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https://www.readbyqxmd.com/read/28545201/treatment-experiences-of-women-with-reproductive-cancers-in-odisha-india-a-qualitative-exploration-of-enablers-and-barriers
#1
Sanghamitra Pati, Abhimanyu Singh Chauhan, Sandeep Mahapatra, Sabita Nayak, Sukdev Nayak, David Weller
Introduction: Cancer continues to be a major menace to our Indian society notwithstanding significant progress in diagnosis and treatment. In India cancer mortality rates in women are high compared to other countries, despite efforts to improve survival through the development of effective detection techniques and increased numbers of viable treatment options. Indian women’s advanced stage of disease at diagnosis is largely attributable to delay in seeking treatment. The present qualitative inquiry was conducted with the aim of capturing the treatment experiences of patients with gynecology cancer at a tertiary care hospital and understanding the barriers, enablers, stress and apprehension they experience during the treatment phases...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28545132/proteomics-investigation-of-oscc-specific-salivary-biomarkers-in-a-hungarian-population-highlights-the-importance-of-identification-of-population-tailored-biomarkers
#2
Éva Csősz, Péter Lábiscsák, Gergő Kalló, Bernadett Márkus, Miklós Emri, Adrienn Szabó, Ildikó Tar, József Tőzsér, Csongor Kiss, Ildikó Márton
Oral squamous cell carcinoma (OSCC) accounting for about 90% of malignant oral lesions is the 6th most common malignancy worldwide. Diagnostic delay may contribute to dismal survival rate therefore, there is a need for developing specific and sensitive biomarkers to improve early detection. Hungarian population occupies the top places of statistics regarding OSCC incidence and mortality figures therefore, we aimed at finding potential salivary protein biomarkers suitable for the Hungarian population. In this study we investigated 14 proteins which were previously reported as significantly elevated in saliva of patients with OSCC...
2017: PloS One
https://www.readbyqxmd.com/read/28544945/longitudinal-association-between-diabetes-and-cognitive-decline-the-national-health-and-aging-trends-study
#3
Alexandra M V Wennberg, Clinton E Hagen, Rebecca F Gottesman, Vadim Zipunnikov, Christopher N Kaufmann, Marilyn S Albert, George W Rebok, Judith D Kasper, Adam P Spira
Type II diabetes mellitus (DM) is associated with increased risk of dementia; however, few studies have examined the longitudinal association between DM and cognitive outcomes in large nationally representative cohorts. We investigated these associations in 7605 participants enrolled in the National Health and Aging Trends Study, a nationally representative prospective study of Medicare beneficiaries ≥65, from 2011 to 2015. Participants or proxy respondents reported DM and dementia diagnosis, and participants completed immediate and delayed recall word list learning tests and the Clock Drawing Test...
May 16, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28544813/nursing-diagnosis-risk-for-delayed-surgical-recovery-00246-concept-clarification-and-definition-of-empirical-referents
#4
Simone Martins Rembold, Rosimere Ferreira Santana, Priscilla Alfradique de Souza, Sócrates Miranda de Oliveira Xavier Schwartz
PURPOSE: To clarify the concept of risk for delayed surgical recovery (00246) and to define the empirical referents for identification of predictive factors of delay in recovery. METHOD: A concept analysis was developed based on the eight steps proposed by Walker and Avant. RESULTS: Defining attributes were determined and antecedents and consequents identified. Cases were proposed cases and empirical referents established. CONCLUSION: The results provided evidences and instrumentalize empirical referents, which may support an accurate nursing diagnosis...
May 23, 2017: International Journal of Nursing Knowledge
https://www.readbyqxmd.com/read/28544538/cornelia-de-lange-syndrome-to-diagnose-or-not-to-diagnose-in-utero
#5
REVIEW
Laura Avagliano, Gaetano Pietro Bulfamante, Valentina Massa
Cornelia de Lange syndrome (CdLS) is an inherited condition with a wide spectrum of phenotypic anomalies, consisting mainly of growth impairment, multi-organ abnormalities, and neurocognitive delay. Clinical diagnostic criteria after birth are well defined, whereas when to suspect the syndrome during intrauterine life still remains undefined. This review summarizes the main possible prenatal findings in CdLS, suggesting that a skilled ultrasound scan in cases of intrauterine growth restriction associated with other fetal abnormalities may improve the chance of prenatal diagnosis of CdLS, especially in families known to be at high risk...
