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https://www.readbyqxmd.com/read/29452225/seminars-in-cell-and-developmental-biology-human-dendritic-cell-immunodeficiencies
#1
REVIEW
Venetia Bigley, Urszula Cytlak, Matthew Collin
The critical functions of dendritic cells (DCs) in immunity and tolerance have been demonstrated in many animal models but their non-redundant roles in humans are more difficult to probe. Human primary immunodeficiency (PID), resulting from single gene mutations, may result in DC deficiency or dysfunction. This relatively recent recognition illuminates the in vivo role of human DCs and the pathophysiology of the associated clinical syndromes. In this review, the development and function of DCs as established in murine models and human in vitro systems, is discussed...
February 13, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29451772/ultra-flexible-and-high-performance-multilayer-transparent-electrode-based-on-zno-ag-cuscn
#2
Yixiong Ji, Jun Yang, Wei Luo, Linlong Tang, Xiangxing Bai, Chongqian Leng, Chaoyan Ma, Xingzhan Wei, Jing Wang, Jun Shen, Shirong Lu, Kuan Sun, Haofei Shi
Driven by huge demand for flexible opto-electronic devices, high-performance flexible transparent electrodes are continuously sought. In this work, a flexible multilayer transparent electrode with structure of ZnO/Ag/CuSCN (ZAC) is engineered, featuring inorganic solution-processed cuprous thiocyanate (CuSCN) as a hole-transport antireflection coating. The ZAC electrode exhibits an average transmittance of 94% (discounting the substrate) in the visible range, a sheet resistance (Rsh) of 9.7 Ω/sq, a high mechanical flexibility without Rsh variation after bending 10,000 times, a long-term stability of 400 days in ambient environment and scalable fabrication process...
February 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29451353/in-vitro-cytotoxicity-assessment-of-nanodiamond-particles-and-their-osteogenic-potential
#3
Mohamed Ibrahim, Ying Xue, Melanie Ostermann, Alexander Sauter, Doris Steinmueller-Nethl, Sarah Schweeberg, Anke Krueger, Mihaela R Cimpan, Kamal Mustafa
Scaffolds functionalized with nanodiamond particles (nDP) hold great promise with regard to bone tissue formation in animal models. Degradation of the scaffolds over time may leave nDP within the tissues, raising concerns about possible long-term unwanted effects. Human SaOS-2 osteoblast-like cells and U937 monoblastoid cells were exposed to 5 different concentrations (0.002-2 mg/L) of nDP (size range: 2.36 - 4.42 nm) for 24 h. Cell viability was assessed by impedance-based methods. The differential expression of stress and toxicity-related genes was evaluated by PCR super-array, while the expression of selected inflammatory and cell death markers was determined by qPCR...
February 16, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29450865/erratum-to-super-resolution-single-molecule-fish-at-the-drosophila-neuromuscular-junction
#4
Joshua S Titlow, Lu Yang, Richard M Parton, Ana Palanca, Ilan Davis
No abstract text is available yet for this article.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29450850/recurrent-fever-and-arthralgia-as-the-presentation-of-tumor-necrosis-factor-receptor-associated-periodic-syndrome-traps-in-a-chinese-girl-a-case-report-and-review-of-the-literature
#5
REVIEW
Yanxia Chen, Xingqi Huang, Sujie Zheng, Zhongliang Zhu, Wei Yang, Jinlin Liu
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is characterized by recurrent episodes of inflammation with fever, abdominal pain, chest pain, rash, myalgia, arthralgia, conjunctivitis, and periorbital edema. This condition is a rare autosomal dominant disease that is strongly associated with heterozygous mutations in the tumor necrosis factor (TNF) receptor super family 1A (TNFRSF1A) gene. This condition is believed to be more common in Western countries than in Asian countries, and the AA amyloidosis rate for European countries is estimated to be 10%...
February 15, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29449351/regional-variation-and-predictors-of-over-registration-in-english-primary-care-in-2014-a-spatial-analysis
#6
Patrick Burch, Tim Doran, Evangelos Kontopantelis
BACKGROUND: There are more people registered with a general practice in England than are estimated to be resident in the country. The reasons behind this are not fully understood. We investigated the levels of over-registration (or under-registration) in English primary care, their regional variability and their association with population and geographical characteristics. METHODS: This was a cross-sectional study using mid-year population estimates for 2014 and general practice populations for the same year...
February 15, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29448966/exosomes-taken-up-by-neurons-hijack-the-endosomal-pathway-to-spread-to-interconnected-neurons
#7
Juan Carlos Polanco, Chuanzhou Li, Nela Durisic, Robert Sullivan, Jürgen Götz
In Alzheimer disease and related disorders, the microtubule-associated protein tau aggregates and forms cytoplasmic lesions that impair neuronal physiology at many levels. In addition to affecting the host neuron, tau aggregates also spread to neighboring, recipient cells where the misfolded tau aggregates, in a manner similar to prions, actively corrupt the proper folding of soluble tau, and thereby impair cellular functions. One vehicle for the transmission of tau aggregates are secretory nanovesicles known as exosomes...
