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https://www.readbyqxmd.com/read/27907170/complementation-of-an-aglb-mutant-of-methanococcus-maripaludis-with-heterologous-oligosaccharyltransferases
#1
Yan Ding, Helen A Vrionis, James Schneider, Alison Berezuk, Cezar M Khursigara, Ken F Jarrell
The oligosaccharyltransferase is the signature enzyme for N-linked glycosylation in all domains of life. In Archaea, this enzyme termed AglB, is responsible for transferring lipid carrier-linked glycans to select asparagine residues in a variety of target proteins including archaellins, S-layer proteins and pilins. This study investigated the ability of a variety of AglBs to compensate for the oligosaccharyltransferase activity in Methanococcus maripaludis deleted for aglB, using archaellin FlaB2 as the reporter protein since all archaellins in Mc...
2016: PloS One
https://www.readbyqxmd.com/read/27904849/medullary-thyroid-carcinoma-a-30-year-experience-at-one-institution-in-korea
#2
Cho Rok Lee, Sohee Lee, Haiyoung Son, Eunjeong Ban, Sang-Wook Kang, Jandee Lee, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung, Cheong Soo Park
PURPOSE: The objective of this study was to review the clinical outcome and prognosis of patients with sporadic and hereditary medullary thyroid cancer (MTC) who were treated at a single tertiary hospital in Korea. METHODS: We retrospectively reviewed the case files of 85 patients treated from August 1982 to February 2012. RESULTS: In all, 65 patients (76.5%) had sporadic MTC and 20 patients (23.5%) had hereditary MTC. Patients in the sporadic group were older than in the hereditary group (P < 0...
December 2016: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/27900756/a-rare-case-of-medullary-carcinoma-thyroid-metastasizing-to-bilateral-breast-parenchyma
#3
Aamna Hassan, Maimoona Siddiqui, Sidra Jahangir
Medullary carcinoma of the thyroid (MTC) commonly spreads through the lymphatics to distant sites such as lung, liver and bone. Spread to the breast is rare. We report a case of metastatic MTC which progressed to develop nodal metastases to cer-vical and mediastinal regions, visceral metastases to the liver, lung and ultimately to bilateral breasts. Clinically it is important to distinguish metastatic breast lesions from primary breast cancer as each is managed differently. Both cytological and radio-logical investigations were done followed by excision biopsy...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27882277/effect-of-silver-nanoparticles-on-the-standard-soil-arthropod-folsomia-candida-collembola-and-the-eukaryote-model-organism-saccharomyces-cerevisiae
#4
Panwad Sillapawattana, Martin C H Gruhlke, Andreas Schäffer
BACKGROUND: Because of their antimicrobial properties, silver nanoparticles (AgNPs) have been widely used and have come into contact with the environment. In the present work, an effect of AgNPs on a standard soil organism, Folsomia candida, was studied (in comparison to silver nitrate) focusing on molecular and cellular alterations as ecotoxicological endpoints. RESULTS: At the molecular level, an up-regulation of metallothionein-containing protein (MTC) mRNA in AgNP-treated groups indicated toxic heavy metal stress effects caused by the release of silver ions from AgNPs, which is similar to animal groups treated with silver nitrate...
2016: Environmental Sciences Europe
https://www.readbyqxmd.com/read/27879160/development-of-mannose-anchored-thiolated-amphotericin-b-nanocarriers-for-treatment-of-visceral-leishmaniasis
#5
Gul Shahnaz, Benson J Edagwa, JoEllyn McMillan, Sohail Akhtar, Abida Raza, Naveeda A Qureshi, Masoom Yasinzai, Howard E Gendelman
AIM: Our goal was to improve treatment outcomes for visceral leishmaniasis by designing nanocarriers that improve drug biodistribution and half-life. Thus, long-acting mannose-anchored thiolated chitosan amphotericin B nanocarrier complexes (MTC AmB) were developed and characterized. MATERIALS & METHODS: A mannose-anchored thiolated chitosan nanocarrier was manufactured and characterized. MTC AmB was examined for cytotoxicity, biocompatibility, uptake and antimicrobial activities...
