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Acute bronchiolitis in children

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https://www.readbyqxmd.com/read/29446483/adenovirus-types-associated-with-severe-respiratory-diseases-a-retrospective-four-year-study-in-kuwait
#1
Wassim Chehadeh, Anfal Al-Adwani, Sonia Elezebeth John, Shaikhah Al-Dhufairi, Hessa Al-Dousari, Maha Alkhaledi, Widad Al-Nakib
Human adenovirus (HAdV) infection can result in a severe respiratory disease. The aim of this study was to identify HAdV types detected in patients hospitalized for severe respiratory illness. The study population consisted of 743 patients with severe respiratory disease admitted to four major hospitals in Kuwait between January 2013 and December 2016. Respiratory specimens were retrospectively screened for 20 respiratory viruses by real-time PCR. The HAdV hexon gene was amplified and directly sequenced, and HAdV types were identified by performing Bayesian phylogenetic analysis...
February 15, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29436781/rsv-prophylaxis-guideline-changes-and-outcomes-in-children-with-congenital-heart-disease
#2
Adam S Walpert, Ian D Thomas, Merlin C Lowe, Michael D Seckeler
OBJECTIVE: The aim of this study was to compare inpatient outcomes and costs for children with respiratory syncytial virus and congenital heart disease before and after the change in management guidelines for respiratory syncytial virus prophylaxis. DESIGN: Hospital discharge data from the Vizient (formerly University HealthSystem Consortium) were queried from October 2012 to June 2014 (Era 1) and July 2014 to April 2016 (Era 2) for patients aged <24 months with an any International Classification of Disease (ICD)-9 or ICD-10 code for congenital heart disease (745-747...
February 13, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29424432/human-metapneumovirus-in-hospitalized-children-less-than-five-years-of-age-in-pakistan
#3
Mohammad Tahir Yousafzai, Romesa Ibrahim, Rozina Thobani, Fatima Aziz, Asad Ali
BACKGROUND: Acute respiratory infection (ARI) is the second leading cause of death in children less than five years of age worldwide. Human Metapneumovirus (hMPV) is associated with around 5-7% of the total pneumonia admissions in children. The aim of this study was to determine the magnitude of hMPV associated hospitalizations among children, in Karachi, Pakistan. METHODOLOGY: A three years prospective study was conducted at the Aga Khan University Hospital (AKUH), from August 2009 to June 2012...
February 9, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29402263/effect-of-the-2015-earthquake-on-pediatric-inpatient-pattern-at-a-tertiary-care-hospital-in-nepal
#4
Bishnu Rath Giri, Ram Hari Chapagain, Samana Sharma, Sandeep Shrestha, Sunita Ghimire, P Ravi Shankar
BACKGROUND: Earthquakes impact child health in many ways. Diseases occurring immediately following an earthquake have been studied in field based hospitals but studies on the inpatient disease pattern among children without trauma in a permanent hospital setup is lacking. METHODS: We examined the diagnoses of all children without trauma, admitted to Kanti Children's Hospital, Kathmandu for fifteen-week duration (from 4th week to end of the 18th week) following the 7...
February 5, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29382794/helmet-versus-nasal-prong-cpap-in-infants-with-acute-bronchiolitis
#5
Juan Mayordomo-Colunga, Corsino Rey, Alberto Medina, Pablo Martínez-Camblor, Ana Vivanco-Allende, Andrés Concha
BACKGROUND: Nasal prongs are frequently used to deliver noninvasive CPAP in bronchiolitis, especially in the youngest children. A helmet interface is an alternative that might be comparable to nasal prongs. We sought to compare these interfaces. METHODS: We performed a prospective, randomized, crossover, single-center study in an 8-bed multidisciplinary pediatric ICU in a university hospital. Infants age <3 months who were consecutively admitted to the pediatric ICU during a bronchiolitis epidemic season and fulfilled inclusion criteria were recruited...
