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Acute bronchiolitis in children

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https://www.readbyqxmd.com/read/29692622/identifying-agents-triggering-bronchiolitis-in-the-state-of-qatar
#1
Mohamed A Hendaus, Ahmed H Alhammadi, Prem Chandra, Eshan Muneer, Mohamed S Khalifa
Background: Bronchiolitis is considered as the most frequent lower respiratory tract infection in infants and young children. This disorder is marked by acute inflammation, edema, damage of epithelial cells lining small airways, and augmentation of mucus production. Objective: The goal of the study was to identify agents triggering bronchiolitis in the State of Qatar. Materials and methods: A cross-sectional retrospective study was performed at Hamad Medical Corporation, the only tertiary and academic medical center in the State of Qatar...
2018: International Journal of General Medicine
https://www.readbyqxmd.com/read/29677180/do-inhaled-corticosteroids-have-a-role-for-bronchiolitis
#2
Gonzalo Alarcón-Andrade, Lorena Cifuentes
INTRODUCTION: Bronchiolitis consists of an acute small airways inflammation secondary to a viral infection and is a frequent pathology among children under 2 years. The use of inhaled corticosteroids during bronchiolitis has been proposed to reduce recurrent wheeze or asthma, however there is controversy about it. METHODS: To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others...
April 17, 2018: Medwave
https://www.readbyqxmd.com/read/29666383/effect-of-antibiotic-use-for-acute-bronchiolitis-on-new-onset-asthma-in-children
#3
I-Lun Chen, Hsin-Chun Huang, Yu-Han Chang, Hsin-Yi Huang, Wei-Ju Yeh, Ting-Yi Wu, Jau-Ling Suen, San-Nan Yang, Chih-Hsing Hung
Early-life use of antibiotics is associated with asthma. We examined the effect of antibiotic use for early-life bronchiolitis on the development of new-onset asthma in children from Taiwan between 2005 and 2010. Data were from the National Health Insurance Research Database 2010, and diseases were coded using the International Classification of Disease (ICD). We classified the patients, all of whom had bronchiolitis, as having asthma or not having asthma. Asthma was diagnosed using ICD criteria and by use of an inhaled bronchodilator and/or corticosteroid twice in one year...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29580908/-extracorporeal-life-support-and-heart-lung-transplant-in-children
#4
Sébastien Hascoet, Angèle Boet, Karine Nubret, Marc Lilot, Séverine Feuillet, Nadir Benbrik, Julien Guihaire, Emmanuel Le Bret, Elie Fadel, Virginie Fouilloux, Pascal Amedro, Lucile Houyel, Bernard Kreitmann
Extracorporeal life support and heart and/or lung transplant are the last resort in children with end-stage cardiac and/or pulmonary failure and short-term life threaten. Currently, circulatory support is used as a bridge to recovery or as a bridge to transplant but not as a destination therapy. The Excor Berlin Heart is the long-lasting external pneumatic ventricular assist system that is currently available from infancy to adulthood. Long-term prognosis after pediatric cardiac and/or pulmonary transplant is conditioned by the occurrence of graft failure, coronary disease of the cardiac graft, viral infections and bronchiolitis obliterans of the pulmonary graft, the incidence of which increase with time...
March 23, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29575773/non-invasive-ventilation-practices-in-children-across-europe
#5
Juan Mayordomo-Colunga, Martí Pons-Òdena, Alberto Medina, Corsino Rey, Christophe Milesi, Merja Kallio, Andrea Wolfler, Mireia García-Cuscó, Demet Demirkol, Milagros García-López, Peter Rimensberger
OBJECTIVES: To describe the diversity in practice in non-invasive ventilation (NIV) in European pediatric intensive care units (PICUs). WORKING HYPOTHESIS: No information about the use of NIV in Pediatrics across Europe is currently available, and there might be a wide variability regarding the approach. STUDY DESIGN: Cross-sectional electronic survey. METHODOLOGY: The survey was distributed to the ESPNIC mailing list and to researchers in different European centers...
