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leiomyoma intramural

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https://www.readbyqxmd.com/read/29772408/hysteroscopic-myomectomy-of-a-large-submucosal-leiomyoma-with-novel-use-of-fluid-warming
#1
Tess Chase, Stephanie J Estes
Uterine fibroid size is often considered a limiting factor for considering the surgical approach to myomectomy. In this case, a 35-year-old woman presented with heavy menstrual bleeding and desire for fertility. An ultrasound three months prior could not assess the endometrium and suggested leiomyoma. Magnetic resonance imaging of the pelvis identified a fundal submucosal myoma measuring 6.8 × 7.1 × 3.5 cm. A planned staged hysteroscopic resection of the large submucosal fibroid with intramural component was achieved...
May 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29607236/a-case-of-primary-uterina-lymphoma-presenting-with-bleeding-pelvic-pain-and-dysmenorrhea
#2
Lilian Yukari Miura, Miriam Anyury Daquin Maure, Monica Tessmann Zomer, Reitan Ribeiro, Teresa Cristina Santos Cavalcanti, William Kondo
Primary non-Hodgkin's lymphoma (NHL) can arise from lymphatic cells located in solid organs (extranodal) and it accounts for 25 to 35% of all NHL. Primary lymphoma on the female genital tract (PLFGT) is a rare disease, comprising 0.2 to 1.1% of all extranodal lymphomas in the female population. In this paper, the authors report an extremely rare case of a 48-year-old woman who exhibited an abnormal uterine bleeding, pelvic pain, and dysmenorrhea history. The transvaginal ultrasound showed an anteverted uterus measuring 153 cm3 in volume, with intramural leiomyomas...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29550389/predictors-of-long-term-novasure-endometrial-ablation-failure
#3
Charlotte Lybol, Sanne van der Coelen, Anouk Hamelink, Lidewij Ruth Bartelink, Theodoor Elbert Nieboer
STUDY OBJECTIVE: Endometrial ablation using the NovaSure system (Hologic Inc., Marlborough, MA) is 1 of the treatment options for heavy menstrual bleeding (HMB), which has a reported success rate of 81% to 90%. We aimed to identify predictors for NovaSure endometrial ablation failure. This will contribute to a more effective and individualized preoperative counseling. DESIGN: A retrospective multicenter cohort study (Canadian Task Force classification II-2). SETTING: One university hospital and 1 large teaching hospital...
March 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29385977/abnormal-uterine-bleeding-managing-endometrial-dysfunction-and-leiomyomas
#4
Annabelle Brennan, Martha Hickey
Abnormal uterine bleeding refers to any change in the regularity, frequency, heaviness or length of menstruation. There are several potential causes for bleeding disturbance, the two most common being primary endometrial dysfunction and fibroids. Management of abnormal uterine bleeding involves both medical and surgical options and will largely depend on a patient's fertility plans. The use of levonorgestrel-releasing intrauterine devices for heavy menstrual bleeding is increasing in Australia, and they are considered first-line medical management for women accepting of hormonal therapies...
February 5, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29317071/recently-discovered-interstitial-cells-telocytes-as-players-in-the-pathogenesis-of-uterine-leiomyomas
#5
Ivan Varga, Martin Klein, Ladislav Urban, Ludovit Danihel, Stefan Polak, Ludovit Danihel
Uterine telocytes are interstitial cells characterized by a very long cytoplasmic prolongations, which form a 3D network, functionally integrating a wide variety of different cells. Leiomyomas (uterine fibroids) are benign tumors, which pose a huge threat concerning various health problems in women affected by this condition. The exact cause of leiomyomas development is, however, still largely unknown. Therefore, in an attempt to clarify their etiology, we performed an immunohistochemical characterization of telocytes in leiomyomas as well as in normal myometrium...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29177589/ultrasound-guided-core-needle-biopsy-prior-to-thermo-ablative-treatment-of-uterine-tumors-first-results
#6
Christina B Walter, Andreas D Hartkopf, Dorit Schoeller, Bernhard Kraemer, Felix Neis, Florin-Andrei Taran, Keith B Isaacson, Sara Y Brucker, Markus Hahn
PURPOSE: This study aimed at evaluating the diagnostic yield for core needle biopsies of uterine fibroids before laparoscopic radiofrequency volumetric thermal ablation (RFVTA) with the aim of sonographic imaging. This study was in the context of a randomized, prospective, single-center, longitudinal comparative study in which RFVTA and laparoscopic myomectomy for symptomatic uterine fibroids were compared. METHODS: All patients of the RFVTA-arm received a core needle biopsy under the guidance of an intraoperative laparoscopic ultrasound system...
