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https://www.readbyqxmd.com/read/28448243/the-patient-experience-of-illness-treatment-and-change-during-intensive-community-treatment-for-severe-anorexia-nervosa
#1
Julia Hannon, Lindsey Eunson, Calum Munro
This study explores experiences of intensive community treatment, illness, and change among patients with severe anorexia nervosa (sAN), particularly seeking to understand the processes involved in change and inability to change. A qualitative design with purposive semi-stratified sampling, using semi-structured interviews and interpretive phenomenological analysis, investigated in detail the experiences of five participants. Participants all had sAN at the start of treatment and represented a spectrum of outcomes from deterioration to full recovery...
April 27, 2017: Eating Disorders
https://www.readbyqxmd.com/read/28448115/high-temperature-superconductivity-in-boron-doped-q-carbon
#2
Anagh Bhaumik, Ritesh Sachan, Jagdish Narayan
We report high-temperature superconductivity in B-doped amorphous quenched carbon (Q-carbon). This phase is formed after nanosecond laser melting of B-doped amorphous carbon films in a super undercooled state and followed by rapid quenching. Magnetic susceptibility measurements show the characteristics of type-II Bardeen-Cooper-Schrieffer superconductivity with a superconducting transition temperature (Tc) of 36.0±0.5 K for 17.0±1.0 atomic percent boron concentration. This value is significantly higher than the best experimentally reported Tc of 11 K for crystalline B-doped diamond...
April 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/28448005/open-source-single-particle-analysis-for-super-resolution-microscopy-with-virusmapper
#3
Robert D M Gray, Jason Mercer, Ricardo Henriques
Super-resolution fluorescence microscopy is currently revolutionizing cell biology research. Its capacity to break the resolution limit of around 300 nm allows for the routine imaging of nanoscale biological complexes and processes. This increase in resolution also means that methods popular in electron microscopy, such as single-particle analysis, can readily be applied to super-resolution fluorescence microscopy. By combining this analytical approach with super-resolution optical imaging, it becomes possible to take advantage of the molecule-specific labeling capacity of fluorescence microscopy to generate structural maps of molecular elements within a metastable structure...
April 9, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447085/studying-structure-and-dynamics-of-self-assembled-peptide-nanostructures-using-fluorescence-and-super-resolution-microscopy
#4
Sílvia Pujals, Kai Tao, Adrià Terradellas, Ehud Gazit, Lorenzo Albertazzi
Understanding the formation and properties of self-assembled peptide nanostructures is the basis for the design of new architectures for various applications. Here we show the potential of fluorescence and super resolution imaging to unveil the structural and dynamic features of peptide nanofibers with high spatiotemporal resolution.
April 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28446439/pax3-foxo1-establishes-myogenic-super-enhancers-and-confers-bet-bromodomain-vulnerability
#5
Berkley E Gryder, Marielle E Yohe, Hsien-Chao Chou, Xiaohu Zhang, Joana Marques, Marco Wachtel, Beat Schaefer, Nirmalya Sen, Young K Song, Alberto Gualtieri, Silvia Pomella, Rossella Rota, Abigail Cleveland, Xinyu Wen, Sivasish Sindiri, Jun S Wei, Frederic G Barr, Sudipto Das, Thorkell Andresson, Rajarshi Guha, Madhu Lal-Nag, Marc Ferrer, Jack F Shern, Keji Zhao, Craig J Thomas, Javed Khan
Alveolar rhabdomyosarcoma is a life-threatening myogenic cancer of children and adolescent young adults, driven primarily by the chimeric transcription factor PAX3-FOXO1 (P3F). The mechanisms by which P3F dysregulates chromatin are unknown. We find P3F reprograms the cis-regulatory landscape by inducing (de novo) super enhancers (SEs). P3F uses SEs to setup auto-regulatory loops in collaboration with master transcription factors MYOG, MYOD and MYCN. This myogenic SE circuitry is consistent across cell lines and primary tumors...
