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https://www.readbyqxmd.com/read/29228992/maccabi-proactive-telecare-center-for-chronic-conditions-the-care-of-frail-elderly-patients
#1
Avi Porath, Angela Irony, Avital Segal Borobick, Shuruk Nasser, Ateret Malachi, Naama Fund, Galit Kaufman
BACKGROUND: In 2012, Maccabi Healthcare Services founded Maccabi Telecare Center (MTC), a multi-disciplinary healthcare service providing telemedical care to complex chronic patients. The current paper describes the establishment and operation of the MTC center, from the identification of the need for the service, through the design of its solution elements, to outcomes in several areas of care. We analyze the effects of the program on elderly frail patients, a growing population with complex and costly needs...
December 11, 2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/29219214/whole-exome-sequencing-identifies-a-germline-met-mutation-in-two-siblings-with-hereditary-wild-type-ret-medullary-thyroid-cancer
#2
Marialuisa Sponziello, Silvia Benvenuti, Alessandra Gentile, Valeria Pecce, Francesca Rosignolo, Anna Rita Virzì, Melissa Milan, Paolo M Comoglio, Eric Londin, Paolo Fortina, Agnese Barnabei, Marialuisa Appetecchia, Ferdinando Marandino, Diego Russo, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti
Whole exome sequencing (WES) was used to investigate two Italian siblings with wild-type RET genotype, who developed medullary thyroid cancers (MTCs) and, later, primary prostate and breast cancers, respectively. The proband's MTC harbored a p.Met918Thr RET mutation; his sister's MTC was RET/RAS-wild-type. Both siblings had a germline mutation (p.Arg417Gln) in the extracellular Sema domain of the proto-oncogene MET. Experiments involving ectopic expression of MET p.Arg417Gln in MET-negative T47D breast cancer cells documented the mutant receptor's functionality and its ability to enhance cell migration and invasion...
December 8, 2017: Human Mutation
https://www.readbyqxmd.com/read/29206338/alphanumerical-visual-display-made-of-dna-logic-gates-for-drug-susceptibility-testing-of-pathogens
#3
Ryan Connelly, Evgeny S Morozkin, Yulia Gerasimova
Molecular diagnostics of drug resistant pathogens requires analysis of point mutations in bacterial or viral genomes, which is usually performed by trained professionals and/or by a sophisticated computer algorithm. Here, we developed a DNA-based logic system that autonomously analyzes mutations in the genome of Mycobacterium tuberculosis complex (MTC) bacterial species and communicates the output to a human user as alphanumeric characters read by the naked eye. The five-gate system displays "O" ("no infection") for the absence of MTC infection; and "P" or "F" for passing or failing a drug susceptibility test, respectively...
December 5, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29204815/sadistic-offender-or-sexual-sadism-taxometric-evidence-for-a-dimensional-structure-of-sexual-sadism
#4
Nicholas Longpré, Jean-Pierre Guay, Raymond A Knight, Massil Benbouriche
Severe sexual sadism is a disorder of sexual preferences that focuses on humiliation and domination of the victim, sometimes causing grievous injury or death. Because offenders with high levels of sadism represent a risk to both reoffend and cause considerable harm should they reoffend, a diagnosis of sexual sadism has serious implications. The actual diagnosis of sexual sadism is fraught with problems (i.e., low reliability and validity) and exhibits poor consistency across assessments and studies (Levenson, 2004; Marshall, Kennedy, & Yates, 2002a)...
December 4, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29200250/intraoperative-calcitonin-stimulation-testing-in-the-surgical-treatment-of-c-cell-disease
#5
(no author information available yet)
OBJECTIVE: The prognosis of medullary thyroid carcinoma (MTC), derived from parafollicular C-cells, depends on the completeness of the initial surgical excision. The C-cells produce calcitonin, a peptide hormone used as a biochemical and immunohistochemical tumor marker. The aim of the study was to evaluate an individualized approach to patients with C-cell disease, i.e. MTC and C-cell hyperplasia (CCH), using the intraoperative calcitonin testing-assisted surgical strategy as a predictor of the final outcome...
