Junyu Zhu, Lili Li, Joanna Tong, Connie Hui, Chi Hang Wong, Kwok Wai Lo, Raymond Chan, Qi Yong Ai, Edwin P Hui, Anthony Tc Chan, Ka F To, Qian Tao, Brigette By Ma
Aberrant epigenetic regulation is critically involved in the pathogenesis of nasopharyngeal carcinoma (NPC), where abnormal histone methylation can be found in polycomb repressive complex-2 (PRC2) related cancer gene loci. This study investigated some novel combinational strategies against NPC in vitro using PRC2-targeting agents as a backbone. PRC2 subunit proteins were overexpressed in over 70% of NPC tumors and enhancer of zeste homolog-2 (EZH2) expression correlated with more advanced T-stage. Basal expression of EZH2 and embryonic ectoderm development (EED) was higher in Epstein-Bar virus (EBV)+ NPC cells than EBV- cells...
2020: American Journal of Cancer Research