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https://www.readbyqxmd.com/read/29438510/diagnostic-accuracy-of-2-hydroxyglutarate-magnetic-resonance-spectroscopy-in-newly-diagnosed-brain-mass-and-suspected-recurrent-gliomas
#1
Min Zhou, Yue Zhou, Huijun Liao, Benjamin C Rowland, Xiangquan Kong, Nils D Arvold, David A Reardon, Patrick Y Wen, Alexander P Lin, Raymond Y Huang
Background: Isocitrate dehydrogenase (IDH) mutations result in abnormal accumulation of 2-hydroxyglutarate (2HG) in gliomas that can be detected by MRS. We examined the diagnostic accuracy of 2HG single-voxel spectroscopy (SVS) and chemical shift imaging (CSI) in both newly-diagnosed and post-treatment settings. Methods: Long-TE (97 ms) SVS and CSI were acquired in 85 subjects, including a discovery cohort of 39 patients who had postoperative residual or recurrent glioma with confirmed IDH-mutation status and 6 normal volunteers, a prospective preoperative validation cohort of 24 patients with newly-diagnosed brain mass, and a prospective recurrent-lesion validation cohort of 16 previously-treated IDH-mutant glioma patients with suspected tumor recurrence...
February 9, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29417580/in-vivo-characterization-of-brain-metabolism-by-1-h-mrs-13-c-mrs-and-18-fdg-pet-reveals-significant-glucose-oxidation-of-invasively-growing-glioma-cells
#2
Marta Lai, Irene Vassallo, Bernard Lanz, Carole Poitry-Yamate, Marie-France Hamou, Cristina Cudalbu, Rolf Gruetter, Monika E Hegi
Glioblastoma are notorious for their highly invasive growth, diffusely infiltrating adjacent brain structures that precludes complete resection, and is a major obstacle for cure. To characterize this "invisible" tumor part, we designed a high resolution multimodal imaging approach assessing in vivo the metabolism of invasively growing glioma xenografts in the mouse brain. Animals were subjected longitudinally to Magnetic Resonance Imaging (MRI) and 1 H spectroscopy (MRS) at ultra high field (14.1 Tesla) that allowed the measurement of 16 metabolic biomarkers to characterize the metabolic profiles...
February 8, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29384930/multiple-cerebral-gliomas-mimicking-central-nervous-system-inflammatory-demyelinating-diseases-a-rare-case-with-review-of-literature
#3
Yong-Jie Xiong, Xin-Ling Zhao, Xiao-Yan Wang, Deng-Ji Pan, Dai-Shi Tian
RATIONALE: Multiple cerebral gliomas (MCGs), usually classified into multifocal and multicentric subtypes, represent major diagnostic challenges as their clinical, radiologic, and pathohistological features are not uniform, often mimicking brain metastatic tumors or central nervous system inflammatory demyelinating diseases (IDD). PATIENT CONCERNS: Here, we report a rare case of MCGs with isolated seizures and 4 lesions in the brain, that was initially misdiagnosed as IDD during treatment...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29379121/a-new-method-using-raman-spectroscopy-for-in-vivo-targeted-brain-cancer-tissue-biopsy
#4
Joannie Desroches, Michael Jermyn, Michael Pinto, Fabien Picot, Marie-Andrée Tremblay, Sami Obaid, Eric Marple, Kirk Urmey, Dominique Trudel, Gilles Soulez, Marie-Christine Guiot, Brian C Wilson, Kevin Petrecca, Frédéric Leblond
Modern cancer diagnosis requires histological, molecular, and genomic tumor analyses. Tumor sampling is often achieved using a targeted needle biopsy approach. Targeting errors and cancer heterogeneity causing inaccurate sampling are important limitations of this blind technique leading to non-diagnostic or poor quality samples, and the need for repeated biopsies pose elevated patient risk. An optical technology that can analyze the molecular nature of the tissue prior to harvesting could improve cancer targeting and mitigate patient risk...
January 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29372686/proton-mr-spectroscopic-imaging-of-human-glioblastomas-at-1-5-tesla
#5
Petra Hnilicová, Romana Richterová, Ema Kantorová, Michal Bittšanský, Eva Baranovičová, Dušan Dobrota
In this study we evaluated clinical feasibility of proton magnetic resonance spectroscopy metabolite mapping (1H MRSI) by using 1.5 Tesla MR-scanner in 10 patients with high-grade glioblastoma. In vivo 1H MRSI performed with a relatively short scan time of 20 minutes enabled to obtain comprehensive information about metabolic changes in glioblastoma and adjacent tissues namely in the peritumoral edema, in the middle and solid part of the tumor, and in the normal-appearing brain tissue. Spectroscopically it was possible to identify initiation of neuronal cell death in the solid tumorous tissue via decreased N-acetyl-aspartate to creatine ratio (↓ tNAA/tCr) and expanding carcinogenesis reflected in elevated choline ratios (↑ tCho/tCr and tCho/tNAA)...
