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https://www.readbyqxmd.com/read/29177162/surgical-treatment-of-small-intestinal-neuroendocrine-tumors-g1-g2
#1
REVIEW
Andreas Selberherr, Martin B Niederle, Bruno Niederle
Although the majority of neuroendocrine tumors of the small intestine (siNETs) classified as low-grade G1 or G2 show slow local growth, they are frequently diagnosed at an advanced stage of metastatic disease. The surgical treatment is curative in stages I-III or palliative in stage IV in an attempt to avoid local complications of bowel obstruction and ischemia of the small bowel by unremoved lymph node metastases. Individualized surgical procedures performed by experienced surgeons considering tumor multifocality and the primary extent of lymph node metastases along the mesenteric vessels are recommended to remove as much tumor volume as possible, while avoiding major complications intraoperatively and small bowel syndrome postoperatively...
October 2017: Visceral Medicine
https://www.readbyqxmd.com/read/29045520/overall-survival-analysis-of-exam-a-phase-iii-trial-of-cabozantinib-in-patients-with-radiographically-progressive-medullary-thyroid-carcinoma
#2
M Schlumberger, R Elisei, S Müller, P Schöffski, M Brose, M Shah, L Licitra, J Krajewska, M C Kreissl, B Niederle, E E W Cohen, L Wirth, H Ali, D O Clary, Y Yaron, M Mangeshkar, D Ball, B Nelkin, S Sherman
Background: Primary analysis of the double-blind, phase III Efficacy of XL184 (Cabozantinib) in Advanced Medullary Thyroid Cancer (EXAM) trial demonstrated significant improvement in progression-free survival with cabozantinib versus placebo in patients with progressive medullary thyroid cancer (MTC). Final analysis of overall survival (OS), a key secondary endpoint, was carried out after long-term follow-up. Patients and methods: EXAM compared cabozantinib with placebo in 330 patients with documented radiographic progression of metastatic MTC...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28956240/nisin-z-produced-by-lactococcus-lactis-from-bullfrog-hatchery-is-active-against-citrobacter-freundii-a-red-leg-syndrome-related-pathogen
#3
Gabriel Quintana, Maria V Niederle, Carlos J Minahk, Gianluca Picariello, María E F Nader-Macías, Sergio E Pasteris
Lactococcus lactis subsp. lactis CRL 1584 isolated from a bullfrog hatchery produces a bacteriocin that inhibits both indigenous Citrobacter freundii (a Red-Leg Syndrome related pathogen) and Lactobacillus plantarum, and Listeria monocytogenes as well. Considering that probiotics requires high cell densities and/or bacteriocin concentrations, the effect of the temperature on L. lactis growth and bacteriocin production was evaluated to find the optimal conditions. Thus, the growth rate was maximal at 36 °C, whereas the highest biomass and bacteriocin activity was achieved between 20 and 30 °C and 20-25 °C, respectively...
September 27, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28906021/primary-hyperparathyroidism-dynamic-postoperative-metabolic-changes
#4
Reto M Kaderli, Philipp Riss, Angelika Geroldinger, Andreas Selberherr, Christian Scheuba, Bruno Niederle
OBJECTIVE: Little is known about the natural changes in parathyroid function after successful parathyroid surgery for primary hyperparathyroidism. The association of intact parathyroid hormone (iPTH) and calcium (Ca) with "temporary hypoparathyroidism" and "hungry bone syndrome" (HBS) was evaluated. DESIGN: Potential risk factors for temporary hypoparathyroidism and HBS were evaluated by taking blood samples before surgery, intra-operatively, at postoperative day (POD) 1, at POD 5 to 7, in postoperative week (POW) 8 and in postoperative month (POM) 6...
September 14, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28895618/acute-respiratory-distress-in-a-child-with-h3n2-infection
#5
SimoneS Schüller, Azadeh Hojreh, Martin Niederle, Zsolt Szepfalusi, Kurosh Paya, Andreas Böck
No abstract text is available yet for this article.
