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minimal change lesion

Sivashanmugam Dhandapani, Madhivanan Karthigeyan
BACKGROUND: Endoscopy is increasingly being used for minimal invasiveness and panoramic visualization, with unclear efficacy and safety among spinal intradural lesions. OBJECTIVE: To compare micro-endoscopic and pure-endoscopic surgery for spinal intradural lesions. METHODS: Spinal intradural lesions operated by us using endoscopic/access ports were categorized 'micro-endoscopic' (predominant microscope use), or 'pure-endoscopic' (standalone endoscopy) surgery, and studied with respect to clinico-radiological features, techniques, peri-operative course, histopathology, clinical and radiological outcome at minimum of 3 months...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
Yiu Tung Anthony Wong, Do-Yoon Kang, Jin Bae Lee, Seung-Woon Rha, Young Joon Hong, Eun-Seok Shin, Sung-Ho Her, Chang Wook Nam, Woo-Young Chung, Moo Hyun Kim, Cheol Hyun Lee, Pil Hyung Lee, Jung-Min Ahn, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Duk-Woo Park, Seung-Jung Park
BACKGROUND: This study sought to evaluate the optimal treatment for in-stent restenosis (ISR) of drug-eluting stents (DESs). METHODS: This is a prospective, multicenter, open-label, randomized study comparing the use of drug-eluting balloon (DEB) versus second-generation everolimus-eluting stent for the treatment of DES ISR. The primary end point was in-segment late loss at 9-month routine angiographic follow-up. RESULTS: A total of 172 patients were enrolled, and 74 (43...
March 2018: American Heart Journal
Hadeer O Abou-Hany, Hoda Atef, Eman Said, Hassan Elkashef, Hatem A Salem
Diabetic Nephropathy (DN) is one of the main complications associated with diabetes mellitus. Persistently elevated blood glucose level drives histopathological changes in renal tissues that hinder normal kidney functions. In the current study, crocin; the main bioactive constituent of Crocus sativus was investigated as a reno-protective agent against DN by virtue of its numerous pharmacological activities. Diabetes was induced in male Sprague-Dawely rats through intravenous injection of streptozocin (STZ) (50 mg/kg), DN was confirmed eight weeks post diabetes induction...
February 2, 2018: Chemico-biological Interactions
M G Maglione, A Guida, E Pavone, F Longo, C Aversa, S Villano, F Ionna
Tumours arising from the parapharyngeal space (PPS) represent less than 1% of all head and neck tumours. Salivary gland tumours account for 40-50% of PPS lesions and are located in the pre-styloid parapharyngeal space. Pleomorphic adenomas represent 80-90% of salivary tumours in the PPS. Recently, transoral robotic surgery (TORS) has become common in head and neck surgery as a minimally invasive procedure. Four cases of benign PPS tumour treated with TORS are presented here. Preoperative diagnosis was conducted by fine needle aspiration biopsy and magnetic resonance imaging, and the results were used to plan the correct surgical approach...
January 31, 2018: International Journal of Oral and Maxillofacial Surgery
Joana B Neves, John Withington, Sarah Fowler, Prasad Patki, Ravi Barod, Faiz Mumtaz, Tim O'Brien, Michael Aitchison, Axel Bex, Maxine Gb Tran
OBJECTIVES: To report on the contemporary UK experience of surgical management of renal oncocytomas. SUBJECTS AND METHODS: Descriptive analysis of practice and postoperative outcomes of cases with a final histological diagnosis of oncocytoma included in The British Association of Urological Surgeons (BAUS) nephrectomy registry from 01/01/2013 to 31/12/2016. Short term outcomes were assessed over a follow-up of 30 days. RESULTS: Over 4 years, 32130 renal surgical cases were recorded in the UK, of which 1202 were oncocytomas (3...
February 3, 2018: BJU International
Masakazu Okawa, Toshio Higashi, Kenji Fukuda, Toshiyasu Ogata, Tsutomu Yoshioka, Tooru Inoue
BACKGROUND: The aim of this study was to evaluate the safety and feasibility of carotid artery stenting (CAS) employing dual-ultrasound technique and administering a minimal contrast agent in patients with renal insufficiency. METHODS: Between September 2009 and July 2013, 63 consecutive patients underwent CAS at our institution: dual-echo carotid artery stenting (DECAS) in 7 patients with renal insufficiency and standard carotid artery stenting (STCAS) in the remaining 56 patients...
January 25, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Emily M Wong, William F Walby, Dennis W Wilson, Fern Tablin, Edward S Schelegle
BACKGROUND: Particulate matter (PM) and ozone (O3) are dominant air pollutants that contribute to development and exacerbation of multiple cardiopulmonary diseases. Mature adults with cardiovascular disease (CVD) are particularly susceptible to air pollution-related cardiopulmonary morbidities and mortalities. OBJECTIVES: The aim was to investigate the biologic potency of ultrafine particulate matter (UFPM) combined with O3 in the lungs of mature adult normotensive and spontaneously hypertensive Wistar-Kyoto rats...