December 2017: General Physiology and Biophysics
https://www.readbyqxmd.com/read/29324911/psychological-consideration-in-patients-with-cerebral-gliomas-candidates-for-intra-operative-radiation-therapy-based-on-tumor-location
#6
Tohid Emami Meybodi, Masoumeh Najafi, Ali Keipourfard, Amir Nikouei, Afsoun Seddighi
OBJECTIVE: Intra-operative Radiation Therapy (IORT) is gaining popularity as an adjuvant option to surgical resection, in treatment of glioblastoma multiforme (GBM) for increasing survival rate, which a highly aggressive cerebral tumor with poor prognosis. Τhe authors plan to investigate the effects of IORT combined with surgical resection on the psychological status of these patients based on tumor location. SUBJECT AND METHODS: From December 2013 to February 2017, we have enrolled 109 patients with high grade cerebral gliomas, documented by Magnetic Resonance Spectroscopy (MRS)...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29320407/biodistribution-and-clearance-of-stable-superparamagnetic-maghemite-iron-oxide-nanoparticles-in-mice-following-intraperitoneal-administration
#7
Binh T T Pham, Emily K Colvin, Nguyen T H Pham, Byung J Kim, Emily S Fuller, Elizabeth A Moon, Raphael Barbey, Samuel Yuen, Barry H Rickman, Nicole S Bryce, Stephanie Bickley, Marcel Tanudji, Stephen K Jones, Viive M Howell, Brian S Hawkett
Nanomedicine is an emerging field with great potential in disease theranostics. We generated sterically stabilized superparamagnetic iron oxide nanoparticles (s-SPIONs) with average core diameters of 10 and 25 nm and determined the in vivo biodistribution and clearance profiles. Healthy nude mice underwent an intraperitoneal injection of these s-SPIONs at a dose of 90 mg Fe/kg body weight. Tissue iron biodistribution was monitored by atomic absorption spectroscopy and Prussian blue staining. Histopathological examination was performed to assess tissue toxicity...
January 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29315660/precision-and-bias-of-target-controlled-prolonged-propofol-infusion-for-general-anesthesia-and-sedation-in-neurosurgical-patients
#8
Andrea Cortegiani, Alessandra Pavan, Fabio Azzeri, Giuseppe Accurso, Filippo Vitale, Cesare Gregoretti
The aim of this study was to determine the relationship, precision, and bias of a propofol target-controlled infusion (TCI) system during prolonged infusion in neurosurgical patients. We retrospectively included patients undergoing general anesthesia for elective neurosurgical removal of brain tumors and postoperative sedation in the intensive care unit over a period of 3 months. TCI of propofol (Diprifusor - Marsh model) and remifentanil were used for general anesthesia and sedation. We compared propofol blood concentration (Cmeas ) measured by liquid chromatography-mass spectroscopy with predicted concentrations (Cpred ) by the TCI system at 40 minutes (T0), 2 hours (T1), and 4 hours (T2) and every 8 hours after starting the drug infusion and at the time of emergence from sedation...
January 9, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29312599/histopathological-molecular-clinical-and-radiological-characterization-of-rosette-forming-glioneuronal-tumor-in-the-central-nervous-system
#9
Chenlong Yang, Jingyi Fang, Guang Li, Shaowu Li, Tingting Ha, Jiangfei Wang, Bao Yang, Jun Yang, Yulun Xu
Objective: A rosette-forming glioneuronal tumor (RGNT) is a rare entity originally described in the fourth ventricle. Recently, RGNTs occurring in extraventricular sites and those with malignant behaviors have been reported. The purpose of this study was to analyze the clinicoradiological and histopathological features, therapeutic strategies, and outcomes of RGNTs. Methods: We enrolled 38 patients diagnosed with RGNTs pathologically between August 2009 and June 2016...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29287025/2-hydroxyglutarate-detection-by-short-echo-time-magnetic-resonance-spectroscopy-in-routine-imaging-study-of-brain-glioma-at-3-0-t
#10
Girolamo Crisi, Silvano Filice, Maria Michiara, Pellegrino Crafa, Silvia Lana
OBJECTIVE: The objective of this study was to assess the effective performance of short echo time magnetic resonance spectroscopy (short TE MRS) for 2HG detection as biomarker of isocitrate dehydrogenase (IDH) status in all grade glioma (GL). METHODS: A total of 82 GL patients were prospectively investigated by short TEMRS at 3.0 T as part of a multimodal magnetic resonance imaging study protocol. Spectral analysis was performed using linear combination model. Tumor specimens were diagnosed as IDH mutant or wild type according to the 2016 World Health Organization (WHO) classification of brain tumors...