November 23, 2016: Nanomedicine
https://www.readbyqxmd.com/read/27876417/does-long-term-low-impact-stress-cause-population-extinction
#6
M J B Amorim, C Pereira, A M V M Soares, J J Scott-Fordsmand
This study assessed and monitored 40 consecutive reproduction tests - multigenerational (MG) - of continuous exposure to Cd (at 2 reproduction Effect Concentrations (EC): EC10 and EC50) using the standard soil invertebrate Folsomia candida, in total 3.5 years of data were collected. Endpoints included survival, reproduction, size and metallothionein (MTc) gene expression. Further, to investigate adaptation to the toxicant, additional standard toxicity experiments were performed with the MG organisms of F6, F10, F26, F34 and F40 generations of exposure...
November 19, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27873167/myocardial-perfusion-and-left-ventricular-quantitative-parameters-obtained-using-gated-myocardial-spect-comparison-of-three-software-packages
#7
Sotiria Alexiou, Panagiotis Georgoulias, George Angelidis, Varvara Valotassiou, Ioannis Tsougos, Dimitrios Psimadas, Velissarios Lakiotis, Agaristi Kaspiri, Dimitrios Alexopoulos, Dimitrios Apostolopoulos, Pavlos Vassilakos
BACKGROUND: The aim of the present study was to compare Emory Cardiac Toolbox, Myovation, and Quantitative Gated SPECT software regarding the automatic measurements of perfusion and functional left ventricular (LV) quantitative parameters, summed stress score (SSS), perfusion defect score, LV ejection fraction (LVEF), end-diastolic volume, and end-systolic volume (ESV). METHODS AND RESULTS: (99)mTc-tetrofosmin gated SPECT studies were performed in 634 consecutive patients based on the one-day stress/rest protocol...
November 21, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27872141/differential-roles-of-ret-isoforms-in-medullary-and-papillary-thyroid-carcinomas
#8
Eric Y Lian, Sarah M Maritan, Jessica G Cockburn, Katayoon Kasaian, Mathieu Jf Crupi, David Hurlbut, Steven Jones, Sam Wiseman, Lois M Mulligan
The RET receptor tyrosine kinase mediates cell proliferation, survival and migration in embryogenesis, and is implicated in transformation and tumour progression in multiple cancers. RET is frequently mutated and constitutively activated in familial and sporadic thyroid carcinomas. As a result of alternative splicing, RET is expressed as two protein isoforms, RET9 and RET51, which differ in their unique C-terminal amino acids. These isoforms have distinct intracellular trafficking and associated signaling complexes, but functional differences are not well defined...
November 21, 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27869320/molecular-epidemiology-of-hiv-1-among-the-hiv-infected-people-of-manipur-northeastern-india-emergence-of-unique-recombinant-forms
#9
Adhikarimayum Lakhikumar Sharma, Thiyam Ramsing Singh, Khuraijam Ranjana Devi, Lisam Shanjukumar Singh
According to the Joint National Programme on HIV/AIDS (UNAIDS); the northeastern region of India has the highest HIV prevalence in the country. This study was conducted to determine the current HIV-1 molecular epidemiology of Manipur, a state in northeast India. Blood samples from HIV-1 seropositive subjects were collected between June 2011 and February 2014. The partial regions of HIV-1 genes; pol and tat-vpu-env were independently amplified, sequenced, analysed and genotyped. Based on all sequences generated from 110 samples using pol and/or tat-vpu-env gene, the overall HIV-1 genotypes distribution of Manipur was as follows: 65...
November 21, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27864651/all-in-the-family-analyzing-the-impact-of-family-history-in-addition-to-genotype-on-medullary-thyroid-carcinoma-aggressiveness-in-men2a-patients
#10
Kristin L Long, Carol Etzel, Thereasa Rich, Samuel Hyde, Nancy D Perrier, Paul H Graham, Jeffrey E Lee, Mimi I Hu, Gilbert J Cote, Robert Gagel, Elizabeth G Grubbs
Several guidelines for patients with multiple endocrine neoplasia 2A (MEN2A) take into account genotype and family history of medullary thyroid carcinoma (MTC) disease aggressiveness. We sought to determine if an association exists independent of genotype, which could provide important information for counseling MEN2A patients in management of their MTC. Pedigrees of patients with ≥5 family members with MEN2A were retrospectively reviewed. Analysis was performed among kindreds with the most frequently observed codon mutation (RET 634)...
