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MDRO

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https://www.readbyqxmd.com/read/29039717/high-prevalence-of-multidrug-resistant-bacteria-in-libyan-war-casualties-admitted-to-a-tertiary-care-hospital-germany
#1
Benedikt Lohr, Yvonne Pfeifer, Ursel Heudorf, Christoph Rangger, Douglas E Norris, Klaus-Peter Hunfeld
The ongoing Libyan conflict constantly causes victims among the military and civilian population. Cross-border transfer of patients represents a high risk of introducing multidrug-resistant organisms (MDROs), for example, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci, and carbapenem-resistant gram-negative organisms (CROs), into the country of destination. This study assessed the MDRO status in Libyan war casualties (n = 67) admitted to Northwest Medical Centre in Frankfurt/Main, Germany, from August 2016 till January 2017...
October 17, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29036747/prevention-of-multidrug-resistant-infections-from-contaminated-duodenoscopes-position-statement-of-the-european-society-of-gastrointestinal-endoscopy-esge-and-european-society-of-gastroenterology-nurses-and-associates-esgena
#2
Ulrike Beilenhoff, Holger Biering, Reinhard Blum, Jadranka Brljak, Monica Cimbro, Jean-Marc Dumonceau, Cesare Hassan, Michael Jung, Christiane Neumann, Michael Pietsch, Lionel Pineau, Thierry Ponchon, Stanislav Rejchrt, Jean-François Rey, Verona Schmidt, Jayne Tillett, Jeanin van Hooft
Patients should be informed about the benefits and risks of endoscopic retrograde cholangiopancreatography (ERCP)Only specially trained and competent personnel should carry out endoscope reprocessing.Manufacturers of duodenoscopes should provide detailed instructions on how to use and reprocess their equipment.In the case of modifications to their equipment, manufacturers should provide updated instructions for use.Detailed reprocessing protocols based on the manufacturer's instructions for use should clearly lay out the different reprocessing steps necessary for each endoscope model...
October 16, 2017: Endoscopy
https://www.readbyqxmd.com/read/29033075/multi-drug-resistant-organism-infections-in-a-medical-icu-association-to-clinical-features-and-impact-upon-outcome
#3
E E Magira, S Islam, M S Niederman
OBJECTIVE: To define clinical features associated with Intensive Care Unit (ICU) infections caused by multi-drug resistant organisms (MDRO) and their impact on patient outcome. DESIGN: A single-center, retrospective case-control study was carried out between January 2010 and May 2010. SETTING: A medical ICU (MICU) in the United States. PATIENTS: The study included a total of 127 MDRO-positive patients and 186 MDRO-negative patients...
October 12, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28962969/emergence-of-multi-drug-resistant-organisms-mdros-causing-fournier-s-gangrene
#4
Laura Chia, Nancy F Crum-Cianflone
BACKGROUND: Fournier's gangrene is an uncommon but often devastating infection. There are few contemporary data on the risk factors and evolving microbiologic trends including drug-resistant organisms implicated in these life-threatening infections. METHODS: A retrospective study of Fournier's gangrene from 2006 to 2015 at a large academic hospital was conducted. Cases were identified using ICD codes (ICD-9: 608.83, V13.89; ICD-10: N49.3, Z87.438), and a review of medical, radiographic, and pathology records was performed to confirm each case...
September 28, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28960264/clinical-impact-of-colonization-with-multidrug-resistant-organisms-on-outcome-after-allogeneic-stem-cell-transplantation-in-patients-with-acute-myeloid-leukemia
#5
Sebastian Scheich, Sarah Lindner, Rosalie Koenig, Claudia Reinheimer, Thomas A Wichelhaus, Michael Hogardt, Silke Besier, Volkhard A J Kempf, Johanna Kessel, Hans Martin, Anne C Wilke, Hubert Serve, Gesine Bug, Björn Steffen
BACKGROUND: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment option for patients with acute myeloid leukemia (AML). During transplantation, patients undergo a period of severe neutropenia, which puts them at high risk for infectious complications. However, the impact of patient colonization with multidrug-resistant organisms (MDRO) on overall survival remains unclear. METHODS: In this retrospective, single-center study, the authors analyzed data from 264 patients with AML who underwent a first allo-HSCT between January 2006 and March 2016 at their institution...
