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https://www.readbyqxmd.com/read/29123127/a-mechanism-for-ftsz-independent-proliferation-in-streptomyces
#1
Fernando Santos-Beneit, David M Roberts, Stuart Cantlay, Joseph R McCormick, Jeff Errington
The central player in bacterial cell division, FtsZ, is essential in almost all organisms in which it has been tested, with the most notable exception being Streptomyces. Streptomycetes differ from many bacteria in growing from the cell tip and undergoing branching, similar to filamentous fungi. Here we show that limited cell damage, either mechanical or enzymatic, leads to near complete destruction of mycelial microcolonies of a Streptomyces venezuelae ftsZ mutant. This result is consistent with a lack of ftsZ-dependent cross-walls and may be inconsistent with a recently proposed role for membrane structures in the proliferation of ftsZ mutants in other Streptomyces species...
November 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/29114342/guyana-s-paediatric-training-program-a-global-health-partnership-for-medical-education
#2
Lita Cameron, Julie C Johnstone, Arnelle Sparman, Leif D Nelin, Narendra C Singh, Andrea Hunter
Guyana is a low-middle income country on the northern coast of South America between Venezuela and Suriname. Guyana has relatively high child mortality and a notable gap in health care provision. As of 2011, there were no paediatricians in the public sector where approximately 90% of the population seek care. In response to this unmet need, Guyanese diaspora living in Canada, in partnership with Canadian paediatricians and the main teaching hospital, Georgetown Public Hospital Corporation (GPHC), developed a Master's program in paediatrics...
April 2017: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/29110845/an-international-epidemiological-analysis-of-young-patients-with-non-small-cell-lung-cancer-adujov-clicap
#3
Luis Corrales-Rodríguez, Oscar Arrieta, Luis Mas, Renata Báez-Saldaña, Omar Castillo-Fernández, Normand Blais, Claudio Martín, Melissa Juárez, Priyanka Khanna, Allan Ramos-Esquivel, Ludwing Bacon, Leonardo Rojas, Beatriz Wills, George Oblitas, María Angelina Pérez, Mauricio Cuello, Andrés Felipe Cardona
BACKGROUND: A proportion of patients with NSCLC is diagnosed at 40 years or younger. These patients tend to be never-smokers, usually present with stage IV adenocarcinoma, and have somatic genomic alterations. Few studies have documented and analyzed epidemiological characteristics of this population. MATERIALS AND METHODS: We performed an international epidemiological analysis of 389 young patients with NSCLC. Data was collected from centers participating in the Latin American Consortium for Lung Cancer Research (AduJov-CLICaP)...
November 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29107512/american-strain-of-zika-virus-causes-more-severe-microcephaly-than-an-old-asian-strain-in-neonatal-mice
#4
Feng Zhang, Hong-Jiang Wang, Qin Wang, Zhong-Yu Liu, Ling Yuan, Xing-Yao Huang, Guanghui Li, Qing Ye, Haozhen Yang, Lei Shi, Yong-Qiang Deng, Cheng-Feng Qin, Zhiheng Xu
Zika virus (ZIKV) has evolved from an overlooked mosquito-borne flavivirus into a global health threat due to its astonishing causal link to microcephaly and other disorders. ZIKV has been shown to infect neuronal progenitor cells of the fetal mouse brain, which is comparable to the first-trimester human fetal brain, and result in microcephaly. However, whether there are different effects between the contemporary ZIKV strain and its ancestral strain in the neonatal mouse brain, which is comparable with the second-trimester human fetal brain, is unclear...
October 20, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29106817/application-of-the-aace-ace-advanced-framework-for-the-diagnosis-of-obesity-and-cardiometabolic-disease-staging-in-a-general-population-from-three-regions-of-venezuela-the-vemsols-study-results
#5
Ramfis Nieto-Martínez, Juan P González-Rivas, Eunice Ugel, Imperia Brajkovich, Alejandro Risquez, W Timothy Garvey, Jeffrey I Mechanick
OBJECTIVE: To determine the prevalence of obesity according to the AACE/ACE framework based on a complications-centric model with further application of the Cardiometabolic Disease Staging (CMDS) system in Venezuelan population. METHODS: 1,320 adults were randomly selected from 3 regions. AACE/ACE framework definitions: overweight: body mass index (BMI) 25 to 29.9 kg/m(2) and no obesity-related complications (ORC); obesity stage 0: BMI ≥ 30 and no ORC; stage 1: BMI ≥ 25 and one or more mild-to-moderate ORC; and stage 2: BMI ≥ 25 and one or more severe ORC...