February 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28801323/transvaginal-postpartum-manual-removal-of-a-prolapsed-submucous-leiomyoma-initially-diagnosed-hybrid-predominantly-intramural
#7
Wael Elgonaid, Reem Belkhir, Vincent Boama
We present a rare case of a large infarcted submucous fibroid removed manually after a normal vaginal delivery. This patient was known to have a large postero-fundal hybrid predominantly intramural uterine fibroid, measuring 11 x 10 cm in diameter and diagnosed 2 years prior to last conception. Thirty-five days postpartum, she presented with severe lower abdominal pain and foul smell per vaginum. Abdominal examination revealed a very tender bulky uterus at 24 weeks size, and vaginal examination revealed a big fleshy smelly mass with friable surface just bulging from a dilated cervix...
August 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28790785/a-randomized-control-trial-to-assess-efficacy-of-mifepristone-in-medical-management-of-uterine-fibroid
#8
D Arora, Jaya Chawla, S P S Kochar, J C Sharma
BACKGROUND: Fibroids are the most common benign tumours of uterus. Heavy menstrual bleeding is the commonest concern for which medical attention is sought. Hysterectomies for leiomyoma constitute a third of all hysterectomies. Thus, healthcare cost to society due to uterine leiomyomas is of considerable importance. METHODS: A prospective study was conducted at tertiary care hospital of armed forces. 120 women in pre-menopausal age group with complaints of menorrhagia, Pictorial Bleeding Assessment Chart (PBAC) scoring ≥100 and at least one fibroid ≥2...
July 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28741605/a-rare-case-of-intramural-m%C3%A3-llerian-adenosarcoma-arising-from-adenomyosis-of-the-uterus
#9
Sun-Jae Lee, Ji Y Park
Müllerian adenosarcomas usually arise as polypoid masses in the endometrium of post-menopausal women. Occasionally, these tumors arise in the cervix, vagina, broad and round ligaments, ovaries and rarely in extragenital sites; these cases are generally associated with endometriosis. We experienced a rare case of extraendometrial, intramural adenosarcoma arising in a patient with adenomyosis. A 40-year-old woman presented with sudden-onset suprapubic pain. The imaging findings suggested leiomyoma with cystic degeneration in the uterine fundus...
