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https://www.readbyqxmd.com/read/28180937/guidelines-for-the-management-of-postoperative-obstructive-symptoms-in-children-with-hirschsprung-disease
#1
REVIEW
J C Langer, M D Rollins, M Levitt, A Gosain, L de la Torre, R P Kapur, R A Cowles, J Horton, D H Rothstein, A M Goldstein
Although most children with Hirschsprung disease ultimately do well, many experience a variety of ongoing problems after pull-through surgery. The most common include obstructive symptoms, soiling, enterocolitis and failure to thrive. The purpose of this guideline is to present a rational approach to the management of postoperative obstructive symptoms in children with Hirschsprung disease. The American Pediatric Surgical Association Board of Governors established a Hirschsprung Disease Interest Group. Group discussions, literature review and expert consensus were then used to summarize the current state of knowledge regarding causes, methods of diagnosis, and treatment approaches to children with obstructive symptoms following pull-through for Hirschsprung disease...
February 8, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28154902/guidelines-for-the-diagnosis-and-management-of-hirschsprung-associated-enterocolitis
#2
REVIEW
Ankush Gosain, Philip K Frykman, Robert A Cowles, John Horton, Marc Levitt, David H Rothstein, Jacob C Langer, Allan M Goldstein
BACKGROUND: Patients with Hirschsprung disease are at risk for Hirschsprung-associated enterocolitis (HAEC), an inflammatory disorder of the bowel that represents the leading cause of serious morbidity and death in these patients. The diagnosis of HAEC is made based on clinical signs and symptoms which are often non-specific, making it difficult to establish a definitive diagnosis in many patients. The purpose of this guideline is to present a rational, expert-based approach to the diagnosis and management of HAEC...
February 2, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28122945/reduction-of-neonatal-mortality-requires-strengthening-of-the-health-system-a-situational-analysis-of-neonatal-care-services-in-ballabgarh
#3
Mudita Gosain, Akhil D Goel, Pradeep Kharya, Ramesh Agarwal, Ritvik Amarchand, Sanjay K Rai, Suresh Kapoor, Vinod K Paul, Anand Krishnan
BACKGROUND: Planning a comprehensive program addressing neonatal mortality will require a detailed situational analysis of available neonatal-specific health infrastructure. METHODS: We identified facilities providing essential and sick neonatal care (ENC, SNC) by a snowballing technique in Ballabgarh Block. These were assessed for infrastructure, human resource and equipment along with self-rated competency of the staff and compared with facility-based or population-based norms...
January 25, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28121886/discussion-the-drivers-of-academic-success-in-cleft-and-craniofacial-centers-a-10-year-analysis-of-over-2000-publications
#4
Sergey Y Turin, Arun K Gosain
No abstract text is available yet for this article.
February 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28092312/synchronous-presentation-of-renal-cell-carcinoma-and-hodgkin-lymphoma-in-an-adolescent
#5
Mohamed Y Elsaid, Kara G Gill, Ankush Gosain, Peter F Nichol, Charles M Leys, Darya Buehler, Catherine P Leith, Neha J Patel
BACKGROUND: Coincidence of renal cell carcinoma (RCC) and hematologic malignancies has been reported in adults but not in children. OBSERVATION: We report a case of a 16-year-old girl in whom RCC was incidentally discovered on the computed tomography scan that was performed to stage her underlying Hodgkin lymphoma. Analysis of constitutional cytogenetics for common genetic aberrations that predispose to RCC did not reveal any mutations or genetic variations. However, cytogenetics on the RCC tumor demonstrated a rare reciprocal translocation between chromosomes 6 and 11, t(6;11)(p21;q12)...
January 13, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27894915/postoperative-temporal-hollowing-is-there-a-surgical-approach-that-prevents-this-complication-a-systematic-review-and-anatomic-illustration
#6
REVIEW
Elbert E Vaca, Chad A Purnell, Arun K Gosain, Mohammed S Alghoul
BACKGROUND: Temporal hollowing is a common complication following surgical dissection in the temporal region. Our objectives were to: (1) review and clarify the temporal soft tissue relationships - supplemented by cadaveric dissection - to better understand surgical approach variations and elucidate potential etiologies of postoperative hollowing; (2) identify if there is any evidence to support a surgical approach that prevents hollowing through a systematic review. METHODS: Cadaveric dissection was performed on six hemi-heads...
