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https://www.readbyqxmd.com/read/29233079/a-diagnostic-approach-for-rodent-progressive-cardiomyopathy-and-like-lesions-in-toxicology-studies-up-to-28-days-in-the-sprague-dawley-rat-part-2-of-2
#1
James R Hailey, Beverly E Maleeff, Heath C Thomas, Gail Pearse, Jan C Klapwijk, Patrizia G Cristofori, Brian Berridge, Carie L Kimbrough, George A Parker, Daniel Morton, Susan Elmore, Jerry F Hardisty, Noel O Dybdal, David A Rehagen, James D Fikes, Martin Lamb, Kathleen Biddle, Bernard S Buetow, Vinicius Carreira, Abraham Nyska, Niraj K Tripathi, Heather C Workman, Jean-Guy Bienvenu, Ingrid Brees, James R Turk, Rick R Adler
To test the diagnostic approach described in part 1 of this article, 2 exercises were completed by pathologists from multiple companies/agencies. Pathologist's examination of whole slide image (WSI) heart sections from rats using personal diagnostic approaches (exercise #1) corroborated conclusions from study #1. Using the diagnostic approach described in part 1, these pathologists examined the same WSI heart sections (exercise #2) to determine whether that approach increased consistency of diagnosis of rodent progressive cardiomyopathy (PCM) lesions...
December 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/29222688/comparison-of-qualitative-and-quantitative-ct-and-mri-parameters-for-monitoring-of-longitudinal-spine-involvement-in-patients-with-multiple-myeloma
#2
M Horger, J Fritz, W M Thaiss, H Ditt, K Weisel, M Haap, Christopher Kloth
PURPOSE: To compare qualitative and quantitative computed tomography (CT) and magnetic resonance imaging (MRI) parameters for longitudinal disease monitoring of multiple myeloma (MM) of the axial skeleton. MATERIALS AND METHODS: We included 31 consecutive patients (17 m; mean age 59.20 ± 8.08 years) with MM, who underwent all baseline (n = 31) and at least one or more (n = 47) follow-up examinations consisting of multi-parametric non-enhanced whole-body MRI (WBMRI) and non-enhanced whole-body reduced-dose thin-section MDCT (NEWBMDCT) between 06/2013 and 09/2016...
December 8, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29221838/aneurysm-of-the-anomalous-splenic-artery-arising-from-superior-mesenteric-artery-treated-by-coil-embolization-a-report-of-two-cases-and-literature-review
#3
Shui-Lin Dong, Xiao Chen, Zhen-Xiao Tu, Xi Ai, Zhi-Wei Zhang, Yan Guan, Hong Chen, Jun Yang
OBJECTIVE: Aneurysm of splenic artery which arises from the superior mesenteric artery is a very rare condition. The aim of this study was to present our experience with two such patients treated by coil embolization. DESIGN: Case report. METHODS AND RESULTS: A 33-year-old man and a 61-year old woman were incidentally identified with aneurysms of the splenic artery which arose from the superior mesenteric artery. Endovascular therapy of coil embolization was chosen to treat the aneurysm...
December 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29221638/d-dimer-level-correlation-with-treatment-response-in-children-with-venous-malformations
#4
Yvonne Chi-Lun Leung, Michael Wai-Yip Leung, Shi-Da Yam, Judy Wing-Suet Hung, Clarence Sze-Wai Liu, Lap-Yan Chung, Man-Yee Tang, Hon-Shing Fung, Wai-Lun Poon, Nicholas Sih-Yin Chao, Kelvin Kam-Wing Liu
AIM: Localized intravascular coagulopathy is present in children with venous malformations (VMs) as evidenced by elevated D-dimer levels. Few studies have looked into the changes in D-dimer after sclerotherapy and its correlation with treatment outcome and complications. Our study aims to investigate changes in D-dimer in children with VMs undergoing alcohol sclerotherapy. METHODS: A prospective cohort study from 2014 to 2016, which included children (<18years) with VM undergoing alcohol sclerotherapy, was completed...
November 14, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29204841/stereotactic-radiosurgery-for-central-nervous-system-hemangioblastoma-systematic-review-and-meta-analysis
#5
REVIEW
James Pan, Rashad Jabarkheel, Yuhao Huang, Allen Ho, Steven D Chang
Hemangioblastomas are rare, benign, vascular tumors of the central nervous system (CNS), often associated with von-hippel lindau (VHL) disease. Current therapeutic options include microsurgical resection or stereotactic radiosurgery (SRS). With no randomized controlled studies and minimal data beyond single-institution reviews, the optimal management approach for patients with CNS hemangioblastomas is unclear. We completed a Pubmed/SCOPUS literature search from January 1990 to January 2017 for eligible studies on SRS for CNS hemangioblastomas...