November 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29199249/utility-of-single-photon-emission-computed-tomography-computed-tomography-fusion-imaging-with-99-mtc-pyrophosphate-scintigraphy-in-the-assessment-of-cardiac-transthyretin-amyloidosis
#6
Noriko Tsuda, Shinya Shiraishi, Seitaro Oda, Koji Ogasawara, Fumi Sakamoto, Seiji Tomiguchi, Koichiro Fujisue, Seiji Takashio, Yasuhiro Izumiya, Kenichi Tsujita, Yukio Ando, Yasuyuki Yamashita
No abstract text is available yet for this article.
December 2, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29193888/associations-between-slower-walking-speed-and-t1%C3%AF-magnetic-resonance-imaging-of-femoral-cartilage-following-anterior-cruciate-ligament-reconstruction
#7
Steven Pfeiffer, Matthew S Harkey, Laura E Stanley, J Troy Blackburn, Darin A Padua, Jeffrey T Spang, Stephen W Marshall, Joanne M Jordan, Randy Schmitz, Daniel Nissman, Brian Pietrosimone
To determine if walking speed collected at 6 and 12 months following anterior cruciate ligament reconstruction (ACLR) associates with inter-limb differences in proteoglycan density, measured via T1ρ magnetic resonance imaging (MRI), in tibiofemoral articular cartilage 12 months following ACLR METHODS: Twenty-one individuals with a unilateral patellar-tendon autograft ACLR (10 females, 11 males, 23.9±2.7 years, 23.9±2.7 BMI) were recruited for participation in this study. Walking speed was collected using 3-dimensional motion capture at 6 and 12 months following ACLR...
November 28, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29187393/outcomes-of-children-and-adolescents-with-advanced-hereditary-medullary-thyroid-carcinoma-treated-with-vandetanib
#8
Ira Lignugaris Kraft, Srivandana Akshintala, Yuelin J Zhu, Haiyan Lei, Claudia Derse-Anthony, Eva Dombi, Seth M Steinberg, Maya Lodish, Steven Waguespack, Oxana Kapustina, Elizabeth Fox, Frank M Balis, Maria J Merino, Paul S Meltzer, John Glod, Jack F Shern, Brigitte C Widemann
PURPOSE: Vandetanib is well-tolerated in patients with advanced medullary thyroid carcinoma (MTC). Long-term outcomes and mechanisms of MTC progression have not been reported previously.  Experimental Design:We monitored toxicities and disease status in patients taking vandetanib for hereditary, advanced MTC. Tumor samples were analyzed for molecular mechanisms of disease progression. RESULTS: Seventeen patients (8 male, age 13 (9-17)* years) enrolled; 16 had a RET p...
November 29, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29170332/35%C3%A2-to-pan-scan-or-not-to-pan-scan-further-analysis-of-the-tarn-database-2012-2017
#9
Paul Hunt, Fiona Lecky, Omar Bouamra
BACKGROUND: A 'whole body' or 'pan-scan' computed tomography (CT) imaging approach is now becoming the standard of care during the early management of adult patients with suspected severe blunt multitrauma. A number of studies have variously reported a mortality benefit or no benefit from a pan-scan approach compared to that of carrying out body region-focused CT and/or plain radiographs or a mixture of imaging modalities. However, unanswered questions still remain due to the significant heterogeneity in practice between institutions, and the limitations of published studies...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29170310/13%C3%A2-prophylactic-antibiotics-for-penetrating-injury-a-review-of-practice-at-a-major-trauma-centre-literature-review-and-recommendations
#10
Marharyta Kamarova, Richard Kendall
BACKGROUND: There is a lack of clarity regarding the use of prophylactic antibiotics for patients presenting with penetrating injuries. A structured literature review and review of penetrating injury records in an MTC was undertaken with a view to help guide clinical practice. METHOD: Searches were conducted on Medline (1946-2017), Embase (1974-2017), and Cochrane (up to 2017) using key words pertaining to penetrating trauma, prophylactic antibiotics and infection...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29169190/measurement-of-basal-serum-calcitonin-for-the-diagnosis-of-medullary-thyroid-cancer
#11
Stephanie Allelein, Margret Ehlers, Corinna Morneau, Katharina Schwartz, Peter E Goretzki, Thomas Seppel, Joachim Feldkamp, Andreas Krieg, Wolfram Trudo Knoefel, Anne Kuebart, Matthias Haase, Till Dringenberg, Christine Schmid, Matthias Schott
Calcitonin (CT), a tumor marker for medullary thyroid cancer (MTC), can be stimulated with pentagastrin or calcium. Because of the unavailability of pentagastrin, basal CT measurement is frequently used for the preoperative diagnosis of MTC. The aim of the study was to define basal serum calcitonin (bCT) cut-off thresholds for diagnosing MTC. Within a retrospective analysis, 114 patients (51 males) were included fulfilling the criteria of an increased preoperative bCT level (>10 pg/ml) and the criteria of an available postoperative histology analysis...
