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https://www.readbyqxmd.com/read/29471449/obesity-associated-advanced-glycation-end-products-within-the-human-uterine-cavity-adversely-impact-endometrial-function-and-embryo-implantation-competence
#1
Gabriella S Antoniotti, Melinda Coughlan, Lois A Salamonsen, Jemma Evans
STUDY QUESTION: Do obese levels of advanced glycation end products (AGEs) within the uterine cavity detrimentally alter tissue function in embryo implantation and placental development? SUMMARY ANSWER: Obese levels of AGEs activate inflammatory signaling (p65 NFκB) within endometrial epithelial cells and alter their function, cause endoplasmic reticulum (ER) stress in endometrial stromal cells and impair decidualization, compromise implantation of blastocyst mimics and inhibit trophoblast invasion...
February 20, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29468708/development-and-clinical-application-of-an-evidence-based-pharmaceutical-care-service-algorithm-in-acute-coronary-syndrome
#2
J E Kang, J M Yu, J H Choi, I-M Chung, W B Pyun, S A Kim, E K Lee, N Y Han, J-H Yoon, J M Oh, S J Rhie
WHAT IS KNOWN AND OBJECTIVE: Drug therapies are critical for preventing secondary complications in acute coronary syndrome (ACS). The purpose of this study was to develop and apply a pharmaceutical care service (PCS) algorithm for ACS and confirm that it is applicable through a prospective clinical trial. METHODS: The ACS-PCS algorithm was developed according to extant evidence-based treatment and pharmaceutical care guidelines. Quality assurance was conducted through two methods: literature comparison and expert panel evaluation...
February 21, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29455653/novel-targeted-therapies-and-immunotherapy-for-advanced-thyroid-cancers
#3
REVIEW
George E Naoum, Michael Morkos, Brian Kim, Waleed Arafat
Thyroid cancer is a frequently encountered endocrine malignancy. Despite the favorable prognosis of this disease, 15-20% of differentiated thyroid cancer (DTC) cases and most anaplastic types, remain resistant to standard treatment options, including radioactive iodine (RAI). In addition, around 30% of medullary thyroid cancer (MTC) cases show resistance after surgery. The evolving understanding of disease-specific molecular therapeutic targets has led to the approval of two targeted therapies (Sorafenib and Lenvatinib) for RAI refractory DTC and another two drugs (Vandetanib and Cabozantinib) for MTC...
February 19, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29450740/perfluorocarbon-induces-alveolar-epithelial-cell-response-through-structural-and-mechanical-remodeling
#4
Sofia André Dias, Emmanuelle Planus, Christelle Angely, Luc Lotteau, Renaud Tissier, Marcel Filoche, Bruno Louis, Gabriel Pelle, Daniel Isabey
During total liquid ventilation, lung cells are exposed to perfluorocarbon (PFC) whose chemophysical properties highly differ from standard aqueous cell feeding medium (DMEM). We herein perform a systematic study of structural and mechanical properties of A549 alveolar epithelial cells in order to characterize their response to PFC exposure, using DMEM as control condition. Changes in F-actin structure, focal adhesion density and glycocalyx distribution are evaluated by confocal fluorescent microscopy. Changes in cell mechanics and adhesion are measured by multiscale magnetic twisting cytometry (MTC)...
February 15, 2018: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29436694/lrig1-negatively-regulates-ret-mutants-and-is-downregulated-in-thyroid-cancer
#5
David Lindquist, Fernando C Alsina, Carl Herdenberg, Catharina Larsson, Jo Höppener, Na Wang, Gustavo Paratcha, Miklós Tarján, Tibor Tot, Roger Henriksson, Håkan Hedman
Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are characterized by genomic rearrangements and point mutations in the proto-oncogene RET. Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a suppressor of various receptor tyrosine kinases, including RET. LRIG1 expression levels are associated with patient survival in many cancer types. In the present study, we investigated whether the oncogenic RET mutants RET2A (C634R) and RET2B (M918T) were regulated by LRIG1, and the possible effects of LRIG1 expression in thyroid cancer were investigated in three different clinical cohorts and in a RET2B-driven mouse model of MTC...