November 5, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27829009/the-morphogenesis-of-cranial-sutures-in-zebrafish
#7
Jolanta M Topczewska, Ramy A Shoela, Joanna P Tomaszewski, Rupa B Mirmira, Arun K Gosain
Using morphological, histological, and TEM analyses of the cranium, we provide a detailed description of bone and suture growth in zebrafish. Based on expression patterns and localization, we identified osteoblasts at different degrees of maturation. Our data confirm that, unlike in humans, zebrafish cranial sutures maintain lifelong patency to sustain skull growth. The cranial vault develops in a coordinated manner resulting in a structure that protects the brain. The zebrafish cranial roof parallels that of higher vertebrates and contains five major bones: one pair of frontal bones, one pair of parietal bones, and the supraoccipital bone...
2016: PloS One
https://www.readbyqxmd.com/read/27804784/update-on-brazil-s-pharma-patent-landscape
#8
Rana Gosain
Brazil's Pharma market is a dynamic and promising one. It ranks within the top ten market. There are peculiar hurdles that patentees have to overcome, such as, a two-tier examination, a serious backlog at the Brazilian Patent and Trademark Office. Several measures to accelerate examination have been adopted given the meager number of Examiners.
September 2016: Pharmaceutical Patent Analyst
https://www.readbyqxmd.com/read/27728643/vanishing-lung-syndrome-a-case-report
#9
Vasudeva Naik, Shetty Shivakumar, Varun Gosain
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728123/a-study-on-the-quality-of-life-of-patients-with-type-2-diabetes-mellitus-and-hypertension
#10
Varun Gosain, Vasudeva Naik, Shetty Shivakumar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728030/candida-albicans-endocarditis-in-a-hemophiliac-patient-with-chronic-kidney-disease-a-case-report
#11
Varun Gosain, Shruthi Bettegowda
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27727783/clinical-and-neuroradiological-profile-of-patients-presenting-with-neurocysticercosis-to-a-tertiary-care-set-up-in-southern-india
#12
Varun Gosain, Vasudeva Naik, Shetty Shivakumar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27664899/multidisciplinary-approach-to-decrease-pediatric-trauma-undertriage
#13
Benjamin Eithun, Ankush Gosain
BACKGROUND: Trauma activation and/or leveling criteria are designed to balance the potential harm to individual patients from undertriage (UT) of severe injuries versus overutilization of resources from overtriage (OT) of lesser injuries. The American College of Surgeons (ACS) recommends an acceptable UT rate ≤5% and OT 25%-50%. To improve UT or OT, an intervention was performed to (1) improve accuracy in following established leveling criteria and (2) modify activation criteria in an evidence-based manner to better identify severely injured children...
October 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27556606/evaluating-the-rule-of-10s-in-cleft-lip-repair-do-data-support-dogma
#14
Ian Chow, Chad A Purnell, Philip J Hanwright, Arun K Gosain
BACKGROUND: Cleft lip represents one of the most common birth defects in the world. Although the timing of cleft lip repair is contingent on a number of factors, the "rule of 10s" remains a frequently quoted safety benchmark. Initially reported by Wilhelmsen and Musgrave in 1966 and modified by Millard in 1976, this rule referred to performing surgery once patients had reached cutoffs in weight, hemoglobin, and age/leukocyte count. Despite significant advances in both surgical and anesthetic technique, the oft-quoted "rule of 10s" has not been systematically investigated since its inception...
September 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27542645/pediatric-sarcomas
#15
REVIEW
Regan F Williams, Israel Fernandez-Pineda, Ankush Gosain
Pediatric sarcomas are a heterogeneous group of tumors accounting for approximately 10% of childhood solid tumors. Treatment is focused on multimodality therapy, which has improved the prognosis over the past two decades. Current regimens focus on decreasing treatment for low-risk patients to decrease the long-term side effects while maximizing therapy for patients with metastatic disease to improve survival. Pediatric sarcomas can be divided into soft tissue sarcomas and osseous tumors. Soft tissue sarcomas are further delineated into rhabdomyosarcomas, which affect young children and nonrhabdomyosarcomas, which are most common in adolescents...