March 24, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29562753/nucleosides-for-the-treatment-of-respiratory-rna-virus-infections
#6
Paul C Jordan, Sarah K Stevens, Jerome Deval
Influenza virus, respiratory syncytial virus, human metapneumovirus, parainfluenza virus, coronaviruses, and rhinoviruses are among the most common viruses causing mild seasonal colds. These RNA viruses can also cause lower respiratory tract infections leading to bronchiolitis and pneumonia. Young children, the elderly, and patients with compromised cardiac, pulmonary, or immune systems are at greatest risk for serious disease associated with these RNA virus respiratory infections. In addition, swine and avian influenza viruses, together with severe acute respiratory syndrome-associated and Middle Eastern respiratory syndrome coronaviruses, represent significant pandemic threats to the general population...
January 2018: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/29528202/early-predictors-of-unresponsiveness-to-high-flow-nasal-cannula-therapy-in-a-pediatric-emergency-department
#7
Anıl Er, Aykut Çağlar, Fatma Akgül, Emel Ulusoy, Hale Çitlenbik, Durgül Yılmaz, Murat Duman
AIM: High-flow nasal cannula (HFNC) is a new treatment option for pediatric respiratory distress and we aimed to assess early predictive factors of unresponsiveness to HFNC therapy in a pediatric emergency department (ED). METHOD: Patients who presented with respiratory distress and were treated by HFNC, were included. The age, gender, weight, medical history, diagnosis, vital signs, oxygen saturation/fraction of inspired oxygen (SpO2 /FiO2 ) ratio, modified Respiratory Distress Assessment Instrument (mRDAI) scores, medical interventions, duration of HFNC therapy, time to escalation, adverse effects, and laboratory test results were obtained from medical and nursing records...
March 12, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29485692/cd64-on-monocytes-and-granulocytes-in-severe-acute-bronchiolitis-pilot-study-on-its-usefulness-as-a-bacterial-infection-biomarker
#8
Alberto García-Salido, Ana Serrano-González, Juan Casado-Flores, Montserrat Sierra-Colomina, Amelia Martínez de Azagra-Garde, María Ángeles García-Teresa, Gustavo J Melen, Manuel Ramírez-Orellana
The CD64 receptor has been described as a biomarker of bacterial infection. We speculated that CD64 surface expression on monocytes and granulocytes of children with severe acute bronchiolitis (SAB) could be altered in cases of probable bacterial infection (PBI) determined using classical biomarkers (procalcitonin and C-reactive protein, leukocyte count, and radiographic findings). A prospective observational pilot study was conducted from October 2015 to February 2016 in children admitted for pediatric critical care...
February 27, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29446483/adenovirus-types-associated-with-severe-respiratory-diseases-a-retrospective-four-year-study-in-kuwait
#9
Wassim Chehadeh, Anfal Al-Adwani, Sonia Elezebeth John, Shaikhah Al-Dhufairi, Hessa Al-Dousari, Maha Alkhaledi, Widad Al-Nakib
Human adenovirus (HAdV) infection can result in a severe respiratory disease. The aim of this study was to identify HAdV types detected in patients hospitalized for severe respiratory illness. The study population consisted of 743 patients with severe respiratory disease admitted to four major hospitals in Kuwait between January 2013 and December 2016. Respiratory specimens were retrospectively screened for 20 respiratory viruses by real-time PCR. The HAdV hexon gene was amplified and directly sequenced, and HAdV types were identified by performing Bayesian phylogenetic analysis...
February 15, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29436781/rsv-prophylaxis-guideline-changes-and-outcomes-in-children-with-congenital-heart-disease
#10
Adam S Walpert, Ian D Thomas, Merlin C Lowe, Michael D Seckeler
OBJECTIVE: The aim of this study was to compare inpatient outcomes and costs for children with respiratory syncytial virus and congenital heart disease before and after the change in management guidelines for respiratory syncytial virus prophylaxis. DESIGN: Hospital discharge data from the Vizient (formerly University HealthSystem Consortium) were queried from October 2012 to June 2014 (Era 1) and July 2014 to April 2016 (Era 2) for patients aged <24 months with an any International Classification of Disease (ICD)-9 or ICD-10 code for congenital heart disease (745-747...