May 22, 2017: Birth Defects Res
https://www.readbyqxmd.com/read/28544470/patients-help-seeking-experiences-and-delaying-in-breast-cancer-diagnosis-a-qualitative-study
#6
Mariko Oshiro, Midori Kamizato
AIM: To identify the influencing factors in help-seeking behavior by comparing delayers with non-delayers in Japanese female patients with breast cancer. METHODS: This is a descriptive qualitative study. A total of 21 female patients with breast cancer (nine delayers and 12 non-delayers) who were at least 3 months to 5 years postdiagnosis were recruited from two hospitals in Okinawa, Japan. Semistructured interviews were carried out and the results were analyzed by using a qualitative inductive approach...
May 23, 2017: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/28544294/factors-affecting-the-timeliness-and-adequacy-of-haematuria-assessment-in-bladder-cancer-a-systematic-review
#7
REVIEW
Brian Ngo, Marlon Perera, Nathan Papa, Damien Bolton, Shomik Sengupta
OBJECTIVES: To review the literature to identify factors affecting haematuria assessment in bladder cancer. METHODS: We performed a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Publications indexed in EMBASE and Medline (PubMed) in March 2016 were searched, using the keywords 'hematuria', 'urinary bladder neoplasm(s)' and 'bladder tumor'. Studies evaluating the timeliness and adequacy of haematuria assessment in the context of bladder cancer were included...
May 2017: BJU International
https://www.readbyqxmd.com/read/28544121/is-a-delay-in-the-diagnosis-of-bipolar-disorder-inevitable
#8
Kristina Fritz, Alex M T Russell, Christine Allwang, Sandy Kuiper, Lisa Lampe, Gin S Malhi
OBJECTIVE: A diagnosis of bipolar disorder (BD) is often preceded by an initial diagnosis of depression, creating a delay in the accurate diagnosis and treatment of BD. Although previous research has focused on predictors of a diagnosis change from depression to BD, the research on this delay in diagnosis is sparse. Therefore, the present study examined the time taken to make a BD diagnosis following an initial diagnosis of major depressive disorder in order to further understand the patient characteristics and psychological factors that may explain this delay...
May 22, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28543095/psychological-mechanisms-and-the-ups-and-downs-of-personal-recovery-in-bipolar-disorder
#9
Alyson L Dodd, Barbara Mezes, Fiona Lobban, Steven H Jones
BACKGROUND: Personal recovery is recognized as an important outcome for individuals with bipolar disorder (BD) and is distinct from symptomatic and functional recovery. Recovery-focused psychological therapies show promise. As with therapies aiming to delay relapse and improve symptoms, research on the psychological mechanisms underlying recovery is crucial to inform effective recovery-focused therapy. However, empirical work is limited. This study investigated whether negative beliefs about mood swings and self-referent appraisals of mood-related experiences were negatively associated with personal recovery...
May 22, 2017: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28542677/association-of-previous-clinical-breast-examination-with-reduced-delays-and-earlier-stage-breast-cancer-diagnosis-among-women-in-peru
#10
Anya Romanoff, Tara Hayes Constant, Kay M Johnson, Manuel Cedano Guadiamos, Ana María Burga Vega, Joseph Zunt, Benjamin O Anderson
Importance: Mammographic screening is impractical in most of the world where breast cancers are first identified based on clinical signs and symptoms. Clinical breast examination may improve early diagnosis directly by finding breast cancers at earlier stages or indirectly by heightening women's awareness of breast health concerns. Objective: To investigate factors that influence time to presentation and stage at diagnosis among patients with breast cancer to determine whether history of previous clinical breast examination is associated with earlier presentation and/or earlier cancer stage at diagnosis...
May 25, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28542336/does-ngal-reduce-costs-a-cost-analysis-of-urine-ngal-ungal-serum-creatinine-scr-for-acute-kidney-injury-aki-diagnosis
#11
Amay Parikh, John A Rizzo, Pietro Canetta, Catherine Forster, Meghan Sise, Omar Maarouf, Eugenia Singer, Antje Elger, Saban Elitok, Kai Schmidt-Ott, Jonathon Barasch, Thomas L Nickolas
INTRODUCTION: Urine neutrophil gelatinase-associated lipocalin (uNGAL) is a sensitive and specific diagnostic test for acute kidney injury (AKI) in the Emergency Department (ED), but its economic impact has not been investigated. We hypothesized that uNGAL used in combination with serum creatinine (sCr) would reduce costs in the management of AKI in patients presenting to the ED in comparison to using sCr alone. MATERIALS AND METHODS: A cost simulation model was developed for clinical algorithms to diagnose AKI based on sCr alone vs...
