics-lake-morphology-and-anthropic-impact
#8
Yuyi Yang, Chen Xu, Xinhua Cao, Hui Lin, Jun Wang
Urban lakes are impacted by heavy human activities and represent potential reservoirs for antibiotic resistance genes. In this study, six urban lakes in Wuhan, central China were selected to analyze the distribution of sulfonamide resistance (sul) genes, tetracycline resistance (tet) genes and quinolone resistance (qnr) genes and their relationship with heavy metals, antibiotics, lake morphology and anthropic impact. sul1 and sul2 were detected in all six lakes and dominated the types of antibiotic resistance genes, which accounted for 86...
May 17, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28515641/molecular-typing-and-antimicrobial-susceptibility-of-staphylococcus-aureus-strains-isolated-from-raw-milk-cheese-minced-meat-and-chicken-meat-samples
#9
Hayriye Yeşim Can, Mehmet Elmalı, Alper Karagöz
The objectives of this study were: i) to detect the presence of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) in raw milk, cheese, beef minced meat, and chicken meat samples; ii) to evaluate the antimicrobial susceptibility of the isolates; and iii) to determine clonal relation among the isolates by using pulsed-field gel electrophoresis (PFGE) method. Therefore, a total of 160 food samples were randomly collected between August 2014 and May 2015 in Hatay province, located in the southern Turkey...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28515174/functional-assessment-of-sodium-chloride-co-transporter-ncc-mutants-in-polarized-mammalian-epithelial-cells
#10
Lena Lindtoft Rosenbaek, Federica Rizzo, Nanna MacAulay, Olivier Staub, Robert A Fenton
The thiazide-sensitive sodium chloride co-transporter, NCC, is important for maintaining serum sodium (Na+) and, indirectly, serum potassium (K+) levels. Functional studies on NCC have used cell lines with native NCC expression, transiently transfected non-polarized cell lines or Xenopus laevis oocytes. Here, we developed polarized Madin-Darby canine kidney type I (MDCKI) mammalian epithelial cell lines with tetracycline-inducible human NCC expression to study NCC activity and membrane abundance in the same system...
May 17, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28515059/antibiotic-stability-over-six-weeks-in-aqueous-solution-at-body-temperature-with-and-without-heat-treatment-that-mimics-the-curing-of-bone-cement
#11
E Samara, T F Moriarty, L A Decosterd, R G Richards, E Gautier, P Wahl
OBJECTIVES: Thermal stability is a key property in determining the suitability of an antibiotic agent for local application in the treatment of orthopaedic infections. Despite the fact that long-term therapy is a stated goal of novel local delivery carriers, data describing thermal stability over a long period are scarce, and studies that avoid interference from specific carrier materials are absent from the orthopaedic literature. METHODS: In this study, a total of 38 frequently used antibiotic agents were maintained at 37°C in saline solution, and degradation and antibacterial activity assessed over six weeks...
May 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28514013/antimicrobial-prescribing-in-dogs-and-cats-in-australia-results-of-the-australasian-infectious-disease-advisory-panel-survey
#12
L Y Hardefeldt, S Holloway, D J Trott, M Shipstone, V R Barrs, R Malik, M Burrows, S Armstrong, G F Browning, M Stevenson
BACKGROUND: Investigations of antimicrobial use in companion animals are limited. With the growing recognition of the need for improved antimicrobial stewardship, there is urgent need for more detailed understanding of the patterns of antimicrobial use in this sector. OBJECTIVES: To investigate antimicrobial use for medical and surgical conditions in dogs and cats by Australian veterinarians. METHODS: A cross-sectional study was performed over 4 months in 2011...
May 17, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28512600/a-synergistic-effect-of-artocarpanone-from-artocarpus-heterophyllus-l-moraceae-on-the-antibacterial-activity-of-selected-antibiotics-and-cell-membrane-permeability
#13
Abdi Wira Septama, Jianbo Xiao, Pharkphoom Panichayupakaranant
AIM/BACKGROUNDS: Artocarpanone isolated from Artocarpus heterophyllus L. (Moraceae) exhibits antibacterial activity. The present study investigated synergistic activity between artocarpanone and tetracycline, ampicillin, and norfloxacin, respectively, against methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, and Escherichia coli. MATERIALS AND METHODS: A broth microdilution method was used for evaluating antibacterial susceptibility. Synergistic effects were identified using a checkerboard method, and a bacterial cell membrane disruption was investigated by assay of released 260 nm absorbing materials following bacteriolysis...
April 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28512283/unusual-root-canal-irrigation-solutions
#14
Zahed Mohammadi, Hamid Jafarzadeh, Sousan Shalavi, Jun-Ichiro Kinoshita
Microorganisms and their by-products play a critical role in pulp and periradicular pathosis. Therefore, one of the main purposes of root canal treatment is disinfection of the entire system of the canal. This aim may be obtained using mechanical preparation, chemical irrigation, and temporary medication of the canal. For this purpose, various irrigation solutions have been advocated. Common root canal irrigants, such as sodium hypochlorite, chlorhexidine, and a mixture of tetracycline, acid, and detergent have been extensively reviewed...