February 9, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29429622/step-length-determines-minimum-toe-clearance-in-older-adults-and-people-with-parkinson-s-disease
#6
Lisa Alcock, Brook Galna, Ruth Perkins, Sue Lord, Lynn Rochester
Reduced foot clearance when walking may increase the risk of trips and falls in people with Parkinson's disease (PD). Changes in foot clearance in people with PD are likely to be associated with temporal-spatial characteristics of gait such as walking slowly which evokes alterations in the temporal-spatial control of stepping patterns. Enhancing our understanding of the temporal-spatial determinants of foot clearance may inform the design of falls prevention therapies. Thirty-six people with PD and 38 age-matched controls completed four intermittent walks under two conditions: self-selected and fast gait velocity...
December 13, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29427956/experimental-evidences-of-95%C3%A2-mtc-production-in-a-nuclear-reactor
#7
I M Cohen, A Robles, P Mendoza, R M Airas, E H Montoya
95 mTc has been identified as by-product in some solutions of 99 mTc obtained by irradiation of molybdenum trioxide in a reactor neutron flux. The characterization was carried out using both measurements by gamma spectrometry and half-life determination. The possible ways that lead to the 95 mTc production in a nuclear reactor are discussed.
February 2, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29408964/a-homozygous-ret-k666n-genotype-with-an-men2a-phenotype
#8
Tania Jaber, Samuel M Hyde, Gilbert J Cote, Elizabeth G Grubbs, Wesley H Giles, Cathy A Stevens, Ramona Dadu
Context: Germline RET K666N mutation has been described as a pathogenic mutation with low disease penetrance for medullary thyroid cancer (MTC) without other features of MEN2A. We describe a patient with homozygous RET K666N mutation with MTC and bilateral pheochromocytoma (PHEO). Case Description: A 59-year-old female was diagnosed with MTC after biopsy of two thyroid nodules. Coincident biochemical and radiologic testing was suspicious for bilateral PHEO, confirmed after bilateral adrenalectomy...
February 2, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29403290/apatinib-treated-advanced-medullary-thyroid-carcinoma-a-case-report
#9
Kan Chen, Yun Gao, Fei Shi, Guangqiang Cao, Jiandong Bao
Medullary thyroid carcinoma (MTC) is a rare malignancy originating from calcitonin-producing parafollicular C cells of the thyroid. Neither radiotherapy nor chemotherapy has demonstrated durable objective responses in patients with advanced MTC. Vandetanib and cabozantinib are the 2 tyrosine kinase inhibitors recently approved by the US Food and Drug Administration, which are not affordable for most Chinese patients. Herein, we report a case of an MTC patient who responded to apatinib, a Chinese homemade tyrosine kinase inhibitor-targeted vascular endothelial growth factor receptor...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29402183/temporal-trends-in-the-presentation-treatment-and-outcome-of-medullary-thyroid-carcinoma-an-israeli-multicenter-study
#10
Dania Hirsch, Orit Twito, Sigal Levy, Gideon Bachar, Eyal Robenshtok, David Gross, Haggi Mazeh, Carlos Benbassat, Simona Grozinsky-Glasberg
BACKGROUND: The widespread use of neck sonography in recent years has led to a dramatic increase in the detection of thyroid cancer, accompanied by changes in the clinicopathological features of the disease. However, small papillary carcinomas account for the bulk of this increase, while little is known about temporal changes in medullary thyroid carcinoma (MTC). The aim of this study was to evaluate trends in the presentation, treatment, and outcome of MTC. METHODS: Patients treated for MTC at four medical centers in Israel were divided into three groups by year of diagnosis: 1981-1995 (period A), 1996-2005 (period B), and 2006-2016 (period C)...
February 5, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29398672/low-dose-erythropoietin-in-patients-with-st-segment-elevation-myocardial-infarction-epo-ami-ii-%C3%A3-a-randomized-controlled-clinical-trial
#11
Tetsuo Minamino, Shuichiro Higo, Ryo Araki, Shungo Hikoso, Daisaku Nakatani, Hiroshi Suzuki, Takahisa Yamada, Masaaki Okutsu, Kouji Yamamoto, Yasushi Fujio, Yoshio Ishida, Takuya Ozawa, Kiminori Kato, Ken Toba, Yoshifusa Aizawa, Issei Komuro
BACKGROUND: Erythropoietin (EPO) has antiapoptotic and tissue-protective effects, but previous clinical studies using high-dose EPO have not shown cardioprotective effects, probably because of platelet activation and a lack of knowledge regarding the optimal dose. In contrast, a small pilot study using low-dose EPO has shown improvement in left ventricular function without adverse cardiovascular events.Methods and Results:We performed a multicenter (25 hospitals), prospective, randomized, double-blind, placebo-controlled, dose-finding study to clarify the efficacy and safety of low-dose EPO in patients with ST-segment elevation myocardial infarction (STEMI) under the Evaluation System of Investigational Medical Care of the Ministry of Health, Labor and Welfare of Japan...
