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https://www.readbyqxmd.com/read/29625618/exposure-to-radial-extracorporeal-shock-waves-modulates-viability-and-gene-expression-of-human-skeletal-muscle-cells-a-controlled-in-vitro-study
#1
Stefan G Mattyasovszky, Eva K Langendorf, Ulrike Ritz, Christoph Schmitz, Irene Schmidtmann, Tobias E Nowak, Daniel Wagner, Alexander Hofmann, Pol M Rommens, Philipp Drees
BACKGROUND: Recent clinical and animal studies have shown that extracorporeal shock wave therapy has a promoting influence on the healing process of musculoskeletal disorders. However, the underlying biological effects of extracorporeal shock wave therapy on human skeletal muscle cells have not yet been investigated. METHODS: In this study, we investigated human skeletal muscle cells after exposure to radial extracorporeal shock waves in a standardized in vitro setup...
April 6, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29593445/effect-of-selection-for-eventing-on-the-mstn-gene-in-brazilian-sport-horses
#2
Felipe Gomes Ferreira Padilha, Kênia Balbi El-Jaick, Liane de Castro, Aline Dos Santos Moreira, Ana Maria Reis Ferreira
Polymorphisms in MSTN have previously been associated with equine performance. Therefore, the aim of this study was to identify variants in MSTN intron 1 in 16 Brazilian Sport Horses selected for competition in eventing and their possible effects of selection on performance. Among the nine variants identified, eight had already been reported in previous studies or genomic databases, although they showed differences in frequencies when compared with other horse breeds. Moreover, a new mutation was identified in two horses, both in heterozygous form...
2018: Journal of Equine Science
https://www.readbyqxmd.com/read/29543920/the-relationship-between-ca-repeat-polymorphism-of-the-igf-1-gene-and-the-structure-of-motor-skills-in-young-athletes
#3
Krzysztof Karpowicz, Katarzyna Krych, Małgorzata Karpowicz, Witold Nowak, Piotr Gronek
The map of candidate genes that can potentially affect physical fitness becomes larger every year, and they are associated with such aspects as respiratory and cardiovascular stability; body build and composition - especially muscle mass and strength; carbohydrate and lipid metabolism; response to training; and exercise intolerance.The aim of this study was to analyze the relationship between the CA repeat polymorphism of the P1 promoter of the IGF1 gene and the structure of motor skills in the two groups of Polish young athletes in 2011-2013...
March 15, 2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29534260/two-genetic-variants-associated-with-plantar-fascial-disorders
#4
Stuart K Kim, John P A Ioannidis, Marwa A Ahmed, Andrew L Avins, John P Kleimeyer, Michael Fredericson, Jason L Dragoo
Plantar fascial disorder is comprised of plantar fasciitis and plantar fibromatosis. Plantar fasciitis is the most common cause of heel pain, especially for athletes involved in running and jumping sports. Plantar fibromatosis is a rare fibrous hyperproliferation of the deep connective tissue of the foot. To identify genetic loci associated with plantar fascial disorders, a genome-wide association screen was performed using publically available data from the Research Program in Genes, Environment and Health including 21,624 cases of plantar fascial disorders and 80,879 controls...
March 13, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29515596/genomic-sequencing-of-japanese-plum-prunus-salicina-lindl-mutants-provides-a-new-model-for-rosaceae-fruit-ripening-studies
#5
Angel Fernandez I Marti, Christopher A Saski, George A Manganaris, Ksenija Gasic, Carlos H Crisosto
It has recently been described that the Japanese plum "Santa Rosa" bud sport series contains variations in ripening pattern: climacteric, suppressed-climacteric and non-climacteric types. This provides an interesting model to study the role of ethylene and other key mechanisms governing fruit ripening, softening and senescence. The aim of the current study was to investigate such differences at the genomic level, using this series of plum bud sports, with special reference to genes involved in ethylene biosynthesis, signal transduction, and sugar metabolism...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29491232/molecular-epidemiology-of-trichophyton-tonsurans-the-causative-dermatophyte-of-the-epidemic-of-tinea-gladiatorum-in-japan-between-2011-and-2015
#6
Yuichi Sakata, Tsuyoshi Ushigami, Kazushi Anzawa, Takashi Mochizuki
Trichophyton tonsurans, a major pathogen of tinea capitis and tinea corporis, has been isolated from players of contact sports in Japan. To understand the contemporary epidemic in Japan, the molecular types of 208 strains isolated between 2011 and 2015 were determined. Of these, 142 were isolated from practitioners of judo, 28 from wrestlers, seven from sumo wrestlers, and 31 from individuals with unknown backgrounds. Based on length polymorphisms of the non-transcribed spacer (NTS) region of the ribosomal RNA gene, these 208 strains could be divided into three subtypes, NTS I(204; 98...
