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https://www.readbyqxmd.com/read/29028402/effect-of-ion-clouds-micromotion-on-measured-signal-in-fourier-transform-ion-cyclotron-resonance-computer-simulation
#1
Gleb Vladimirov, Yury Kostyukevich, Oleg Kharybin, Eugene Nikolaev
Particle-in-cell-based realistic simulation of Fourier transform ion cyclotron resonance experiments could be used to generate ion trajectories and a signal induced on the detection electrodes. It has been shown recently that there is a modulation of "reduced" cyclotron frequencies in ion cyclotron resonance signal caused by Coulomb interaction of ion clouds. In this work it was proposed to use this modulation in order to determine frequency difference between an ion of known m/z and all other ions generating signal in ion cyclotron resonance cell...
August 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29028302/high-ion-exchange-capacity-semi-homogeneous-cation-exchange-membranes-prepared-via-a-novel-polymerization-and-sulfonation-approach-in-porous-polypropylene
#2
Shanxue Jiang, Bradley P Ladewig
Semi-homogeneous cation exchange membranes with superior ion exchange capacity (IEC) were synthesized via a novel polymerization and sulfonation approach in porous polypropylene support. The IEC of membranes could reach up to 3 mmol/g, due to high mass ratio of functional polymer to membrane support. Especially, theoretical IEC threshold value agreed well with experimental threshold value, indicating that IEC could be specifically designed without carrying out extensive experiments. Also, sulfonate groups were distributed both on membrane surface and across the membranes, which corresponded well with high IEC of the synthesized membranes...
October 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29027711/expansion-of-mesenchymal-stem-cells-on-electrospun-scaffolds-maintains-stemness-mechano-responsivity-and-differentiation-potential
#3
Su-Jin Heo, Spencer E Szczesny, Dong Hwa Kim, Kamiel S Saleh, Robert L Mauck
Mesenchymal stem cells (MSCs) hold great promise for regenerative therapies and tissue engineering applications given their multipotential differentiation capacity. However, MSC isolation and expansion are typically performed on super-physiologically stiff tissue culture plastic (TCP), which may alter their behavior and lead to unintended consequences upon implantation. In contrast, electrospun nanofibrous scaffolds possess physical and mechanical properties that are similar to that of native tissue. In this study, we investigated whether isolation and expansion of juvenile bovine MSCs directly onto electrospun nanofibrous scaffolds better preserves MSC phenotype and stemness compared to TCP...
October 13, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29026905/imaging-a%C3%AE-1-42-fibril-elongation-reveals-strongly-polarised-growth-and-growth-incompetent-states
#4
Laurence J Young, Gabriele S Kaminski Schierle, Clemens F Kaminski
The major hallmark of Alzheimer's disease is the deposition of plaques of amyloid fibrils formed from amyloid-β (Aβ) peptides. Kinetic studies have contributed significantly towards a mechanistic understanding of amyloid fibril self-assembly, however dynamic features of the aggregation process cannot be captured using ensemble methods. Here we present an assay for imaging Aβ42 aggregation dynamics at the single fibril level, allowing for the quantitative extraction of concentration and temperature dependent kinetic parameters...
October 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29026530/recent-advances-in-pericentriolar-material-organization-ordered-layers-and-scaffolding-gels
#5
REVIEW
Andrew M Fry, Josephina Sampson, Caroline Shak, Sue Shackleton
The centrosome is an unusual organelle that lacks a surrounding membrane, raising the question of what limits its size and shape. Moreover, while electron microscopy (EM) has provided a detailed view of centriole architecture, there has been limited understanding of how the second major component of centrosomes, the pericentriolar material (PCM), is organized. Here, we summarize exciting recent findings from super-resolution fluorescence imaging, structural biology, and biochemical reconstitution that together reveal the presence of ordered layers and complex gel-like scaffolds in the PCM...
2017: F1000Research
https://www.readbyqxmd.com/read/29026218/igd-class-switch-recombination-is-not-controlled-through-the-immunoglobulin-heavy-chain-3-regulatory-region-super-enhancer
#6
Hussein Issaoui, Nour Ghazzaui, Alexis Saintamand, Yves Denizot, François Boyer
No abstract text is available yet for this article.