January 30, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29380391/rsv-hrv-co-infection-is-a-risk-factor-for-recurrent-bronchial-obstruction-and-early-sensitization-3-years-after-bronchiolitis
#6
F Amat, C Plantard, A Mulliez, I Petit, E Rochette, M Verdan, C Henquell, G Labbé, M C Heraud, B Evrard, A Labbé
OBJECTIVE: To assess risk factors of recurrent bronchial obstruction and allergic sensitization 3 years after an episode of acute bronchiolitis, whether after ambulatory care treatment or hospitalisation. DESIGN: A monocentric prospective longitudinal study including infants aged under 1 year with acute bronchiolitis was performed, with clinical (severity score), biological (serum Krebs von den Lungen 6 antigen), and viral (14 virus by naso-pharyngeal suction detection) assessments...
January 30, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29358416/retrospective-analysis-assessing-the-spatial-and-temporal-distribution-of-paediatric-acute-respiratory-tract-infections-in-ho-chi-minh-city-vietnam
#7
Nhan Thi Ho, Corinne Thompson, Le Nguyen Thanh Nhan, Hoang Minh Tu Van, Nguyen Thanh Dung, Phuc Tran My, Vo Minh Quang, Ngo Ngoc Quang Minh, Tran Anh Tuan, Nguyen Thanh Hung, Ha Manh Tuan, Nguyen Van Vinh Chau, Marcel Wolbers, Guy E Thwaites, Marc Choisy, Stephen Baker
BACKGROUND: Acute respiratory tract infections (ARIs) are the leading cause of morbidity and mortality in young children in low/middle-income countries. Using routine hospital data, we aimed to examine the spatial distribution, temporal trends and climatic risk factors of paediatric ARIs in Vietnam. METHODS: Data from hospitalised paediatric (<16 years) patients with ARIs residing in Ho Chi Minh City (HCMC) between 2005 and 2010 were retrieved from the two main Children's Hospitals and the Hospital for Tropical Diseases in HCMC...
January 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29335081/-expression-of-vascular-intercellular-adhesion-molecule-1-and-its-significance-in-children-with-bronchiolitis
#8
Xiao-Ming Zhang, Hai-Tao Zhu, Ming Chang
OBJECTIVE: To investigate the expression of intercellular adhesion molecule-1 (ICAM-1) in serum and induced sputum supernatant in children with bronchiolitis, as well as its role in the pathogenesis of bronchiolitis in children. METHODS: A total of 67 children with bronchiolitis who were diagnosed and hospitalized between July 2015 and January 2017 were enrolled. According to the diagnostic criteria, these children were divided into mild group with 22 children, moderate group with 24 children, and severe group with 21 children...
January 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29315663/circulating-25-hydroxyvitamin-d-nasopharyngeal-airway-metabolome-and-bronchiolitis-severity
#9
Kohei Hasegawa, Christopher J Stewart, Juan C Celedón, Jonathan M Mansbach, Courtney Tierney, Carlos A Camargo
Low circulating 25-hydroxyvitamin D (25OHD) levels are a risk factor for acute respiratory infection (e.g., bronchiolitis) in children. However, little is known about the relation of circulating 25OHD with the many downstream functional molecules in target organs - such as the airway - and with clinical outcomes. In this prospective multicenter study of infants (age <1 year) hospitalized with bronchiolitis, we measured serum 25OHD levels and profiled the metabolome of 144 nasopharyngeal airway samples. Among 254 metabolites identified, we defined a set of 20 metabolites that are related to lower serum 25OHD and higher vitamin D-binding protein levels...
January 9, 2018: Allergy
https://www.readbyqxmd.com/read/29308548/management-of-recurrent-preschool-doctor-diagnosed-wheeze
#10
REVIEW
Ka-Ka Siu, Shuk-Yu Leung, Sum-Yi Kong, Daniel Kwok-Keung Ng
Preschool wheeze occurs in half of the children before they reach 6 y of age and recurrence is also common. Recurrent preschool wheeze is classified as either typical or atypical. For typical recurrent preschool wheeze, the diagnoses are either asthma or bronchiolitis/bronchitis. Responsiveness to a properly administered bronchodilator confirms asthma, atopic or otherwise. All atypical preschool wheeze should be referred to pediatric respirologist for assessment. Lung function test by impulse oscillometry (IOS) before and after bronchodilator is helpful to confirm airway hyperresponsiveness, an essential feature of asthma...
