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https://www.readbyqxmd.com/read/29754878/extracorporeal-membrane-oxygenation-ecmo-risk-stratification-in-newborns-with-congenital-diaphragmatic-hernia-cdh
#1
Tim Jancelewicz, Mary E Brindle, Matthew T Harting, Elizabeth A Tolley, Max R Langham, Pamela A Lally, Ankush Gosain, Stephanie A Storgion, David W Kays
BACKGROUND: A means for early postnatal stratification of ECMO risk in CDH newborns could be used to comparatively assess the utilization and outcomes of ECMO use between centers. While multiple CDH mortality risk calculators are available, no validated tool exists specifically for prediction of ECMO use. The purpose of this study was to derive and validate an ECMO risk stratification model. METHODS: The study population was obtained from CDH Study Group registry for the period between 2007 and 2016...
April 14, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29727222/mandibular-catch-up-growth-in-pierre-robin-sequence-a-systematic-review
#2
Chad A Purnell, Lindsay E Janes, Julian L Klosowiak, Arun K Gosain
OBJECTIVE: The concept of mandibular catch-up growth is often quoted in the literature regarding Pierre Robin sequence (PRS). We endeavored to perform a systematic review of whether the literature supports this concept. DESIGN: Systematic review. INTERVENTIONS: A PubMed-based systematic review of the English literature was performed of articles objectively measuring mandibular growth or position after nonoperative management of PRS. MAIN OUTCOME MEASURES: Rate and end point of mandibular length, ramus length, gonial angle, and maxillomandibular discrepancy...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29716722/multi-view-stereo-in-the-operating-room-allows-prediction-of-healing-complications-in-a-patient-specific-model-of-reconstructive-surgery
#3
Taeksang Lee, Sergey Y Turin, Arun K Gosain, Adrian Buganza Tepole
Excessive mechanical stress leads to wound healing complications following reconstructive surgery. However, this knowledge is not easily applicable in clinical scenarios due to the difficulty in measuring stress contours during complex tissue rearrangement procedures. Computational tools have been proposed as an alternative to address this need, but obtaining patient specific geometries with an affordable and flexible setup has remained a challenge. Here we present a methodology to determine the stress contours from a reconstructive procedure on a patient-specific finite element model based on multi-view stereo (MVS)...
April 22, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29627733/improving-tissue-expansion-protocols-through-computational-modeling
#4
Taeksang Lee, Elbert E Vaca, Joanna K Ledwon, Hanah Bae, Jolanta M Topczewska, Sergey Y Turin, Ellen Kuhl, Arun K Gosain, Adrian Buganza Tepole
Tissue expansion is a common technique in reconstructive surgery used to grow skin in vivo for correction of large defects. Despite its popularity, there is a lack of quantitative understanding of how stretch leads to growth of new skin. This has resulted in several arbitrary expansion protocols that rely on the surgeon's personal training and experience rather than on accurate predictive models. For example, choosing between slow or rapid expansion, or small or large inflation volumes remains controversial...
March 29, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29580787/using-bibliometrics-to-analyze-the-state-of-academic-productivity-in-us-pediatric-surgery-training-programs
#5
Nidhi Desai, Laura V Veras, Ankush Gosain
BACKGROUND: The Accreditation Council for Graduate Medical Education (ACGME) Common Program Requirements state that faculty must establish and maintain an environment of inquiry and scholarship. Bibliometrics, the statistical analysis of written publications, assesses scientific productivity and impact. The goal of this study was to understand the state of scholarship at Pediatric Surgery training programs. METHODS: Following IRB approval, Scopus was used to generate bibliometric profiles for US Pediatric Surgery training programs and faculty...
March 5, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29573291/digital-analysis-yields-more-reliable-and-accurate-measures-of-dermal-and-epidermal-thickness-in-histologically-processed-specimens-compared-to-traditional-methods
#6
Sergey Y Turin, Joanna K Ledwon, Hanna Bae, Adrian Buganza-Tepole, Jolanta Topczewska, Arun K Gosain
Changes in the thickness of the dermis and epidermis have been described in the scenario of tissue expansion as well as inflammatory skin processes (psoriasis, contact hypersensitivity and so on). These changes have previously been quantified by using ocular micrometers to obtain and then average a limited number of spot measurements, leading to suboptimal accuracy. We describe a rapid method of using freely available Image J software to analyze digitized images of fixed skin specimens. By determining the cross-sectional area and surface length of a skin layer, a simple calculation produces more accurate and reproducible measurements of its thickness compared to historical methods, with excellent inter-rate reliability...