February 15, 2018: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29448801/orientation-dependent-imaging-of-electronically-excited-quantum-dots
#8
Duc Nguyen, Joshua J Goings, Huy A Nguyen, Joseph Lyding, Xiaosong Li, Martin Gruebele
We previously demonstrated that we can image electronic excitations of quantum dots by single-molecule absorption scanning tunneling microscopy (SMA-STM). With this technique, a modulated laser beam periodically saturates an electronic transition of a single nanoparticle, and the resulting tunneling current modulation ΔI(x 0 , y 0 ) maps out the SMA-STM image. In this paper, we first derive the basic theory to calculate ΔI(x 0 , y 0 ) in the one-electron approximation. For near-resonant tunneling through an empty orbital "i" of the nanostructure, the SMA-STM signal is approximately proportional to the electron density φ i x 0 ,y 0 2 of the excited orbital in the tunneling region...
February 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29448782/pressure-control-in-interfacial-systems-atomistic-simulations-of-vapor-nucleation
#9
S Marchio, S Meloni, A Giacomello, C Valeriani, C M Casciola
A large number of phenomena of scientific and technological interest involve multiple phases and occur at constant pressure of one of the two phases, e.g., the liquid phase in vapor nucleation. It is therefore of great interest to be able to reproduce such conditions in atomistic simulations. Here we study how popular barostats, originally devised for homogeneous systems, behave when applied straightforwardly to heterogeneous systems. We focus on vapor nucleation from a super-heated Lennard-Jones liquid, studied via hybrid restrained Monte Carlo simulations...
February 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29448746/nano-precipitation-and-hardening-of-die-quenched-6061-aluminum-alloy
#10
Hiroshi Utsunomiya, Koki Tada, Ryo Matsumoto, Katsumi Watanabe, Kenji Matsuda
Die quenching is applied to an age-hardenable aluminium alloys to obtain super-saturated solid solution. The application is advantageous because it can reduce number of manufacturing processes, and may increase strength by strain aging. If die quenching is realized in forging as well as sheet forming, it may widen industrial applicability further. In this study, Al-Mg-Si alloy AA6061 8 mm-thick billets were reduced 50% in height without cracks by die-quench forging. Supersaturated solid solution was successfully obtained...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448264/clinical-appraisal-of-the-wam-x-super-quick-post-and-core-removal-device
#11
Lisa Friedlander, Cauris Couvrechel, Cyril Perez, Bruno Tavernier
This report describes an innovative technique to remove post-and-core restorations. The WAM'X Super Quick post removal device permits a secure mechanical traction technique that can adapt to variable root angulations. Pivoting prongs mounted on forceps allow post removal while preserving the ferrule effect to improve resistance to fractures.
February 15, 2018: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29447383/super-resolution-imaging-identifies-parp1-and-the-ku-complex-acting-as-dna-double-strand-break-sensors
#12
Guang Yang, Chao Liu, Shih-Hsun Chen, Muzaffer A Kassab, J Damon Hoff, Nils G Walter, Xiaochun Yu
DNA double-strand breaks (DSBs) are fatal DNA lesions and activate a rapid DNA damage response. However, the earliest stage of DSB sensing remains elusive. Here, we report that PARP1 and the Ku70/80 complex localize to DNA lesions considerably earlier than other DSB sensors. Using super-resolved fluorescent particle tracking, we further examine the relocation kinetics of PARP1 and the Ku70/80 complex to a single DSB, and find that PARP1 and the Ku70/80 complex are recruited to the DSB almost at the same time...
February 13, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29446701/endoscopic-excision-of-benign-facial-masses-in-children-a-review-of-outcomes
#13
Deshka Foster, Tiffany J Sinclair, Jordan S Taylor, Sanjeev Dutta, Hermann P Lorenz, Matias Bruzoni
PURPOSE: Benign masses of the eyebrow and forehead are common in pediatric patients and can result in facial asymmetry, discomfort, or super-infection. Excision is classically conducted via an incision directly over the mass, which can produce sub-optimal cosmesis. Recently, an endoscopic approach using pediatric brow-lift equipment has been adopted. We reviewed our center's experience with endoscopic removal of benign facial lesions and compared these cases with an equivalent series of open cases...
February 15, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29445565/super-resolution-community-detection-for-layer-aggregated-multilayer-networks
#14
Dane Taylor, Rajmonda S Caceres, Peter J Mucha
Applied network science often involves preprocessing network data before applying a network-analysis method, and there is typically a theoretical disconnect between these steps. For example, it is common to aggregate time-varying network data into windows prior to analysis, and the trade-offs of this preprocessing are not well understood. Focusing on the problem of detecting small communities in multilayer networks, we study the effects of layer aggregation by developing random-matrix theory for modularity matrices associated with layer-aggregated networks with N nodes and L layers, which are drawn from an ensemble of Erdős-Rényi networks with communities planted in subsets of layers...