September 11, 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28877925/the-impact-of-vitamin-d-status-on-hungry-bone-syndrome-after-surgery-for-primary-hyperparathyroidism
#6
Reto Martin Kaderli, Philipp Riss, Daniela Dunkler, Peter Pietschmann, Andreas Selberherr, Christian Scheuba, Bruno Niederle
OBJECTIVE: Prolonged hypocalcemia but normal intact parathyroid hormone (iPTH) levels after surgery for primary hyperparathyroidism (PHPT) are referred to as 'hungry bone syndrome' (HBS). The aim was to evaluate preoperative risk factors for HBS with a focus on the impact of 25-hydroxyvitamin D (25(OH)D) deficiency. DESIGN: Patients having undergone initial successful surgery for sporadic PHPT within 6 years were considered for retrospective analysis. METHODS: A total of 385 patients were evaluated, of whom 33 (8...
January 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28474313/expression-of-hypoxia-associated-protein-hif-1%C3%AE-in-follicular-thyroid-cancer-is-associated-with-distant-metastasis
#7
Aumayr Klaus, Osmen Fathi, Traub-Weidinger Tatjana, Niederle Bruno, Koperek Oskar
Follicular thyroid carcinomas (FTCs) are the second most common malignant neoplasia of the thyroid and in general its prognosis is quite favorable. However, the occurrence of metastases or non-responsiveness to radioiodine therapy worsens the prognosis considerably. We evaluated immunohistochemically the expression of hypoxia-associated proteins by hypoxia-induced factor 1α (HIF-1α), the stroma-remodeling marker Tenascin C, as well as markers for the epithelial-mesenchymal transition (EMT), namely E-cadherin and slug in a series of 59 sporadic FTCs...
May 4, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28383779/factors-influencing-pre-operative-urinary-calcium-excretion-in-primary-hyperparathyroidism
#8
Reto M Kaderli, Philipp Riss, Angelika Geroldinger, Andreas Selberherr, Christian Scheuba, Bruno Niederle
OBJECTIVE: Normal or elevated 24-hour urinary calcium (Ca) excretion is a diagnostic marker in primary hyperparathyroidism (PHPT). It is used to distinguish familial hypocalciuric hypercalcaemia (FHH) from PHPT by calculating the Ca/creatinine clearance ratio (CCCR). The variance of CCCR in patients with PHPT is considerable. The aim of this study was to analyse the parameters affecting CCCR in patients with PHPT. DESIGN: The data were collected prospectively. Patients with sporadic PHPT undergoing successful surgery were included in a retrospective analysis...
July 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28237989/enets-consensus-guidelines-for-standard-of-care-in-neuroendocrine-tumours-surgery-for-small-intestinal-and-pancreatic-neuroendocrine-tumours
#9
Stefano Partelli, Detlef K Bartsch, Jaume Capdevila, Jie Chen, Ulrich Knigge, Bruno Niederle, Els J M Nieveen van Dijkum, Ulrich-Frank Pape, Andreas Pascher, John Ramage, Nick Reed, Philippe Ruszniewski, Jean-Yves Scoazec, Christos Toumpanakis, Reza Kianmanesh, Massimo Falconi
No abstract text is available yet for this article.
February 25, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28222443/enets-consensus-recommendations-for-the-standards-of-care-in-neuroendocrine-neoplasms-follow-up-and-documentation
#10
U Knigge, J Capdevila, D K Bartsch, E Baudin, J Falkerby, R Kianmanesh, B Kos-Kudla, B Niederle, E Nieveen van Dijkum, D O'Toole, A Pascher, N Reed, A Sundin, M-P Vullierme
No abstract text is available yet for this article.
February 17, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/27734157/-silent-kidney-stones-in-asymptomatic-primary-hyperparathyroidism-a-comparison-of-multidetector-computed-tomography-and-ultrasound
#11
Andreas Selberherr, Marcus Hörmann, Gerhard Prager, Philipp Riss, Christian Scheuba, Bruno Niederle
PURPOSE: The purpose of this study was to demonstrate the high number of kidney stones in primary hyperparathyroidism (PHPT) and the low number of in fact "asymptomatic" patients. METHODS: Forty patients with PHPT (28 female, 12 male; median age 58 (range 33-80) years; interquartile range 17 years [51-68]) without known symptoms of kidney stones prospectively underwent multidetector computed tomography (MDCT) and ultrasound (US) examinations of the urinary tract prior to parathyroid surgery...