February 28, 2018: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29486610/a-multicenter-double-blind-phase-iii-clinical-trial-to-evaluate-the-efficacy-and-safety-of-a-cell-and-gene-therapy-in-knee-osteoarthritis-patients
#7
Myung-Ku Kim, Chul-Won Ha, Yong In, Sung-Do Cho, Eui-Sung Choi, Jeong-Ku Ha, Ju-Hong Lee, Jae-Doo Yoo, Seong-Il Bin, Choong-Hyeok Choi, Hee-Soo Kyung, Myung-Chul Lee
OBJECTIVE: To test the clinical efficacy of TissueGene-C (TG-C), a cell and gene therapeutic for osteoarthritis consisting of non-transformed and transduced chondrocytes (3:1), retrovirally transduced to overexpress TGF-β1. DESIGN: We randomly assigned 163 with knee osteoarthritis to receive intra-articular TG-C or placebo in Kellgren-Lawrence grade 3 patients for clinical trial. Primary efficacy measures included criteria for subjective assessment by International Knee Documentation Committee (IKDC) and pain severity by Visual Analog Scale (VAS) for 52 weeks...
February 27, 2018: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/29472734/a-meta-analysis-of-the-association-of-ckm-gene-rs8111989-polymorphism-with-sport-performance
#8
Chunyang Chen, Yan Sun, Hao Liang, Dan Yu, Songnian Hu
The muscle-specific creatine kinase (CKM) A/G variants (rs8111989) have been associated with skeletal muscle performance in humans; they are correlated with physical performance and contribute to differences in the maximum oxygen uptake (VO2 max) responses during power or endurance training. However, there is not enough definitive evidence to demonstrate whether the A and G allelic variants of the CKM gene rs8111989 are indeed genetic factors that can influence human physical performance. In our study, we identified 9 articles on CKM in a literature search, and conducted two meta-analyses on the CKM rs8111989 A/G allele or genotype differences between power or endurance athletes and general controls...
December 2017: Biology of Sport
https://www.readbyqxmd.com/read/29471354/a-coliform-targeted-metagenomic-method-facilitating-human-exposure-estimates-to-escherichia-coli-borne-antibiotic-resistance-genes
#9
A F C Leonard, X L Yin, T Zhang, M Hui, W H Gaze
Background: Antimicrobial resistance and the spread of antibiotic resistance genes (ARGs) poses a threat to human health. Community-acquired infections resistant to treatment with first-line antibiotics are increasing, and there are few studies investigating environmental exposures and transmission. Aim: To develop a novel targeted metagenomic method to quantify the abundance and diversity of ARGs in a faecal indicator bacterium, and to estimate human exposure to resistant bacteria in a natural environment...
February 19, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29470824/turning-up-the-heat-an-evaluation-of-the-evidence-for-heating-to-promote-exercise-recovery-muscle-rehabilitation-and-adaptation
#10
REVIEW
Hamish McGorm, Llion A Roberts, Jeff S Coombes, Jonathan M Peake
Historically, heat has been used in various clinical and sports rehabilitation settings to treat soft tissue injuries. More recently, interest has emerged in using heat to pre-condition muscle against injury. The aim of this narrative review was to collate information on different types of heat therapy, explain the physiological rationale for heat therapy, and to summarise and evaluate the effects of heat therapy before, during and after muscle injury, immobilisation and strength training. Studies on skeletal muscle cells demonstrate that heat attenuates cellular damage and protein degradation (following in vitro challenges/insults to the cells)...