November 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29099150/expanded-carrier-screening-in-gamete-donors-of-venezuela
#6
Maria Teresa Urbina, Isaac Benjamin, Randolfo Medina, José Jiménez, Laura Trías, Jorge Lerner
OBJECTIVE: To discuss the implications of expanded genetic carrier screening for preconception purposes based on our practice. METHODS: One hundred and forty-three potential gamete donors aged 20-32 years old (µ=24, 127 females and 16 males), signed informed consent forms and were selected according to the REDLARA guidelines. Blood or saliva samples were examined by one of these genetic carrier screening methods: Genzyme screening for Cystic Fibrosis (CF), Fragile X and Spinal Muscular Atrophy (SMA); Counsyl Universal panel or Recombine Carrier Map...
November 3, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29091170/-seroprevalence-of-trypanosoma-cruzi-infection-in-the-rural-population-of-sucre-state-venezuela
#7
Noris García-Jordán, Mariolga Berrizbeitia, Jessicca Rodríguez, Juan Luis Concepción, Ana Cáceres, Wilfredo Quiñones
The current study aimed to determine the seroprevalence of Trypanosoma cruzi infection in Sucre State, Venezuela, and its association with epidemiological risk factors. The cluster sampling design allowed selecting 96 villages and 576 dwellings in the State's 15 municipalities. A total of 2,212 serum samples were analyzed by ELISA, HAI, and IFI. Seroprevalence in Sucre State was 3.12%. Risk factors associated with T. cruzi infection were: accumulated garbage, flooring and wall materials, type of dwelling, living in a house with wattle and daub walls and/or straw roofing, living in a house with risky walls and roofing, risky buildings and wattle and daub outbuildings, poultry inside the human dwelling, and presence of firewood...
October 26, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29058148/complete-genome-sequence-of-two-tomato-infecting-begomoviruses-in-venezuela-evidence-of-a-putative-novel-species-and-a-novel-recombinant-strain
#8
Gustavo Romay, Dorys T Chirinos, Francis Geraud-Pouey, Annika Gillis, Jacques Mahillon, Claude Bragard
At least six begomovirus species have been reported infecting tomato in Venezuela. In this study the complete genomes of two tomato-infecting begomovirus isolates (referred to as Trujillo-427 and Zulia-1084) were cloned and sequenced. Both isolates showed the typical genome organization of New World bipartite begomoviruses, with DNA-A genomic components displaying 88.8% and 90.3% similarity with established begomoviruses, for isolates Trujillo-427 and Zulia-1084, respectively. In accordance to the guidelines for begomovirus species demarcation, the Trujillo-427 isolate represents a putative new species and the name "Tomato wrinkled mosaic virus" is proposed...
October 20, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29028314/heterologous-gene-expression-of-n-terminally-truncated-variants-of-lippks1-suggests-a-functionally-critical-structural-motif-in-the-n-terminus-of-modular-polyketide-synthase
#9
Satoshi Yuzawa, Constance B Bailey, Tatsuya Fujii, Renee Jocic, Jesus F Barajas, Veronica T Benites, Edward E K Baidoo, Yan Chen, Christopher J Petzold, Leonard Katz, Jay D Keasling
Streptomyces genomes have a high G + C content and typically use an ATG or GTG codon to initiate protein synthesis. Although gene-finding tools perform well in low GC genomes, it is known that the accuracy in predicting a translational start site (TSS) is much less for high GC genomes. LipPks1 is a Streptomyces-derived, well-characterized modular polyketide synthase (PKS). Using this enzyme as a model, we experimentally investigated the effects of alternative TSSs using a heterologous host, Streptomyces venezuelae...
October 17, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29028167/progress-towards-eliminating-onchocerciasis-in-the-who-region-of-the-americas-elimination-of-transmission-in-the-north-east-focus-of-the-bolivarian-republic-of-venezuela
#10
(no author information available yet)
No abstract text is available yet for this article.