March 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27539746/expression-of-somatostatin-receptor-2a-in-medullary-thyroid-carcinoma-is-associated-with-lymph-node-metastasis
#12
Merima Herac, Bruno Niederle, Markus Raderer, Michael Krebs, Klaus Kaserer, Oskar Koperek
Medullary carcinoma (MTC) is an aggressive tumour that derives from the thyroid parafollicular calcitonin-secreting cells (C cells). Lymph node metastasis may occur early in disease pathogenesis and is one of the most important negative prognostic parameters. Surgery is the only curative therapy while chemotherapeutic options are limited. Neuroendocrine differentiated C cells may express somatostatin receptors (SSTR), which have a wide range of biological actions including inhibitory effects on cell survival and angiogenesis and antiproliferative effects on cancer cell lines...
October 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27532222/sustained-response-to-vemurafenib-in-a-braf-v600e-mutated-anaplastic-thyroid-carcinoma-patient
#13
Gerald W Prager, Oskar Koperek, Marius E Mayerhoefer, Leonhard Muellauer, Fritz Wrba, Bruno Niederle, Christoph C Zielinski, Markus Raderer
No abstract text is available yet for this article.
October 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27393573/prophylactic-first-step-central-neck-dissection-level-6-does-not-increase-morbidity-after-total-thyroidectomy
#14
Andreas Selberherr, Philipp Riss, Christian Scheuba, Bruno Niederle
BACKGROUND: In terms of morbidity, prophylactic central neck dissection (CND; level 6) in potentially malignant thyroid disease is discussed controversially. The rates of (transient and permanent) hypoparathyroidism and palsy of the recurrent laryngeal nerve (RLN) after "first-step" (FS-)CND are analyzed in this study. METHODS: Bilateral and unilateral FSCND, i.e., lymph node dissection along the RLN before (total) thyroidectomy, was performed bilaterally in 68 (group 1) and unilaterally in 44 patients (group 2), respectively...
November 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27090254/32nd-international-austrian-winter-symposium-zell-am-see-the-netherlands-20-23-january-2016
#15
W Langsteger, A Rezaee, W Loidl, H S Geinitz, F Fitz, M Steinmair, G Broinger, L Pallwien-Prettner, M Beheshti, L Imamovic, M Beheshti, G Rendl, D Hackl, O Tsybrovsky, M Steinmair, K Emmanuel, F Moinfar, C Pirich, W Langsteger, A Bytyqi, G Karanikas, M Mayerhöfer, O Koperek, B Niederle, M Hartenbach, T Beyer, K Herrmann, J Czernin, I Rausch, P Rust, M D DiFranco, M Lassen, A Stadlbauer, M E Mayerhöfer, M Hartenbach, M Hacker, T Beyer, K Binzel, R Magnussen, W Wei, M U Knopp, D C Flanigan, C Kaeding, M V Knopp, A Leisser, M Nejabat, M Hartenbach, G Kramer, M Krainer, M Hacker, A Haug, Wencke Lehnert, Karl Schmidt, Sharok Kimiaei, Marcus Bronzel, Andreas Kluge, C L Wright, K Binzel, J Zhang, Evan Wuthrick, Piotr Maniawski, M V Knopp, M Blaickner, E Rados, A Huber, M Dulovits, H Kulkarni, S Wiessalla, C Schuchardt, R P Baum, B Knäusl, D Georg, M Bauer, B Wulkersdorfer, W Wadsak, C Philippe, H Haslacher, M Zeitlinger, O Langer, M Bauer, M Feldmann, R Karch, W Wadsak, M Zeitlinger, M J Koepp, M-C Asselin, E Pataraia, O Langer, M Zeilinger, C Philippe, M Dumanic, F Pichler, J Pilz, M Hacker, W Wadsak, M Mitterhauser, L Nics, B Steiner, M Hacker, M Mitterhauser, W Wadsak, A Traxl, Thomas Wanek, Kushtrim Kryeziu, Severin Mairinger, Johann Stanek, Walter Berger, Claudia Kuntner, Oliver Langer, S Mairinger, T Wanek, A Traxl, M Krohn, J Stanek, T Filip, M Sauberer, C Kuntner, J Pahnke, O Langer, D Svatunek, C Denk, M Wilkovitsch, T Wanek, T Filip, C Kuntner-Hannes, J Fröhlich, H Mikula, C Denk, D Svatunek, T Wanek, S Mairinger, J Stanek, T Filip, J Fröhlich, H