April 26, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28446263/spectrum-and-predictors-of-refractory-status-epilepticus-in-a-developing-country
#6
Deepanshu Dubey, Sanjeev K Bhoi, Jayantee Kalita, Usha K Misra
OBJECTIVE: Refractory status epilepticus (RSE) can influence the outcome of status epilepticus (SE). In the present study, we report the aetiology and predictors of outcomes of RSE in a developing country. METHODS: This is a prospective hospital-based study of SE patients (continuous seizures for five minutes or more). Those who had SE persisting after two antiepileptic drugs were defined as having RSE. We present the demographic information, duration, and type of SE, and we note its severity using the status epilepticus severity score (STESS), its aetiology, comorbidities and imaging findings...
April 27, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/28445958/repressing-cd147-is-a-novel-therapeutic-strategy-for-malignant-melanoma
#7
REVIEW
Xing Hu, Juan Su, Youyou Zhou, Xiaoyun Xie, Cong Peng, Zhimin Yuan, Xiang Chen
CD147/basigin, a transmembrane protein, is a member of the immunoglobulin super family. Accumulating evidence has revealed the role of CD147 in the development and progression of various cancers, including malignant melanoma (MM). MM is a malignancy of pigment-producing cells that causes the greatest number of skin cancer-related deaths worldwide. CD147 is overexpressed in MM and plays an important role in cell viability, apoptosis, proliferation, invasion, and metastasis, probably by mediating vascular endothelial growth factor (VEGF) production, glycolysis, and multi-drug resistance (MDR)...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445806/patient-engagement-at-the-margins-health-care-providers-assessments-of-engagement-and-the-structural-determinants-of-health-in-the-safety-net
#8
Mark D Fleming, Janet K Shim, Irene Yen, Ariana Thompson-Lastad, Sara Rubin, Meredith Van Natta, Nancy J Burke
Increasing "patient engagement" has become a priority for health care organizations and policy-makers seeking to reduce cost and improve the quality of care. While concepts of patient engagement have proliferated rapidly across health care settings, little is known about how health care providers make use of these concepts in clinical practice. This paper uses 20 months of ethnographic and interview research carried out from 2015 to 2016 to explore how health care providers working at two public, urban, safety-net hospitals in the United States define, discuss, and assess patient engagement...
April 20, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28445761/live-cell-super-resolution-reveals-f-actin-and-plasma-membrane-dynamics-at-the-t-cell-synapse
#9
George W Ashdown, Garth L Burn, David J Williamson, Elvis Pandžić, Ruby Peters, Michael Holden, Helge Ewers, Lin Shao, Paul W Wiseman, Dylan M Owen
The cortical actin cytoskeleton has been shown to be critical for the reorganization and heterogeneity of plasma membrane components of many cells, including T cells. Building on previous studies at the T cell immunological synapse, we quantitatively assess the structure and dynamics of this meshwork using live-cell superresolution fluorescence microscopy and spatio-temporal image correlation spectroscopy. We show for the first time, to our knowledge, that not only does the dense actin cortex flow in a retrograde fashion toward the synapse center, but the plasma membrane itself shows similar behavior...
April 25, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28445475/grhl3-binding-and-enhancers-rearrange-as-epidermal-keratinocytes-transition-between-functional-states
#10
Rachel Herndon Klein, Ziguang Lin, Amelia Soto Hopkin, William Gordon, Lam C Tsoi, Yun Liang, Johann E Gudjonsson, Bogi Andersen
Transcription factor binding, chromatin modifications and large scale chromatin re-organization underlie progressive, irreversible cell lineage commitments and differentiation. We know little, however, about chromatin changes as cells enter transient, reversible states such as migration. Here we demonstrate that when human progenitor keratinocytes either differentiate or migrate they form complements of typical enhancers and super-enhancers that are unique for each state. Unique super-enhancers for each cellular state link to gene expression that confers functions associated with the respective cell state...
April 26, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28445032/superstretchable-nacre-mimetic-graphene-poly-vinyl-alcohol-composite-film-based-on-interfacial-architectural-engineering
#11
Nifang Zhao, Miao Yang, Qian Zhao, Weiwei Gao, Tao Xie, Hao Bai
Through designing hierarchical structures, particularly optimizing the chemical and architectural interactions at its inorganic/organic interface, nacre has achieved an excellent combination of contradictory mechanical properties such as strength and toughness, which is highly demanded yet difficult to achieve by most synthetic materials. Most techniques applied to develop nacre-mimetic composites have been focused on mimicking the "brick-and-mortar" structure, but the interfacial architectural features, especially the asperities and mineral bridges of "bricks", have been rarely concerned, which are of equal importance for enhancing mechanical properties of nacre...
