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https://www.readbyqxmd.com/read/29236082/low-cost-plastic-optical-fiber-pressure-sensor-embedded-in-mattress-for-vital-signal-monitoring
#1
Demetrio Sartiano, Salvador Sales
The aim of this paper is to report the design of a low-cost plastic optical fiber (POF) pressure sensor, embedded in a mattress. We report the design of a multipoint sensor, a cheap alternative to the most common fiber sensors. The sensor is implemented using Arduino board, standard LEDs for optical communication in POF (λ = 645 nm) and a silicon light sensor. The Super ESKA® plastic fibers were used to implement the fiber intensity sensor, arranged in a 4 × 4 matrix. During the breathing cycles, the force transmitted from the lungs to the thorax is in the order of tens of Newtons, and the respiration rate is of one breath every 2-5 s (0...
December 13, 2017: Sensors
https://www.readbyqxmd.com/read/29235727/mnco2o4-moo2-nanosheets-grown-on-ni-foam-as-carbon-and-binder-free-cathode-for-lithium-oxygen-batteries-with-long-life-and-high-efficiency
#2
Xuecheng Cao, Zhihui Sun, Xiangjun Zheng, Chao Jin, Jinghua Tian, Xiaowei Li, Ruizhi Yang
Carbon is usually used as cathode material for Li-O2 batteries. However, the discharge product, such as Li2O2 and LiO2, could react with carbon to form insulating lithium carbonate layer, resulting in cathode passivation and capacity fading. To solve this problem, the development of non-carbon cathode is highly demanded. Herein, we have successfully synthesized MnCo2O4 (MCO) nanoparticles anchored on porous MoO2 nanosheets that are grown on Ni foam (current collector) (MCO/MoO2@Ni), acting as a carbon- and binder-free cathode for Li-O2 batteries, in an attempt to improve the electrical conductivity, electrocatalytic activity and durability...
December 13, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29235599/modelling-oral-up-take-of-hydrophobic-and-super-hydrophobic-chemicals-in-fish
#3
Wolfgang Larisch, Kai-Uwe Goss
We have extended a recently published toxicokinetic model for fish (TK-fish) towards the oral up-take of contaminants. Validation with hydrophobic chemicals revealed that diffusive transport through aqueous boundary layers in the gastro-intestinal tract and in the blood is the limiting process. This process can only be modelled correctly if facilitated transport by albumin or bile micelles through these boundary layers is accounted for. In a case study we have investigated the up-take of a super hydrophobic chemical, Dechlorane Plus...
December 13, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29235440/leveraging-multi-layer-imager-detector-design-to-improve-low-dose-performance-for-megavoltage-cone-beam-computed-tomography
#4
Yue-Houng Hu, Joerg Rottmann, Rony Fueglistaller, Marios E Myronakis, Adam Wang, Pascal Huber, Daniel Shedlock, Daniel Morf, Paul Baturin, Josh M Star-Lack, Ross I Berbeco
While megavoltage (MV) cone-beam computed tomography (CBCT) using an electronic portal imaging device (EPID) provides many advantages over kilovoltage (kV) CBCT, clinical adoption is limited by its high doses. Multi-layer imager (MLI) EPIDs increase DQE(0) while maintaining high resolution. However, even well-designed, high-performance MLIs suffer from increased electronic noise from each readout, degrading low-dose image quality. To improve low-dose performance, shift-and-bin addition (ShiBA) imaging is proposed, leveraging the unique architecture of the MLI...
December 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29235011/comparative-effectiveness-of-laparoscopic-sleeve-gastrectomy-on-morbidly-obese-super-obese-and-super-super-obese-patients-for-the-treatment-of-morbid-obesity
#5
Ilhan Ece, Huseyin Yilmaz, Husnu Alptekin, Serdar Yormaz, Bayram Colak, Farise Yilmaz, Mustafa Sahin
BACKGROUNDS: The management of super-super obese patients is challenging for bariatric surgeons. Laparoscopic sleeve gastrectomy (LSG) is feasible as two-stage treatment for high-risk patients. However, its efficacy as a stand-alone procedure in super-super obese (SSO) patients is controversial. The study objective was to demonstrate the safety and efficacy of LSG in super-obese (SO) and SSO patients. METHODS: A retrospective analysis was performed of consecutive patients undergoing LSG...