February 2, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29397050/bronchoalveolar-lavage-for-diagnosis-of-tuberculosis-infection-in-elephants
#12
R Hermes, J Saragusty, I Moser, S Holtze, J Nieter, K Sachse, T Voracek, A Bernhard, T Bouts, F Göritz, T B Hildebrandt
Tuberculosis (TB) has been known to affect elephants for thousands of years. It was put into spotlight when few circus elephants were diagnosed carrying Mycobacterium (M.) tuberculosis. Because of the zoonotic risk and high susceptibility to M. tuberculosis, periodic testing was enacted since, in captive breeding programmes. Presently, trunk wash is the recommended diagnostic procedure for TB. Trunk wash, however, puts the operator at risk, has low sensitivity, and is prone to contamination. Here, bronchoalveolar lavage is described for the first time for TB diagnosis in elephants...
February 5, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29396759/multiple-endocrine-neoplasia-2-in-cyprus-evidence-for-a-founder-effect
#13
P Fanis, N Skordis, S Frangos, G Christopoulos, E Spanou-Aristidou, E Andreou, P Manoli, M Mavrommatis, S Nicolaou, M Kleanthous, M A Cariolou, V Christophidou-Anastasiadou, G A Tanteles, L A Phylactou, V Neocleous
PURPOSE: Multiple endocrine neoplasia type 2 (MEN2) affects patients with RET proto-oncogene mutations. This cohort study refers to patients who were diagnosed with familial medullary thyroid carcinoma (MTC) and underwent RET genetic testing in Cyprus between years 2002 and 2017. METHODS AND PATIENTS: Forty patients underwent RET testing by Sanger sequencing of exons 10-11 and 13-16. Genotyping with STR genetic markers flanking the RET gene along with Y-chromosome genotyping and haplogroup assignment was also performed...
February 2, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29393024/axitinib-cabozantinib-everolimus-nivolumab-sunitinib-and-best-supportive-care-in-previously-treated-renal-cell-carcinoma-a-systematic-review-and-economic-evaluation
#14
Steve J Edwards, Victoria Wakefield, Peter Cain, Charlotta Karner, Kayleigh Kew, Mariana Bacelar, Natalie Masento, Fatima Salih
BACKGROUND: Several therapies have recently been approved for use in the NHS for pretreated advanced or metastatic renal cell carcinoma (amRCC), but there is a lack of comparative evidence to guide decisions between them. OBJECTIVE: To evaluate the clinical effectiveness and cost-effectiveness of axitinib (Inlyta®, Pfizer Inc., NY, USA), cabozantinib (Cabometyx®, Ipsen, Slough, UK), everolimus (Afinitor®, Novartis, Basel, Switzerland), nivolumab (Opdivo®, Bristol-Myers Squibb, NY, USA), sunitinib (Sutent®, Pfizer, Inc...