January 31, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
Hung-Cheng Kan, See-Tong Pang, Chun-Te Wu, Ying-Hsu Chang, Chung-Yi Liu, Cheng-Keng Chuang, Po-Hung Lin
RATIONALE: Laparoscopic adrenalectomy is currently the standard of care for adrenal lesion. Minimal invasive laparoscopic surgery such as laparoendoscopic single site surgery (LESS) and natural orifice transluminal endoscopic surgery (NOTES) have been developed to improve cosmetic outcomes and reduce postoperative pain. However, there are still some problems related to instruments and port limitation during LESS surgery. Robot-assisted laparoscopic surgery may help to overcome these problems, and port platforms selection is an important issue...
December 2017: Medicine (Baltimore)
Ho Kyoung Hwang, Jiae Park, Sung Hoon Choi, Chang Moo Kang, Woo Jung Lee
The purpose of this study was to evaluate the time-dependent probability and risk factors of pancreatogenic diabetes mellitus (PDM) in patients who underwent minimally invasive subtotal distal pancreatectomy.Changes in glucose metabolic consequence of 34 patients (laparoscopic: 31, robotic: 3) who underwent surgery from December 2005 to December 2014 were estimated by assessing impaired fasting glucose, PDM, and PDM-free time analysis.A total of 22 patients showed glucose intolerance, including 13 (38.2%) with impaired fasting glucose and 9 (26...
December 2017: Medicine (Baltimore)
Jeffrey R Hebert, John R Corboy, Timothy Vollmer, Jeri E Forster, Margaret Schenkman
OBJECTIVE: To determine whether a multifaceted vestibular-related rehabilitation program (Balance and Eye-Movement Exercises for Persons with Multiple Sclerosis; BEEMS) improves balance in persons with MS and whether there are differences in outcomes based on brainstem/cerebellar lesion involvement. METHODS: A 2-arm, examiner-blinded, stratified (involvement vs no involvement of brainstem/cerebellar structures), randomized controlled trial was implemented. Eighty-eight participants were allocated to BEEMS or no treatment control...
January 31, 2018: Neurology
Young Hun Kim, Mi Seong Jo, Jin Kwon Kim, Jae Hoon Shin, Jin Ee Baek, Hye Seon Park, Hyo Jin An, Jong Seong Lee, Boo Wook Kim, Hoi Pin Kim, Kang Ho Ahn, KiSoo Jeon, Seung Min Oh, Ji Hyun Lee, Tomomi Workman, Elaine M Faustman, Il Je Yu
Graphene oxides possess unique physicochemical properties with important potential applications in electronics, pharmaceuticals, and medicine. However, the toxicity following inhalation exposure to graphene oxide has not yet been clarified. Therefore, this study conducted a short-term graphene oxide inhalation toxicity analysis using a nose-only inhalation exposure system and male Sprague-Dawley rats. A total of four groups (15 rats per group) were exposed: (1) control (fresh air), (2) low concentration (0...
February 1, 2018: Nanotoxicology
Soo-Yeon Kim, Nariya Cho, Sung Ui Shin, Han-Byoel Lee, Wonshik Han, In Ae Park, Bo Ra Kwon, Soo Yeon Kim, Su Hyun Lee, Jung Min Chang, Woo Kyung Moon
OBJECTIVES: To retrospectively investigate whether the lesion-to-background parenchymal signal enhancement ratio (SER) on breast MRI can distinguish pathological complete response (pCR) from minimal residual cancer following neoadjuvant chemotherapy (NAT), and compare its performance with the conventional criterion. METHODS: 216 breast cancer patients who had undergone NAT and MRI and achieved pCR or minimal residual cancer on surgical histopathology were included...
January 29, 2018: European Radiology
Hsin-Fu Lee, Shing-Hsien Chou, Ying-Chang Tung, Chia-Pin Lin, Yu-Shien Ko, Chi-Jen Chang
Background: This study aims to analyze the lesion characteristics of bifurcations that required reverse wire technique and the efficacy and safety of this technique in approaching branches with a highly angulated take-off. Methods: We enrolled patients in whom reverse wire technique was used after failed conventional antegrade wiring with the support of a Crusade catheter. The study endpoints were the technical success defined as succeeding in sending the reversely bent wire to the targeted branches without complications and the procedural success defined as succeeding in revascularization of the bifurcation lesions without complications...
January 2018: Acta Cardiologica Sinica
Kui Xu, Qin Zhao, Xintian Wen, Rui Wu, Yiping Wen, Xiaobo Huang, Yong Huang, Qigui Yan, Xinfeng Han, Xiaoping Ma, Yung-Fu Chang, Sanjie Cao
Actinobacillus pleuropneumoniae (APP) causes serious economic losses in the swine industry, and is the etiologic agent of porcine pleuropneumonia. In this study we have engineered a trivalent Apx fusion protein enclosed in outer membrane vesicles (Apxr-OMV) and studied its immunoprotective efficacy against APP serotypes 1 and 7 challenge in mice. The results showed that the IgG levels in the Apxr-OMVs immune group were significantly higher than those of the negative control (P < 0.05). Up-regulation of both Th1 (IFN-γ, IL-2) and Th2 (IL-4) cytokines were detected in splenocytes of Apxr-OMVs immune group...
