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Nathamon Panomuppakarn, Patamintita Witoonpanich, Jariya Waisayarat, Chuleeporn Jiarpinitnun, Touch Ativitavas, Nuttapong Ngamphaiboon
Systemic treatment of Medullary thyroid carcinoma (MTC) is currently limited to the use of a tyrosine kinase inhibitor. Cytotoxic chemotherapy is not routinely recommended in the earlier lines of treatment due to the lack of efficacy. We describe a patient with locally advanced MTC who had an uncommon response to cisplatin and etoposide.
October 2017: Clinical Case Reports
Yuki Abe, Shinya Tsukano
Medullary thyroid carcinoma (MTC) in multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant disorder caused by the mutation of the RET proto-oncogene, that shows nearly complete penetration. The American Thyroid Association guidelines recommend prophylactic thyroidectomy for patients with high-risk RET mutations. However, in Japan, ethical and medical issues may preclude prophylactic treatment in young patients. Hence, an early diagnosis of MTC is necessary to ensure a favorable outcome. Here, we report the case of a young Japanese girl with a high-risk RET mutation, diagnosed with very early stage MTC using serum calcitonin (Ctn) values measured using an electro chemiluminescence immuno-assay (ECLIA)...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
Rudolf A Werner, Jan Stefan Schmid, Takahiro Higuchi, Mehrbod Som Javadi, Steven P Rowe, Bruno Märkl, Christoph Aulmann, Martin Fassnacht, Matthias Kroiss, Christoph Reiners, Andreas K Buck, Michael Kreissl, Constantin Lapa
Introduction: Therapeutic options in advanced medullary thyroid carcinoma (MTC) have markedly improved since the introduction of tyrosine kinase inhibitors (TKI). We aimed to assess the role of metabolic imaging using 2-deoxy-2-((18)F)fluoro-D-glucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) shortly before and 3 months after initiation of TKI treatment. Methods: Eighteen patients with advanced and progressive MTC scheduled for vandetanib treatment underwent baseline (18)F-FDG PET/CT prior to and 3 months after TKI treatment initiation...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Jessica J Field, Benet Pera, Juan Estévez Gallego, Enrique Calvo, Javier Rodríguez-Salarichs, Gonzalo Sáez-Calvo, Didier Zuwerra, Michel Jordi, José M Andreu, Andrea E Prota, Grégory Ménchon, John H Miller, Karl-Heinz Altmann, J Fernando Díaz
The marine natural product zampanolide and analogues thereof constitute a new chemotype of taxoid site microtubule-stabilizing agents with a covalent mechanism of action. Zampanolide-ligated tubulin has the switch-activation loop (M-loop) in the assembly prone form and, thus, represents an assembly activated state of the protein. In this study, we have characterized the biochemical properties of the covalently modified, activated tubulin dimer, and we have determined the effect of zampanolide on tubulin association and the binding of tubulin ligands at other binding sites...
October 12, 2017: Journal of Natural Products
C Gortázar, L M Fernández-Calle, J A Collazos-Martínez, O Mínguez-González, P Acevedo
Animal tuberculosis (TB), which is caused by infection with members of the Mycobacterium tuberculosis complex (MTC), is a typical multi-host infection that flourishes at the livestock-wildlife interface. TB epidemiology is well characterized in the Mediterranean woodland habitats and Atlantic regions of southwestern Europe. However, much less is known about huge regions that do not form part of the two abovementioned settings, which have a low abundance of wild reservoirs. We hypothesized that MTC would be maintained in multi- rather than single-host communities in which wildlife would make a relatively low contribution to the maintenance of TB...