October 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29026093/crystal-structure-of-the-flexible-tandem-repeat-domain-of-bacterial-cellulose-synthesis-subunit-c
#7
Shingo Nojima, Ayumi Fujishima, Koji Kato, Kayoko Ohuchi, Nobutaka Shimizu, Kento Yonezawa, Kenji Tajima, Min Yao
Bacterial cellulose (BC) is synthesized and exported through the cell membrane via a large protein complex (terminal complex) that consists of three or four subunits. BcsC is a little-studied subunit considered to export BC to the extracellular matrix. It is predicted to have two domains: a tetratrico peptide repeat (TPR) domain and a β-barrelled outer membrane domain. Here we report the crystal structure of the N-terminal part of BcsC-TPR domain (Asp24-Arg272) derived from Enterobacter CJF-002. Unlike most TPR-containing proteins which have continuous TPR motifs, this structure has an extra α-helix between two clusters of TPR motifs...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025936/complete-genome-sequence-of-super-biofilm-elaborating-staphylococcus-aureus-isolated-in-japan
#8
Liansheng Yu, Junzo Hisatsune, Hideki Hirakawa, Emiri Mizumachi, Atsushi Toyoda, Koji Yahara, Motoyuki Sugai
Staphylococcus aureus JP080, previously named TF2758, is a clinical isolate from an atheroma and a super biofilm-elaborating strain whose biofilm elaboration is dependent solely on polysaccharide poly-N-acetylglucosamine/polysaccharide intercellular adhesin (PNAG/PIA). Here, we report the complete genome sequence of strain JP080, which consists of one chromosome and one circular plasmid.
October 12, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29025827/influence-of-social-deprivation-on-provision-of-bariatric-surgery-10-year-comparative-ecological-study-between-two-uk-specialist-centres
#9
Shivam Bhanderi, Mushfique Alam, Jacob Henry Matthews, Gavin Rudge, Hamish Noble, David Mahon, Martin Richardson, Richard Welbourn, Paul Super, Rishi Singhal
OBJECTIVE: To investigate the effect of residential location and socioeconomic deprivation on the provision of bariatric surgery. DESIGN: Retrospective cross-sectional ecological study. SETTING: Patients resident local to one of two specialist bariatric units, in different regions of the UK, who received obesity surgery between 2003 and 2013. METHODS: Demographic data were collected from prospectively collected databases...
October 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29024646/the-epstein-barr-virus-regulome-in-lymphoblastoid-cells
#10
Sizun Jiang, Hufeng Zhou, Jun Liang, Catherine Gerdt, Chong Wang, Liangru Ke, Stefanie C S Schmidt, Yohei Narita, Yijie Ma, Shuangqi Wang, Tyler Colson, Benjamin Gewurz, Guoliang Li, Elliott Kieff, Bo Zhao
Epstein-Barr virus (EBV) transforms B cells to continuously proliferating lymphoblastoid cell lines (LCLs), which represent an experimental model for EBV-associated cancers. EBV nuclear antigens (EBNAs) and LMP1 are EBV transcriptional regulators that are essential for LCL establishment, proliferation, and survival. Starting with the 3D genome organization map of LCL, we constructed a comprehensive EBV regulome encompassing 1,992 viral/cellular genes and enhancers. Approximately 30% of genes essential for LCL growth were linked to EBV enhancers...
October 11, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/29023235/a-generally-efficient-targeted-minimum-loss-based-estimator-based-on-the-highly-adaptive-lasso
#11
Mark van der Laan
Suppose we observe n $n$ independent and identically distributed observations of a finite dimensional bounded random variable. This article is concerned with the construction of an efficient targeted minimum loss-based estimator (TMLE) of a pathwise differentiable target parameter of the data distribution based on a realistic statistical model. The only smoothness condition we will enforce on the statistical model is that the nuisance parameters of the data distribution that are needed to evaluate the canonical gradient of the pathwise derivative of the target parameter are multivariate real valued cadlag functions (right-continuous and left-hand limits, (G...