October 13, 2017: Relevé épidémiologique Hebdomadaire
https://www.readbyqxmd.com/read/29016315/case-report-molecular-confirmation-of-lobomycosis-in-an-italian-traveler-acquired-in-the-amazon-region-of-venezuela
#11
Anna Beltrame, Patrizia Danesi, Claudio Farina, Pierantonio Orza, Francesca Perandin, Claudia Zanardello, Paola Rodari, Silvia Staffolani, Zeno Bisoffi
Lobomycosis is a chronic skin mycosis endemic in Amazon regions characterized by chronic nodular or keloidal lesions caused by Lacazia loboi, an uncultivable fungus. Imported cases in nonendemic countries are rare and diagnosed after years. We describe a case of lobomycosis in a healthy 55-year-old Italian traveler who had acquired the infection during 5-day-honeymoon in the Amazon region of Venezuela in 1999. Several weeks after return, he recalled pruritus and papular skin lesions on the left lower limb, subsequently evolving to a plaque-like lesion...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28985329/self-rated-health-and-its-association-with-mortality-in-older-adults-in-china-india-and-latin-america-a-10-66-dementia-research-group-study
#12
Hanna Falk, Ingmar Skoog, Lena Johansson, Maëlenn Guerchet, Rosie Mayston, Helena Hörder, Martin Prince, A Matthew Prina
Background: empirical evidence from high-income countries suggests that self-rated health (SRH) is useful as a brief and simple outcome measure in public health research. However, in many low- and middle-income countries (LMIC) there is a lack of evaluation and the cross-cultural validity of SRH remains largely untested. This study aims to explore the prevalence of SRH and its association with mortality in older adults in LMIC in order to cross-culturally validate the construct of SRH...
November 1, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28974279/multilocus-phylogenetic-analysis-and-morphological-data-reveal-a-new-species-composition-of-the-genus-drepanocephalus-dietz-1909-digenea-echinostomatidae-parasites-of-fish-eating-birds-in-the-americas
#13
E Hernández-Cruz, J S Hernández-Orts, A L Sereno-Uribe, G Pérez-Ponce de León, M García-Varela
Members of the genus Drepanocephalus are endoparasites of fish-eating birds of the families Phalacrocoracidae and Sulidae distributed across the Americas. Currently, Drepanocephalus contains three species, i.e. D. spathans (type species), D. olivaceus and D. auritus. Two additional species, D. parvicephalus and D. mexicanus were transferred to the genus Petasiger. In the current study, available DNA sequences of D. spathans, D. auritus and Drepanocephalus sp., were aligned with newly generated sequences of D...
October 4, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28962581/large-country-differences-in-work-outcomes-in-patients-with-ra-an-analysis-in-the-multinational-study-comora
#14
Antje van der Zee-Neuen, Polina Putrik, Sofia Ramiro, Andras P Keszei, Ihsane Hmamouchi, Maxime Dougados, Annelies Boonen
BACKGROUND: We aimed to explore whether country of residence or specific country characteristics are associated with work outcomes in rheumatoid arthritis (RA). METHODS: Data from the 17 countries participating in the Comorbidities in RA (COMORA) study were used. Work outcomes were measured by the Work Productivity and Activity Impairment Questionnaire, addressing employment (yes/no), absenteeism (percentage of time; 3 categories) and presenteeism (percentage of at-work productivity restrictions; 4 categories)...
September 29, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28956541/spatial-distribution-of-zika-virus-infection-in-northeastern-colombia
#15
Alfonso J Rodriguez-Morales, Ubydul Haque, Jacob Ball, Carlos Julian García-Loaiza, Maria Leonor Galindo-Marquez, Juan Alejandro Sabogal-Roman, Santiago Marin-Loaiza, Andrés Felipe Ayala, Carlos O Lozada-Riascos, Fredi A Diaz-Quijano, Jorge L Alvarado-Socarras
In this study, we investigated the weekly reported spatio-temporal distribution and topographic risk factors for Zika virus (ZIKV) infection in northeastern Colombia. Weekly reported surveillance data, including clinical, suspected and confirmed cases from the ongoing ZIKV epidemic in the Santander and Norte de Santander departments (Santanderes) in Colombia were used to estimate cumulative incidence rates. Spatial analysis was performed to develop hot spot maps and to identify spatial topographic risk factors for infection...