February 13, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29424432/human-metapneumovirus-in-hospitalized-children-less-than-five-years-of-age-in-pakistan
#11
Mohammad Tahir Yousafzai, Romesa Ibrahim, Rozina Thobani, Fatima Aziz, Asad Ali
BACKGROUND: Acute respiratory infection (ARI) is the second leading cause of death in children less than five years of age worldwide. Human Metapneumovirus (hMPV) is associated with around 5-7% of the total pneumonia admissions in children. The aim of this study was to determine the magnitude of hMPV associated hospitalizations among children, in Karachi, Pakistan. METHODOLOGY: A three years prospective study was conducted at the Aga Khan University Hospital (AKUH), from August 2009 to June 2012...
February 9, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29402263/effect-of-the-2015-earthquake-on-pediatric-inpatient-pattern-at-a-tertiary-care-hospital-in-nepal
#12
Bishnu Rath Giri, Ram Hari Chapagain, Samana Sharma, Sandeep Shrestha, Sunita Ghimire, P Ravi Shankar
BACKGROUND: Earthquakes impact child health in many ways. Diseases occurring immediately following an earthquake have been studied in field based hospitals but studies on the inpatient disease pattern among children without trauma in a permanent hospital setup is lacking. METHODS: We examined the diagnoses of all children without trauma, admitted to Kanti Children's Hospital, Kathmandu for fifteen-week duration (from 4th week to end of the 18th week) following the 7...
February 5, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29382794/helmet-versus-nasal-prong-cpap-in-infants-with-acute-bronchiolitis
#13
Juan Mayordomo-Colunga, Corsino Rey, Alberto Medina, Pablo Martínez-Camblor, Ana Vivanco-Allende, Andrés Concha
BACKGROUND: Nasal prongs are frequently used to deliver noninvasive CPAP in bronchiolitis, especially in the youngest children. A helmet interface is an alternative that might be comparable to nasal prongs. We sought to compare these interfaces. METHODS: We performed a prospective, randomized, crossover, single-center study in an 8-bed multidisciplinary pediatric ICU in a university hospital. Infants age <3 months who were consecutively admitted to the pediatric ICU during a bronchiolitis epidemic season and fulfilled inclusion criteria were recruited...
April 2018: Respiratory Care
https://www.readbyqxmd.com/read/29380391/rsv-hrv-co-infection-is-a-risk-factor-for-recurrent-bronchial-obstruction-and-early-sensitization-3-years-after-bronchiolitis
#14
Flore Amat, Chloé Plantard, Aurélien Mulliez, Isabelle Petit, Emmanuelle Rochette, Matthieu Verdan, Cécile Henquell, Guillaume Labbé, Marie Christine Heraud, Bertrand Evrard, André Labbé
To assess risk factors of recurrent bronchial obstruction and allergic sensitization 3 years after an episode of acute bronchiolitis, whether after ambulatory care treatment or hospitalization. A monocentric prospective longitudinal study including infants aged under 1 year with acute bronchiolitis was performed, with clinical (severity score), biological (serum Krebs von den Lungen 6 antigen), and viral (14 virus by naso-pharyngeal suction detection) assessments. Follow-up included a quaterly telephone interview, and a final clinical examination at 3 years...
May 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29358416/retrospective-analysis-assessing-the-spatial-and-temporal-distribution-of-paediatric-acute-respiratory-tract-infections-in-ho-chi-minh-city-vietnam
#15
Nhan Thi Ho, Corinne Thompson, Le Nguyen Thanh Nhan, Hoang Minh Tu Van, Nguyen Thanh Dung, Phuc Tran My, Vo Minh Quang, Ngo Ngoc Quang Minh, Tran Anh Tuan, Nguyen Thanh Hung, Ha Manh Tuan, Nguyen Van Vinh Chau, Marcel Wolbers, Guy E Thwaites, Marc Choisy, Stephen Baker
BACKGROUND: Acute respiratory tract infections (ARIs) are the leading cause of morbidity and mortality in young children in low/middle-income countries. Using routine hospital data, we aimed to examine the spatial distribution, temporal trends and climatic risk factors of paediatric ARIs in Vietnam. METHODS: Data from hospitalised paediatric (<16 years) patients with ARIs residing in Ho Chi Minh City (HCMC) between 2005 and 2010 were retrieved from the two main Children's Hospitals and the Hospital for Tropical Diseases in HCMC...
