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https://www.readbyqxmd.com/read/27734157/-silent-kidney-stones-in-asymptomatic-primary-hyperparathyroidism-a-comparison-of-multidetector-computed-tomography-and-ultrasound
#1
Andreas Selberherr, Marcus Hörmann, Gerhard Prager, Philipp Riss, Christian Scheuba, Bruno Niederle
PURPOSE: The purpose of this study was to demonstrate the high number of kidney stones in primary hyperparathyroidism (PHPT) and the low number of in fact "asymptomatic" patients. METHODS: Forty patients with PHPT (28 female, 12 male; median age 58 (range 33-80) years; interquartile range 17 years [51-68]) without known symptoms of kidney stones prospectively underwent multidetector computed tomography (MDCT) and ultrasound (US) examinations of the urinary tract prior to parathyroid surgery...
October 12, 2016: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/27539746/expression-of-somatostatin-receptor-2a-in-medullary-thyroid-carcinoma-is-associated-with-lymph-node-metastasis
#2
Merima Herac, Bruno Niederle, Markus Raderer, Michael Krebs, Klaus Kaserer, Oskar Koperek
Medullary carcinoma (MTC) is an aggressive tumour that derives from the thyroid parafollicular calcitonin-secreting cells (C cells). Lymph node metastasis may occur early in disease pathogenesis and is one of the most important negative prognostic parameters. Surgery is the only curative therapy while chemotherapeutic options are limited. Neuroendocrine differentiated C cells may express somatostatin receptors (SSTR), which have a wide range of biological actions including inhibitory effects on cell survival and angiogenesis and antiproliferative effects on cancer cell lines...
October 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27532222/sustained-response-to-vemurafenib-in-a-braf-v600e-mutated-anaplastic-thyroid-carcinoma-patient
#3
Gerald W Prager, Oskar Koperek, Marius E Mayerhoefer, Leonhard Muellauer, Fritz Wrba, Bruno Niederle, Christoph C Zielinski, Markus Raderer
No abstract text is available yet for this article.
October 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27393573/prophylactic-first-step-central-neck-dissection-level-6-does-not-increase-morbidity-after-total-thyroidectomy
#4
Andreas Selberherr, Philipp Riss, Christian Scheuba, Bruno Niederle
BACKGROUND: In terms of morbidity, prophylactic central neck dissection (CND; level 6) in potentially malignant thyroid disease is discussed controversially. The rates of (transient and permanent) hypoparathyroidism and palsy of the recurrent laryngeal nerve (RLN) after "first-step" (FS-)CND are analyzed in this study. METHODS: Bilateral and unilateral FSCND, i.e., lymph node dissection along the RLN before (total) thyroidectomy, was performed bilaterally in 68 (group 1) and unilaterally in 44 patients (group 2), respectively...
July 8, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27090254/32nd-international-austrian-winter-symposium-zell-am-see-the-netherlands-20-23-january-2016
#5
W Langsteger, A Rezaee, W Loidl, H S Geinitz, F Fitz, M Steinmair, G Broinger, L Pallwien-Prettner, M Beheshti, L Imamovic, M Beheshti, G Rendl, D Hackl, O Tsybrovsky, M Steinmair, K Emmanuel, F Moinfar, C Pirich, W Langsteger, A Bytyqi, G Karanikas, M Mayerhöfer, O Koperek, B Niederle, M Hartenbach, T Beyer, K Herrmann, J Czernin, I Rausch, P Rust, M D DiFranco, M Lassen, A Stadlbauer, M E Mayerhöfer, M Hartenbach, M Hacker, T Beyer, K Binzel, R Magnussen, W Wei, M U Knopp, D C Flanigan, C Kaeding, M V Knopp, A Leisser, M Nejabat, M Hartenbach, G Kramer, M Krainer, M Hacker, A Haug, Wencke Lehnert, Karl Schmidt, Sharok Kimiaei, Marcus Bronzel, Andreas Kluge, C L Wright, K Binzel, J Zhang, Evan Wuthrick, Piotr Maniawski, M