2017: PloS One
https://www.readbyqxmd.com/read/28542255/detection-of-mycobacterium-tuberculosis-from-the-stool-of-hiv-sero-positive-individuals-suspected-of-pulmonary-tuberculosis
#12
Gizaw E Abaye, Tamrat Abebe, Adane Worku, Debela Tolessa, Gobena Ameni, Adane Mihret
BACKGROUND: The impact of tuberculosis (TB) is exacerbated in Africa because of the human immunodeficiency virus (HIV) pandemic. Pulmonary tuberculosis (PTB) diagnosis is difficult in HIV-infected patients and negative sputum results are more common which leads to diagnostic delay and increases morbidity and mortality. Extra-pulmonary samples such as stool may be easier to obtain and our approach may therefore significantly improve PTB detection in people living with HIV. OBJECTIVE: To detect Mycobacterium tuberculosis from the stool of HIV sero-positive individuals suspected of pulmonary TB...
2017: PloS One
https://www.readbyqxmd.com/read/28542123/malaria-surveillance-united-states-2014
#13
Kimberly E Mace, Paul M Arguin
PROBLEM/CONDITION: Malaria in humans is caused by intraerythrocytic protozoa of the genus Plasmodium. These parasites are transmitted by the bite of an infective female Anopheles mosquito. The majority of malaria infections in the United States occur among persons who have traveled to regions with ongoing malaria transmission. However, malaria is occasionally acquired by persons who have not traveled out of the country through exposure to infected blood products, congenital transmission, laboratory exposure, or local mosquitoborne transmission...
May 26, 2017: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/28541957/the-cutting-edge-of-retinopathy-of-prematurity-care-expanding-the-boundaries-of-diagnosis-and-treatment
#14
Yoshihiro Yonekawa, Benjamin J Thomas, Aristomenis Thanos, Bozho Todorich, Kimberly A Drenser, Michael T Trese, Antonio Capone
PURPOSE: To discuss the latest advances and controversies in the diagnosis and care of infants with retinopathy of prematurity (ROP). METHODS: Literature review. RESULTS: Retinopathy of prematurity remains a major global issue. Industrialized nations now treat profoundly premature infants with posterior and aggressive disease, and middle-income nations are experiencing ROP epidemics. Remote digital imaging may address the decreasing ratio of ROP providers to premature infants, in addition to improving patient care...
May 24, 2017: Retina
https://www.readbyqxmd.com/read/28541877/erythromelalgia-involving-the-face
#15
Rachel R Gilmore, Danielle S Applebaum, Jessica L Parsons, Sylvia Hsu
Erythromelalgia is a rare disorder characterized by burning pain, erythema, and increased temperature typically involving the distal extremities. Although it can progress to involve the face, erythromelalgia presenting only on the face is particularly rare. This disorder is often misdiagnosed when it presents on the extremities and is even more likely to be misdiagnosed when presenting only on the face, delaying appropriate treatment and causing considerable frustration for the patient. We report a case of a 26-year-old woman with erythromelalgia that involved only the face for a number of years and was treated unsuccessfully as rosacea, seborrheic dermatitis, and contact dermatitis...
April 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28541766/the-clinical-utility-of-vestibular-autorotation-test-in-patients-with-vestibular-migraine
#16
Yogun Thungavelu, Wei Wang, Peng Lin, Taisheng Chen, Kaixu Xu
OBJECTIVE: To investigate the characteristics and clinical utility of vestibular autorotation test (VAT) in patients with vestibular migraine. METHODS: This study included two groups, an experimental group (441 patients) and a control group (65 healthy subjects). Both groups undertook VAT; the parameters evaluated were horizontal gain/phase, vertical gain/phase and asymmetry. The differences in VAT results between the two groups were investigated. RESULTS: There were no statistical differences between the VAT data of the control group when compared to the reference value from the manufacturer (p > ...