2018: PloS One
Chao Wu, Juan Huang, Wen-Bin Xu, Yong-Jing Guan, Hua-Wei Ling, Jian-Qing Mi, Hua Yan
RATIONALE AND OBJECTIVES: This study aimed to measure apparent diffusion coefficient (ADC) in Chinese patients with newly diagnosed multiple myeloma by whole-body diffusion-weighted magnetic resonance imaging (WB-DWI MRI) and assess the diagnostic accuracy of ADC in the discrimination of deep response to induction chemotherapy. MATERIALS AND METHODS: Seventeen patients underwent WB-DWI MRI before and after induction chemotherapy (week 20). DWI images and ADC maps were produced and 89 regions of interest were chosen...
January 16, 2018: Academic Radiology
Anna Carbone, Isabella Sperduti, Paola DE Simone, Paolo Piemonte, Angela Ferrari, Pierluigi Buccini, Vitaliano Silipo, Alessandra Iorio, Pasquale Frascione, Laura Eibenschutz
BACKGROUND: Actinic keratosis (AK) is a photo-induced skin lesion. It has been considered by several authors as in situ squamous cell carcinoma (SCC), that can evolve to invasive SCC (iSCC). Given the malignant potential and because it's impossible predict which AK will evolve in iSCC, it's necessary to treat each lesion. Multiple therapeutic approaches have been described to treat AKs. In addition to the topical drugs, photodynamic therapy (PDT) has become an established therapeutic modality for grade I and II of AKs of face and scalp...
January 24, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Dong Hyun Yang, Soo-Jin Kang, Hyun Jung Koo, Jihoon Kweon, Joon-Won Kang, Tae-Hwan Lim, Joonho Jung, Namkug Kim, June-Goo Lee, Seungbong Han, Jung-Min Ahn, Duk-Woo Park, Seung-Whan Lee, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park, Gary S Mintz, Young-Hak Kim
OBJECTIVES: This study examined the incremental value of subtended myocardial mass (V sub ) as assessed by coronary computed tomography angiography (CTA) for identifying lesion-specific ischemia verified by invasive fractional flow reserve (FFR) in quantitative coronary CTA. BACKGROUND: FFR is determined not only by coronary stenosis severity, but also by V sub . One-step evaluation of combined V sub and coronary lesion morphology may improve the accuracy of coronary CTA for identifying ischemia-producing lesions...
January 12, 2018: JACC. Cardiovascular Imaging
Paula Alcaide-Leon, Kateryna Cybulsky, Stephanie Sankar, Courtney Casserly, General Leung, Marika Hohol, Daniel Selchen, Xavier Montalban, Aditya Bharatha, Jiwon Oh
Objectives: To assess whether quantitative spinal cord MRI (SC-MRI) measures, including atrophy, and diffusion tensor imaging (DTI) and magnetization transfer imaging metrics were different in radiologically isolated syndrome (RIS) vs healthy controls (HCs). Methods: Twenty-four participants with RIS and 14 HCs underwent cervical SC-MRI on a 3T magnet. Manually segmented regions of interest circumscribing the spinal cord cross-sectional area (SC-CSA) between C3 and C4 were used to extract SC-CSA, fractional anisotropy, mean, perpendicular, and parallel diffusivity (MD, λ⊥, and λ||) and magnetization transfer ratio (MTR)...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
For Yue Tso, Andrew V Kossenkov, Salum J Lidenge, Owen Ngalamika, John R Ngowi, Julius Mwaiselage, Jayamanna Wickramasinghe, Eun Hee Kwon, John T West, Paul M Lieberman, Charles Wood
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma (KS). It is endemic in a number of sub-Saharan African countries with infection rate of >50%. The high prevalence of HIV-1 coupled with late presentation of advanced cancer staging make KS the leading cancer in the region with poor prognosis and high mortality. Disease markers and cellular functions associated with KS tumorigenesis remain ill-defined. Several studies have attempted to investigate changes of the gene profile with in vitro infection of monoculture models, which are not likely to reflect the cellular complexity of the in vivo lesion environment...
January 19, 2018: PLoS Pathogens
Jorge Chahla, Nicholas I Kennedy, Andrew G Geeslin, Gilbert Moatshe, Mark E Cinque, Nicholas N DePhillipo, Robert F LaPrade
Meniscal injuries and meniscal loss are associated with changes in knee kinematics and loading, ultimately leading to poor functional outcomes and increased risk of progression to osteoarthritis. Biomechanical studies have shown restored knee function, and clinical studies have reported improved outcomes and decreased risk of osteoarthritis after meniscal repair. This has led orthopaedic surgeons to try and save the meniscus by repair whenever possible, as shown by increasing incidence of meniscal repair surgeries...
December 2017: Arthroscopy Techniques
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