March 24, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29570391/deletion-of-choline-acetyltransferase-in-enteric-neurons-results-in-postnatal-intestinal-dysmotility-and-dysbiosis
#7
Carl D Johnson, Amanda J Barlow-Anacker, Joseph F Pierre, Ketrija Touw, Christopher S Erickson, John B Furness, Miles L Epstein, Ankush Gosain
Acetylcholine (ACh)-synthesizing neurons are major components of the enteric nervous system (ENS). They release ACh and peptidergic neurotransmitters onto enteric neurons and muscle. However, pharmacological interrogation has proven inadequate to demonstrate an essential role for ACh. Our objective was to determine whether elimination of ACh synthesis during embryogenesis alters prenatal viability, intestinal function, the neurotransmitter complement, and the microbiome. Conditional deletion of choline acetyltransferase ( ChAT), the ACh synthetic enzyme, in neural crest-derived neurons ( ChAT-Null) was performed...
March 23, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29554066/an-algorithm-for-airway-management-in-patients-with-pierre-robin-sequence
#8
Katherine E Hicks, Kathleen R Billings, Chad A Purnell, John M Carter, Bharat Bhushan, Arun K Gosain, Dana M Thompson, Jeffrey C Rastatter
PURPOSE: Airway management in neonates with Pierre Robin sequence (PRS) can be challenging. The goal was to describe the algorithm developed by the authors over the past 8 years. METHODS: A retrospective case series analyzing airway management in neonates with PRS admitted to the neonatal intensive care unit at a tertiary care pediatric hospital was performed. The utility of the proposed algorithm for airway management incorporating more consistent use of polysomnography (PSG), and airway assessment was assessed...
March 16, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29537880/the-greater-palatine-notch-clinical-sequelae-of-an-incomplete-greater-palatine-foramen
#9
Sergey Y Turin, Cathy J Tang, Arun K Gosain
The anatomy of the greater palatine foramen has variation with regard to location, but there have been no reports on the absence of a complete foramen. We present 2 cases of pediatric patients with cleft palates possessing a greater palatine "notch" as opposed to a bony foramen. Awareness of this anomaly is advantageous in preventing injury to the greater palatine vessels during palatoplasty.
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29533695/labial-incompetence-in-mobius-syndrome-lefort-i-impaction-case-report-and-review-of-management-strategies
#10
Elbert E Vaca, Sergey Y Turin, Arun K Gosain
Difficulty with speech intelligibility in Mobius syndrome patients due to bilabial incompetence is common yet rarely discussed. We present a patient with Mobius syndrome who underwent counterclockwise LeFort I impaction to improve her labial competence. In addition, we present a literature review of management strategies for labial incompetence correction in Mobius patients. At 7-year follow-up after LeFort 1 impaction, the patient reports improvement in speech intelligibility, specifically regarding the ability to pronounce bilabial consonants...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29490148/double-opposing-z-plasty-for-secondary-surgical-management-of-velopharyngeal-insufficiency-following-primary-furlow-palatoplasty
#11
Arun K Gosain, Harvey Chim, Walter M Sweeney
OBJECTIVE: The present study investigates the efficacy of performing a "palate rerepair" utilizing a double-opposing z-palatoplasty (DOZ) following primary Furlow palatoplasty. DESIGN: Retrospective study. SETTING: Tertiary referral academic center for craniofacial surgery. PATIENTS: 15 consecutive patients who presented with velopharyngeal insufficiency (VPI) after primary Furlow palatoplasty. MAIN OUTCOME MEASURES: All subjects were evaluated using the perceptual speech assessment (PSA) scale...
