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https://www.readbyqxmd.com/read/28750506/microbial-communities-and-physicochemical-properties-of-myeolchi-jeotgal-anchovy-jeotgal-prepared-with-different-types-of-salts
#1
Jae Min Shim, Kang Wook Lee, Zhuang Yao, Jeong A Kim, Hyun-Jin Kim, Jeong Hwan Kim
Myeolchi jeotgals (MJs) were prepared with purified salt (PS), solar salt aged for 1 year (SS), and bamboo salt melted 3 times (BS) at 10% and 20% (w/w) concentrations, and fermented for 28 weeks at 15°C. BS MJ showed higher pH, lower titratable acidities than other samples because of alkalinity of bamboo salt. Lactic acid bacteria (LAB) counts increased until 4-6 weeks and then decreased gradually, and not detected after 20 weeks from MJs with 10% salt. Yeast counts of PS MJs were higher than those of BS and SS MJs...
July 31, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28750501/the-current-management-of-kidney-disease-in-the-elderly
#2
Agnieszka Perkowska-Ptasinska, Dominika Deborska-Materkowska, Magdalena Durlik
CKD, diabetes and cardiovascular disease constitute three interrelated conditions of strong public health relevance. Elderly individuals account for the largest and the most rapidly growing age segment of the ESRD population. The elderly are affected by the same types of kidney diseases as younger individuals, but aging itself is associated with a gradual reduction in eGFR, which leads to the diminishment of the functional reserve and makes an individual more vulnerable to injurious effects of hypertension, cardiovascular disease, diabetes, and drugs' toxicity...
July 27, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28750487/the-effect-of-intragastric-administration-of-botulinum-toxin-type-a-on-reducing-adiposity-in-a-rat-model-of-obesity-using-micro-ct-and-histological-examinations
#3
Jin-Seok Park, Hong-Mei Zheng, Jae-Min Kim, Chung Sei Kim, Seok Jeong, Don Haeng Lee
Background/Aims: Botulinum toxin type A (BTX), a long-acting inhibitor of muscular contraction in both striated and smooth muscles, is responsible for gastric motility. The aim of this study was to investigate the effects of an endoscopic intragastric BTX injection on weight loss, body fat accumulation, and gastric emptying time. Methods: The BTX group consisted of 15 obese rats in which 20 U of BTX were injected into the gastric antrum. The saline group consisted of 15 obese rats injected with 20 U of saline, and the control group included 10 obese rats that did not receive a surgical intervention...
July 28, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28750483/advanced-colonic-neoplasia-at-follow-up-colonoscopy-according-to-risk-components-and-adenoma-location-at-index-colonoscopy-a-retrospective-study-of-1-974-asymptomatic-koreans
#4
Su Jung Baik, Hyojin Park, Jae Jun Park, Hyun Ju Lee, So Young Jo, Yoo Mi Park, Hye Sun Lee
Background/Aims: We aimed to estimate the cumulative incidence of advanced colonic neoplasia and analyze the risk factors for advanced colonic neoplasia according to risk components and adenoma location at index colonoscopy. Methods: We reviewed 1,974 subjects who underwent a follow-up colonoscopy after a complete screening colonoscopy and the removal of all polyps. We estimated the cumulative incidence of a subsequent advanced neoplasia according to risk groups (normal, low-risk, and high-risk)...
July 28, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28750481/aqueous-shunts-for-glaucoma
#5
REVIEW
Victoria L Tseng, Anne L Coleman, Melinda Y Chang, Joseph Caprioli
BACKGROUND: Aqueous shunts are employed to control intraocular pressure (IOP) for people with primary or secondary glaucomas who fail or are not candidates for standard surgery. OBJECTIVES: To assess the effectiveness and safety of aqueous shunts for reducing IOP in glaucoma compared with standard surgery, another type of aqueous shunt, or modification to the aqueous shunt procedure. SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register) (2016, Issue 8), MEDLINE Ovid (1946 to August 2016), Embase...
