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Anthony L Schwartz, Eric Dickerson, Nilesh Dagia, Ramiro Malgor, Kelly D McCall
Heightened co-expression and dysregulated signaling associated with Toll-like receptor 3 (TLR3) and Wnt5a is an integral component of solid tumors and hematological malignancies. Our previous findings in pancreatic cancer and melanoma suggest that inhibition of these pathways by a TLR3 signaling inhibitor, phenylmethimazole (C10), results in significantly decreased IL-6 levels, STAT3 phosphorylation, minimal cancer cell migration and reduced cancer cell growth in vitro and in vivo. In this study, we extended our earlier observations by performing studies in human breast cancer cells...
July 1, 2016: Oncotarget
R D Malgor, G Spentzouris, D Adrahtas, A P Gasparis, A K Tassiopoulos, N Labropoulos
No abstract text is available yet for this article.
January 2013: Journal of Vascular Surgery. Venous and Lymphatic Disorders
Nicos Labropoulos, Rafael D Malgor, Matthew Comito, Antonios P Gasparis, Peter J Pappas, Apostolos K Tassiopoulos
BACKGROUND: Information on ovarian vein thrombosis (OVT) is limited to some retrospective studies. The purpose of this prospective study was to evaluate the natural history and treatment outcomes of OVT. METHODS: Patients with documented symptomatic OVT who were treated with anticoagulation and had at least 3 months of follow-up were included. Outcomes of interest were recanalization rates, pain resolution, pelvic congestion syndrome, recurrent deep venous thrombosis (DVT), and mortality...
January 2015: Journal of Vascular Surgery. Venous and Lymphatic Disorders
R D Malgor, M Comito, A P Gasparis, P Pappas, A K Tassiopoulos, N Labropoulos
No abstract text is available yet for this article.
January 2014: Journal of Vascular Surgery. Venous and Lymphatic Disorders
Rafael D Malgor, Demetri Adrahtas, Georgios Spentzouris, Antonios P Gasparis, Apostolos K Tassiopoulos, Nicos Labropoulos
BACKGROUND: Pelvic congestion syndrome (PCS) imaging workup algorithms are not well-defined. The purpose of our study is to gauge the impact and accuracy of duplex ultrasound (DU) to assist in the diagnosis of PCS. METHODS: We reviewed the records of 48 patients with PCS seen at a vein center from June 2010 to June 2012. All patients had DU plus either computed tomography venography (CTV) or conventional venography (CV). Measurements of the left (LOV) and right ovarian vein (ROV) diameter and the presence or absence of ovarian vein reflux were obtained using DU and compared with either CTV or CV to assess sensitivity and specificity...
January 2014: Journal of Vascular Surgery. Venous and Lymphatic Disorders
Harry Ma, John Blebea, Rafael D Malgor, Kevin E Taubman
BACKGROUND: Compression stockings are commonly prescribed by physicians for lower extremity edema and venous insufficiency. However, no data are available for clinicians to assess the relative quality of various brands, particularly low-cost generics now available directly to consumers through the Internet. We examined the actual compression provided by gradient stockings from multiple manufacturers. METHODS: A total of 36 class 2 (20-30 mm Hg) men's medium-sized below-knee compression stockings from six different manufacturers (n = 6 of each brand) with approximately the same quality and materials were chosen to be studied...
October 2015: Journal of Vascular Surgery. Venous and Lymphatic Disorders
Yuriy Slyvka, Ramiro Malgor, Sharon R Inman, Julia Ding, Victor Heh, Felicia V Nowak
Oxidative stress contributes substantially to the pathophysiology of diabetic nephropathy (DN). Consumption of an antioxidant-fortified (AO) diet from an early age prevents or delays later development of DN in the Zucker rat female with type 2 diabetes. We hypothesize this is due to effects on mesangial matrix and renal nitric oxide synthase (NOS) distribution and to sex-specific differences in NOS responses in the diabetic kidney. Total glomerular tuft area (GTA) and PAS-positive tuft area (PTA), endothelial (e), neuronal (n) and inducible (i) NOS were quantified in males and females on AO or regular (REG) diet at 6 and 20 weeks of age...
March 2016: Acta Histochemica
R D Malgor, Th V Bilfinger, J McCormack, A K Tassiopoulos
BACKGROUND: Blunt thoracic aortic injury (BTAI) is rare and associated with significant morbidity and mortality in trauma patients. As the population ages and life expectancy increases, the frequency of this injury will increase in the elderly and thus it behoves us to understand treatment and outcome in this patient population. METHODS: We analysed prospectively collected data of 10 patients > 80 years old with BTAI (Group A) treated among 26,000 trauma patients over a 20-year period in a Level 1 trauma center to investigate BTAI morbidity and mortality...