January 8, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29260375/changing-characteristics-of-hospital-admissions-but-not-the-children-admitted-a-whole-population-study-between-2000-and-2013
#11
Maryam Al-Mahtot, Rebecca Barwise-Munro, Philip Wilson, Steve Turner
There are increasing numbers of emergency medical paediatric admissions. Our hypothesis was that characteristics of children and details of their emergency admissions are also changing over time. Details of emergency admissions in Scotland 2000-2013 were analysed. There were 574,403 emergency admissions, median age 2.3 years. The age distribution, proportion of boys and socioeconomic status of children admitted were essentially unchanged. Emergency admissions rose by 49% from 36/1000 children per annum to 54/1000 between 2000 and 2013...
December 19, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29238000/elevation-of-serum-acid-sphingomyelinase-activity-in-children-with-acute-respiratory-syncytial-virus-bronchiolitis
#12
Shuichiro Yoshida, Atsuko Noguchi, Wataru Kikuchi, Hiroshi Fukaya, Kiyoshi Igarashi, Tsutomu Takahashi
Acid sphingomyelinase (ASM) is a lysosomal enzyme that hydrolyzes sphingomyelin into ceramide, a bioactive lipid to regulate cellular physiological functions. Thus, ASM activation has been reported as a key event in pathophysiological reactions including inflammation, cytokine release, oxidative stress, and endothelial damage in human diseases. Since ASM activation is associated with extracellular ASM secretion through unknown mechanisms, it can be detected by recognizing the elevation of secretory ASM (S-ASM) activity...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29230219/functional-impairment-of-mononuclear-phagocyte-system-by-the-human-respiratory-syncytial-virus
#13
REVIEW
Karen Bohmwald, Janyra A Espinoza, Raúl A Pulgar, Evelyn L Jara, Alexis M Kalergis
The mononuclear phagocyte system (MPS) comprises of monocytes, macrophages (MΦ), and dendritic cells (DCs). MPS is part of the first line of immune defense against a wide range of pathogens, including viruses, such as the human respiratory syncytial virus (hRSV). The hRSV is an enveloped virus that belongs to the Pneumoviridae family, Orthopneumovirus genus. This virus is the main etiological agent causing severe acute lower respiratory tract infection, especially in infants, children and the elderly. Human RSV can cause bronchiolitis and pneumonia and it has also been implicated in the development of recurrent wheezing and asthma...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29227860/respiratory-syncytial-virus-in-brazilian-infants-ten-years-two-cohorts
#14
Elinara Wollmeister, Alfonso Eduardo Alvarez, Juliana Cristina Santiago Bastos, Fernando Augusto Lima Marson, José Dirceu Ribeiro, Emílio Carlos Elias Baracat, Clarice Weis Arns, Adriana Gut Lopes Riccetto
BACKGROUND: Each year, a considerable amount of children will experience at least one episode of acute viral bronchiolitis (AVB) during their first year of life. About 10% of them will be hospitalized, with significant physical and economic burdens. OBJECTIVES: To compare two cohorts of infants with AVB, from same region, in a ten-year interval, regarding epidemiologic factors and viral etiology. STUDY DESIGN: Cohorts: 142 (2004) and 172 (2014) infants at ages zero to 12 months; clinical diagnosis of AVB; medical care in hospital and genetic screening of nasopharyngeal secretion for respiratory viruses...