October 2016: Surgical Clinics of North America
https://www.readbyqxmd.com/read/27348650/separation-of-craniopagus-twins-over-the-past-20-years-a-systematic-review-of-the-variables-that-lead-to-successful-separation
#16
Donald J Harvey, Ali Totonchi, Arun K Gosain
BACKGROUND: Attempted separation of craniopagus twins has continued to be associated with devastating results since the first partially successful separation with one surviving twin in 1952. To understand the factors that contribute to successful separation in the modern era of neuroimaging and modern surgical techniques, the authors reviewed and analyzed cases reported since 1995. METHODS: All reported cases of craniopagus twin separation attempts from 1995 to 2015 were identified using PubMed (n = 19)...
July 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27100852/drug-loading-of-poly-ethylene-glycol-methyl-ether-methacrylate-pegmema-based-micelles-and-mechanisms-of-uptake-in-colon-carcinoma-cells
#17
Teddy Chang, Pallavi Gosain, Martina H Stenzel, Megan S Lord
In this study polymeric micelles formed from poly(poly(ethylene glycol) methyl ether methacrylate)-block-poly(methyl methacrylate) (P(PEGMEMA75)-b-PMMA80) block copolymer of approximately 25nm in diameter were used to encapsulate the model drug, Nile Red, with a loading efficiency of 0.08wt% and a chemotherapeutic drug, doxorubicin (DOX), with an efficiency of 2.75wt%. The release of DOX from the micelles was sufficient to be cytotoxic to human colon carcinoma cells, WiDr, while Nile Red and the unloaded micelles were found not to be cytotoxic when exposed to the cells at polymer concentrations up to 200μg/mL...
August 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27020829/pediatric-surgeon-directed-wound-classification-improves-accuracy
#18
Tiffany J Zens, Deborah A Rusy, Ankush Gosain
BACKGROUND: Surgical wound classification (SWC) communicates the degree of contamination in the surgical field and is used to stratify risk of surgical site infection and compare outcomes among centers. We hypothesized that by changing from nurse-directed to surgeon-directed SWC during a structured operative debrief, we will improve accuracy of documentation. METHODS: An institutional review board-approved retrospective chart review was performed. Two time periods were defined: initially, SWC was determined and recorded by the circulating nurse (before debrief, June 2012-May 2013) and allowing 6 mo for adoption and education, we implemented a structured operative debriefing including surgeon-directed SWC (after debrief, January 2014-August 2014)...
April 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27011171/melanocytes-affect-nodal-expression-and-signaling-in-melanoma-cells-a-lesson-from-pediatric-large-congenital-melanocytic-nevi
#19
Naira V Margaryan, Alina Gilgur, Elisabeth A Seftor, Chad Purnell, Nicoleta C Arva, Arun K Gosain, Mary J C Hendrix, Luigi Strizzi
Expression of Nodal, a Transforming Growth Factor-beta (TGF-β) related growth factor, is associated with aggressive melanoma. Nodal expression in adult dysplastic nevi may predict the development of aggressive melanoma in some patients. A subset of pediatric patients diagnosed with giant or large congenital melanocytic nevi (LCMN) has shown increased risk for development of melanoma. Here, we investigate whether Nodal expression can help identify the rare cases of LCMN that develop melanoma and shed light on why the majority of these patients do not...
March 22, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26892195/aortic-and-or-mitral-valve-surgery-in-patients-with-pulmonary-hypertension-performed-via-a-minimally-invasive-approach
#20
Priyanka Gosain, Maiteder Larrauri-Reyes, Christos G Mihos, Esteban Escolar, Orlando Santana
Pulmonary hypertension (PH) in the setting of left-sided valvular heart disease is common, and significantly increases the risk of perioperative morbidity and mortality in patients undergoing aortic and/or mitral valve surgery. Minimally invasive valve surgery is associated with a decreased incidence of perioperative complications, and a faster recovery, when compared with conventional sternotomy. In the present study, the outcomes of 569 patients with PH who underwent minimally invasive aortic and/or mitral valve surgery were analysed...
May 2016: Interactive Cardiovascular and Thoracic Surgery
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