February 22, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29468337/psychosocial-impact-of-a-positive-gene-result-for-asymptomatic-relatives-at-risk-of-hypertrophic-cardiomyopathy
#11
Carissa Bonner, Catherine Spinks, Christopher Semsarian, Alex Barratt, Jodie Ingles, Kirsten McCaffery
Families with a history of hypertrophic cardiomyopathy (HCM) may be offered genetic testing in addition to clinical surveillance. Asymptomatic family members who are gene positive (silent gene carriers) represent a new group of "patients" who may not develop HCM, with little evidence available to assist clinical management. This study explored experiences of HCM genetic testing to identify potential benefits and harms. Thirty-two individuals previously offered genetic testing for HCM were recruited...
February 22, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29466506/first-molecular-data-for-lernaea-cyprinacea-copepoda-cyclopoida-infesting-odontesthes-bonariensis-a-commercially-important-freshwater-fish-in-argentina
#12
Iris Aparecida Soares, Víctor Salinas, Omar Del Ponti, Miguel Alberto Mancini, José Luis Luque
Parasitic copepods of the family Lernaeidae are often found infesting freshwater fishes worldwide. They cause lernaeosis, a disease that can lead to serious pathogenic effects on their fish hosts. The most common lernaeid is the Lernaea cyprinacea, which has been widely introduced through importation of tropical fishes, e.g. cyprinids. In South America, it is one of the most common parasites both in wild and in farmed fish in the central region of Argentina. The silverside Odontesthes bonariensis is the most important fish of the sport fisheries of Argentina and one of the fish most affected by lernaeosis...
February 19, 2018: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/29466246/modified-aging-of-elite-athletes-revealed-by-analysis-of-epigenetic-age-markers
#13
Magdalena Spólnicka, Ewelina Pośpiech, Jakub Grzegorz Adamczyk, Ana Freire-Aradas, Beata Pepłońska, Renata Zbieć-Piekarska, Żanetta Makowska, Anna Pięta, Maria Victoria Lareu, Christopher Phillips, Rafał Płoski, Cezary Żekanowski, Wojciech Branicki
Recent progress in epigenomics has led to the development of prediction systems that enable accurate age estimation from DNA methylation data. Our objective was to track responses to intense physical exercise of individual age-correlated DNA methylation markers and to infer their potential impact on the aging processes. The study showed accelerated DNA hypermethylation for two CpG sites in TRIM59 and KLF14 . Both markers predicted the investigated elite athletes to be several years older than controls and this effect was more substantial in subjects involved in power sports...
February 15, 2018: Aging
https://www.readbyqxmd.com/read/29453741/fuel-for-the-work-required-a-theoretical-framework-for-carbohydrate-periodization-and-the-glycogen-threshold-hypothesis
#14
Samuel G Impey, Mark A Hearris, Kelly M Hammond, Jonathan D Bartlett, Julien Louis, Graeme L Close, James P Morton
Deliberately training with reduced carbohydrate (CHO) availability to enhance endurance-training-induced metabolic adaptations of skeletal muscle (i.e. the 'train low, compete high' paradigm) is a hot topic within sport nutrition. Train-low studies involve periodically training (e.g., 30-50% of training sessions) with reduced CHO availability, where train-low models include twice per day training, fasted training, post-exercise CHO restriction and 'sleep low, train low'. When compared with high CHO availability, data suggest that augmented cell signalling (73% of 11 studies), gene expression (75% of 12 studies) and training-induced increases in oxidative enzyme activity/protein content (78% of 9 studies) associated with 'train low' are especially apparent when training sessions are commenced within a specific range of muscle glycogen concentrations...
February 16, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29401200/actn3-genotype-in-professional-sport-climbers
#15
Michał Ginszt, Małgorzata Michalak-Wojnowska, Piotr Gawda, Magdalena Wojcierowska-Litwin, Iwona Korszeń-Pilecka, Małgorzata Kusztelak, Rafał Muda, Agata A Filip, Piotr Majcher
The functional RR genotype of the alpha-actinin-3 (ACTN3) gene has been reported to be associated with elite sprint/power athlete status. Although large and rapidly increasing number of studies have investigated the associations between the ACTN3 genotypes and athletic performance in various sport disciplines, there is a lack of studies on the genetic predisposition in Sport Climbing, which was selected to be part of the next Summer Olympic Games in Tokyo 2020 with three subdisciplines ('Lead Climbing', 'Speed Climbing' and 'Bouldering')...