October 12, 2017: International Journal of Biostatistics
https://www.readbyqxmd.com/read/29023118/mixed-penetrant-sorption-in-ultra-thin-films-of-polymer-of-intrinsic-microporosity-pim-1
#12
Wojciech Ogieglo, Andreas Furchner, Bader S Ghanem, Xiao-Hua Ma, Ingo Pinnau, Matthias Wessling
Mixed penetrant sorption into ultra-thin films of a super-glassy polymer of intrinsic microporosity (PIM-1) was studied for the first time by using interference-enhanced in-situ spectroscopic ellipsometry. PIM-1 swelling and the concurrent changes in its refractive index were determined in ultra-thin (12 - 14 nm) films exposed to pure and mixed penetrants. The penetrants included water, n-hexane and ethanol and were chosen based on their significantly different penetrant-penetrant and penetrant-polymer affinities...
October 12, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29022756/soluble-guanylyl-cyclase-is-a-critical-regulator-of-migraine-associated-pain
#13
Manel Ben Aissa, Alycia F Tipton, Zachariah Bertels, Ronak Gandhi, Laura S Moye, Madeline Novack, Brian M Bennett, Yueting Wang, Vladislav Litosh, Sue H Lee, Irina N Gaisina, Gregory Rj Thatcher, Amynah A Pradhan
Background Nitric oxide (NO) has been heavily implicated in migraine. Nitroglycerin is a prototypic NO-donor, and triggers migraine in humans. However, nitroglycerin also induces oxidative/nitrosative stress and is a source of peroxynitrite - factors previously linked with migraine etiology. Soluble guanylyl cyclase (sGC) is the high affinity NO receptor in the body, and the aim of this study was to identify the precise role of sGC in acute and chronic migraine. Methods We developed a novel brain-bioavailable sGC stimulator (VL-102), and tested its hyperalgesic properties in mice...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29022562/ketogenic-diet-in-endocrine-disorders-current-perspectives
#14
REVIEW
L Gupta, D Khandelwal, S Kalra, P Gupta, D Dutta, S Aggarwal
Ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to nutritional ketosis, long known for antiepileptic effects and has been used therapeutically to treat refractory epilepsy. This review attempts to summarize the evidence and clinical application of KD in diabetes, obesity, and other endocrine disorders. KD is usually animal protein based. An empiric vegetarian Indian variant of KD has been provided keeping in mind the Indian food habits. KD has beneficial effects on cardiac ischemic preconditioning, improves oxygenation in patients with respiratory failure, improves glycemic control in diabetics, is associated with significant weight loss, and has a beneficial impact on polycystic ovarian syndrome...
October 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/29019654/transition-metal-free-radical-c-sp3-c-sp2-and-c-sp3-c-sp3-coupling-enabled-by-2-azaallyls-as-super-electron-donors-and-coupling-partners
#15
Minyan Li, Simon Berritt, Lucas Matuszewski, Guogang Deng, Ana Pascual-Escudero, Grace B Panetti, Michal Poznik, Xiaodong Yang, Jason J Chruma, Patrick J Walsh
The past decade has witnessed the rapid development of radical generation strategies and their applications in C-C bond-forming reactions. Most of these processes require initiators, transition metal catalysts or organometallic reagents. Herein, we report the discovery of a simple organic system (2-azaallyl anions) that enables radical coupling reactions under transition-metal-free conditions. Deprotonation of N-benzyl ketimines generates semi-stabilized 2-azaallyl anions that behave as "super-electron-donors" (SEDs) and reduce aryl iodides and alkyl halides to aryl and alkyl radicals...
October 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29019494/relativistic-dft-investigation-of-electronic-structure-effects-arising-from-doping-the-au25-nanocluster-with-transition-metals
#16
Fahri Alkan, Alvaro Muñoz-Castro, Christine M Aikens
We perform a theoretical investigation using density functional theory (DFT) and time-dependent DFT (TDDFT) on the doping of the Au25(SR)18(-1) nanocluster with group IX transition metals (M = cobalt, rhodium and iridium). Different doping motifs, charge states and spin multiplicities were considered for the single-atom doped nanoclusters. Our results show that the interaction (or the lack of interaction) between the d-type energy levels that mainly originate from the dopant atom and the super-atomic levels plays an important role in the energetics, the electronic structure and the optical properties of the doped systems...