May 25, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28541591/infective-endocarditis-cinderella-in-cardiology
#17
Amit Kaura, Dorota Dworakowska, Rafal Dworakowski
Infective endocarditis (IE) is uncommon, however, the incidence is on the rise [1]. Despite improvements in its management, infective endocarditis (IE) is associated with significant short- and long-term morbidity and mortality [2]. A definitive diagnosis of IE may be challenging and is often delayed due to the highly variable and non-specific symptoms at patient presentation, alongside limited availability of specialist services [3]. In addition to IE remaining a diagnostic challenge, the decisions about the treatment modality (medical vs surgical) and the timing of potential valve surgery are demanding, despite established national and international guidelines [4]...
May 25, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28541497/improved-survival-with-decreased-wait-time-to-surgery-in-glioblastoma-patients-presenting-with-seizure
#18
Patrick M Flanigan, Arman Jahangiri, Ruby Kuang, Albert Truong, Sarah Choi, Alvin Chou, Jonathan W Rick, Susan M Chang, Annette M Molinaro, Michael W McDermott, Mitchel S Berger, Manish K Aghi
BACKGROUND: Preoperative seizure is reported to confer favorable prognosis in glioblastoma patients, but studies to date have not investigated how broadly applicable seizure is as a prognostic factor. OBJECTIVE: To investigate if prompter surgical intervention affects the relationship between preoperative seizure and prognosis in glioblastoma patients, focusing on the development of tumor growth and/or additional preoperative symptoms after seizure. METHODS: Retrospective analysis of 443 patients (mean age = 60...
May 24, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28540974/neuroendocrine-neoplasms-of-the-small-intestine-and-appendix-management-guidelines-recommended-by-the-polish-network-of-neuroendocrine-tumours
#19
Tomasz Bednarczuk, Marek Bolanowski, Anna Zemczak, Agata Bałdys-Waligórska, Jolanta Blicharz-Dorniak, Agnieszka Boratyn-Nowicka, Małgorzata Borowska, Andrzej Cichocki, Jarosław B Ćwikła, Massimo Falconi, Wanda Foltyn, Daria Handkiewicz-Junak, Alicja Hubalewska-Dydejczyk, Barbara Jarząb, Roman Junik, Dariusz Kajdaniuk, Grzegorz Kamiński, Agnieszka Kolasińska-Ćwikła, Aldona Kowalska, Robert Król, Leszek Królicki, Jolanta Kunikowska, Katarzyna Kuśnierz, Paweł Lampe, Dariusz Lange, Anna Lewczuk-Myślicka, Andrzej Lewiński, Michał Lipiński, Magdalena Londzin-Olesik, Bogdan Marek, Anna Nasierowska-Guttmejer, Ewa Nowakowska-Duława, Jakub Pałucki, Joanna Pilch-Kowalczyk, Violetta Rosiek, Marek Ruchała, Lucyna Siemińska, Anna Sowa-Staszczak, Teresa Starzyńska, Katarzyna Steinhof-Radwańska, Janusz Strzelczyk, Krzysztof Sworczak, Anhelli Syrenicz, Andrzej Szawłowski, Marek Szczepkowski, Ewa Wachuła, Wojciech Zajęcki, Wojciech Zgliczyński, Beata Kos-Kudła
This study presents the revised Polish guidelines regarding the management of patients suffering from neuroendocrine neoplasms (NENs) of the small intestine and appendix. The small intestine, especially the ileum, is the most common location for these neoplasms. Most are well differentiated and slow growing. Their symptoms may be atypical, which can result in delayed or accidental diagnosis. Appendicitis is usually the first manifestation of NEN in this location. Typical symptoms of carcinoid syndrome occur in approximately 20-30% of patients suffering from small intestinal NENs with distant metastases...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28540636/gm2-activator-deficiency-caused-by-a-homozygous-exon-2-deletion-in-gm2a
#20
Patricia L Hall, Regina Laine, John J Alexander, Arunkanth Ankala, Lisa A Teot, Hart G W Lidov, Irina Anselm
GM2 activator (GM2A) deficiency (OMIM 613109) is a rare lysosomal storage disorder, with onset typically in infancy or early childhood. Clinically, it is almost indistinguishable from Tay-Sachs disease (OMIM 272800) or Sandhoff disease (OMIM 268800); however, traditionally available biochemical screening tests will most likely reveal normal results. We report a 2-year-old male with initially normal development until the age of 9 months, when he presented with developmental delay and regression. Workup at that time was unrevealing; at 15 months, he had abnormal brain MRI findings and a cherry red spot on ophthalmological examination...
May 25, 2017: JIMD Reports
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