Mikula, C Kuntner-Hannes, T Balber, J Singer, J Fazekas, C Rami-Mark, N Berroterán-Infante, E Jensen-Jarolim, W Wadsak, M Hacker, H Viernstein, M Mitterhauser, C Denk, D Svatunek, B Sohr, H Mikula, J Fröhlich, T Wanek, C Kuntner-Hannes, T Filip, S Pfaff, C Philippe, M Mitterhauser, M Hartenbach, M Hacker, W Wadsak, T Wanek, E Halilbasic, M Visentin, S Mairinger, B Stieger, C Kuntner, M Trauner, O Langer, P Lam, M Aistleitner, R Eichinger, C Artner, H Eidherr, C Vraka, A Haug, M Mitterhauser, L Nics, M Hartenbach, M Hacker, W Wadsak, H Kvaternik, R Müller, D Hausberger, C Zink, R M Aigner, U Cossío, M Asensio, A Montes, S Akhtar, Y Te Welscher, R van Nostrum, V Gómez-Vallejo, J Llop, F VandeVyver, T Barclay, N Lippens, M Troch, L Hehenwarter, B Egger, J Holzmannhofer, M Rodrigues-Radischat, C Pirich, N Pötsch, I Rausch, D Wilhelm, M Weber, J Furtner, G Karanikas, A Wöhrer, M Mitterhauser, M Hacker, T Traub-Weidinger, T Cassou-Mounat, S Balogova, V Nataf, M Calzada, V Huchet, K Kerrou, J-Y Devaux, M Mohty, L Garderet, J-N Talbot, S Stanzel, G Pregartner, T Schwarz, V Bjelic-Radisic, B Liegl-Atzwanger, R Aigner, S Stanzel, F Quehenberger, R M Aigner, A Koljević Marković, Milica Janković, V Miler Jerković, M Paskaš, G Pupić, R Džodić, D Popović, M C Fornito, D Familiari, P Koranda, H Polzerová, I Metelková, L Henzlová, R Formánek, E Buriánková, M Kamínek, W H Thomson, C Lewis, W H Thomson, J O'Brien, G James, A Notghi, H Huber, I Stelzmüller, R Wunn, M Mandl, F Fellner, B Lamprecht, M Gabriel, M C Fornito, G Leonardi, W H Thomson, J O'Brien, G James, J Hudzietzová, J Sabol, M Fülöp
A1 68Ga-PSMA PET/CT in staging and restaging of Prostate Cancer Patients: comparative study with 18F-Choline PET/CTW Langsteger, A Rezaee, W Loidl, HS Geinitz, F Fitz, M Steinmair, G Broinger, L Pallwien-Prettner, M BeheshtiA2 F18 Choline PET - CT: an accurate diagnostic tool for the detection of parathyroid adenoma?L Imamovic, M Beheshti, G Rendl, D Hackl, O Tsybrovsky, M Steinmair, K Emmanuel, F Moinfar, C Pirich, W LangstegerA3 [18F]Fluoro-DOPA-PET/CT in the primary diagnosis of medullary thyroid carcinomaA Bytyqi, G Karanikas, M Mayerhöfer, O Koperek, B Niederle, M HartenbachA4 Variations of clinical PET/MR operations: An international survey on the clinical utilization of PET/MRIT Beyer, K Herrmann, J CzerninA5 Standard Dixon-based attenuation correction in combined PET/MRI: Reproducibility and the possibility of Lean body mass estimationI Rausch, P Rust, MD DiFranco, M Lassen, A Stadlbauer, ME Mayerhöfer, M Hartenbach, M Hacker, T BeyerA6 High resolution digital FDG PET/MRI imaging for assessment of ACL graft viabilityK Binzel, R Magnussen, W Wei, MU Knopp, DC Flanigan, C Kaeding, MV KnoppA7 Using pre-existing hematotoxicity as predictor for severe side effects and number of treatment cycles of Xofigo therapyA Leisser, M Nejabat, M Hartenbach, G Kramer, M Krainer, M Hacker, A HaugA8 QDOSE - comprehensive software solution for internal dose assessmentWencke Lehnert, Karl Schmidt, Sharok Kimiaei, Marcus Bronzel, Andreas KlugeA9 Clinical impact of Time-of-Flight on next-generation digital PET imaging of Yttrium-90 radioactivity following liver radioembolizationCL Wright, K Binzel, J Zhang, Evan Wuthrick, Piotr Maniawski, MV KnoppA10 Snakes in patients! Lessons learned from programming active contours for automated organ segmentationM Blaickner, E Rados, A Huber, M Dulovits, H Kulkarni, S Wiessalla, C Schuchardt, RP Baum, B Knäusl, D GeorgA11 Influence of a genetic polymorphism on brain uptake of the dual ABCB1/ABCG2 substrate [11C]tariquidarM Bauer, B Wulkersdorfer, W Wadsak, C Philippe, H Haslacher, M Zeitlinger, O LangerA12 Outcome prediction of temporal lobe epilepsy surgery from P-glycoprotein activity...