November 23, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29142006/characterization-of-neuroendocrine-tumors-in-heterozygous-mutant-menx-rats-a-novel-model-of-invasive-medullary-thyroid-carcinoma
#12
Sara Molatore, Andrea Kügler, Martin Irmler, Tobias Wiedemann, Frauke Neff, Annette Feuchtinger, Johannes Beckers, Mercedes Robledo, Frederico Roncaroli, Natalia S Pellegata
Rats affected by the MENX syndrome spontaneously develop multiple neuroendocrine tumors (NETs) including adrenal, pituitary and thyroid gland neoplasms. MENX was initially reported to be inherited as a recessive trait and affected rats were found to be homozygous for the predisposing Cdkn1b mutation encoding p27. We here report that heterozygous MENX mutant rats (p27+/mut) develop the same spectrum of NETs seen in the homozygous (p27mut/mut) animals but with slower progression. Consequently, p27+/mut rats have a significantly shorter lifespan compared with their wild-type (p27+/+) littermates...
November 15, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29142004/advances-in-the-management-of-men2
#13
Samuel Wells
Medullary thyroid carcinoma (MTC), a tumor derived from the neural crest, occurs either sporadically or as the dominant component of the type 2 multiple endocrine neoplasia (MEN) syndromes, MEN2A and MEN2B. The discovery that mutations in the RET protooncogene cause hereditary MTC was of great importance, since it led to the development of novel methods of diagnosis and treatment. For example, the detection of a mutated RET allele in family members at risk for inheriting MEN2A or MEN2B signaled that they would develop MTC, and possibly other components of the syndromes...
November 15, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29137710/loop-mediated-isothermal-amplification-using-self-avoiding-molecular-recognition-systems-and-antarctic-thermal-sensitive-uracil-dna-glycosylase-for-detection-of-nucleic-acid-with-prevention-of-carryover-contamination
#14
Yi Wang, Dongxin Liu, Jianping Deng, Yan Wang, Jianguo Xu, Changyun Ye
Loop-mediated isothermal amplification (LAMP) is the most popular technique to amplify nucleic acid sequence without the use of temperature cycling. However, LAMP is often confounded by false-positive results, arising from interactions between (hetero-dimer) or within (self-dimerization) primers, off-target hybrids and carryover contaminants. Here, we devised a new LAMP technique that is self-avoiding molecular recognition system (SAMRS) components and antarctic thermal sensitive uracil-DNA-glycosylase (AUDG) enzyme-assisted, termed AUDG-SAMRS-LAMP...
December 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29134313/long-term-outcome-after-surgery-for-medullary-thyroid-carcinoma-a-single-center-experience
#15
Francesca Torresan, Elisabetta Cavedon, Caterina Mian, Maurizio Iacobone
BACKGROUND: Medullary thyroid carcinoma (MTC) is a rare C cells-derived tumor, with a hardly predictable long-term prognosis. This study was aimed to evaluate the predictive factors of cure and survival after surgery for MTC in a monocentric series. METHODS: A retrospective analysis of the long-term outcomes was assessed in 255 MTC patients operated between 1980 and 2015 at Padua University hospital. RESULTS: Sporadic MTC occurred in 65.1% and hereditary MTC in 34...