July 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28700441/leiomyoma-with-bizarre-nuclei-clinical-and-pathologic-features-of-30-patients
#10
Mehmet Kefeli, Sultan Caliskan, Emel Kurtoglu, Levent Yildiz, Arif Kokcu
Leiomyoma with bizarre nuclei (LBN) have significant cytologic atypia, but high mitotic rate and tumor cell necrosis are absent. Although it is a benign leiomyoma variant, recurrent cases have been described. In this study, we investigated the clinical and pathologic features of LBN and compared them with related studies. A total of 30 patients diagnosed with LBN in our department were included in this study. In all cases, clinical data (age, complaint, surgery type), macroscopic features (size, location, number of leiomyomas, necrosis, and hemorrhage), microscopic features (bizarre cell distribution, bizarre cell density, cellularity, mitotic rate, tumor margin, necrosis, nuclear pseudoinclusions, karyorrhectic nuclei, prominent eosinophilic nucleoli with perinucleolar clearing, cytoplasmic eosinophilic inclusions, staghorn vessels, and alveolar-type edema), and follow-up data (recurrence and survival period) were evaluated...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28481790/a-novel-diagnostic-strategy-using-16%C3%AE-18f-fluoro-17-%C3%AE-estradiol-18f-fes-pet-mri-to-achieve-complete-resection-of-intravenous-leiomyomatosis-in-reproductive-age-women
#11
Yoko Chino, Hideaki Tsuyoshi, Tetsuya Tsujikawa, Hidehiko Okazawa, Yoshio Yoshida
Intravenous leiomyomatosis is a life-threatening leiomyoma that grows into the extrauterine venous system. A high recurrence rate has been reported in reproductive-age women who undergo only tumor excision to preserve fertility. Precise diagnosis of tumor extension is essential to achieve complete resection. A 24-year-old woman presented with hypermenorrhea. Contrast-enhanced MRI showed an intramural myoma with worm-like extension into the right parametrium. F-FES PET/MRI accurately depicted the extension with strong FES activity into the right uterine vein, whereas F-FDG PET/MRI excluded the possibility of malignancy...
July 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28471130/non-puerperal-uterine-inversion-due-to-submucous-myoma-in-a-woman-a-case-report
#12
Ayse Kirbas, Korkut Daglar, Ozgur Kara, Ayhan Sucak, Turhan Caglar
Uterine leiomyomas are the most common benign tumor of the female reproductive tract. Their incidence during pregnancy is approximately 2 percent and they are associated with some complications such as preterm labor, placental abruption, fetal malpresentation, obstructed labor, cesarean delivery, and postpartum hemorrhage. They may develop anywhere within the muscular wall of the uterus, including submucosal, intramural, or subserosal areas. Some of the submucous myomas may be pedunculated and eventually may protrude through the cervical canal to the vagina...
July 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28432313/multiple-clinical-characteristics-separate-med12-mutation-positive-and-negative-uterine-leiomyomas
#13
Hanna-Riikka Heinonen, Annukka Pasanen, Oskari Heikinheimo, Tomas Tanskanen, Kimmo Palin, Jaana Tolvanen, Pia Vahteristo, Jari Sjöberg, Esa Pitkänen, Ralf Bützow, Netta Mäkinen, Lauri A Aaltonen
Up to 86% of uterine leiomyomas harbour somatic mutations in mediator complex subunit 12 (MED12). These mutations have been associated with conventional histology, smaller tumour size, and larger number of tumours within the uterus. Prior studies, with limited sample sizes, have failed to detect associations between other clinical features and MED12 mutations. Here, we prospectively collected 763 uterine leiomyomas and the corresponding normal myometrial tissue from 244 hysterectomy patients, recorded tumour characteristics, collected clinical data from medical records, and screened the tissue samples for MED12 mutations to assess potential associations between clinical variables and mutation status...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28406809/hysteroscopy-for-abnormal-uterine-bleeding-and-fibroids
#14
Lindsey N Valentine, Linda D Bradley
Operative hysteroscopy is a safe and effective minimally invasive treatment option for submucosal and intramural leiomyomas. We discuss preoperative evaluation, fluid management, postoperative complications, preventative measures, and hysteroscopic outcomes. Technical instructions and tips for successful hysteroscopy, as well as the various equipment options most commonly utilized in the United States, are also reviewed.
June 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28373126/total-laparoscopic-treatment-with-cystotomy-for-intramural-bladder-leiomyoma
#15
Kiyoshi Kanno, Masaaki Andou, Shiori Yanai, Akira Shirane, Saori Nakajima, Keiko Ebisawa, Tomonori Hada, Yoshiaki Ota
No abstract text is available yet for this article.