December 12, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29234303/a-study-of-super-refractory-status-epilepticus-from-india
#6
Usha K Misra, Jayantee Kalita, Deepanshu Dubey
Background: Super refractory status epilepticus (SRSE) is an important and recently recognized neurological emergency. Purpose: In view of paucity of studies on SRSE, we report the frequency, etiology and outcome of SRSE. Methods: In a hospital-based observational study during 2013 to 2016, consecutive patients with SRSE [persistence of status epilepticus (SE) for 24 h or more, or recurrence of SE on weaning of intravenous anesthetic] were included...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29234096/transit-and-integration-of-extracellular-mitochondria-in-human-heart-cells
#7
Douglas B Cowan, Rouan Yao, Jerusha K Thedsanamoorthy, David Zurakowski, Pedro J Del Nido, James D McCully
Tissue ischemia adversely affects the function of mitochondria, which results in impairment of oxidative phosphorylation and compromised recovery of the affected organ. The impact of ischemia on mitochondrial function has been extensively studied in the heart because of the morbidity and mortality associated with injury to this organ. As conventional methods to preserve cardiac cell viability and contractile function following ischemia are limited in their efficacy, we developed a unique approach to protect the heart by transplanting respiration-competent mitochondria to the injured region...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233999/multiplexed-3d-super-resolution-imaging-of-whole-cells-using-spinning-disk-confocal-microscopy-and-dna-paint
#8
Florian Schueder, Juanita Lara-Gutiérrez, Brian J Beliveau, Sinem K Saka, Hiroshi M Sasaki, Johannes B Woehrstein, Maximilian T Strauss, Heinrich Grabmayr, Peng Yin, Ralf Jungmann
Single-molecule localization microscopy (SMLM) can visualize biological targets on the nanoscale, but complex hardware is required to perform SMLM in thick samples. Here, we combine 3D DNA points accumulation for imaging in nanoscale topography (DNA-PAINT) with spinning disk confocal (SDC) hardware to overcome this limitation. We assay our achievable resolution with two- and three-dimensional DNA origami structures and demonstrate the general applicability by imaging a large variety of cellular targets including proteins, DNA and RNA deep in cells...
December 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29233914/had1-is-required-for-cell-wall-integrity-and-fungal-virulence-in-cryptococcus-neoformans
#9
Won-Hee Jung, Ye-Eun Son, Sang-Hun Oh, Ci Fu, Hye Shin Kim, Jin-Hwan Kwak, Maria E Cardenas, Joseph Heitman, Hee-Soo Park
Calcineurin modulates environmental stress survival and virulence of the human fungal pathogen Cryptococcus neoformans Previously, we identified 44 putative calcineurin substrates and proposed that the calcineurin pathway is branched to regulate targets including Crz1, Pbp1, and Puf4 in C. neoformans In this study we characterized Had1, which is one of the putative calcineurin substrates and belongs to a ubiquitously conserved haloacid dehalogenase β-phosphoglucomutase protein super-family. Growth of the had1∆ mutant was found to be compromised at 38°C or higher...
December 12, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29233218/secondary-nucleation-of-monomers-on-fibril-surface-dominates-%C3%AE-synuclein-aggregation-and-provides-autocatalytic-amyloid-amplification
#10
Ricardo Gaspar, Georg Meisl, Alexander K Buell, Laurence Young, Clemens F Kaminski, Tuomas P J Knowles, Emma Sparr, Sara Linse
Parkinson's disease (PD) is characterized by proteinaceous aggregates named Lewy Bodies and Lewy Neurites containing α-synuclein fibrils. The underlying aggregation mechanism of this protein is dominated by a secondary process at mildly acidic pH, as in endosomes and other organelles. This effect manifests as a strong acceleration of the aggregation in the presence of seeds and a weak dependence of the aggregation rate on monomer concentration. The molecular mechanism underlying this process could be nucleation of monomers on fibril surfaces or fibril fragmentation...