July 2017: Physical Review. X
https://www.readbyqxmd.com/read/29445446/down-regulation-of-mir-210-3p-encourages-chemotherapy-resistance-of-renal-cell-carcinoma-via-modulating-abcc1
#15
Songchao Li, Jinjian Yang, Jun Wang, Wansheng Gao, Yafei Ding, Yinghui Ding, Zhankui Jia
Background: ATP-binding cassette transporter super-family including ABCC1 and MDR-1 were involved in multi-drug resistance (MDR) of renal cell carcinoma (RCC) patients. Several miRNAs were confirmed to promote the MDR and the survival of tumor cells. Methods: The RCC cell lines Caki-2 with vinblastine-resistant (Caki-2/VBL) or doxorubicin-resistant (Caki-2/DOX) were constructed, respectively. The expressions of miR-210-3p, ABCC1 and MDR-1 protein were determined by qRT-PCR and Western blot assays...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29445221/remodeling-of-the-actin-spectrin-membrane-associated-periodic-skeleton-growth-cone-collapse-and-f-actin-decrease-during-axonal-degeneration
#16
Nicolas Unsain, Martin D Bordenave, Gaby F Martinez, Jalil Sami, Catalina von Bilderling, Federico M Barabas, Luciano A Masullo, Aaron D Johnstone, Philip A Barker, Bisbal Mariano, Fernando D Stefani, Alfredo O Cáceres
Axonal degeneration occurs in the developing nervous system for the appropriate establishment of mature circuits, and is also a hallmark of diverse neurodegenerative diseases. Despite recent interest in the field, little is known about the changes (and possible role) of the cytoskeleton during axonal degeneration. We studied the actin cytoskeleton in an in vitro model of developmental pruning induced by trophic factor withdrawal (TFW). We found that F-actin decrease and growth cone collapse (GCC) occur early after TFW; however, treatments that prevent axonal fragmentation failed to prevent GCC, suggesting independent pathways...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29445035/comparative-dynamics-of-microglial-and-glioma-cell-motility-at-the-infiltrative-margin-of-brain-tumours
#17
Joseph Juliano, Orlando Gil, Andrea Hawkins-Daarud, Sonal Noticewala, Russell C Rockne, Jill Gallaher, Susan Christine Massey, Peter A Sims, Alexander R A Anderson, Kristin R Swanson, Peter Canoll
Microglia are a major cellular component of gliomas, and abundant in the centre of the tumour and at the infiltrative margins. While glioma is a notoriously infiltrative disease, the dynamics of microglia and glioma migratory patterns have not been well characterized. To investigate the migratory behaviour of microglia and glioma cells at the infiltrative edge, we performed two-colour time-lapse fluorescence microscopy of brain slices generated from a platelet-derived growth factor-B (PDGFB)-driven rat model of glioma, in which glioma cells and microglia were each labelled with one of two different fluorescent markers...
February 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29444854/bet-bromodomain-proteins-regulate-enhancer-function-during-adipogenesis
#18
Jonathan D Brown, Zachary B Feldman, Sean P Doherty, Jaime M Reyes, Peter B Rahl, Charles Y Lin, Quanhu Sheng, Qiong Duan, Alexander J Federation, Andrew L Kung, Saptarsi M Haldar, Richard A Young, Jorge Plutzky, James E Bradner
Developmental transitions are guided by master regulatory transcription factors. During adipogenesis, a transcriptional cascade culminates in the expression of PPARγ and C/EBPα, which orchestrate activation of the adipocyte gene expression program. However, the coactivators controlling PPARγ and C/EBPα expression are less well characterized. Here, we show the bromodomain-containing protein, BRD4, regulates transcription of PPARγ and C/EBPα. Analysis of BRD4 chromatin occupancy reveals that induction of adipogenesis in 3T3L1 fibroblasts provokes dynamic redistribution of BRD4 to de novo super-enhancers proximal to genes controlling adipocyte differentiation...
February 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29444564/bio-inspired-edible-super-hydrophobic-interface-for-reducing-residual-liquid-food
#19
Yao Li, Jingran Bi, Siqi Wang, Tan Zhang, Xiaomeng Xu, Haitao Wang, Shasha Cheng, Bei-Wei Zhu, Mingqian Tan
Significant wastage of residual liquid food, such as milk, yogurt, and honey, in food container has attracted great attention. In this work, a bio-inspired edible super-hydrophobic interface was fabricated using the FDA-approved and edible honeycomb wax, arabic gum, and gelatin by a simple and low-cost method. The bio-inspired edible super-hydrophobic interface showed multiscale structures, which were similar to that of lotus leaf surface. This bio-inspired edible super-hydrophobic interface displayed high contact angles for a variety of liquid foods and the residue of liquid foods could be effectively reduced using the bio-inspired interface...
February 14, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29444440/measuring-integrin-conformational-change-on-the-cell-surface-with-super-resolution-microscopy
#20
Travis I Moore, Jesse Aaron, Teng-Leong Chew, Timothy A Springer
We use super-resolution interferometric photoactivation and localization microscopy (iPALM) and a constrained photoactivatable fluorescent protein integrin fusion to measure the displacement of the head of integrin lymphocyte function-associated 1 (LFA-1) resulting from integrin conformational change on the cell surface. We demonstrate that the distance of the LFA-1 head increases substantially between basal and ligand-engaged conformations, which can only be explained at the molecular level by integrin extension...
February 13, 2018: Cell Reports
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