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https://www.readbyqxmd.com/read/27812018/complete-integrability-of-information-processing-by-biochemical-reactions
#1
Elena Agliari, Adriano Barra, Lorenzo Dello Schiavo, Antonio Moro
Statistical mechanics provides an effective framework to investigate information processing in biochemical reactions. Within such framework far-reaching analogies are established among (anti-) cooperative collective behaviors in chemical kinetics, (anti-)ferromagnetic spin models in statistical mechanics and operational amplifiers/flip-flops in cybernetics. The underlying modeling - based on spin systems - has been proved to be accurate for a wide class of systems matching classical (e.g. Michaelis-Menten, Hill, Adair) scenarios in the infinite-size approximation...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27807271/top-down-models-in-biology-explanation-and-control-of-complex-living-systems-above-the-molecular-level
#2
REVIEW
Giovanni Pezzulo, Michael Levin
It is widely assumed in developmental biology and bioengineering that optimal understanding and control of complex living systems follows from models of molecular events. The success of reductionism has overshadowed attempts at top-down models and control policies in biological systems. However, other fields, including physics, engineering and neuroscience, have successfully used the explanations and models at higher levels of organization, including least-action principles in physics and control-theoretic models in computational neuroscience...
November 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/27708288/cybernetics-a-mathematician-of-mind
#3
Manuel Blum
No abstract text is available yet for this article.
October 5, 2016: Nature
https://www.readbyqxmd.com/read/27624656/the-cybernetics-moment-or-why-we-call-our-age-the-information-age-moore-s-law-the-life-of-gordon-moore-silicon-valley-s-quiet-revolutionary
#4
Jon Agar
No abstract text is available yet for this article.
September 14, 2016: Annals of Science
https://www.readbyqxmd.com/read/27468771/a-review-and-exploration-of-sociotechnical-ergonomics
#5
Riaan Dirkse van Schalkwyk, Rigard J Steenkamp
A holistic review of ergonomic history shows that the science remains important for general occupational health and safety (OSH), the broad society, culture, politics and the design of everyday things. It provides an unconventional and multi- faceted viewpoint exploring ergonomics from a social, corporate and OSH perspective. Ergonomic solutions from this mind-set may re-define the science and it will change with companies that change within this socially hyper-connected world. Authentic corporate social responsibility (CSR) will counter "misleadership" by not approaching ergonomics with an afterthought...
July 28, 2016: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/27375554/calculated-parameters-of-thyroid-homeostasis-emerging-tools-for-differential-diagnosis-and-clinical-research
#6
Johannes W Dietrich, Gabi Landgrafe-Mende, Evelin Wiora, Apostolos Chatzitomaris, Harald H Klein, John E M Midgley, Rudolf Hoermann
Although technical problems of thyroid testing have largely been resolved by modern assay technology, biological variation remains a challenge. This applies to subclinical thyroid disease, non-thyroidal illness syndrome, and those 10% of hypothyroid patients, who report impaired quality of life, despite normal thyrotropin (TSH) concentrations under levothyroxine (L-T4) replacement. Among multiple explanations for this condition, inadequate treatment dosage and monotherapy with L-T4 in subjects with impaired deiodination have received major attention...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27335534/cyborgs-in-the-everyday-masculinity-and-biosensing-prostate-cancer
#7
Gill Haddow, Emma King, Ian Kunkler, Duncan McLaren
An in vivo biosensor is a technology in development that will assess the biological activity of cancers to individualise external beam radiotherapy. Inserting such technology into the human body creates cybernetic organisms; a cyborg that is a human-machine hybrid. There is a gap in knowledge relating to patient willingness to allow automated technology to be embedded and to become cyborg. There is little agreement around what makes a cyborg and less understanding of the variation in the cyborgisation process...
October 2, 2015: Science As Culture
https://www.readbyqxmd.com/read/27314399/evolution-of-microbial-quorum-sensing-to-human-global-quorum-sensing-an-insight-into-how-gap-junctional-intercellular-communication-might-be-linked-to-the-global-metabolic-disease-crisis
#8
James E Trosko
The first anaerobic organism extracted energy for survival and reproduction from its source of nutrients, with the genetic means to ensure protection of its individual genome but also its species survival. While it had a means to communicate with its community via simple secreted molecules ("quorum sensing"), the eventual shift to an aerobic environment led to multi-cellular metazoan organisms, with evolutionary-selected genes to form extracellular matrices, stem cells, stem cell niches, and a family of gap junction or "connexin" genes...