April 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/28444700/fluorescence-lifetime-imaging-and-super-resolution-microscopies-shed-light-on-the-directed-and-self-assembly-of-functional-porphyrins-onto-carbon-nanotubes-and-flat-surfaces
#12
Boyang Mao, David González Calatayud, Vincenzo Mirabello, Haobo Ge, Benjamin J Hodges, Robert M J Jacobs, Ashley M Shepherd, José Alberto Ribeiro Martins, Navaratnarajah Kuganathan, Jorge Bernardino De La Serna, Stanley W Botchway, Sofia Ioana Pascu
Two new routes to functionalized SWNTs have been established using a bulky Zn(II)-porphyrin featuring thiolate groups at the periphery. We probed the optical properties of this Zinc(II)-substituted, bulky aryl porphyrin and those of the corresponding new nano-composites with single walled carbon nanotube (SWNTs) and coronene, as a model for graphene. We report hereby on: (i) the supramolecular interactions between the pristine SWNTs and Zn(II)-porphyrin by virtue of π-π stacking, and (ii) a novel covalent binding strategy based on the Bingel reaction...
April 25, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28444194/evolution-of-the-3r-myb-gene-family-in-plants
#13
Guanqiao Feng, J Gordon Burleigh, Edward L Braun, Wenbin Mei, W Brad Barbazuk
Plant 3R-MYB transcription factors are an important subgroup of the MYB super family in plants; however, their evolutionary history and functions remain poorly understood. We identified 225 3R-MYB proteins from 65 plant species, including algae and all major lineages of land plants. Two segmental duplication events preceding the common ancestor of angiosperms have given rise to three subgroups of the 3R-MYB proteins. Five conserved introns in the domain region of the 3R-MYB genes were identified, which arose through a step-wise pattern of intron gain during plant evolution...
April 20, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28444133/increased-collagen-within-the-transverse-tubules-in-human-heart-failure
#14
David J Crossman, Xin Shen, Mia Jüllig, Michelle Munro, Yufeng Hou, Martin Middleditch, Darshan Shrestha, Amy Li, Sean Lal, Cristobal G Dos Remedios, David Baddeley, Peter N Ruygrok, Christian Soeller
Aims: In heart failure transverse-tubule (t-tubule) remodelling disrupts calcium release, and contraction. T-tubules in human failing hearts exhibit increased labelling by wheat germ agglutinin (WGA), a lectin that binds to the dystrophin-associated glycoprotein complex. We hypothesized changes in this complex may explain the increased WGA labelling and contribute to t-tubule remodelling in the failing human heart. In this study we sought to identify the molecules responsible for this increased WGA labelling...
April 20, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28443904/na3v2-po4-3-nitrogen-sulfur-codoped-3d-porous-carbon-enabling-ultra-long-cycle-life-sodium-ion-batteries
#15
Yu Jiang, Haochuan Zhang, Hai Yang, Zhenyu Qi, Yan Yu
Na3V2(PO4)3 (NVP) is regarded as a promising cathode material for sodium ion batteries (NIBs) because of its 3D open structure suitable for Na insertion/extraction and high energy density. However, the NVP suffers from poor electrical conductivity, which restricts the rate performance and the long cycle performance of the NVP for NIBs. Here, the NVP particles embedded in the N,S co-doped 3D porous carbon matrix (denoted as NVP@3D-NSC) were prepared by a facile process. The NVP@3D-NSC can deliver high specific discharge capacities at high rates (54 mA h g(-1) at 80 C)...