December 6, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29215378/developing-resident-sensitive-quality-measures-a-model-from-pediatric-emergency-medicine
#15
Daniel J Schumacher, Eric S Holmboe, Cees van der Vleuten, Jamiu O Busari, Carol Carraccio
PURPOSE: To begin closing the gap with respect to quality measures available for use among residents, the authors sought to identify and develop resident-sensitive quality measures (RSQMs) for use in the pediatric emergency department (PED) setting. METHOD: In May 2016, the authors reviewed National Quality Measures Clearinghouse (NQMC) measures to identify resident-sensitive measures. To create additional measures focused on common, acute illnesses (acute asthma exacerbation, bronchiolitis, closed head injury [CHI]) in the PED, the authors used a nominal group technique (NGT) and Delphi process from September to December 2016...
December 5, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29213258/the-complexity-of-antibody-responses-elicited-against-the-respiratory-syncytial-virus-glycoproteins-in-hospitalized-children-younger-than-2-years
#16
Alfonsina Trento, Rosa Rodríguez-Fernández, María I González-Sánchez, Felipe González-Martínez, Vicente Mas, Mónica Vázquez, Concepción Palomo, José A Melero
The influence of age and maternal antibodies on the antibody responses to human respiratory syncytial virus (hRSV) glycoproteins in very young children has been a matter of controversy. Both, immaturity of the immune system at very early age and suppression of the host immune response by high level of maternal antibodies have been claimed to limit the host antibody response to virus infection and to jeopardize the use of hRSV vaccines under development in that age group. Hence, the antibody responses to the two major hRSV glycoproteins (F and G) were evaluated in children younger than 2 years, hospitalized with laboratory confirmed hRSV bronchiolitis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29206851/role-of-viral-coinfections-in-asthma-development
#17
Maria Luz Garcia-Garcia, Cristina Calvo, Sara Ruiz, Francisco Pozo, Victoria Del Pozo, Laura Remedios, Nadia Exposito, Ana Tellez, Inmaculada Casas
BACKGROUND: Viral respiratory infections, especially acute bronchiolitis, play a key role in the development of asthma in childhood. However, most studies have focused on respiratory syncytial virus or rhinovirus infections and none of them have compared the long-term evolution of single versus double or multiple viral infections. OBJECTIVE: Our aim was to compare the frequency of asthma development at 6-8 years in children with previous admission for bronchiolitis associated with single versus double or multiple viral infection...
2017: PloS One
https://www.readbyqxmd.com/read/29193253/clinicians-need-to-decrease-antibiotic-use-in-previously-healthy-infants-hospitalised-with-bronchiolitis
#18
Marion Bailhache, Emilie Bloudeau, Olivier Richer, Pascal Pillet, Marie Lagarde
No abstract text is available yet for this article.
November 28, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29189589/pediatric-emergency-research-canada-origins-and-evolution
#19
Liza Bialy, Amy Plint, Roger Zemek, David Johnson, Terry Klassen, Martin Osmond, Stephen Freedman
OBJECTIVE: The objective of the study was to describe the origins, growth, and progress of a national research network in pediatric emergency medicine. METHODS: The success of Pediatric Emergency Research Canada (PERC) is described in terms of advancing the pediatric emergency medicine agenda, grant funding, peer-reviewed publications, mentoring new investigators, and global collaborations. RESULTS: Since 1995, clinicians and investigators within PERC have grown the network to 15 active tertiary pediatric emergency medicine sites across Canada...
November 20, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29170350/53%C3%A2-piloting-patch-providing-assessment-and-treatment-for-children-at-home-and-piecing-together-what-works
#20
Caroline Ward, Katie Knight, Mary-Rose Ballard, Georgina Keogh, Miriam Samuel, Sara Buttle, Claire Robb, Francesca Cleugh
AIMS: PATCH is a pilot acute community children's nurse led service delivering assessment and treatment for children at home who are moderately unwell and might otherwise be admitted to hospital or attend Paediatric Emergency Department (PED). Children are referred by PED or GP and followed up via telephone support and home visits depending on clinical need for duration of acute illness. METHODS: Pilot year funded by Imperial Charity. Using evaluation to build business case for sustained commissioned service...
December 2017: Emergency Medicine Journal: EMJ
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