2016: Biology
https://www.readbyqxmd.com/read/27265083/the-dangers-of-cybernetic-medicine-a-dermatologist-s-warning
#9
Mauricio Goihman-Yahr
Confining the actions of physicians to iron-clad directions and blind following of rules and regulations is creating many problems. Not to err does not mean to be right. Overall supervision of medical research and practice is a must for society; yet, minute regulations become a major obstacle for good practice and progress. Medicine is about patients and physicians. Pre-established rules and directives are only tools, not ends in themselves. Societies or institutions that become rigid and inefficient tend to be wiped out when unexpected situations or enemies appear...
May 2016: Clinics in Dermatology
https://www.readbyqxmd.com/read/27118642/navigating-the-affordance-landscape-feedback-control-as-a-process-model-of-behavior-and-cognition
#10
REVIEW
Giovanni Pezzulo, Paul Cisek
We discuss how cybernetic principles of feedback control, used to explain sensorimotor behavior, can be extended to provide a foundation for understanding cognition. In particular, we describe behavior as parallel processes of competition and selection among potential action opportunities ('affordances') expressed at multiple levels of abstraction. Adaptive selection among currently available affordances is biased not only by predictions of their immediate outcomes and payoffs but also by predictions of what new affordances they will make available...
June 2016: Trends in Cognitive Sciences
https://www.readbyqxmd.com/read/27032017/ten-aspects-of-the-big-five-in-the-personality-inventory-for-dsm-5
#11
Colin G DeYoung, Bridget E Carey, Robert F Krueger, Scott R Ross
Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) includes a dimensional model of personality pathology, operationalized in the Personality Inventory for DSM-5 (PID-5), with 25 facets grouped into 5 higher order factors resembling the Big Five personality dimensions. The present study tested how well these 25 facets could be integrated with the 10-factor structure of traits within the Big Five that is operationalized by the Big Five Aspect Scales (BFAS). In 2 healthy adult samples, 10-factor solutions largely confirmed our hypothesis that each of the 10 BFAS would be the highest loading BFAS on 1 and only 1 factor...
April 2016: Personality Disorders
https://www.readbyqxmd.com/read/26982311/epidemiology-of-the-21-st-century-and-cyberspace-rethinking-power-and-the-social-determination-of-health
#12
Jaime Breilh
The study of epidemiologic processes as a form of socially determined movement requires a renewed understanding of the social order, and thus, an updated understanding of the social relations that move society. Recently, the dominance of big corporations on cyberspace has become visible as a new historical process that conditions the social order and extends the technological subordination of daily life, therefore expanding community massive submission to standard conducts. The new digital technological revolution, about which some frightening prognoses are made for the next decades, could easily imply the advent of an era of radical subsumption of life processes...
October 2015: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/26957287/developing-a-complex-systems-perspective-for-medical-education-to-facilitate-the-integration-of-basic-science-and-clinical-medicine
#13
David C Aron
RATIONALE, AIMS AND OBJECTIVES: The purpose of medical education is to produce competent and capable professional practitioners who can combine the art and science of medicine. Moreover, this process must prepare individuals to practise in a field in which knowledge is increasing and the contexts in which that knowledge is applied are changing in unpredictable ways. The 'basic sciences' are important in the training of a physician. The goal of basic science training is to learn it in a way that the material can be applied in practice...
March 8, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/26913617/the-steps-that-can-take-us-miles-examining-the-short-term-dynamics-of-long-term-daily-goal-pursuit
#14
Benjamin M Wilkowski, Elizabeth Louise Ferguson
Cybernetic models suggest that to achieve one's long-term goals, one must create specific plans, enact these plan, monitor progress toward the goal, and resist temptations. Although many studies have examined these proposals in laboratory settings, few studies have examined such processes in daily life. This was the explicit purpose of the current investigation. Participants identified 4 long-term goals during an orientation session. They then completed a diary protocol in which they reported on these self-regulatory processes...