November 18, 2016: Familial Cancer
https://www.readbyqxmd.com/read/27855242/biologic-or-tofacitinib-monotherapy-for-rheumatoid-arthritis-in-people-with-traditional-disease-modifying-anti-rheumatic-drug-dmard-failure-a-cochrane-systematic-review-and-network-meta-analysis-nma
#11
REVIEW
Jasvinder A Singh, Alomgir Hossain, Elizabeth Tanjong Ghogomu, Amy S Mudano, Peter Tugwell, George A Wells
BACKGROUND: We performed a systematic review, a standard meta-analysis and network meta-analysis (NMA), which updates the 2009 Cochrane Overview, 'Biologics for rheumatoid arthritis (RA)'. This review is focused on biologic monotherapy in people with RA in whom treatment with traditional disease-modifying anti-rheumatic drugs (DMARDs) including methotrexate (MTX) had failed (MTX/other DMARD-experienced). OBJECTIVES: To assess the benefits and harms of biologic monotherapy (includes anti-tumor necrosis factor (TNF) (adalimumab, certolizumab pegol, etanercept, golimumab, infliximab) or non-TNF (abatacept, anakinra, rituximab, tocilizumab)) or tofacitinib monotherapy (oral small molecule) versus comparator (placebo or MTX/other DMARDs) in adults with RA who were MTX/other DMARD-experienced...
November 17, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27855236/vandetanib-induces-a-marked-anti-tumor-effect-and-amelioration-of-ectopic-cushing-s-syndrome-in-a-medullary-thyroid-carcinoma-patient
#12
Hashem Bseiso, Naama Lev-Cohain, David J Gross, Simona Grozinsky-Glasberg
: A 55-year-old woman diagnosed with sporadic MTC underwent total thyroidectomy 20 years ago. After the first surgery, elevated calcitonin levels in parallel with local disease persistence were noted and therefore she underwent repeated neck dissections. During follow-up, multiple foci of metastatic disease were noted in the neck and mediastinal lymph nodes, lungs and bones; however, the disease had an indolent course for a number of years, in parallel with a calcitonin doubling time of more than two years and without significant symptoms...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27853680/radiolabeled-theranostics-magnetic-and-gold-nanoparticles
#13
REVIEW
Saeideh Same, Ayuob Aghanejad, Sattar Akbari Nakhjavani, Jaleh Barar, Yadollah Omidi
Introduction: Growing advances in nanotechnology have facilitated the applications of newly emerged nanomaterials in the field of biomedical/pharmaceutical sciences. Following this trend, the multifunctional nanoparticles (NPs) play a significant role in development of advanced drug delivery systems (DDSs) such as diapeutics/theranostics used for simultaneous diagnosis and therapy. Multifunctional radiolabeled NPs with capability of detecting, visualizing and destroying diseased cells with least side effects have been considered as an emerging filed in presentation of the best choice in solving the therapeutic problems...
2016: BioImpacts: BI
https://www.readbyqxmd.com/read/27843020/is-targeted-removal-a-suitable-means-for-tuberculosis-control-in-wild-boar
#14
A Che'Amat, J A Armenteros, D González-Barrio, J F Lima, I Díez-Delgado, J A Barasona, B Romero, K P Lyashchenko, J A Ortiz, C Gortázar
We assessed the suitability of targeted removal as a means for tuberculosis (TB) control on an intensely managed Eurasian wild boar (Sus scrofa) hunting estate. The 60km(2) large study area included one capture (treatment) site, one control site, and one release site. Each site was fenced. In the summers of 2012, 2013 and 2014, 929 wild boar were live-captured on the treatment site. All wild boar were micro-chipped and tested using an animal side lateral flow test immediately after capture in order to detect antibodies to the Mycobacterium tuberculosis complex (MTC)...
