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S100B , Delirium

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https://www.readbyqxmd.com/read/27641367/unraveling-the-relationship-between-delirium-brain-damage-and-subsequent-cognitive-decline-in-a-cohort-of-individuals-undergoing-surgery-for-hip-fracture
#1
Sara J E Beishuizen, Rikie M Scholtens, Barbara C van Munster, Sophia E de Rooij
OBJECTIVES: To assess the association between serum S100B levels (a marker of brain damage), delirium, and subsequent cognitive decline. DESIGN: Substudy of a multicenter randomized controlled trial. SETTING: Surgical, orthopedic, and trauma surgery wards of two teaching hospitals. PARTICIPANTS: Individuals aged 65 and older (range 65-102) admitted for hip fracture surgery (N = 385). MEASUREMENTS: During hospitalization, presence of delirium was assessed daily...
September 19, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27436624/prognostic-value-of-acute-delirium-recovery-in-older-adults
#2
Carlos Jorge-Ripper, María-Remedios Alemán, Rosa Ros, Selena Aguilera, Emilio González-Reimers, Elisa Espelosín, Francisco Santolaria
AIM: To analyze the prognostic impact of short-term changes in the intensity of delirium in association or not with sepsis. We also aimed to analyze if s100B, a serum protein derived from astrocytes related to cerebral damage, could be a marker of delirium or sepsis. METHODS: We included 47 patients with acute delirium and sepsis, 36 with delirium and no evidence of infection, and 36 patients with sepsis without delirium. The diagnosis of delirium was established by the Confusion Assessment Method...
July 19, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27088157/endothelial-activation-and-blood-brain-barrier-injury-as-risk-factors-for-delirium-in-critically-ill-patients
#3
Christopher G Hughes, Pratik P Pandharipande, Jennifer L Thompson, Rameela Chandrasekhar, Lorraine B Ware, E Wesley Ely, Timothy D Girard
OBJECTIVES: During critical illness, impaired endothelial vascular reactivity predicts prolonged acute brain dysfunction, but relationships between endothelial activation, blood-brain barrier/neurological injury, and acute brain dysfunction, including delirium, remain unexamined. We tested the hypothesis that elevated plasma markers of endothelial activation and blood-brain barrier/neurological injury are associated with delirium duration during critical illness. DESIGN: Prospective cohort study...
September 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/24883321/cortisol-is-an-associated-risk-factor-of-brain-dysfunction-in-patients-with-severe-sepsis-and-septic-shock
#4
Duc Nam Nguyen, Luc Huyghens, Haibo Zhang, Johan Schiettecatte, Johan Smitz, Jean-Louis Vincent
OBJECTIVES: To investigate cortisol levels in brain dysfunction in patients with severe sepsis and septic shock. METHODS: In 128 septic and sedated patients, we studied brain dysfunction including delirium and coma by the evaluation of Richmond Agitation Sedation Scale (RASS), the Confusion Method Assessment in the ICU (CAM-ICU) after sedation withdrawal and the measurement of serum S100B biomarker of brain injury. Serum cortisol and S100B were measured within 12 hours after ICU admission and daily over the next four days...
2014: BioMed Research International
https://www.readbyqxmd.com/read/23860667/serum-s100b-protein-could-help-to-detect-cerebral-complications-associated-with-extracorporeal-membrane-oxygenation-ecmo
#5
Duc Nam Nguyen, Luc Huyghens, Francis Wellens, Johan Schiettecatte, Johan Smitz, Jean-Louis Vincent
BACKGROUND: To investigate if serum S100B protein levels could early detect cerebral complications under treatment extracorporeal membrane oxygenation (ECMO). METHODS: Serum S100B levels were measured over 5 days in 32 patients with cardiogenic and septic shock, including 15 patients who treated by ECMO and 17 who did not. Cerebral complications included hemorrhage, stroke, encephalopathy with myoclonus, and brain death. Delirium was identified by the positive Confusion Assessment Method in the ICU...
June 2014: Neurocritical Care
https://www.readbyqxmd.com/read/23602305/delirium-and-cerebrospinal-fluid-s100b-in-hip-fracture-patients-a-preliminary-study
#6
Roanna J Hall, Karen J Ferguson, Mary Andrews, Alison J E Green, Tim O White, Ian R Armstrong, Alasdair M J MacLullich
OBJECTIVES: Delirium is associated with an increased risk of long-term cognitive decline, suggesting the possibility of concurrent central nervous system (CNS) injury. S100B is a putative biomarker of CNS injury and elevated serum levels in delirium have been reported. Here we hypothesize that delirium is associated with raised concentrations of cerebrospinal fluid (CSF) S100B. METHODS: Forty-five patients with hip fracture aged over 60 and awaiting surgery under spinal anesthesia were assessed for delirium pre- and post-operatively...
December 2013: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/23473361/the-impact-of-s100b-and-persistent-high-levels-of-neuron-specific-enolase-on-cognitive-performance-in-elderly-patients-after-cardiopulmonary-bypass
#7
Andreas Baranyi, Hans-Bernd Rothenhäusler
PRIMARY OBJECTIVES: The primary aim was to investigate the impact of neuron-specific enolase (NSE) and S100 calcium-binding protein B (S100b) on cognitive functioning after cardiopulmonary bypass (CPB). RESEARCH DESIGN: Prospective exploratory study. SETTING: Psychiatric Consultation-Liaison Service, Ludwig-Maximilians-University Medical School, Munich, Germany. PARTICIPANTS: Thirty-four patients who underwent elective CPB...