April 2016: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/26908034/vagus-nerve-stimulation-therapy-in-partial-epilepsy-a-review
#15
REVIEW
Mariangela Panebianco, Chiara Zavanone, Sophie Dupont, Domenico A Restivo, Antonino Pavone
Epilepsy is a chronic neurological disorder characterized by recurrent, unprovoked epileptic seizures. The majority of people given a diagnosis of epilepsy have a good prognosis, but 20-30 % will develop drug-resistant epilepsy. Vagus nerve stimulation (VNS) is a neuromodulatory treatment that is used as an adjunctive therapy for treating people with medically refractory epilepsy. It consists of chronic intermittent electrical stimulation of the vagus nerve, delivered by a programmable pulse generator (Neuro-Cybernetic Prosthesis)...
September 2016: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/26841427/learning-linear-representation-of-space-partitioning-trees-based-on-unsupervised-kernel-dimension-reduction
#16
Hongming Shan, Junping Zhang, Uwe Kruger
Space partitioning trees, which sequentially divide and subdivide a space into disjoint subsets using splitting hyperplanes, play a key role in accelerating the query of samples in the cybernetics and computer vision domains. Associated methods, however, suffer from the curse of dimensionality or stringent assumptions on the data distribution. This paper presents a new concept, termed kernel dimension reduction-tree (KDR-tree), that relies on linear projections computed based on an unsupervised kernel dimension reduction approach...
December 24, 2015: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/26837981/efficacy-of-argyrophilic-nucleolar-organizing-region-analysis-using-computer-assisted-and-manual-in-oral-leukoplakia-a-comparative-study
#17
Kavita Nitish Garg, Vineet Raj, Shaleen Chandra
OBJECTIVE: Nucleolar organizer regions are loops of DNA containing ribosomal RNA genes and presumably are associated with ribosomal RNA activity, protein synthesis, and cell proliferation. Argyrophilic nucleolar organizer region (AgNOR) count has been suggested as an objective method in differentiating dysplastic lesions from non-dysplastic lesions. MATERIALS AND METHODS: This descriptive study was done on archival paraffin blocks (n = 60), consisting of 10 normal human oral epithelium, 22 cases of non-dysplastic leukoplakia (NDLK), and 28 cases of dysplastic leukoplakia (DLK)...
January 2015: Indian Journal of Cancer
https://www.readbyqxmd.com/read/26790315/-a-new-strategy-for-chinese-medicine-processing-technologies-coupled-with-individuation-processed-and-cybernetics
#18
Ding-kun Zhang, Ming Yang, Xue Han, Jun-zhi Lin, Jia-bo Wang, Xiao-he Xiao
The stable and controllable quality of decoction pieces is an important factor to ensure the efficacy of clinical medicine. Considering the dilemma that the existing standardization of processing mode cannot effectively eliminate the variability of quality raw ingredients, and ensure the stability between different batches, we first propose a new strategy for Chinese medicine processing technologies that coupled with individuation processed and cybernetics. In order to explain this thinking, an individual study case about different grades aconite is provided...
August 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/26766437/cybernetics-redux-an-outside-in-strategy-for-unraveling-cellular-function
#19
COMMENT
Mohan Malleshaiah, Jeremy Gunawardena
A new paper in Science reveals how repetitive stimulation can identify and help to repair fragilities within a signaling network, while using linear mathematical models inspired by engineering, thereby suggesting how cybernetic methods can be integrated into systems and synthetic biology.
January 11, 2016: Developmental Cell
https://www.readbyqxmd.com/read/26766385/recent-development-in-big-data-analytics-for-business-operations-and-risk-management
#20
Tsan-Ming Choi, Hing Kai Chan, Xiaohang Yue
"Big data" is an emerging topic and has attracted the attention of many researchers and practitioners in industrial systems engineering and cybernetics. Big data analytics would definitely lead to valuable knowledge for many organizations. Business operations and risk management can be a beneficiary as there are many data collection channels in the related industrial systems (e.g., wireless sensor networks, Internet-based systems, etc.). Big data research, however, is still in its infancy. Its focus is rather unclear and related studies are not well amalgamated...
January 12, 2016: IEEE Transactions on Cybernetics
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