January 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29335081/-expression-of-vascular-intercellular-adhesion-molecule-1-and-its-significance-in-children-with-bronchiolitis
#16
Xiao-Ming Zhang, Hai-Tao Zhu, Ming Chang
OBJECTIVE: To investigate the expression of intercellular adhesion molecule-1 (ICAM-1) in serum and induced sputum supernatant in children with bronchiolitis, as well as its role in the pathogenesis of bronchiolitis in children. METHODS: A total of 67 children with bronchiolitis who were diagnosed and hospitalized between July 2015 and January 2017 were enrolled. According to the diagnostic criteria, these children were divided into mild group with 22 children, moderate group with 24 children, and severe group with 21 children...
January 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29315663/circulating-25-hydroxyvitamin-d-nasopharyngeal-airway-metabolome-and-bronchiolitis-severity
#17
K Hasegawa, C J Stewart, J C Celedón, J M Mansbach, C Tierney, C A Camargo
Low circulating 25-hydroxyvitamin D (25OHD) levels are a risk factor for acute respiratory infection (eg, bronchiolitis) in children. However, little is known about the relation of circulating 25OHD with the many downstream functional molecules in target organs-such as the airway-and with clinical outcomes. In this prospective multicenter study of infants (age <1 year) hospitalized with bronchiolitis, we measured serum 25OHD levels and profiled the metabolome of 144 nasopharyngeal airway samples. Among 254 metabolites identified, we defined a set of 20 metabolites that are related to lower serum 25OHD and higher vitamin D-binding protein levels...
January 9, 2018: Allergy
https://www.readbyqxmd.com/read/29308548/management-of-recurrent-preschool-doctor-diagnosed-wheeze
#18
REVIEW
Ka-Ka Siu, Shuk-Yu Leung, Sum-Yi Kong, Daniel Kwok-Keung Ng
Preschool wheeze occurs in half of the children before they reach 6 y of age and recurrence is also common. Recurrent preschool wheeze is classified as either typical or atypical. For typical recurrent preschool wheeze, the diagnoses are either asthma or bronchiolitis/bronchitis. Responsiveness to a properly administered bronchodilator confirms asthma, atopic or otherwise. All atypical preschool wheeze should be referred to pediatric respirologist for assessment. Lung function test by impulse oscillometry (IOS) before and after bronchodilator is helpful to confirm airway hyperresponsiveness, an essential feature of asthma...
January 8, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29260375/changing-characteristics-of-hospital-admissions-but-not-the-children-admitted-a-whole-population-study-between-2000-and-2013
#19
Maryam Al-Mahtot, Rebecca Barwise-Munro, Philip Wilson, Steve Turner
There are increasing numbers of emergency medical paediatric admissions. Our hypothesis was that characteristics of children and details of their emergency admissions are also changing over time. Details of emergency admissions in Scotland 2000-2013 were analysed. There were 574,403 emergency admissions, median age 2.3 years. The age distribution, proportion of boys and socioeconomic status of children admitted were essentially unchanged. Emergency admissions rose by 49% from 36/1000 children per annum to 54/1000 between 2000 and 2013...
March 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29238000/elevation-of-serum-acid-sphingomyelinase-activity-in-children-with-acute-respiratory-syncytial-virus-bronchiolitis
#20
Shuichiro Yoshida, Atsuko Noguchi, Wataru Kikuchi, Hiroshi Fukaya, Kiyoshi Igarashi, Tsutomu Takahashi
Acid sphingomyelinase (ASM) is a lysosomal enzyme that hydrolyzes sphingomyelin into ceramide, a bioactive lipid to regulate cellular physiological functions. Thus, ASM activation has been reported as a key event in pathophysiological reactions including inflammation, cytokine release, oxidative stress, and endothelial damage in human diseases. Since ASM activation is associated with extracellular ASM secretion through unknown mechanisms, it can be detected by recognizing the elevation of secretory ASM (S-ASM) activity...
December 2017: Tohoku Journal of Experimental Medicine
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