September 28, 2017: Cancer
https://www.readbyqxmd.com/read/28900004/network-of-microbial-and-antibiotic-interactions-drive-colonization-and-infection-with-multidrug-resistant-organisms
#6
Joyce Wang, Betsy Foxman, Lona Mody, Evan S Snitkin
The emergence and spread of multidrug-resistant organisms (MDROs) across global healthcare networks poses a serious threat to hospitalized individuals. Strategies to limit the emergence and spread of MDROs include oversight to decrease selective pressure for MDROs by promoting appropriate antibiotic use via antibiotic stewardship programs. However, restricting the use of one antibiotic often requires a compensatory increase in the use of other antibiotics, which in turn selects for the emergence of different MDRO species...
September 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28899445/microbial-disruption-indices-to-detect-colonization-with-multidrug-resistant-organisms
#7
Rafael Araos, Veronica Montgomery, Juan A Ugalde, Graham M Snyder, Erika M C D'Agata
OBJECTIVE To characterize the microbial disruption indices of hospitalized patients to predict colonization with multidrug-resistant organisms (MDROs). DESIGN A cross-sectional survey of the fecal microbiome was conducted in a tertiary referral, acute-care hospital in Boston, Massachusetts. PARTICIPANTS The study population consisted of adult patients hospitalized in general medical/surgical wards. METHODS Rectal swabs were obtained from patients within 48 hours of hospital admission and screened for MDRO colonization using conventional culture techniques...
September 13, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28870433/antibacterial-activity-of-3-3-4-trihydroxyflavone-from-justicia-wynaadensis-against-diabetic-wound-and-urinary-tract-infection
#8
Dorin Dsouza, Lakshmidevi Nanjaiah
The present investigation was designed to study the effect of an active compound isolated from Justicia wynaadensis against multi drug resistant organisms (MDRO's) associated with diabetic patients. The drug resistant pathogens implicated in wound and urinary tract infection of diabetic patients were isolated and identified by molecular sequencing. Solvent-solvent fractionation of crude methanol extract produced hexane, chloroform, ethyl acetate and methanol-water fraction, among which chloroform fraction was found to be potent when compared with other three fractions...
August 10, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28818628/a-prospective-multicentre-study-of-the-epidemiology-and-outcomes-of-bloodstream-infection-in-cirrhotic-patients
#9
M Bartoletti, M Giannella, R Lewis, P Caraceni, S Tedeschi, M Paul, C Schramm, T Bruns, M Merli, N Cobos-Trigueros, E Seminari, P Retamar, P Muñoz, M Tumbarello, P Burra, M Torrani Cerenzia, B Barsic, E Calbo, A E Maraolo, N Petrosillo, M A Galan-Ladero, G D'Offizi, N Bar Sinai, J Rodríguez-Baño, G Verucchi, M Bernardi, P Viale
OBJECTIVES: To describe the current epidemiology of bloodstream infection (BSI) in patients with cirrhosis; and to analyse predictors of 30-day mortality and risk factors for antibiotic resistance. METHODS: Cirrhotic patients developing a BSI episode were prospectively included at 19 centres in five countries from September 2014 to December 2015. The discrimination of mortality risk scores for 30-day mortality were compared by area under the receiver operator risk and Cox regression models...
August 14, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28807836/development-and-evaluation-of-the-automated-risk-assessment-system-for-multidrug-resistant-organisms-autoras-mdro
#10
E Y Hur, Y J Jin, T X Jin, S M Lee
BACKGROUND: A high proportion of infections acquired in hospitals are caused by multidrug-resistant organisms (MDROs). The priority in MDRO prevention is to detect high-risk patients and implement preventive intervention as soon as possible. AIM: To develop an automated risk assessment system for MDROs (autoRAS-MDRO) to screen for patients at MDRO infection risk and evaluate the predictive validity of the autoRAS-MDRO. METHODS: Data for 4200 variables were extracted from the electronic health records (EHRs) for constructing the MDRO risk-scoring algorithm, which was based on a logistic regression model...