May 2015: Acta Chirurgica Belgica
R D Malgor, J S Margolis, J Montecalvo, I Shahidul, G L Hines
OJECTIVES: The purpose of this study was to evaluate the outcomes of endoscopically harvested saphenous vein (EHSV) for lower extremity bypass (LEB) surgery. METHODS: Data from 91 consecutive patients who underwent LEB using EHSV between February 2003 and November 2012 were analyzed. Outcomes of interest were wound infection, patency, re-intervention and limb loss. RESULTS: Fifty-eight (64%) and 33 (36%) patients underwent femoropopliteal (FP) and femorotibial (FT) bypass using EHSV...
September 2014: Acta Chirurgica Belgica
Rafael D Malgor, Peter Gloviczki, Jennifer Fahrni, Manju Kalra, Audra A Duncan, Gustavo S Oderich, Terri Vrtiska, David Driscoll
BACKGROUND: Klippel-Trenaunay syndrome (KTS) is a mixed mesenchymal malformation characterised by varicose veins, venous and capillary malformations, and hypertrophy of soft tissue and bone. The purpose of this study was to evaluate the surgical outcomes in KTS patients to provide standards for comparison with endovenous therapy. METHODS: The clinical data of consecutive patient with KTS who underwent open venous surgical treatment between January 1987 and December 2008 were reviewed...
April 2016: Phlebology
Rafael D Malgor, Fares Alahdab, Fares Alalahdab, Tarig A Elraiyah, Adnan Z Rizvi, Melanie A Lane, Larry J Prokop, Olivia J Phung, Wigdan Farah, Victor M Montori, Michael S Conte, Mohammad Hassan Murad
BACKGROUND: Peripheral arterial disease is common and is associated with significant morbidity and mortality. METHODS: We conducted a systematic review to identify randomized trials and systematic reviews of patients with intermittent claudication to evaluate surgery, endovascular therapy, and exercise therapy. Outcomes of interest were death, amputation, walking distance, quality of life, measures of blood flow, and cost. RESULTS: We included eight systematic reviews and 12 trials enrolling 1548 patients...
March 2015: Journal of Vascular Surgery
Fares Alahdab, Amy T Wang, Tarig A Elraiyah, Rafael D Malgor, Adnan Z Rizvi, Melanie A Lane, Larry J Prokop, Victor M Montori, Michael S Conte, Mohammad Hassan Murad
BACKGROUND: Peripheral arterial disease (PAD) is common and associated with significant morbidity and mortality. PAD can be detected through a noninvasive measurement of the ankle-brachial index (ABI). METHODS: We conducted a systematic review of several electronic bibliographic databases for studies that evaluated ABI as a screening test for PAD in asymptomatic individuals. We conducted random-effects meta-analysis, reporting pooled hazard ratios (HRs) when appropriate...
March 2015: Journal of Vascular Surgery
Rafael D Malgor, Antonios P Gasparis, Nicos Labropoulos
BACKGROUND: The treatment of saphenous vein reflux has evolved over the years with the development of thermal ablation techniques. This study was designed to analyze the complications of endovenous ablation (EVA) using data from an open, voluntary national database. METHODS: We analyzed 349 adverse events of endovenous laser (EVLT) and radiofrequency ablation (RFA) reported in the Manufacturer and User Facility Device Experience (MAUDE) database from January 2000 to June 2012...
February 2016: International Angiology: a Journal of the International Union of Angiology
Aili Guo, Nigel A Daniels, Jean Thuma, Kelly D McCall, Ramiro Malgor, Frank L Schwartz
BACKGROUND: Clinical studies suggest that short-term insulin treatment in new-onset type 2 diabetes (T2DM) can promote prolonged glycemic control. The purpose of this study was to establish an animal model to examine such a "legacy" effect of early insulin therapy (EIT) in long-term glycemic control in new-onset T2DM. The objective of the study was to investigate the role of diet following onset of diabetes in the favorable outcomes of EIT. METHODOLOGY: As such, C57BL6/J male mice were fed a high-fat diet (HFD) for 21 weeks to induce diabetes and then received 4 weeks of daily insulin glargine or sham subcutaneous injections...