December 28, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29259030/optical-analysis-of-glioma-fourier-transform-infrared-spectroscopy-reveals-the-idh1-mutation-status
#11
Ortrud Uckermann, Tareq A Juratli, Roberta Galli, Marina Conde, Ralf Wiedemuth, Dietmar Krex, Kathrin D Geiger, Achim Temme, Gabriele Schackert, Edmund Koch, Gerald Steiner, Matthias Kirsch
PURPOSE: Somatic mutations in human cytosolic isocitrate dehydrogenase 1 (IDH1) gene cause profound changes in cell metabolism and are a common feature of gliomas with unprecedented predictive and prognostic impact. Fourier-transform infrared (FT-IR) spectroscopy addresses the molecular composition of cells and tissue and was investigated to deduct the IDH1-mutation status. EXPERIMENTAL DESIGN: We tested the technique on human cell lines that were transduced with IDH1 wild-type or mutated IDH1 and on 34 human glioma samples...
December 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29204309/laser-application-in-neurosurgery
#12
REVIEW
Evgenii Belykh, Kaan Yagmurlu, Nikolay L Martirosyan, Ting Lei, Mohammadhassan Izadyyazdanabadi, Kashif M Malik, Vadim A Byvaltsev, Peter Nakaji, Mark C Preul
Background: Technological innovations based on light amplification created by stimulated emission of radiation (LASER) have been used extensively in the field of neurosurgery. Methods: We reviewed the medical literature to identify current laser-based technological applications for surgical, diagnostic, and therapeutic uses in neurosurgery. Results: Surgical applications of laser technology reported in the literature include percutaneous laser ablation of brain tissue, the use of surgical lasers in open and endoscopic cranial surgeries, laser-assisted microanastomosis, and photodynamic therapy for brain tumors...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29193406/online-1-h-mrs-measurements-of-time-varying-lactate-production-in-an-animal-model-of-glioma-during-administration-of-an-anti-tumoral-drug
#13
Yannick Crémillieux, Roberto Salvati, Ursule Dumont, Noël Pinaud, Véronique Bouchaud, Stéphane Sanchez, Stefan Glöggler, Alan Wong
The aims of this study were to implement a magnetic resonance spectroscopy (MRS) protocol for the online profiling of subnanomolar quantities of metabolites sampled from the extracellular fluid using implanted microdialysis and to apply this protocol in glioma-bearing rats for the quantification of lactate concentration and the measurement of time-varying lactate concentration during drug administration. MRS acquisitions on the brain microdialysate were performed using a home-built, proton-tuned, microsolenoid with an active volume of 2 μL...
November 29, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29154228/practical-prognostic-score-for-predicting-the-extent-of-resection-and-neurological-outcome-of-gliomas-in-the-sensorimotor-area
#14
Giannantonio Spena, Federico D'Agata, Pier Paolo Panciani, Luciano Buttolo, Michela Buglione di Monale Bastia, Marco Maria Fontanella
OBJECTIVE: In this prospective study, we assessed the utility of a novel prognostic score (PS) in guiding the surgical strategy of patients with sensorimotor area gliomas. PATIENTS AND METHODS: Form December 2012 to April 2016, we collected data from patients diagnosed with brain gliomas in the sensorimotor area. All the patients had intraoperatively confirmed contiguity or continuity with sensorimotor cortical and subcortical structures. Several clinical and radiological factors were analyzed to generate a PS for each patient (range 1-8)...