August 12, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28797758/infection-control-measures-and-prevalence-of-multidrug-resistant-organisms-in-non-hospital-care-settings-in-northeastern-germany-results-from-a-one-day-point-prevalence-study
#11
N O Hübner, K Dittmann, R Begunk, A Kramer
BACKGROUND: Much of the existing literature on the epidemiology of multidrug-resistant bacterial organisms (MDROs) and infection control measures still concentrates on hospital care settings. AIM: To pilot a cross-sectional survey in long-term care facilities (LTCFs), rehabilitation clinics, and homecare services to assess the prevalence of MDROs, structural data on infection control, and referral links between care settings in the state of Mecklenburg-West Pomerania, Germany, in 2015...
August 8, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28790230/ventilator-associated-pneumonia-vap-in-a-patient-with-guillain-barre-syndrome
#12
Anti Dharmayanti, Dalima Astrawinata
A 46-year-old man was admitted to ICU with a diagnosis at the time of admission of Guillain Barre Syndrome (GBS) and sepsis due to suspected Ventilator-Associated Pneumoniae (VAP). Specimens for the following laboratory workup were inquired, i.e. complete blood count, culture and resistance workup using specimens obtained from the tip of suction pipe, urinalysis and urine culture, blood culture and resistance, procalcitonin and lactate levels. Neutrophilia was found along with increased procalcitonin and lactate levels, which supported the sepsis diagnosis...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28758615/determinants-of-implementation-of-isolation-precautions-against-infections-by-multidrug-resistant-microorganisms-a-hospital-based-multicenter-observational-study
#13
Thomas Bénet, Raphaele Girard, Solweig Gerbier-Colomban, Cédric Dananché, Elisabeth Hodille, Olivier Dauwalder, Philippe Vanhems
OBJECTIVES We aimed to ascertain the factors associated with lack of isolation precautions (IP) in patients infected or colonized by third-generation cephalosporin-resistant Enterobacteriaceae (3GCR-E) and methicillin-resistant Staphylococcus aureus (MRSA) in hospital settings. DESIGN Prospective surveillance and audit of practices. SETTING The study included 4 university hospitals in Lyon, France. PARTICIPANTS All patients hospitalized between April and June in 2013 and 2015 were included. Case patients had ≥1 clinical sample positive for MRSA and/or 3GCR-E...
October 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28722595/multidrug-resistant-microorganisms-colonizing-lower-extremity-wounds-in-patients-in-a-tertiary-care-hospital-lima-peru
#14
Rafael Mendo-Lopez, Luis Jasso, Ximena Guevara, Aurora Lizeth Astocondor, Saul Alejos, Ana C Bardossy, Tyler Prentiss, Marcus J Zervos, Jan Jacobs, Coralith García
Multidrug-resistant organism (MDRO) infections cause high morbidity and mortality, and high costs to patients and hospitals. The study aims were to determine the frequency of MDRO colonization and associated factors in patients with lower-extremity wounds with colonization. A cross-sectional study was designed during November 2015 to July 2016 in a tertiary care hospital in Lima, Peru. A wound swab was obtained for culture and susceptibility testing. MDRO colonization was defined if the culture grew with methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and/or extended spectrum beta-lactamase (ESBL) microorganisms...