July 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28750477/anti-pcsk9-antibodies-for-hypercholesterolaemia-overview-of-clinical-data-and-implications-for-primary-care
#6
REVIEW
Olivier S Descamps, Uwe Fraass, Ricardo Dent, Winfried März, Ioanna Gouni-Berthold
OBJECTIVES: To put data from our recent systematic review of phase 3 studies of anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) antibodies into the context of clinical practice. METHODS: Data from studies previously identified by a systematic review of phase 3 studies of alirocumab and evolocumab and additional references from non-systematic literature searches were used. We evaluated the hypothetical cardiovascular (CV) benefit in cases of typical patients in whom anti-PCSK9 antibodies may be recommended, using preliminary major CV event (CVE) rates from long-term clinical trials of anti-PCSK9 antibodies and from extrapolations derived from correlation between low-density lipoprotein cholesterol (LDL-C) reduction and CV benefit with other lipid-lowering therapies (LLTs)...
July 27, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28750433/effect-of-a-12-week-aerobic-exercise-training-on-serum-fetuin-a-and-adipocytokine-levels-in-type-2-diabetes
#7
Ling-Yun Zhang, Tao Liu, Ya-Qin Teng, Xiao-Yan Yao, Tian-Tian Zhao, Liang-Yan Lin, Qing-Song Jin, Yong-Jun Jin
Objective We aimed to evaluate the effect of 12-week aerobic exercise training on fetuin-A levels in type 2 diabetes mellitus and examine the relationships between fetuin-A and adipocytokine levels and cardiovascular risk factors. Methods The study included 32 patients with type 2 diabetes mellitus who were assigned to an exercise or a control group. The exercise group underwent 12 weeks of exercise (consisting of a 5-min warm-up, 60-min aerobic bicycle training performed at 70% of the maximal heart rate, a cool-down period, 5 times/week)...
July 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28750432/hyperthyroidism-in-patients-with-graves-ophthalmopathy-and-thyroidal-skeletal-and-eye-muscle-specific-type-2-deiodinase-enzyme-activities
#8
Ildikó Molnár, József A Szentmiklósi, Éva Somogyiné-Vári
Graves' ophthalmopathy is characterized by hyperthyroidism, which is associated with higher serum T3 levels than T4 due to deiodinase enzymes.The effect of Graves' patient's sera (n=52) with elevated thyroid hormone and TSH receptor or thyroid peroxidase antibody (anti-TPO) levels was investigated on thyroidal, skeletal and eye muscle type 2 deiodinase enzyme (DII) activities. DII activities were measured with (125)I-T4 substrate, while thyroid hormone and antibody levels with immunoassays.In Graves' ophthalmopathy, sera with elevated FT4 or FT3 levels reduced DII activites remarkably in all tissue fractions...
July 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28750431/nitric-oxide-plasma-level-as-a-barometer-of-endothelial-dysfunction-in-factory-workers
#9
Seiko Miyata, Akiko Noda, Yuki Hara, Jun Ueyama, Kiyoyuki Kitaichi, Takaaki Kondo, Yasuo Koike
Objective Nitric oxide (NO) plays a key role in the regulation of vascular tone and is known as one of the key markers of endothelial dysfunction. We investigated the relationship between NO and risk factors of lifestyle-related disease in factory workers. Methods Our study included 877 factory workers presenting hypertension, dyslipidemia and type 2 diabetes. oxidated forms of NO, NO2-/NO3- (NOx) plasma concentrations were measured using a colorimetric method. Results NOx plasma levels in patients with lifestyle-related disease were significantly lower than those in the controls...
July 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28750429/self-reported-hypoglycaemic-events-in-2%C3%A2-430-patients-with-insulin-treated-diabetes-in-the-german-sub-population-of-the-hat-study
#10
Werner Kern, Andreas Holstein, Christian Moenninghoff, Joachim Kienhöfer, Matthias Riedl, Bernhard Kulzer
Data concerning true hypoglycaemic incidence in insulin-treated patients with diabetes in real-world clinical practice are lacking in Germany. The aim of this analysis was to determine the incidence of hypoglycaemia experienced by the German cohort of patients enrolled in the global Hypoglycaemia Assessment Tool (HAT) study. This was a non-interventional, 6-month retrospective and 4-week prospective study using self-assessment questionnaires and patient diaries assessing patients aged ≥18 years in Germany, with type 1 diabetes (T1D) (n=811) or type 2 diabetes (T2D) (n=1 619) treated with insulin for >12 months...