October 1, 2017: Preventive Veterinary Medicine
Ferrari Silvia Martinaa, Centanni Marco, Virili Camilla, Miccoli Mario, Ferrari Paola, Ruffilli Ilaria, Ragusa Francesca, Antonelli Alessandro, Fallahi Poupak
BACKGROUND: Sunitinib (SU11248) is an oral, small-molecule, multi-targeted tyrosine kinase inhibitor (TKI), that inhibits receptors for platelet-derived growth factor (PDGF-Rs) and vascular endothelial growth factor receptors (VEGFRs), c-KIT, fms-related tyrosine kinase 3 (FLT3) and RET. The concurrent inhibition of these pathways reduces tumor vascularization and causes cancer cell apoptosis, inducing a tumor shrinkage. Sunitinib is approved for the treatment of imatinib-resistant gastrointestinal stromal tumor (GIST), renal carcinoma, and pancreatic neuroendocrine tumors...
October 6, 2017: Current Medicinal Chemistry
Federico Caobelli, Agostino Chiaravalloti, Laura Evangelista, Giorgio Saladini, Orazio Schillaci, Manuela Vadrucci, Federica Scalorbi, Davide Donner, Pierpaolo Alongi
INTRODUCTION: Medullary thyroid carcinoma (MTC) is a malignancy accounting for about 5-8% of thyroid cancers. Serum calcitonin and carcinoembryonic antigen (CEA) levels are widely used to monitor disease progression. However, prognostic factors able to predict outcomes are highly desirable. We, therefore, aimed to assess the prognostic role of (18)F-DOPA PET/CT in patients with recurrent MTC. MATERIALS AND METHODS: 60 patients (mean age 64 ± 13 years, range 44-82) with recurrent MTC were eligible from a multicenter database...
October 6, 2017: Annals of Nuclear Medicine
Christie A Ojiaku, Gaoyuan Cao, Wanqu Zhu, Edwin J Yoo, Maya Shumyatcher, Blanca E Himes, Steven S An, Reynold A Panettieri
Transforming growth factor beta 1 (TGF-β1), a cytokine whose levels are elevated in the airways of patients with asthma, perpetuates airway inflammation and modulates airway structural cell remodeling. However, the role of TGF-β1 in excessive airway narrowing in asthma, or airway hyperresponsiveness (AHR), remains unclear. In this study, we set out to investigate the direct effects of TGF-β1 on human airway smooth muscle (HASM) cell shortening and hyperresponsiveness. The dynamics of AHR and single-cell excitation-contraction (E-C) coupling were measured in human precision-cut lung slices (hPCLS) and in isolated HASM cells using supravital microscopy and magnetic twisting cytometry (MTC), respectively...
October 6, 2017: American Journal of Respiratory Cell and Molecular Biology
Yuriko Igarashi, Kinuyo Chikamatsu, Akio Aono, Lina Yi, Hiroyuki Yamada, Akiko Takaki, Satoshi Mitarai
We evaluated the performance of two multiplex, real-time PCR tests (Anyplex II MTB/MDR and MTB/XDR; Seegene, Seoul, Korea), designed to detect the Mycobacterium tuberculosis complex (MTC) and drug-resistance mutations associated with isoniazid, rifampicin, fluoroquinolones, and second-line injectable drugs. We analyzed 122 clinical isolates with the Anyplex II MTB/MDR test, 68 of which were also tested with the Anyplex II MTB/XDR test. The Anyplex II MTB/MDR and MTB/XDR tests showed the following respective sensitivities and specificities: 68...
August 25, 2017: Diagnostic Microbiology and Infectious Disease
Eric J Kuo, Shonan Sho, Ning Li, Kyle A Zanocco, Michael W Yeh, Masha J Livhits
Importance: The association of initial neck dissection with recurrence in medullary thyroid carcinoma (MTC) has not been evaluated on a population level to date. Objective: To elucidate risk factors associated with reoperation in MTC and disease-specific mortality. Design, Setting, and Participants: A retrospective analysis was performed of hospital data obtained from the California Cancer Registry and the Office of Statewide Health Planning and Development from January 1, 1999, through December 31, 2012...
September 27, 2017: JAMA Surgery
Maria M Psiha, Panayiotis Vlamos
5G is the next generation of mobile communication technology. Current generation of wireless technologies is being evolved toward 5G for better serving end users and transforming our society. Supported by 5G cloud technology, personal devices will extend their capabilities to various applications, supporting smart life. They will have significant role in health, medical tourism, security, safety, and social life applications. The next wave of mobile communication is to mobilize and automate industries and industry processes via Machine-Type Communication (MTC) and Internet of Things (IoT)...