June 19, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28711629/randomized-comparison-of-3-high-level-disinfection-and-sterilization-procedures-for-duodenoscopes
#15
RANDOMIZED CONTROLLED TRIAL
Graham M Snyder, Sharon B Wright, Anne Smithey, Meir Mizrahi, Michelle Sheppard, Elizabeth B Hirsch, Ram Chuttani, Riley Heroux, David S Yassa, Lovisa B Olafsdottir, Roger B Davis, Jiannis Anastasiou, Vijay Bapat, Kiran Bidari, Douglas K Pleskow, Daniel Leffler, Benjamin Lane, Alice Chen, Howard S Gold, Anthony Bartley, Aleah D King, Mandeep S Sawhney
BACKGROUND AND AIMS: Duodenoscopes have been implicated in the transmission of multidrug-resistant organisms (MDRO). We compared the frequency of duodenoscope contamination with MDRO or any other bacteria after disinfection or sterilization by 3 different methods. METHODS: We performed a single-center prospective randomized study in which duodenoscopes were randomly reprocessed by standard high-level disinfection (sHLD), double high-level disinfection (dHLD), or standard high-level disinfection followed by ethylene oxide gas sterilization (HLD/ETO)...
October 2017: Gastroenterology
https://www.readbyqxmd.com/read/28693658/patient-hand-colonization-with-mdros-is-associated-with-environmental-contamination-in-post-acute-care
#16
Payal K Patel, Julia Mantey, Lona Mody
We assessed multidrug-resistant organism (MDRO) patient hand colonization in relation to the environment in post-acute care to determine risk factors for MDRO hand colonization. Patient hand colonization was significantly associated with environmental contamination. Risk factors for hand colonization included disability, urinary catheter, recent antibiotic use, and prolonged hospital stay. Infect Control Hosp Epidemiol 2017:1-4.
July 11, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28689514/room-occupancy-associated-transmission-of-mdro-clostridium-difficile-or-norovirus-results-from-a-room-surveillance-project
#17
Sebastian Schulz-Stübner, Peter Leonards, Petra Zimmer
No abstract text is available yet for this article.
July 10, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28681083/a-novel-protocol-obviates-endoscope-sampling-for-carbapenem-resistant-enterobacteriaceae-experience-of-a-center-with-a-prior-outbreak
#18
Zachary L Smith, Arshish Dua, Kia Saeian, Nathan A Ledeboer, Mary Beth Graham, Murad Aburajab, Darren D Ballard, Abdul H Khan, Kulwinder S Dua
BACKGROUND: Numerous published outbreaks, including one from our institution, have described endoscope-associated transmission of multidrug-resistant organisms (MDROs). Individual centers have adopted their own protocols to address this issue, including endoscope culture and sequestration. Endoscope culturing has drawbacks and may allow residual bacteria, including MDROs, to go undetected after high-level disinfection. AIM: To report the outcome of our novel protocol, which does not utilize endoscope culturing, to address our outbreak...
July 5, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28651522/the-role-of-enterococcus-spp-and-multidrug-resistant-bacteria-causing-pyogenic-liver-abscesses
#19
Marcus M Mücke, Johanna Kessel, Victoria T Mücke, Katharina Schwarzkopf, Michael Hogardt, Christoph Stephan, Stefan Zeuzem, Volkhard A J Kempf, Christian M Lange
BACKGROUND: Pyogenic liver abscesses (PLA) remain a significant clinical problem. Unfortunately, little is known about current bacterial susceptibility profiles and the incidence of multidrug resistant organisms (MDROs) causing PLA in Western countries. Yet, this crucial information is pivotal to guide empirical antibiotic therapy. Aim of this study was to provide detailed characteristics of PLA with a special focus on underlying bacterial pathogens and their susceptibility to antibiotics...
June 26, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28552333/infection-trends-in-us-nursing-homes-2006-2013
#20
Carolyn T A Herzig, Andrew W Dick, Mark Sorbero, Monika Pogorzelska-Maziarz, Catherine C Cohen, Elaine L Larson, Patricia W Stone
OBJECTIVES: The objectives of this study were to estimate trends in the prevalence of infections in nursing home (NH) residents using 2006-2013 Minimum Data Set (MDS) data, estimate the number of all infections in 2013, and evaluate differences in trends between MDS versions 2.0 and 3.0. DESIGN: Retrospective study. SETTING: NHs in the United States. PARTICIPANTS: All NH residents with a quarterly or annual MDS assessment in 2006-2013 (n = 30,366,807 assessments)...
July 1, 2017: Journal of the American Medical Directors Association
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