December 4, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29196857/pulmonary-subsolid-nodules-value-of-semi-automatic-measurement-in-diagnostic-accuracy-diagnostic-reproducibility-and-nodule-classification-agreement
#6
Hyungjin Kim, Chang Min Park, Eui Jin Hwang, Su Yeon Ahn, Jin Mo Goo
OBJECTIVES: We hypothesized that semi-automatic diameter measurements would improve the accuracy and reproducibility in discriminating preinvasive lesions and minimally invasive adenocarcinomas from invasive pulmonary adenocarcinomas appearing as subsolid nodules (SSNs) and increase the reproducibility in classifying SSNs. METHODS: Two readers independently performed semi-automatic and manual measurements of the diameters of 102 SSNs and their solid portions. Diagnostic performance in predicting invasive adenocarcinoma based on diameters was tested using logistic regression analysis with subsequent receiver operating characteristic curves...
December 1, 2017: European Radiology
https://www.readbyqxmd.com/read/29196091/minimally-invasive-percutaneous-transluminal-renal-artery-stenting
#7
Ken Kongoji, Takanobu Mitarai, Mizuho Kasahara, Hiroshi Yamazaki, Yuki Ishibashi, Kohei Koyama, Kihei Yoneyama, Yasuhiro Tanabe, Yoshihiro J Akashi, Hideaki Yoshino
BACKGROUND: Minimally invasive percutaneous transluminal renal artery stenting (MIPTRS) is a method that prevents complications to the greatest extent possible. The present study aimed to investigate the safety and efficacy of MIPTRS performed in cases of renal artery stenosis with an estimated glomerular filtration rate (eGFR)≤45mL/min. METHODS: Cases of patients who underwent MIPTRS at our hospital between December 2010 and June 2015 in whom eGFR was ≤45mL/min were retrospectively analysed...
November 21, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29188434/photothrombotic-stroke-as-a-model-of-ischemic-stroke
#8
REVIEW
Anatoly B Uzdensky
The search of effective anti-stroke neuroprotectors requires various stroke models adequate for different aspects of the ischemic processes. The photothrombotic stroke model is particularly suitable for the study of cellular and molecular mechanisms underlying neurodegeneration, neuroprotection, and neuroregeneration. It is a model of occlusion of small cerebral vessels, which provides detailed study of molecular mechanisms of ischemic cell death and useful for search of potential anti-stroke agents. Its advantages include well-defined location and size of ischemic lesion that are determined by the aiming of the laser beam at the predetermined brain region; easy impact dosing by changing light intensity and duration; low invasiveness and minimal surgical intervention without craniotomy and mechanical manipulations with blood vessel, which carry the risk of brain trauma; low animal mortality and prolonged sensorimotor impairment that provide long-term study of stroke consequences including behavior impairment and recovery; independence on genetic variations of blood pressure and vascular architecture; and high reproducibility...
November 29, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29173114/a-diagnostic-approach-for-rodent-progressive-cardiomyopathy-and-like-lesions-in-toxicology-studies-up-to-28-days-in-the-sprague-dawley-rat-part-1-of-2
#9
James R Hailey, Beverly E Maleeff, Heath C Thomas, Gail Pearse, Jan C Klapwijk, Patrizia G Cristofori, Brian Berridge, Carie L Kimbrough, George A Parker, Daniel Morton, Susan Elmore, Jerry F Hardisty, Noel O Dybdal, David A Rehagen, James D Fikes, Martin Lamb, Kathleen Biddle, Bernard S Buetow, Vinicius Carreira, Abraham Nyska, Niraj K Tripathi, Heather C Workman, Jean-Guy Bienvenu, Ingrid Brees, James R Turk, Rick R Adler
Spontaneous rodent progressive cardiomyopathy (PCM) in the Sprague Dawley rat may confound identification and/or interpretation of potential test article (TA)-related cardiotoxicity. Pathologists apply diagnostic term(s) and thresholds for diagnosing and assigning severity grades for PCM and/or PCM-like (PCM/like) lesions consistently within a study, which is necessary to identify and interpret TA-related findings. Due to differences in training and/or experiences, diagnostic terms and thresholds may vary between pathologists...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/29168554/relation-between-denaturation-time-measured-by-optical-coherence-reflectometry-and-thermal-lesion-depth-during-radiofrequency-cardiac-ablation-feasibility-numerical-study
#10
Ana González-Suárez, David Herranz, Enrique Berjano, Jose L Rubio-Guivernau, Eduardo Margallo-Balbás
BACKGROUND/OBJECTIVE: Radiofrequency (RF) catheter ablation is a minimally invasive medical procedure used to thermally destroy the focus of cardiac arrhythmias. Novel optical techniques are now being integrated into RF catheters in order to detect the changes in tissue properties. Loss of birefringence due to fiber denaturation at around 70°C is related to changes in accumulated phase retardation and can be measured by polarization-sensitive optical coherence reflectometry (PS-OCR)...