V Knopp, M Blaickner, E Rados, A Huber, M Dulovits, H Kulkarni, S Wiessalla, C Schuchardt, R P Baum, B Knäusl, D Georg, M Bauer, B Wulkersdorfer, W Wadsak, C Philippe, H Haslacher, M Zeitlinger, O Langer, M Bauer, M Feldmann, R Karch, W Wadsak, M Zeitlinger, M J Koepp, M-C Asselin, E Pataraia, O Langer, M Zeilinger, C Philippe, M Dumanic, F Pichler, J Pilz, M Hacker, W Wadsak, M Mitterhauser, L Nics, B Steiner, M Hacker, M Mitterhauser, W Wadsak, A Traxl, Thomas Wanek, Kushtrim Kryeziu, Severin Mairinger, Johann Stanek, Walter Berger, Claudia Kuntner, Oliver Langer, S Mairinger, T Wanek, A Traxl, M Krohn, J Stanek, T Filip, M Sauberer, C Kuntner, J Pahnke, O Langer, D Svatunek, C Denk, M Wilkovitsch, T Wanek, T Filip, C Kuntner-Hannes, J Fröhlich, H Mikula, C Denk, D Svatunek, T Wanek, S Mairinger, J Stanek, T Filip, J Fröhlich, H Mikula, C Kuntner-Hannes, T Balber, J Singer, J Fazekas, C Rami-Mark, N Berroterán-Infante, E Jensen-Jarolim, W Wadsak, M Hacker, H Viernstein, M Mitterhauser, C Denk, D Svatunek, B Sohr, H Mikula, J Fröhlich, T Wanek, C Kuntner-Hannes, T Filip, S Pfaff, C Philippe, M Mitterhauser, M Hartenbach, M Hacker, W Wadsak, T Wanek, E Halilbasic, M Visentin, S Mairinger, B Stieger, C Kuntner, M Trauner, O Langer, P Lam, M Aistleitner, R Eichinger, C Artner, H Eidherr, C Vraka, A Haug, M Mitterhauser, L Nics, M Hartenbach, M Hacker, W Wadsak, H Kvaternik, R Müller, D Hausberger, C Zink, R M Aigner, U Cossío, M Asensio, A Montes, S Akhtar, Y Te Welscher, R van Nostrum, V Gómez-Vallejo, J Llop, F VandeVyver, T Barclay, N Lippens, M Troch, L Hehenwarter, B Egger, J Holzmannhofer, M Rodrigues-Radischat, C Pirich, N Pötsch, I Rausch, D Wilhelm, M Weber, J Furtner, G Karanikas, A Wöhrer, M Mitterhauser, M Hacker, T Traub-Weidinger, T Cassou-Mounat, S Balogova, V Nataf, M Calzada, V Huchet, K Kerrou, J-Y Devaux, M Mohty, L Garderet, J-N Talbot, S Stanzel, G Pregartner, T Schwarz, V Bjelic-Radisic, B Liegl-Atzwanger, R Aigner, S Stanzel, F Quehenberger, R M Aigner, A Koljević Marković, Milica Janković, V Miler Jerković, M Paskaš, G Pupić, R Džodić, D Popović, M C Fornito, D Familiari, P Koranda, H Polzerová, I Metelková, L Henzlová, R Formánek, E Buriánková, M Kamínek, W H Thomson, C Lewis, W H Thomson, J O'Brien, G James, A Notghi, H Huber, I Stelzmüller, R Wunn, M Mandl, F Fellner, B Lamprecht, M Gabriel, M C Fornito, G Leonardi, W H Thomson, J O'Brien, G James, J Hudzietzová, J Sabol, M Fülöp
A1 68Ga-PSMA PET/CT in staging and restaging of Prostate Cancer Patients: comparative study with 18F-Choline PET/CTW Langsteger, A Rezaee, W Loidl, HS Geinitz, F Fitz, M Steinmair, G Broinger, L Pallwien-Prettner, M BeheshtiA2 F18 Choline PET - CT: an accurate diagnostic tool for the detection of parathyroid adenoma?L Imamovic, M Beheshti, G Rendl, D Hackl, O Tsybrovsky, M Steinmair, K Emmanuel, F Moinfar, C Pirich, W LangstegerA3 [18F]Fluoro-DOPA-PET/CT in the primary diagnosis of medullary thyroid carcinomaA Bytyqi, G Karanikas, M Mayerhöfer, O Koperek, B Niederle, M HartenbachA4 Variations of clinical PET/MR operations: An international survey on the clinical utilization of PET/MRIT Beyer, K Herrmann, J CzerninA5 Standard Dixon-based attenuation correction in combined PET/MRI: Reproducibility and the possibility of Lean body mass estimationI Rausch, P Rust, MD DiFranco, M Lassen, A Stadlbauer, ME Mayerhöfer, M Hartenbach, M Hacker, T BeyerA6 High resolution digital FDG PET/MRI imaging for assessment of ACL graft viabilityK Binzel, R Magnussen, W Wei, MU Knopp, DC Flanigan, C Kaeding, MV KnoppA7 Using pre-existing hematotoxicity as predictor for severe side effects and number of treatment cycles of Xofigo therapyA Leisser, M Nejabat, M Hartenbach, G Kramer, M