September 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28947706/gba-mutations-in-gaucher-type-i-venezuelan-patients-ethnic-origins-and-frequencies
#16
Gilberto Gómez, Sergio Arias, Leonor Cárdenas, Dalal Zoghbi, Irene Paradisi
Gaucher disease (GD), the most frequent lysosomal storage disease, is caused by heterogeneous mutations in the locus coding for glucocerebrosidase (GBA). It is an autosomal recessive disorder with different phenotypes of which the most frequent is the nonneuronopathic or type 1, prevalent worldwide. To date, more than 430 mutations have been described, but their frequency distribution varies in different populations with four, N370S, L444P, IVS2 + 1G > A and 84insG, being the most frequent ones. In Venezuela, 20 unrelated index cases with GD type I were assessed for GBA mutation detection and for their in-phase haplotype identification, to gather genetic epidemiological data on the disease in the country and of its eventual ethnic origin...
September 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28935118/ex-vivo-trypanocidal-activity-of-1-2-hydroxybenzylidene-thiosemicarbazide-against-trypanosoma-equiperdum
#17
N Parra, M Jaume, K Boscán, A Hernández, A Mijares, M González, Y Alvarado, J Restrepo
Trypanosoma equiperdum is the causative agent of dourine, a venereal disease in horses and donkeys. This parasite has a widely distribution, is found in Africa, Asia, Southern and Eastern Europe, Russia, Mexico and Venezuela. The T. equiperdum is morphologically indistinguishable to other Trypanozoon species, however differs from other mammalian trypanosomes due to the fact that it is primarily a tissue parasite, generating cutaneous plaques, swelling of genitalia and neurological signs. The aim of this study was to evaluate the trypanocidal effectiveness of a set of derivatives of thiosemicarbazones on a T...
July 8, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28934499/co-produced-natural-ketolides-methymycin-and-pikromycin-inhibit-bacterial-growth-by-preventing-synthesis-of-a-limited-number-of-proteins
#18
Mashal M Almutairi, Maxim S Svetlov, Douglas A Hansen, Nelli F Khabibullina, Dorota Klepacki, Han-Young Kang, David H Sherman, Nora Vázquez-Laslop, Yury S Polikanov, Alexander S Mankin
Antibiotics methymycin (MTM) and pikromycin (PKM), co-produced by Streptomyces venezuelae, represent minimalist macrolide protein synthesis inhibitors. Unlike other macrolides, which carry several side chains, a single desosamine sugar is attached to the macrolactone ring of MTM and PKM. In addition, the macrolactone scaffold of MTM is smaller than in other macrolides. The unusual structure of MTM and PKM and their simultaneous secretion by S. venezuelae bring about the possibility that two compounds would bind to distinct ribosomal sites...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28924917/high-heterogeneity-in-soil-composition-and-quality-in-different-mangrove-forests-of-venezuela
#19
X L Otero, A Méndez, G N Nóbrega, T O Ferreira, W Meléndez, F Macías
Mangrove forests play an important role in biogeochemical cycles of metals, nutrients, and C in coastal ecosystems. However, these functions could be strongly affected by the mangrove soil degradation. In this study, we performed an intensive sampling characterizing mangrove soils under different types of environment (lagoon/gulf) and vegetation (Rhizophora/Avicennia/dead mangrove) in the Venezuelan coast. To better understand the spatial heterogeneity of the composition and characteristics of the soils, a wide range of the soil attributes were analyzed...
September 18, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28923090/mapping-occurrence-of-taenia-solium-taeniosis-cysticercosis-and-areas-at-risk-of-porcine-cysticercosis-in-central-america-and-the-caribbean-basin
#20
Uffe Christian Braae, Brecht Devleesschauwer, Fortune Sithole, Ziqi Wang, Arve Lee Willingham
BACKGROUND: This study aimed to map the occurrence of Taenia solium taeniosis/cysticercosis at national level within Central America and the Caribbean basin, and to map the distribution of porcine cysticercosis at first-level administrative subdivision level (department level) and the porcine population at risk. This zoonotic parasite is believed to be widely endemic across most of Latin America. However, there is little information readily available for Central America and the Caribbean basin...
September 18, 2017: Parasites & Vectors
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