November 9, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27834132/surgical-management-of-medullary-thyroid-carcinoma-in-pediatric-age
#15
Claudio Spinelli, Leonardo Rossi, Silvia Strambi, Jessica Piscioneri, Rossella Elisei, Maura Massimino, Paolo Miccoli
Medullary thyroid carcinoma (MTC) is a rare, accounting for 5% of thyroid malignancies. It is a neuroendocrine tumor wich origins from thyroid parafollicular cells. It may be sporadic, mostly in adult patients, or inherited as autosomal dominant pattern, mostly in pediatric patients. As familial cancer, MTC may presented isolated as familial medullary thyroid carcinoma (FMTC) - 10% of cases - or, most often, as part of multiple endocrine neoplasm type 2 (MEN 2A or MEN 2B) syndromes - 90% of cases. The therapy for sporadic or hereditary MTC is surgical resection and consists in total thyroidectomy associated with central compartment lymph nodal dissection; the radicality of this intervention is fundamental to obtain a definitive cure...
November 11, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27833324/hepatocellular-carcinoma-with-intra-atrial-tumor-extension-identified-on-99m-tc-labeled-macroaggregated-albumin-single-photon-emission-computed-tomography-computed-tomography
#16
Piyush Chandra, Sneha Shah, Nilendu Purandare, Archi Agrawal, Venkatesh Rangarajan
(99)mTc macroaggregated albumin (MAA) scintigraphy is always performed before administration of (90)Y--microspheres for the treatment of liver tumors for hepatopulmonary shunt calculation. Tumor thrombus visualization in the hepatic vasculature is an infrequent finding on the (99)m Tc--MAA single photon emission computed tomography. We present a rare case of a hepatocellular carcinoma extending as a tumor thrombus through hepatic vein, inferior vena cava into the right atrium.
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27833319/-99m-tc-methylene-diphosphonate-single-photon-emission-computed-tomography-computed-tomography-improves-the-diagnostic-accuracy-of-osteoid-osteoma
#17
Samuel Brian Squier, Jacob Ian Lewis, Joseph Matthew Accurso, Manoj Kumar Jain
We present a case of a 17-year-old football player who had previously received multiple facet joint injections for presumed secondary osteoarthritis. (99)mTc-methylene diphosphonate single-photon emission computed tomography/computed tomography imaging of the cervical spine demonstrated focal increased radiopharmaceutical activity in the right C2 lamina, which was associated with an osteolytic lesion with a central irregular sclerotic nidus. Surgical pathology confirmed an osteoid osteoma.
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27833313/extraosseous-99m-tc-methylene-diphosphonate-uptake-on-bone-scan-unusual-scenario
#18
Shashwat Verma, Narvesh Kumar, Subhash Chand Kheruka, Sanjay Gambhir
In nuclear medicine, (99)mTc-methylene diphosphonate. (MDP) bone scan is one of the most commonly performed procedures. MDP uptake in nonosseous tissues is occasionally found in bone scan, and the knowledge of these kinds of extraosseous uptakes is of much clinical relevance. We report here two cases where bone scan showed extraosseous MDP uptake either hepatic or splenic apart from the physiological skeletal uptake.
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27831982/comparative-effectiveness-of-treatments-for-chronic-low-back-pain-a-multiple-treatment-comparison-analysis
#19
Jeffrey A Rihn, Kristen Radcliff, Daniel C Norvell, Robert Eastlack, Frank M Phillips, Daniel Berland, Ned Sherry, Mitchell Freedman, Alexander R Vaccaro
STUDY DESIGN: A systematic review and network meta-analysis. OBJECTIVE: To determine current treatment options of chronic low back pain (LBP) as defined by randomized controlled trials (RCTs) and to compare effectiveness of those treatments using a mixed-treatment comparison (MTC). SUMMARY OF BACKGROUND DATA: It is important to provide an evidence-based assessment of the treatment options that exist for LBP. METHODS: A systematic search of RCTs was conducted in MEDLINE and the Cochrane Collaboration Library from 1990 to 2014...
November 9, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27825600/alternative-measures-of-toe-trajectory-more-accurately-predict-the-probability-of-tripping-than-minimum-toe-clearance
#20
Achu G Byju, Maury A Nussbaum, Michael L Madigan
Tripping is responsible for a large percentage of falls. Minimum toe clearance (MTC) during the swing phase of gait is commonly used to infer the probability of tripping (POT). However, there is limited empirical evidence to support the relationship between these two variables, and other measures of toe trajectory may better predict POT than MTC. The goals of this study were to: 1) quantify the relationship between MTC and POT; and 2) explore alternative measures of toe trajectory that may predict POT more accurately than MTC...
November 1, 2016: Journal of Biomechanics
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