Krainer, M Hacker, A HaugA8 QDOSE - comprehensive software solution for internal dose assessmentWencke Lehnert, Karl Schmidt, Sharok Kimiaei, Marcus Bronzel, Andreas KlugeA9 Clinical impact of Time-of-Flight on next-generation digital PET imaging of Yttrium-90 radioactivity following liver radioembolizationCL Wright, K Binzel, J Zhang, Evan Wuthrick, Piotr Maniawski, MV KnoppA10 Snakes in patients! Lessons learned from programming active contours for automated organ segmentationM Blaickner, E Rados, A Huber, M Dulovits, H Kulkarni, S Wiessalla, C Schuchardt, RP Baum, B Knäusl, D GeorgA11 Influence of a genetic polymorphism on brain uptake of the dual ABCB1/ABCG2 substrate [11C]tariquidarM Bauer, B Wulkersdorfer, W Wadsak, C Philippe, H Haslacher, M Zeitlinger, O LangerA12 Outcome prediction of temporal lobe epilepsy surgery from P-glycoprotein activity...
April 2016: EJNMMI Research
https://www.readbyqxmd.com/read/26921840/the-influence-of-thiazide-intake-on-calcium-and-parathyroid-hormone-levels-in-patients-with-primary-hyperparathyroidism
#6
Philipp Riss, Michael Kammer, Andreas Selberherr, Christoph Bichler, Reto Kaderli, Christian Scheuba, Bruno Niederle
OBJECTIVE: The effects of thiazide medication in patients with primary hyperparathyroidism (PHPT) have so far not been elucidated. The aim of this study was to analyse the extent to which the administration of thiazides may influence biochemical parameters and therefore the diagnosis of PHPT in a large cohort of patients. DESIGN AND PATIENTS: The biochemical parameters of 1066 patients with PHPT were analysed, and drug history was documented. Calcium (Ca)/creatinine clearance ratio (CCCR) was calculated...
August 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/26758972/enets-consensus-guidelines-update-for-neuroendocrine-neoplasms-of-the-jejunum-and-ileum
#7
B Niederle, U-F Pape, F Costa, D Gross, F Kelestimur, U Knigge, K Öberg, M Pavel, A Perren, C Toumpanakis, J O'Connor, D O'Toole, E Krenning, N Reed, R Kianmanesh
No abstract text is available yet for this article.
2016: Neuroendocrinology
https://www.readbyqxmd.com/read/26731334/enets-consensus-guidelines-for-high-grade-gastroenteropancreatic-neuroendocrine-tumors-and-neuroendocrine-carcinomas
#8
R Garcia-Carbonero, H Sorbye, E Baudin, E Raymond, B Wiedenmann, B Niederle, E Sedlackova, C Toumpanakis, M Anlauf, J B Cwikla, M Caplin, D O'Toole, A Perren
No abstract text is available yet for this article.
2016: Neuroendocrinology
https://www.readbyqxmd.com/read/26730583/enets-consensus-guidelines-for-neuroendocrine-neoplasms-of-the-appendix-excluding-goblet-cell-carcinomas
#9
U-F Pape, B Niederle, F Costa, D Gross, F Kelestimur, R Kianmanesh, U Knigge, K Öberg, M Pavel, A Perren, C Toumpanakis, J O'Connor, E Krenning, N Reed, D O'Toole
No abstract text is available yet for this article.
2016: Neuroendocrinology
https://www.readbyqxmd.com/read/26661066/new-feed-sources-key-to-ambitious-climate-targets
#10
Brian J Walsh, Felicjan Rydzak, Amanda Palazzo, Florian Kraxner, Mario Herrero, Peer M Schenk, Philippe Ciais, Ivan A Janssens, Josep Peñuelas, Anneliese Niederl-Schmidinger, Michael Obersteiner
Net carbon sinks capable of avoiding dangerous perturbation of the climate system and preventing ocean acidification have been identified, but they are likely to be limited by resource constraints (Nature 463:747-756, 2010). Land scarcity already creates tension between food security and bioenergy production, and this competition is likely to intensify as populations and the effects of climate change expand. Despite research into microalgae as a next-generation energy source, the land-sparing consequences of alternative sources of livestock feed have been overlooked...