January 2017: Quarterly Reviews of Biophysics
https://www.readbyqxmd.com/read/29233123/impact-of-place-of-residence-on-place-of-death-in-wales-an-observational-study
#11
S R Ziwary, D Samad, C D Johnson, R T Edwards
BACKGROUND: Previous research in England showed that deprivation level of a person's place of residence affects the place of death and quality of care received at the end of life. People dying in their preferred place of death has also been shown to act as an indication for high quality of end of life care services and social equality. This study expands on current research to explore the effects of deprivation and place of residence on health related choices and place of death in Wales...
December 12, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/29232909/synergistic-effects-of-bacillus-amyloliquefaciens-gb03-and-water-retaining-agent-on-drought-tolerance-of-perennial-ryegrass
#12
An-Yu Su, Shu-Qi Niu, Yuan-Zheng Liu, Ao-Lei He, Qi Zhao, Paul W Paré, Meng-Fei Li, Qing-Qing Han, Sardar Ali Khan, Jin-Lin Zhang
Water retaining agent (WRA) is widely used for soil erosion control and agricultural water saving. Here, we evaluated the effects of the combination of beneficial soil bacterium Bacillus amyloliquefaciens strain GB03 and WRA (the compound is super absorbent hydrogels) on drought tolerance of perennial ryegrass (Lolium perenne L.). Seedlings were subjected to natural drought for maximum 20 days by stopping watering and then rewatered for seven days. Plant survival rate, biomass, photosynthesis, water status and leaf cell membrane integrity were measured...
December 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29232142/janus-iron-oxides-semiconducting-polymer-nanoparticle-tracer-for-cell-tracking-by-magnetic-particle-imaging
#13
Guosheng Song, Min Chen, Yanrong Zhang, Liyang Cui, Haibo Qu, Xianchuang Zheng, Max Wintermark, Zhuang Liu, Jianghong Rao
Iron oxides nanoparticles tailored for magnetic particle imaging (MPI) have been synthesized, and their MPI signal intensity is 3 times of commercial MPI contrast (Ferucarbotran, also called Vivotrax) and 7 times of MRI contrast (Feraheme) at the same Fe concentration. MPI tailored iron oxide nanoparticles were encapsulated with semiconducting polymers to produce Janus nanoparticles that possessed optical and magnetic properties for MPI and fluorescence imaging. Janus particles were applied to cancer cell labeling and in vivo tracking, and as few as 250 cells were imaged by MPI after implantation, corresponding to an amount of 7...
December 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/29230050/synaptic-weight-set-by-munc13-1-supramolecular-assemblies
#14
Hirokazu Sakamoto, Tetsuroh Ariyoshi, Naoya Kimpara, Kohtaroh Sugao, Isamu Taiko, Kenji Takikawa, Daisuke Asanuma, Shigeyuki Namiki, Kenzo Hirose
The weight of synaptic connections, which is controlled not only postsynaptically but also presynaptically, is a key determinant in neuronal network dynamics. The mechanisms controlling synaptic weight, especially on the presynaptic side, remain elusive. Using single-synapse imaging of the neurotransmitter glutamate combined with super-resolution imaging of presynaptic proteins, we identify a presynaptic mechanism for setting weight in central glutamatergic synapses. In the presynaptic terminal, Munc13-1 molecules form multiple and discrete supramolecular self-assemblies that serve as independent vesicular release sites by recruiting syntaxin-1, a soluble N-ethylmaleimide-sensitive-factor attachment receptor (SNARE) protein essential for synaptic vesicle exocytosis...
December 11, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/29229003/comparative-binding-properties-of-the-tau-pet-tracers-thk5117-thk5351-pbb3-and-t807-in-postmortem-alzheimer-brains
#15
Laetitia Lemoine, Per-Göran Gillberg, Marie Svedberg, Vladimir Stepanov, Zhisheng Jia, Jinghai Huang, Sangram Nag, He Tian, Bernardino Ghetti, Nobuyuki Okamura, Makoto Higuchi, Christer Halldin, Agneta Nordberg
BACKGROUND: The aim of this study was to compare the binding properties of several tau positron emission tomography tracers-THK5117, THK5351, T807 (also known as AV1451; flortaucipir), and PBB3-head to head in the same human brain tissue. METHODS: Binding assays were performed to compare the regional distribution of 3H-THK5117 and 3H-THK5351 in postmortem tissue from three Alzheimer's disease (AD) cases and three control subjects in frontal and temporal cortices as well as in the hippocampus...