November 16, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29143277/myo-inositol-concentration-in-mr-spectroscopy-for-differentiating-high-grade-glioma-from-primary-central-nervous-system-lymphoma
#15
Hiroaki Nagashima, Takashi Sasayama, Kazuhiro Tanaka, Katsusuke Kyotani, Naoko Sato, Masahiro Maeyama, Masaaki Kohta, Junichi Sakata, Yusuke Yamamoto, Kohkichi Hosoda, Tomoo Itoh, Ryohei Sasaki, Eiji Kohmura
It is sometimes difficult to distinguish gliomas from other tumors on routine imaging. In this study, we assessed whether 3-T magnetic resonance spectroscopy (MRS) with LCModel software might be useful for discriminating glioma from other brain tumors, such as primary central nervous system lymphomas (PCNSLs) and metastatic tumors. A total of 104 cases of brain tumor (66 gliomas, 20 PCNSLs, 6 metastatic tumors, 12 other tumors) were preoperatively investigated with short echo time (35 ms) single-voxel 3-T MRS...
November 15, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29143062/-intracranial-cystic-lesions
#16
REVIEW
F Ahlhelm, K Shariat, S Götschi, S Ulmer
CLINICAL PROBLEM: Intracerebral cysts are common findings in imaging of the neurocranium and are not always clinically significant. The pathological spectrum of intracerebral cysts is, however, very broad and in addition to incidental findings includes developmental disorders, malformation tumors, primary and secondary neoplasms and infectious etiologies, such as cerebral abscess formation, cysticercosis or residuals after congenital cytomegalovirus infections. Intracerebral cystic defects may be caused by inflammatory central nervous system (CNS) diseases, such as multiple sclerosis as well as by mitochondriopathies, leukodystrophy, electrolyte disturbances or osmotic demyelination syndrome or brain infarctions, e...
November 15, 2017: Der Radiologe
https://www.readbyqxmd.com/read/29106741/development-and-characterization-of-a-handheld-hyperspectral-raman-imaging-probe-system-for-molecular-characterization-of-tissue-on-mesoscopic-scales
#17
Karl St-Arnaud, Kelly Aubertin, Mathias Strupler, Wendy-Julie Madore, Andrée-Anne Grosset, Kevin Petrecca, Dominique Trudel, Frédéric Leblond
PURPOSE: Raman spectroscopy is a promising cancer detection technique for surgical guidance applications. It can provide quantitative information relating to global tissue properties associated with structural, metabolic, immunological and genetic biochemical phenomena in terms of molecular species including amino acids, lipids, proteins, and nucleic acid (DNA). To date in vivo Raman spectroscopy systems mostly included probes and biopsy needles typically limited to single-point tissue interrogation over a scale between 100 and 500 microns...
November 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28989830/combining-magnetic-resonance-spectroscopy-and-magnetic-resonance-imaging-in-diagnosing-focal-brain-lesions-in-children
#18
Farah Naz, Waseem A Mirza, Nauman Hashmani
Introduction We attempted to find the sensitivity and specificity of various pediatric brain masses in the Pakistani population while keeping histopathology or clinical diagnosis as the gold standard.   Methods This was a retrospective study that was conducted from January 2007 to January 2016. We reviewed the records of 204 patients that presented to the radiology department of Aga Khan University Hospital (AKUH). Out of the 204, 135 pediatric patients in the 0-18 age group with focal brain lesions who underwent magnetic resonance spectroscopy (MRS) and a biopsy or clinical diagnosis were included...
August 4, 2017: Curēus
https://www.readbyqxmd.com/read/28987196/overview-of-neuroradiology
#19
Elna-Marie Larsson, Johan Wikström
Neuroradiology with computed tomography (CT) and magnetic resonance imaging (MRI) is essential for the initial evaluation of patients with a clinical suspicion of brain and spine disorders. Morphologic imaging is required to obtain a probable diagnosis to support the treatment decisions in pre- and perinatal disorders, vascular diseases, traumatic injuries, metabolic disorders, epilepsy, infection/inflammation, neurodegenerative disorders, degenerative spinal disease, and tumors of the central nervous system...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28936429/clinical-pet-mri-in-neurooncology-opportunities-and-challenges-from-a-single-institution-perspective
#20
REVIEW
Lisbeth Marner, Otto M Henriksen, Michael Lundemann, Vibeke Andrée Larsen, Ian Law
PURPOSE: Magnetic resonance imaging (MRI) plays a key role in neurooncology, i.e., for diagnosis, treatment evaluation and detection of recurrence. However, standard MRI cannot always separate malignant tissue from other pathologies or treatment-induced changes. Advanced MRI techniques such as diffusion-weighted imaging, perfusion imaging and spectroscopy show promising results in discriminating malignant from benign lesions. Further, supplemental imaging with amino acid positron emission tomography (PET) has been shown to increase accuracy significantly and is used routinely at an increasing number of sites...
2017: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
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