December 2015: Carbon Balance and Management
https://www.readbyqxmd.com/read/26655425/bendamustine-plus-rituximab-versus-fludarabine-plus-rituximab-for-patients-with-relapsed-indolent-and-mantle-cell-lymphomas-a-multicentre-randomised-open-label-non-inferiority-phase-3-trial
#11
RANDOMIZED CONTROLLED TRIAL
Mathias Rummel, Ulrich Kaiser, Christina Balser, Martina Stauch, Wolfram Brugger, Manfred Welslau, Norbert Niederle, Christoph Losem, Hans-Peter Boeck, Eckhart Weidmann, Ulrich von Gruenhagen, Lothar Mueller, Michael Sandherr, Lars Hahn, Julia Vereshchagina, Frank Kauff, Wolfgang Blau, Axel Hinke, Juergen Barth
BACKGROUND: Fludarabine-based chemoimmunotherapy with rituximab is frequently used in patients with indolent and mantle-cell lymphomas who relapse after alkylating chemotherapy. We aimed to compare the efficacy and safety of rituximab with bendamustine or fludarabine in patients with relapsed, indolent, non-Hodgkin lymphoma and mantle-cell lymphoma. METHODS: For this randomised, non-inferiority, open-label, phase 3 trial, we recruited patients from 55 centres in Germany, who were subsequently randomised centrally according to prespecified randomisation lists with permuted blocks of randomly variable block size to rituximab (375 mg/m(2), day 1) plus either bendamustine (90 mg/m(2), days 1 and 2) or fludarabine (25 mg/m(2), days 1-3) every 28 days for a maximum of six 28-day cycles...
January 2016: Lancet Oncology
https://www.readbyqxmd.com/read/26643687/randomized-evaluation-of-the-effectiveness-of-a-structured-educational-program-for-patients-with-essential-hypertension
#12
Sabine Perl, Ella Niederl, Cornelia Kos, Peter Mrak, Herbert Ederer, Ivo Rakovac, Peter Beck, Elisabeth Kraler, Ingrid Stoff, Gert Klima, Burkert M Pieske, Thomas R Pieber, Robert Zweiker
BACKGROUND: Adherence to medication and lifestyle interventions are essential keys for the management of hypertension. In this respect, a structured educational program for hypertensive patients has got remarkable merits (herz.leben). In order to determine the isolated effect of participation in the educational program, neglecting the possible impact of more intense care, this prospective multicenter randomized controlled study was designed (NCT00453037). METHODS: A total of 256 patients in 13 centers were enrolled and randomly assigned to 2 groups (G)...
July 2016: American Journal of Hypertension
https://www.readbyqxmd.com/read/26239087/prognostic-value-of-circulating-bcl-2-igh-levels-in-patients-with-follicular-lymphoma-receiving-first-line-immunochemotherapy
#13
RANDOMIZED CONTROLLED TRIAL
Fabian Zohren, Ingmar Bruns, Sabrina Pechtel, Thomas Schroeder, Roland Fenk, Akos Czibere, Georg Maschmeyer, Dorothea Kofahl-Krause, Norbert Niederle, Gerhard Heil, Christoph Losem, Manfred Welslau, Wolfram Brugger, Ulrich Germing, Ralf Kronenwett, Juergen Barth, Mathias J Rummel, Rainer Haas, Guido Kobbe
Bcl-2/IgH rearrangements can be quantified in follicular lymphoma (FL) from peripheral blood (PB) by polymerase chain reaction (PCR). The prognostic value of Bcl-2/IgH levels in FL remains controversial. We therefore prospectively studied PB Bcl-2/IgH levels from 173 first-line FL patients who were consecutively enrolled, randomized, and treated within the multicenter phase 3 clinical trial NHL1-2003 comparing bendamustine-rituximab (B-R) with rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone...
September 17, 2015: Blood
https://www.readbyqxmd.com/read/26101370/is-surgery-necessary-for-mild-or-asymptomatic-hyperparathyroidism
#14
Bruno Niederle, Jean-Louis Wémeau
A large majority of the currently diagnosed patients with hyperparathyroidism (PHPT) are mild or asymptomatic, mainly women after menopause. Following the debate held at the 16th European Congress of Endocrinology in Wroclaw (Poland) from May 3-7, 2014, arguments are here presented by a surgeon and a medical practitioner considering these situations rather have to profit from surgery, or simply from survey. For the trained endocrine surgeon, it is evident that parathyroidectomy confirms the diagnosis and undoubtedly reduces the discomfort felt by certain patients, prevents all risks of complications, removes patients and medical teams from the monitoring and represents a real individual financial benefit...