December 11, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29228723/an-ngs-based-approach-for-the-identification-of-sex-specific-markers-in-snakehead-channa-argus
#16
Mi Ou, Cheng Yang, Qing Luo, Rong Huang, Ai-Di Zhang, Lan-Jie Liao, Yong-Ming Li, Li-Bo He, Zuo-Yan Zhu, Kun-Ci Chen, Ya-Ping Wang
We described a next generation sequencing (NGS)-based approach to identify sex-specific markers and subsequently determine whether a species has male or female heterogamety. To test the accuracy of this technique, we examined the snakehead (Channa argus), which is economically important freshwater fish in China. Males grow faster than females, and there is significant interest in developing methods to skew breeding towards all-males to increase biomass yields. NGS was conducted on DNAs of individual female and male, the male reads were spitted into 60 bp K-mers and aligned to the female reference genome assembled by female reads, unaligned male K-mers-60 were kept in next filter process...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228321/a-conceptual-framework-for-understanding-the-mechanism-of-action-of-community-health-workers-services-the-centrality-of-social-support
#17
Beck Taylor, Jonathan Mathers, Jayne Parry
Objective: To propose an empirically derived and theoretically-informed mechanism to explain how Community Health Workers (CHWs) bring about health gain in clients in England. Methods: We undertook in-depth interviews (n = 43) with CHWs and service staff working in four case studies selected using maximum variation sampling. Interviewees were encouraged to talk about the service, how they had become involved with the service, the CHW role and relationship with clients...
December 8, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/29227820/the-ultimate-picture-the-combination-of-live-cell-superresolution-microscopy-and-single-molecule-tracking-yields-highest-spatio-temporal-resolution
#18
REVIEW
Simon Dersch, Peter L Graumann
We are witnessing a breathtaking development in light (fluorescence) microscopy, where structures can be resolved down to the size of a ribosome within cells. This has already yielded surprising insight into the subcellular structure of cells, including the smallest cells, bacteria. Moreover, it has become possible to visualize and track single fluorescent protein fusions in real time, and quantify molecule numbers within individual cells. Combined, super resolution and single molecule tracking are pushing the limits of our understanding of the spatio-temporal organization even of the smallest cells to an unprecedented depth...
December 8, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29227618/tackling-the-challenges-of-dynamic-experiments-using-liquid-cell-transmission-electron-microscopy
#19
Lucas R Parent, Evangelos Bakalis, Maria Proetto, Yiwen Li, Chiwoo Park, Francesco Zerbetto, Nathan C Gianneschi
Revolutions in science and engineering frequently result from the development, and wide adoption, of a new, powerful characterization or imaging technique. Beginning with the first glass lenses and telescopes in astronomy, to the development of visual-light microscopy, staining techniques, confocal microscopy, and fluorescence super-resolution microscopy in biology, and most recently aberration-corrected, cryogenic, and ultrafast (4D) electron microscopy, X-ray microscopy, and scanning probe microscopy in nanoscience...
December 11, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29227461/population-pharmacokinetics-of-lopinavir-in-severely-malnourished-hiv-infected-children-and-the-effect-on-treatment-outcomes
#20
Moherndran Archary, Helen Mcllleron, Raziya Bobat, Phillip La Russa, Thobekile Sibaya, Lubbe Wiesner, Stefanie Hennig
BACKGROUND: In developing countries, malnutrition remains a common clinical syndrome at antiretroviral treatment (ART) initiation. Physiological changes due to malnutrition and during nutritional recovery could affect the pharmacokinetics of antiretroviral drugs. METHODS: HIV-infected children admitted with severe acute malnutrition were randomised to early or delayed initiation of lopinavir/ritonavir, abacavir and lamivudine using WHO weight-band dosage charts...
December 8, 2017: Pediatric Infectious Disease Journal
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