July 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28750428/experiences-in-sensor-augmented-pump-therapy-in-families-with-two-children-with-type-1-diabetes-a-qualitative-study
#11
Franziska Bomba, Esther Müller-Godeffroy, Simone von Sengbusch
Background Caring for a child with type 1 diabetes is a tremendous challenge for a family. The aim of the study was to explore the experiences of transition to sensor-augmented pump therapy (SAP) in families with 2 affected children and the internal and external conditions which potentially impede or facilitate the adjustment process. Methods 5 families (9 parents, 8 children and adolescents) who used the SAP technology for 6 months were interviewed to describe their experiences. The interviews were analysed using thematic content analysis...
July 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28750427/environmental-risk-factors-for-type-1-diabetes-mellitus-development
#12
Boljat Antonela, Gunjača Ivana, Konstantinović Ivan, Vidan Nikolina, Boraska Perica Vesna, Pehlić Marina, Škrabić Veselin, Zemunik Tatijana
Background Although environmental factors induce development of type 1 diabetes mellitus (T1DM) in genetically susceptible individuals, many of those factors have been uncovered. Therefore, the aim of the present study was to analyze associations of T1DM with a wide range of environmental factors. Material and Methods A case-control study was conducted on 249 diabetic and 255 healthy individuals from the Dalmatian region of South Croatia. Data regarding risk factors during pregnancy and early life period of the child were evaluated...
July 27, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28750422/-atorvastatin-therapy-under-clinical-practice-conditions-which-ldl-c-levels-are-achieved-in-patients-at-very-high-cardiovascular-risk
#13
Ulrich Laufs, Christina Jannowitz, David Pittrow
Current information on the utilisation of atorvastatin under clinical practice conditions is limited. The cross sectional study DISCOVER documented in the period from June until December 2014 dose and effects on lipids in ambulatory patients at very high cardiovascular risk, who were treated with atorvastatin monotherapy (original drug or generics). Of 2625 patients (mean age 66.1 ± 10.8 years, 62.1 % males), 47.0 % had coronary heart disease (CHD), 25.1 % type 2 diabetes mellitus (DM), and 27.9 % CHD plus concomitant DM...
July 27, 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28750420/a-10-year-observational-study-of-streptococcus-dysgalactiae-bacteraemia-in-adults-frequent-occurrence-among-female-intravenous-drug-users
#14
Corinne Ruppen, Magnus Rasmussen, Carlo Casanova, Parham Sendi
Beta-haemolytic streptococci of groups C and G have become increasingly recognized as causes of invasive human infections. We reviewed clinical and molecular characteristics of Streptococcus dysgalactiae isolates that caused bacteraemia in adults from 2006 to 2015. Among 67 episodes, skin and soft-tissue infections (43%) and emm types stG62647.0 (26%) were the most frequent clinical manifestation and emm type, respectively. Nineteen (28%) episodes occurred in intravenous drug users (75% women). Our observational study shows similarities to but also differences from other reports...
July 27, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28750406/a-high-fat-diet-during-pregnancy-and-lactation-induces-cardiac-and-renal-abnormalities-in-glut4-male-mice
#15
Michael Kruse, Ariana Fiallo, Jianling Tao, Katalin Susztak, Kerstin Amann, Ellen B Katz, Maureen J Charron
BACKGROUND/AIMS: Altered nutrients during the in utero (IU) and/or lactation (L) period predispose offspring to cardio-renal diseases in adulthood. This study investigates the effect of a high fat diet (HFD) fed to female mice during IU/L on gene expression patterns associated with heart and kidney failure and hypertension in male offspring. METHODS: Female wild type (WT) mice were fed either a HFD or control chow (C) prior to mating with males with a genetic heterozygous deletion of GLUT4 (G4+/-, a model of peripheral insulin resistance and hypertension) and throughout IU/L...
July 27, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28750401/a-practical-approach-to-tumor-heterogeneity-in-clinical-research-and-diagnostics
#16
Giorgio Stanta, Serena Bonin
This Pathobiology issue tries to better define the complex phenomenon of intratumor heterogeneity (ITH), mostly from a practical point of view. This topic has been chosen because ITH is a central issue in tumor development and has to be investigated directly in patient tissue and immediately applied in the treatment of the presenting patient. Different types of ITH should be considered: clonal genetic and epigenetic evolution, morphological heterogeneity, and tumor sampling, heterogeneity resulting from microenvironmental autocrine and paracrine interaction, and stochastic plasticity related to different functional cell efficiencies...