May 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29416376/treatment-and-outcomes-of-non-small-cell-lung-cancer-patients-with-high-comorbidity
#12
Jorge Rios, Rahul Gosain, Bernardo Hl Goulart, Bin Huang, Margaret N Oechsli, Jaclyn K McDowell, Quan Chen, Thomas Tucker, Goetz H Kloecker
Background: The life expectancy of untreated non-small-cell lung cancer (NSCLC) is dismal, while treatment for NSCLC improves survival. The presence of comorbidities is thought to play a significant role in the decision to treat or not treat a given patient. We aim to evaluate the association of comorbidities with the survival of patients treated for NSCLC. Methods: We performed a retrospective study of patients aged ≥66 years with invasive NSCLC between the years 2007 and 2011 in the Surveillance, Epidemiology, and End Results Kentucky Cancer Registry...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29241958/time-to-appendectomy-for-acute-appendicitis-a-systematic-review
#13
REVIEW
Danielle B Cameron, Regan Williams, Yimin Geng, Ankush Gosain, Meghan A Arnold, Yigit S Guner, Martin L Blakely, Cynthia D Downard, Adam B Goldin, Julia Grabowski, Dave R Lal, Roshni Dasgupta, Robert Baird, Robert L Gates, Julia Shelton, Tim Jancelewicz, Shawn J Rangel, Mary T Austin
OBJECTIVE: The goal of this systematic review by the American Pediatric Surgical Association Outcomes and Evidence-Based Practice Committee was to develop recommendations regarding time to appendectomy for acute appendicitis in children within the context of preventing adverse events, reducing cost, and optimizing patient/parent satisfaction. METHODS: The committee selected three questions that were addressed by searching MEDLINE, Embase, and the Cochrane Library databases for English language articles published between January 1, 1970 and November 3, 2016...
March 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29225827/gemcitabine-and-carfilzomib-induced-thrombotic-microangiopathy-eculizumab-as-a-life-saving-treatment
#14
Rahul Gosain, Amitoj Gill, Jacob Fuqua, Lesley H Volz, Mika R Kessans Knable, Ryan Bycroft, Sarah Seger, Rohit Gosain, Jorge A Rios, Ju-Hsien Chao
Drug-induced aHUS is rare; however, early diagnosis is vital to reduce morbidity and mortality. With confirmation of the diagnosis, eculizumab appears to be a viable treatment option to suppress the pro-inflammatory surge. Furthermore, adverse side effects of medications such as carfilzomib and gemcitabine should be considered in the appropriate settings.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29153467/ovarian-torsion-in-pediatric-and-adolescent-patients-a-systematic-review
#15
Roshni Dasgupta, Elizabeth Renaud, Adam B Goldin, Robert Baird, Danielle B Cameron, Meghan A Arnold, Karen A Diefenbach, Ankush Gosain, Julia Grabowski, Yigit S Guner, Tim Jancelewicz, Akemi Kawaguchi, Dave R Lal, Tolulope A Oyetunji, Robert L Ricca, Julia Shelton, Stig Somme, Regan F Williams, Cynthia D Downard
OBJECTIVE: Ovarian torsion in pediatric patients is a rare event and is primarily managed by pediatric general surgeons. Torsion can be treated with detorsion of the ovary or oopherectomy. Oopherectomy is the most common procedure performed by pediatric general surgeons for ovarian torsion. The purpose of this systematic review by the American Pediatric Surgical Association Outcomes and Evidence Based Practice Committee was to examine evidence from the medical literature and provide recommendations regarding the optimal treatment of ovarian torsion...
November 16, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29030700/pyloric-stenosis-an-enigma-more-than-a-century-after-the-first-successful-treatment
#16
REVIEW
Yousef El-Gohary, Abdelhafeez Abdelhafeez, Elizabeth Paton, Ankush Gosain, Andrew J Murphy
Despite hypertrophic pyloric stenosis (HPS) being one of the most frequently treated pediatric surgical conditions, its etiology remains incompletely understood. We review the diagnosis and treatment of this condition with an emphasis on the evolution of surgical techniques that led to laparoscopic pyloromyotomy, the most frequently performed technique for HPS today. In addition, we review key developments in the understanding of HPS etiology and treatment, including the postulated etiology of work-induced hypertrophy of the pylorus, its association with prokinetic macrolide antibiotics, and the emerging role of atropine sulfate as a medical treatment for HPS or a rescue treatment for incomplete myotomy...