November 23, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29167166/blood-borne-interleukin-1%C3%AE-acts-upon-the-subfornical-organ-to-upregulate-the-sympathoexcitatory-milieu-of-the-hypothalamic-paraventricular-nucleus
#11
Shun-Guang Wei, Yang Yu, Robert B Felder
We previously reported that microinjection of the pro-inflammatory cytokine interleukin-1 beta (IL-1β) into the subfornical organ (SFO) elicits a pressor response accompanied by increases in inflammation and renin-angiotensin system (RAS) activity in the SFO and in the hypothalamic paraventricular nucleus (PVN). The present study sought to determine whether blood-borne IL-1β induces similar neurochemical changes in the SFO and PVN, and, if so, whether increased inflammation and RAS activity at the SFO level orchestrate the sympathoexcitatory response to circulating IL-1β...
November 22, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29165656/limited-midline-myelotomy-for-intractable-visceral-pain-surgical-techniques-and-outcomes
#12
Aditya Vedantam, Dhanalakshmi Koyyalagunta, Brian Mendoza Bruel, Patrick M Dougherty, Ashwin Viswanathan
BACKGROUND: Limited midline myelotomy targets the midline nociceptive pathway for intractable visceral pain. Multiple techniques are available for limited midline myelotomy; however, outcome data for each technique are sparse. OBJECTIVE: To review our experience with open and percutaneous approaches for limited midline myelotomy for intractable visceral pain. METHODS: Patients who underwent limited midline myelotomy for intractable visceral pain were reviewed...
November 18, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29165417/-pterygium-etiology-pathogenesis-treatment
#13
S A Malozhen, S V Trufanov, D A Krakhmaleva
Pterygium is a degenerative condition characterized by fibrovascular outgrowth of conjunctiva over the cornea. Many theories exist that try to explain its pathogenesis. The current belief is that this disease is multifactorial with ultraviolet radiation being the most important trigger. Attention is also paid to such factors as tear film changes, cytokines and growth factors disbalance, immunologic disturbances, genetic mutations, and viral infections. Modern classifications consider the rate of fibrovascular growth, its progressive potential, and histological features...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29152699/comparative-analysis-of-the-protective-effects-of-curcumin-and-n-acetyl-cysteine-against-paracetamol-induced-hepatic-renal-and-testicular-toxicity-in-wistar-rats
#14
Zeynab Kh El-Maddawy, Yasser S El-Sayed
This study aimed to investigate the possible protective role of curcumin (CUR) vs. N-acetyl cysteine (NAC) against paracetamol (PCM)-induced oxidative damage and impairment of liver, kidney, and testicular functions, as well as hematotoxicity, in albino rats. A large single dose of PCM induced lipid peroxidation along with a significant decline in glutathione content and catalase activity in the liver, kidneys, and testicles. The apparent oxidative damage was associated with evident hepatic, renal, and testicular dysfunction, which was confirmed in histopathological lesions, and increased serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activities...