2017: Advances in Experimental Medicine and Biology
David F Stroncek, Bronwen E Shaw, Brent R Logan, Deidre M Kiefer, Bipin N Savani, Paolo Anderlini, Christopher N Bredeson, Peiman Hematti, Siddhartha Ganguly, Miguel Angel Diaz, Hisham Abdel-Azim, Ibrahim Ahmed, Dipnarine Maharaj, Matthew Seftel, Amer Beitinjaneh, Sachiko Seo, Jean A Yared, Joerg Halter, Paul V O'Donnell, Gregory A Hale, Zachariah Defilipp, Hillard Lazarus, Jane L Liesveld, Zheng Zhou, Pashna Munshi, Richard F Olsson, Kimberly Anne Kasow, Jeffrey Szer, Galen E Switzer, Pintip Chitphakdithai, Nirali Shah, Dennis L Confer, Michael A Pulsipher
Little is known about the experiences of individuals donating peripheral blood stem cells (PBSCs) or marrow for a second time. To study this, unrelated donors making a second donation through the National Marrow Donor Program (NMDP) between 2004 and 2013 were evaluated. Experiences of second-time donors giving marrow (n=118) (first donation was PBSC in 76; marrow in 42) were compared with those making only one marrow donation (n=5,829). Experiences of second-time donors giving PBSCs (n=602) (first donation was PBSCs in 362; marrow in 240) were compared to first-time PBSC donors (n=16,095)...
September 25, 2017: Biology of Blood and Marrow Transplantation
Seyed Ziaeddin Rasihashemi, Ramin Azhough, Ali Ramouz
INTRODUCTION: Medullary thyroid cancer (MTC) is an uncommon neoplasm originating from parafollicular C cells. Distant metastasis in MTC, such as axillary node involvement, is extremely rare. CASE REPORT: The present study describes a known case of MTC with axillary lymph node metastasis in a 31-year-old woman. In 2010, she underwent total thyroidectomy and right-sided modified radical neck dissection. In May 2015, she was referred with a 3-month history of a mass in the left axilla...
September 2017: Iranian Journal of Otorhinolaryngology
Hiroyuki Yamamoto, Jun Ishii, Tomohiro Chiba, Yoko Nakazato, Kouichi Hirano, Hiroshi Kamma
We describe a 74-year-old man with a nodular goiter accompanied by an incidental sporadic minute medullary thyroid carcinoma (MTC). Histopathologically, the MTC was a well-defined 1.7 mm tumor in the upper one-third right lobe, with solid cell nests (SCNs) adjacent to the MTC. C-cells were scattered mainly around the SCNs, but C-cell hyperplasia was not evident in the background thyroid. The MTC cell phenotype was immunohistochemically identical to background C-cells, but was completely different from the SCN main cells...
September 27, 2017: Pathology International
Katerina Saltiki, Elli Anagnostou, George Simeakis, Sofia Kouki, Anastasia Angelopoulou, Leda Sarika, Alexandra Papathoma, Maria Alevizaki
INTRODUCTION: High prevalence of RET p.Gly533Cys (c.1597G>T) has been found in familial MTC in Greece (exon8fMTC). We studied their origin and compared clinical characteristics with non-exon8-fMTC. METHODS: 102 fMTC (FMTC and MEN2A) patients (31.4% males) were followed for 2.9-37yrs (median 6yrs). 51 carried the RET exon 8 mutation; the remaining were non-exon8 fMTC (exons 10,11,13,14). RESULTS: Exon8 fMTC were older (42.3±13.3 vs 30.8±17...