January 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29028642/-lost-to-follow-up-among-adult-cancer-survivors
#17
Amitoj Gill, Rohit Gosain, Shruti Bhandari, Rahul Gosain, Gurkirat Gill, Joseph Abraham, Kenneth Miller
BACKGROUND: Follow-up cancer care is important for patients who have received IV chemotherapy but some patients discontinue their care and are lost to follow-up (LFU) at the cancer center where they were treated. The purpose of this study was to determine what proportion of cancer survivors are LFU at 5 years after treatment, the timing of LFU, and the characteristics of those who do not continue survivorship care. METHODS: Adult patients with cancer who were treated with chemotherapy at a large community teaching hospital in 2006 and 2007 were identified and linked with State tumor registry data...
October 12, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28930953/proposed-clinical-pathway-for-nonoperative-management-of-high-grade-pediatric-pancreatic-injuries-based-on-a-multicenter-analysis-a-pediatric-trauma-society-collaborative
#18
MULTICENTER STUDY
Bindi J Naik-Mathuria, Eric H Rosenfeld, Ankush Gosain, Randall Burd, Richard A Falcone, Rajan Thakkar, Barbara Gaines, David Mooney, Mauricio Escobar, Mubeen Jafri, Anthony Stallion, Denise B Klinkner, Robert Russell, Brendan Campbell, Rita V Burke, Jeffrey Upperman, David Juang, Shawn St Peter, Stephon J Fenton, Marianne Beaudin, Hale Wills, Adam Vogel, Stephanie Polites, Adam Pattyn, Christine Leeper, Laura V Veras, Ilan Maizlin, Shefali Thaker, Alexis Smith, Megan Waddell, Joseph Drews, James Gilmore, Lindsey Armstrong, Alexis Sandler, Suzanne Moody, Brandon Behrens, Laurence Carmant
BACKGROUND: Guidelines for nonoperative management (NOM) of high-grade pancreatic injuries in children have not been established, and wide practice variability exists. The purpose of this study was to evaluate common clinical strategies across multiple pediatric trauma centers to develop a consensus-based standard clinical pathway. METHODS: A multicenter, retrospective review was conducted of children with high-grade (American Association of Surgeons for Trauma grade III-V) pancreatic injuries treated with NOM between 2010 and 2015...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28893784/dual-mechanism-of-action-of-5-nitro-1-10-phenanthroline-against-mycobacterium-tuberculosis
#19
Saqib Kidwai, Chan-Yong Park, Shradha Mawatwal, Prabhakar Tiwari, Myung Geun Jung, Tannu Priya Gosain, Pradeep Kumar, David Alland, Sandeep Kumar, Avinash Bajaj, Yun-Kyung Hwang, Chang Sik Song, Rohan Dhiman, Ill Young Lee, Ramandeep Singh
New chemotherapeutic agents with novel mechanisms of action are urgently required to combat the challenge imposed by the emergence of drug-resistant mycobacteria. In this study, a phenotypic whole-cell screen identified 5-nitro-1,10-phenanthroline (5NP) as a lead compound. 5NP-resistant isolates harbored mutations that were mapped to fbiB and were also resistant to the bicyclic nitroimidazole PA-824. Mechanistic studies confirmed that 5NP is activated in an F420-dependent manner, resulting in the formation of 1,10-phenanthroline and 1,10-phenanthrolin-5-amine as major metabolites in bacteria...
November 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28841625/american-society-of-maxillofacial-surgeons-2006-to-2016-another-decade-of-excellence-in-education-and-research
#20
Gaby Doumit, Ali Totonchi, Andy Wexler, Arun K Gosain
Over the past 10 years, the American Society of Maxillofacial Surgeons (ASMS) has continued to advance to meet its mission of being the premier organization to represent maxillofacial and pediatric plastic surgery in the United States. These advances are focused on education of its members, to include the American Society of Maxillofacial Surgeons basic course, the preconference symposium, the annual meeting, two basic maxillofacial courses per year, advanced maxillofacial courses, a boot camp for craniofacial fellows, a cleft course, quarterly webinars, sponsored fellowships, a visiting professorship, and the ASMS journal...
September 2017: Plastic and Reconstructive Surgery
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