January 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28250727/leiomyoma-in-the-retzius-space
#16
Dobrosława Sikora-Szczęśniak
Parauterine location of leiomyomas is observed to be an extremely rare clinical condition. However, when benign or malignant primary tumours are detected in that area, they are often found in the Retzius space. There have been only six cases of leiomyomas in the Retzius space reported in the literature so far. The paper presents one such leiomyoma case located in the Retzius space. This extremely rare location of the tumour justifies its presentation. The medical records of the patient treated in the outpatient's obstetrics and gynaecology (ob-gyn) clinic, her case history, and hospital records, supplemented by information obtained from the patient's daughter, were analysed...
December 2016: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28114870/endometrial-myomectomy-a-novel-surgical-method-during-cesarean-section
#17
Şafak Hatırnaz, Oğuz Güler, Serdar Başaranoğlu, Cengiz Tokgöz, Gokhan S Kılıç
STUDY OBJECTIVE: Comparing surgical outcomes of a novel surgical technique endometrial myomectomy (EM) to serosal myomectomy (SM) during ceserean section (CS). DESIGN: Retrospective cohort study (Canadian task force classification level II 1). SETTING: Private hospital. PATIENTS: Fourty-six women with leiomyomas during cesarean section Interventions: Endometrial myomectomy and serosal myomectomy during cesarean section between 2013 and 2016...
February 9, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28096828/intramural-esophageal-tumors
#18
Mariusz P Łochowski, Katarzyna Kozak, Marek Rębowski, Józef Kozak
INTRODUCTION: Intramural esophageal tumors (IET) are located between unchanged mucous membrane and muscularis mucosae. They can be both benign and malignant. AIM: To evaluate diagnostic and therapeutic difficulties of IET. MATERIAL AND METHODS: During the years 2010-2015, 11 patients with IET were treated in our clinic. Diagnostics included gastroscopy, computed tomography of the chest, endoscopic ultrasound (EUS) guided fine needle biopsy, and positron emission tomography (PET) of the esophagus in cases with no histopathological confirmation...
December 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28010141/differential-expression-of-visfatin-leptin-stromal-cell-derived-factor-1%C3%AE-endothelial-nitric-oxide-synthase-and-vascular-endothelial-growth-factor-in-human-leiomyomas
#19
Bo Sun Joo, Min Jung Park, Chang-Woon Kim, Kyu Sup Lee, Jong Kil Joo
AIM: This study was aimed to understand expressions of the visfatin, leptin, stromal cell derived factor (SDF)-1α, endothelial nitric oxide synthase (eNOS), and vascular endothelial growth factor (VEGF) in human uterine leiomyomas (UL) and normal myometrium. METHOD: This study investigated expression of visfatin, leptin, SDF-1α, eNOS and VEGF in 23 uterine leiomyoma patients and 10 normal myometrium by RT-PCR and western blot. Messenger RNA transcripts of SDF-1α, eNOS, VEGF and hypoxia inducible factor-1α (HIF-1α) were analyzed according to the size of UL by real-time PCR...
April 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28000025/two-novel-classification-systems-for-uterine-fibroids-and-subsequent-uterine-reconstruction-after-myomectomy
#20
Ingolf Juhasz-Böss, Peter Jungmann, Julia Radosa, Anika von Heesen, Russalina Ströder, Stephanie Juhasz-Böss, Gabriele Meyberg-Solomayer, Erich Solomayer
OBJECTIVE: Laparoscopic approaches are the gold standard surgical treatment for intramural and subserous fibroids, whereas submucosal myomas can be treated via hysteroscopy. Removal of intramural myomas often requires a subsequent reconstruction of the uterine wall that ranges from single- to multiple-layer sutures to complex reconstructions. Several classification systems are currently used to characterize uterine fibroids, all of which focus on the assessment of submucosal fibroids during hysteroscopic myomectomy...
March 2017: Archives of Gynecology and Obstetrics
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