September 26, 2017: Endocrine Connections
Daniel Barretto Kendler, Mario Lucio Araújo, Renata Alencar, Maria Theresa de Souza Accioly, Daniel Alves Bulzico, Cencita Cordeiro de Noronha Pessoa, Fernanda Andrade Accioly, Terence Pires de Farias, Flaia Paiva Proença Lobo Lopes, Rossana Corbo, Mario Vaisman, Fernanda Vaisman
PURPOSE: Medullary thyroid carcinoma (MTC) is a malignant neoplasm of parafollicular cells. Because it is a neuroendocrine tumor, it has known somatostatin receptors (SSTRs). The actual frequencies of the SSTR subtypes and their potential influences (by binding with endogenous somatostatin) on MTC cell proliferation have not been fully elucidated to date. The present study evaluated the occurrence of SSTR subtypes 1, 2, 3 and 5 as well as the possible role that each subtype plays in the clinical evolution of patients with MTC...
September 25, 2017: Endocrine
Maylis Lebeault, Stéphane Pinson, Marine Guillaud-Bataille, Anne-Paule Gimenez-Roqueplo, Alain Carrie, Véronique D Barbu, Pascal Pigny, Stephane Bezieau, Jean Marc Rey, Chantal Delvincourt, Sophie Giraud, Charlotte Veyrat Durebex, Patrick Saulnier, Nathalie Bouzamondo, Marie Chabbert, Julien Blin, Amira Mohamed, PAuline Romanet, Francoise Borson-Chazot, Vincent Rohmer, Anne Barlier, Mirebeau-Prunier Delphine
BACKGROUND: The presence of single nucleotide polymorphisms (SNPs) in the RET (REarranged during Transfection) gene has been investigated with regard to their potential role in the development or progression of medullary thyroid cancer (MTC) or pheochromocytomas (PHEO) in patients with the multiple endocrine neoplasia type 2 (MEN2) syndrome. The aim of this study was to evaluate the spectrum of RET variants in France between 2003 and 2013, and an evaluation of the impact of SNPs on the MEN2 A phenotype...
September 25, 2017: Thyroid: Official Journal of the American Thyroid Association
Raymond M Fertig, Adam Alperstein, Carlos Diaz, Kyle D Klingbeil, Sameera S Vangara, Ryosuke Misawa, Jennifer Reed, Sudeep Gaudi
A 41-year-old female presented with a pedunculated mass in the upper esophagus and bilateral lymphadenopathy. Biopsies suggested a neuroendocrine tumor, possibly carcinoid, and ensuing imaging revealed cervical lymph node metastases. The esophageal mass was removed endoscopically and discovered by pathologists to closely resemble medullary thyroid carcinoma (MTC) on immunohistochemistry staining. Following surgery, further work up demonstrated very high serum calcitonin levels, suggestive of medullary thyroid carcinoma, however the thyroid gland was normal on ultrasound...
August 2017: Intractable & Rare Diseases Research
Fanqian Lu, Xiaohong Chen, Yunlong Bai, Yaru Feng, Jian Wu
The present study identified the clinical features of the largest multiple endocrine neoplasia type 2 (MEN2) A pedigree from China, with a novel double missense rearranged during transfection (RET) mutation (C634Y/D707E). To the best of our knowledge, the D707E mutation has not been identified to date. In the present study, a total of 101 family members who originated from a large pedigree (134 members in total) underwent RET mutation screening by next-generation sequencing and polymerase chain reaction (PCR) amplification, followed by direct bidirectional DNA sequencing...
September 2017: Oncology Letters
Mingyuan Yang, Yuechao Zhao, Xin Yin, Ziqiang Chen, Changwei Yang, Li Li, Ming Li
STUDY DESIGN: A systematic review and meta-analysis OBJECTIVE.: To discuss the prevalence, risk factors and characteristics of the 'adding-on' phenomenon in idiopathic scoliosis (IS). SUMMARY OF BACKGROUND DATA: There are controversies on the prevalence and risk factors of the 'adding-on' phenomenon. In addition, there is no comprehensive study to describe the characteristics of 'adding-on' in IS patients. METHODS: We performed a systematic online search using PubMed, EMBASE, Web of Science, the Cochrane Library and China WeiPu Library to identify eligible studies...
September 20, 2017: Spine
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