April 2016: EJNMMI Research
https://www.readbyqxmd.com/read/26921840/the-influence-of-thiazide-intake-on-calcium-and-parathyroid-hormone-levels-in-patients-with-primary-hyperparathyroidism
#16
Philipp Riss, Michael Kammer, Andreas Selberherr, Christoph Bichler, Reto Kaderli, Christian Scheuba, Bruno Niederle
OBJECTIVE: The effects of thiazide medication in patients with primary hyperparathyroidism (PHPT) have so far not been elucidated. The aim of this study was to analyse the extent to which the administration of thiazides may influence biochemical parameters and therefore the diagnosis of PHPT in a large cohort of patients. DESIGN AND PATIENTS: The biochemical parameters of 1066 patients with PHPT were analysed, and drug history was documented. Calcium (Ca)/creatinine clearance ratio (CCCR) was calculated...
August 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/26758972/enets-consensus-guidelines-update-for-neuroendocrine-neoplasms-of-the-jejunum-and-ileum
#17
B Niederle, U-F Pape, F Costa, D Gross, F Kelestimur, U Knigge, K Öberg, M Pavel, A Perren, C Toumpanakis, J O'Connor, D O'Toole, E Krenning, N Reed, R Kianmanesh
No abstract text is available yet for this article.
2016: Neuroendocrinology
https://www.readbyqxmd.com/read/26731334/enets-consensus-guidelines-for-high-grade-gastroenteropancreatic-neuroendocrine-tumors-and-neuroendocrine-carcinomas
#18
R Garcia-Carbonero, H Sorbye, E Baudin, E Raymond, B Wiedenmann, B Niederle, E Sedlackova, C Toumpanakis, M Anlauf, J B Cwikla, M Caplin, D O'Toole, A Perren
No abstract text is available yet for this article.
2016: Neuroendocrinology
https://www.readbyqxmd.com/read/26730583/enets-consensus-guidelines-for-neuroendocrine-neoplasms-of-the-appendix-excluding-goblet-cell-carcinomas
#19
U-F Pape, B Niederle, F Costa, D Gross, F Kelestimur, R Kianmanesh, U Knigge, K Öberg, M Pavel, A Perren, C Toumpanakis, J O'Connor, E Krenning, N Reed, D O'Toole
No abstract text is available yet for this article.
2016: Neuroendocrinology
https://www.readbyqxmd.com/read/26661066/new-feed-sources-key-to-ambitious-climate-targets
#20
Brian J Walsh, Felicjan Rydzak, Amanda Palazzo, Florian Kraxner, Mario Herrero, Peer M Schenk, Philippe Ciais, Ivan A Janssens, Josep Peñuelas, Anneliese Niederl-Schmidinger, Michael Obersteiner
Net carbon sinks capable of avoiding dangerous perturbation of the climate system and preventing ocean acidification have been identified, but they are likely to be limited by resource constraints (Nature 463:747-756, 2010). Land scarcity already creates tension between food security and bioenergy production, and this competition is likely to intensify as populations and the effects of climate change expand. Despite research into microalgae as a next-generation energy source, the land-sparing consequences of alternative sources of livestock feed have been overlooked...
December 2015: Carbon Balance and Management
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