November 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29133048/structural-optimization-and-structure-activity-relationship-studies-of-n-phenyl-7-8-dihydro-6h-pyrimido-5-4-b-1-4-oxazin-4-amine-derivatives-as-a-new-class-of-inhibitors-of-ret-and-its-drug-resistance-mutants
#16
Jiao Yang, Kai Chen, Guo Zhang, Qiu-Yuan Yang, Yue-Shan Li, Shen-Zhen Huang, Yan-Lin Wang, Wei Yang, Xiao-Juan Jiang, Heng-Xiu Yan, Jing-Qiang Zhu, Rong Xiang, You-Fu Luo, Wei-Min Li, Yu-Quan Wei, Lin-Li Li, Sheng-Yong Yang
The RET tyrosine kinase is an important therapeutic target for medullary thyroid cancer (MTC), and drug resistance mutations of RET, particularly V804M and V804L, are a main challenge for the current targeted therapy of MTC based on RET inhibitors. In this investigation, we report the structural optimization and structure-activity relationship studies of N-phenyl-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-amine derivatives as a new class of RET inhibitors. Among all the obtained kinase inhibitors, 1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-((6,7,8,9-tetrahydropyrimido[5,4-b][1,4]oxazepin-4-yl)amino)phenyl)urea (17d) is a multi-kinase inhibitor and potently inhibits RET and its drug resistance mutants...
September 15, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29132268/simplifying-logistics-and-avoiding-the-unnecessary-in-patients-with-breast-cancer-undergoing-sentinel-node-biopsy-a-prospective-feasibility-trial-of-the-preoperative-injection-of-super-paramagnetic-iron-oxide-nanoparticles
#17
A Karakatsanis, H Olofsson, P Stålberg, L Bergkvist, S Abdsaleh, F Wärnberg
PURPOSE: Sentinel node is routinely localized with the intraoperative use of a radioactive tracer, involving challenging logistics. Super paramagnetic iron oxide nanoparticle is a non-radioactive tracer with comparable performance that could allow for preoperative localization, would simplify the procedure, and possibly be of value in axillary mapping before neoadjuvant treatment. The current trial aimed to determine the a priori hypothesis that the injection of super paramagnetic iron oxide nanoparticles in the preoperative period for the localization of the sentinel node is feasible...
November 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29126344/genetic-and-epigenetic-of-medullary-thyroid-cancer
#18
Fatemeh Khatami, Seyed Mohammad Tavangar
Medullary thyroid carcinoma (MTC) is an infrequent, calcitonin producing neuroendocrine tumor and initiates from the parafollicular C cells of the thyroid gland. Several genetic and epigenetic alterations are collaterally responsible for medullary thyroid carcinogenesis. In this review article, we shed light on all the genetic and epigenetic hallmarks of MTC. From the genetic perspective, RET, HRAS, and KRAS are the most important genes that are characterized in MTC. From the epigenetic perspective, Ras-association domain family member 1A, telomerase reverse transcriptase promoter methylations, overexpression of histone methyltransferases, EZH2 and SMYD3, and wide ranging increase and decrease in non-coding RNAs can be responsible for medullary thyroid carcinogenesis...
November 11, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/29118989/patients-with-papillary-thyroid-carcinoma-associated-with-high-stimulated-serum-calcitonin-levels
#19
Kursad Unluhizarci, Hulya Akgun, Bahadır Oz, Zuleyha Karaca, Fatih Tanriverdi, Fahrettin Kelestimur
Among various substances produced by C-cells, the most important one is calcitonin (CT) that is used for detection, post-operative follow-up and evaluation of individuals at risk of developing medullary thyroid carcinoma (MTC). However, the role of serum CT measurement in the evaluation of thyroid nodules has been widely discussed, and there is still no consensus about the role of CT in the initial evaluation of all thyroid nodules. Two patients with thyroid nodules whose fine-needle aspiration results were compatible with benign cytology besides having mildly elevated basal serum calcitonin levels were reported...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29118821/tasselnet-counting-maize-tassels-in-the-wild-via-local-counts-regression-network
#20
Hao Lu, Zhiguo Cao, Yang Xiao, Bohan Zhuang, Chunhua Shen
Background: Accurately counting maize tassels is important for monitoring the growth status of maize plants. This tedious task, however, is still mainly done by manual efforts. In the context of modern plant phenotyping, automating this task is required to meet the need of large-scale analysis of genotype and phenotype. In recent years, computer vision technologies have experienced a significant breakthrough due to the emergence of large-scale datasets and increased computational resources...
2017: Plant Methods
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