May 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28511040/removal-of-selected-ppcps-edcs-and-antibiotic-resistance-genes-in-landfill-leachate-by-a-full-scale-constructed-wetlands-system
#15
Xinzhu Yi, Ngoc Han Tran, Tingru Yin, Yiliang He, Karina Yew-Hoong Gin
Landfill leachate could be a significant source of emerging contaminants (ECs) and antibiotic resistance genes (ARGs) into the environment. This study provides the first information on the occurrence of selected ECs and ARGs in raw leachate from 16-year old closed landfill site in Singapore. Among the investigated ECs, acetaminophen (ACT), bisphenol A (BPA), clofibric acid (CA), caffeine (CF), crotamiton (CTMT), diclofenac (DCF), N,N-diethyl-m-toluamide (DEET), gemfibrozil (GFZ), lincomycin (LIN), salicylic acid (SA), and sulfamethazine (SMZ) were the most frequently detected compounds in raw landfill leachate...
May 8, 2017: Water Research
https://www.readbyqxmd.com/read/28510333/tetracycline-inducible-and-reversible-stable-gene-expression-in-human-ipsc-derived-neural-progenitors-and-in-the-postnatal-mouse-brain
#16
Aslam Abbasi Akhtar, Joshua J Breunig
The pB-tet-GOI plasmid system allows for stable piggyBac transposition-mediated integration into cells, a fluorescent nuclear reporter to identify cells that have been transfected, and robust transgene activation or suppression upon the addition of dox to the cell culture or diet of the animal. Furthermore, the addition of luciferase downstream of the target gene allows for quantitative assessment of gene activity in a non-invasive manner. The protocols herein provide instructions for the use of this system in cell lines and in the neonatal mouse brain...
May 16, 2017: Current Protocols in Stem Cell Biology
https://www.readbyqxmd.com/read/28506722/primary-helicobacter-pylori-resistance-in-elderly-patients-over-20-years-a-bulgarian-study
#17
Lyudmila Boyanova, Galina Gergova, Rumyana Markovska, Nayden Kandilarov, Lyubomir Davidkov, Zoya Spassova, Ivan Mitov
We evaluated the antibiotic susceptibility of 233 Helicobacter pylori strains isolated in the period 2011-2016, involving 62 strains from elderly patients aged 66-93years and 171 strains from younger adults. To assess resistance evolution, primary resistance rates in 92 strains from as many patients aged ≥60years in 1996-2003 were compared with those in 85 strains from infected patients in the same age group in 2011-2016. In the patients aged >65years evaluated during the last 6 years, amoxicillin resistance according to EUCAST and prior breakpoints was 1...
May 7, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28505369/identification-of-an-early-male-killing-agent-in-the-oriental-tea-tortrix-homona-magnanima
#18
Yusuke Tsugeno, Hironori Koyama, Takumi Takamatsu, Madoka Nakai, Yasuhisa Kunimi, Maki N Inoue
Arthropods are frequently infected with inherited symbionts, which sometimes confer fitness benefits on female hosts or manipulate host reproduction. Early male killing, in which infected males die during embryogenesis, is induced by some bacteria, such as Wolbachia and Spiroplasma. A female-biased sex ratio has been found in Homona magnanima, collected from a tea plantation in Japan. Here, we examined the male-killing trait in H. magnanima and identified the agent that induces early male killing. The sex-ratio distortion (SR) strain produced only females and no males, and its egg hatch rate was significantly lower than that of the normal (N) strain...
May 15, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28505331/antimicrobial-susceptibility-of-clinical-isolates-of-neisseria-gonorrhoeae-to-alternative-antimicrobials-with-therapeutic-potential
#19
P R S Lagacé-Wiens, H J Adam, N M Laing, M R Baxter, I Martin, M R Mulvey, J A Karlowsky, D J Hoban, G G Zhanel
Background: The prevalence of MDR Neisseria gonorrhoeae is increasing globally and represents a public health emergency. Development and approval of new anti-gonococcal agents may take years. As a concurrent approach to developing new antimicrobials, the laboratory and clinical evaluation of currently licensed antimicrobials not widely used for the treatment of gonorrhoea may provide new options for the treatment of gonococcal infections. Objectives: To determine the in vitro activity of nine alternative, currently licensed and late-development antimicrobials with the potential to treat gonococcal infections against 112 clinical isolates of N...
May 12, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28504897/clonal-complexes-and-antimicrobial-susceptibility-profiles-of-staphylococcus-pseudintermedius-isolates-from-dogs-in-the-united-states
#20
Ricardo Videla, Samar M Solyman, Akshar Brahmbhatt, Leslie Sadeghi, David A Bemis, Stephen A Kania
Staphylococcus pseudintermedius is the primary cause of canine pyoderma and has been associated with diseases in other animals, including human beings. A high prevalence of methicillin and multidrug resistance has been reported in this bacterium in some geographic regions of the United States. Multilocus sequence type (MLST) 68 was implicated, initially, as the major clonal genotype based on a limited number of samples. The objectives of this study were to determine the population genetics of S. pseudintermedius isolated from a cross-section of the United States using a seven-locus multilocus sequence typing method, to identify clonal complexes (CCs), and to correlate sequence types with antimicrobial susceptibility profiles...
May 15, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
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