October 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/29018437/biocontrol-of-bacterial-leaf-blight-of-rice-and-profiling-of-secondary-metabolites-produced-by-rhizospheric-pseudomonas-aeruginosa-brp3
#17
Sumera Yasmin, Fauzia Y Hafeez, Muhammad S Mirza, Maria Rasul, Hafiz M I Arshad, Muhammad Zubair, Mazhar Iqbal
Xanthomonas oryzae pv. oryzae (Xoo) is widely prevalent and causes Bacterial Leaf Blight (BLB) in Basmati rice grown in different areas of Pakistan. There is a need to use environmentally safe approaches to overcome the loss of grain yield in rice due to this disease. The present study aimed to develop inocula, based on native antagonistic bacteria for biocontrol of BLB and to increase the yield of Super Basmati rice variety. Out of 512 bacteria isolated from the rice rhizosphere and screened for plant growth promoting determinants, the isolate BRp3 was found to be the best as it solubilized 97 μg/ mL phosphorus, produced 30 μg/mL phytohormone indole acetic acid and 15 mg/ L siderophores in vitro...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29018363/moderate-load-muscular-endurance-strength-training-did-not-improve-peak-power-or-functional-capacity-in-older-men-and-women
#18
Simon Walker, Guy G Haff, Keijo Häkkinen, Robert U Newton
The present study determined the effects of muscular endurance strength training on maximum strength and power, functional capacity, muscle activation and hypertrophy in older men and women. Eighty-one men and women acted as an intervention group while 22 acted as non-training controls (age range 64-75 y). Intervention training included super-sets (i.e., paired exercises, immediately performing the second exercises following completion of the first) with short rest intervals (30-60 s between sets) at an intensity of 50-60% one-repetition maximum (1-RM) for 15-20 repetitions...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29017057/a-p53-super-tumor-suppressor-reveals-a-tumor-suppressive-p53-ptpn14-yap-axis-in-pancreatic-cancer
#19
Stephano S Mello, Liz J Valente, Nitin Raj, Jose A Seoane, Brittany M Flowers, Jacob McClendon, Kathryn T Bieging-Rolett, Jonghyeob Lee, Danton Ivanochko, Margaret M Kozak, Daniel T Chang, Teri A Longacre, Albert C Koong, Cheryl H Arrowsmith, Seung K Kim, Hannes Vogel, Laura D Wood, Ralph H Hruban, Christina Curtis, Laura D Attardi
The p53 transcription factor is a critical barrier to pancreatic cancer progression. To unravel mechanisms of p53-mediated tumor suppression, which have remained elusive, we analyzed pancreatic cancer development in mice expressing p53 transcriptional activation domain (TAD) mutants. Surprisingly, the p53(53,54) TAD2 mutant behaves as a "super-tumor suppressor," with an enhanced capacity to both suppress pancreatic cancer and transactivate select p53 target genes, including Ptpn14. Ptpn14 encodes a negative regulator of the Yap oncoprotein and is necessary and sufficient for pancreatic cancer suppression, like p53...
October 9, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29016821/super-response-to-cardiac-resynchronization-therapy-reduces-appropriate-implantable-cardioverter-defibrillator-therapy
#20
Ammar M Killu, Anna Mazo, Avishay Grupper, Malini Madhavan, Tracy Webster, Kelly L Brooke, David O Hodge, Samuel J Asirvatham, Paul A Friedman, Michael Glikson, Yong-Mei Cha
Aims: To determine the frequency of implantable cardioverter defibrillator (ICD) therapy following cardiac resynchronization therapy (CRT-D) implantation in super and non-super responders and whether greater improvement in left ventricular (LV) function after CRT is associated with a reduced burden in ICD therapy. Methods and results: This is a two-centre, retrospective study between January 2002 and September 2011. Patients were classified as non-super responders and super-responders based on the post-CRT ejection fraction (EF) of < 50% and ≥50%, respectively...
August 4, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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