January 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29390301/contrast-enhanced-ultrasound-diagnosis-of-hepatic-metastasis-of-concurrent-medullary-papillary-thyroid-carcinoma-a-case-report
#15
Jie Zhou, Yan Luo, Bu Yun Ma, Wen Wu Ling, Xiang Lan Zhu
RATIONALE: Co-occurrence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) in the same thyroid gland with liver metastasis is a rare condition. To our knowledge, the utility of contrast-enhanced ultrasound (CEUS) to diagnose it is much less. PATIENT CONCERNS: A 33-year-old female was referred to our hospital due to the increase in plasma calcitonin concentration and carcino-embryonic antigen 12 months after her total thyroidectomy. To find metastasis, she received laboratory tests, gray-scale US, and CEUS...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390266/pycnodysostosis-with-novel-gene-mutation-and-sporadic-medullary-thyroid-carcinoma-a-case-report
#16
Xiulin Shi, Caoxin Huang, Fangsen Xiao, Wei Liu, Jinyang Zeng, Xuejun Li
RATIONALE: Pycnodysostosis is a rare autosomal recessive skeletal dysplasia caused by a mutation in the cathepsin K encoded by cathepsin K gene (CTSK). Medullary thyroid carcinoma (MTC) is also a relatively rare type of primary thyroid carcinoma. PATIENT CONCERNS: A 31-year-old woman presenting a short stature and a palpable nodule in the front of her neck that had gradually increased in size during the last 2 years was referred to our department. She has experienced multiple fractures at lower limbs in the last 2 decades...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29390263/treatment-of-medullary-thyroid-carcinoma-with-apatinib-a-case-report-and-literature-review
#17
Sina Cai, Huan Deng, Yinkui Chen, Xing Wu, Xiaoqian Guan
RATIONALE: Medullary thyroid carcinoma (MTC) is a rare type thyroid carcinoma originating from the thyroid parafollicular cells (C cells). Chemotherapy has a limited efficacy for treating persistent or recurrent MTC. PATIENT CONCERNS: A 46-year-old woman who underwent thyroidectomy for MTC in December 2007. She began experience recurring diarrhea in January 2015 and started to cough and feel shortness of breath in March 2016. DIAGNOSES: A chestcomputed tomography (CT) scan showed metastases in the bilateral lungs, pulmonary hilum, and mediastinal lymph nodes...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29388012/large-sporadic-thyroid-medullary-carcinomas-predictive-factors-for-lymph-node-involvement
#18
Sébastien Aubert, Amandine Berdelou, Viviane Gnemmi, Hélène Behal, Robert Caiazzo, Michèle D'herbomez, Pascal Pigny, Jean Louis Wemeau, Bruno Carnaille, Florence Renaud, Brigitte Bouchindhomme, Emmanuelle Leteurtre, Michael Perrais, François Pattou, Christine Do Cao
Lymph node involvement (LNI) is one of the most important prognostic factors for poor survival in medullary thyroid carcinoma (MTC). At diagnosis, LNI is found in over 50% of sporadic MTCs, and especially in large tumours. Cervical lymph node dissection is therefore mandatory during MTC surgery. However, some large tumours (responsible for high preoperative basal calcitonin levels) are found to lack LNI, and can be cured definitely. Preoperative detection of these particular tumours might spare patients from undergoing extensive cervical dissection...
February 1, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29386230/modifying-impact-of-ret-gene-haplotypes-on-medullary-thyroid-carcinoma-clinical-course
#19
Marta Kaczmarek-Ryś, Katarzyna Ziemnicka, Andrzej Pławski, Bartlomiej Budny, Michał Michalak, Szymon Hryhorowicz, Justyna Hoppe-Gołebiewska, Pawel Borun, Monika Gołąb, Malgorzata Czetwertynska, Maria Sromek, Marlena Szalata, Marek Ruchala, Ryszard Słomski
The clinical course of medullary thyroid carcinoma (MTC) associated with the MEN2A syndrome as well as of sporadic MTC shows considerable heterogeneity. The disease picture varies between the same RET proto-oncogene mutation carriers but also among sporadic MTC patients with no RET germinal mutations, which suggests the involvement of additional modulators of the disease. However, genetic factors responsible for this heterogeneity of the MTC clinical course remain still unknown. The aim of this study was to determine if polymorphic variants or specific haplotypes of the RET gene may modify the MTC clinical course...
January 31, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29385910/design-of-mannosylated-oral-amphotericin-b-nanoformulation-efficacy-and-safety-in-visceral-leishmaniasis
#20
Hafiz Shoaib Sarwar, Muhammad Farhan Sohail, Noushin Saljoughian, Anees Ur Rehman, Sohail Akhtar, Akhtar Nadhman, Masoom Yasinzai, Howard E Gendelman, Abhay R Satoskar, Gul Shahnaz
The aim of this study was to evaluate mannose-anchored thiolated chitosan (MTC) based nanocarriers (NCs) for enhanced permeability, improved oral bioavailability and anti-parasitic potential of amphotericin B (AmB). Transgenic Leishmania donovani parasites expressing red fluorescent protein DsRed2 and imaging-flow cytometry was used to investigate parasitic burdens inside bone marrow-derived macrophages ex vivo. Cytokine estimation revealed that MTC nanocarriers activated the macrophages to impart an explicit immune response by higher production of TNF-α and IL-12 as compared to control...
January 31, 2018: Artificial Cells, Nanomedicine, and Biotechnology
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