2013: Brain Injury: [BI]
https://www.readbyqxmd.com/read/20580479/cortisol-interleukins-and-s100b-in-delirium-in-the-elderly
#8
Barbara C van Munster, Peter H Bisschop, Aeilko H Zwinderman, Johanna C Korevaar, Erik Endert, W Joost Wiersinga, Hannah E van Oosten, J Carel Goslings, Sophia E J A de Rooij
In independent studies delirium was associated with higher levels of cortisol, interleukin(IL)s, and S100B. The aim of this study was to simultaneously compare cortisol, IL-6, IL-8, and S100B levels in patients aged 65years and older admitted for hip fracture surgery with and without delirium. Cortisol, IL-6, IL-8, and S100B were assayed in repeated blood samples. 120 patients (mean age 84years, 62 patients with delirium) were included. Highest levels of IL-8 (27.1, 95% Confidence Interval (CI): 13.6-53.1pg/ml) and cortisol (666, 95% CI: 475-859nmol/L) were before delirium, but of IL-6 (84...
October 2010: Brain and Cognition
https://www.readbyqxmd.com/read/20530241/cerebrospinal-fluid-in-long-lasting-delirium-compared-with-alzheimer-s-dementia
#9
COMPARATIVE STUDY
Gideon A Caplan, Tasha Kvelde, Christina Lai, Swee L Yap, Cheryl Lin, Mark A Hill
BACKGROUND: Delirium is a common syndrome affecting older people in hospital, whose pathophysiology is poorly understood, but sequelae of increased cognitive and functional impairment suggest neuronal loss. METHODS: Cohort study comparing cerebrospinal fluid, blood, and clinical markers of delirium and neuronal cell death in 20 older hospitalized patients with delirium and 20 outpatients with Alzheimer's dementia. RESULTS: Compared with participants with dementia, patients with delirium demonstrated higher CSF lactate (1...
October 2010: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/19809934/septic-encephalopathy-relationship-to-serum-and-cerebrospinal-fluid-levels-of-adhesion-molecules-lipid-peroxides-and-s-100b-protein
#10
S A Hamed, E A Hamed, M M Abdella
Severe septic illness is often associated with cerebral manifestations such was disturbed consciousness and delirium. Little was known about its effect on the CNS. This is the first study in children that has assessed the direct mediators of brain inflammation and injury with sepsis. The serum and CSF concentrations of soluble intracellular adhesion molecule-1 (sICAM-1) (marker of endothelium-leukocyte interaction), nitric oxide (NO) and lipid peroxide (LPO) (markers for lipid peroxidation) and S-100B protein (marker of astrocytes activation and injury), were measured in 40 children with sepsis of whom 40% had moderate to severe septic encephalopathy...
April 2009: Neuropediatrics
https://www.readbyqxmd.com/read/19575407/serum-s100b-in-elderly-patients-with-and-without-delirium
#11
Barbara C van Munster, Johanna C Korevaar, Catharina M Korse, Johannes M Bonfrer, Aeilko H Zwinderman, Sophia E de Rooij
OBJECTIVE: Elevation of S100B has been shown after various neurologic diseases with cognitive dysfunction. The aim of this study was to compare the serum level of S100B of patients with and without delirium and investigate the possible associations with different subtypes of delirium. METHODS: Acutely admitted medical patients aged 65 years or more were included from 2005 through 2008. Delirium was diagnosed by Confusion Assessment Method, delirium subtype by Delirium Symptom Interview and preexistent global cognitive function by the 'Informant Questionnaire on Cognitive Decline-short form'...
March 2010: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/19473521/markers-of-cerebral-damage-during-delirium-in-elderly-patients-with-hip-fracture
#12
Barbara C van Munster, Catharina M Korse, Sophia E de Rooij, Johannes M Bonfrer, Aeilko H Zwinderman, Johanna C Korevaar
BACKGROUND: S100B protein and Neuron Specific Enolase (NSE) can increase due to brain cell damage and/or increased permeability of the blood-brain-barrier. Elevation of these proteins has been shown after various neurological diseases with cognitive dysfunction. Delirium is characterized by temporal cognitive deficits and is an important risk factor for dementia. The aim of this study was to compare the level of S100B and NSE of patients before, during and after delirium with patients without delirium and investigate the possible associations with different subtypes of delirium...
2009: BMC Neurology
https://www.readbyqxmd.com/read/16627793/nmda-receptor-antibodies-predict-adverse-neurological-outcome-after-cardiac-surgery-in-high-risk-patients
#13
Paula M Bokesch, Galina A Izykenova, Joseph B Justice, Kirk A Easley, Svetlana A Dambinova
BACKGROUND AND PURPOSE: The goal of this study was to compare the predictive ability of S100B, N-methyl-D-aspartate (NMDA) receptor antibodies (NR2Ab) and C-reactive protein (CRP) for neurological deficits after cardiac surgery with cardiopulmonary bypass (CPB). METHODS: We investigated 557 high-risk adult patients who underwent coronary artery or valve replacement surgery using CPB as a substudy of a prospective, blinded, multicenter clinical trial. Serum concentrations of S100B (n=513 patients), NR2Ab (n=398) and CRP (n=510) were measured preoperatively, 24 and 48 hours after CPB...
June 2006: Stroke; a Journal of Cerebral Circulation
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