April 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/28443827/three-dimensional-magnetic-interactions-in-quasi-two-dimensional-pdas-sub-2-sub-o-sub-6-sub
#16
Zhiying Zhao, Yan Wu, Huibo Cao, Haidong Zhou, Jiaqiang Yan
Millimeter-sized PdAs<sub>2</sub>O<sub>6</sub> single crystals are grown using the vapor transport technique. The magnetic order at T<sub>N</sub>=140K is studied by measuring magnetic properties, specific heat, and neutron single crystal diffraction. The anisotropic magnetic susceptibility and a metamagnetic transition observed in magnetic fields above 2,kOe suggest that the magnetic moment lies in the <i>ab</i> plane, consistent with the magnetic structure determined by neutron single crystal diffraction...
April 26, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28443513/the-gastrointestinal-dysmotility-and-infections-in-systemic-sclerosis-a-real-world-scenario
#17
Shefali Khanna Sharma, M B Adarsh, Saroj K Sinha, Anish Bhattacharya, Satyavati Rana, Surjit Singh, Varun Dhir
INTRODUCTION: Systemic Sclerosis is known to involve the gastrointestinal system and can lead to multitude of problems predominantly affecting the GI motility. METHODS: It was a prospective, observational, single centre study of fifty consecutive patients with SSc who presented to rheumatology clinic. Gut score was assessed using UCLA SCTC GIT 2.0 questionnaire. 35 patients underwent esophago- gastro duodenoscopy(UGIE), 31 underwent esophageal manometry, 37 underwent lactulose breath test to assess orocaecal transit time (OCTT) and glucose breath test for detecting small intestinal bacterial overgrowth (SIBO) and 36 underwent gastric emptying scintigraphy to measure gastric emptying time...
April 25, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28442054/when-colocation-is-not-enough-a-case-study-of-general-practitioner-super-clinics-in-australia
#18
Riki Lane, Grant Russell, Elizabeth A Bardoel, Jenny Advocat, Nicholas Zwar, P Gawaine Powell Davies, Mark F Harris
Developed nations are implementing initiatives to transform the delivery of primary care. New models have been built around multidisciplinary teams, information technology and systematic approaches for chronic disease management (CDM). In Australia, the General Practice Super Clinic (GPSC) model was introduced in 2010. A case study approach was used to illustrate the development of inter-disciplinary CDM over 12 months in two new, outer urban GPSCs. A social scientist visited each practice for two 3-4-day periods...
April 2017: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/28441654/gastric-ulcer-hemorrhage-a-potential-life-threatening-complication-of-intragastric-balloon-treatment-of-obesity
#19
Aleksandra Mojkowska, Stefan Gazdzinski, Mariusz Fraczek, Mariusz Wyleżoł
BACKGROUND: Some morbidly obese patients do not qualify for bariatric surgery due to general health contraindications. Intragastric balloon treatment might be a therapeutic option in the above-mentioned cases. It can prime super-obese patients with end-stage disease for bariatric surgery. As a neoadjuvant therapy before surgery, it leads to a downstage of the disease by preliminary weight reduction, to an improvement in general health and, in summary, to a reduction of the perioperative risk...
April 26, 2017: Obesity Facts
https://www.readbyqxmd.com/read/28441489/a-comparison-of-gasoline-direct-injection-gdi-and-port-fuel-injection-pfi-vehicle-emissions-emission-certification-standards-cold-start-secondary-organic-aerosol-formation-potential-and-potential-climate-impacts
#20
Georges Saliba, Rawad Saleh, Yunliang Zhao, Albert A Presto, Andrew T Lambe, Bruce Frodin, Satya Sardar, Hector Maldonado, Christine Maddox, Andrew A May, Greg T Drozd, Allen H Goldstein, Lynn M Russell, Fabian P Hagen, Allen L Robinson
Recent increases in the Corporate Average Fuel Economy standards have led to widespread adoption of vehicles equipped with gasoline direct injection (GDI) engines. Changes in engine technologies can alter emissions. To quantify these effects, we measured gas- and particle-phase emissions from eighty-two light duty gasoline vehicles recruited from the California in-use fleet tested on a chassis dynamometer using the cold-start unified cycle. The fleet included 15 GDI vehicles, including 8 GDIs certified to the most stringent emissions standard, super-ultra-low-emission vehicles (SULEV)...
April 25, 2017: Environmental Science & Technology
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