September 2015: European Journal of Endocrinology
https://www.readbyqxmd.com/read/25817061/clinical-presentation-in-insulinoma-predicts-histopathological-tumour-characteristics
#15
Peter Wolf, Yvonne Winhofer, Sabina Smajis, Christian-Heinz Anderwald, Christian Scheuba, Bruno Niederle, Alois Gessl, Anton Luger, Michael Krebs, Oskar Koperek
BACKGROUND: Insulinomas are rare neuroendocrine tumours (NETs) of the pancreas, characterized clinically by neuroglycopenic symptoms during periods of substrate deficiency. The gold standard test for diagnosing an insulinoma is a 72-h fast. However, the prognostic value of parameters in the standardized 72-h fast on histopathological tumour criteria and clinical presentation has not been examined. METHODS: In thirty-three patients diagnosed with an insulinoma records, and data were investigated retrospectively...
July 2015: Clinical Endocrinology
https://www.readbyqxmd.com/read/25532435/postoperative-hypoparathyroidism-after-thyroidectomy-efficient-and-cost-effective-diagnosis-and-treatment
#16
Andreas Selberherr, Christian Scheuba, Philipp Riss, Bruno Niederle
BACKGROUND: To describe a standardized, efficient, and cost-effective protocol for the diagnosis of temporary/persisting postoperative hypoparathyroidism after (total) thyroidectomy. METHODS: We included 237 consecutive patients who underwent (total) thyroidectomy without central neck dissection for various indications. Serum calcium (sCa) and intact parathyroid hormone (iPTH) levels were measured prospectively on the morning of postoperative day 1 to predict the long-term parathyroid metabolism...
February 2015: Surgery
https://www.readbyqxmd.com/read/25502498/-avoidance-and-management-of-hypoparathyroidism-after-thyroid-gland-surgery
#17
REVIEW
A Selberherr, B Niederle
Postoperative hypoparathyroidism after bilateral thyroid gland surgery or after interventions for recurrence is defined as intact parathyroid hormone levels (iPTH) < 15 pg/ml with simultaneous normal, below normal and markedly decreased serum calcium levels. After bilateral thyroid surgery and after reoperations a single iPTH measurement performed 12-24 h postoperatively can be used to predict parathyroid metabolism. Patients with an iPTH level ≥ 15 pg/ml may be discharged safely, patients with an iPTH < 10 pg/ml must be substituted with calcium and vitamin D and patients with an iPTH between 10 and 15 pg/ml (grey zone) may be discharged if a second measurement 48 h after surgery documents an iPTH ≥ 15 pg/ml...
January 2015: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/25480411/morbidity-associated-with-concomitant-thyroid-surgery-in-patients-with-primary-hyperparathyroidism
#18
Philipp Riss, Michael Kammer, Andreas Selberherr, Christian Scheuba, Bruno Niederle
BACKGROUND: Recurrent laryngeal nerve (RLN) palsy and hypoparathyroidism are serious complications in thyroid and parathyroid surgery. The extent to which incidentally detected thyroid nodules should be treated concomitantly is a matter of debate. METHODS: This analysis was based on 1,065 patients who underwent consecutive surgery for primary hyperparathyroidism at a single institution. Together with the surgical strategy, histologic and follow-up examinations were documented prospectively and analyzed retrospectively regarding the occurrence and course of RLN palsy, hypoparathyroidism, and thyroid carcinoma...
August 2015: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/25421138/-treatment-of-patients-with-radioiodine-refractory-differentiated-thyroid-carcinoma-a-consensus-statement
#19
Christina Lindner, J Dierneder, G Pall, C Pirich, M Hoffmann, M Raderer, A Becherer, B Niederle, R Lipp, P Lind, H Gallowitsch, F Romeder, I Virgolini
There is no clear standard therapy for patients with radioactive iodine (131I)-refractory locally advanced or metastatic differentiated thyroid cancer. The therapeutic options for this indication have expanded with the recently approved multiple kinase inhibitor sorafenib. Recommendations for the definition and the management of iodine refractory patients were worked up by an interdisciplinary expert panel, consisting of endocrine surgeons, medical oncologists and nuclear medicine specialists.
2015: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/25296738/screening-for-medullary-carcinoma-of-the-thyroid
#20
B Niederle
No abstract text is available yet for this article.
December 2014: British Journal of Surgery
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