February 1, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29345072/genetic-monitoring-of-horses-in-the-czech-republic-a-large-scale-study-with-a-focus-on-the-czech-autochthonous-breeds
#16
L Putnová, R Štohl, I Vrtková
We propose the first comprehensive in-depth study monitoring horses in the Czech Republic. We scanned 9,289 animals from 44 populations for 17 equine STRs. Other equids analysed involved Equus przewalskii and Equus asinus. The total of 228 different alleles were detected, with the mean number of 13.4 per locus. The highest allelic richness (AR) was found in the Welsh Part Bred (6.01), followed by the Camargue (5.93) and Czech Sport Pony (5.91), whereas the Friesian exhibited the lowest AR (3.06). Interpopulation differences explained approximately nine per cent of the total genetic diversity...
February 2018: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
https://www.readbyqxmd.com/read/29291385/serological-detection-and-molecular-characterization-of-piroplasmids-in-equids-in-brazil
#17
Maria Isabel Botelho Vieira, Márcio Machado Costa, Mateus Tonial de Oliveira, Luiz Ricardo Gonçalves, Marcos Rogério André, Rosangela Zacarias Machado
Equine piroplasmosis is a disease caused by the hemoparasites Babesia caballi and Theileria equi and is considered to be the most important parasitic infection affecting Equidae. The objective of the present study was to carry out an epidemiological molecular and serological survey for the presence of these two protozoal organisms in equids from the northwestern region of the State of Rio Grande do Sul (RS), south Brazil. For this purpose, blood samples were collected from 90 equids in the city of Passo Fundo, RS, Brazil...
March 2018: Acta Tropica
https://www.readbyqxmd.com/read/29262476/-short-stature-optic-nerve-atrophy-and-pelger-hu%C3%A3-t-anomaly-syndrome-with-antibody-immunodeficiency-and-aplastic-anemia-a-case-report-and-literature-review
#18
REVIEW
T Y He, N Zhang, Y Xia, Y Luo, C R Li, J Yang
Objective: To investigate the clinical features and genetic characteristics of cases with NBAS gene defects. Method: Characteristics of clinical materials, immunological data and gene mutation of the first case in China with NBAS gene mutation were retrospectively analyzed. The related literature was searched by using search terms'NBAS'. Result: A 2-year-four-month old girl, was admitted due to 'fever and pallor for one day'. There was an intrauterine growth retardation at her fetal stage. Since her birth, she had suffered from recurrent infections and development delay was accompanied by persistent liver dysfunction...
December 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29186495/sugar-metabolism-reprogramming-in-a-non-climacteric-bud-mutant-of-a-climacteric-plum-fruit-during-development-on-the-tree
#19
Macarena Farcuh, Bosheng Li, Rosa M Rivero, Lyudmila Shlizerman, Avi Sadka, Eduardo Blumwald
We investigated sugar metabolism in leaves and fruits of two Japanese plum (Prunus salicina Lindl.) cultivars, the climacteric Santa Rosa and its bud sport mutant the non-climacteric Sweet Miriam, during development on the tree. We previously characterized differences between the two cultivars. Here, we identified key sugar metabolic pathways. Pearson coefficient correlations of metabolomics and transcriptomic data and weighted gene co-expression network analysis (WGCNA) of RNA sequencing (RNA-Seq) data allowed the identification of 11 key sugar metabolism-associated genes: sucrose synthase, sucrose phosphate synthase, cytosolic invertase, vacuolar invertase, invertase inhibitor, α-galactosidase, β-galactosidase, galactokinase, trehalase, galactinol synthase, and raffinose synthase...
December 16, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29172065/dna-methylation-markers-in-combination-with-skeletal-and-dental-ages-to-improve-age-estimation-in-children
#20
Lei Shi, Fan Jiang, Fengxiu Ouyang, Jun Zhang, Zhimin Wang, Xiaoming Shen
Age estimation is critical in forensic science, in competitive sports and games and in other age-related fields, but the current methods are suboptimal. The combination of age-associated DNA methylation markers with skeletal age (SA) and dental age (DA) may improve the accuracy and precision of age estimation, but no study has examined this topic. In the current study, we measured SA (GP, TW3-RUS, and TW3-Carpal methods) and DA (Demirjian and Willems methods) by X-ray examination in 124 Chinese children (78 boys and 46 girls) aged 6-15 years...
March 2018: Forensic Science International. Genetics
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