November 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29149150/the-hopeless-case-palliative-cryoablation-and-cementoplasty-procedures-for-palliation-of-large-pelvic-bone-metastases
#15
Tyler M Coupal, Kevin Pennycooke, Paul I Mallinson, Hugue A Ouellette, Paul W Clarkson, Pippa Hawley, Peter L Munk
BACKGROUND: Metastases to the bone are common in cancer patients, and it has been estimated that up to 50% of patients with pelvic bone metastases will not achieve adequate pain control with medications alone. This has led to a paradigm shift over recent years towards the use and development of minimally invasive image-guided treatment options for palliation of bony metastases. Despite these developments, large metastatic lesions are still often considered to be "hopeless cases" that would garner little to no benefit from image-guided intervention...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29148927/flat-serrated-polyps-at-ct-colonography-relevance-appearance-and-optimizing-interpretation
#16
David H Kim, Meghan G Lubner, Ashley R Cahoon, B Dustin Pooler, Perry J Pickhardt
Serrated polyps are a recently recognized family of colonic polyps with subgroups that harbor future malignant potential. In the past, the significance of these lesions to the colorectal cancer carcinogenesis pathway was not recognized nor well understood. It is now known that serrated polyps account for approximately one-fourth of all sporadic colorectal cancers. The sessile serrated polyp (SSP) (also known as a sessile serrated adenoma [SSA]) is the main lesion of interest given its prevalence and subtle presentation...
November 17, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29131800/qualitative-and-quantitative-evaluation-of-dynamic-changes-in-non-culprit-coronary-atherosclerotic-lesion-morphology-a-longitudinal-oct-study
#17
Bu-Chun Zhang, Antonios Karanasos, Muthukaruppan Gnanadesigan, Johannes N van der Sijde, Nienke van Ditzhuijzen, Karen T Witberg, Jurgen Ligthart, Roberto Diletti, Robert-Jan van Geuns, Jouke Dijkstra, Felix Zijlstra, Gijs van Soest, Evelyn Regar
AIMS: There is limited in vivo evidence regarding the temporal evolution of non-culprit coronary plaque morphology. We evaluated changes in non-culprit plaque morphology over time by optical coherence tomography (OCT). METHODS AND RESULTS:  72 patients with 257 non-culprit segments with serial OCT studies were analyzed. Non-culprit 5mm-long coronary segments from the same imaged region were matched between baseline and follow-up. OCT plaque characterization including automated attenuation analysis was performed and changes over a median follow-up of 6...
November 14, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29122731/post-surgical-cavity-evolution-after-brain-metastases-resection-how-soon-should-postoperative-radiosurgery-follow
#18
Rajal A Patel, Derrick Lock, Irene B Helenowski, James P Chandler, Sean Sachdev, Matthew C Tate, Tim J Kruser
BACKGROUND: Postoperative stereotactic radiosurgery (SRS) to the cavity following resection of brain metastases (BM) improves local control (LC). We hypothesized that significant cavity constriction would take place from the immediate postoperative period to the time of SRS and aimed to elucidate optimal treatment timing. METHODS: We retrospectively reviewed seventy-nine consecutive patients with eighty-five resection cavities treated with SRS following gross total resection of a BM...
November 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29105512/changes-in-the-metabolome-and-microrna-levels-in-biological-fluids-might-represent-biomarkers-of-neurotoxicity-a-trimethyltin-study
#19
Syed Z Imam, Zhen He, Elvis Cuevas, Hector Rosas-Hernandez, Susan M Lantz, Sumit Sarkar, James Raymick, Bonnie Robinson, Joseph P Hanig, David Herr, Denise MacMillan, Aaron Smith, Serguei Liachenko, Sherry Ferguson, James O'Callaghan, Diane Miller, Christopher Somps, Ingrid D Pardo, William Slikker, Jennifer B Pierson, Ruth Roberts, Binsheng Gong, Weida Tong, Michael Aschner, Mary J Kallman, David Calligaro, Merle G Paule
Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid have great potential due to the relative ease of sampling but at present, data on their expression and translation are lacking or inconsistent. In this pilot study using a trimethyl tin rat model of central nervous system toxicity, we have applied state-of-the-art assessment techniques to identify potential individual biomarkers and patterns of biomarkers in serum, plasma, urine or cerebral spinal fluid that may be indicative of nerve cell damage and degeneration...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29103840/the-influence-of-full-thickness-chondral-defects-on-outcomes-following-meniscal-allograft-transplantation-a-comparative-study
#20
Bryan M Saltzman, Maximilian A Meyer, Timothy S Leroux, Matthew E Gilelis, Margot Debot, Adam B Yanke, Brian J Cole
PURPOSE: To compare a series of patients who underwent meniscus allograft transplantation (MAT) with full-thickness chondral defects (FTD) with those with no chondral defect (ND) with regard to the following: change in patient-reported outcomes (PROs) from baseline to 2-year follow-up and baseline to the final follow-up (including comparisons to minimal clinically important differences), complications and complication rates, reoperations and reoperation rates/timing, and failures and time to failure (revision MAT or conversion to total knee arthroplasty)...
November 2, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
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