2015: PloS One
Pooja M Bhatt, Christopher J Lewis, Denise L House, Chad M Keller, Leonard D Kohn, Mitchell J Silver, Kelly D McCall, Douglas J Goetz, Ramiro Malgor
OBJECTIVE: Wnt5a is a secreted glycoprotein highly present in atherosclerotic lesions. Uptake of oxidized-low density lipoprotein (ox-LDL) by monocytes/macrophages plays a critical role in atherosclerosis. The objective of this study was to determine if Wnt5a mRNA expression correlates with the severity of atherosclerotic lesions, and if, ox-LDL can induce Wnt5a mRNA in macrophages. METHODS: Wnt5a mRNA in tissue sections from carotid arteries of patients undergoing endarterectomy was quantified via RT-PCR and correlated with plaque severity...
2012: Open Circulation & Vascular Journal
Rafael D Malgor, Thomas V Bilfinger, Jane McCormack, Apostolos K Tassiopoulos
BACKGROUND: Blunt traumatic aortic injury (BTAI) is of very rare occurrence in adolescents. The purpose of our study was to assess the clinical presentation and treatment outcomes of BTAI in this subset of patients. METHODS: We reviewed prospective data of 18 patients who were 20 years or younger with BTAI among 28,000 trauma patients from January 1993 to December 2011. Outcomes of interest were the trends on the type of repair (nonoperative [NOP], open repair [OR], or endovascular treatment [ET]) and the impact of concomitant injuries using the Injury Severity Score (ISS) on early morbidity and mortality...
April 2015: Annals of Vascular Surgery
Kelly D McCall, Jean R Thuma, Maria C Courreges, Fabian Benencia, Calvin B L James, Ramiro Malgor, Noriko Kantake, William Mudd, Nathan Denlinger, Bret Nolan, Li Wen, Frank L Schwartz
Group B coxsackieviruses (CVBs) are involved in triggering some cases of type 1 diabetes mellitus (T1DM). However, the molecular mechanism(s) responsible for this remain elusive. Toll-like receptor 3 (TLR3), a receptor that recognizes viral double-stranded RNA, is hypothesized to play a role in virus-induced T1DM, although this hypothesis is yet to be substantiated. The objective of this study was to directly investigate the role of TLR3 in CVB-triggered T1DM in nonobese diabetic (NOD) mice, a mouse model of human T1DM that is widely used to study both spontaneous autoimmune and viral-induced T1DM...
February 2015: Endocrinology
Pooja M Bhatt, Ramiro Malgor
OBJECTIVE: The objective of this article is to review the current literature on Wnt5a and its signaling mechanism, along with its role in atherosclerosis. In addition, the significance of Wnt5a as a diagnostic marker and a potential therapeutic target is reviewed. Wnt5a, a secreted glycoprotein, belongs to a family of highly conserved proteins that regulate important processes such as cell fate specification, embryonic development, cell proliferation, migration, and differentiation in a variety of organisms...
November 2014: Atherosclerosis
Gustavo M S Brandão, Marcone L Sobreira, Rafael D Malgor, Hamilton A Rollo
BACKGROUND: Duplex ultrasound scanning (DUS) is the method of choice for diagnosis of deep vein thrombosis (DVT). However, only a few studies have performed prospective serial DUS after an acute episode of DVT to assess its evolution. This study aimed to report our experience using DUS combined with a thrombosis score (TS) and a newly proposed vein diameter variation index (VDVI) to evaluate the rate of resolution of DVT by assessing and quantifying the early stages of vein recanalization in proximal vein segments within 6 months after an episode of acute lower extremity DVT...
October 2014: Annals of Vascular Surgery
Ramiro Malgor, Pooja M Bhatt, Beth A Connolly, Denise L Jacoby, Kyle J Feldmann, Mitchell J Silver, Masato Nakazawa, Kelly D McCall, Douglas J Goetz
OBJECTIVE AND DESIGN: Atherosclerosis (ATH) is a chronic inflammatory disease that involves cascades of signaling events mediated by various effector proteins. Here we sought to determine if the expression of Wnt5a, a secreted glycoprotein, is altered in discrete regions of the arterial plaque. METHODS: Atherosclerotic plaque tissues from 14 human subjects undergoing elective carotid endarterectomy were used in this study. Immunohistochemistry and laser capture microdissection combined with quantitative real-time PCR were used to determine the expression of Wnt5a and Toll-like receptors (TLRs) in different sections of the arterial lesions...
April 2014: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
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