July 28, 2017: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28750372/contemporary-antiplatelet-treatment-in-acute-coronary-syndrome-patients-with-impaired-renal-function-undergoing-percutaneous-coronary-intervention
#17
Periklis Davlouros, Ioanna Xanthopoulou, John Goudevenos, Michalis Hamilos, Emmanouil Vavuranakis, George Sitafidis, Ioannis Kanakakis, Spyridon Deftereos, Dimitrios Alexopoulos
OBJECTIVES: To assess the clinical impact of impaired renal function (IRF), in "real-world" acute coronary syndrome (ACS) patients, receiving clopidogrel, prasugrel, or ticagrelor. METHODS: This was a prospective, observational, multicenter, cohort study of ACS patients undergoing percutaneous coronary interventions (PCI) with IRF (creatinine clearance <60 mL/min by Cockroft-Gault equation), who were recruited into the Greek Antiplatelet Registry (GRAPE). Patients were followed-up until 1 year for major adverse cardiovascular events (MACE; a composite of death, nonfatal myocardial infarction, urgent revascularization, and stroke) and BARC (Bleeding Academic Research Consortium) bleeding...
July 28, 2017: Cardiology
https://www.readbyqxmd.com/read/28750358/antitumor-potential-of-1-thiocarbamoyl-3-5-diaryl-4-5-dihydro-1h-pyrazoles-in-human-bladder-cancer-cells
#18
Josiane Weber Tessmann, Julieti Buss, Karine Rech Begnini, Lucas Moraes Berneira, Favero Reisdorfer Paula, Claudio Martin Pereira de Pereira, Tiago Collares, Fabiana Kömmling Seixas
Bladder cancer is a genitourinary malignant disease common worldwide. Current chemotherapy is often limited mainly due to toxicity and drug resistance. Thus, there is a continued need to discover new therapies. Recently evidences shows that pyrazoline derivatives are promising antitumor agents in many types of cancers, but there are no studies with bladder cancer. In order to find potent and novel chemotherapy drugs for bladder cancer, a series of pyrazoline derivatives 2a-2d were tested for their antitumor activity in two human bladder cancer cell lines 5647 and T24...
July 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28750357/protective-effects-of-wedelolactone-on-dextran-sodium-sulfate-induced-murine-colitis-partly-through-inhibiting-the-nlrp3-inflammasome-activation-via-ampk-signaling
#19
Wencheng Wei, Meiling Ding, Kai Zhou, Haifeng Xie, Mian Zhang, Chaofeng Zhang
It has been reported that the ethanol extract of Wedelia chinensis attenuates murine colitis. Wedelolactone (WEL), a coumestane-type compound with many pharmacological activities, was isolated from W. chinensis. The present study aims to investigate the beneficial effects and underlying mechanisms of WEL on ulcerative colitis. In a dextran sodium sulfate (DSS)-induced mouse model, oral administration of WEL (50mg/kg) significantly attenuated pathological colonic damage and inhibited inflammatory infiltration, myeloperoxidase and alkaline phosphatase activities through MAPKs and NF-κB signaling pathways, while activating AMPK in colons treated with DSS...
July 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28750355/doxazosin-nanoencapsulation-improves-its-in-vitro-antiproliferative-and-anticlonogenic-effects-on-breast-cancer-cells
#20
J Krai, A Beckenkamp, M M Gaelzer, A R Pohlmann, S S Guterres, E C Filippi-Chiela, C Salbego, A Buffon, R C R Beck
Doxazosin has been evaluated for the treatment of several types of cancer. Here, the antitumor effect of the nanoencapsulated form of doxazosin was evaluated in an in vitro model of breast cancer (MCF7 cell line). Doxazosin-loaded polymeric nanocapsules (DXZ-NC) were produced by interfacial deposition of preformed polymer with homogeneous aspect, spherical shape, mean diameter of about 130nm, positive zeta potential (+5mV), and encapsulation efficiency close to 35%. The Alamar Blue(®) assay and cell counting were carried out to assess cell viability and cell number, respectively...
July 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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